Rank ID GeneSet NumGenes Type p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 mmu04966 Collecting duct acid secretion 19/27 Signaling 1.76953606831847e-08 3.21850522501729e-07 5 33.0909090909091 2 1.60866916595587e-09 1 1.90088900956574 -1.98653937976685 -1 35.001937781778 2 81 106 11 2 2 1 2 1 152 4 2 mmu00592 alpha-Linolenic acid metabolism 14/25 Metabolism 3.18703903702945e-08 3.21850522501729e-07 5 50.9090909090909 12 2.8973082574533e-09 2 2.14183771532191 -2.14183771532191 -1 39.5450318858904 4 89 93 60 12 3 2 4 188 102 3 3 mmu04721 Synaptic vesicle cycle 45/62 Signaling 3.93998778948292e-08 3.21850522501729e-07 5 42.7272727272727 18 3.58180714549481e-09 1 1.48651402871335 -1.48949890924209 -1 27.1888867571035 3 57 159 57 21 1 4 3 18 146 1 4 mmu05160 Hepatitis C 104/134 Disease 1.00842027059002e-07 3.39057270882892e-07 20 40.5454545454545 21 9.16745742557516e-09 6 1.90727584982404 -2.12683544718335 -1 34.9970738434047 20 11 86 6 77 21 59 36 21 93 16 5 mmu04270 Vascular smooth muscle contraction 88/129 Signaling 8.42092232449234e-08 3.28665356651842e-07 20 33.4545454545455 24 7.6553842243812e-09 2 2.7127958724284 3.14599864969943 1 50.2387708481569 43 17 9 32 66 24 125 5 26 19 2 6 mmu05323 Rheumatoid arthritis 59/83 Disease 4.52984367335906e-07 8.04680304708503e-07 25 71.1818181818182 24 4.11804055096648e-08 4 2.09074709879861 -2.26046692114786 -1 36.1652748128576 18 152 24 117 157 4 10 24 249 15 13 7 mmu04022 cGMP-PKG signaling pathway 121/168 Signaling 6.53182440153716e-08 3.21850522501729e-07 35 27.7272727272727 25 5.93802235951616e-09 5 2.43445219159308 2.65293455652737 1 45.0622854347465 33 6 14 34 46 8 50 20 64 25 5 8 mmu04360 Axon guidance 154/175 Signaling 3.48671853558225e-08 3.21850522501729e-07 15 38.5454545454545 25 3.16974417349298e-09 7 2.20811110869803 2.52306638054633 1 40.7946184390187 51 106 10 25 15 11 95 39 53 7 12 9 mmu04914 Progesterone-mediated oocyte maturation 75/87 Signaling 5.6077278603787e-08 3.21850522501729e-07 25 46.8181818181818 26 5.09793454847076e-09 5 1.64829283849411 1.7812662070657 1 30.2392304166751 24 26 117 62 38 5 21 18 51 133 20 10 mmu05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 50/72 Disease 1.33522784167602e-07 3.54027143235458e-07 25 36.6363636363636 26 1.21384356610355e-08 11 2.55958738920403 3.02218463727643 1 47.114095701557 25 47 11 26 100 25 54 23 41 29 22 11 mmu04921 Oxytocin signaling pathway 115/153 Signaling 3.12535128539411e-08 3.21850522501729e-07 10 31.0909090909091 30 2.84122848163027e-09 7 2.20225599647848 2.43889817420543 1 40.6842201460705 34 7 30 10 10 18 98 33 42 52 8 12 mmu04114 Oocyte meiosis 100/116 Signaling 5.5827517817165e-08 3.21850522501729e-07 30 59.8181818181818 36 5.0752290212593e-09 9 1.60594868905824 1.77135428676267 1 29.4408303794472 26 12 164 93 36 9 20 55 63 150 30 13 mmu04142 Lysosome 112/124 Signaling 1.96890317691931e-07 4.43390794172379e-07 10 88.8181818181818 37 1.78991213920682e-08 7 1.28988333429389 -1.33228515524046 -1 22.9602099550153 8 9 237 182 121 7 37 31 107 221 17 14 mmu04261 Adrenergic signaling in cardiomyocytes 105/147 Signaling 5.52998825680095e-08 3.21850522501729e-07 40 43.0909090909091 37 5.02726217800406e-09 10 2.27825464923628 2.51829165640467 1 42.1171767173909 72 10 19 37 35 52 83 34 39 37 56 15 mmu00591 Linoleic acid metabolism 12/50 Metabolism 2.4048707582127e-07 4.91280740606309e-07 15 55.2727272727273 39 2.18624638281337e-08 9 2.9976136243408 -2.47107363565744 -1 54.0816942852408 55 92 39 13 135 33 14 9 127 72 19 16 mmu05321 Inflammatory bowel disease (IBD) 38/59 Disease 1.1431751197149e-07 3.45621271416371e-07 40 68.5454545454545 40 1.03925016283377e-08 11 2.11727922741721 -2.11600680153666 -1 38.8916928768442 17 123 40 120 87 26 26 38 174 11 92 17 mmu00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 18/20 Metabolism 4.60059604534214e-07 8.12203993190032e-07 30 57.2727272727273 41 4.18236091582716e-08 6 2.38878448201819 2.65210713414322 1 41.4122723846934 22 84 59 72 158 29 28 6 12 119 41 18 mmu04024 cAMP signaling pathway 134/197 Signaling 4.50023167073337e-08 3.21850522501729e-07 45 59.5454545454545 42 4.09111978435301e-09 9 2.11405687809198 2.2577380200694 1 39.021223478493 96 108 18 31 27 44 192 42 78 10 9 19 mmu04710 Circadian rhythm 29/31 Signaling 3.83273165945573e-06 4.72483299398421e-06 25 99.5454545454545 47 3.48430757878942e-07 22 1.52849904889722 -1.69770935923376 -1 22.8013251387504 29 162 182 142 228 22 22 28 47 210 23 20 mmu04713 Circadian entrainment 66/98 Signaling 6.82397063523678e-08 3.21850522501729e-07 35 61.4545454545455 50 6.20360986082093e-09 7 2.23006154425904 2.61994928786068 1 41.2084944715418 69 33 33 43 50 51 154 95 128 13 7 21 mmu04620 Toll-like receptor signaling pathway 71/99 Signaling 2.45384998492072e-07 4.9773127353711e-07 35 65.3636363636364 52 2.23077296238168e-08 13 1.81393270172339 -1.98210798476985 -1 32.3649254155101 13 34 122 77 137 20 52 27 111 92 34 22 mmu04144 Endocytosis 254/286 Signaling 6.58798902884903e-08 3.21850522501729e-07 50 111 53 5.98908111466276e-09 13 1.44407972483154 -1.33382159057474 -1 26.3887868554562 32 145 228 252 47 13 47 53 132 234 38 23 mmu04725 Cholinergic synapse 79/113 Signaling 6.85941350647542e-08 3.21850522501729e-07 55 100.363636363636 53 6.23583065486012e-09 23 2.08984224489022 2.30860879605182 1 38.5646559406558 210 23 53 47 51 246 174 111 48 42 99 24 mmu03320 PPAR signaling pathway 53/85 Signaling 3.32963733765393e-08 3.21850522501729e-07 35 68.0909090909091 54 3.02694308004276e-09 13 2.15375026741423 -2.0049140159665 -1 39.7696433649424 87 45 48 126 13 54 34 117 125 32 68 25 mmu04916 Melanogenesis 75/100 Signaling 1.70203970133973e-07 4.0906164250686e-07 100 78.9090909090909 54 1.547308939108e-08 24 2.23376509750878 2.3356565370604 1 40.6027746049004 99 29 44 39 113 78 194 147 24 54 47 26 mmu00514 Other types of O-glycan biosynthesis 21/22 Metabolism 1.28308231317868e-06 1.83480770784552e-06 35 72.6363636363636 56 1.16643914681598e-07 22 2.00317123928263 2.20426528080119 1 32.5327395633283 35 79 87 71 197 32 30 22 56 145 45 27 mmu04727 GABAergic synapse 52/88 Signaling 2.16123345964601e-07 4.64746443202075e-07 60 95.0909090909091 56 1.96475788360095e-08 29 2.25684767889578 2.6275352028397 1 40.6677280297657 169 48 43 42 127 194 225 56 57 56 29 28 mmu04530 Tight junction 132/167 Signaling 1.52330732934584e-07 3.78839909732964e-07 110 53.2727272727273 57 1.38482494074685e-08 2 2.20861597583233 -2.34615370326924 -1 40.3499993516332 65 109 29 2 109 87 57 21 8 66 33 29 mmu04670 Leukocyte transendothelial migration 84/117 Signaling 1.34926428715611e-07 3.54027143235458e-07 20 103 57 1.22660397264251e-08 3 2.20758372986593 -2.45552304654922 -1 40.5193621778207 195 16 15 3 103 284 249 158 36 17 57 30 mmu04940 Type I diabetes mellitus 34/70 Disease 1.52435077005318e-06 2.10610782722323e-06 60 90.3636363636364 60 1.385774387506e-07 7 1.59577488293395 -1.60608865760844 -1 25.4681058477528 7 67 100 159 204 16 38 45 239 59 60 31 mmu04064 NF-kappa B signaling pathway 73/103 Signaling 9.70806589380357e-08 3.39057270882892e-07 30 61.6363636363636 61 8.82551483836088e-09 5 2.17905001028853 -2.36038362725827 -1 40.1035299906182 52 28 37 5 74 75 77 61 155 26 88 32 mmu05140 Leishmaniasis 48/66 Disease 1.35282198214684e-06 1.88735164338535e-06 205 104.454545454545 62 1.22983892183965e-07 23 1.87202431914576 -2.09821910634393 -1 30.2812124563701 23 189 115 191 202 30 45 51 202 39 62 33 mmu05414 Dilated cardiomyopathy 62/89 Disease 1.55352735984033e-07 3.79751132405415e-07 35 64.8181818181818 62 1.41229769958408e-08 13 2.47134766580077 2.85302149116963 1 45.2423005430686 31 117 13 101 111 62 100 50 73 34 21 34 mmu04260 Cardiac muscle contraction 51/78 Signaling 1.48361285032003e-07 3.74085715291867e-07 15 87 64 1.34873904579124e-08 12 2.33271433021989 2.4793959759801 1 42.7015160477034 12 231 85 150 107 41 16 26 58 167 64 35 mmu05217 Basal cell carcinoma 41/55 Disease 2.99982727989102e-06 3.79624160198598e-06 65 75.8181818181818 64 2.72711942757898e-07 22 2.473666519247 2.77612440569539 1 38.1025768177185 64 63 35 56 223 64 106 76 22 48 77 36 mmu00590 Arachidonic acid metabolism 34/89 Metabolism 6.68048380871875e-08 3.21850522501729e-07 115 64.1818181818182 65 6.07316728325204e-09 4 2.78899700492877 -2.57497689113741 -1 51.747237097193 113 65 16 4 48 125 46 87 68 22 112 37 mmu04662 B cell receptor signaling pathway 57/72 Signaling 9.37015328029311e-08 3.39057270882892e-07 40 72.4545454545455 65 8.51832152671181e-09 17 1.62649975575472 -1.74309481479501 -1 