Bioinformatics Seminar
Time: 11AM
Venue: Davis Auditorium and Online
10 October 2023
Quantitative cell biology of gene expression
Scott BerryUNSW
Transcription rates are coordinated with cell size to maintain constant concentrations of mRNA in differently sized cells. I will describe how we are using quantitative measurement of mRNA and protein abundance at the single-cell level together with perturbation studies and mathematical modelling to understand the mechanistic basis of this phenomenon. I will also describe recently developed experimental and computational approaches we use to visualise and quantify many different proteins within the same single cells, at high resolution. These versatile approaches have the potential to be widely applied in perturbation screening studies and will enable systematic mapping of multiscale atlases of biological organisation.