Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance 1 M18391 GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE.html The action of a molecule that contributes to the structural integrity of a muscle fiber. 39/67 Gene Ontology MF GO:0008307 3.53145609350848e-07 2.15894823966498e-06 10 227.333333333333 49 1.07013839338546e-08 6 2.7437119574136 1.95097968607395 0.333333333333333 15.2429575236103 2 M17918 GO_LIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of lipids into, out of or within a cell, or between cells. 97/169 Gene Ontology MF GO:0005319 5.51341558250305e-08 9.26253817860512e-07 40 200.545454545455 57 1.67073203935941e-09 4 2.37595620199603 -2.31590469169052 -1 19.1553354291073 3 M18411 GO_CATION_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 53/70 Gene Ontology MF GO:0019829 2.35749609070913e-07 2.15894823966498e-06 55 267.181818181818 65 7.14392836417475e-09 10 1.59543156496996 -1.5756937520275 -1 8.32133638176493 4 M18961 GO_CHEMOREPELLENT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOREPELLENT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. 34/41 Gene Ontology MF GO:0045499 4.81323958193707e-07 2.15894823966498e-06 5 194.30303030303 70 1.45855778945432e-08 1 2.50241321250899 2.72236651219183 1 17.0355598844103 5 M18662 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. 19/31 Gene Ontology MF GO:0043395 7.52311683268111e-06 1.08955485162968e-05 10 263.69696969697 75 2.27974068906832e-07 7 2.7312927870876 2.61633856539403 1 14.927412759806 6 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 55/67 Gene Ontology MF GO:0004714 9.41757067527279e-07 2.57450748637635e-06 50 162.636363636364 76 2.85381059861441e-08 5 2.191373797952 2.19690117561805 1 15.9174261844351 7 M18934 GO_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVITY.html Catalysis of the hydrolysis of a lipid or phospholipid. 81/132 Gene Ontology MF GO:0016298 8.3874866240306e-07 2.49851622271267e-06 30 169 77 2.54166364695099e-08 14 2.0937439577075 -1.09284148866681 -0.333333333333333 13.8757759183247 8 M19008 GO_PEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 43/145 Gene Ontology MF GO:0001653 8.0804488721393e-09 1.55548640788682e-07 95 201.030303030303 77 2.44862087993844e-10 22 2.77693056033382 3.00405838729314 1 24.2822356566884 9 M18700 GO_CORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 34/48 Gene Ontology MF GO:0015026 9.65466185354527e-07 2.59328707926623e-06 85 105.393939393939 79 2.92565647664905e-08 1 2.05874555098918 2.18615684490986 1 14.5906398398547 10 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 70/85 Gene Ontology MF GO:0019199 1.20130420537142e-06 2.94431057231617e-06 40 160.727272727273 80 3.64031789415831e-08 3 2.10002289624817 2.11934796465364 1 15.1628336492978 11 M18041 GO_ANKYRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANKYRIN_BINDING.html Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. 30/49 Gene Ontology MF GO:0030506 7.06789955966655e-07 2.38817198336225e-06 85 277.454545454545 82 2.1417884793146e-08 9 2.45202736508435 2.58025013221276 1 13.0583139756891 12 M18099 GO_WNT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_PROTEIN_BINDING.html Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. 30/33 Gene Ontology MF GO:0017147 1.97156286685991e-06 3.82715144743394e-06 10 238.393939393939 85 5.97443864090171e-08 2 2.04157438835376 1.2208567779466 0.333333333333333 12.7308077371542 13 M18118 GO_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_LIPASE_ACTIVITY.html Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. 10/30 Gene Ontology MF GO:0004806 5.29634611738955e-07 2.21690044979278e-06 15 147.424242424242 93 1.60495378104612e-08 2 2.92954368152616 -1.6079877724258 -0.333333333333333 17.596084980777 14 M18166 GO_NITRIC_OXIDE_SYNTHASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_SYNTHASE_BINDING.html Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. 32/45 Gene Ontology MF GO:0050998 1.25389836209934e-06 3.02246775832134e-06 10 194.575757575758 95 3.79969431638904e-08 3 2.38219549490141 2.89287040149407 1 13.6132609538791 15 M19120 GO_SEMAPHORIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with semaphorin receptors. 27/29 Gene Ontology MF GO:0030215 1.01860689054655e-07 1.65121538046493e-06 5 247.727272727273 96 3.086687699553e-09 1 2.33543072896848 2.65014219651797 1 13.549531261249 16 M18566 GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. 15/29 Gene Ontology MF GO:0015665 2.52132129748328e-07 2.15894823966498e-06 320 185.090909090909 96 7.6403685021348e-09 7 3.08689168112593 -3.06575980450791 -1 18.7840438250036 17 M19010 GO_FRIZZLED_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRIZZLED_BINDING.html Interacting selectively and non-covalently with the frizzled (fz) receptor. 32/44 Gene Ontology MF GO:0005109 1.9709398787371e-06 3.82715144743394e-06 45 185.181818181818 99 5.9725507944967e-08 7 2.41338269248423 2.4898852312673 1 14.4475484141953 18 M18989 GO_ALPHA_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_ACTININ_BINDING.html Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. 17/31 Gene Ontology MF GO:0051393 1.68623680611501e-07 2.15894823966498e-06 5 181.363636363636 100 5.10980892114118e-09 2 2.2339518964462 2.40152357291776 1 13.4961670530033 19 M18211 GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY.html Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 169/1410 Gene Ontology MF GO:0004930 1.09295856851032e-20 8.41578097752945e-19 10 169.090909090909 107 3.31199566215247e-22 2 2.3021738393811 2.49250753971862 1 60.3436856232344 20 M18305 GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 8/20 Gene Ontology MF GO:0005328 4.0627652024149e-07 2.15894823966498e-06 55 225.090909090909 107 1.35425533340269e-08 1 2.58484611752153 2.51708513087837 1 16.0888175027307