29.7214773367302 58 39 143 17 72 65 36 64 77 154 72 38 mmu04974 Protein digestion and absorption 56/90 Signaling 2.21813978897479e-14 6.34387979646789e-12 5 78.2727272727273 65 2.01649071724982e-15 1 3.10082995405124 2.99083384065784 1 100 16 36 1 65 235 79 182 116 66 2 63 39 mmu05231 Choline metabolism in cancer 85/99 Disease 5.89678413744632e-08 3.21850522501729e-07 20 87.8181818181818 65 5.36071299591013e-09 19 1.50199205827414 -1.45374424641833 -1 27.4807254064137 116 19 171 19 42 61 65 179 158 101 35 40 mmu04512 ECM-receptor interaction 75/83 Signaling 4.08571781965404e-08 3.21850522501729e-07 10 88.9090909090909 66 3.71428899593793e-09 5 2.72836732972294 2.85920377060777 1 50.6040629967244 6 113 5 66 212 59 120 154 177 8 58 41 mmu04723 Retrograde endocannabinoid signaling 58/102 Signaling 8.50392880847424e-08 3.28665356651842e-07 45 129.090909090909 68 7.73084467017003e-09 41 1.97142832561147 2.33453148522826 1 36.279858856002 237 41 68 50 68 202 278 232 60 41 143 42 mmu05030 Cocaine addiction 34/48 Disease 8.22846818808015e-08 3.28665356651842e-07 65 120.818181818182 68 7.48042590531123e-09 18 2.10459910690878 1.99959619299343 1 38.7872780491363 206 68 46 18 64 203 270 114 65 45 230 43 mmu00232 Caffeine metabolism 2/6 Metabolism 6.29349507182056e-08 3.21850522501729e-07 5 80.4 69 6.99277249761832e-09 3 2.56637905046995 -2.56637905046995 -1 47.5497697848144 76 102 271 NA 62 60 3 97 4 114 15 44 mmu04380 Osteoclast differentiation 93/130 Signaling 6.9588845988373e-08 3.21850522501729e-07 70 83.6363636363636 69 6.32625892632347e-09 15 1.68142342475207 -1.6042639293735 -1 30.8639084809211 68 15 92 88 53 53 69 136 234 31 81 45 mmu04740 Olfactory transduction 30/1119 Signaling 2.93528371064825e-08 3.21850522501729e-07 10 74.4545454545455 69 2.66843977255581e-09 7 2.51886122398524 2.36841028645699 1 46.6538199324779 105 69 32 7 8 117 240 109 16 23 93 46 mmu04622 RIG-I-like receptor signaling pathway 50/68 Signaling 1.30368107621534e-06 1.85498899401785e-06 35 87.0909090909091 70 1.18516531704938e-07 19 1.77380999299917 -2.04071012387135 -1 28.6871899867099 28 121 139 175 198 31 31 19 70 103 43 47 mmu04664 Fc epsilon RI signaling pathway 48/68 Signaling 3.14607237387184e-08 3.21850522501729e-07 55 70.2727272727273 70 2.86006583532882e-09 11 1.72381932329305 -1.84195198262236 -1 31.6632842488698 90 53 119 22 11 111 82 70 30 130 55 48 mmu04930 Type II diabetes mellitus 34/48 Disease 6.8727822801312e-08 3.21850522501729e-07 240 118 70 6.2479840862149e-09 20 2.15010175397246 -1.56361647125312 -1 39.7008505492514 238 70 60 20 52 272 263 138 43 110 32 49 mmu04020 Calcium signaling pathway 115/183 Signaling 6.03385554910611e-08 3.21850522501729e-07 125 72.9090909090909 72 5.48532337690396e-09 4 2.35791112060159 2.41222416102854 1 43.6191015535441 121 4 6 29 45 72 178 125 135 5 82 50 mmu04970 Salivary secretion 56/78 Signaling 1.29709431416561e-07 3.54027143235458e-07 100 76.3636363636364 72 1.17917671876435e-08 6 2.4706976924165 2.3896269330047 1 45.4487611296899 100 38 7 33 96 39 72 278 98 6 73 51 mmu00565 Ether lipid metabolism 32/44 Metabolism 2.36635656913605e-07 4.86890632210727e-07 110 80.1818181818182 73 2.1512334760594e-08 35 2.38749607415714 -2.56950785109987 -1 42.9303965164153 106 73 56 35 134 86 67 47 141 95 42 52 mmu00910 Nitrogen metabolism 10/17 Metabolism 9.76806138194963e-08 3.39057270882892e-07 15 66.5454545454545 74 8.88005619604934e-09 11 2.96620232033813 -3.48439620045716 -1 54.8935996042127 117 94 49 14 75 82 24 126 11 74 66 53 mmu00511 Other glycan degradation 17/18 Metabolism 3.94243259419497e-07 7.13591222367023e-07 10 75.9090909090909 75 3.58403027334992e-08 6 1.31550306306553 -1.31018102179634 -1 22.6433683513291 21 85 190 113 152 17 8 7 75 161 6 54 mmu04971 Gastric acid secretion 48/74 Signaling 9.98571272223878e-08 3.39057270882892e-07 20 105.818181818182 76 9.07792106862396e-09 17 2.48053551267817 2.35489128749026 1 45.7682425385003 182 46 17 41 76 166 235 227 17 18 139 55 mmu05031 Amphetamine addiction 51/68 Disease 1.77877336805041e-07 4.16991133821655e-07 120 88.8181818181818 77 1.6170668289729e-08 45 1.9604078230821 2.00740534245092 1 35.483814713197 119 50 58 45 116 103 204 83 74 77 48 56 mmu00983 Drug metabolism - other enzymes 23/51 Metabolism 7.78000669236212e-07 1.24306252179641e-06 80 87.2727272727273 78 7.07273585787193e-08 46 2.01153761220812 2.25134651722212 1 33.659970437248 85 78 64 105 176 69 119 46 62 76 80 57 mmu05416 Viral myocarditis 55/88 Disease 2.56076986623956e-06 3.31874594979982e-06 50 104.363636363636 78 2.32797531540497e-07 34 1.57284472688276 -1.50886234782529 -1 24.1879667405954 48 44 123 141 217 34 60 132 201 70 78 58 mmu04972 Pancreatic secretion 57/103 Signaling 2.32515612241819e-07 4.85397555482921e-07 135 99.0909090909091 79 2.11377851651041e-08 12 2.28849793097605 -2.29565251764825 -1 41.1243366300412 159 40 25 68 132 189 131 79 76 12 179 59 mmu04390 Hippo signaling pathway 128/154 Signaling 8.01073717414116e-08 3.28665356651842e-07 180 106.636363636364 81 7.2824886053015e-09 1 2.1328554045692 2.61258272188806 1 39.3193045371576 180 1 52 81 63 176 275 121 25 63 136 60 mmu04911 Insulin secretion 53/85 Signaling 1.05825905269992e-07 3.39057270882892e-07 35 123.636363636364 81 9.62053730550019e-09 33 2.34887841883028 2.36504679733407 1 43.29449310237 219 51 34 40 81 180 286 253 35 33 148 61 mmu04015 Rap1 signaling pathway 168/213 Signaling 5.04226357881055e-08 3.21850522501729e-07 70 88.9090909090909 82 4.58387608579646e-09 32 1.89320654356878 2.09199635033375 1 34.857084685903 66 104 50 82 32 42 90 241 119 38 114 62 mmu03440 Homologous recombination 40/41 Signaling 5.28655105461295e-06 6.24774215545167e-06 10 115.181818181818 83 4.8059670528366e-07 6 1.31463447792475 1.41034755392177 1 19.0303076817795 19 218 210 160 239 6 6 41 226 83 59 63 mmu05330 Allograft rejection 30/64 Disease 2.63340381038701e-06 3.37736990928558e-06 130 110 83 2.39400632961928e-07 9 1.4561197761386 -1.40611176592003 -1 22.2984630359904 9 127 129 162 219 28 63 72 238 80 83 64 mmu00052 Galactose metabolism 24/32 Metabolism 7.48446789327585e-08 3.21850522501729e-07 85 94.8181818181818 84 6.80406195263617e-09 13 2.15275807242826 -2.22960628372089 -1 39.750935502716 84 134 131 132 59 84 74 52 13 196 84 65 mmu04977 Vitamin digestion and absorption 15/24 Signaling 1.2403793480725e-08 3.21850522501729e-07 140 91.0909090909091 85 1.12761759551442e-09 1 1.5666458069668 -1.5532171633667 -1 28.6997735169755 60 139 149 157 1 85 68 29 69 137 108 66 mmu00564 Glycerophospholipid metabolism 77/94 Metabolism 2.0336635643342e-07 4.47405984153524e-07 15 79.3636363636364 88 1.84878522938597e-08 10 1.78265326666704 -1.73237089911429 -1 32.0320182826287 44 114 137 155 123 15 29 10 88 144 14 67 mmu04520 Adherens junction 66/72 Signaling 1.1580186362933e-07 3.45621271416371e-07 125 106.909090909091 88 1.05274427022561e-08 28 1.59486150895358 -1.15806430217385 -1 29.0884449318571 125 35 165 38 88 55 58 254 28 160 170 68 mmu04510 Focal adhesion 180/199 Signaling 2.19511811809485e-07 4.68510284906812e-07 85 108.363636363636 89 1.99556212465417e-08 36 2.01952844690335 2.31830880034927 1 36.282495344315 46 176 36 170 128 89 155 84 162 81 65 69 mmu05132 Salmonella infection 65/78 Disease 1.15975537754985e-07 3.45621271416371e-07 25 86.9090909090909 89 1.05432312607973e-08 10 1.76395351384727 -1.89457459773169 -1 32.2614821220251 10 153 146 110 89 12 23 25 184 168 36 70 mmu04340 Hedgehog signaling pathway 39/44 Signaling 3.35778733700439e-08 3.21850522501729e-07 80 106.818181818182 91 3.05253398932108e-09 14 1.82382526006662 2.34729314781263 1 33.548898783741 118 190 154 174 14 76 91 77 34 197 50 71 mmu04614 Renin-angiotensin system 13/35 Signaling 1.43433817122684e-07 3.69568213487276e-07 85 92.0909090909091 91 1.30394387703788e-08 11 1.73490223579021 -1.98363969489234 -1 31.5697398684163 81 91 109 123 105 49 11 65 195 117 67 72 mmu04621 NOD-like receptor signaling pathway 132/169 Signaling 1.22882097149847e-07 3.50999444101379e-07 40 105.727272727273 92 1.11711003648626e-08 40 1.82991150970068 -1.89860763989615 -1 33.4635556547862 40 146 138 224 92 40 56 108 207 58 54 73 mmu05222 Small cell lung cancer 80/83 Disease 1.84732556032975e-07 4.26076701817991e-07 95 94.7272727272727 92 1.67938701404408e-08 20 1.84485960217863 1.99472266034683 1 33.2927384749164 92 20 83 36 118 93 219 205 104 47 25 74 mmu04724 Glutamatergic synapse 78/114 Signaling 1.23120725603964e-07 3.50999444101379e-07 260 128.090909090909 93 1.11927938631171e-08 12 2.13704656451124 