Bioinformatics Seminar
Time: 11AM
Venue: Davis Auditorium and Online
9 September 2025
This is a WEHI only event.Spatio-temporal characterisation of glioma
Joel MoffetWEHI Bioinformatics/Personalised Oncology
Gliomas are cancers of the brain with a five-year survival rate of 22%, with current standard of care unable to prevent disease progression. The leading edge of the tumor is a key architecture involved in both recurrence and progression, but spatially resolved characterisation of this region is lacking. Increasing the dimensionality at which we interrogate glioma – into space and time, and across omics platforms – will improve our understanding of the underlying mechanisms causing biological dysfunction. In his PhD, Joel has developed a spatial multi-omic integration pipeline, SMINT, to integrate transcriptomics and metabolomics at the leading edge across serial sections of IDH-mutant glioma. By interpolating between sections via Kriging, this pipeline can be extended to develop a 3D model of disease architecture. Investigating glioma by combining the SMINT pipeline with Kriging interpolation will improve our ability to identify spatial drivers of tumorigenesis and develop effective treatments for patients.