Bioinformatics Seminars

Bioinformatics Seminar

Time: 11AM
Venue: Zoom Webinar

20 July 2021

Computational Biology of TILs Prognosis and Drug Response Prediction in Colorectal Cancer

Jinjin Chen
WEHI Bioinformatics

Colorectal cancer (CRC) is a top cause of cancer-related morbidity and mortality with many CRC-related every year. It is currently difficult to predict the prognosis for CRC patients due to significant tumor heterogeneity.

Recent studies have suggested roles of Tumor-infiltrating inflammation as a strong prognostic indicator of CRC and may be able to guide precision therapy of cancer patients. There are many studies focusing on tumor-infiltrating lymphocytes (TILs) in CRC, but very limited on natural killer (NK) cells.

The initial focus of my PhD is aimed at developing a workflow for screening immune specific signature genes correlating immune cell infiltration with patient outcomes. This talk focuses on a formulating a CRC specific NK cell signature that can be used to explore the infiltration landscape in CRC. This insight could have implications for immunotherapy.

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