Bioinformatics Seminar
Time: 11AM
Venue: Davis Auditorium and Teams
9 August 2022
Identification of novel oncogenic and neurodevelopmental programs using bulk and single-cell sequencing approaches
Jeremy SimonUniversity of North Carolina
Establishing and maintaining proper transcriptional programs is central to both development and disease, and involves the careful orchestration of transcription factors and chromatin modifier proteins. My groups seek to untangle these complex systems, ask biologically-driven questions, and formulate new hypotheses using analysis and integration of bulk or single-cell high-throughput sequencing approaches. I will focus on two vignettes highlighting recent collaborative projects: first, a longitudinal transcriptomics analysis of neocortical development in a mouse model of autism, and second, the identification of novel oncogenic drivers and mechanisms in renal cell carcinoma.