Current Bioinformatics Seminar
Time: 11AM Tuesdays.
Venue: Davis Auditorium and Online
4 February 2025
This is a WEHI only event.Deconvolution of the prostate tumour microenvironment
William HutchisonWEHI Bioinformatics
Prostate cancer is a common and severe disease, affecting approximately 24,000 men in Australia each year. However, predicting disease progression and ensuring long-term relapse-free survival remain major challenges. Growing evidence highlights the prognostic and therapeutic potential of non-tumour cells in the prostate tumour microenvironment. In this study, we aim to better characterise the relationship between non-tumour cells and the developing cancer. To achieve this aim, we constructed a large single-cell RNA sequence prostate cancer atlas from publicly available data. Using this atlas as a reference, we deconvolved cell type proportions from a bulk RNA sequence dataset with overlapping whole-genome sequence and methylation data. Our analysis reveals widespread tumour microenvironment alterations associated with common genomic events and clinical outcomes in prostate cancer. These findings provide new insights into tumour microenvironment dynamics, with potential implications for prognosis and therapy.