Bioinformatics Seminar
Time: 11AM
Venue: Davis Auditorium and Online
6 October 2026
This is a WEHI only event.Decoding the complex genomes of cancer brain metastases
Peinan ZhaoWEHI
Brain metastases are lethal complication of advanced cancer, yet the mechanisms driving their evolution remain poorly understood. In this seminar, I will present a multiomic study of pan-cancer brain metastases, with a focus on the genomic layer. First, I will outline the genomic landscape of brain metastases and discuss analytical strategies tailored to high-coverage WGS with matched germline, and to tumour-only low-pass WGS. Second, I will examine complex genomic rearrangements in brain metastases and introduce a suite of complementary tools used to decipher them. Lastly, I will show how we decomposed tumour methylation data into latent components, and explore the link between methylation patterns and genomic instability.