2.18083968879198 1 39.2210100889855 218 24 41 12 93 172 257 258 79 27 228 75 mmu00603 Glycosphingolipid biosynthesis - globo series 11/16 Metabolism 5.96377708472647e-08 3.21850522501729e-07 95 92.1818181818182 94 5.4216156785391e-09 44 2.11729470895957 -2.23317400606482 -1 39.0822728635831 139 95 94 106 44 123 71 49 114 88 91 76 mmu04110 Cell cycle 119/124 Signaling 7.667402926729e-07 1.23195350395758e-06 115 88.9090909090909 94 6.97036872632787e-08 5 1.57198009182758 1.70491107549045 1 26.1390354775419 5 111 187 156 175 10 13 44 94 112 71 77 mmu04726 Serotonergic synapse 68/132 Signaling 1.23954349140697e-07 3.50999444101379e-07 210 122.454545454545 94 1.1268577829513e-08 8 2.17320794156134 2.33394535582078 1 39.8988795714263 246 31 38 8 94 262 206 207 44 55 156 78 mmu00740 Riboflavin metabolism 8/8 Metabolism 3.88742636900927e-07 7.12694834318367e-07 115 85.8181818181818 95 3.8874270490532e-08 2 2.00080774574411 -2.40524876628897 -1 34.8797564214731 115 97 278 16 155 95 35 15 2 109 27 79 mmu00830 Retinol metabolism 20/89 Metabolism 1.88252370881041e-06 2.51589617158774e-06 80 130.272727272727 95 1.71138665424903e-07 12 2.74443067433917 3.24625962933558 1 43.7891024275489 77 267 76 239 210 67 51 12 205 134 95 80 mmu04668 TNF signaling pathway 99/107 Signaling 8.48438848151159e-08 3.28665356651842e-07 80 124.272727272727 96 7.71308073519587e-09 62 1.82895164655691 -2.03711151342132 -1 33.5972226489058 62 182 114 219 67 80 78 122 253 94 96 81 mmu05212 Pancreatic cancer 61/64 Disease 2.66019965651953e-08 3.21850522501729e-07 85 110.636363636364 97 2.41836335335106e-09 5 1.24044851370569 -1.30936155523497 -1 22.5493150816782 82 42 213 97 5 94 64 134 189 194 103 82 mmu05332 Graft-versus-host disease 30/65 Disease 2.8439764159523e-06 3.63114845965338e-06 15 121.181818181818 98 2.5854364476494e-07 14 1.47224951622372 -1.42216792464318 -1 22.4202292333012 14 160 127 163 221 36 84 94 247 98 89 83 mmu05410 Hypertrophic cardiomyopathy (HCM) 59/84 Disease 2.30662311380338e-07 4.85069272461592e-07 75 99.5454545454545 100 2.09693032331344e-08 22 2.4753199093765 3.00941627984289 1 44.5521646022967 74 118 22 100 131 129 189 119 82 57 74 84 mmu00561 Glycerolipid metabolism 49/59 Metabolism 7.24138045985435e-08 3.21850522501729e-07 60 120.909090909091 101 6.58307336200638e-09 45 1.93559486045383 -2.0935845414209 -1 35.6563175015322 185 58 101 84 57 220 213 74 45 138 155 85 mmu05214 Glioma 58/64 Disease 7.5696874538286e-08 3.21850522501729e-07 165 109.181818181818 101 6.88153428571266e-09 23 1.47428754606015 1.51476320694385 1 26.9583561091738 101 43 185 23 60 92 132 162 151 162 90 86 mmu00053 Ascorbate and aldarate metabolism 8/27 Metabolism 3.76476875832487e-06 4.66185531090563e-06 40 113.454545454545 102 3.76477513640779e-07 15 2.03558210954094 2.03558210954094 1 30.6786327681163 38 143 268 165 230 27 15 35 102 185 40 87 mmu05033 Nicotine addiction 9/40 Disease 1.15976271814529e-06 1.68371643344951e-06 35 123.727272727273 102 1.15976332341804e-07 32 2.39140723484392 2.04237066944463 1 39.2598144120813 73 170 286 107 196 50 32 225 85 35 102 88 mmu05134 Legionellosis 47/58 Disease 5.02842008159252e-07 8.56028656747298e-07 50 120.727272727273 103 4.57129202810133e-08 30 2.21386119425874 -2.54660386391622 -1 38.1715740053892 30 232 103 194 163 47 41 73 220 179 46 89 mmu05133 Pertussis 57/75 Disease 2.66103342858054e-07 5.32206685716108e-07 105 105.636363636364 104 2.41912159131703e-08 28 1.99399073121101 -2.1263580376887 -1 35.4924819522161 104 119 80 133 139 91 88 106 206 68 28 90 mmu05145 Toxoplasmosis 92/108 Disease 1.94480533944879e-07 4.43390794172379e-07 105 115.090909090909 104 1.76800501033643e-08 18 1.90445384353465 -1.79059153242194 -1 34.2996248882127 130 18 81 103 119 104 94 194 150 49 224 91 mmu05152 Tuberculosis 122/178 Disease 2.06240706422245e-07 4.50265969746276e-07 180 108.636363636364 105 1.87491568869494e-08 38 1.67986405625159 -1.75221506906903 -1 30.1231267062112 47 147 179 204 124 38 44 60 178 105 69 92 mmu04918 Thyroid hormone synthesis 48/73 Signaling 1.31809212766978e-07 3.54027143235458e-07 50 123.454545454545 106 1.19826564240092e-08 49 2.00703117614292 2.01322858791654 1 36.7620414391812 209 55 62 49 97 136 184 128 106 50 282 93 mmu00600 Sphingolipid metabolism 41/48 Metabolism 4.491622291713e-07 8.02877484643699e-07 125 101.090909090909 107 4.08329382613068e-08 33 1.91584361048659 -1.914230361875 -1 33.0750346581503 107 124 151 104 156 63 61 142 33 122 49 94 mmu04080 Neuroactive ligand-receptor interaction 81/285 Signaling 9.30858087587949e-13 8.87418043500512e-11 5 124.272727272727 107 8.46234625080311e-14 3 3.1496877316003 3.34741197996905 1 91.1081271195127 241 21 3 55 136 184 268 107 86 3 263 95 mmu05014 Amyotrophic lateral sclerosis (ALS) 39/52 Disease 6.68773459662983e-08 3.21850522501729e-07 110 124 107 6.07975890902627e-09 49 1.2975741616958 -1.47726690203175 -1 23.626420658 94 66 201 180 49 148 107 82 116 214 107 96 mmu04115 p53 signaling pathway 64/68 Signaling 9.38064543098155e-07 1.43404152725185e-06 110 123.818181818182 108 8.52786311893204e-08 55 2.09593651050361 2.64095343402385 1 34.7296606126673 108 230 107 183 183 57 55 123 61 180 75 97 mmu04062 Chemokine signaling pathway 124/192 Signaling 5.58455399997027e-08 3.21850522501729e-07 110 113.454545454545 109 5.07686740157316e-09 5 1.81583478045719 -1.87785895845432 -1 33.3982380832043 109 5 105 173 37 122 79 177 200 90 151 98 mmu04973 Carbohydrate digestion and absorption 24/43 Signaling 1.55001086189554e-07 3.79751132405415e-07 110 142.454545454545 110 1.40910088281966e-08 38 2.20783540393668 1.7110062655605 1 40.3287521906267 239 77 72 46 110 205 231 200 38 107 242 99 mmu04978 Mineral absorption 36/46 Signaling 4.7244270602861e-07 8.18900690449591e-07 135 113.363636363636 110 4.29493461349224e-08 37 2.3273153053724 -2.2837922620575 -1 40.300932501331 134 159 55 102 161 155 73 110 37 87 174 100 mmu00650 Butanoate metabolism 19/27 Metabolism 9.99128524988736e-07 1.48828519868114e-06 105 117.909090909091 111 9.08299071584158e-08 76 2.0756267546102 1.77139613582224 1 34.2877960134395 122 86 104 108 189 101 76 130 142 128 111 101 mmu04310 Wnt signaling pathway 116/146 Signaling 3.967167984488e-07 7.13591222367023e-07 115 105.909090909091 111 3.60651699988272e-08 40 1.91518883950104 2.33924601865577 1 33.3482210341722 98 112 111 171 154 90 168 40 49 111 61 102 mmu04150 mTOR signaling pathway 134/152 Signaling 2.97140396727913e-08 3.21850522501729e-07 115 119.818181818182 112 2.70127637037459e-09 2 1.55904203202503 -1.38647735561714 -1 28.5564041429898 172 2 200 184 9 112 111 98 83 222 125 103 mmu05146 Amoebiasis 75/106 Disease 5.90422530553519e-08 3.21850522501729e-07 30 114.181818181818 112 5.3674776945356e-09 23 2.27311676346174 2.14926386150357 1 42.0203017476888 160 30 23 30 43 204 243 263 112 24 124 104 mmu04976 Bile secretion 38/71 Signaling 2.82652482592083e-07 5.57507655319557e-07 10 94.8181818181818 113 2.56956835369844e-08 8 2.86883155616006 2.45653139661244 1 51.2646183094965 165 62 8 27 141 113 113 157 9 14 234 105 mmu00980 Metabolism of xenobiotics by cytochrome P450 36/65 Metabolism 1.76897869175095e-07 4.16991133821655e-07 20 152 115 1.60816257635566e-08 20 2.48380909532066 2.35690251273315 1 45.181594371836 275 64 20 28 115 278 283 282 52 20 255 106 mmu04660 T cell receptor signaling pathway 75/103 Signaling 3.64564936403491e-08 3.21850522501729e-07 180 118.545454545455 116 3.31422674949768e-09 18 1.42710544299956 -1.30660728010753 -1 26.0687363307174 103 27 176 52 18 116 112 199 191 178 132 107 mmu05206 MicroRNAs in cancer 132/280 Disease 7.1634997779608e-08 3.21850522501729e-07 245 161.181818181818 116 6.51227273746737e-09 55 1.97091971638063 2.02074072402415 1 36.3223685773661 244 110 89 116 55 225 264 244 97 75 254 108 mmu00330 Arginine and proline metabolism 41/50 Metabolism 4.22233305690285e-08 3.21850522501729e-07 60 107 120 3.83848467085423e-09 25 1.7017130940642 1.52509064561988 1 31.2464707226938 129 60 102 69 25 120 123 150 217 60 122 109 mmu04320 Dorso-ventral axis formation 23/26 Signaling 1.49111089312143e-07 3.74085715291867e-07 165 123.272727272727 120 1.35555544925964e-08 68 1.47123297954866 -1.43358461864803 -1 26.6216797134945 164 164 173 79 108 132 92 68 90 166 120 110 mmu04917 Prolactin signaling pathway 59/72 Signaling 5.71864032610916e-08 3.21850522501729e-07 110 129.727272727273 121 5.19876406796225e-09 39 1.87043114349516 -1.92769222181547 -1 34.4276539260716 110 154 121 64 39 130 102 141 230 218 118 111 mmu04960 Aldosterone-regulated