ELDA: Extreme Limiting Dilution Analysis
Fit single-hit model to a dilution series using complementary log-log binomial regression.
Compare Groups of Growth Curves
Compare Groups of Growth Curves performs a permutation test of the difference between two groups of growth curves. It calculates all pairwise comparisons between two or more groups of growth curves.
Gene Mapping and Linkage
*updated July 2011*
Performs QC and generates output formats from many common Affymetrix and Illumina SNP chips, as well as NGS/MPS data. Output formats include MERLIN, ALLEGRO, PLINK, MORGAN, FEstim and PREST. Different HAPMAP populations can be chosen as the source of marker allele frequencies.
XIBD *updated Oct 2015*
XIBD (X chromosome Identity by Descent) detects identity by descent using dense SNP chip data on the X chromosome.
Gene Prioritisation for candidate genes from linkage, association or NGS studies, specifically for brain disorders using the Allen Humna Brain Atlas data.
Age of mutation estimation
R script which performs the calculations required to produce mutation age estimates and confidence intervals using the method described in Gandolfo, L. C., Bahlo, M., and Speed, T. P. (2014). Dating rare mutations from small samples with dense marker data. Genetics, 197(4): 1315-27.
Creating Mapmaker or R/qtl input files
Converts genotyping and phenotyping data into mapmaker style input files for use with MAPMAKER or R/QTL.
Performs genome linkage disequilibrium (LD) mapping with case and control haplotype data with both microsatellite and SNP markers.
Genotype-Based Identification of Relative Pairs - identifies pairs of individuals who may be related to each other by comparing their genotypes.
A script that calculates two measures of the efficiency of a genome- wide mutation screen for recessive phenotypes and performs simulations to confirm results
EffiSim Web Interface
This is a web interface to the EffiSim script above.
Quantitative Trait Haplotype Analysis
A program to test whether a quantitative trait loci is in the vicinity of a number of markers that are fully linked with each other.
An R Library for Linear Models for Microarray Data. Uses linear models for analysing designed microarray experiments and for assessing differential expression.
MSigDB Gene Sets
R versions of the MSigDB gene sets.
Gender Gene Sets
R version of the Gender gene sets.
An R Library for Statistical Modelling and biostatistical analysis including comparison of growth curves and the analysis of randomized block designs.
An R Library for preprocessing Illumina Whole Genome Expression BeadChips.
Finding Isoforms with Robust Multichip Analysis. R code for analysing Affymetrix exon arrays. Estimates gene expression and calculates scores for alternative splicing detection.
An R package (empirical analysis of digital gene expression in R) for differential expression (DE) analysis of count data e.g. digital gene expression such as RNA-seq or SAGE data.
An R library for performing Gene Ontology (GO) and other category based tests on RNA-seq data, which corrects for selection bias.
Subread and Subjunc (R version
Subread is a general-purpose read aligner (mapping both gDNA- and RNA-seq reads). It is espeically powerful in mapping RNA-seq reads for the purpose of expression analysis. Subjunc is designed to discover exon-exon junctions from using RNA-seq data. It performs full alignments for RNA-seq reads.
Get A Bit Of Sequence/Get A Few Exon Primers.
GABOS retrieves sequence for Exons, Introns, 5'UTRs, CDS, 3'UTRs, Transcripts, Genomic Sequence and DNA between any two co-ordinates. Sequence can be specified by a list of gene names, or by selecting all genes within a chromosomal co-ordinate range. Additional up or down stream sequence maybe specified or sequence maybe limited by base number range within an object (For eg. first 50 bases of each exon). 10 genomes are available, others can be requested. Gene definitions are taken from UCSC defined sets like refGene, Ensembl genes, MGC genes, Repeat Sequences, EST's, mRNA, STS's etc.
GAFEP will retrieve primers created by Primer3 around exons and introns selected by GABOS. Large exons/introns will be split to optimum size blocks and small ones will be padded out with adjacent sequence.
Mungo python library
A python library supporting parsing, manipulation and visualisation of sequence analysis results (available via our Github repository).
Prediction of genomic rearrangements from next generation sequencing of somatic and germline DNA.