Bioinformatics Seminars

Bioinformatics Seminar

Time: 11AM
Venue: Hybrid

30 May 2023

Computational analysis of nanoparticle cell interactions.

Sam Lee
WEHI Bioinformatics

Understanding the behaviour of nanoparticles in human blood requires a careful understanding of factors that may influence interactions with different cell-types. These include, but are not limited to, the formation of protein coronas around particles. While experimental methods exist to test nanoparticle cell interactions, they are constrained in throughput due to experimental complexity and cost. We present progress towards a linear modelling approach for the proteomics-based analysis of nanoparticle cell interactions using a ligand-receptor interaction framework. Importantly, our model can integrate cell-type specific receptor profiles to improve specificity. We test our model on experimental data from association experiments and find the inclusion of ligand-receptor information to be beneficial. Overall, our approach provides a new research direction for the screening of nanoparticle cell interactions.

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