sodium reabsorption 30/38 Signaling 3.70272380768537e-07 6.85695891410549e-07 130 100.545454545455 121 3.36611311897707e-08 11 1.81462766152596 -1.96612896114847 -1 31.6443927187346 128 129 91 75 150 121 126 14 183 78 11 112 mmu05320 Autoimmune thyroid disease 30/79 Disease 3.21340288520458e-06 4.03084747880925e-06 125 124.272727272727 121 2.92127961711954e-07 27 1.44448365111428 -1.2742224749683 -1 21.7913092901622 27 128 125 164 225 45 87 118 248 79 121 113 mmu00480 Glutathione metabolism 48/59 Metabolism 1.9894094429919e-07 4.44508672418504e-07 250 149.909090909091 122 1.80855420262696e-08 30 1.7713237023803 -1.61887658607952 -1 31.8376205870494 283 49 90 99 122 195 229 249 55 30 248 114 mmu01040 Biosynthesis of unsaturated fatty acids 26/28 Metabolism 1.01450700034079e-07 3.39057270882892e-07 80 120.272727272727 123 9.22279133748837e-09 76 1.48051171980854 -1.63068996600278 -1 26.978459007457 91 76 142 143 78 115 108 163 130 123 154 115 mmu04540 Gap junction 70/86 Signaling 2.35921572567021e-07 4.86890632210727e-07 80 120.454545454545 125 2.14474179878695e-08 52 1.80833632778453 2.09266896270657 1 32.3127082267641 78 186 130 125 133 106 181 75 144 115 52 116 mmu02010 ABC transporters 35/46 Signaling 3.20591108165913e-06 4.03084747880925e-06 200 155.363636363636 126 2.91446886675079e-07 67 2.49675351026732 -1.75993058646451 -1 38.2771904209531 196 126 67 118 224 271 214 113 103 99 178 117 mmu04744 Phototransduction 9/27 Signaling 3.93022264396275e-08 3.21850522501729e-07 285 154.818181818182 126 3.93022271347267e-09 6 2.42538242173154 2.24530493975346 1 44.8912746884787 245 96 284 21 26 275 236 103 6 126 285 118 mmu05200 Pathways in cancer 327/393 Disease 8.30196700573567e-08 3.28665356651842e-07 130 137.272727272727 126 7.54724301729133e-09 62 1.92414786683112 2.19472142408746 1 35.3896340735749 127 174 84 217 65 97 260 228 126 62 70 119 mmu00230 Purine metabolism 143/178 Metabolism 1.0734041123069e-07 3.39057270882892e-07 45 132.272727272727 127 9.75821967890425e-09 45 1.52768389775977 1.4460179148932 1 27.8647929314209 45 179 193 253 83 74 89 127 118 157 137 120 mmu00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 20/24 Metabolism 2.79649554648803e-08 3.21850522501729e-07 70 117.727272727273 127 2.54226871094114e-09 6 2.24300315653536 2.47660546933973 1 41.4525089070863 168 83 70 70 6 252 208 133 15 163 127 121 mmu04912 GnRH signaling pathway 73/89 Signaling 7.65239004549565e-08 3.21850522501729e-07 260 145 127 6.95671846515752e-09 32 1.69570637404259 -1.54121774619708 -1 31.1332138607008 259 32 144 53 61 239 121 195 80 127 284 122 mmu00730 Thiamine metabolism 11/15 Metabolism 1.87755077218244e-06 2.51589617158774e-06 140 121.727272727273 128 1.70686579504235e-07 20 1.88869128510417 2.45263371108276 1 29.8735222690907 138 141 113 109 209 128 80 67 20 188 146 123 mmu00380 Tryptophan metabolism 27/46 Metabolism 2.21259305262e-06 2.91613646566506e-06 130 150.454545454545 130 2.01145025261938e-07 50 2.00886890752434 1.06750248746808 1 31.4537301854613 205 74 82 90 214 168 130 248 50 129 265 124 mmu00604 Glycosphingolipid biosynthesis - ganglio series 11/15 Metabolism 5.03703985539005e-06 6.00247249433981e-06 115 126.818181818182 130 4.57913762549998e-07 11 1.84104738278371 -1.7137162324396 -1 27.0796265828146 114 168 135 130 243 164 109 11 209 61 51 125 mmu04720 Long-term potentiation 51/67 Signaling 1.09434871058228e-07 3.40199707854927e-07 150 146.272727272727 130 9.94862513653282e-09 80 1.37516219286674 1.60691416725766 1 24.9931769506224 150 122 203 80 86 151 252 115 92 228 130 126 mmu05142 Chagas disease (American trypanosomiasis) 81/101 Disease 2.24422632028266e-07 4.75443501926548e-07 150 121.454545454545 130 2.04020595383351e-08 67 1.72638836098727 -1.74137895067905 -1 30.8621675923617 67 150 150 135 130 81 75 131 194 106 117 127 mmu04145 Phagosome 123/184 Signaling 4.67374930124553e-07 8.15178011525554e-07 15 107.090909090909 132 4.24886390377441e-08 11 1.61493379435948 -1.57800293666743 -1 27.7173369026007 11 180 170 200 159 14 43 13 232 132 24 128 mmu04742 Taste transduction 23/88 Signaling 1.47599257630689e-07 3.74085715291867e-07 245 138.181818181818 132 1.34181152302917e-08 16 2.54850341861193 -2.33330057539427 -1 46.7292912529922 243 132 26 67 106 243 191 218 46 16 232 129 mmu00430 Taurine and hypotaurine metabolism 8/11 Metabolism 9.94008097838166e-08 3.39057270882892e-07 185 151.909090909091 133 9.94008142300512e-09 53 2.2951232150633 1.52271441917218 1 42.2844684913052 184 98 274 76 85 133 53 226 244 108 190 130 mmu04730 Long-term depression 48/61 Signaling 2.92503206876368e-08 3.21850522501729e-07 260 154 133 2.65912009786703e-09 7 1.90407268965489 2.06330608076781 1 35.0619661525344 260 61 133 63 7 256 211 211 91 131 270 131 mmu04666 Fc gamma R-mediated phagocytosis 77/87 Signaling 1.94269097537986e-08 3.21850522501729e-07 175 107.181818181818 134 1.76608272048602e-09 3 1.66376097522094 -1.8195637788514 -1 30.5308825363441 175 25 134 58 3 190 139 144 153 73 85 132 mmu05032 Morphine addiction 51/92 Disease 4.62431507647199e-08 3.21850522501729e-07 160 125.454545454545 134 4.20392288515756e-09 30 1.86632958754818 1.92862274419906 1 34.35031898218 156 52 79 151 30 141 254 238 105 40 134 133 mmu00562 Inositol phosphate metabolism 64/70 Metabolism 9.33602339093326e-07 1.43404152725185e-06 95 143.818181818182 135 8.48729759346762e-08 26 1.5915214484358 -1.70556503713729 -1 26.1694982987232 95 198 189 203 182 99 127 135 89 239 26 134 mmu03030 DNA replication 35/35 Signaling 9.66681247425234e-05 0.000104950223962222 5 125.363636363636 135 8.78839750970183e-06 1 1.29364684143768 1.3280180179767 1 14.1097926579486 1 204 186 145 261 35 9 78 225 100 135 135 mmu00100 Steroid biosynthesis 18/19 Metabolism 3.56915090469689e-08 3.21850522501729e-07 150 118.272727272727 136 3.24468269327338e-09 10 2.59904264277418 -3.23751468142294 -1 48.1656426659356 147 166 97 127 17 147 136 100 10 195 159 136 mmu04913 Ovarian steroidogenesis 26/58 Signaling 1.03808966661204e-07 3.39057270882892e-07 80 150.272727272727 136 9.43717923268394e-09 77 2.3268543331515 2.61712125368332 1 42.8806751459132 212 163 77 136 79 231 226 186 113 124 106 137 mmu05310 Asthma 10/25 Disease 2.05189695082849e-06 2.7295001299393e-06 140 130.272727272727 136 1.86536260417739e-07 46 2.42398777011375 -2.51527488489685 -1 38.3290909993899 136 192 78 139 211 154 135 63 179 46 100 138 mmu00531 Glycosaminoglycan degradation 16/21 Metabolism 3.67006800024409e-08 3.21850522501729e-07 160 113.090909090909 138 3.33642551042604e-09 7 1.59132380353913 1.99794719321043 1 29.1650777831977 158 87 155 48 20 138 142 223 7 97 169 139 mmu05230 Central carbon metabolism in cancer 56/64 Disease 1.16012734461439e-07 3.45621271416371e-07 140 143.909090909091 138 1.05466127799224e-08 79 1.370063175924 1.4418025958892 1 24.87007002147 140 155 192 138 90 105 116 220 122 226 79 140 mmu00440 Phosphonate and phosphinate metabolism 6/6 Metabolism 4.89932839671681e-07 8.39046659557489e-07 175 137.727272727273 139 4.89932947687098e-08 23 1.32671019506442 -1.01734234235484 -1 22.5724157207779 171 101 275 134 165 100 27 139 23 198 182 141 mmu04672 Intestinal immune network for IgA production 22/43 Signaling 6.30838426641742e-07 1.03097022868308e-06 200 128.363636363636 139 5.73489643210376e-08 36 2.31196870052518 -2.64793952126324 -1 39.3581079173454 200 133 47 59 170 187 143 183 139 36 115 142 mmu00410 beta-Alanine metabolism 29/33 Metabolism 3.24958109267656e-07 6.19586795003665e-07 275 155.545454545455 140 2.95416506606049e-08 69 2.06502386587284 1.81940172602966 1 36.3908056099323 274 131 69 91 146 230 221 140 101 89 219 143 mmu00240 Pyrimidine metabolism 92/104 Metabolism 2.92555115102632e-07 5.69487419046174e-07 100 142.181818181818 142 2.65959230915e-08 50 1.35358112753635 1.4269570335997 1 23.7081989367194 50 183 208 201 142 110 115 99 99 190 167 144 mmu05218 Melanoma 52/69 Disease 1.1785230913848e-07 3.47482066119643e-07 140 145.454545454545 143 1.0713846859249e-08 56 1.7211761024042 2.055700831727 1 31.4471010314982 143 56 140 147 91 135 188 210 159 191 140 145 mmu00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/8 Metabolism 2.02499483943775e-07 4.47405984153524e-07 145 135.454545454545 144 2.02499502396496e-08 3 3.54840434135087 -4.97202540876362 -1 64.5917409622688 166 144 273 96 129 171 172 32 3 141 163 146 mmu05164 Influenza A 128/168 Disease 2.99148856813432e-07 5.77866466109317e-07 145 129 144 2.71953543173391e-08 39 1.78615484804585 -2.09330569207625 -1 31.5201393431816 