Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M18293 GO_MANNOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSE_BINDING.html Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. 10/23 Gene Ontology MF GO:0005537 8.45703074010491e-05 0.000840246925145908 35 259.363636363636 34 7.68850532248494e-06 5 0.63236185804693 -0.63236185804693 -1 6.58130228418873 25 382 508 238 16 34 30 32 916 667 5 2 M18226 GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. 65/94 Gene Ontology MF GO:0008081 5.37621415994763e-05 0.000591383557594239 50 113.909090909091 49 4.88758685890939e-06 19 1.43410430281317 1.59742272646507 1 15.6991685626446 46 24 61 59 691 49 80 19 165 34 25 3 M18409 GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. 10/15 Gene Ontology MF GO:0048531 5.09827170838353e-05 0.000567566633559805 15 72.6363636363636 53 4.63489987215745e-06 11 1.53984684620484 -1.48462561163774 -1 16.9518895115215 53 122 185 27 11 89 11 15 88 152 46 4 M17970 GO_COMPLEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_BINDING.html Interacting selectively and non-covalently with any component or product of the complement cascade. 17/27 Gene Ontology MF GO:0001848 4.57763616055185e-06 6.93399313499985e-05 5 167.363636363636 60 4.16149607769749e-07 1 1.53500117537658 1.50788836638869 1 21.6585113293441 35 238 186 404 4 60 23 1 567 310 13 5 M18180 GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY.html Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. 19/21 Gene Ontology MF GO:0004029 7.2570760449632e-05 0.000745059807282888 60 64.8181818181818 60 6.59755949370622e-06 4 1.53965721722505 -1.54073830250161 -1 16.3318358856882 42 85 130 77 14 4 26 154 58 63 60 6 M18069 GO_MANNOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. 15/15 Gene Ontology MF GO:0015923 0.000175130839105604 0.00142893051893132 65 175.545454545455 64 1.59222529033775e-05 3 0.839973133893354 -0.973722638811786 -1 8.0920993658639 64 101 445 28 28 258 290 61 3 615 38 7 M18813 GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS.html Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 54/63 Gene Ontology MF GO:0016879 0.00113716758250795 0.00547261899081953 35 154.090909090909 72 0.000103432345793125 3 1.03907486363531 -1.01053034663157 -1 7.95784161504712 32 32 428 178 72 3 16 89 252 539 54 8 M18051 GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. 8/11 Gene Ontology MF GO:0019203 9.50237356536897e-05 0.000886888199434438 5 142.727272727273 75 9.50277991778935e-06 5 1.42072152669075 -1.42072152669075 -1 14.7031893243273 50 131 816 92 20 5 5 177 22 177 75 9 M18934 GO_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVITY.html Catalysis of the hydrolysis of a lipid or phospholipid. 81/132 Gene Ontology MF GO:0016298 0.000328046942732351 0.00221252098601965 70 143.454545454545 77 2.98268971602697e-05 16 1.38128463243919 1.62047342308536 1 12.4318229653071 126 16 67 66 641 104 222 30 197 77 32 10 M19008 GO_PEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 43/145 Gene Ontology MF GO:0001653 4.33899227672156e-07 8.35256013268899e-06 45 260.545454545455 77 3.94453921135263e-08 40 1.66667298518398 1.66437260118006 1 28.721511096331 77 421 41 540 800 67 42 40 576 61 201 11 M18994 GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. 70/84 Gene Ontology MF GO:0050660 0.000865346947626701 0.00449202572812961 30 121.818181818182 78 7.86988645759438e-05 13 1.13905518900855 -1.2423098038438 -1 9.05763284955906 29 21 349 82 66 13 78 84 354 237 27 12 M18700 GO_CORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 34/48 Gene Ontology MF GO:0015026 5.59178531404835e-05 0.000607859956491844 20 83.2727272727273 79 5.0835704060592e-06 2 1.53791619915168 1.62387555153876 1 16.7750190474449 18 206 95 97 227 2 14 5 79 157 16 13 M19126 GO_OPSONIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPSONIN_BINDING.html Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. 16/21 Gene Ontology MF GO:0001846 2.46978059231335e-07 4.96103753760334e-06 60 147.363636363636 79 2.24525533597978e-08 1 1.57481091522127 1.55338521192547 1 28.3472450785201 58 237 164 278 1 50 79 27 412 293 22 14 M17999 GO_ACID_AMINO_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_AMINO_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 21/27 Gene Ontology MF GO:0016881 0.000431749090641421 0.00273243945036077 85 241.545454545455 81 3.92576222280898e-05 31 0.850212031488301 -0.860315613620218 -1 7.37805024247349 81 81 469 279 48 31 56 104 757 690 61 15 M18419 GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. 18/23 Gene Ontology MF GO:0070003 0.000310966534169104 0.00213857856113643 5 159.818181818182 81 2.82736815908065e-05 4 0.697106975645691 -0.697106975645691 -1 6.2970278024648 5 78 582 81 85 23 27 91 4 658 124 16 M17887 GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. 11/16 Gene Ontology MF GO:0004115 0.000249163176976172 0.00180086618024421 85 137.363636363636 82 2.26537636975946e-05 18 1.69135960531209 1.47386600411605 1 15.7415947740679 39 541 162 272 83 53 76 18 82 104 81 17 M18621 GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR.html Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. 10/11 Gene Ontology MF GO:0016884 0.00012885070203935 0.0011447889296573 105 177.636363636364 83 1.17143862955145e-05 2 1.16479015662632 -1.16479015662632 -1 11.6116035629369 51 553 415 101 22 83 62 45 2 519 101 18 M18081 GO_ADRENERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_ACTIVITY.html Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. 4/26 Gene Ontology MF GO:0004935 1.07768840060956e-05 0.00014643883561224 90 142.909090909091 86 1.07769362700053e-06 7 2.18322295791425 -2.64534528948898 -1 28.4075543585111 86 138 819 32 7 100 124 21 20 153 72 19 M19026 GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY.html Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 6/26 Gene Ontology MF GO:0001637 0.00106567852236571 0.00520998388712127 20 233.818181818182 87 0.000106618991937736 6 1.9928054724623 1.9928054724623 1 15.4289012611001 20 136 906 87 805 21 13 59 287 232 6 20 M17849 GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. 15/25 Gene Ontology MF GO:0004112 0.000112229986949591 0.00101667164648453 170 112.909090909091 88 1.02032466015995e-05 11 1.62983979320804 1.57501853263177 1 16.5426232676533 167 102 117 70 21 350 216 11 48 52 88 21 M18564 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). 16/21 Gene Ontology MF GO:0016755 0.000312454659906297 0.00213857856113643 40 122.909090909091 88 2.84090040960573e-05 9 1.55666571105503 -1.39573489015996 -1 14.0914145838175 36 88 105 9 42 14 33 473 273 137 142 22 M17910 GO_VITAMIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 28/33 Gene Ontology MF GO:0051183 0.000527656297252256 0.00316593778351354 310 242.636363636364 91 4.79802631672521e-05 18 1.52507210164779 -1.64663264456769 -1 12.9224219163663 309 63 71 18 680 421 634 51 91 70 261 23 M18913 GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY.html Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 10/62 Gene Ontology MF GO:0008227 0.000273815503502303 0.00191670852451612 255 200.181818181818 91 2.48954171777572e-05 19 1.80953731969759 -1.90130003421238 -1 16.6767808124802 253 116 72 19 39 643 623 82 24 91 240 24 M19207 GO_ACYL_COA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. 17/19 Gene Ontology MF GO:0003995 0.00128755119639024 0.00580340149007114 55 223.454545454545 92 0.000117118668583677 37 0.630452345192472 -0.64677858934061 -1 4.76425510386945 286 236 644 52 79 55 191 92 37 747 39 25 M18118 GO_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_LIPASE_ACTIVITY.html Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. 10/30 Gene Ontology MF GO:0004806 0.00239928277838733 0.00893926325495923 15 94.0909090909091 93 0.000218354854333662 13 1.85867289623158 1.80177579821117 1 12.9086525332117 44 126 146 182 133 72 60 93 13 151 15 26 M18711 GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. 55/83 Gene Ontology MF GO:0035004 0.00170295114022509 0.00701544965029157 225 250.818181818182 94 0.000154933706518339 29 1.18478773261745 1.1921207790035 1 8.64317045873916 222 29 82 47 713 35 63 811 266 94 397 27 M18848 GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). 19/28 Gene Ontology MF GO:0015295 0.00310577545349822 0.0108291944114429 20 193 97 0.000282742601078287 18 0.97677187220746 -0.991938470726146 -1 6.49592916280736 185 87 417 50 492 18 18 81 97 569 109 28 M18089 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 7/11 Gene Ontology MF GO:0016813 0.000596139699475886 0.00348628533111214 15 170.363636363636 98 5.96299682025002e-05 13 1.65767741884299 -1.65767741884299 -1 13.8124599880685 13 267 821 122 247 44 15 28 98 155 64 29 M19163 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. 27/82 Gene Ontology MF GO:0016709 0.000469726495095457 0.00289351520978802 75 234.909090909091 98 4.27115288498614e-05 53 1.60411659771168 -1.82281382227745 -1 13.8063450902893 72 434 70 408 89 194 272 53 801 93 98 30 M18052 GO_VIRUS_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRUS_RECEPTOR_ACTIVITY.html Combining with a virus component and mediating entry of the virus into the cell. 70/110 Gene Ontology MF GO:0001618 0.000625094647274621 0.00361105641729824 25 158.090909090909 100 5.68429389597406e-05 12 1.34514653466456 1.45938846222309 1 11.1339786812965 23 309 88 275 350 12 141 26 396 100 19 31 M18247 GO_ICOSANOID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_RECEPTOR_ACTIVITY.html Combining with an icosanoid to initiate a change in cell activity. 7/14 Gene Ontology MF GO:0004953 7.15097046931016e-06 0.000106572527639397 65 238.818181818182 100 7.15099348078476e-07 2 1.86413623487767 1.86413623487767 1 25.1259205621188 62 624 838 452 197 24 8 2 100 278 42 32 M18333 GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. 26/39 Gene Ontology MF GO:0005520 2.59925303588827e-05 0.000320227974021435 5 245.636363636364 100 2.36298522365089e-06 3 1.37805107389595 1.44699287208549 1 16.3315034381918 6 516 100 652 707 17 37 3 538 122 4 33 M19165 GO_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_ACTIVITY.html Catalysis of the hydrolysis of a glycerophospholipid. 69/102 Gene Ontology MF GO:0004620 0.000109048531014907 0.000997632105522513 105 146.727272727273 101 9.91399424133005e-06 7 1.31340508111752 1.51605121240387 1 13.3627733733513 101 25 101 266 463 57 143 10 313 128 7 34 M18860 GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. 16/18 Gene Ontology MF GO:0034979 0.0062759068742349 0.017156621159151 95 201.454545454545 102 0.000572171080749446 29 0.900112163329207 -0.908179680691237 -1 5.37328577301663 93 240 568 159 209 29 90 102 64 631 31 35 M18672 GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). 18/36 Gene Ontology MF GO:0005343 0.000404505272804837 0.00260501519564382 300 172.545454545455 104 3.67799697032128e-05 69 1.43986965955534 1.47749201081585 1 12.6132917894394 296 82 69 94 99 413 177 261 104 75 228 36 M18025 GO_RACEMASE_AND_EPIMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RACEMASE_AND_EPIMERASE_ACTIVITY.html Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. 16/18 Gene Ontology MF GO:0016854 4.98052977091391e-05 0.000561220671746885 10 141.818181818182 106 4.52785684324002e-06 6 1.24120658964623 1.37024494534445 1 13.6800939459938 175 103 367 88 10 300 199 6 12 194 106 37 M18770 GO_TRANSCRIPTION_COACTIVATOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_BINDING.html Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 11/12 Gene Ontology MF GO:0001223 0.000761778770449569 0.00411627826839416 35 172.545454545455 109 6.92766067501858e-05 24 1.37026539294386 1.27600998101045 1 11.0776730015341 34 119 281 109 765 41 24 31 150 274 70 38 M19042 GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). 10/23 Gene Ontology MF GO:0005416 0.00199561372953939 0.00778036745187508 95 250.909090909091 110 0.000181584204296827 57 1.44818416742079 1.65328031490069 1 10.3490102951596 339 114 86 91 94 669 469 628 110 57 103 39 M19109 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS.html Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). 48/59 Gene Ontology MF GO:0016763 7.40363735783039e-05 0.000751753947102778 5 212.090909090909 111 6.7308059303779e-06 1 0.913441922529086 -0.871518796248283 -1 9.66736874632046 111 38 632 136 428 1 48 99 175 664 1 40 M18566 GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. 15/29 Gene Ontology MF GO:0015665 0.00577426225782821 0.0160222772559558 625 292.181818181818 116 0.000526315789473684 24 1.4802121672747 -1.47616249953006 -1 9.00122303829592 622 104 108 24 517 508 723 322 116 79 91 41 M18865 GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. 42/52 Gene Ontology MF GO:0008375 5.77899060070073e-05 0.000620905501749706 40 120.363636363636 119 5.25376582692046e-06 7 1.53499652588339 -1.52367155297063 -1 16.6950482303704 265 46 134 7 12 36 235 213 39 119 218 42 M18974 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 45/73 Gene Ontology MF GO:0016903 0.0030851424650844 0.0107979986277954 100 142.090909090909 121 0.000280861580821345 51 1.50332683704208 -1.45421032466261 -1 10.0172103478263 99 198 121 183 107 56 51 274 278 67 129 43 M19108 GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. 10/11 Gene Ontology MF GO:0008195 0.00405724586840398 0.0130623525519348 5 194.545454545455 121 0.000369522511626098 1 1.28976984905661 1.49872368855698 1 8.22858116116306 342 113 148 4 121 527 603 132 1 92 57 44 M18188 GO_FAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 13/15 Gene Ontology MF GO:0071949 0.0042508849356516 0.0134514304128153 190 158.454545454545 124 0.000387192806370529 18 0.898271553675582 -1.02225665387452 -1 5.68461305819274 188 107 502 49 124 136 118 157 18 320 24 45 M18918 GO_SIGNALING_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. 68/96 Gene Ontology MF GO:0035591 0.0345405505779077 0.0622133893450033 205 178.454545454545 127 0.00319046122355862 20 1.25917164470795 1.21463045782881 1 5.13383391958127 198 20 205 72 374 76 127 202 49 117 523 46 M18747 GO_BETA_AMYLOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_BINDING.html Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. 32/39 Gene Ontology MF GO:0001540 0.00577426225782821 0.0160222772559558 265 147.727272727273 128 0.000526315789473684 25 1.43689464999459 1.57522952975321 1 8.73709760430429 264 205 119 25 313 110 128 140 183 98 40 47 M18373 GO_AMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BINDING.html Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. 6/11 Gene Ontology MF GO:0043176 0.00180709910465274 0.00725982422912665 440 220.272727272727 130 0.000180857031195125 6 1.06149762540412 -0.848486054662994 -1 7.68761713347766 438 130 850 26 93 152 77 74 6 383 194 48 M19037 GO_ACID_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. 10/12 Gene Ontology MF GO:0003993 8.86386301064812e-05 0.000854124391762533 10 191.181818181818 132 8.05838196215738e-06 8 1.15109240137536 -1.31428091683405 -1 11.9720778466772 132 470 411 283 169 20 36 8 9 521 44 49 M18063 GO_ANION_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). 32/65 Gene Ontology MF GO:0015296 2.11823976229607e-05 0.000268116923337201 60 269.545454545455 135 1.92569105250128e-06 51 1.52812940716502 1.59702743563625 1 18.5130867076527 575 51 57 79 135 613 682 148 94 59 472 50 M18900 GO_PROTEIN_TYROSINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_BINDING.html Interacting selectively and non-covalently with protein tyrosine kinase. 66/84 Gene Ontology MF GO:1990782 0.00335537662048304 0.0115255315885737 20 197 135 0.000305500463465007 16 1.11335374194148 1.11483093483231 1 7.30530483837727 26 310 260 287 546 16 19 115 406 135 47 51 M17880 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. 38/59 Gene Ontology MF GO:0016620 0.000414404771029032 0.00264075867883328 50 158.727272727273 137 3.76802592098927e-05 47 1.53156482735848 -1.54962356656934 -1 13.3873023645527 137 50 149 186 47 121 120 295 359 123 159 52 M18189 GO_CLATHRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_BINDING.html Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. 50/71 Gene Ontology MF GO:0030276 0.00184719595215102 0.00738191632224074 90 419 137 0.000168068067931257 8 1.25927552246906 1.2496115717786 1 9.09351416174478 823 30 137 8 90 909 915 872 53 88 684 53 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 55/67 Gene Ontology MF GO:0004714 2.66344142384001e-05 0.000323818404687917 60 265 138 2.42133969952586e-06 33 1.41063837264782 1.47033346617327 1 16.6950749552388 138 416 59 453 786 80 285 57 546 62 33 54 M18836 GO_CARBONATE_DEHYDRATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBONATE_DEHYDRATASE_ACTIVITY.html Catalysis of the reaction: H2CO3 = CO2 + H2O. 8/14 Gene Ontology MF GO:0004089 0.00101911671532115 0.00509662729413008 10 242.090909090909 139 0.00010195843866992 4 1.58766387630052 1.58766387630052 1 12.3387552661183 10 262 886 352 687 22 4 43 139 178 80 55 M18684 GO_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. 28/59 Gene Ontology MF GO:0008146 0.000383022344240394 0.00251001876651152 215 165.181818181818 142 3.48262768269994e-05 20 1.52117985403951 1.29745423454567 1 13.4102937616947 43 214 92 441 211 69 40 20 312 142 233 56 M18847 GO_FUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 7/11 Gene Ontology MF GO:0008417 0.000125622280059115 0.00112694161917109 150 218.727272727273 146 1.25629382054923e-05 12 1.39243033127393 1.66382653984165 1 13.9179255771695 146 268 887 84 68 323 200 12 23 281 114 57 M18148 GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. 12/17 Gene Ontology MF GO:0017110 0.00690562564200919 0.0183356267046451 150 233.454545454545 147 0.000629763417316045 38 1.48503454057299 -1.48503454057299 -1 8.73520804632568 125 466 426 237 147 146 132 139 38 411 301 58 M18138 GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT.html The action of a molecule that contributes to the structural integrity of the extracellular matrix. 66/94 Gene Ontology MF GO:0005201 1.71248430158364e-09 7.19243406665131e-08 20 230.272727272727 148 1.5568039117424e-10 2 1.63197193612295 1.65818219130414 1 39.5685513615489 2 502 18 449 305 148 145 131 651 20 162 59 M19106 GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). 29/59 Gene Ontology MF GO:0015370 6.10737720150262e-08 1.48505698268116e-06 150 125.909090909091 148 5.55216124640757e-09 13 1.62238175908149 1.5645461256203 1 32.0906854611885 148 57 34 13 187 173 101 310 177 24 161 60 M17988 GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). 9/19 Gene Ontology MF GO:0005283 0.00670913147890459 0.0179168713482886 150 216.818181818182 149 0.000672947356850286 61 1.50592728944974 1.65328031490069 1 8.90976255377742 149 123 810 191 155 247 61 374 128 76 71 61 M18879 GO_PEPTIDOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDOGLYCAN_BINDING.html Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. 7/26 Gene Ontology MF GO:0042834 6.45333792304187e-05 0.000669986993358504 25 350.363636363636 150 6.45352533576826e-06 1 0.995589886714424 0.995589886714424 1 10.7080612583075 24 626 892 739 150 9 1 71 785 423 134 62 M19199 GO_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 159/222 Gene Ontology MF GO:0019838 3.64085919354998e-06 5.60692315806697e-05 15 301.090909090909 150 3.30987747177535e-07 15 1.23317827410777 1.30201994667748 1 17.7814998611193 15 701 49 707 538 161 150 34 789 101 67 63 M18584 GO_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 29/36 Gene Ontology MF GO:0008378 0.0145626484420625 0.0312927608382924 115 216.727272727273 151 0.00133272246469245 65 1.50873773437216 -1.29827482210744 -1 7.6854391447577 387 65 120 114 658 174 203 151 121 111 280 64 M18782 GO_NADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_BINDING.html Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. 40/65 Gene Ontology MF GO:0050661 0.000184218039488801 0.00145485015801412 115 226.636363636364 151 1.67484969892689e-05 29 1.40425784210692 -1.48882794387752 -1 13.507347492741 113 423 237 130 29 139 279 103 592 297 151 65 M18753 GO_PROLINE_RICH_REGION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROLINE_RICH_REGION_BINDING.html Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. 25/26 Gene Ontology MF GO:0070064 0.00670393572717707 0.0179168713482886 95 239.636363636364 154 0.000611313802722322 64 0.984626857907448 0.94298025259577 1 5.81710873559487 94 341 610 154 283 98 64 105 118 566 203 66 M18212 GO_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_ACTIVITY.html Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 13/14 Gene Ontology MF GO:0004707 0.00142469906298987 0.0062521612384794 85 277.363636363636 157 0.000129602047444131 10 0.633167567213117 -0.591310135093457 -1 4.7153156545529 83 373 540 330 157 85 85 68 612 708 10 67 M18707 GO_CHEMOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_BINDING.html Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 14/31 Gene Ontology MF GO:0019956 0.000214580484340923 0.00162518334041814 115 317.545454545455 157 1.95092196951547e-05 14 2.2696745295236 2.2696745295236 1 21.4759511752715 112 611 157 374 900 74 38 14 667 477 69 68 M18800 GO_SOLUTE_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). 60/113 Gene Ontology MF GO:0015294 1.21626089161078e-06 2.16120204586224e-05 45 310.636363636364 161 1.10569233092373e-07 11 1.42847458081273 -1.3417948230924 -1 22.6100860425137 898 27 45 11 161 278 577 404 160 43 813 69 M19220 GO_COENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BINDING.html Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 172/214 Gene Ontology MF GO:0050662 0.000711514301891862 0.00389017286951527 105 167.454545454545 162 6.47040473596922e-05 39 1.14825491150127 -1.18480985557064 -1 9.37462387742934 102 162 382 71 60 39 243 150 220 224 189 70 M18123 GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. 37/60 Gene Ontology MF GO:0015179 0.0057114692165268 0.0160222772559558 895 343.909090909091 163 0.000520577364238966 49 1.33901436749044 1.36240590754384 1 8.14027964891558 891 49 97 80 163 410 517 684 153 113 626 71 M18211 GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY.html Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 169/1410 Gene Ontology MF GO:0004930 3.64319522836773e-21 1.12210413033726e-18 10 199.181818181818 163 3.31199566215247e-22 2 1.47867570673585 1.52691525870644 1 90.1229043577284 120 163 2 440 503 10 181 173 582 6 11 72 M19082 GO_MONOSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 60/85 Gene Ontology MF GO:0048029 8.23088632116244e-05 0.000826667278342837 155 172.818181818182 164 7.48290389129787e-06 15 1.16832201352752 -1.14537895298119 -1 12.2079479700039 152 28 274 36 15 61 164 207 580 179 205 73 M17938 GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 2/14 Gene Ontology MF GO:0099528 0.0060176192040721 0.0165978511777989 140 248.4 166.5 0.00067041939509955 11 2.39685896943542 2.39685896943542 1 14.4656342283897 140 391 807 NA 268 193 35 123 11 401 115 74 M18678 GO_CHEMOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_ACTIVITY.html The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 23/62 Gene Ontology MF GO:0008009 0.00351529409429121 0.0118979184729856 35 365.636363636364 169 0.000320083967529194 31 1.72442999932748 1.58992623733143 1 11.2473352715706 31 725 89 687 562 111 109 629 756 169 154 75 M18245 GO_SCAVENGER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAVENGER_RECEPTOR_ACTIVITY.html Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). 