Bioinformatics Seminar
Time: 11AM
Venue: Davis Auditorium and Online
13 October 2026
This is a WEHI only event.Spatial Transcriptomics in Blood Cancers: Locally Restricted Niche Dynamics in Multiple Myeloma and TP53-Mutant AML
Ruqian LyuWEHI
Treatment resistance in blood cancers is often shaped by highly local biology within the bone marrow niche - signal that is lost when tissue is dissociated for bulk or single-cell analysis. I will present two studies using spatial transcriptomics to characterize treatment response and resistance in blood cancers. In the first part of the talk, I will show how we used a mouse model of multiple myeloma, combined with intravital imaging and Xenium spatial transcriptomics to characterize the response and relapse after bispecific antibody treatment. I will then show our most recent work extending the spatial methods to a human TP53-mutant Acute Myeloid Leukemia study, pairing Xenium with same-section p53 protein staining across 42 bone marrow trephines.