59 194 157 186 144 108 150 88 152 142 39 147 mmu05340 Primary immunodeficiency 17/36 Disease 3.01056305770239e-07 5.77866466109317e-07 155 148.181818181818 145 2.73687588152662e-08 17 1.84139601211914 -1.80286460465077 -1 32.5209356515029 153 136 96 121 145 212 255 17 261 82 152 148 mmu00140 Steroid hormone biosynthesis 15/87 Metabolism 1.95823900912416e-07 4.43390794172379e-07 265 167.909090909091 146 1.78021743948067e-08 66 2.31632582933214 -1.52621714069591 -1 41.8990577866242 264 138 66 146 120 260 210 104 204 84 251 149 mmu04070 Phosphatidylinositol signaling system 85/96 Signaling 5.43108836187177e-07 9.13700747938428e-07 210 140.363636363636 146 4.93735427512025e-08 18 1.42573714456237 -1.3730682978115 -1 24.1666178690993 112 184 207 205 166 119 146 71 108 208 18 150 mmu00350 Tyrosine metabolism 21/39 Metabolism 5.5861637841822e-07 9.28862117602389e-07 215 137.272727272727 147 5.07833200236552e-08 40 2.59433910325933 1.7513896280536 1 44.6088669058972 215 80 54 89 168 165 147 231 40 104 217 151 mmu00770 Pantothenate and CoA biosynthesis 15/18 Metabolism 3.45731147612466e-07 6.54828531239506e-07 180 125 147 3.14301092676644e-08 5 2.54407836881506 2.6314452963677 1 44.8501358937774 178 90 88 44 147 160 180 185 5 136 162 152 mmu04722 Neurotrophin signaling pathway 113/121 Signaling 7.04464929895452e-08 3.21850522501729e-07 190 125.909090909091 147 6.40422684048378e-09 8 1.66704108063851 -1.38402836528632 -1 30.5927290091717 187 8 147 61 54 174 124 203 59 200 168 153 mmu00780 Biotin metabolism 3/3 Metabolism 0.000228175903265983 0.000242595941762346 75 158.545454545455 148 2.28199335561562e-05 18 0.812188187136492 -0.812188187136492 -1 7.68778698407229 75 213 280 148 268 73 18 59 257 206 147 154 mmu04640 Hematopoietic cell lineage 49/95 Signaling 1.65260531607373e-07 4.00546712200921e-07 195 132.454545454545 148 1.5023685820135e-08 9 2.66209514986552 -3.28572103614066 -1 48.6200397704681 194 157 21 83 112 237 177 148 110 9 209 155 mmu04650 Natural killer cell mediated cytotoxicity 63/118 Signaling 4.5640147732091e-08 3.21850522501729e-07 195 122.909090909091 148 4.14910442535634e-09 28 1.53617976800848 -1.39768575991633 -1 28.1253355612587 192 37 163 51 28 191 149 86 148 118 189 156 mmu05034 Alcoholism 101/199 Disease 2.6412375666301e-07 5.31967566236766e-07 150 150.818181818182 148 2.40112534884294e-08 105 1.62485135893 1.76003474022661 1 28.7674346445156 144 148 148 187 138 109 175 124 182 199 105 157 mmu04611 Platelet activation 99/124 Signaling 1.33011482166972e-07 3.54027143235458e-07 220 162.272727272727 149 1.20919536553468e-08 57 2.09178102253186 2.12135026501164 1 38.349816561075 220 149 57 122 99 183 285 259 117 65 229 158 mmu04151 PI3K-Akt signaling pathway 267/346 Signaling 1.39682341812995e-07 3.63174088713786e-07 100 150.727272727273 150 1.26983955165184e-08 45 2.1303709874072 2.41294770260355 1 39.0042520123901 133 214 45 169 104 96 218 260 173 96 150 159 mmu00120 Primary bile acid biosynthesis 11/16 Metabolism 3.76534467419301e-06 4.66185531090563e-06 175 165.181818181818 151 3.42304647152029e-07 99 1.85087422860854 2.39333834862453 1 27.8187018482954 174 140 118 124 227 134 99 247 243 151 160 160 mmu04012 ErbB signaling pathway 80/85 Signaling 9.36224889840156e-08 3.39057270882892e-07 115 145.363636363636 152 8.51113572438037e-09 71 1.53506264724702 -1.47252009290386 -1 28.0034347383297 154 115 178 114 71 159 152 236 115 186 119 161 mmu04920 Adipocytokine signaling pathway 57/71 Signaling 6.37514178182819e-07 1.03596053954708e-06 105 145.090909090909 152 5.79558511746568e-08 80 1.82844336546231 -1.56848399214986 -1 30.9400672221138 102 217 152 195 171 83 105 80 193 172 126 162 mmu05168 Herpes simplex infection 164/215 Disease 3.63673471866371e-07 6.79807927802497e-07 55 152.090909090909 152 3.30612301803488e-08 54 1.53086677944794 -1.66639018853754 -1 26.5814223542801 54 240 217 225 149 88 93 152 196 183 76 163 mmu00512 Mucin type O-Glycan biosynthesis 20/28 Metabolism 3.9636629096485e-07 7.13591222367023e-07 195 148.181818181818 153 3.60333056706177e-08 63 2.41437969287689 3.07273015653518 1 42.2591619902411 253 82 63 87 153 244 195 193 96 91 173 164 mmu00072 Synthesis and degradation of ketone bodies 9/11 Metabolism 2.58485751430743e-06 3.33004166257624e-06 100 164.272727272727 154 2.58486052098212e-07 96 2.24732249223603 1.73616263513507 1 34.9107267271659 177 99 269 111 220 145 96 188 154 125 223 165 mmu00061 Fatty acid biosynthesis 12/14 Metabolism 0.000110910363605695 0.000119699486759353 45 133.909090909091 156 1.00832686739487e-05 12 1.54357760693727 -1.59994356933621 -1 16.7419402076636 42 222 156 197 286 37 12 48 214 165 94 166 mmu04750 Inflammatory mediator regulation of TRP channels 77/125 Signaling 8.73760229832768e-08 3.33193900976229e-07 25 140.272727272727 157 7.9432751321396e-09 15 2.16992171436772 2.4603800648998 1 39.9797584659361 252 22 27 15 69 217 277 245 157 21 241 167 mmu00030 Pentose phosphate pathway 27/32 Metabolism 0.000327561549175015 0.000343159718183349 100 175.363636363636 160 2.97827573192001e-05 97 1.28026275427634 -1.41977712733324 -1 12.0421022673778 97 221 214 178 267 153 138 101 160 251 149 168 mmu00471 D-Glutamine and D-glutamate metabolism 3/3 Metabolism 8.455578112083e-05 9.23013488570893e-05 125 157.818181818182 160 8.45589986491907e-06 5 0.984842270990486 0.984842270990486 1 10.700825717464 123 173 276 153 275 71 5 160 185 284 31 169 mmu04210 Apoptosis 119/136 Signaling 1.0511559726023e-07 3.39057270882892e-07 150 174.272727272727 161 9.55596384387582e-09 80 1.37684500124794 -1.46093991789428 -1 25.0306301507678 146 181 226 256 80 161 161 146 252 211 97 170 mmu00533 Glycosaminoglycan biosynthesis - keratan sulfate 12/14 Metabolism 1.34460225224815e-06 1.88507962815181e-06 75 153.727272727273 162 1.22236643095152e-07 71 2.1220540366944 -1.74121224517351 -1 34.4409376318189 227 93 73 73 201 229 162 224 81 71 257 171 mmu04728 Dopaminergic synapse 99/134 Signaling 4.57736724091494e-08 3.21850522501729e-07 270 159.818181818182 162 4.16124303286603e-09 14 1.57318740125554 1.78469582867767 1 28.8231154471653 266 14 162 78 29 241 273 214 87 159 235 172 mmu05020 Prion diseases 27/34 Disease 9.54916102320345e-06 1.08375398914134e-05 165 173.818181818182 162 8.68109315623056e-07 43 1.76627217285397 1.40913017227423 1 24.6294232209578 162 253 132 220 250 162 145 43 276 216 53 173 mmu04014 Ras signaling pathway 170/228 Signaling 2.4109253072987e-08 3.21850522501729e-07 255 147.454545454545 163 2.1917503033813e-09 4 1.79774089761023 -1.57914562669768 -1 33.0570774522537 251 107 99 85 4 233 176 172 163 121 211 174 mmu00450 Selenocompound metabolism 16/17 Metabolism 9.23984924822017e-08 3.39057270882892e-07 150 180 165 8.39986330571594e-09 70 1.30838684659426 1.12745493358644 1 23.7443468482614 282 137 174 144 70 279 232 165 147 148 202 175 mmu04071 Sphingolipid signaling pathway 103/122 Signaling 7.45425853332375e-08 3.21850522501729e-07 200 158.727272727273 165 6.77659889626940e-09 13 1.55984821613905 -1.48828464320774 -1 28.571604765395 197 13 191 177 58 277 245 153 165 139 131 176 mmu00670 One carbon pool by folate 18/19 Metabolism 2.5644855066635e-06 3.31874594979982e-06 190 149.818181818182 166 2.3313531782051e-07 56 1.20270007026252 1.21046416277131 1 18.298169589469 56 135 184 189 218 124 129 91 186 170 166 177 mmu03430 Mismatch repair 22/22 Signaling 0.000172696815741961 0.000184986102255434 15 146.272727272727 166 1.57009430620046e-05 15 1.07190093745841 1.10191152292882 1 10.7810494841906 15 211 209 166 264 43 17 90 246 204 144 178 mmu05221 Acute myeloid leukemia 50/55 Disease 1.05138576155043e-06 1.54998107115167e-06 125 152.727272727273 166 9.55805694555252e-08 62 1.33604597851859 -1.26790857233485 -1 21.7029471895525 124 201 215 115 191 102 62 166 84 235 185 179 mmu00790 Folate biosynthesis 11/14 Metabolism 5.54614348992111e-07 9.27600607086222e-07 85 144.909090909091 167 5.04194989826376e-08 77 1.20604241961114 -1.16951980505983 -1 20.2904273743115 83 169 188 190 167 77 85 81 237 189 128 180 mmu00920 Sulfur metabolism 10/11 Metabolism 4.2066855834332e-06 5.11962585898679e-06 155 164.818181818182 167 3.82426693380331e-07 69 1.16534530776183 -1.33649770932292 -1 17.0666159004057 152 142 180 152 232 196 217 69 167 177 129 181 mmu04975 Fat digestion and absorption 18/40 Signaling 9.50370531026073e-07 1.4381268353093e-06 190 160.363636363636 167 8.63973583248782e-08 95 2.27691921854603 -1.97904576654391 -1 37.7928531822708 188 212 95 129 186 156 167 137 137 171 186 182 mmu00280 Valine, leucine