32/49 Gene Ontology MF GO:0005044 1.39881375004134e-06 2.43868661327962e-05 125 205.181818181818 171 1.27164967222008e-07 29 1.72835731085504 1.74022111995068 1 27.0538119919162 121 210 46 73 435 231 259 127 555 29 171 76 M18548 GO_LIPOPOLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with lipopolysaccharide. 19/32 Gene Ontology MF GO:0001530 0.00175323504065841 0.00710009981117256 135 286 171 0.000159512163487415 12 1.3930283044039 1.51673457153469 1 10.1419305983976 16 600 133 651 333 133 12 172 835 171 90 77 M17898 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 55/65 Gene Ontology MF GO:0016627 0.00040597639412631 0.00260501519564382 110 265 172 3.69137572935225e-05 44 0.897518193593907 -0.992405991414304 -1 7.85314093681237 109 193 574 44 46 71 273 167 509 757 172 78 M19040 GO_ARYLSULFATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYLSULFATASE_ACTIVITY.html Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. 9/10 Gene Ontology MF GO:0004065 0.00575815747763356 0.0160222772559558 105 294.090909090909 174 0.000577313248780092 26 1.29959163747041 1.29959163747041 1 7.89990239902969 105 472 908 311 174 145 83 325 36 650 26 79 M18059 GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. 8/19 Gene Ontology MF GO:0015269 0.000176998308669356 0.00142893051893132 480 268.909090909091 176 1.77012408030477e-05 16 1.39857643612159 -1.22172627358625 -1 13.4896853965606 478 127 817 38 31 211 176 623 16 103 338 80 M18868 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. 6/29 Gene Ontology MF GO:0015347 0.00996916369055265 0.0237922069058475 180 277.363636363636 179 0.00100141710201614 27 1.79913101086094 -1.87450882091514 -1 9.89656701717898 246 270 888 175 179 277 178 631 27 132 48 81 M18228 GO_S100_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_S100_PROTEIN_BINDING.html Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. 17/20 Gene Ontology MF GO:0044548 0.0226816145749089 0.0443082703323802 180 239.545454545455 180 0.0020835354518033 41 1.04615090876776 -1.088706428115 -1 4.78493773440894 41 355 364 331 277 150 86 178 180 536 137 82 M17861 GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. 25/32 Gene Ontology MF GO:0035250 0.00737402964577956 0.0191181340071765 390 222.818181818182 181 0.000672623887382021 72 1.53298404658874 -1.31260653974825 -1 8.92353984854379 389 72 102 171 544 181 288 200 113 107 284 83 M18014 GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. 15/15 Gene Ontology MF GO:0010314 0.00203651023599335 0.00788100744707449 180 294.272727272727 181 0.0001853088956998 21 1.20458782251224 1.28334210368085 1 8.58130556900587 180 734 380 525 95 114 21 181 558 370 79 84 M18121 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 234/368 Gene Ontology MF GO:0001228 0.010792028332829 0.0253092238059238 60 311.272727272727 181 0.000985939520670537 33 1.15325135102272 1.12768621142443 1 6.22989001387265 57 632 159 643 556 33 84 315 600 181 164 85 M18092 GO_HEPARIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARIN_BINDING.html Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 151/236 Gene Ontology MF GO:0008201 5.38408042216151e-18 1.24372257751931e-15 10 277.090909090909 183 4.89461856560136e-19 3 1.68060456530435 1.62429724919922 1 85.05448126464 7 566 3 509 528 203 146 183 739 7 157 86 M18166 GO_NITRIC_OXIDE_SYNTHASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_SYNTHASE_BINDING.html Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. 32/45 Gene Ontology MF GO:0050998 0.0190036777004178 0.0386572471514107 115 362.636363636364 183 0.00174271319553197 56 1.15621229262161 1.16277125105944 1 5.52358050199606 115 721 183 635 892 127 72 240 807 141 56 87 M19095 GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a G-protein coupled receptor. 215/333 Gene Ontology MF GO:0001664 9.22829795963642e-08 2.18639674736001e-06 35 300.363636363636 187 8.38936213339461e-09 23 1.38168828691471 1.34742222829139 1 26.5378603976669 100 486 35 640 565 30 187 590 613 35 23 88 M18606 GO_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. 38/49 Gene Ontology MF GO:0008374 0.000451293405113299 0.00281753450219384 200 163.272727272727 188 4.10350915494237e-05 24 1.10779090697879 -1.16131883451955 -1 9.57053222053374 200 47 285 208 188 172 254 24 68 264 86 89 M18405 GO_NUCLEOSIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. 12/14 Gene Ontology MF GO:0019206 0.00160154708471825 0.00678820874440211 125 237.636363636364 189 0.000145701287463105 10 0.84359516761306 -0.84359516761306 -1 6.18811459414304 123 255 542 411 86 11 10 189 217 694 76 90 M19223 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. 78/152 Gene Ontology MF GO:0015081 1.03316993891829e-11 8.6786274869136e-10 355 245.181818181818 189 9.39245399021036e-13 8 1.65642482704438 1.53694454369019 1 50.9545437145967 189 179 8 181 750 353 337 106 353 21 220 91 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 70/85 Gene Ontology MF GO:0019199 2.48670442821743e-05 0.000310502012388231 40 256.545454545455 191 2.26066594216779e-06 37 1.36485208933274 1.40100949839488 1 16.2369402288766 142 308 58 544 593 191 377 83 449 40 37 92 M18649 GO_CARGO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARGO_RECEPTOR_ACTIVITY.html Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis. 54/78 Gene Ontology MF GO:0038024 1.53533793468421e-08 4.05329214756631e-07 110 179.363636363636 191 1.39576176854458e-09 22 1.70583935833561 1.77301623349949 1 37.0099771917954 107 191 31 262 420 243 226 37 389 22 45 93 M18446 GO_LIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 8/19 Gene Ontology MF GO:0055102 8.84489991731256e-05 0.000854124391762533 280 257.909090909091 192 8.84525198218004e-06 19 0.778800321210486 -0.753954705057122 -1 8.09216084601335 277 129 858 141 19 240 192 190 209 463 119 94 M18133 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY.html Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. 12/13 Gene Ontology MF GO:0034595 0.00162424845107082 0.00682184349449745 85 293 193 0.00014776807873848 84 0.759954435121923 -0.8890159801956 -1 5.56662953607271 143 552 633 336 84 105 312 193 85 693 87 95 M18613 GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 18/41 Gene Ontology MF GO:0015125 7.32180503701365e-06 0.0001073864738762 175 272.090909090909 193 6.65620854979703e-07 50 1.65959957219998 -1.73940619398753 -1 22.3477681191555 174 92 50 193 290 512 622 347 489 54 170 96 M18733 GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING.html Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. 44/54 Gene Ontology MF GO:0043548 0.0136892693622129 0.0297620820957286 85 258.090909090909 196 0.00125229080969716 54 1.101039614985 1.15344501300412 1 5.68353677025216 82 196 297 249 845 54 133 143 347 341 152 97 M18209 GO_GLUTATHIONE_PEROXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_PEROXIDASE_ACTIVITY.html Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. 11/17 Gene Ontology MF GO:0004602 0.000334976784522667 0.00222675215035212 395 247.272727272727 198 3.0457072699224e-05 30 1.24507960835601 -1.24583556067028 -1 11.1917845013251 391 118 264 30 44 130 198 522 84 541 398 98 M18593 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 87/117 Gene Ontology MF GO:0001191 0.0457328605408067 0.0781093588534296 140 297.454545454545 198 0.00424656014948163 99 1.12946737957362 1.16688921209805 1 4.22343084960436 139 176 365 111 614 99 170 584 473 343 198 99 M17868 GO_IMMUNOGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_BINDING.html Interacting selectively and non-covalently with an immunoglobulin. 4/24 Gene Ontology MF GO:0019865 0.000179382132193751 0.00142893051893132 55 215.090909090909 200 1.79396613916236e-05 3 1.42840866116781 -1.42840866116781 -1 13.7779436301438 52 271 800 314 204 25 3 120 200 303 74 100 M17913 GO_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLASE_ACTIVITY.html Catalysis of a ring closure reaction. 16/23 Gene Ontology MF GO:0009975 0.00999066696912211 0.0237922069058475 195 333.909090909091 203 0.000912393387985629 100 0.980485732344837 1.03334057808729 1 5.38236474977984 384 100 195 492 203 825 197 128 750 193 206 101 M18012 GO_STEROID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BINDING.html Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. 79/140 Gene Ontology MF GO:0005496 2.06080101175241e-07 4.47654649089024e-06 350 229.636363636364 205 1.87345564072126e-08 38 1.55239520406349 -1.58278519188643 -1 28.1787169144766 349 175 38 68 205 375 586 272 303 42 113 102 M18651 GO_LIPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 14/21 Gene Ontology MF GO:0060229 0.00206711290571001 0.0079232916062668 85 246.727272727273 205 0.000188096156098692 62 0.863892487679683 1.03076269251312 1 6.14056124512215 84 251 431 205 384 118 119 62 502 476 82 103 M18889 GO_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BINDING.html Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 243/308 Gene Ontology MF GO:0048037 0.00344893819704795 0.0117162459340893 185 210.545454545455 205 0.000314032453765819 94 1.16911431266046 -1.2000649513006 -1 7.64409318044798 182 155 276 166 113 94 335 234 270 205 286 104 M18214 GO_NEUROPEPTIDE_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_HORMONE_ACTIVITY.html The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. 9/29 Gene Ontology MF GO:0005184 0.00121860359058464 0.00562372684730844 120 280.636363636364 206 0.000121927235440233 17 2.75297618313046 2.56201292483285 1 21.0133170540767 117 474 835 596 201 163 206 47 219 212 17 105 M18468 GO_FIBRONECTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRONECTIN_BINDING.html Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. 29/46 Gene Ontology MF GO:0001968 4.87530970328619e-05 0.000556146440226721 95 234.272727272727 206 4.43219795084755e-06 60 1.77850084376878 1.6788905060616 1 19.6362711048237 95 433 60 406 206 264 190 96 380 197 250 106 M18574 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 270/414 Gene Ontology MF GO:0000982 0.0120718971305367 0.0272724521971049 615 327.181818181818 207 0.00110351379464029 38 1.16293122071354 1.1681140051052 1 6.15423349973257 54 631 176 730 612 38 73 345 611 207 122 107 M18362 GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. 19/29 Gene Ontology MF GO:0008106 0.00020275141161701 0.00154828350689353 75 245.909090909091 209 1.84336454131007e-05 32 1.61663923783964 -1.43732251816818 -1 15.4054561256997 71 531 209 410 32 124 217 182 459 353 117 108 M17962 GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. 10/15 Gene Ontology MF GO:0034483 0.00125580385514573 0.00568805275566007 70 188.909090909091 212 0.000114229206036622 6 1.63949820166261 1.24135310268973 1 12.4768822546011 66 256 212 268 352 64 6 225 182 364 83 109 M18027 GO_CARBOXY_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_LYASE_ACTIVITY.html Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. 29/37 Gene Ontology MF GO:0016831 0.00158755205451096 0.00675989907082085 215 377.636363636364 212 0.000144427164899766 42 0.946274082845058 -1.0084591205131 -1 6.95009275520011 212 784 524 761 81 42 116 164 729 688 53 110 M18674 GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate into, out of or within a cell, or between cells. 29/47 Gene Ontology MF GO:1901476 0.00577426225782821 0.0160222772559558 215 224.272727272727 212 0.000526315789473684 46 1.33695449148978 -1.3685240453215 -1 8.12771970372933 427 213 224 46 212 179 342 163 172 198 291 111 M18807 GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in). 7/12 Gene Ontology MF GO:0043225 5.91535014555388e-05 0.000628250980976067 50 237.545454545455 212 5.91550761260629e-06 7 1.32071089038101 -1.32071089038101 -1 14.3381198660154 49 133 884 251 476 212 67 7 226 280 28 112 M17963 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. 26/28 Gene Ontology MF GO:0052866 0.00335357835837919 0.0115255315885737 215 301.454545454545 213 0.000305336484959037 35 0.940294061793481 -1.21359255412548 -1 6.16599686068041 213 520 627 339 111 143 281 209 35 738 100 113 M18657 GO_NADH_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. 40/44 Gene Ontology MF GO:0003954 2.54010009692413e-06 4.04664222337568e-05 5 266.181818181818 213 2.30918457245951e-07 1 0.590370912626043 -0.590370912626043 -1 8.7840399614021 1 317 658 213 151 46 17 184 259 828 254 114 M19003 GO_GLUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 15/16 Gene Ontology MF GO:0046527 0.000587760121593529 0.00345917421880523 215 285.818181818182 213 5.34470189559672e-05 54 0.807445422908639 -0.807445422908639 -1 6.72482521978183 169 244 599 433 54 263 126 101 213 729 213 115 M18337 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. 49/79 Gene Ontology MF GO:0015171 0.00295197821705629 0.0103712086409126 550 412.909090909091 214 0.000268722423884183 33 1.22176303667991 1.29081863898035 1 8.20917950983944 549 33 96 76 106 819 911 781 214 84 873 116 M18738 GO_TASTE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TASTE_RECEPTOR_ACTIVITY.html Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. 5/40 Gene Ontology MF GO:0008527 0.000405388808059482 0.00260501519564382 145 261.363636363636 214 4.05462780090794e-05 9 1.23531459400672 1.06129268879709 1 10.8179376126892 141 390 876 418 214 141 9 23 292 351 20 117 M18752 GO_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any chemokine receptor. 36/77 Gene Ontology MF GO:0042379 0.0281530525023837 0.052765558848281 50 348.909090909091 214 0.00259271929535274 48 1.35693056527505 1.36363599420975 1 5.86396723340984 48 510 132 685 594 167 186 459 704 139 214 118 M18873 GO_PEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 121/252 Gene Ontology MF GO:0030414 1.15767933305184e-10 6.6855981483744e-09 55 312.181818181818 214 1.05243575737524e-11 13 1.39189748091946 1.36236095808132 1 38.6216035267095 55 301 13 681 210 207 214 604 787 55 307 119 M18366 GO_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTININ_BINDING.html Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. 30/47 Gene Ontology MF GO:0042805 0.10677396287325 0.158107598870004 215 314 215 0.0102125494997051 143 1.25063469120627 1.07279505239963 1 3.37828303424159 166 212 254 147 395 405 158 895 143 215 464 120 M19214 GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. 24/25 Gene Ontology MF GO:0070273 0.0044340312745361 0.0138882877887164 125 339 215 0.000403908474892125 31 1.02941261910118 1.32810998498125 1 6.4695381863341 215 590 545 743 125 122 31 108 547 550 153 121 M18258 GO_GLYCOSAMINOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSAMINOGLYCAN_BINDING.html Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 186/306 Gene Ontology MF GO:0005539 3.44292352126305e-21 1.12210413033726e-18 5 300.636363636364 216 3.12993047387549e-22 1 1.64068879801247 1.61749993258084 1 100 9 634 1 597 527 259 152 216 733 4 175 122 M19153 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the platelet-derived growth factor receptor. 17/18 Gene Ontology MF GO:0005161 0.00125421671924753 0.00568805275566007 70 265.727272727273 216 0.00011408475614001 42 1.6060287153282 1.6060287153282 1 12.2216779879276 68 450 216 472 357 202 247 42 208 538 123 123 M17980 GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. 5/15 Gene Ontology MF GO:0047555 0.000659193255702286 0.00373677649244732 720 318.636363636364 217 6.5938887846435e-05 15 2.12649925857198 -2.0987820359949 -1 17.5081006386838 717 389 808 15 61 217 585 111 26 182 394 124 M18240 GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other. 13/17 Gene Ontology MF GO:0042887 0.0169402116543087 0.0354134741370616 250 260.818181818182 217 0.00155200696773711 78 1.29937152533713 -1.57381839046219 -1 6.37847540990804 247 115 223 409 217 78 110 175 744 449 102 125 M18690 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 181/280 Gene Ontology MF GO:0001077 0.0471053575573829 0.0799648500294021 135 311.181818181818 217 0.00437684222303658 115 1.18939127062344 1.1893144339721 1 4.40760412641468 135 562 151 553 479 115 122 313 628 148 217 126 M18378 GO_PALMITOYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. 29/36 Gene Ontology MF GO:0016409 0.000641153947499253 0.00367966613347398 435 249.272727272727 218 5.8303716143962e-05 31 0.957210063990386 -1.03365256533528 -1 7.88939850467936 218 64 538 118 56 384 432 372 31 435 94 127 M18393 GO_SH2_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH2_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. 34/52 Gene Ontology MF GO:0042169 0.00108602755416596 0.00528152347394394 320 219.727272727273 218 9.87785492061897e-05 54 1.19497746188671 -1.10660949321534 -1 9.21812361076466 317 54 270 86 70 218 221 205 101 283 592 128 M18560 GO_MYOSIN_HEAVY_CHAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_HEAVY_CHAIN_BINDING.html Interacting selectively and non-covalently with a heavy chain of a myosin complex. 19/27 Gene Ontology MF GO:0032036 0.0201367561748379 0.0404489806859301 260 267.727272727273 218 0.00184758784729587 90 1.16214177757479 -1.18844800840302 -1 5.47436679485174 258 90 296 218 640 112 201 169 365 457 139 129 M18136 GO_GLUCOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. 7/12 Gene Ontology MF GO:0015926 0.00123356984156809 0.00564266600796494 50 397.363636363636 219 0.000123425513957452 32 1.29440078065891 1.29440078065891 1 9.86081607248573 219 693 828 668 844 213 49 48 32 603 174 130 M19110 GO_NUCLEOTIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. 25/28 Gene Ontology MF GO:0019201 0.00723160848452454 0.0189291961464608 140 303 219 0.000659589948907973 136 1.06035678633965 -1.13823523425337 -1 6.18041755854723 475 219 371 137 152 195 592 153 615 288 136 131 M18656 GO_ION_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. 29/51 Gene Ontology MF GO:0022839 0.0135999098070779 0.0296375392965565 530 301.272727272727 220 0.00124406511726644 58 1.53874512105186 -1.45663780773259 -1 7.96212426087784 526 431 116 138 220 289 700 649 75 112 58 132 M18897 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 113/180 Gene Ontology MF GO:0016614 0.0192721195338888 0.0390514001081431 305 233.818181818182 220 0.00176754948116252 6 1.35650039016965 -1.16351933445161 -1 6.46432349636735 304 6 124 63 241 220 430 528 86 136 434 133 M18102 GO_ARYL_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYL_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. 2/15 Gene Ontology MF GO:0004062 8.88010789768359e-05 0.000854124391762533 190 259.5 222 9.86717598866351e-06 2 1.40617376919695 -1.40617376919695 -1 14.6304597685416 186 480 823 NA 258 306 112 9 17 402 2 134 M19200 GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a calcium channel. 35/62 Gene Ontology MF GO:0005246 0.00957109599047597 0.023135301227543 815 382.545454545455 222 0.000873908219595864 140 1.44506220432377 -1.5914774120834 -1 8.0038273114468 813 208 152 140 170 774 792 357 397 222 183 135 M17950 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of hydrogen ions from one side of a membrane to the other. 80/114 Gene Ontology MF GO:0015078 0.00546125166197179 0.0160222772559558 275 251.272727272727 223 0.000497714173244692 17 0.78307777338295 -0.637969818121745 -1 4.75049640623897 21 17 617 274 137 77 69 223 271 759 299 136 M18507 GO_PHOSPHOTYROSINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTYROSINE_BINDING.html Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. 19/23 Gene Ontology MF GO:0001784 0.00078483218866657 0.00421353535544226 225 210.090909090909 224 7.13738464645266e-05 3 1.1774576467231 -1.19113680645448 -1 9.47497968988004 224 232 387 55 362 188 269 46 89 456 3 137 M18361 GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. 11/19 Gene Ontology MF GO:0015114 0.0001695848904563 0.00139907534626448 230 203.454545454545 226 1.54179967414431e-05 13 1.59463958507442 1.81109589448379 1 15.4338389159794 226 380 267 282 336 153 68 13 144 272 97 138 M18192 GO_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASE_BINDING.html Interacting selectively and non-covalently with any protease or peptidase. 121/192 Gene Ontology MF GO:0002020 0.020450572404719 0.0407248467714663 230 328.818181818182 227 0.00187665331661601 108 1.34300906964241 1.5314172385681 1 6.3166690793875 227 637 206 610 455 223 363 171 421 196 108 139 M18515 GO_ELECTRON_CARRIER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_CARRIER_ACTIVITY.html Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 114/160 Gene Ontology MF GO:0009055 0.00848214071634158 0.0212398320376683 40 246 227 0.000774092853196879 38 0.989782190403712 -0.953794674014366 -1 5.59930299112433 38 170 405 265 162 75 138 227 294 606 326 140 M18420 GO_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. 51/149 Gene Ontology MF GO:0004497 1.45733699842918e-05 0.000189659068527967 200 283 228 1.32486059299687e-06 55 1.58213274956745 -1.6892876710962 -1 19.976098760435 199 418 55 593 338 125 301 228 720 71 65 141 M18462 GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. 22/35 Gene Ontology MF GO:0004033 0.000842178072844858 0.00440957011923595 110 267.090909090909 228 7.65909671287154e-05 64 1.62410902442775 -1.49472840658268 -1 12.9694386303707 110 440 169 223 64 216 321 546 355 228 266 142 M18909 GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a potassium channel. 40/60 Gene Ontology MF GO:0015459 0.00207416888947412 0.0079232916062668 230 286.181818181818 228 0.000188738819031335 59 1.34621835433006 -1.44599309880558 -1 9.58248788984688 228 579 188 250 681 160 388 63 414 138 59 143 M17959 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. 94/142 Gene Ontology MF GO:0016616 0.00577426225782821 0.0160222772559558 205 220.454545454545 230 0.000526315789473684 11 1.22354195278788 -1.1114008000471 -1 7.43619493763919 201 11 234 16 198 230 344 348 157 270 416 144 M18295 GO_CATION_SUGAR_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_SUGAR_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). 13/16 Gene Ontology MF GO:0005402 0.00365261254607405 0.0121841660381676 230 256.181818181818 230 0.000332608275761095 20 1.09478048253622 -1.00396779386807 -1 7.09329085122788 230 254 443 329 223 128 20 211 115 578 287 145 M18989 GO_ALPHA_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_ACTININ_BINDING.html Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. 17/31 Gene Ontology MF GO:0051393 0.00577426225782821 0.0160222772559558 335 288 230 0.000526315789473684 53 1.14580369918764 1.20076812440824 1 6.96219154919148 333 99 286 53 219 703 526 112 199 408 230 146 M17984 GO_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. 44/47 Gene Ontology MF GO:0033558 0.00562076106258951 0.0160222772559558 140 393.909090909091 231 0.000512288461148447 19 0.744537002596902 -0.736655300283101 -1 4.51549683910286 136 774 750 539 717 19 97 191 231 786 93 147 M18019 GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 20/21 Gene Ontology MF GO:0030676 0.0110045107069767 0.0254919806690057 325 345.454545454545 231 0.00100544949172291 63 1.06483042546809 0.907263955497109 1 5.73907696777845 659 77 231 75 181 321 324 882 63 140 847 148 M18713 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. 38/43 Gene Ontology MF GO:0044390 0.0024827593507363 0.00903177023653679 200 347.272727272727 232 0.000225960513310645 70 0.976311902592472 1.07200935574692 1 6.75423043244849 197 204 530 379 874 360 148 70 193 633 232 149 M18586 GO_ALKALI_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALI_METAL_ION_BINDING.html Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. 