Bioinformatics Seminars

Current Bioinformatics Seminar

Time: 11AM Tuesdays.
Venue: Davis Auditorium and Teams

24 May 2022

Investigating Bacterial Microbiomes with Transfer RNA Arrays

Chris Woodruff
WEHI Bioinformatics

Transfer RNAs often occur in clusters in bacterial genomes. Here I outline an investigation of the feasibility of using this genomic feature to quantitatively characterise bacterial microbiomes using long read, whole genome shotgun sequencing. I describe the datasets used for the investigation so far, provide a simple theoretical analysis that supports the feasibility of the approach, describe the analysis method that leads to quantitative microbiome profiling, and present some early results. I conclude with some assessment of the limitations and potential value of this approach.


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