and isoleucine degradation 48/56 Metabolism 5.37859411183903e-06 6.33036179418092e-06 240 179.636363636364 169 4.88964296504938e-07 54 1.75685005513771 1.45988884537382 1 25.6849430515358 145 233 169 273 240 139 137 182 54 240 164 183 mmu00360 Phenylalanine metabolism 13/23 Metabolism 6.30730029986262e-07 1.03097022868308e-06 90 151.545454545455 169 5.73391100739796e-08 9 3.03508560968457 -3.85876331606794 -1 51.9307170404455 230 88 31 9 169 264 281 215 14 86 280 184 mmu05166 HTLV-I infection 235/283 Disease 1.73109865446097e-07 4.12578512646531e-07 250 167 169 1.57372617334067e-08 67 1.6024406558353 1.74202915587438 1 28.8727631908514 249 103 160 223 114 169 215 202 190 67 145 185 mmu05220 Chronic myeloid leukemia 69/71 Disease 1.34338922126005e-07 3.54027143235458e-07 195 166.636363636364 170 1.22126300299239e-08 98 1.19629333043305 -1.35109313383598 -1 21.5729946545021 193 116 229 98 102 210 160 164 170 219 172 186 mmu00250 Alanine, aspartate and glutamate metabolism 28/37 Metabolism 1.07880012808031e-06 1.57416753383147e-06 75 152.818181818182 171 9.80727870077356e-08 71 2.49912363117773 1.69440825846541 1 41.2780685976856 254 75 75 74 193 200 171 201 71 120 247 187 mmu05204 Chemical carcinogenesis 36/93 Disease 1.32222355403259e-06 1.87205909135307e-06 125 159.545454545455 171 1.20202213518524e-07 43 2.22605925919555 2.12494756880839 1 36.1895417800426 204 125 65 86 199 254 227 257 124 43 171 188 mmu00040 Pentose and glucuronate interconversions 16/34 Metabolism 6.41194463216818e-07 1.03605433039554e-06 270 176.272727272727 172 5.82904227358474e-08 67 1.92780045814436 2.52465990209088 1 32.6667328909041 268 167 124 95 172 192 140 269 67 181 264 189 mmu04915 Estrogen signaling pathway 78/96 Signaling 1.82660072275477e-07 4.24721794071434e-07 140 163.181818181818 172 1.66054624946593e-08 86 1.54816633378056 1.74490779439513 1 27.809776933301 149 185 172 140 117 137 196 198 223 192 86 190 mmu04950 Maturity onset diabetes of the young 4/27 Disease 8.54127084298745e-07 1.34583896194289e-06 265 174.454545454545 172 8.54127412588805e-08 64 2.96573811890435 -2.67230031926851 -1 49.7280562548064 265 172 285 94 184 235 144 102 134 64 240 191 mmu00260 Glycine, serine and threonine metabolism 33/40 Metabolism 8.56442975781842e-07 1.34583896194289e-06 130 170.727272727273 173 7.78584826535135e-08 62 1.79775359623833 1.73038140980112 1 29.8132919184236 173 130 128 238 178 213 242 62 166 156 192 192 mmu04514 Cell adhesion molecules (CAMs) 105/169 Signaling 7.70663247447705e-14 1.10204844385022e-11 5 142.090909090909 174 7.00602952225209e-15 1 2.48926916582803 -2.15299936816653 -1 78.3780462604698 284 3 2 1 174 214 259 206 161 1 258 193 mmu04623 Cytosolic DNA-sensing pathway 44/64 Signaling 2.12507345298928e-06 2.81375466460618e-06 115 183.272727272727 175 1.93188682335525e-07 111 1.59530031819388 -1.76482607527448 -1 24.8774172722468 111 250 175 275 213 114 114 143 254 209 158 194 mmu05162 Measles 93/136 Disease 1.06869374797992e-07 3.39057270882892e-07 165 175.181818181818 175 9.71539818085313e-09 82 1.90813634588624 -1.78459483604371 -1 35.0132419934561 161 216 161 206 82 170 165 222 175 182 187 195 mmu00760 Nicotinate and nicotinamide metabolism 24/35 Metabolism 4.87049073883561e-07 8.39046659557489e-07 185 161.636363636364 176 4.42771983372193e-08 29 2.18908817806364 2.13616721900991 1 37.7903675760241 181 210 145 158 162 199 134 181 29 176 203 196 mmu04370 VEGF signaling pathway 52/58 Signaling 4.00845217752606e-08 3.21850522501729e-07 25 162.636363636364 177 3.64404750051002e-09 22 1.45295976852981 -1.59142746907224 -1 26.5562203099885 234 54 177 24 22 248 279 208 227 175 141 197 mmu04961 Endocrine and other factor-regulated calcium reabsorption 34/54 Signaling 8.22878266130118e-07 1.3074621339623e-06 180 193.181818181818 177 7.4807143083275e-08 72 1.56049944816461 -1.33768582788465 -1 25.8249209221063 277 72 153 179 177 261 267 175 169 143 252 198 mmu04550 Signaling pathways regulating pluripotency of stem cells 105/137 Signaling 8.64664800808971e-07 1.35133406028069e-06 190 167.636363636364 179 7.86059218770811e-08 95 1.80735849207213 2.01805969319129 1 29.9677719349472 190 195 141 185 179 143 186 149 95 205 176 199 mmu04964 Proximal tubule bicarbonate reclamation 16/22 Signaling 4.74157037197035e-06 5.67401308110259e-06 180 169.272727272727 179 4.31052781028603e-07 16 2.51250232762536 1.74231426332841 1 37.4403970925921 276 237 108 176 237 179 179 16 109 149 196 200 mmu05161 Hepatitis B 121/143 Disease 2.75246824850241e-07 5.46670777133117e-07 145 180 180 2.50224417533619e-08 117 1.52910248089013 -1.55705847407508 -1 26.9701889388192 142 242 219 213 140 157 117 174 203 193 180 201 mmu00051 Fructose and mannose metabolism 30/35 Metabolism 4.33794953806026e-06 5.23482518095036e-06 120 165.454545454545 181 3.94359826512013e-07 37 1.42851510125803 -1.67019577103738 -1 21.070230748007 120 263 204 208 234 131 97 37 181 236 109 202 mmu01212 Fatty acid metabolism 49/52 Metabolism 1.20656758406847e-06 1.74281984365446e-06 160 179.727272727273 183 1.09688022345335e-07 89 1.33239652608469 -1.36873739853891 -1 21.4443116907905 89 158 211 271 194 158 185 145 180 203 183 203 mmu03410 Base excision repair 34/35 Signaling 8.00923558164655e-06 9.16256550540365e-06 235 152.272727272727 184 7.28114976355536e-07 42 1.46430967462599 1.49712966013268 1 20.5853441345172 70 235 206 228 248 56 42 57 233 184 116 204 mmu00750 Vitamin B6 metabolism 6/9 Metabolism 6.26003202602144e-07 1.03097022868308e-06 175 179.454545454545 187 6.26003378948217e-08 85 1.98649151097828 1.84838176708012 1 33.6991371052599 236 171 279 112 173 216 198 85 187 113 204 205 mmu04350 TGF-beta signaling pathway 68/85 Signaling 5.40254974537754e-08 3.21850522501729e-07 210 183.090909090909 187 4.91140898004382e-09 34 1.77124207259451 1.98820063276202 1 32.557441418447 208 187 158 172 34 250 258 219 120 169 239 206 mmu04612 Antigen processing and presentation 60/91 Signaling 1.16081966450325e-05 1.29685321893722e-05 50 161.272727272727 187 1.05529617232629e-06 48 1.32685127075107 -1.25952789175961 -1 17.9927706668102 49 199 202 229 255 48 103 151 264 187 87 207 mmu05150 Staphylococcus aureus infection 27/52 Disease 9.56710929946471e-07 1.44010171560363e-06 180 169.636363636364 187 8.69737587263882e-08 28 2.24985554163573 -2.70945844961853 -1 37.3297727564553 179 220 51 218 187 234 193 178 274 28 104 208 mmu00270 Cysteine and methionine metabolism 37/48 Metabolism 8.15122135853896e-06 9.28784585076551e-06 220 188.272727272727 188 7.41022869071901e-07 93 2.15912053126533 1.64930413188051 1 30.7143302284507 216 203 120 188 249 182 187 266 93 147 220 209 mmu04810 Regulation of actin cytoskeleton 172/214 Signaling 4.09430687505442e-08 3.21850522501729e-07 230 160.181818181818 189 3.72209722841042e-09 23 1.83269032653228 2.07807111758502 1 33.7160498421635 229 105 116 198 23 221 212 189 100 174 195 210 mmu00340 Histidine metabolism 20/25 Metabolism 4.18789783922603e-05 4.60668762314863e-05 230 185.272727272727 190 3.80725232886552e-06 71 2.23734160441203 -2.86054285660588 -1 27.3385039823873 226 165 71 92 259 285 265 190 131 116 238 211 mmu04140 Regulation of autophagy 122/129 Signaling 1.04551484837837e-06 1.54931215873686e-06 80 170.181818181818 190 9.50468495675391e-08 70 1.09927626764141 -1.08052018678316 -1 17.7086690591407 79 243 254 261 190 70 81 89 224 268 113 212 mmu00601 Glycosphingolipid biosynthesis - lacto and neolacto series 16/27 Metabolism 7.21901483994e-08 3.21850522501729e-07 130 177.090909090909 191 6.56274097892964e-09 56 2.46569037647285 -2.41824538618144 -1 45.6512822218639 263 191 61 128 56 282 272 275 129 69 222 213 mmu04152 AMPK signaling pathway 107/126 Signaling 3.54116658180188e-08 3.21850522501729e-07 225 187.909090909091 193 3.21924239891023e-09 16 1.35411107009988 -1.27371614664937 -1 24.6924255341385 167 227 222 257 16 146 173 192 222 252 193 214 mmu04066 HIF-1 signaling pathway 90/107 Signaling 1.44541766707857e-06 2.00674491642947e-06 160 183.181818181818 194 1.31401692430041e-07 112 1.66640968705793 -2.0141299480032 -1 26.7341457412985 157 257 194 209 203 167 153 112 218 212 133 215 mmu01210 2-Oxocarboxylic acid metabolism 16/19 Metabolism 0.000796746608219549 0.000825614238952141 135 197.636363636364 195 7.24577547639094e-05 131 1.71847249221528 2.06048347963848 1 14.5483006033353 131 286 195 247 271 175 151 161 136 223 198 216 mmu05100 Bacterial invasion of epithelial cells 68/76 Disease 1.29541584715252e-07 3.54027143235458e-07 190 197.545454545455 197 1.17765083948173e-08 