19/43 Gene Ontology MF GO:0031420 0.0142377396799199 0.0306659008490581 365 278.909090909091 235 0.0013027932404199 75 1.61478227991499 -1.51306586102658 -1 8.27552829446262 362 529 131 293 744 103 75 149 235 260 187 150 M18537 GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. 245/394 Gene Ontology MF GO:0022804 1.94796290388706e-07 4.39004322729669e-06 525 279.727272727273 237 1.77087552397005e-08 26 1.25518854182594 -1.23122842887093 -1 22.8153720646626 524 153 37 69 536 166 552 449 328 26 237 151 M18931 GO_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVITY.html Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. 20/35 Gene Ontology MF GO:0004629 0.0180645383188562 0.037258110282641 330 239.272727272727 238 0.00165587244516715 52 1.39565879212144 1.7039505943036 1 6.74840548515632 327 348 145 354 311 274 174 218 238 191 52 152 M18725 GO_CCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a CCR chemokine receptor. 17/50 Gene Ontology MF GO:0048020 0.0222465322337071 0.043642878522177 240 280.727272727273 239 0.00204315705928523 89 1.25670754927082 1.41526947062808 1 5.78092423587484 89 239 213 326 265 279 175 176 777 311 238 153 M18288 GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING.html Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. 41/59 Gene Ontology MF GO:0050431 0.0106130070093407 0.025080354160181 105 384.181818181818 240 0.000969504874869757 103 1.19602629214041 1.28300358412709 1 6.4778870266525 103 714 194 738 569 456 166 130 770 240 146 154 M18439 GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. 67/148 Gene Ontology MF GO:0004867 2.28780296995623e-07 4.708825607359e-06 240 354.818181818182 240 2.07982109806117e-08 22 1.57230486687145 1.39774491847292 1 28.4231035309391 22 647 39 694 299 229 240 462 824 208 239 155 M18487 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. 57/74 Gene Ontology MF GO:0098811 0.163738529685739 0.225812539447199 240 351.454545454545 240 0.016124401047951 106 1.13518848840865 1.14270313916412 1 2.46737649517477 240 190 288 106 670 214 230 758 531 199 440 156 M18466 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. 29/46 Gene Ontology MF GO:0043027 0.00417370180232858 0.0133442922676526 640 362.545454545455 242 0.000380149180147597 21 1.12867796664512 -1.17473038111834 -1 7.16225158738182 639 211 242 133 525 799 846 276 186 110 21 157 M18315 GO_POLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 15/23 Gene Ontology MF GO:0030247 0.000435447217303093 0.00273709679447658 270 311.272727272727 243 3.95939481365764e-05 22 1.90057621660911 2.30305029004116 1 16.518201334613 269 243 87 116 394 735 539 22 783 125 111 158 M18512 GO_OMEGA_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OMEGA_PEPTIDASE_ACTIVITY.html Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). 14/15 Gene Ontology MF GO:0008242 4.84554443090438e-05 0.000556146440226721 715 328.727272727273 244 4.40513741662732e-06 9 1.36462667997909 -1.13261485617751 -1 15.0610765175599 714 105 208 22 9 639 896 54 268 244 457 159 M19010 GO_FRIZZLED_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRIZZLED_BINDING.html Interacting selectively and non-covalently with the frizzled (fz) receptor. 32/44 Gene Ontology MF GO:0005109 0.00154749450202065 0.00661983759197723 60 290.090909090909 244 0.000140780372090994 29 1.51791641492263 1.37646728021309 1 11.2101654893957 418 56 81 29 244 298 313 900 173 60 619 160 M19051 GO_METALLOAMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOAMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 12/13 Gene Ontology MF GO:0070006 0.00611522887079661 0.0167669776754186 565 408.909090909091 244 0.000557481227983558 50 1.2996906768696 1.2996906768696 1 7.81341101853612 127 897 562 721 140 190 50 244 794 565 208 161 M18671 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. 15/29 Gene Ontology MF GO:0016701 0.00530516710246469 0.0158639948306711 315 232.090909090909 246 0.000483454868132739 52 2.09424613324444 -2.32174437241759 -1 12.7759191352862 313 452 115 351 136 288 246 201 52 80 319 162 M19081 GO_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 566/838 Gene Ontology MF GO:0016491 0.0385418264219887 0.0673206949223395 285 282.363636363636 248 0.00392270761454899 87 1.14674715603529 -1.04824129904045 -1 4.53984218371658 87 282 912 207 281 92 248 320 230 126 321 163 M18094 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the epidermal growth factor receptor. 40/47 Gene Ontology MF GO:0005154 0.0261274135368119 0.0494707584180619 760 431 249 0.0024039058536166 42 1.20662797101918 1.24627605842654 1 5.32650442793439 759 42 226 104 249 617 727 740 131 225 921 164 M18351 GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. 25/37 Gene Ontology MF GO:0051119 0.00577426225782821 0.0160222772559558 505 276.818181818182 249 0.000526315789473684 48 1.35405893080247 -1.40026495343358 -1 8.23201278745876 503 220 241 48 252 249 438 426 87 201 380 165 M18808 GO_POTASSIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_BINDING.html Interacting selectively and non-covalently with potassium (K+) ions. 12/25 Gene Ontology MF GO:0030955 0.00185346816748902 0.00738191632224074 310 283.090909090909 249 0.000168639230169938 12 1.53496690615322 -1.65539055020861 -1 11.0896562062729 307 617 249 478 573 117 28 126 192 415 12 166 M19001 GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. 14/30 Gene Ontology MF GO:0005242 0.000244290682327535 0.00179146500373526 250 371.181818181818 249 2.22107102618634e-05 17 1.59959343253663 -1.7196444057871 -1 14.8985539445882 482 110 103 247 732 904 692 17 249 345 202 167 M18853 GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). 10/18 Gene Ontology MF GO:0016775 0.0312222700657405 0.0575835879056772 285 267.272727272727 250 0.00287948941074877 45 1.40752909305001 -1.62881080200494 -1 5.90212215063845 281 381 258 377 682 185 108 195 45 250 178 168 M18268 GO_ALCOHOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BINDING.html Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. 85/136 Gene Ontology MF GO:0043178 0.000108614900467599 0.000997632105522513 65 348.818181818182 251 9.87456938185088e-06 14 1.35713174468629 -1.31779291799453 -1 13.8084625807937 675 14 62 64 251 478 870 723 233 44 423 169 M18816 GO_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a growth factor receptor. 122/186 Gene Ontology MF GO:0070851 0.0176322313191493 0.0365828380376357 85 318.181818181818 251 0.00161592306817082 85 1.27463080343288 1.29085481423334 1 6.1954848760889 85 406 158 655 564 233 169 162 471 251 346 170 M19066 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. 52/67 Gene Ontology MF GO:0016655 3.07496746367557e-05 0.000368996095641068 5 272.727272727273 252 2.79546403974609e-06 3 0.788344681376093 -0.721026403121751 -1 9.16758119904538 3 313 446 209 114 51 25 252 566 742 279 171 M18344 GO_NUCLEOTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDASE_ACTIVITY.html Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. 13/15 Gene Ontology MF GO:0008252 0.0127346887663902 0.028348711995114 125 285.818181818182 253 0.00116445512831639 55 0.959684927710273 -0.932471876223707 -1 5.01962472048396 124 458 506 412 340 102 55 146 169 579 253 172 M17875 GO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_BINDING.html Interacting selectively and non-covalently with a SMAD signaling protein. 97/113 Gene Ontology MF GO:0046332 0.0106804783010607 0.0251113535627992 20 311.636363636364 254 0.000975698606026933 17 1.1615642871543 1.13662859033378 1 6.28841928184791 17 639 257 626 254 32 59 239 760 433 112 173 M18686 GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY.html Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. 23/25 Gene Ontology MF GO:0042813 0.00422219199998861 0.0134514304128153 690 408.363636363636 255 0.000384574270704048 42 1.4481523838336 1.56657684027788 1 9.17932678984429 686 73 170 42 122 906 658 790 70 255 720 174 M18935 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION.html Any protein binding that is involved in cell-cell adhesion. 13/15 Gene Ontology MF GO:0098632 0.0109339516038223 0.0254919806690057 420 303.909090909091 255 0.000998970385624103 121 1.35411014995773 -1.68772924851689 -1 7.30478882471017 416 374 352 226 255 164 207 133 772 323 121 175 M19099 GO_PURINERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_ACTIVITY.html Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 14/26 Gene Ontology MF GO:0035586 0.00333734170578714 0.0115255315885737 170 355.363636363636 255 0.000303855922070553 110 1.38247878905297 1.2118510164558 1 9.07704226970697 168 537 167 641 110 222 220 255 843 347 399 176 M19179 GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_.html Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. 13/15 Gene Ontology MF GO:0031078 0.0165392210405432 0.034944277476582 215 353.636363636364 255 0.00151498951509196 107 0.856515252035772 -0.857717300255458 -1 4.21312237257313 288 463 591 255 760 215 211 159 107 711 130 177 M18527 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS.html Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). 214/288 Gene Ontology MF GO:0016757 0.0286265287638865 0.0534361870259216 375 314.545454545455 257 0.00263690444985834 65 1.23879262773702 -1.12469812154377 -1 5.32824511776042 372 157 190 257 575 65 352 710 229 164 389 178 M18624 GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY.html Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 10/14 Gene Ontology MF GO:0004467 0.108586389667538 0.160277674205759 135 305.545454545455 258 0.0103952960739537 132 1.30193781488276 1.27134685056193 1 3.49168245454298 306 258 273 132 542 219 160 599 133 249 490 179 M18099 GO_WNT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_PROTEIN_BINDING.html Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. 30/33 Gene Ontology MF GO:0017147 0.000657264247399104 0.00373677649244732 810 416.727272727273 259 5.97691537744511e-05 20 1.47465767109227 -1.26861181077326 -1 12.1338574044592 808 55 73 20 259 722 816 755 95 127 854 180 M18100 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS.html Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). 153/208 Gene Ontology MF GO:0016758 0.102937546466424 0.154156066345179 160 324.818181818182 259 0.00982683386250348 156 1.27015001226332 -1.16093497858179 -1 3.47879647999552 393 167 181 259 464 156 398 651 227 156 521 181 M18432 GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 276/334 Gene Ontology MF GO:0005085 0.0916075536357998 0.14037376378023 250 337 260 0.00869640055867019 151 1.08949989660612 1.07733021313251 1 3.13107587353275 248 151 173 260 391 255 310 618 486 180 635 182 M19055 GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY.html Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. 19/40 Gene Ontology MF GO:0008329 0.0337408676865778 0.061130513220388 265 360.090909090909 262 0.00311543038293708 93 1.42782053365559 1.26408371701042 1 5.86167158787493 114 670 163 733 348 262 93 382 699 261 236 183 M18285 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 443/695 Gene Ontology MF GO:0000981 0.0237014292859959 0.0455868528378698 100 328.727272727273 263 0.0021782447862899 59 1.13078883630873 1.14001931835536 1 5.12657231741127 98 556 207 728 461 59 136 342 542 263 224 184 M18388 GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 215/261 Gene Ontology MF GO:0005088 0.000973167104262042 0.00496423456112558 180 336.363636363636 263 8.85088954753796e-05 76 1.13073467993584 1.1069722705133 1 8.82458000531415 178 293 76 263 677 199 242 579 515 108 570 185 M17979 GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 212/397 Gene Ontology MF GO:0015077 1.31816945822076e-11 1.01499048282999e-09 310 267.454545454545 264 1.19833587111696e-12 9 1.30969507844688 -1.27292235321955 -1 39.9809201026029 310 156 9 168 849 93 264 353 381 25 334 186 M18955 GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. 9/19 Gene Ontology MF GO:0015166 0.0083999984431171 0.0211727797593444 525 347.818181818182 264 0.000843192038740586 45 1.39488282217921 1.48831150276398 1 7.9074366247694 133 264 901 227 484 322 45 523 523 213 191 187 M18357 GO_IMMUNOGLOBULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. 9/121 Gene Ontology MF GO:0034987 0.00876769732649015 0.0216503584815815 180 347.363636363636 265 0.000880248327687383 99 1.09551377783788 0.94923788984144 1 6.16909517468813 176 265 848 431 418 208 179 125 736 336 99 188 M19124 GO_EPHRIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ephrin receptor. 38/43 Gene Ontology MF GO:0046875 0.0165644951674707 0.034944277476582 580 416.545454545455 265 0.00151732229118096 108 1.40220829170464 1.30090503616587 1 6.91279657299386 579 202 196 184 215 648 542 818 108 265 825 189 M18003 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 81/105 Gene Ontology MF GO:0016651 0.0011268653407064 0.00545143232886235 10 272.272727272727 267 0.000102494813486943 8 0.839033496045807 -0.734299978318616 -1 6.42593738666224 8 174 516 267 71 91 81 271 446 735 335 190 M18371 GO_TRANSCRIPTION_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COFACTOR_BINDING.html Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. 29/34 Gene Ontology MF GO:0001221 0.0096397088448096 0.023135301227543 40 316.454545454545 267 0.000880200723184146 40 0.993339237709396 0.914449490823096 1 5.49426536189651 40 435 490 438 752 113 58 124 267 529 235 191 M18859 GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. 12/39 Gene Ontology MF GO:0005251 0.000992540565281614 0.00501151629683176 475 403.181818181818 267 9.02716943418035e-05 36 2.22351025181171 -2.28156934358677 -1 17.3452754538976 474 812 83 846 676 210 267 36 805 185 41 192 M18590 GO_NEUROPILIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPILIN_BINDING.html Interacting selectively and non-covalently with a member of the neuropilin family. 15/15 Gene Ontology MF GO:0038191 0.00212683455342527 0.00802120460148957 265 362 268 0.000193535767538187 64 1.54201656691923 -1.41352575127372 -1 10.9517885996971 334 606 156 594 264 221 261 64 790 268 424 193 M18124 GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY.html Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 6/26 Gene Ontology MF GO:0015464 0.00793945715456644 0.0201540066231302 120 316.090909090909 269 0.000796796635375248 21 1.22686519541018 1.34359418805497 1 7.0412808111075 118 269 827 280 545 429 105 117 21 584 182 194 M18845 GO_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. 75/104 Gene Ontology MF GO:0008238 0.141127241120142 0.199390781032127 270 362.090909090909 269 0.0137352079285599 181 1.21877939291074 -1.00342287452896 -1 2.87455844478648 267 181 233 269 566 733 541 319 391 236 247 195 M18987 GO_2_IRON_2_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_IRON_2_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. 24/29 Gene Ontology MF GO:0051537 0.00904059274530074 0.0220992267107351 80 309 269 0.000825268995250924 78 1.25193533617401 -1.06175674515105 -1 7.01551202711948 78 586 447 364 901 126 96 121 140 269 271 196 M17949 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 30/38 Gene Ontology MF GO:0001106 0.0371969172487856 0.0655915105684692 160 314.909090909091 270 0.00344010298727969 137 1.10297157732879 1.27093732932275 1 4.40794794622555 156 514 452 393 270 186 137 284 210 621 241 197 M18162 GO_SEROTONIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_ACTIVITY.html Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. 3/14 Gene Ontology MF GO:0099589 0.00282123497837684 0.0101026978171433 275 343.636363636364 271 0.000282482310630172 47 1.5442804018578 -1.47426023309742 -1 10.4423698862857 424 272 831 129 271 880 477 78 47 253 118 198 M18475 GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES.html Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance. 99/130 Gene Ontology MF GO:0043492 0.00865926974182393 0.0215431669859392 180 303.363636363636 271 0.000790321991476359 12 1.03477486940201 -0.990425815931995 -1 5.83329048437409 177 12 271 428 666 135 454 138 665 357 34 199 M17884 GO_NEUROTRANSMITTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BINDING.html Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 11/32 Gene Ontology MF GO:0042165 0.00772225114907146 0.0198204446159501 690 363.454545454545 272 0.000704499189812551 55 1.18941055543959 -1.08077680754733 -1 6.85485832763573 690 111 256 95 159 272 291 807 55 388 874 200 M18263 GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). 27/47 Gene Ontology MF GO:0016303 0.0846051755066063 0.130727729378101 240 398.727272727273 273 0.00800414077326709 69 1.13484926853254 -1.22318630739357 -1 3.38158417496771 884 69 253 236 809 386 407 273 240 238 591 201 M17991 GO_FATTY_ACYL_COA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_BINDING.html Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. 31/35 Gene Ontology MF GO:0000062 0.00416053913153569 0.0133442922676526 510 347.909090909091 274 0.000378948022513601 74 1.00054325295411 -0.928436102539377 -1 6.34639257723145 508 582 539 239 131 251 505 90 74 634 274 202 M18633 GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. 20/21 Gene Ontology MF GO:0052745 0.00577426225782821 0.0160222772559558 460 337.363636363636 275 0.000526315789473684 37 0.666549813976174 -0.697146272862183 -1 4.03997558734139 457 79 567 37 237 275 529 613 54 771 92 203 M18748 GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any N-glycosyl bond. 21/26 Gene Ontology MF GO:0016799 0.0565726500401235 0.0940164184120037 120 354.545454545455 279 0.00528018489478271 116 0.901247587474451 -1.01291837034615 -1 3.11873280774024 116 231 496 505 866 120 161 279 385 598 143 204 M18801 GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-specific protease. 13/13 Gene Ontology MF GO:1990381 0.00791423478583921 0.0201453249094089 160 323.545454545455 279 0.000722077228068065 39 0.598519026980054 -0.598519026980054 -1 3.4230013017878 158 464 683 345 279 52 39 203 323 908 105 205 M18352 GO_INTERLEUKIN_1_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the interleukin-1 receptor. 27/51 Gene Ontology MF GO:0005149 0.000794361080364078 0.00421833125434717 60 332.909090909091 280 7.22407316317462e-05 33 1.14812607425027 1.25179005210465 1 9.23641815524388 60 585 280 564 419 239 167 33 753 397 165 206 M18812 GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. 20/35 Gene Ontology MF GO:0005217 0.0117432298087444 0.0267682257886261 280 351.545454545455 280 0.00107330778744383 136 1.09720395134149 1.2399656377585 1 5.83523527270059 280 229 247 340 747 280 443 136 752 190 223 207 M17933 GO_STEROID_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_DEHYDROGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. 23/53 Gene Ontology MF GO:0016229 0.00122334317782359 0.00562372684730844 215 329.454545454545 282 0.000111274906026673 78 1.47354995255867 -1.20740296024106 -1 11.2362499991805 211 589 282 145 78 287 376 226 642 532 256 208 M18701 GO_QUATERNARY_AMMONIUM_GROUP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_BINDING.html Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 22/56 Gene Ontology MF GO:0050997 0.125510588877388 0.181489490019885 580 347.454545454545 282 0.0121182564784808 74 1.3469894672246 1.27888657218505 1 3.36640170675136 576 74 200 89 364 782 525 582 119 229 282 209 M18907 GO_PDZ_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PDZ_DOMAIN_BINDING.html Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. 106/141 Gene Ontology MF GO:0030165 0.00959008308283429 0.023135301227543 190 267.181818181818 282 0.000875649491356049 171 1.26907652331318 1.28871218583207 1 7.02613301345707 311 303 290 187 171 282 196 420 187 241 351 210 M18984 GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON.html The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 105/144 Gene Ontology MF GO:0005200 0.0354057081605393 0.0634009192642215 240 319.363636363636 282 0.00327169892817413 95 1.40010554931105 -1.69722804263582 -1 5.67210967023075 239 304 179 360 826 134 282 393 605 96 95 211 M19137 GO_AMMONIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_BINDING.html Interacting selectively and non-covalently with ammonium ions (NH4+). 31/79 Gene Ontology MF GO:0070405 0.0431235227134059 0.0742013686912236 600 439.363636363636 282 0.00399934203608413 60 1.27519632683163 1.25363440942746 1 4.86803143371122 599 60 155 180 282 922 891 670 245 231 598 212 M18140 GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). 11/20 Gene Ontology MF GO:0015299 0.00264684906344622 0.00959093542989924 510 252.818181818182 284 0.000240912626967121 72 1.05962810822882 -0.769933184865011 -1 7.23880325294551 506 120 295 102 185 382 284 72 320 390 125 213 M19028 GO_GTP_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. 19/22 Gene Ontology MF GO:0030742 0.0141673474279113 0.0305855818303506 370 274.727272727273 284 0.00129631018512042 86 0.956948454134414 1.12777540679457 1 4.89804122642756 369 86 436 128 534 303 107 147 284 355 273 214 M17911 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS.html Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). 44/77 Gene Ontology MF GO:0016782 0.00887369184536707 0.0218066257051042 195 311.181818181818 285 0.000809971570516872 118 1.36872395202764 1.26488229835549 1 7.69913728451343 191 508 228 541 221 302 263 118 317 285 449 215 M19069 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC.html Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 16/18 Gene Ontology MF GO:0000983 0.00120228279209767 0.00561065302978915 400 284.545454545455 285 0.000109358212124747 77 1.51446588399942 -1.08812862905452 -1 11.5541189663434 400 454 214 389 77 458 208 129 224 292 285 216 M18554 GO_FILAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMIN_BINDING.html Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. 11/17 Gene Ontology MF GO:0031005 0.00945563809487922 0.0229921305254431 170 294.363636363636 286 0.000863320438939241 106 1.22828281486592 1.16504807763829 1 6.81074889387279 192 545 187 307 168 604 354 166 286 106 323 217 M18080 GO_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. 20/27 Gene Ontology MF GO:0016289 0.104219120267868 0.155428526688165 835 446 289 0.00995551698641981 75 1.03122239483919 1.05646650824392 1 2.80733263070966 831 75 239 163 495 644 821 289 274 188 887 218 M18234 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells. 34/39 Gene Ontology MF GO:1901505 0.00514541970138823 0.015588091160927 315 253.727272727273 289 0.000468863045554781 59 1.29915872780172 -1.13857189685575 -1 7.94990880122015 153 59 390 313 317 175 314 97 289 429 255 219 M19226 GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. 38/59 Gene Ontology MF GO:0005544 0.0190357656427401 0.0386572471514107 490 361.818181818182 289 0.00174568165244895 44 1.08301815790757 -1.11939009287858 -1 5.172373665572 487 44 289 119 225 673 737 700 71 266 369 220 M18781 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. 16/20 Gene Ontology MF GO:0019198 0.00871339104282083 0.0215849150765856 210 353.727272727273 291 0.000795281287152943 44 1.46309751020967 1.7991485277167 1 8.25372007011622 210 535 203 561 382 168 44 264 875 291 358 221 M17907 GO_PEPTIDASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_REGULATOR_ACTIVITY.html Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 161/301 Gene Ontology MF GO:0061134 2.32816695225634e-09 8.86269520528547e-08 100 321.636363636364 292 2.11651541338194e-10 20 1.32661800543768 1.35291359634417 1 31.7518242105117 97 402 20 491 292 285 252 588 732 48 331 222 M18065 GO_PEPTIDE_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for peptide hormones. 