Current Bioinformatics Seminar
Time: 11AM Tuesdays.
Venue: Davis Auditorium and Online
14 April 2026
Advancing Spatial Transcriptomics: Comparative Analysis and Simulation Frameworks
Harry MuellerWEHI
Spatially resolved transcriptomics (ST) offers powerful insights into tissue structure and function, making the kidney - an anatomically well-defined organ - an ideal model. The signalling protein WNT4 is critical for nephron differentiation, yet its spatial effects are not well understood. In Aim 1, we perform a comparative analysis of wild-type and Wnt4-knockout embryonic kidney samples using Xenium in situ sequencing to investigate lineage-specific effects on spatial organization. In Aim 2, we aim to develop a flexible, biologically informed simulation framework for ST due to the rapid growth of ST methods.