95 1.26961632896912 -1.09650414498313 -1 22.9466895684013 186 197 230 274 95 186 148 273 138 225 221 217 mmu00620 Pyruvate metabolism 32/38 Metabolism 2.92526214507197e-06 3.71833321551371e-06 275 185.272727272727 198 2.65933275881524e-07 19 1.36627836318515 0.793332793350129 1 20.7051377937783 271 161 198 131 222 259 261 93 19 242 181 218 mmu00860 Porphyrin and chlorophyll metabolism 25/41 Metabolism 5.06667749908464e-06 6.0127376130216e-06 200 206.909090909091 198 4.60608106169002e-07 146 1.73581838086538 2.10035638951003 1 25.4801154765131 198 283 168 258 238 185 197 168 146 202 233 219 mmu05144 Malaria 33/49 Disease 1.6999349091892e-06 2.33741050013515e-06 155 182.272727272727 199 1.5453965661149e-07 28 2.44788250030509 2.15042374376551 1 39.1939846823346 151 206 28 193 205 152 199 285 271 53 262 220 mmu05223 Non-small cell lung cancer 55/58 Disease 4.71499989683474e-08 3.21850522501729e-07 205 170 199 4.28636363444159e-09 31 1.28390767207011 -1.39814245484893 -1 23.3687386412091 199 120 205 149 31 208 159 204 213 217 165 221 mmu05219 Bladder cancer 36/41 Disease 9.18447705042738e-07 1.42442922336765e-06 205 202.818181818182 201 8.34952807702771e-08 133 1.5418637478853 -1.71502972130163 -1 25.3398628200295 247 205 183 192 180 227 133 280 168 215 201 222 mmu04330 Notch signaling pathway 46/49 Signaling 2.46720073373265e-06 3.22200643765999e-06 215 194.363636363636 202 2.24291227326481e-07 123 1.64577441088119 -1.25135608412339 -1 25.4098417941612 214 202 167 202 216 211 190 197 123 173 243 223 mmu00785 Lipoic acid metabolism 3/3 Metabolism 0.000728293508469291 0.000757425248808063 170 216.181818181818 207 7.28532303767103e-05 166 1.21967609819509 -1.8858264408155 -1 10.2145505651684 203 238 281 168 272 207 166 173 269 207 194 224 mmu04120 Ubiquitin mediated proteolysis 133/140 Signaling 1.78533752332244e-06 2.43145967462009e-06 150 206.909090909091 207 1.62303542923267e-07 142 1.01175213885318 1.01306077237476 1 15.6567654408173 148 226 261 259 207 142 156 196 236 270 175 225 mmu00062 Fatty acid elongation 25/27 Metabolism 9.42656668263454e-07 1.43404152725185e-06 285 213.636363636364 209 8.56960974703194e-08 72 1.52659337448249 -1.25067562313926 -1 25.0676381570104 257 209 166 161 185 283 284 261 72 201 271 226 mmu00982 Drug metabolism - cytochrome P450 34/67 Metabolism 4.16662198803656e-06 5.09253798537802e-06 45 172.272727272727 209 3.78784534482036e-07 42 2.501495616065 2.15793349328687 1 37.6138295561034 240 71 42 119 231 209 248 213 192 44 286 227 mmu00500 Starch and sucrose metabolism 21/33 Metabolism 0.000189901225303056 0.00020265578521147 210 195.090909090909 210 1.72652381198641e-05 31 1.68705319776598 -2.18022110885296 -1 17.2557648914436 207 236 181 210 265 215 216 156 31 229 200 228 mmu03020 RNA polymerase 28/30 Signaling 1.2405353548976e-06 1.78287995729002e-06 285 206.181818181818 210 1.12776004946442e-07 66 0.745894043552105 0.827287492214753 1 11.6139624425087 132 285 245 268 195 144 66 169 283 271 210 229 mmu00010 Glycolysis / Gluconeogenesis 50/66 Metabolism 0.00131330611679154 0.00135597671264397 260 216.363636363636 212 0.00011946279639414 143 1.65664934131074 -2.47437861754739 -1 12.9580191622436 202 259 212 207 274 218 237 170 143 259 199 230 mmu04010 MAPK signaling pathway 204/252 Signaling 5.06667808719005e-08 3.21850522501729e-07 270 198.909090909091 213 4.60607109443405e-09 33 1.84236654943851 2.14933151108623 1 33.8984952763376 267 175 126 254 33 228 262 274 198 158 213 231 mmu04630 Jak-STAT signaling pathway 100/159 Signaling 1.07881858917284e-07 3.39057270882892e-07 230 186.636363636364 213 9.8074422006827e-09 84 1.9898181109864 -1.86191971017238 -1 36.5479881621061 213 228 98 227 84 268 239 184 219 85 208 232 mmu04919 Thyroid hormone signaling pathway 102/115 Signaling 4.67444733881786e-07 8.15178011525554e-07 280 210.363636363636 213 4.24949848365526e-08 155 1.27039343880372 1.16374754278822 1 21.6248646830411 279 196 236 231 160 188 266 155 229 213 161 233 mmu03460 Fanconi anemia pathway 49/51 Signaling 2.44677112860618e-06 3.20998414119894e-06 20 160.909090909091 215 2.22433986348425e-07 19 1.19198180392912 1.1824137686431 1 18.1777142701539 41 281 238 260 215 19 19 96 267 224 110 234 mmu04122 Sulfur relay system 8/8 Signaling 1.81383240853155e-06 2.45855956796219e-06 75 164.636363636364 215 1.81383388902785e-07 8 0.90009761287714 -0.90009761287714 -1 13.8237080987477 71 256 283 215 273 107 33 8 278 243 44 235 mmu03450 Non-homologous end-joining 12/13 Signaling 0.000252034722409113 0.000265984983797071 220 171.454545454545 216 2.29148727682296e-05 7 1.09992288456202 1.20228736256915 1 10.5810213645083 137 255 220 216 279 68 7 66 281 256 101 236 mmu05202 Transcriptional misregulation in cancer 125/177 Disease 3.71618402687535e-07 6.85695891410549e-07 225 193.090909090909 216 3.3783496860035e-08 74 2.24329645867784 -2.05706638607739 -1 39.3180204497301 224 241 74 222 151 224 157 279 172 164 216 237 mmu05215 Prostate cancer 81/87 Disease 1.34257893775669e-07 3.54027143235458e-07 285 210.545454545455 216 1.22052638153577e-08 101 1.39400515504631 -1.30962139120654 -1 25.2770947774039 281 151 216 167 101 270 203 264 199 227 237 238 mmu04141 Protein processing in endoplasmic reticulum 155/167 Signaling 2.92708568530726e-07 5.69487419046174e-07 270 220 217 2.66098734068561e-08 126 0.970145791905831 -0.970504623974735 -1 16.7544917509911 126 271 267 278 143 197 169 217 270 277 205 239 mmu05213 Endometrial cancer 47/50 Disease 5.84236092437238e-08 3.21850522501729e-07 220 174.454545454545 218 5.31123734502109e-09 41 1.06803018679178 -0.89586207893741 -1 19.2983630502687 242 59 218 54 41 223 280 167 164 253 218 240 mmu03420 Nucleotide excision repair 44/44 Signaling 3.67057965952109e-05 4.05322695993449e-05 40 165.909090909091 219 3.33694627505949e-06 25 1.03490485902539 1.07913719811387 1 12.3616597004999 36 219 248 234 258 46 25 92 268 261 138 241 mmu00290 Valine, leucine and isoleucine biosynthesis 3/4 Metabolism 3.26562625513874e-08 3.21850522501729e-07 140 176.636363636364 220 3.26562630312815e-09 1 3.82861542781754 -2.40135374612042 -1 71.3492694581066 235 223 272 137 253 253 220 1 32 140 177 242 mmu04060 Cytokine-cytokine receptor interaction 141/270 Signaling 6.2238069712388e-10 4.45002198443574e-08 5 181.090909090909 221 5.65800633909046e-11 4 2.63585338251143 2.49699383758614 1 55.4376142833778 270 178 4 221 125 245 253 255 212 4 225 243 mmu05205 Proteoglycans in cancer 178/205 Disease 3.65502267752055e-08 3.21850522501729e-07 270 199 222 3.32274794385832e-09 19 1.74653165680185 1.93806948699367 1 32.0915258869838 269 177 136 237 19 266 222 262 210 135 256 244 mmu05216 Thyroid cancer 25/29 Disease 1.05112124470571e-05 1.17890461170915e-05 255 205.090909090909 222 9.55569333464954e-07 105 1.35381451856022 1.57940593388115 1 18.5382847660777 222 254 197 154 252 267 238 105 140 230 197 245 mmu05143 African trypanosomiasis 19/36 Disease 4.69272364713806e-05 5.14221824935435e-05 225 222.363636363636 223 4.26620340778204e-06 112 2.14514536199604 1.63089895450206 1 25.8797999790644 223 269 112 214 260 198 209 252 273 153 283 246 mmu05210 Colorectal cancer 56/62 Disease 4.218384269652e-08 3.21850522501729e-07 235 200.272727272727 223 3.83489486412482e-09 24 1.17422279956477 -1.01824361820219 -1 21.3006275217679 231 156 223 181 24 226 163 268 215 241 275 247 mmu04610 Complement and coagulation cascades 46/87 Signaling 9.77853272391097e-07 1.46422008326625e-06 190 193.636363636364 225 8.88957915478525e-08 12 3.12598333017215 2.63049771381873 1 52.1279312859798 225 248 12 199 188 286 233 242 258 51 188 248 mmu00524 Butirosin and neomycin biosynthesis 2/5 Metabolism 0.0320751946542426 0.0325301619543028 285 216.7 225.5 0.00361576677641826 70 0.49888903240643 -0.49888903240643 -1 1.31613014380504 155 239 277 NA 281 150 70 212 286 285 212 249 mmu00310 Lysine degradation 55/59 Metabolism 3.24479507601587e-06 4.05245149231676e-06 180 220.090909090909 226 2.94981805617841e-07 157 1.20024380262005 1.26573306077064 1 17.9567187174227 221 258 239 241 226 274 205 176 176 248 157 250 mmu04146 Peroxisome 75/83 Signaling 4.30327002417491e-06 5.21497977505943e-06 235 152.272727272727 227 3.91207131048282e-07 30 1.43897170446838 -1.34676148858484 -1 21.2375006737719 39 229 227 240 233 66 49 30 231 233 98 251 mmu05203 Viral carcinogenesis 172/231 Disease 5.14126092224175e-07 8.70059540687066e-07 230 197.818181818182 228 4.67387465792939e-08 37 1.35605574968378 -1.36683708932268 -1 23.0281839565958 170 193 243 230 164 177 228 