18/24 Gene Ontology MF GO:0051428 0.0122002703525786 0.0274283450262351 670 359.909090909091 292 0.00111531435294606 94 1.27724743029534 -1.40351793295301 -1 6.75084178360179 666 94 292 153 191 489 231 258 454 438 693 223 M18565 GO_INTEGRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_BINDING.html Interacting selectively and non-covalently with an integrin. 137/163 Gene Ontology MF GO:0005178 2.58812214172789e-09 9.19778791906372e-08 15 277.727272727273 292 2.35283831342963e-10 14 1.29358200271545 1.39365746787978 1 30.8897102392231 14 404 22 493 319 383 292 119 718 31 260 224 M18067 GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 71/145 Gene Ontology MF GO:0015103 0.0324979820618227 0.0593441411563719 185 399.181818181818 293 0.00299892769264848 150 1.39114696466045 -1.30478708822743 -1 5.77134839158946 718 182 150 185 293 794 631 198 216 298 726 225 M18302 GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. 24/37 Gene Ontology MF GO:0015175 0.00893951414875044 0.021910108948131 70 330 293 0.000816004282457064 69 1.36991827952032 1.36178202927718 1 7.69631022638292 293 70 107 85 718 685 460 472 174 69 497 226 M18135 GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. 30/45 Gene Ontology MF GO:0015662 0.000977803777191401 0.00496423456112558 585 330.272727272727 294 8.89307853468509e-05 35 1.29051242683459 -1.32474053054522 -1 10.0749602645192 196 658 236 585 585 170 350 35 458 294 66 227 M18376 GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS.html Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). 19/20 Gene Ontology MF GO:0016780 0.00577426225782821 0.0160222772559558 330 324.818181818182 294 0.000526315789473684 8 0.922390221152297 -0.883332498684517 -1 5.59994399783515 326 353 620 51 675 182 294 233 8 568 263 228 M18450 GO_LAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMIN_BINDING.html Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. 27/29 Gene Ontology MF GO:0005521 0.00104345486697144 0.00514764412153346 450 348.909090909091 295 9.490455491429e-05 35 0.765244873710599 -0.820754460786854 -1 5.92339784112766 447 215 631 295 478 276 427 39 250 745 35 229 M18024 GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING.html A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors. 35/51 Gene Ontology MF GO:0098531 0.000788897853345791 0.00421353535544226 875 429 296 7.17437169340445e-05 53 1.17396444865736 -1.18758247173898 -1 9.44679800623589 873 53 246 296 63 687 894 778 134 220 475 230 M18434 GO_BETA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. 39/46 Gene Ontology MF GO:0048487 0.0189500861598437 0.0386531558757077 260 407.636363636364 296 0.00173775563663633 55 0.894156667636741 -0.946272686990733 -1 4.26630066701015 256 779 635 850 250 108 336 296 277 642 55 231 M18961 GO_CHEMOREPELLENT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOREPELLENT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. 34/41 Gene Ontology MF GO:0045499 0.000193843214778511 0.00149259275379453 70 353.636363636364 297 1.76236633198501e-05 66 1.55978423793723 1.57969037774192 1 14.9470944204529 297 326 66 169 262 853 725 221 494 68 409 232 M19169 GO_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. 82/97 Gene Ontology MF GO:0008080 0.0202916650424724 0.0404956771041998 135 408.272727272727 297 0.00186193435508139 134 0.83824436059562 0.899642307105905 1 3.940431641011 134 642 754 675 229 234 134 297 195 806 391 233 M18054 GO_NUCLEOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_BINDING.html Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. 64/80 Gene Ontology MF GO:0031491 0.0270864957911159 0.0510773920632471 300 332.181818181818 298 0.00249325908359866 63 0.984097934971532 -1.01460761786754 -1 4.29330681368504 184 187 566 397 586 63 298 249 300 674 150 234 M18298 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 131/168 Gene Ontology MF GO:0001076 0.0890014482505131 0.13706223030579 525 347.727272727273 298 0.00843819429269498 149 1.05481949666991 1.11277889803236 1 3.06778126086871 187 298 525 206 387 149 234 571 496 523 249 235 M18578 GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a negatively charged ion from one side of a membrane to the other. 195/337 Gene Ontology MF GO:0008509 3.50529161244043e-07 6.89125414871268e-06 700 357.545454545455 299 3.18662924631246e-08 32 1.32001209343456 -1.3020452714719 -1 23.1169596483552 699 159 40 61 278 340 740 881 299 32 404 236 M18924 GO_SH3_SH2_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_SH2_ADAPTOR_ACTIVITY.html Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). 45/69 Gene Ontology MF GO:0005070 0.00577426225782821 0.0160222772559558 630 308.636363636364 299 0.000526315789473684 10 1.33310374843603 -1.32494226352635 -1 8.10424007599152 627 37 168 10 331 313 299 596 28 143 843 237 M17953 GO_MAGNESIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_BINDING.html Interacting selectively and non-covalently with magnesium (Mg) ions. 210/271 Gene Ontology MF GO:0000287 0.00577426225782821 0.0160222772559558 225 350.909090909091 300 0.000526315789473684 33 0.902210934560671 -0.898521584026891 -1 5.47690225483337 225 158 670 33 789 43 300 370 432 700 140 238 M18871 GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. 9/12 Gene Ontology MF GO:0010857 0.00209229778347305 0.0079232916062668 80 336.454545454545 303 0.000209427036739578 22 0.967416292819553 0.967416292819553 1 6.87931769156523 80 475 891 573 100 62 22 303 517 649 29 239 M18176 GO_INSULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin receptor. 35/46 Gene Ontology MF GO:0005158 0.00378582592936611 0.0123787609673877 225 351.454545454545 304 0.000344759675503562 86 1.15123460349478 1.07964216681622 1 7.43341272370956 223 209 263 471 662 304 353 86 747 221 327 240 M18591 GO_PEPTIDE_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen peptide. 30/62 Gene Ontology MF GO:0042605 0.0302360690373688 0.0562135368018688 70 446.909090909091 304 0.00278725448646933 69 0.942820411017037 -0.898864551147162 -1 3.97895899676984 69 869 503 769 304 95 227 192 892 704 292 241 M18898 GO_CULLIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). 15/16 Gene Ontology MF GO:0097602 0.0117617961798509 0.0267682257886261 160 347.636363636364 304 0.00107501387718003 54 0.640528085718021 -0.640528085718021 -1 3.39640719761884 160 455 663 464 194 155 54 260 387 728 304 242 M19007 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. 9/10 Gene Ontology MF GO:0046933 0.00294252088914194 0.0103712086409126 70 382.636363636364 305 0.000294642445891878 70 0.445073059057792 -0.453570497425689 -1 2.97507707738037 75 468 904 434 108 70 70 257 601 917 305 243 M18206 GO_CATECHOLAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BINDING.html Interacting selectively and non-covalently with catecholamine. 5/17 Gene Ontology MF GO:1901338 0.000191984889943788 0.00149070620426941 340 343.636363636364 306 1.92001478149876e-05 33 1.91850697206692 -2.47933247650535 -1 18.3938205262661 338 478 834 230 33 292 370 306 281 349 269 244 M18290 GO_SH3_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. 125/157 Gene Ontology MF GO:0017124 0.00917457616092707 0.0223675682656903 310 285.727272727273 306 0.000837551038696568 139 0.99766346445596 1.00858828716124 1 5.56795100877988 172 297 392 308 167 196 139 329 415 306 422 245 M18978 GO_FATTY_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. 11/20 Gene Ontology MF GO:0015645 0.136485508809656 0.193721367342737 355 353.363636363636 306 0.0132518291441736 138 1.30193781488276 1.27134685056193 1 3.12774287365437 353 467 306 225 555 252 189 602 138 276 524 246 M18305 GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 8/20 Gene Ontology MF GO:0005328 0.00194780959011571 0.00769135068917486 315 347.818181818182 307 0.000194951898221018 66 1.28429759001693 1.5489706979881 1 9.19689740994794 314 261 842 286 623 365 172 66 501 307 89 247 M18680 GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. 104/148 Gene Ontology MF GO:0008194 0.000179389545666703 0.00142893051893132 805 387.181818181818 308 1.63094704442133e-05 58 1.43848456746188 -1.36280261956953 -1 13.8753035469981 804 302 65 113 385 308 674 764 242 58 544 248 M18509 GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 17/22 Gene Ontology MF GO:0099604 0.00241826622907486 0.00897380721150672 465 404.909090909091 309 0.000220084410366229 69 1.05830852435516 -0.925889927641071 -1 7.33358017235028 461 234 309 252 733 543 673 69 683 214 283 249 M18878 GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. 143/254 Gene Ontology MF GO:0015291 2.01306966867234e-09 8.08728858197062e-08 865 362.272727272727 309 1.83006333683124e-10 3 1.37118136001715 -1.39569581349242 -1 33.0044145141446 861 165 19 3 512 309 711 703 188 13 501 250 M19121 GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 26/31 Gene Ontology MF GO:0008191 0.00504098502466488 0.015372508788087 15 384.727272727273 309 0.000459324809998261 11 1.1057195406532 1.11865510606956 1 6.78530213934329 11 588 122 619 261 232 309 470 888 490 242 251 M18217 GO_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 116/193 Gene Ontology MF GO:0016247 1.96418694893018e-05 0.000252070658446039 515 388.636363636364 310 1.78564044150096e-06 56 1.36557282277971 -1.51443584541792 -1 16.6654612367447 514 300 56 310 726 551 825 291 462 73 167 252 M18444 GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 10/15 Gene Ontology MF GO:0005247 0.000540142553793899 0.00319930589554848 300 387.090909090909 312 4.91159286218244e-05 18 1.19137337198089 1.49987731792879 1 10.0711525098923 312 620 504 297 863 578 297 25 76 668 18 253 M18793 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin-like growth factor receptor. 17/26 Gene Ontology MF GO:0005159 0.0283465424867743 0.0530206584165577 280 442 312 0.00261077355855461 85 1.21164979288103 1.07549375499748 1 5.22491980924083 279 807 375 803 887 107 98 214 895 312 85 254 M18982 GO_HISTONE_ACETYLTRANSFERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_ACETYLTRANSFERASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone acetyltransferase. 33/38 Gene Ontology MF GO:0035035 0.0131547137629223 0.028940370278429 30 304.909090909091 312 0.00120309418922274 30 1.0418023052797 1.02290627429626 1 5.41947355800497 30 429 335 569 312 68 57 161 858 403 132 255 M18412 GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. 61/83 Gene Ontology MF GO:0042625 0.0116501663531908 0.0266454299761097 360 309.090909090909 314 0.00106475649576721 77 1.03669153531068 -1.01613598892217 -1 5.51910616615231 250 314 358 481 769 109 223 135 326 358 77 256 M18522 GO_MANNOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 20/22 Gene Ontology MF GO:0000030 0.00865730418010841 0.0215431669859392 35 355.818181818182 314 0.000790141885845957 33 0.58294116407207 -0.58294116407207 -1 3.27559361297839 33 597 698 516 320 48 43 185 314 898 262 257 M19198 GO_OXIDIZED_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDIZED_NAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. 17/18 Gene Ontology MF GO:0070403 0.00577426225782821 0.0160222772559558 610 386.909090909091 314 0.000526315789473684 39 1.45031991056966 -1.34649613643513 -1 8.8189571613263 607 89 279 39 749 281 423 478 80 314 917 258 M18235 GO_ANTIOXIDANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIOXIDANT_ACTIVITY.html Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. 50/82 Gene Ontology MF GO:0016209 9.43584690905601e-05 0.000886888199434438 450 388.909090909091 315 8.57841058076783e-06 18 1.27278556924037 1.30866068984369 1 13.1696587664995 449 315 225 446 18 758 519 288 225 295 740 259 M18428 GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS.html Catalysis of the hydrolysis of any glycosyl bond. 93/134 Gene Ontology MF GO:0016798 0.0115200113093527 0.0264131276671015 345 286.818181818182 315 0.0010527982089695 13 1.0723540741433 -0.96177166580643 -1 5.72365057297333 344 13 388 83 186 79 416 705 315 500 126 260 M18433 GO_TELOMERASE_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_RNA_BINDING.html Interacting selectively and non-covalently with the telomerase RNA template. 15/16 Gene Ontology MF GO:0070034 0.00958750742741378 0.023135301227543 315 412.636363636364 315 0.000875413280895639 46 0.641760856909525 -0.641760856909525 -1 3.54105998614891 315 457 671 562 694 123 46 180 306 896 289 261 M19159 GO_CYTOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_ACTIVITY.html Functions to control the survival, growth, differentiation and effector function of tissues and cells. 103/239 Gene Ontology MF GO:0005125 6.62323776321776e-11 4.07991446214214e-09 60 348.636363636364 315 6.02112523947014e-12 10 1.68267737803631 1.71607838151554 1 47.9208788211467 56 569 12 591 796 176 315 513 604 10 193 262 M18191 GO_CATION_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). 17/28 Gene Ontology MF GO:0015491 0.00169407665552595 0.00701544965029157 425 380.727272727273 316 0.000154125687420511 87 1.12563713200435 1.18940902946892 1 8.21044827002829 421 98 243 199 87 801 575 785 316 406 257 263 M18202 GO_AMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. 35/43 Gene Ontology MF GO:0004177 0.0271528222608768 0.0510981828290227 365 277.818181818182 316 0.00249944137203378 82 1.31451871474711 1.23879466001241 1 5.74218548776001 88 207 346 363 577 238 82 316 334 361 144 264 M18697 GO_CHEMOATTRACTANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOATTRACTANT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. 22/29 Gene Ontology MF GO:0042056 0.0637453128900245 0.102968381342165 360 416 316 0.00597008397428923 165 2.1679982724409 2.39670305715106 1 7.24552611925972 359 882 165 848 548 295 258 248 405 316 252 265 M18706 GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a substance from one side of a membrane to the other. 647/1090 Gene Ontology MF GO:0022857 2.08324133234069e-07 4.47654649089024e-06 420 351.181818181818 317 2.08324152763597e-08 11 1.24555675538006 -1.20143039594893 -1 22.6042608604019 420 142 874 160 514 151 533 314 427 11 317 266 M18815 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. 27/49 Gene Ontology MF GO:0016684 2.38520897631427e-06 3.86654928791997e-05 680 362.636363636364 317 2.16837414757103e-07 3 1.32125249888089 -1.23272995471684 -1 19.7774786232911 676 66 138 23 3 557 708 633 191 317 677 267 M19195 GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 30/30 Gene Ontology MF GO:0017112 0.000347067967925089 0.00229064858830559 45 365.363636363636 318 3.1556612075223e-05 41 0.805748580530915 -1.03802938120141 -1 7.20053586957243 261 62 578 41 45 318 327 835 102 767 683 268 M17945 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). 11/29 Gene Ontology MF GO:0005104 0.000625291154510518 0.00361105641729824 695 395.363636363636 320 5.68608134132759e-05 55 1.69072807266977 -2.12942952749667 -1 14.0006422683383 692 546 144 599 55 320 155 293 506 271 768 269 M18163 GO_METALLOEXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOEXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 35/53 Gene Ontology MF GO:0008235 0.0681514161561497 0.10875977293313 100 407 320 0.00639626905660127 96 1.40452874104745 1.3672504622658 1 4.57207616756858 96 717 320 661 768 307 245 253 535 360 215 270 M18207 GO_CALCIUM_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. 64/103 Gene Ontology MF GO:0048306 0.00577426225782821 0.0160222772559558 225 323.181818181818 321 0.000526315789473684 35 1.13198655632355 -1.20645515715558 -1 6.87794251820703 321 184 222 35 224 459 494 419 525 382 290 271 M18454 GO_OLIGOPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOPEPTIDE_BINDING.html Interacting selectively and non-covalently with an oligopeptide. 13/20 Gene Ontology MF GO:1900750 0.000152541898043149 0.00129310746598046 325 381.545454545455 321 1.38684069001905e-05 25 0.916752080263093 -0.822543180743408 -1 8.96904562790733 851 106 321 219 25 316 480 283 606 321 669 272 M19155 GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. 45/52 Gene Ontology MF GO:0019205 0.00845723920580427 0.0212350245276173 205 334.363636363636 321 0.000771811507005421 37 0.919432507968575 -0.933736418554044 -1 5.19990979402526 204 321 580 322 615 37 205 116 603 571 104 273 M18911 GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. 22/74 Gene Ontology MF GO:0005230 0.0201977903074373 0.0404489806859301 885 482.909090909091 322 0.00185324012878346 125 1.47572813687804 -1.26341187225355 -1 6.95808898386498 885 223 125 220 322 789 820 560 272 230 866 274 M18383 GO_RECEPTOR_AGONIST_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_AGONIST_ACTIVITY.html Interacts with receptors such that the proportion of receptors in the active form is increased. 8/18 Gene Ontology MF GO:0048018 0.000261275970523153 0.00184289310506407 725 364.181818181818 323 2.61306694917135e-05 15 2.02925357831057 1.91682688928966 1 18.822193532435 722 128 851 21 41 453 323 810 15 65 577 275 M18269 GO_L_ASCORBIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_BINDING.html Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 18/21 Gene Ontology MF GO:0031418 0.0385272025718829 0.0673206949223395 235 355.090909090909 324 0.00356535680032262 44 1.46060907509829 -1.32390551557275 -1 5.78902693040179 618 446 277 231 274 324 466 471 44 235 520 276 M18708 GO_PEPTIDE_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_BINDING.html Interacting selectively and non-covalently with any peptide with hormonal activity in animals. 25/55 Gene Ontology MF GO:0017046 0.0050011619625694 0.0153015683887885 205 343.545454545455 324 0.000455687926868394 95 1.13563533982919 1.05652252165389 1 6.97728641102732 324 518 202 373 433 183 183 95 830 203 435 277 M17878 GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. 27/37 Gene Ontology MF GO:0008376 0.0751038511635118 0.118221394335749 580 386.818181818182 325 0.00707249131832479 133 1.35656614054081 -1.459596683169 -1 4.24820177670507 580 218 174 212 325 476 296 326 631 133 884 278 M18143 GO_LYSOPHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPASE_ACTIVITY.html Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. 19/23 Gene Ontology MF GO:0004622 0.00490319026477081 0.0151523337948101 325 356.818181818182 325 0.000446741121473876 94 1.40835345044602 1.71188106264818 1 8.67903931767959 325 233 172 546 848 490 385 94 417 170 245 279 M18730 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. 22/30 Gene Ontology MF GO:0016628 0.000251419629060068 0.00180086618024421 380 361.272727272727 325 2.28589423916285e-05 37 1.242881462967 -1.35913372237728 -1 11.5611455465753 376 225 325 194 37 390 685 155 706 609 272 280 M18204 GO_NADPH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADPH_BINDING.html Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. 12/16 Gene Ontology MF GO:0070402 0.00401621240849647 0.0130209833875464 130 362.363636363636 327 0.000365778454797173 87 0.675736266466241 -0.725060390340468 -1 4.30272874728613 129 615 587 327 175 157 367 87 453 878 211 281 M18253 GO_CAMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BINDING.html Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). 18/29 Gene Ontology MF GO:0030552 0.0442109025898964 0.075930992552164 175 376.818181818182 327 0.00410228976904083 106 1.38273003779725 1.31285462121941 1 5.23358858420193 171 448 259 656 619 147 106 499 717 327 196 282 M17899 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/30 Gene Ontology MF GO:0016675 0.00207991372283344 0.0079232916062668 80 289.636363636364 328 0.000189262064705421 52 0.721584035438856 -0.658872882653639 -1 5.12503359586113 76 342 605 357 96 84 52 368 93 785 328 283 M19063 GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. 14/20 Gene Ontology MF GO:0004198 0.00283181681238108 0.0101026978171433 630 389.272727272727 328 0.000257769861761264 76 1.33166836681816 -1.11067859859708 -1 9.0013541999639 630 364 328 276 222 719 863 76 96 247 461 284 M18374 GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY.html Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. 10/12 Gene Ontology MF GO:0031543 0.00373354604196509 0.0123548751921343 330 411.545454545455 329 0.00033999065566124 67 1.87455185078606 1.73401619414938 1 12.1243889548959 329 816 315 699 590 515 647 85 67 248 216 285 M18494 GO_PHOSPHATIDYLSERINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_BINDING.html Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. 43/62 Gene Ontology MF GO:0001786 0.0207261696711971 0.0410965252707857 150 427.727272727273 329 0.00190218595100195 63 1.07629041379251 1.10279880139953 1 5.04295047665284 150 857 255 725 513 162 249 548 854 329 63 286 M18875 GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. 12/13 Gene Ontology MF GO:0008484 0.000533000509522742 0.00317737077934847 240 299.363636363636 329 4.84663349953988e-05 33 0.987414778277998 1.13631215094637 1 8.35287581404013 236 376 369 216 53 332 329 558 33 695 96 287 M19171 GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any O-glycosyl bond. 69/105 Gene Ontology MF GO:0004553 0.00497087061492754 0.0153015683887885 525 356.727272727273 329 0.000452921626217356 23 1.09575052819997 -0.944095070060471 -1 6.73138396279753 525 23 334 174 129 329 621 780 291 443 275 288 M17863 GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate from one side of the membrane to the other. 31/38 Gene Ontology MF GO:1901677 0.173662227865441 0.237022006717382 310 367.454545454545 330 0.0171915695286384 196 1.14502448083549 -0.859840291409929 -1 2.4071401354337 308 330 403 324 758 241 210 455 196 378 439 289 M18335 GO_O_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. 18/20 Gene Ontology MF GO:0008171 0.0635899063553298 0.102902055117907 330 363.636363636364 330 0.00595508542423973 159 0.746584378903629 -0.730236216709392 -1 2.47991254405387 330 354 642 417 329 180 159 247 339 752 251 290 M18623 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other. 104/171 Gene Ontology MF GO:0005342 1.48948239671568e-08 4.04788745460379e-07 885 412.181818181818 330 1.35407491527276e-09 7 1.32001879849082 -1.37346559838969 -1 28.636304835853 881 7 30 164 330 653 897 693 276 14 589 291 M18129 GO_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. 23/41 Gene Ontology MF GO:0004180 0.0176609342464481 0.0365828380376357 160 338.727272727273 331 0.00161857500280204 51 1.07334606125149 1.40297628176071 1 5.21328634402013 159 343 303 365 309 379 606 236 644 331 51 292 M18449 GO_ATPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_BINDING.html Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. 92/113 Gene Ontology MF GO:0051117 0.00770113722613493 0.0198204446159501 375 330.727272727273 331 0.000702566185932092 27 1.07901807732511 -1.10827624125404 -1 6.21638800895132 375 172 472 246 481 27 289 331 593 496 156 293 M19185 GO_CYTOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a cytokine receptor. 202/377 Gene Ontology MF GO:0005126 0.00190012573408495 0.00753526256778753 95 358.272727272727 331 0.000172888077046238 78 1.29236675638625 1.34887531043512 1 9.29391727410482 91 633 84 682 543 331 372 229 654 78 244 294 M18113 GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. 33/37 Gene Ontology MF GO:0045309 0.0202244903429651 0.0404489806859301 595 381.818181818182 332 0.00185571288054733 109 1.04574442558796 -1.10093983932099 -1 4.92363705562147 595 328 465 152 332 616 735 170 109 582 116 295 M18174 GO_THIOLESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOLESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. 33/40 Gene Ontology MF GO:0016790 0.00777062946476372 0.019889367383495 160 343 332 0.000708928421141205 52 0.947391684941451 -0.917864805893666 -1 5.4502574543383 468 52 324 170 160 496 625 156 450 332 540 296 M19216 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. 11/14 Gene Ontology MF GO:0097153 0.00104735616325573 0.00514764412153346 820 380.818181818182 334 9.52595556104316e-05 19 0.890278344932202 1.09654689126882 1 6.89518713800292 816 121 442 99 69 538 328 334 19 544 879 297 M18568 GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. 26/31 Gene Ontology MF GO:0004683 0.00324362284211864 0.01126732145157 340 310.727272727273 336 0.000295310459090571 79 0.980802566683063 1.07384209935712 1 6.46545715066746 79 336 337 507 109 140 236 592 373 380 329 298 M18599 GO_CGMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BINDING.html Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). 7/19 Gene Ontology MF GO:0030553 0.0348707818571196 0.0626859969571567 340 401.454545454545 336 0.00354303676000788 100 1.60089034744362 1.80071409141472 1 6.51578734945678 336 132 870 144 605 466 100 480 310 279 694 299 M17957 GO_SULFUR_COMPOUND_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BINDING.html Interacting selectively and non-covalently with a sulfur compound. 231/344 Gene Ontology MF GO:1901681 9.56982151952728e-16 1.4737525140072e-13 340 317 337 8.69983774502477e-17 4 1.50112606501521 1.54648939120689 1 65.3960537294044 27 560 4 494 460 337 339 292 685 8 281 300 M18137 GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic hydroxy compound from one side of the membrane to the other. 51/92 Gene Ontology MF GO:1901618 3.79571544399809e-09 1.25258609651937e-07 20 341.454545454545 337 3.45065040958813e-10 17 1.52020500554704 -1.66441329448945 -1 35.6130302433085 530 35 24 17 568 632 803 566 337 18 226 301 M18418 GO_BINDING_BRIDGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_BRIDGING.html The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. 183/250 Gene Ontology MF GO:0060090 0.0384259804568125 0.0673206949223395 345 313.272727272727 337 0.00355582063530178 121 1.23737887905284 1.16080418038959 1 4.90056057318324 341 161 142 176 337 344 379 408 279 121 758 302 M18303 GO_E_BOX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_E_BOX_BINDING.html Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. 25/40 Gene Ontology MF GO:0070888 0.0169362863236758 0.0354134741370616 340 399.909090909091 338 0.00155164453427584 66 1.00299959652701 1.2474238360936 1 4.91808311603587 157 338 336 510 895 257 66 481 727 469 163 303 M18196 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 15/29 Gene Ontology MF GO:0008519 0.220180184233202 0.286544352438702 550 425.636363636364 339 0.0223547445331059 211 1.36856354429537 -1.60272534620947 -1 2.49879184120475 548 246 211 222 547 677 913 380 332 267 339 304 M18216 GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of cation from one side of the membrane to the other. 390/681 Gene Ontology MF GO:0008324 3.62681430750556e-10 1.86176467785285e-08 540 296.454545454545 341 3.29710391645769e-11 15 1.23038555798133 -1.19591932046199 -1 32.2785567433983 539 146 15 165 553 96 490 482 393 41 341 305 M18284 GO_STEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BINDING.html Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. 40/56 Gene Ontology MF GO:0032934 0.00577426225782821 0.0160222772559558 480 296.636363636364 341 0.000526315789473684 12 1.45073022677837 -1.26548201551043 -1 8.8214590347831 477 41 98 12 355 341 714 442 218 165 400 306 M18648 GO_CARBON_SULFUR_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_SULFUR_LYASE_ACTIVITY.html Catalysis of the elimination of hydrogen sulfide or substituted H2S. 10/13 Gene Ontology MF GO:0016846 0.00354352928682079 0.0119002142335058 485 348.727272727273 341 0.000322659066891788 80 0.73647595035854 -0.689080281012188 -1 4.78944289713967 481 124 511 139 341 502 719 80 142 669 128 307 M18237 GO_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_ACTIVITY.html The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. 44/137 Gene Ontology MF GO:0005179 8.15709015355254e-06 0.00011356886590428 110 424.545454545455 342 7.41556399846313e-07 52 1.82879977167506 1.83692818269237 1 24.4776564166192 108 856 52 842 876 342 123 65 809 405 192 308 M18531 GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. 64/69 Gene Ontology MF GO:0034212 0.00755004519738907 0.0194867088334847 65 398.181818181818 342 0.000688734628327633 63 0.644303349384362 0.656041081984444 1 3.71829310115259 63 575 785 678 158 171 71 275 435 827 342 309 M18901 GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING.html Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. 16/17 Gene Ontology MF GO:0043560 0.0573258981502045 0.0949210879847925 275 345.363636363636 344 0.00535241118967778 227 0.970112802684842 0.964851656054303 1 3.34518890713302 272 451 554 344 301 227 239 378 352 386 295 310 M18646 GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a carboxylic ester bond. 97/170 Gene Ontology MF GO:0052689 0.0043104731493603 0.013547201326561 795 355.545454545455 345 0.000392631084034482 9 1.2503641140055 -1.01322073175488 -1 7.90921823622179 793 9 94 60 635 345 455 465 236 149 670 311 M19143 GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. 17/30 Gene Ontology MF GO:0070001 8.96645735941187e-05 0.000854124391762533 490 376.090909090909 345 8.15165711163596e-06 7 1.56504148798054 -1.76992616596242 -1 16.2861317417196 489 356 345 98 17 834 867 643 7 313 168 312 M18619 GO_OXYGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_BINDING.html Interacting selectively and non-covalently with oxygen (O2). 18/94 Gene Ontology MF GO:0019825 0.00197652743202848 0.00777153764763539 380 311.090909090909 346 0.000179845947602728 91 1.85866044589463 -2.02024159046568 -1 13.2923454175467 234 447 110 498 91 377 378 619 346 115 207 313 M18663 GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 123/213 Gene Ontology MF GO:0008514 6.88939772639591e-07 1.27316069983796e-05 710 335.090909090909 346 6.26309080349306e-08 1 1.32585057580526 -1.38333477546653 -1 22.0188599393562 707 1 43 67 367 346 632 770 290 19 444 314 M18846 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. 22/25 Gene Ontology MF GO:0015215 0.00170830754471386 0.00701544965029157 90 345.272727272727 346 0.000155421408656964 55 0.898138360957484 -0.876218534406553 -1 6.54615804953944 90 346 570 613 838 87 113 55 399 511 176 315 M18932 GO_NUCLEOSOMAL_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOMAL_DNA_BINDING.html Interacting selectively and non-covalently with the DNA portion of a nucleosome. 46/61 Gene Ontology MF GO:0031492 0.00738655177550001 0.0191181340071765 130 316.090909090909 346 0.000673769954770837 26 1.11790919904034 -1.09507683647314 -1 6.5008086831332 130 507 483 484 400 26 129 346 275 587 110 316 M18959 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. 75/103 Gene Ontology MF GO:0016811 0.0135386602989002 0.0295738111493706 195 380.363636363636 346 0.00123842739168142 40 0.811460870762956 -0.810376422490975 -1 4.18995326415047 195 500 720 531 346 40 228 278 477 796 73 317 M18277 GO_GAMMA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. 35/46 Gene Ontology MF GO:0043015 0.0311024319918287 0.0574772943208995 150 401 347 0.00286827694266065 88 0.94385801355407 1.00905291873958 1 3.95241238317898 147 511 470 742 272 192 88 307 734 601 347 318 M18948 GO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger to initiate a change in cell activity. 729/2329 Gene Ontology MF GO:0004872 7.86537364302051e-22 7.26760524615095e-19 240 341.090909090909 347 7.86537364302055e-23 1 1.43747314998014 1.43516600517856 1 88.5319852012443 238 279 900 347 451 73 374 352 540 1 197 319 M18349 GO_SIGNALING_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_RECEPTOR_ACTIVITY.html Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 541/2031 Gene Ontology MF GO:0038023 3.09763210888224e-16 5.72442413721438e-14 235 354.090909090909 348 3.09763210888224e-17 2 1.40044945395767 1.41113358275773 1 62.9619231803027 231 396 847 348 405 131 369 340 561 2 265 320 M18431 GO_OXYGEN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORTER_ACTIVITY.html Enables the directed movement of oxygen into, out of or within a cell, or between cells. 4/17 Gene Ontology MF GO:0005344 0.000224379198246406 0.00168558031853397 280 383.636363636364 348 2.24401857177533e-05 35 2.45906097620581 -2.45906097620581 -1 23.1376214564971 276 479 857 602 35 299 375 263 382 304 348 321 M18852 GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with platelet-derived growth factor. 22/23 Gene Ontology MF GO:0048407 0.000303316816230275 0.00210725367065244 185 348.454545454545 349 2.75780584528745e-05 4 1.2480477015482 1.2480477015482 1 11.3200635626435 4 665 114 535 351 184 163 349 887 400 181 322 M18032 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 143/223 Gene Ontology MF GO:0001227 0.0334052543834884 0.0607607382880774 70 430 350 0.00308395803178809 67 1.12666752202194 1.1398154736777 1 4.63030508441545 67 702 350 884 898 119 92 220 656 484 258 323 M18458 GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. 13/19 Gene Ontology MF GO:0005229 0.00135680442478802 0.00603610093534639 410 381.181818181818 350 0.00012342199354704 8 1.45284320682653 -1.33481406656673 -1 10.9263687341795 407 738 278 758 480 224 461 350 167 322 8 324 M18573 GO_ACETYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_BINDING.html Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. 5/20 Gene Ontology MF GO:0042166 0.00203848569247923 0.00788100744707449 565 369.090909090909 350 0.000204035805098619 29 1.60938308437292 -1.68271391506174 -1 11.4731608839585 563 135 867 43 98 837 446 277 29 350 415 325 M17854 GO_COFACTOR_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORTER_ACTIVITY.html Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. 22/23 Gene Ontology MF GO:0051184 0.188286998232686 0.252943134936311 75 382.636363636364 351 0.0187857113779771 57 1.28848035505387 -1.28693716693762 -1 2.58820419976124 704 71 230 74 524 684 753 351 57 227 534 326 M18221 GO_PHOSPHOLIPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_BINDING.html Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. 23/29 Gene Ontology MF GO:0043274 0.0112543359263223 0.0259326842791067 285 442.909090909091 351 0.00102839312918323 53 0.872932883126692 0.884123867596173 1 4.67837153934628 284 226 351 566 712 198 53 873 870 425 314 327 M18991 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 43/50 Gene Ontology MF GO:0016667 0.0218845037311295 0.0431641144447131 355 372.363636363636 352 0.00200957097352974 135 0.809805713282222 -0.830670955102254 -1 3.72969850031925 352 199 649 135 233 519 560 294 148 619 388 328 M18309 GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. 12/15 Gene Ontology MF GO:0008239 0.00285983326019935 0.0101634074324007 490 366.909090909091 353 0.000260323418760742 105 1.83032030333465 1.63314561463241 1 12.364880888463 490 249 161 353 105 559 478 411 282 300 648 329 M18451 GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. 34/54 Gene Ontology MF GO:0052742 0.10488964096266 0.155868402764894 800 416.818181818182 353 0.0100229108308957 58 1.10073462288212 -1.22318630739357 -1 2.99361527888714 797 58 353 243 515 573 481 290 254 348 673 330 M18652 GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). 19/33 Gene Ontology MF GO:0015298 0.0105162890661549 0.0249155156336592 850 422.909090909091 354 0.000960627028633646 83 1.12260417043008 -1.0653428626825 -1 6.08964948804039 849 83 215 190 176 803 855 373 260 354 494 331 M18396 GO_CARBON_CARBON_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_CARBON_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 44/54 Gene Ontology MF GO:0016830 0.00661383805537634 0.0178168698634628 300 432.272727272727 356 0.000603073205413206 82 0.990661502963249 -1.01777953379089 -1 5.86108841724988 299 776 534 766 146 82 229 356 761 563 243 332 M18790 GO_SIALYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. 12/21 Gene Ontology MF GO:0008373 0.00121038041654743 0.00562005781351671 260 352.636363636364 356 0.000110095168040166 41 1.92090427942401 2.04034786130725 1 14.6566731636052 259 465 104 356 737 499 409 41 288 184 537 333 M18278 GO_PEPTIDASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 42/51 Gene Ontology MF GO:0016504 0.436966643390927 0.506596208899895 520 422.363636363636 357 0.0508796523135681 126 1.17334579509264 1.34372787612847 1 1.15269417026128 519 322 339 277 835 738 357 466 126 256 411 334 M19038 GO_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. 282/602 Gene Ontology MF GO:0004175 0.000133034856840919 0.00117070674020009 705 373.181818181818 357 1.20948092901492e-05 63 1.28382419908882 -1.18838440483735 -1 12.7583198309515 705 152 63 258 141 357 655 800 362 114 498 335 M18533 GO_GLUCOCORTICOID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glucocorticoid receptor. 17/19 Gene Ontology MF GO:0035259 0.000465414338423399 0.00288619361545786 205 300.090909090909 358 4.23193479013944e-05 49 0.952167785204217 0.943799534569542 1 8.18883505187724 202 358 458 482 49 253 142 188 401 407 361 336 M18927 GO_RETINOL_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. 13/32 Gene Ontology MF GO:0004745 0.000521965325285764 0.00315226118015716 830 419.909090909091 358 4.74626551223158e-05 51 2.08384108449659 -1.77305040747143 -1 17.6792465393211 828 248 75 123 51 831 766 358 361 90 888 337 M18035 GO_GUANYLATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYLATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + GMP = ADP + GDP. 14/16 Gene Ontology MF GO:0004385 0.0109840878107476 0.0254919806690057 675 435.545454545455 359 0.00100357411130303 150 1.15774009947833 -1.21176580517605 -1 6.24194587253192 671 370 359 150 180 674 838 224 754 344 227 338 M18158 GO_EXTRACELLULAR_MATRIX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_BINDING.html Interacting selectively and non-covalently with a component of the extracellular matrix. 75/88 Gene Ontology MF GO:0050840 4.77543217309193e-08 1.1925673859289e-06 15 366.090909090909 359 4.34130206977264e-09 12 1.59829347948111 1.68795859190951 1 32.1309700533544 12 646 33 665 466 359 338 362 748 49 349 339 M19009 GO_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. 91/156 Gene Ontology MF GO:0015293 1.64054808586083e-09 7.19243406665131e-08 20 375 359 1.49140735189473e-10 5 1.40118891123327 -1.42243211497644 -1 33.969588879835 757 8 17 5 359 601 850 518 149 16 845 340 M18965 GO_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. 71/315 Gene Ontology MF GO:0003823 0.0138607700897613 0.0299937975712867 335 423.272727272727 360 0.00126807962874504 132 1.1934467859599 -1.09365499001801 -1 6.1489240694896 331 846 269 603 202 132 453 360 769 525 166 341 M19189 GO_PROTEIN_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHANNEL_ACTIVITY.html Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel. 10/12 Gene Ontology MF GO:0015266 0.00725237192692684 0.0189299199448599 215 377.909090909091 362 0.000661490048256008 153 0.655498717883707 -0.553890267370901 -1 3.81135222641475 214 469 597 380 153 362 322 305 159 670 526 342 M18331 GO_MACROLIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROLIDE_BINDING.html Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. 16/18 Gene Ontology MF GO:0005527 0.187970617331119 0.252943134936311 365 402.636363636364 363 0.0187509495981286 144 1.0177665075768 -0.945454882736936 -1 2.03931631442094 144 362 498 517 741 283 218 410 264 629 363 343 M18540 GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of potassium ions (K+) from one side of a membrane to the other. 68/152 Gene Ontology MF GO:0015079 4.42463270931115e-09 1.40977952531155e-07 365 305.363636363636 363 4.02239338019088e-10 25 1.53530202820109 -1.61774849290149 -1 35.6992118852764 363 411 25 552 607 158 425 75 548 64 131 344 M18712 GO_FK506_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FK506_BINDING.html Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. 16/18 Gene Ontology MF GO:0005528 0.187970617331119 0.252943134936311 365 402.454545454545 364 0.0187509495981286 145 1.0177665075768 -0.945454882736936 -1 2.03931631442094 145 363 499 518 742 284 219 398 265 630 364 345 M19094 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 15/18 Gene Ontology MF GO:0004675 0.0495689186907583 0.0835797096172641 590 417.272727272727 365 0.00461112030925441 72 1.21223114494914 1.10984883372564 1 4.41365208306591 588 365 308 325 291 672 876 433 72 168 492 346 M18390 GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. 19/19 Gene Ontology MF GO:0071617 0.00376809036646841 0.0123787609673877 405 328.454545454545 366 0.000343141795498653 117 0.928957670006165 -1.00692753334137 -1 5.99350685353669 401 443 421 355 117 366 487 199 179 455 190 347 M18689 GO_CHOLESTEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 10/18 Gene Ontology MF GO:0017127 0.00246163223751724 0.00902598487089654 575 368 366 0.000224035539884795 100 1.50886037984121 -1.59478683660423 -1 10.4531191432062 572 383 217 241 102 463 652 100 819 366 133 348 M18365 GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. 7/13 Gene Ontology MF GO:0004859 0.000478262894296009 0.00292658883661929 470 380.727272727273 367 4.78365856412811e-05 52 0.790672182170614 -0.765459267939547 -1 6.77961508828785 466 134 849 149 52 582 587 367 258 419 325 349 M18521 GO_PALMITOYL_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYL_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. 11/16 Gene Ontology MF GO:0016290 0.0708416310429209 0.11227730203029 395 412.272727272727 367 0.0066573846035877 172 0.979709048974878 1.20049493935439 1 3.13585007983651 357 253 293 172 321 392 504 862 622 392 367 350 M18592 GO_DYNEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_BINDING.html Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. 37/55 Gene Ontology MF GO:0045502 0.105999571007668 0.157212846887777 560 402.181818181818 367 0.0101345705137712 157 0.976679483419668 0.802438447883035 1 2.64112100925182 235 327 427 560 780 187 157 335 367 556 493 351 M17865 GO_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. 435/804 Gene Ontology MF GO:0008233 0.00119533730073863 0.00561065302978915 825 450 368 0.000108726114905008 78 1.19591325015585 -1.09992174293211 -1 9.11872285904573 822 145 78 161 242 596 917 730 368 99 792 352 M19054 GO_DOPAMINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a dopamine receptor. 26/31 Gene Ontology MF GO:0050780 0.160649486630918 0.222548914013446 805 461.181818181818 368 0.0157945625961855 158 1.63150517983508 -1.47334430738924 -1 3.59178325057385 805 517 283 158 452 670 921 328 269 302 368 353 M18186 GO_PHOSPHATE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_BINDING.html Interacting selectively and non-covalently with phosphate. 14/18 Gene Ontology MF GO:0042301 0.0014277121442848 0.0062521612384794 415 410.545454545455 370 0.000129876319556211 50 1.30296516514506 1.42156510025462 1 9.72908938968871 412 538 317 424 370 892 798 50 127 243 345 354 M19067 GO_TAU_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. 16/26 Gene Ontology MF GO:0050321 0.146398953897031 0.205581509727745 465 409 371 0.0142870800818176 171 0.809607284777231 0.949304256788936 1 1.86484395890074 464 361 547 299 371 530 275 354 171 737 390 355 M17952 GO_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 28/38 Gene Ontology MF GO:0019212 0.256298410217391 0.323082852716057 450 419.272727272727 372 0.0265604805911671 83 1.21885372629902 -1.35291613647663 -1 2.00702110885677 335 222 449 321 816 447 266 701 83 600 372 356 M19086 GO_EPHRIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_ACTIVITY.html Combining with an ephrin to initiate a change in cell activity. 14/20 Gene Ontology MF GO:0005003 0.4581957203346 0.527238911069951 255 432.272727272727 372 0.0541900960369773 252 1.21262919645123 1.16454167449409 1 1.12066025396756 252 372 252 368 533 658 424 575 331 346 644 357 M17882 GO_CYTOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_BINDING.html Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 93/153 Gene Ontology MF GO:0019955 0.000141827104159881 0.00121340966892343 195 368.363636363636 373 1.28942043758201e-05 64 1.38052904269322 1.49359261158328 1 13.6482212780691 194 640 64 545 449 579 373 113 608 175 312 358 M18717 GO_AU_RICH_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AU_RICH_ELEMENT_BINDING.html Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. 23/26 Gene Ontology MF GO:0017091 0.073121294070203 0.115494146531398 240 403.818181818182 373 0.00687919000262636 173 0.906515925895685 0.981776651247915 1 2.86198944681458 237 228 486 414 323 373 173 689 663 625 231 359 M17960 GO_SYNTAXIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_BINDING.html Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. 91/123 Gene Ontology MF GO:0019905 0.0664071328045018 0.106713375150191 650 420.454545454545 374 0.00622733275542669 155 1.16372472288448 -1.32099317713116 -1 3.81664708799721 648 171 462 155 360 704 885 250 374 430 186 360 M18414 GO_STEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 14/25 Gene Ontology MF GO:0015248 0.00152737075465296 0.00656414221999691 315 455.090909090909 375 0.000138948379819665 50 1.50886037984121 -1.59478683660423 -1 11.1619439694312 825 375 313 337 80 776 646 311 818 475 50 361 M18616 GO_METAL_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_CLUSTER_BINDING.html Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. 64/69 Gene Ontology MF GO:0051540 0.0803562875767687 0.124579210941165 105 474.909090909091 375 0.00758643598645352 104 0.870505621247142 -0.800834329908196 -1 2.65010800942588 104 847 682 692 864 154 195 270 375 675 366 362 M19210 GO_HEXOSAMINIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSAMINIDASE_ACTIVITY.html Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. 15/18 Gene Ontology MF GO:0015929 0.000233873548005603 0.00174273514804175 825 378.545454545455 375 2.12634921731662e-05 5 1.43968941695193 -0.849531665934216 -1 13.4653522499507 821 241 331 188 724 450 584 16 5 375 429 363 M18416 GO_RNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with an RNA polymerase molecule or complex. 44/48 Gene Ontology MF GO:0070063 0.0571463881674772 0.0947993943747737 375 431.545454545455 376 0.00533519385229373 146 0.751946250945404 0.802720882049809 1 2.58886293037842 374 319 708 392 300 403 343 376 146 743 643 364 M18575 GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 327/580 Gene Ontology MF GO:0022890 2.42039491828491e-10 1.31555582617368e-08 530 327 377 2.20035901686472e-11 14 1.24350273925158 -1.20991040862952 -1 33.2598924303075 528 150 14 173 663 197 518 474 470 33 377 365 M17894 GO_PHOSPHOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_BINDING.html Interacting selectively and non-covalently with a phosphorylated protein. 