256 228 250 37 252 mmu01230 Biosynthesis of amino acids 63/78 Metabolism 4.07877263066803e-06 5.0065621131805e-06 230 230.818181818182 229 3.70798199334671e-07 156 1.53288518563198 1.25057674584719 1 22.7571871652129 258 188 196 226 229 251 269 277 156 220 269 253 mmu00520 Amino sugar and nucleotide sugar metabolism 42/49 Metabolism 0.000241515027630732 0.000255827029268109 235 182.909090909091 231 2.19583222835744e-05 58 1.40564181056233 -1.2726427933065 -1 13.8243058016094 86 261 233 245 269 127 118 58 242 231 142 254 mmu05169 Epstein-Barr virus infection 183/219 Disease 1.33701824750621e-06 1.88368088072304e-06 195 224.545454545455 232 1.21547187278222e-07 153 1.30201805995155 -1.4087871105699 -1 20.8086090276767 191 225 249 211 200 257 271 240 241 232 153 255 mmu00640 Propanoate metabolism 29/31 Metabolism 1.77364448138387e-06 2.42709244820951e-06 210 215.636363636364 234 1.61240537391026e-07 27 1.28413719659123 -1.34119727530763 -1 20.1007864863083 255 208 199 196 206 236 234 286 27 246 279 256 mmu05010 Alzheimer's disease 150/175 Disease 0.189814189922179 0.191150909569518 275 212.454545454545 234 0.0189536822294687 80 1.29306983365593 1.42391824990415 1 1.85929108425069 80 272 255 276 284 149 110 234 197 273 207 257 mmu00071 Fatty acid degradation 37/49 Metabolism 4.51629564457704e-06 5.42714518634047e-06 235 236.363636363636 236 4.10573174175804e-07 191 1.12964381351395 -1.17226967003264 -1 16.434937598584 217 207 231 244 236 281 274 191 251 237 231 258 mmu00900 Terpenoid backbone biosynthesis 21/23 Metabolism 9.68771298112822e-05 0.000104950223962222 270 233.636363636364 236 8.80739964222024e-06 164 1.13085734716298 0.875686846556955 1 12.2286244914748 183 268 232 236 262 206 164 267 272 244 236 259 mmu05211 Renal cell carcinoma 64/65 Disease 9.21396525604945e-07 1.42442922336765e-06 250 230.545454545455 237 8.37633555910304e-08 181 1.19906318802827 1.361354206045 1 19.5194672099949 248 200 225 248 181 263 230 237 211 247 246 260 mmu04962 Vasopressin-regulated water reabsorption 37/43 Signaling 9.6717743866894e-08 3.39057270882892e-07 285 227.545454545455 238 8.79252255625986e-09 73 1.27142105716394 1.37609008954329 1 23.0497841924502 285 262 224 233 73 238 158 276 235 238 281 261 mmu04910 Insulin signaling pathway 115/141 Signaling 3.5250867242852e-07 6.63272896806294e-07 215 225.909090909091 240 3.20462480828569e-08 148 1.25882671542025 -0.946907299960431 -1 21.7477524802736 272 215 242 242 148 240 224 270 149 269 214 262 mmu04130 SNARE interactions in vesicular transport 31/33 Signaling 6.46041010338605e-06 7.48047485655227e-06 245 155.454545454545 241 5.87311734071058e-07 10 0.95547842171601 -0.869493606963336 -1 13.3849286282515 61 252 241 262 245 23 39 54 266 257 10 263 mmu03013 RNA transport 149/167 Signaling 5.6527940568174e-06 6.59877183775418e-06 265 212.636363636364 242 5.13891689222886e-07 88 0.968046344475805 0.934154500431287 1 13.725154062591 88 273 265 283 242 140 101 187 263 282 215 264 mmu03060 Protein export 27/30 Signaling 5.48931093038325e-06 6.43419232003939e-06 270 243.181818181818 242 4.9902951154888e-07 201 0.863043368778523 -0.490067216427825 -1 12.1728483114836 211 266 240 250 241 242 201 216 275 265 268 265 mmu05322 Systemic lupus erythematosus 49/142 Disease 1.00308150954875e-05 1.13391822818555e-05 235 228 243 9.1189643917216e-07 110 1.92183043229162 -2.39879810460778 -1 26.7628190754591 232 234 110 255 251 258 241 243 262 155 267 266 mmu03022 Basal transcription factors 39/44 Signaling 6.42284644010353e-06 7.46721171491711e-06 60 173.454545454545 244 5.8389683559309e-07 40 0.830998717527936 0.88760724990256 1 11.5336468655312 57 251 250 246 244 58 40 120 255 264 123 267 mmu04068 FoxO signaling pathway 113/132 Signaling 2.15766361817861e-07 4.64746443202075e-07 235 237.454545454545 244 1.96151257253894e-08 126 1.36249814334338 -1.07901323535401 -1 24.2191844964329 233 244 235 232 126 247 276 272 240 254 253 268 mmu05012 Parkinson's disease 126/144 Disease 0.00572842125513603 0.00585117313917465 280 202.636363636364 245 0.000522126516270239 37 1.15686523699704 1.11917958428577 1 6.66215411724816 37 276 257 281 278 118 86 180 245 280 191 269 mmu00630 Glyoxylate and dicarboxylate metabolism 25/29 Metabolism 0.000272326940023992 0.000286343767819344 265 244.181818181818 247 2.47600596227182e-05 201 0.92871825688889 -1.2171372358934 -1 8.71702767042369 201 264 234 235 266 265 247 221 259 245 249 270 mmu03018 RNA degradation 72/81 Signaling 6.71411342625092e-06 7.74288887059582e-06 250 236.363636363636 247 6.10375810630732e-07 170 0.786089979004473 0.800651853124725 1 10.8290413237384 189 247 259 267 246 173 170 250 280 275 244 271 mmu00020 Citrate cycle (TCA cycle) 29/32 Metabolism 0.272193091538587 0.27314815501767 285 241 249 0.0284704473847581 176 0.97013361379943 0.802339597047185 1 0.748548859480442 176 284 247 249 283 193 200 281 216 263 259 272 mmu01200 Carbon metabolism 99/118 Metabolism 1.0780801519482e-06 1.57416753383147e-06 265 241.454545454545 249 9.80073345679201e-08 171 1.17285250847336 0.912663154228508 1 18.9265742607344 261 245 251 272 192 249 246 246 171 262 261 273 mmu00130 Ubiquinone and other terpenoid-quinone biosynthesis 9/11 Metabolism 1.0421830858634e-05 1.17348174235012e-05 275 230.909090909091 250 1.04218797355079e-06 100 0.96103148687807 0.715709537799232 1 12.9218213993958 278 100 270 243 254 273 250 129 221 249 273 274 mmu05016 Huntington's disease 166/194 Disease 0.00200922896572609 0.00206704850430813 270 206.727272727273 250 0.000182824210533021 63 1.15526597537345 1.14188927961101 1 8.16793473148046 63 270 263 266 276 126 104 171 250 279 206 275 mmu01100 Metabolic pathways 1009/1315 Metabolism 1.20389865198248e-07 3.50999444101379e-07 255 227.636363636364 251 1.20389871720422e-08 98 1.64657643926698 -1.71479234537101 -1 30.0268157005541 262 224 282 251 98 255 251 230 133 258 260 276 mmu03015 mRNA surveillance pathway 85/96 Signaling 6.8794680827871e-06 7.90171836014904e-06 280 242.909090909091 253 6.25408145017352e-07 145 1.05021318945692 1.12772582448522 1 14.7226872803668 228 279 253 277 247 219 207 265 145 274 278 277 mmu00510 N-Glycan biosynthesis 45/49 Metabolism 1.83728417403277e-06 2.4786003479876e-06 260 237 255 1.67025973491288e-07 121 1.47662330735287 1.6161344420368 1 23.2005067793041 256 249 221 212 208 269 256 283 121 255 277 278 mmu00970 Aminoacyl-tRNA biosynthesis 44/66 Signaling 1.45479277859252e-05 1.61895227500958e-05 260 255.818181818182 256 1.32254763525611e-06 227 0.724389791573771 0.580920399951373 1 9.23928553709573 250 260 252 265 256 276 244 239 279 266 227 279 mmu03050 Proteasome 41/45 Signaling 0.0479923797857314 0.0485011329283363 285 235.454545454545 256 0.0044611321645583 141 0.577165645949802 0.477051077146326 1 1.3635694929335 141 282 256 282 282 163 141 233 282 278 250 280 mmu03010 Ribosome 132/177 Signaling 1.72423074462356e-05 1.91135656186953e-05 285 228.272727272727 257 1.56749478025399e-06 93 0.60454931471284 -0.551023686846537 -1 7.44530644321396 93 278 264 284 257 181 128 229 285 286 226 281 mmu03008 Ribosome biogenesis in eukaryotes 73/116 Signaling 0.00530656365291318 0.00543970324277122 280 237.636363636364 260 0.000483582442771168 135 0.916949920660606 0.813849542808696 1 5.19078857975337 135 280 260 269 277 201 202 209 260 276 245 282 mmu04922 Glucagon signaling pathway 77/102 Signaling 5.79044535763569e-08 3.21850522501729e-07 280 236.909090909091 260 5.26404137276493e-09 40 1.17898033673672 1.1426790558311 1 21.3903310086912 280 246 246 263 40 280 282 235 208 260 266 283 mmu03040 Spliceosome 128/133 Signaling 0.000119909817885221 0.000128925593666065 270 198.454545454545 263 1.09014867276515e-05 48 0.664792697593886 0.682945058236674 1 6.67034138993491 53 275 266 270 263 98 48 159 284 283 184 284 mmu00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 24/25 Metabolism 0.38156054184512 0.38156054184512 265 262.545454545455 267 0.0427463800238614 223 0.69071731056946 -0.790368717728378 -1 0 286 265 244 264 285 232 223 271 277 267 274 285 mmu04932 Non-alcoholic fatty liver disease (NAFLD) 131/151 Disease 0.000719196342287451 0.000750693992314639 275 256.363636363636 270 6.54028691430589e-05 183 1.13119849324131 -1.16358278116696 -1 9.42541429682026 273 274 258 280 270 222 183 251 265 272 272 286 mmu00190 Oxidative phosphorylation 119/134 Metabolism 0.0230262099619537 0.0234359290004227 280 241.636363636364 276 0.00211552768138287 122 1.03248888196791 0.782444608291214 1 4.04861124073894 163 277 262 279 280 178 122 284 256 281 276