69/84 Gene Ontology MF GO:0051219 0.041837365086365 0.0723927440820248 380 322.545454545455 378 0.00387771221536649 26 1.0672905282465 -1.03243909647478 -1 4.10924790122033 378 26 464 146 630 169 389 446 232 561 107 366 M18426 GO_COPPER_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_BINDING.html Interacting selectively and non-covalently with copper (Cu) ions. 44/68 Gene Ontology MF GO:0005507 0.00244431971284162 0.00899821280743289 295 411.818181818182 378 0.000222458156081177 101 1.56953740145238 -1.5501813824296 -1 10.8815889519693 291 713 111 691 101 485 721 179 574 286 378 367 M18641 GO_MHC_CLASS_I_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 33/68 Gene Ontology MF GO:0042288 0.00147521512593718 0.00642971120927336 75 397.363636363636 378 0.000134200478592497 6 0.857899220114834 -0.808147076688145 -1 6.36211078425981 73 720 569 710 378 6 29 267 852 724 43 368 M18723 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. 28/32 Gene Ontology MF GO:0016538 0.0692841443892263 0.110186832040697 210 434.909090909091 379 0.00650612940840529 130 0.814343826686018 0.808229779361256 1 2.62502937816119 209 515 609 653 827 144 130 285 350 683 379 369 M19227 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. 48/72 Gene Ontology MF GO:0043028 0.378182310887972 0.45089091001353 195 402.727272727273 380 0.0422721920391621 194 0.984458077882099 -1.00436860513126 -1 1.13237858870691 731 195 374 196 504 423 380 634 194 209 590 370 M18013 GO_LEUCINE_ZIPPER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUCINE_ZIPPER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. 11/14 Gene Ontology MF GO:0043522 0.115780988308124 0.169007319426077 155 313.090909090909 381 0.0111240735316261 151 0.927818575129566 1.05018953244781 1 2.40877490701706 151 257 489 381 401 201 165 391 154 389 465 371 M18038 GO_ADENYLYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an adenylyl group to an acceptor. 30/34 Gene Ontology MF GO:0070566 0.0565074700182718 0.0940164184120037 265 484.727272727273 381 0.00527393747792069 115 0.720635784365135 -0.75324181406548 -1 2.48887006167804 263 657 669 885 381 242 115 366 778 766 210 372 M18266 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a protein serine/threonine kinase. 23/25 Gene Ontology MF GO:0043539 0.000161841347919398 0.00134721986916688 655 416.090909090909 381 1.47139322620854e-05 27 0.947998341876905 -0.723768543971116 -1 9.21824638209132 652 345 381 436 27 325 213 237 821 622 518 373 M19039 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. 13/76 Gene Ontology MF GO:0016712 0.0149799443285136 0.0320404364804318 385 433 382 0.00137117516362804 118 1.46178788399242 -1.51800836535791 -1 7.39461222556311 382 377 118 312 778 606 383 865 616 147 179 374 M17982 GO_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 159/232 Gene Ontology MF GO:0004713 0.00426822272760072 0.0134601972706589 170 388.818181818182 383 0.000388775097603807 93 1.1699831087556 1.26493417673614 1 7.41032483992158 170 166 93 503 784 477 305 383 660 211 525 375 M18056 GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. 18/21 Gene Ontology MF GO:1990939 0.00722644879841812 0.0189291961464608 370 409.727272727273 385 0.000659117782508324 51 1.4136815296333 -1.54614239316088 -1 8.24789849357632 366 727 385 502 754 521 362 109 51 437 293 376 M18976 GO_MHC_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 41/83 Gene Ontology MF GO:0042287 0.00168606021876314 0.00701544965029157 40 404.636363636364 386 0.000153395798936333 7 0.87403889352609 -0.834103866465446 -1 6.36985596324467 37 715 495 779 386 7 47 332 846 723 84 377 M19111 GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY.html Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 9/27 Gene Ontology MF GO:0005326 0.00208687832292395 0.0079232916062668 350 426 386 0.000208884069457748 67 1.28429759001693 1.5489706979881 1 9.14061499169365 347 385 915 460 626 439 386 67 522 339 200 378 M18157 GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY.html Combining with a neuropeptide to initiate a change in cell activity. 12/49 Gene Ontology MF GO:0008188 0.0137665810320626 0.0298599081540512 415 398.818181818182 388 0.00125940802134385 138 1.84360681236754 -1.69361796683024 -1 9.52408893025753 415 813 154 763 280 388 400 144 709 183 138 379 M18628 GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 77/82 Gene Ontology MF GO:0005089 0.246899153372701 0.313824030803549 450 419.181818181818 388 0.0254484186427988 162 1.07895097319258 1.0850183275172 1 1.82014021044354 450 177 240 261 894 293 396 660 388 162 690 380 M18232 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 72/118 Gene Ontology MF GO:0003705 0.0920361662762511 0.140564326676456 65 416.636363636364 389 0.00873893087571793 65 1.00274331540818 0.99078326260903 1 2.87781049526995 65 708 389 819 396 225 149 282 686 482 382 381 M17881 GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. 122/204 Gene Ontology MF GO:0022853 0.00151882410803113 0.0065579134384148 750 408 391 0.000138170334562385 4 1.20081650492185 -1.12589152918301 -1 8.87988685282924 749 4 80 195 705 391 697 830 247 109 481 382 M18692 GO_N_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. 91/116 Gene Ontology MF GO:0016410 0.0231734164674923 0.0448528811151323 270 438.545454545455 392 0.00212919745796282 206 0.869409094074184 0.863974097242804 1 3.95678145052503 270 495 728 577 238 361 278 392 206 777 502 383 M18445 GO_PYRIDOXAL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDOXAL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. 40/53 Gene Ontology MF GO:0030170 0.0302976423807981 0.0562149027306374 810 506 394 0.00279301066664021 257 1.0031487324088 -1.1994126962207 -1 4.23507756306924 809 323 341 358 257 663 864 394 721 504 332 384 M18942 GO_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 11/22 Gene Ontology MF GO:0016502 0.0336326529602039 0.061054167652708 395 456.636363636364 394 0.00310528139268264 199 1.40515169338945 1.18520563137205 1 5.77081346052777 371 619 199 554 266 481 391 286 848 394 614 385 M18950 GO_ACTIN_MONOMER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MONOMER_BINDING.html Interacting selectively and non-covalently with monomeric actin, also known as G-actin. 24/36 Gene Ontology MF GO:0003785 0.232538094219959 0.300931651343476 555 442.545454545455 394 0.0237734367125967 198 1.09428258906737 -1.12848627658574 -1 1.91405882454069 555 340 394 198 559 271 341 782 673 446 309 386 M18455 GO_CO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CO_SMAD_BINDING.html Interacting selectively and non-covalently with a common mediator SMAD signaling protein. 13/19 Gene Ontology MF GO:0070410 0.0106672108019742 0.0251113535627992 870 419.545454545455 395 0.000974480645516141 30 1.54329878558892 -1.34546025571987 -1 8.36300863336222 867 252 395 203 177 772 703 137 30 450 629 387 M18294 GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription. 30/36 Gene Ontology MF GO:0001103 0.0962689126304874 0.14558506590928 555 402.727272727273 396 0.00915992020621491 162 0.94421303614341 -0.872859179811058 -1 2.65953732949461 554 332 606 396 343 177 436 600 162 546 278 388 M18363 GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. 16/70 Gene Ontology MF GO:0030594 0.136372479864813 0.193721367342737 515 351.090909090909 396 0.0132400880695022 59 1.2787382137629 1.61372340791371 1 3.07157636847617 365 235 192 125 436 623 511 406 59 514 396 389 M19175 GO_ACID_THIOL_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_THIOL_LIGASE_ACTIVITY.html Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 13/20 Gene Ontology MF GO:0016878 0.0584988833704289 0.096351102021883 400 361.727272727273 397 0.00546498912374561 112 0.922811890897143 -1.0163254374349 -1 3.16054708501843 397 112 425 134 674 356 553 441 295 451 141 390 M18473 GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. 20/55 Gene Ontology MF GO:0005231 0.0254964357238052 0.0487757900803231 860 450 398 0.00234516420442115 128 1.56631514019534 -1.40212262596325 -1 6.95421632558866 857 230 128 192 398 700 789 415 253 189 799 391 M17921 GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a sulfur compound from one side of the membrane to the other. 17/29 Gene Ontology MF GO:1901682 0.00140691518230996 0.00622004606915981 180 478.545454545455 399 0.000127983247331101 49 0.984589209907823 1.06697436720856 1 7.35336352143048 179 605 399 764 881 297 390 49 730 640 330 392 M18126 GO_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 194/233 Gene Ontology MF GO:0019207 0.304166637613689 0.373736666429586 915 591 399 0.0324302208835141 325 1.12407846921623 -1.10382933474876 -1 1.60759094073 911 399 330 328 792 859 901 914 392 325 350 393 M19050 GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. 165/201 Gene Ontology MF GO:0005057 0.00577426225782821 0.0160222772559558 615 461 399 0.000526315789473684 54 1.02216478609792 -1.01593658916519 -1 6.20831220363926 612 164 370 54 482 816 736 399 311 287 840 394 M19174 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. 11/12 Gene Ontology MF GO:0016861 0.000315284938331757 0.00214208296337164 375 454.363636363636 399 2.86663755731779e-05 43 0.663819943332491 -0.746815797963276 -1 5.99358136609164 373 686 650 702 43 399 355 302 327 681 480 395 M18814 GO_1_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 19/24 Gene Ontology MF GO:0005545 0.00577426225782821 0.0160222772559558 435 387.636363636364 400 0.000526315789473684 34 1.02117498932618 0.981581249609399 1 6.20227698928915 435 84 400 34 920 593 509 363 156 173 597 396 M19151 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS.html Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. 114/156 Gene Ontology MF GO:0016810 0.00174178052913437 0.00710009981117256 60 314.909090909091 400 0.000158469187208827 8 1.02678351794393 -1.05231084244017 -1 7.46910932381082 59 567 579 604 437 8 117 56 400 607 30 397 M17917 GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 143/194 Gene Ontology MF GO:0008234 0.00340552826217589 0.0116205553732678 305 421.545454545455 401 0.000310073760156462 112 0.942008416731809 0.956775542572147 1 6.16587416754837 302 296 621 270 112 534 401 502 302 594 703 398 M17969 GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. 24/29 Gene Ontology MF GO:0016411 0.00114653087330867 0.00548909081314619 560 334.454545454545 401 0.000104284438604139 73 0.968238332267162 -1.13895697220889 -1 7.40938783854585 556 439 401 306 73 449 554 98 137 445 221 399 M18472 GO_ALPHA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. 28/35 Gene Ontology MF GO:0043014 0.0536482296210419 0.0898024713221788 595 480.181818181818 402 0.00500026853197275 207 1.14333462367982 1.14261666320471 1 4.04031868491156 592 659 402 559 862 380 330 232 207 258 801 400 M18551 GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. 15/22 Gene Ontology MF GO:0004653 0.0951712640238082 0.144397779898192 660 430.636363636364 402 0.00905057610901188 108 1.32653081794758 -1.64430275614684 -1 3.7622478205347 657 108 177 120 443 814 283 402 762 167 804 401 M18681 GO_GLUTATHIONE_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_TRANSFERASE_ACTIVITY.html Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. 23/38 Gene Ontology MF GO:0004364 0.0762366830438786 0.119394398529735 405 336 402 0.00718311274570071 76 1.16210760362355 -1.051376334494 -1 3.61883624171853 402 76 284 215 403 137 366 463 505 426 419 402 M18611 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS.html Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). 18/33 Gene Ontology MF GO:0016769 0.000493326505645418 0.00299890586326557 445 345.363636363636 403 4.48579239624468e-05 50 0.926587326018531 -0.978717602278663 -1 7.91582765866427 444 91 304 401 50 494 403 280 441 440 451 403 M18430 GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. 23/28 Gene Ontology MF GO:0003950 0.0155653516342555 0.0331391357374473 175 345.909090909091 404 0.00142514384743118 45 0.815498587798478 -0.848432790955182 -1 4.07400371436757 173 587 652 466 404 45 74 434 106 715 149 404 M18622 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. 16/17 Gene Ontology MF GO:0016646 0.384987662045011 0.45603917459157 435 416 404 0.043229842650046 66 1.48087245116789 -1.38620106699014 -1 1.69081784589753 433 453 362 369 638 404 326 477 66 385 663 405 M18485 GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of modified amino acids from one side of a membrane to the other. 12/17 Gene Ontology MF GO:0072349 3.92597034028235e-05 0.000465076486464216 5 333 406 3.56912763838974e-06 2 0.999182676356414 0.999182676356414 1 11.2848188242345 19 681 406 735 847 28 2 4 520 412 9 406 M18826 GO_HSP70_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP70_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. 31/36 Gene Ontology MF GO:0030544 0.0420602390834735 0.0726331181678448 225 433 406 0.00389877840869825 90 1.00186998015423 -0.986955905722968 -1 3.85098179332664 221 785 550 745 406 90 320 235 725 559 127 407 M17853 GO_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently with a polymer of ubiqutin. 44/46 Gene Ontology MF GO:0031593 0.0545172683011884 0.0910921445032515 410 429.181818181818 407 0.00508336797899389 142 0.670410614369717 -0.598754748940945 -1 2.34496188099943 251 578 760 532 297 142 302 407 409 809 234 408 M18614 GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Increases the activity of a peptidase that is involved in the apoptotic process. 22/28 Gene Ontology MF GO:0016505 0.0608081100365995 0.0994454755288813 335 388 408 0.00568699158163976 61 0.869159190371632 0.917157890448436 1 2.93485481702012 332 661 537 108 824 427 121 281 61 508 408 409 M18580 GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 87/102 Gene Ontology MF GO:0004725 0.00577426225782821 0.0160222772559558 685 418.363636363636 409 0.000526315789473684 15 1.12217220867893 -1.06825779111776 -1 6.81810024206229 682 15 291 31 599 431 874 409 700 257 313 410 M18262 GO_DAMAGED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DAMAGED_DNA_BINDING.html Interacting selectively and non-covalently with damaged DNA. 67/77 Gene Ontology MF GO:0003684 0.0125177952826832 0.0280634746129833 95 411.090909090909 412 0.00114450845083034 88 0.765263132835473 -0.780007006023915 -1 4.00920247078835 92 412 701 712 192 88 135 451 786 776 177 411 M17876 GO_SYNTAXIN_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_1_BINDING.html Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. 20/27 Gene Ontology MF GO:0017075 0.0309545181784936 0.057318586767391 155 407.181818181818 413 0.00285443934874772 87 1.02231272014055 1.02231272014055 1 4.2871283926918 155 596 500 620 883 97 87 355 413 485 288 412 M18276 GO_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_ACTIVITY.html Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 9/27 Gene Ontology MF GO:0008066 0.00525070999993344 0.0157521299998003 675 442.818181818182 413 0.000526315789473684 45 1.69137718865813 -1.14008969386263 -1 10.3312097505446 672 259 840 45 369 727 597 413 60 334 555 413 M18665 GO_WIDE_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WIDE_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. 12/27 Gene Ontology MF GO:0022829 0.000694518518569461 0.00381985185213203 520 416.909090909091 413 6.31579880214169e-05 59 1.0788309586408 -1.00703441877109 -1 8.83539185915629 518 548 384 419 59 371 406 608 344 413 516 414 M18914 GO_CXCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CXCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. 11/15 Gene Ontology MF GO:0045236 0.236771895391795 0.304279876692654 185 453.454545454545 413 0.0242642576164161 181 1.36634513641107 1.00781639668985 1 2.37366828992189 181 685 287 647 431 334 311 789 635 275 413 415 M17943 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION.html Any protein binding that is involved in cell adhesion. 18/21 Gene Ontology MF GO:0098631 0.202184745280816 0.267265671873353 900 545.454545454545 414 0.0203249887792129 234 1.34330511001366 -1.68772924851689 -1 2.59023144047466 896 357 342 316 414 766 907 381 723 234 664 416 M18486 GO_SCAFFOLD_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAFFOLD_PROTEIN_BINDING.html Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. 60/84 Gene Ontology MF GO:0097110 8.23497187834067e-06 0.00011356886590428 485 447.090909090909 414 7.4863660939945e-07 53 1.53733929171832 -1.5415115430638 -1 20.5727229569324 485 414 53 504 917 317 810 338 773 95 212 417 M19182 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 37/89 Gene Ontology MF GO:0004869 0.0182418681901315 0.0373735836090498 800 401.090909090909 414 0.00167226407694892 48 1.22014815827753 -1.24083583967539 -1 5.89114127917817 800 48 153 121 655 665 775 414 430 83 268 418 M18010 GO_RETINOIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_BINDING.html Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. 8/31 Gene Ontology MF GO:0001972 6.17617858427363e-05 0.000648498751348731 615 412.090909090909 415 6.17635024430685e-06 13 0.956172278377851 -0.872789669758941 -1 10.3291206032985 611 263 812 415 13 178 452 287 716 462 324 419 M18892 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. 39/49 Gene Ontology MF GO:0001105 0.0330536756945887 0.0602398349936883 665 459.454545454545 415 0.00305099916889437 110 1.19216477167722 -1.20845683176342 -1 4.91603241094449 665 324 305 110 263 488 415 712 620 342 810 420 M17900 GO_QUINONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_BINDING.html Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. 14/20 Gene Ontology MF GO:0048038 0.241461864546042 0.309446273010462 380 381.272727272727 416 0.0248108596808158 77 1.56066176634347 -1.4095499563764 -1 2.67593540419738 430 460 377 416 467 294 445 379 77 473 376 421 M17916 GO_PROTEIN_SELF_ASSOCIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SELF_ASSOCIATION.html Interacting selectively and non-covalently with a domain within the same polypeptide. 56/71 Gene Ontology MF GO:0043621 0.230880803268233 0.299205977867949 425 462.090909090909 416 0.0235819785200343 192 1.03578884982245 -1.09262323810704 -1 1.81923418345898 425 192 360 455 889 411 274 371 775 416 515 422 M18904 GO_TETRAPYRROLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BINDING.html Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. 76/185 Gene Ontology MF GO:0046906 0.000334737969788966 0.00222675215035212 760 450.727272727273 416 3.04353556577764e-05 18 1.38580484551737 -1.42054906712676 -1 12.4594793887698 756 18 68 349 232 888 827 416 439 72 893 423 M18528 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the transforming growth factor beta receptor. 37/59 Gene Ontology MF GO:0005160 0.0182418681901315 0.0373735836090498 500 429.818181818182 417 0.00167226407694892 82 1.41748853164172 -1.28872323424602 -1 6.84786791475824 498 325 180 131 417 861 809 457 283 82 685 424 M18304 GO_GLUCOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_BINDING.html Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. 12/16 Gene Ontology MF GO:0005536 0.233836855294638 0.30201892594737 755 493.090909090909 418 0.0239237386817726 103 1.28016152478796 -1.61897168729938 -1 2.23649946973671 755 544 354 281 783 807 770 418 103 299 310 425 M18348 GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. 316/410 Gene Ontology MF GO:0042578 0.27480409143847 0.343576875216783 800 482.454545454545 420 0.0287878154671941 58 1.12077267909462 -1.03496819352179 -1 1.74189043680936 798 287 221 58 456 420 916 720 377 219 835 426 M18659 GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). 23/28 Gene Ontology MF GO:0036442 0.00577426225782821 0.0160222772559558 425 407.454545454545 422 0.000526315789473684 56 0.773632977340673 -0.53947354458942 -1 4.69290744430707 422 80 596 56 879 246 307 632 163 624 477 427 M19157 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 24/56 Gene Ontology MF GO:0005245 0.0228569684443934 0.0445566220308427 320 460.727272727273 424 0.00209981402024546 184 1.31571185431896 1.2627960367458 1 6.01327372361093 319 660 184 788 235 444 347 424 796 549 322 428 M18874 GO_RAC_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GTPASE_BINDING.html Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. 49/56 Gene Ontology MF GO:0048365 0.222228935007304 0.288803848026369 795 546.090909090909 425 0.0225885220076315 78 1.10564651593333 -1.12851514276819 -1 2.00127400360214 794 316 416 291 425 851 759 885 78 398 794 429 M19115 GO_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 1297/2125 Gene Ontology MF GO:0005102 8.95563438591873e-10 4.13750308629445e-08 425 451.545454545455 425 8.95563438952788e-11 5 1.22597133600017 1.29282593193331 1 30.7185827240456 255 394 916 487 576 370 482 425 636 5 421 430 M18036 GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY.html Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. 15/15 Gene Ontology MF GO:0034450 0.000141535022094705 0.00121340966892343 570 388 426 1.28676480403003e-05 24 0.678916769563116 -0.483510918758774 -1 6.69959287393205 570 245 616 426 24 265 276 500 228 614 504 431 M18802 GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. 49/61 Gene Ontology MF GO:0005548 0.167227990950108 0.229938487556399 540 427 426 0.01649832985589 36 1.07954109284892 -1.04874880261088 -1 2.31640314328461 538 36 201 78 804 426 880 568 602 163 401 432 M19041 GO_NOTCH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_BINDING.html Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. 23/30 Gene Ontology MF GO:0005112 0.213238348247339 0.279478345788002 245 518.545454545455 427 0.0215667598488153 244 1.10141272266173 1.10352943357574 1 2.04684225338543 244 663 348 844 710 254 303 763 804 427 344 433 M19229 GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY.html Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. 18/21 Gene Ontology MF GO:0030296 0.348671896024533 0.420591164395128 530 436 427 0.0382267125094271 96 0.966450073763688 1.09357233381444 1 1.21038740455976 527 96 332 248 627 560 421 427 319 441 798 434 M19192 GO_ARMADILLO_REPEAT_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARMADILLO_REPEAT_DOMAIN_BINDING.html Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. 17/19 Gene Ontology MF GO:0070016 0.0471654147900694 0.0799648500294021 280 482.181818181818 428 0.00438254695413723 238 0.63117578549179 0.682797909446878 1 2.3276012267606 278 733 655 824 286 312 260 238 544 746 428 435 M18238 GO_STEROID_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_ACTIVITY.html Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. 42/63 Gene Ontology MF GO:0003707 0.001156148369283 0.00550660357328606 865 448.272727272727 429 0.000105159672551156 45 1.39179288965194 -1.56393423980525 -1 10.6546893665295 865 45 175 103 74 841 883 924 429 118 474 436 M18251 GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a monosaccharide from one side of a membrane to the other. 16/25 Gene Ontology MF GO:0015145 0.0235058262970689 0.0453431805814022 510 432.090909090909 429 0.0021600723326698 87 1.65353918331697 1.28012929459269 1 7.52081517657453 507 242 135 370 716 809 593 429 92 87 773 437 M18745 GO_ACTIVIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_BINDING.html Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits. 15/16 Gene Ontology MF GO:0048185 0.126164379680629 0.182149823163908 460 404.909090909091 429 0.0121854216545892 141 0.995538918043934 1.02522003301002 1 2.47639111447593 268 456 429 204 776 602 456 520 141 373 229 438 M18529 GO_WW_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WW_DOMAIN_BINDING.html Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. 29/34 Gene Ontology MF GO:0050699 0.0319211151281338 0.0585220444015786 290 505.727272727273 430 0.00294490091906998 89 1.07586245909442 1.05193418779529 1 4.47998929259053 290 430 412 234 855 401 89 856 768 689 539 439 M18399 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS.html Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). 210/262 Gene Ontology MF GO:0016746 0.0118762792796328 0.0269128988659619 525 443.090909090909 431 0.00108553453272937 189 1.01316833906219 -1.08646025353925 -1 5.37839693119524 521 398 607 305 189 531 670 431 212 618 392 440 M18755 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. 110/216 Gene Ontology MF GO:0016705 0.001020428624907 0.00509662729413008 595 445.545454545455 432 9.28092944645459e-05 51 1.46155307277669 -1.52329207104409 -1 11.3567399360626 432 568 77 595 413 364 410 695 595 51 701 441 M19156 GO_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. 867/1395 Gene Ontology MF GO:0005215 2.29325922436315e-07 4.708825607359e-06 600 410 432 2.29325946101989e-08 12 1.25122769778587 -1.18099051604385 -1 22.6139246906222 600 139 918 57 520 291 645 527 369 12 432 442 M18626 GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY.html Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. 4/8 Gene Ontology MF GO:0016175 0.0604169675796755 0.0991567993669985 400 490.545454545455 433 0.00621253039959261 153 1.3846259116234 1.3846259116234 1 4.69573779282699 396 752 871 666 314 269 153 594 433 522 426 443 M18577 GO_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BINDING.html Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. 56/74 Gene Ontology MF GO:0051287 0.00867322307226123 0.0215431669859392 745 438.818181818182 434 0.000791600553069217 31 1.14809511783376 -1.05222561860274 -1 6.47476287003422 743 31 434 96 165 369 549 918 114 557 851 444 M17862 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase. 30/31 Gene Ontology MF GO:0051019 0.205895785123956 0.271008127428113 670 407.909090909091 435 0.0207401364597975 61 1.08838145724384 0.959152837519278 1 2.07174568232785 669 61 379 105 558 248 435 857 112 453 610 445 M18936 GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. 23/27 Gene Ontology MF GO:0043325 0.0114882354253285 0.0264057948582177 535 428.272727272727 435 0.00104987894569426 134 0.965510745223644 1.12129784511398 1 5.15135614230081 242 344 448 435 767 535 262 134 694 534 316 446 M18520 GO_SUMO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_BINDING.html Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. 15/17 Gene Ontology MF GO:0032183 0.0207021493998603 0.0410965252707857 150 388.909090909091 436 0.00189996033960094 147 1.08039745097141 1.18339287259427 1 5.06228655645652 162 676 519 522 230 245 147 467 436 726 148 447 M19119 GO_CADHERIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CADHERIN_BINDING.html Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. 29/34 Gene Ontology MF GO:0045296 0.0130428101282304 0.0287626648173864 285 424.363636363636 436 0.00119279845694357 142 1.31238602617665 -1.58599346876553 -1 6.8452799441917 679 656 311 285 600 454 619 142 204 282 436 448 M19120 GO_SEMAPHORIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with semaphorin receptors. 27/29 Gene Ontology MF GO:0030215 0.0366448359118473 0.0649900736709154 735 471 436 0.00338816762721556 140 1.49031747922822 1.67295411682322 1 5.98471926932915 734 436 140 350 285 335 668 656 591 239 747 449 M18602 GO_DRUG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_BINDING.html Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 120/211 Gene Ontology MF GO:0008144 0.0764750801557448 0.119565099938931 220 427.909090909091 437 0.00720640801301685 195 1.21408720163769 1.22315590453606 1 3.77922893914946 220 704 232 815 620 237 458 262 437 527 195 450 M18780 GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. 26/29 Gene Ontology MF GO:0015605 0.00148991477752559 0.00646329227433635 70 378.181818181818 437 0.000135538614197566 52 0.881205959605429 -0.859840291409929 -1 6.52883991261432 70 437 583 701 763 86 111 52 625 572 160 451 M19201 GO_THIOESTERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTERASE_BINDING.html Interacting selectively and non-covalently with any thioesterase enzyme. 15/16 Gene Ontology MF GO:0031996 0.0700672245676599 0.111240748282676 325 402.909090909091 437 0.00658214939267385 65 0.88295651814219 0.759621151319702 1 2.83584820686858 323 366 493 467 335 437 131 727 65 617 471 452 M18857 GO_SNARE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_BINDING.html Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 123/160 Gene Ontology MF GO:0000149 0.0680274654635194 0.10874978908009 590 418.545454545455 438 0.00638425477298249 5 1.0812245601744 -1.19427882377337 -1 3.51420512316218 587 5 565 242 383 438 835 312 490 589 158 453 M18544 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. 78/147 Gene Ontology MF GO:0015085 0.143960582451832 0.202773747233983 380 478.454545454545 439 0.0140314338232829 193 1.13207750280699 -1.24632443587373 -1 2.64024739391725 380 572 193 737 529 347 439 603 696 362 405 454 M18688 GO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 154/190 Gene Ontology MF GO:0016829 0.102201488098428 0.153620287227594 620 460.363636363636 439 0.00975300160963553 168 1.01273752759328 -0.928470338432159 -1 2.77405646869665 617 168 439 303 347 326 565 897 403 480 519 455 M18341 GO_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. 54/106 Gene Ontology MF GO:0005253 0.247255296996736 0.313824030803549 590 461.636363636364 440 0.0254903247727524 310 1.27297298421741 -1.19240787637798 -1 2.15180956305443 589 419 310 315 441 511 440 389 360 595 709 456 M18364 GO_DIACYLGLYCEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_BINDING.html Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. 11/14 Gene Ontology MF GO:0019992 0.0409367452321124 0.0709672656556695 440 458.909090909091 440 0.00379263039403611 103 0.896942183018201 -0.953137597415203 -1 3.47581667800973 440 125 420 558 839 315 103 475 827 543 403 457 M18804 GO_RETINOID_X_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOID_X_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a retinoid X receptor. 22/25 Gene Ontology MF GO:0046965 0.0257196825102748 0.0489999724525648 195 424.727272727273 441 0.00236594368267297 193 0.88596184187511 1.03569262915853 1 3.91701254403897 193 526 559 346 246 475 384 259 633 610 441 458 M19187 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 23/26 Gene Ontology MF GO:0016645 0.238329280841027 0.305855910412651 780 510.272727272727 441 0.0244454268457887 256 1.33002674979451 -1.26157476817539 -1 2.29979446896785 689 441 378 371 434 561 500 779 256 428 776 459 M18638 GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. 20/21 Gene Ontology MF GO:0034236 0.391415532170425 0.462490986861219 720 534.909090909091 442 0.0441432621821576 215 1.20959529453106 -1.09963293679565 -1 1.35157165960432 719 442 414 439 624 618 716 440 215 367 890 460 M18902 GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). 8/13 Gene Ontology MF GO:0005451 0.000668680079408046 0.00376744142300631 840 505 443 6.688813745331e-05 62 1.12929580326363 -0.545940053593954 -1 9.27283610797876 836 555 894 429 62 434 308 387 443 466 741 461 M18125 GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. 19/36 Gene Ontology MF GO:0005227 0.0749885068452803 0.118221394335749 325 498.181818181818 444 0.00706123481573696 129 1.38059658771834 -1.11383280800272 -1 4.3238849702751 842 444 229 323 324 572 871 586 129 259 901 462 M18407 GO_FIBROBLAST_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with a fibroblast growth factor. 35/55 Gene Ontology MF GO:0017134 0.0900141215535768 0.138391095366897 525 457.454545454545 444 0.00853844750969139 188 1.13559061503476 1.2726370119748 1 3.28838794200998 257 718 245 579 358 524 402 525 792 444 188 463 M19035 GO_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glutamate receptor. 43/50 Gene Ontology MF GO:0035254 0.0711075825608407 0.112505832681878 515 440.818181818182 444 0.00668323550091806 256 1.13580632449447 0.883475015817918 1 3.6359452197621 513 422 327 390 521 504 268 256 444 483 721 464 M18110 GO_RHO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GTPASE_BINDING.html Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. 96/106 Gene Ontology MF GO:0017048 0.266217373348811 0.333312808908267 700 468.818181818182 445 0.0277479739876209 176 1.06495512782817 -1.05864409443999 -1 1.70157377163408 698 305 491 318 445 656 781 516 176 376 395 465 M18695 GO_PROTEIN_PHOSPHATASE_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_1_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 1. 19/30 Gene Ontology MF GO:0008157 0.173661525482719 0.237022006717382 320 446.272727272727 445 0.017191493584854 184 0.85149658814457 -0.543523507098913 -1 1.7838479013989 318 445 557 475 756 266 271 343 184 673 621 466 M18776 GO_NEUREXIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUREXIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. 12/14 Gene Ontology MF GO:0042043 0.109568240938412 0.161468986646081 445 453.363636363636 445 0.0104944370166268 294 1.03054174956463 -0.919323931956275 -1 2.74750756754243 445 543 453 420 654 402 470 298 594 414 294 467 M17971 GO_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for hormones. 178/307 Gene Ontology MF GO:0051427 0.176428737084134 0.240088590671193 245 476.454545454545 446 0.0174911493188995 241 0.866398691586157 0.932790612634008 1 1.79906361788504 241 401 709 588 389 333 459 464 442 769 446 468 M19036 GO_CYTOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_ACTIVITY.html Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 50/95 Gene Ontology MF GO:0004896 0.00278098801504349 0.00999857169610965 450 468.272727272727 446 0.000253137241405069 85 1.4268474431457 1.33595239688483 1 9.66825179590534 446 504 85 400 916 555 371 246 599 296 733 469 M17903 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. 29/30 Gene Ontology MF GO:0031434 0.00814904258891574 0.0206293571292004 125 383 447 0.000743580455148839 41 1.28013942818944 1.12620815850507 1 7.30406958439513 122 786 543 537 447 66 41 196 695 611 169 470 M17850 GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 54/77 Gene Ontology MF GO:0004712 0.200691914214962 0.266382043687909 385 498.727272727273 448 0.0201584832810505 34 0.816812254276057 -0.672898815200594 -1 1.56950031683228 385 34 560 378 410 680 381 681 448 787 742 471 M17870 GO_SIGNAL_TRANSDUCER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCER_ACTIVITY.html Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 855/2441 Gene Ontology MF GO:0004871 2.65042626560413e-12 2.44899386941821e-10 385 415.363636363636 448 2.65042626560728e-13 3 1.25136143413285 1.29868704609631 1 40.8234166139648 381 140 801 256 448 351 471 542 516 3 660 472 M18499 GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. 59/77 Gene Ontology MF GO:0000979 0.518814131667683 0.591102660494376 910 534.636363636364 448 0.0643372255876768 132 1.20242224510567 -1.1565071894928 -1 0.908236471923739 908 189 347 253 628 873 829 887 132 387 448 473 M18179 GO_METALLOCARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOCARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 13/28 Gene Ontology MF GO:0004181 0.247201281643111 0.313824030803549 450 520.818181818182 449 0.0254839678223854 303 1.16548031381783 1.67851020066792 1 1.96805708974725 303 810 314 774 440 526 449 450 829 447 387 474 M17993 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 24/39 Gene Ontology MF GO:0001205 0.0167178431429781 0.0351874420594801 50 465.181818181818 450 0.00153147732126656 47 0.744933584005696 0.777633659766953 1 3.65348148046425 47 789 450 829 757 116 65 265 861 636 302 475 M18839 GO_GLYCOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_BINDING.html Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 130/193 Gene Ontology MF GO:0001948 8.03434420142449e-06 0.00011356886590428 325 460.818181818182 451 7.30397594799614e-07 51 1.25539415061073 1.18897540944073 1 16.7952742425457 322 405 51 451 116 709 566 776 728 160 785 476 M18870 GO_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY.html A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. 6/11 Gene Ontology MF GO:0015279 0.00368836757213366 0.0122591785491061 505 434.090909090909 452 0.000369450373576601 88 1.40055521979912 -1.40055521979912 -1 9.06856085886084 505 477 890 422 560 452 244 88 293 585 259 477 M18687 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. 34/37 Gene Ontology MF GO:0032266 0.00556150628342377 0.0160222772559558 245 445.909090909091 453 0.000506874135835892 139 1.03600477092589 1.21924215097788 1 6.29270051184923 245 655 603 716 139 336 188 453 550 593 427 478 M17947 GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 14/21 Gene Ontology MF GO:0008308 0.012862339948997 0.0284325409398881 440 453.272727272727 454 0.00117619647182537 69 1.10637525343738 -0.712873188945973 -1 5.78577752736185 436 608 571 244 454 820 493 141 69 719 431 479 M18007 GO_NEUROPEPTIDE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neuropeptide receptor. 13/31 Gene Ontology MF GO:0071855 0.00135877596812992 0.00603610093534639 120 468.636363636364 454 0.000123601446281949 7 1.18414071125879 1.18414071125879 1 8.90105569973656 119 900 294 854 840 47 7 454 880 576 184 480 M18541 GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. 19/25 Gene Ontology MF GO:0015035 1.117557296432e-05 0.000147517563129024 500 421.909090909091 454 1.01596633949683e-06 6 0.705642685148494 -0.753209158016401 -1 9.1575865865264 499 351 624 235 6 498 523 432 257 762 454 481 M18967 GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a sodium channel. 30/43 Gene Ontology MF GO:0017080 0.00374390157337403 0.0123548751921343 575 471.636363636364 454 0.000340935278776541 90 1.20806662930901 1.03024251595378 1 7.80501123096612 574 428 90 454 361 767 412 460 565 216 861 482 M18060 GO_ACTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. 362/479 Gene Ontology MF GO:0003779 0.130809313748739 0.186812683004381 835 476.181818181818 456 0.0126639241130595 145 1.05589786258118 -1.11671916645392 -1 2.58863621721281 833 286 316 302 368 468 815 773 456 145 476 483 M18556 GO_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 47/72 Gene Ontology MF GO:0043394 1.69488972098639e-07 3.91519525547856e-06 65 392.636363636364 456 1.54080895596496e-08 36 1.58637646704024 1.36105219287984 1 29.1095897783404 61 420 36 456 315 581 507 526 713 129 575 484 M18321 GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. 47/81 Gene Ontology MF GO:0004715 0.0638537689491998 0.102968381342165 655 443.636363636364 457 0.00598055259472349 40 0.941974190839468 1.105726245676 1 3.13438931890167 289 40 457 423 310 652 516 385 655 653 500 485 M18751 GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY.html Combining with a protein hormone to initiate a change in cell activity. 6/23 Gene Ontology MF GO:0016500 0.256722344358364 0.323176357203172 385 588.818181818182 457 0.0292327695221031 137 1.00820907079784 -1.27510971793434 -1 1.65554019650041 834 137 879 383 450 894 731 422 457 384 906 486 M18862 GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. 27/43 Gene Ontology MF GO:0005310 0.130542630969732 0.186720419529462 710 488 458 0.012636388695381 189 1.27012097522562 -1.16403223332169 -1 3.11967318708162 706 217 189 332 882 577 618 653 418 318 458 487 M18534 GO_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVITY.html Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 248/313 Gene Ontology MF GO:0016791 0.00577426225782821 0.0160222772559558 535 414.545454545455 459 0.000526315789473684 14 1.00929892834859 -1.01345756211259 -1 6.12986356495711 637 289 459 14 432 138 630 531 532 590 308 488 M18585 GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). 36/44 Gene Ontology MF GO:0016776 0.00713028121538059 0.0187703129430532 460 393.727272727273 459 0.000650317829553692 149 0.942678600402145 -1.02120577655356 -1 5.50354354293599 460 509 528 240 149 319 626 194 638 459 209 489 M18474 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. 10/10 Gene Ontology MF GO:0016723 0.0338249531736286 0.0611629290262873 365 512.272727272727 460 0.0031233171098009 267 1.19099936113765 -1.15363379937867 -1 4.88448725177488 533 814 460 696 267 737 782 365 318 365 298 490 M18151 GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. 244/498 Gene Ontology MF GO:0022803 2.18778848173534e-13 2.24612950791495e-11 745 422.272727272727 461 1.98889861975959e-14 7 1.42307252957096 -1.45686223568395 -1 51.4433021963006 745 291 7 210 595 461 872 570 513 38 343 491 M19145 GO_PROTEIN_PHOSPHATASE_2A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_2A_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. 40/44 Gene Ontology MF GO:0051721 0.0022123656200209 0.00827621794696078 485 398.727272727273 461 0.00020132668709467 97 0.955241345377452 -0.812222986867771 -1 6.73103242080267 483 200 461 157 97 482 287 254 662 588 715 492 M18661 GO_MAP_KINASE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. 13/14 Gene Ontology MF GO:0033549 0.131470809900923 0.187467636340205 620 449.909090909091 462 0.0127322578012605 146 1.29450046226411 1.31370462619874 1 3.1723939879646 619 462 235 496 865 339 237 840 223 146 487 493 M18490 GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 11/12 Gene Ontology MF GO:0015129 0.0224111551254873 0.0438726850337929 105 427.363636363636 464 0.00205843318332009 105 1.47822912478907 -1.77805546305787 -1 6.79276158223015 921 379 126 214 522 647 464 578 105 105 640 494 M19191 GO_HISTONE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 29/49 Gene Ontology MF GO:0035173 0.0118836176810741 0.0269128988659619 465 400.545454545455 465 0.00108620894773385 68 0.820334265304057 0.886443818923785 1 4.35012054974979 465 68 531 463 190 487 515 219 168 758 542 495 M18453 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 75/107 Gene Ontology MF GO:0004197 0.00547907902663664 0.0160222772559558 475 417.181818181818 466 0.000499342944457527 19 1.02591891871324 1.02406215113457 1 6.2312027562042 472 19 466 179 138 516 444 722 244 560 829 496 M19190 GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. 123/150 Gene Ontology MF GO:0001046 0.199884308241755 0.266128387342048 470 486.454545454545 467 0.0200685233540504 305 1.09159046957193 1.09046008396918 1 2.10718151415199 305 408 468 676 777 448 361 359 467 551 531 497 M18150 GO_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to an acceptor molecule. 96/114 Gene Ontology MF GO:0016407 0.013364553706984 0.029277983151094 165 425.727272727273 468 0.00122240344669551 155 0.843444865287601 0.863742922926466 1 4.36856547894295 163 494 761 580 199 301 250 509 155 803 468 498 M18514 GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. 9/12 Gene Ontology MF GO:0008970 0.0100778648123719 0.0239381673178192 865 526.090909090909 468 0.00101238621816694 183 1.24656999567536 -1.24695750300595 -1 6.83837010823985 863 260 864 405 183 611 447 489 468 337 860 499 M18579 GO_CHAPERONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_BINDING.html Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. 103/131 Gene Ontology MF GO:0051087 0.00840953481783484 0.0211727797593444 295 502.363636363636 468 0.000767441225876605 101 0.849444858275763 -0.832481619789608 -1 4.80592125113325 294 839 623 865 468 101 408 114 868 799 147 500 M19125 GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a chloride channel. 14/19 Gene Ontology MF GO:0017081 0.107526693631862 0.158967463865344 485 379.272727272727 468 0.0102884062023282 124 1.17446737877095 -1.30802575057293 -1 3.16166204135323 484 369 488 511 563 206 277 468 124 478 204 501 M18866 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. 11/23 Gene Ontology MF GO:0016863 0.129304887322776 0.185236768815884 350 465 469 0.0125086901398681 251 0.728656572353702 -0.728656572353702 -1 1.78795777563641 346 621 592 519 366 409 499 364 251 679 469 502 M18195 GO_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). 48/84 Gene Ontology MF GO:0015297 0.43119990772354 0.501799388836966 785 474.454545454545 470 0.05 39 1.1277538391394 -1.16471802262319 -1 1.12278781262794 781 39 322 232 574 631 823 539 371 470 437 503 M18805 GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. 42/74 Gene Ontology MF GO:0008028 3.09077670118924e-06 4.84047063033705e-05 655 431.454545454545 470 2.80980094856849e-07 30 1.42362399533492 -1.59126396178672 -1 20.8399927232039 651 43 48 90 701 755 805 820 333 30 470 504 M18011 GO_DIACYLGLYCEROL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_KINASE_ACTIVITY.html Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. 9/11 Gene Ontology MF GO:0004143 0.014714313592589 0.031545303386432 695 452.090909090909 473 0.00148126613082661 41 1.26283058085836 -1.40446068305404 -1 6.41387261936849 694 473 813 366 606 544 649 158 41 333 296 505 M18022 GO_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_ACTIVITY.html The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. 7/12 Gene Ontology MF GO:0009881 0.0314751955728446 0.057934423723722 370 476.272727272727 473 0.00319300999466345 94 1.54563987537166 1.80294296038019 1 6.46978788535687 370 692 814 683 473 235 94 550 681 277 370 506 M17927 GO_DNA_BINDING_BENDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BINDING_BENDING.html The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. 14/24 Gene Ontology MF GO:0008301 0.00647740251071905 0.0175003506429953 775 501.454545454545 474 0.000590595703749237 43 1.39109031164038 1.43778441047856 1 8.27674802830924 774 609 398 107 145 921 886 344 43 474 815 507 M18047 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS.html Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). 52/68 Gene Ontology MF GO:0016765 0.00457581464618604 0.0142358677881343 500 407 474 0.000416850887360735 127 1.08362956729183 -0.982154937454601 -1 6.77204267331331 388 576 474 497 127 129 359 497 510 503 417 508 M18570 GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. 69/83 Gene Ontology MF GO:0004843 0.0201635024454766 0.0404489806859301 165 521.727272727273 474 0.00185006474078654 164 0.744885886616653 0.826062932514269 1 3.50013607484644 164 413 747 820 228 474 257 437 812 800 587 509 M18145 GO_ADRENERGIC_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an adrenergic receptor. 26/30 Gene Ontology MF GO:0031690 0.128370466389422 0.184183712645692 400 471.545454545455 476 0.0124123947960858 182 1.54500330327839 -1.84324883160768 -1 3.83126353688308 399 519 299 476 730 708 182 694 376 223 581 510 M18411 GO_CATION_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 53/70 Gene Ontology MF GO:0019829 0.201043020595619 0.266382043687909 585 484.636363636364 476 0.0201976190973141 244 0.995059151710044 -0.940775035675455 -1 1.91729566817824 582 503 419 582 851 244 476 493 370 454 357 511 M18861 GO_PHOSPHATIDIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_BINDING.html Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 18/19 Gene Ontology MF GO:0070300 0.00510746597699437 0.015524008430075 460 411.727272727273 477 0.000465396547927127 122 0.952034508718535 1.18202022054504 1 5.82506224869972 458 532 477 578 132 514 184 122 799 553 180 512 M18064 GO_LYSINE_ACETYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_ACETYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. 21/21 Gene Ontology MF GO:0070577 0.206862267884003 0.271892938157638 470 557.636363636364 479 0.0208485446908363 342 0.613400997444335 0.577580067793881 1 1.15407717040569 469 347 693 479 415 505 395 834 342 779 876 513 M18187 GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. 13/18 Gene Ontology MF GO:0004550 0.0316060472372292 0.0580596175888663 590 489.636363636364 479 0.00291540542787044 260 0.938939926225693 -0.877687605849817 -1 3.91773048629671 586 612 492 609 260 435 462 479 304 448 699 514 M18736 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 93/149 Gene Ontology MF GO:0001078 0.00606914908313263 0.0166901599786147 30 416.727272727273 479 0.000553268820097854 28 1.1126032447714 1.17675113608838 1 6.69273211263493 28 707 479 781 833 58 32 243 669 599 155 515 M18644 GO_GABA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. 13/25 Gene Ontology MF GO:0050811 0.141488422038649 0.199595880860628 475 521.727272727273 480 0.0137729199527677 248 1.03632171775937 1.22969985686745 1 2.43901797450745 367 739 480 663 493 472 474 902 321 580 248 516 M18794 GO_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_ACTIVITY.html Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. 99/144 Gene Ontology MF GO:0003774 0.276748791503553 0.344630570551595 655 538.545454545455 480 0.0290248702225793 211 1.02306905461039 -1.17316459243403 -1 1.58330457891484 654 410 456 445 708 480 679 908 211 637 336 517 M18360 GO_RECEPTOR_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. 25/40 Gene Ontology MF GO:0030546 0.00069400222978728 0.00381985185213203 835 478.636363636364 481 6.31110230348928e-05 58 1.49727231524282 1.53822701708581 1 12.2717470116564 771 221 136 197 58 832 834 767 481 202 766 518 M18716 GO_PROTEIN_KINASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVITY.html Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. 14/16 Gene Ontology MF GO:0004697 0.00117595182211766 0.0055722024801883 645 479.636363636364 481 0.000106961896986545 75 0.795455317403833 0.753111319795514 1 6.06521358116821 645 371 481 376 75 695 356 581 345 597 754 519 M18447 GO_CHROMATIN_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DNA_BINDING.html Interacting selectively and non-covalently with DNA that is assembled into chromatin. 97/136 Gene Ontology MF GO:0031490 0.285155063319836 0.352250372336268 500 490.181818181818 482 0.0300562891644177 352 1.08538628178061 -1.18149329496789 -1 1.64621288466883 500 493 482 589 657 393 620 403 469 434 352 520 M18992 GO_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. 55/81 Gene Ontology MF GO:0019213 0.00354222375280813 0.0119002142335058 165 417.181818181818 482 0.000322539998424365 15 0.78799805791429 -0.795916991091918 -1 5.126198378271 165 769 713 802 519 15 104 152 482 790 78 521 M18075 GO_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_BINDING.html Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. 721/914 Gene Ontology MF GO:0019900 0.203740772229649 0.268647315305221 235 465.818181818182 483 0.0225254744812961 228 0.968648905856193 0.993995313566329 1 1.85366521894638 232 280 818 228 806 260 318 540 568 591 483 522 M19114 GO_CELL_ADHESION_MOLECULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MOLECULE_BINDING.html Interacting selectively and non-covalently with a cell adhesion molecule. 218/272 Gene Ontology MF GO:0050839 3.76441417545147e-11 2.48451335579797e-09 485 394.727272727273 483 3.42219470501444e-12 11 1.31545878847925 1.31998365993327 1 38.4199904938935 131 485 11 488 421 589 483 388 690 23 633 523 M18617 GO_ENZYME_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_INHIBITOR_ACTIVITY.html Binds to and stops, prevents or reduces the activity of an enzyme. 301/494 Gene Ontology MF GO:0004857 8.02918244826934e-07 1.45469893768645e-05 355 441.363636363636 484 7.29925943511279e-08 44 1.25964554877623 1.26018427705352 1 20.6704923865181 354 484 44 680 439 286 508 668 674 66 652 524 M18239 GO_ANDROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an androgen receptor. 55/64 Gene Ontology MF GO:0050681 0.120206002169574 0.174638908812399 220 509.454545454545 485 0.0115749876593981 217 0.732093843377014 0.803496443832591 1 1.86012566305416 217 648 734 485 907 414 319 589 241 831 219 525 M19019 GO_NEUROTROPHIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neurotrophin receptor. 19/21 Gene Ontology MF GO:0005165 0.281972060791847 0.349772962044217 840 585.272727272727 485 0.0296644556444384 318 1.08896669238926 0.764639696156182 1 1.66306021328758 839 530 318 469 485 706 898 400 422 458 913 526 M18639 GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. 9/11 Gene Ontology MF GO:0051766 0.0343158713882197 0.0619294241459278 625 549.545454545455 486 0.00348575931176158 99 0.550852503933657 0.526117856330858 1 2.23597736364395 364 622 872 623 379 367 99 447 883 903 486 527 M18178 GO_CIS_TRANS_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_TRANS_ISOMERASE_ACTIVITY.html Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. 36/44 Gene Ontology MF GO:0016859 0.337844315617101 0.409669485079005 615 508.545454545455 487 0.0367840921133538 327 0.830848602880353 -0.790467248683784 -1 1.06939916067352 351 426 626 611 487 327 387 615 518 791 455 528 M18553 GO_ION_CHANNEL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_CHANNEL_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. 122/168 Gene Ontology MF GO:0044325 0.0446815118257636 0.0765968774155947 830 549.636363636364 488 0.0041468777329277 147 1.05997143086046 -1.10112451358379 -1 3.9926426044945 826 407 147 425 745 830 784 333 702 359 488 529 M18642 GO_ORGANIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BINDING.html Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage. 172/287 Gene Ontology MF GO:0043177 1.11542339836138e-05 0.000147517563129024 690 376.909090909091 488 1.0140264124698e-06 54 1.29019388796815 -1.36656602791472 -1 16.763789820894 687 488 54 506 173 204 503 215 746 74 496 530 M18817 GO_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_A2_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. 20/33 Gene Ontology MF GO:0004623 0.000684984839191804 0.00381985185213203 480 481.181818181818 488 6.22907460776734e-05 29 1.16178971911995 1.0117840129033 1 9.51667194660392 480 726 343 816 688 425 580 29 682 488 36 531 M18109 GO_LIGAND_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 74/161 Gene Ontology MF GO:0022834 6.15145512015082e-07 1.15998867979987e-05 895 451.090909090909 489 5.59223349106334e-08 42 1.45265773887468 -1.45690039916881 -1 24.3265807534724 895 178 42 224 489 908 694 658 261 56 557 532 M18248 GO_METALLOENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 78/124 Gene Ontology MF GO:0004222 0.000734868841173058 0.00399422828967003 630 517.545454545455 489 6.68285841104225e-05 74 1.37956705791985 -1.15160471236222 -1 11.2142838620325 626 307 74 489 462 736 822 458 712 150 857 533 M18714 GO_STEROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a steroid hormone receptor. 101/118 Gene Ontology MF GO:0035258 0.236168114538013 0.303926654363683 305 517.090909090909 489 0.0241941107304149 301 0.824843349046355 0.864588017842718 1 1.42474728165668 301 492 723 590 613 465 489 377 478 798 362 534 M18402 GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 38/46 Gene Ontology MF GO:0008138 0.349204827813987 0.420684825163134 680 487.272727272727 490 0.0382982796080862 201 1.12904797910771 -1.08003354809676 -1 1.41773729648938 678 201 505 309 490 729 878 637 222 330 381 535 M18557 GO_SUMO_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. 16/17 Gene Ontology MF GO:0019789 0.013371546417491 0.029277983151094 610 471.818181818182 490 0.00122304697305571 91 0.740072352119695 0.640698381843755 1 3.83018079158697 606 368 619 391 200 330 91 490 587 736 772 536 M19031 GO_DEATH_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_ACTIVITY.html Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. 20/23 Gene Ontology MF GO:0005035 0.00119843976807959 0.00561065302978915 625 449.090909090909 490 0.000109008464626493 76 1.13273073205379 -0.960907434249888 -1 8.63568036531903 621 593 272 490 76 455 502 884 533 369 145 537 M17892 GO_PROTEIN_COMPLEX_SCAFFOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SCAFFOLD.html Functions to provide a physical support for the assembly of a multiprotein complex. 74/90 Gene Ontology MF GO:0032947 0.0622465945604668 0.100905005919073 835 559.545454545455 491 0.00582553434237752 245 1.09268413044681 -1.13419777293916 -1 3.6723794122529 835 644 463 470 779 491 851 245 552 432 393 538 M18111 GO_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with an identical protein to form a homodimer. 729/1017 Gene Ontology MF GO:0042803 0.284518231546826 0.351934198057921 920 601.727272727273 491 0.0329256663547443 204 1.123430261929 -1.12661905154505 -1 1.70625296936638 918 482 825 442 470 550 918 845 474 204 491 539 M18629 GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. 11/22 Gene Ontology MF GO:0015106 0.0010364889188014 0.00514764412153346 495 494.454545454545 492 9.42706875939466e-05 38 1.58283421663809 1.35386199699353 1 12.2778928810041 492 896 323 776 537 396 528 38 784 393 276 540 M18249 GO_PHOSPHATIDYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BINDING.html Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. 13/28 Gene Ontology MF GO:0031210 0.0210233583657421 0.0415965377514898 700 494.545454545455 494 0.00192972623858003 231 0.894343878885368 0.930234482236535 1 4.17038626777683 700 461 454 294 231 667 561 494 737 577 264 541 M19020 GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. 90/118 Gene Ontology MF GO:0019783 0.0230688940725985 0.0447807943762205 75 458.727272727273 495 0.0021194911874631 74 0.774317832095254 0.807887169265372 1 3.5231933688959 74 496 733 567 236 376 209 361 726 773 495 542 M19091 GO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_BINDING.html Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. 342/380 Gene Ontology MF GO:0051020 0.337423996035781 0.409669485079005 820 535.363636363636 495 0.0367285240582827 124 0.998732390239855 -1.02393713082785 -1 1.29038800921657 817 149 686 124 486 808 858 792 262 495 412 543 M18561 GO_LRR_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LRR_DOMAIN_BINDING.html Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. 21/25 Gene Ontology MF GO:0030275 0.104924400995415 0.155868402764894 395 483 497 0.0100264058030398 156 0.866895835010811 0.96209659974599 1 2.35250054905968 394 664 561 474 734 290 156 529 394 497 620 544 M18384 GO_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any phosphatase. 212/251 Gene Ontology MF GO:0019902 0.276038740363819 0.344210251141928 405 522.818181818182 498 0.0289382494294468 397 0.970795671607709 1.10783671399615 1 1.50291389717933 404 487 615 483 475 540 550 397 585 498 717 545 M18704 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 31/38 Gene Ontology MF GO:0097472 0.0663150305080821 0.106713375150191 560 397.454545454545 498 0.00621842049595099 125 1.01827812463802 -1.21270751330793 -1 3.33659591396118 274 333 510 556 498 200 125 555 590 558 173 546 M18470 GO_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 63/81 Gene Ontology MF GO:0003777 0.248383209799034 0.314823163037459 790 527.363636363636 499 0.0256231612236498 151 1.11897105873738 -1.21695074146611 -1 1.88330577730118 623 188 361 271 921 790 787 890 151 499 320 547 M18498 GO_CALMODULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_BINDING.html Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. 160/244 Gene Ontology MF GO:0005516 0.0906517799272538 0.139139941283692 295 453.090909090909 499 0.00860162683386872 171 1.06728862500702 0.968593221863844 1 3.0806473917157 295 295 171 499 598 567 434 534 698 289 604 548 M18772 GO_RETINOIC_ACID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. 35/135 Gene Ontology MF GO:0042974 0.0687911390170933 0.109591400778956 275 534.818181818182 499 0.00645829917487907 273 0.784908444555529 0.964051093100035 1 2.53554098047795 273 654 690 636 318 484 488 435 666 740 499 549 M18023 GO_CYTOSKELETAL_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. 15/18 Gene Ontology MF GO:0008093 0.122693021700296 0.177972295213616 735 507.454545454545 500 0.0118293237093305 222 0.778188164703675 -0.891003264334797 -1 1.95706832235064 733 367 523 372 500 607 910 438 298 612 222 550 M18746 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 14/23 Gene Ontology MF GO:0016638 0.00470307525317347 0.0145826897111822 875 511.272727272727 500 0.000428469045456127 128 1.66296459283677 1.47994030056762 1 10.346472346265 712 247 198 500 128 824 873 661 364 245 872 551 M18977 GO_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 51/126 Gene Ontology MF GO:0005267 3.18161370498473e-09 1.08881891237255e-07 595 425.363636363636 500 2.89237609962358e-10 23 1.58616560107867 -1.69620125782114 -1 37.487128875458 594 417 23 547 867 500 693 145 629 39 225 552 M17932 GO_NARROW_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NARROW_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. 8/17 Gene Ontology MF GO:0022842 0.035021317411856 0.0628343636670969 510 505.272727272727 501 0.00355858003943474 273 1.453632934968 1.30082571435309 1 5.90913391045075 510 476 806 657 273 586 501 323 330 460 636 553 M17974 GO_PROTEIN_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any protein phosphatase. 166/199 Gene Ontology MF GO:0019903 0.15559574367585 0.216848366751863 565 493.090909090909 501 0.0152573116457428 316 0.954902418140683 1.14360699774103 1 2.12871835576213 316 564 564 536 411 464 414 324 684 501 646 554 M18281 GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within. 10/13 Gene Ontology MF GO:0044213 0.0391019380278863 0.0679138923642235 470 578.272727272727 503 0.00361952010491387 276 0.439808442804228 -0.439808442804228 -1 1.720502626314 467 689 660 722 276 355 496 503 903 884 406 555 M18966 GO_PROTEIN_DOMAIN_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DOMAIN_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a specific domain of a protein. 704/931 Gene Ontology MF GO:0019904 0.165568801854381 0.227996382881442 210 502.272727272727 504 0.0179376684984435 206 1.05152322867844 1.05377249589722 1 2.26881054546415 206 696 902 461 402 228 232 682 504 638 574 556 M19004 GO_RIBONUCLEASE_P_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_P_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. 10/11 Gene Ontology MF GO:0004526 0.00275078437569051 0.00992861235600795 365 569.454545454545 506 0.000250384533614025 104 0.582020404678912 -0.582020404678912 -1 3.93540467037893 361 904 654 855 104 305 365 401 893 916 506 557 M17908 GO_CYTOSKELETAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). 802/1066 Gene Ontology MF GO:0008092 0.0536471026084291 0.0898024713221788 815 570.545454545455 507 0.00549879973441644 116 1.06876718666707 -1.11377530467569 -1 3.77522962836482 815 278 804 399 499 744 808 880 426 116 507 558 M18774 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. 15/15 Gene Ontology MF GO:0016307 0.00291220929324227 0.0103098903714784 695 472.454545454545 507 0.000265097403247518 62 0.943690180008369 -1.23794742441959 -1 6.34350481823469 693 109 507 465 908 874 720 77 166 616 62 559 M18028 GO_MIRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIRNA_BINDING.html Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. 15/25 Gene Ontology MF GO:0035198 0.193689798099366 0.259000540439673 895 561.090909090909 509 0.0193812433692147 154 1.02759513977007 1.02759513977007 1 2.02337400113039 154 894 575 903 477 443 225 485 894 613 509 560 M18042 GO_PROTEASOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_BINDING.html Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. 18/20 Gene Ontology MF GO:0070628 0.0355080706748339 0.0634612326954478 345 485.181818181818 509 0.00328131507999632 159 1.01295560451223 -0.822621213394964 -1 4.09555724823148 345 601 509 616 725 159 256 204 902 655 365 561 M18832 GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 22/25 Gene Ontology MF GO:0005086 0.000251085999915129 0.00180086618024421 600 411.545454545455 509 2.28286055399918e-05 36 0.920276782845187 0.830981690740035 1 8.55401463324085 754 227 600 148 36 568 399 625 62 509 599 562 M18114 GO_COLLAGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_BINDING.html Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 85/105 Gene Ontology MF GO:0005518 1.05246956727968e-08 3.03900587552007e-07 45 413.909090909091 510 9.56790520286037e-10 28 1.43164534598393 1.39809466726568 1 31.6653215759787 45 571 28 608 294 569 468 510 806 37 617 563 M18177 GO_R_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_R_SMAD_BINDING.html Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. 25/30 Gene Ontology MF GO:0070412 0.00703397896760727 0.0186216512097041 230 493.272727272727 511 0.000641506330364407 34 1.06972969160362 1.10087588678467 1 6.26110968518409 229 888 541 878 511 81 34 337 919 731 277 564 M19011 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery. 93/114 Gene Ontology MF GO:0001104 0.0237308184145188 0.0455868528378698 455 524.727272727273 512 0.00218097546296363 240 1.07327720904942 1.1303953204647 1 4.8646021280874 455 570 512 300 240 407 463 866 539 639 781 565 M18703 GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 37/96 Gene Ontology MF GO:0005249 7.00055199530306e-09 2.08661614311614e-07 580 414 513 6.36413819779938e-10 27 1.6728208531477 -1.83750730492124 -1 37.9314913328759 577 425 27 513 648 542 836 44 707 50 185 566 M18068 GO_PROTEIN_KINASE_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_BINDING.html Interacting selectively and non-covalently with any subunit of protein kinase A. 41/48 Gene Ontology MF GO:0051018 0.385461683285732 0.45603917459157 385 556.545454545455 515 0.0432969053615788 383 1.11853932745934 1.24882896463739 1 1.27117948924236 383 777 440 888 510 422 413 515 680 526 568 567 M19184 GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. 75/108 Gene Ontology MF GO:0000980 0.24274306344217 0.310415393186134 515 542.363636363636 515 0.0249607138964422 268 1.10991037801598 -1.162882397731 -1 1.89094286173525 515 765 356 834 852 268 607 492 541 381 355 568 M17972 GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 113/188 Gene Ontology MF GO:0072509 0.383768516989893 0.455201681256304 520 532.545454545455 516 0.0430575782703437 251 1.06859400424173 -1.10711288887008 -1 1.21623228555732 516 491 251 645 508 424 558 750 687 377 651 569 M18046 GO_PROTEIN_DIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DIMERIZATION_ACTIVITY.html The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. 1032/1514 Gene Ontology MF GO:0046983 0.018157345602493 0.0373661187899856 875 545.727272727273 516 0.00183074346141698 85 1.13840512689078 -1.1810207632933 -1 5.49517799348873 872 275 815 301 516 603 849 797 431 85 459 570 M18271 GO_DIPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a dipeptide. 10/14 Gene Ontology MF GO:0016805 0.0110949358861595 0.0256293018970284 715 524.272727272727 517 0.00101375341926568 184 1.29313926796079 -1.21715474044231 -1 6.9645396518027 715 471 261 450 184 713 704 561 336 517 855 571 M18552 GO_MODIFIED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a modified amino acid. 73/101 Gene Ontology MF GO:0072341 0.113025087854633 0.165770128853462 445 589.454545454545 521 0.0108442795872903 182 1.11740655641229 1.10095669070978 1 2.93781177055537 441 501 182 521 923 885 804 822 708 218 479 572 M19100 GO_CARBON_OXYGEN_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_OXYGEN_LYASE_ACTIVITY.html Catalysis of the breakage of a carbon-oxygen bond. 65/77 Gene Ontology MF GO:0016835 0.00403161505307727 0.0130252178637881 625 431.909090909091 521 0.00036718383718943 120 0.997000250093017 -0.903969502772031 -1 6.35942424975099 624 185 521 221 120 387 629 759 161 575 569 573 M18132 GO_GTPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. 18/20 Gene Ontology MF GO:0005095 0.00736355899622041 0.0191181340071765 525 505 523 0.00067166558844084 154 1.08181080034941 0.897103808832616 1 6.29010761067249 523 449 386 549 154 608 793 624 255 439 775 574 M19098 GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS.html Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 44/44 Gene Ontology MF GO:0016875 0.234031981578265 0.30201892594737 395 533.909090909091 524 0.0239463401088739 267 0.648266352328467 -0.680484318081006 -1 1.12057358538691 392 649 762 621 571 267 331 524 476 837 443 575 M18500 GO_MAP_KINASE_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_KINASE_ACTIVITY.html Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. 22/25 Gene Ontology MF GO:0004709 0.0452526191726218 0.0774322594731529 490 490 525 0.00420101423744006 205 0.947612375767856 1.1624956088897 1 3.55168096227738 486 525 585 528 903 338 348 222 205 608 642 576 M17891 GO_BETA_2_MICROGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_2_MICROGLOBULIN_BINDING.html Interacting selectively and non-covalently with beta-2-microglobulin. 24/41 Gene Ontology MF GO:0030881 0.254801465772815 0.321634637123062 130 566.454545454545 526 0.0263825190154334 128 0.738465202158415 -0.749502180752813 -1 1.21132150883993 128 877 526 853 453 270 417 535 917 788 467 577 M18082 GO_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. 161/349 Gene Ontology MF GO:0022836 1.24764958657325e-13 1.44103527249211e-11 890 504.181818181818 526 1.13422689688483e-14 6 1.49022524262035 -1.50387570444196 -1 54.8476105170538 887 489 6 403 579 626 853 690 526 27 460 578 M17992 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. 10/10 Gene Ontology MF GO:0052629 0.0161838346492755 0.0343766970481163 670 493.090909090909 527 0.00148219348409294 10 1.32390516208567 -1.7004574150203 -1 6.55739080886261 668 554 513 527 213 877 877 208 10 666 311 579 M18061 GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. 65/89 Gene Ontology MF GO:0005546 0.025258991982683 0.0484218020580895 830 473.363636363636 527 0.00232306804336688 97 1.14857191001243 -1.12322530894673 -1 5.10536479586078 830 183 127 143 902 619 837 662 280 97 527 580 M18495 GO_GLYCOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BINDING.html Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. 22/28 Gene Ontology MF GO:0051861 0.0261164395134727 0.0494707584180619 385 568.909090909091 527 0.0024028839179213 191 0.949566416465551 -0.906693134358323 -1 4.18656997767986 762 527 191 384 248 599 860 384 911 507 885 581 M19060 GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. 6/11 Gene Ontology MF GO:0008331 0.0229977341755825 0.0447366450068173 425 596.090909090909 527 0.00232392627016486 243 0.815774311658819 -0.866168603619446 -1 3.71430885384954 423 388 911 427 243 822 527 819 452 918 627 582 M18603 GO_SPECTRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECTRIN_BINDING.html Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. 29/40 Gene Ontology MF GO:0030507 0.128240479026278 0.184183712645692 500 509.090909090909 530 0.0123990065802665 190 1.03210940934795 1.09259426661261 1 2.55134626230215 496 513 556 459 693 723 569 308 190 530 563 583 M18005 GO_CORE_PROMOTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. 190/242 Gene Ontology MF GO:0001047 0.275158969329458 0.343576875216783 400 477.636363636364 532 0.0288310311775978 233 1.09456623232335 1.15774913499247 1 1.70059336804933 233 561 532 586 699 400 280 396 411 574 582 584 M19071 GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 316/384 Gene Ontology MF GO:0003713 0.45641066793451 0.525839722158962 490 605.363636363636 532 0.0539072369072917 364 0.916447111524494 -0.911522808721054 -1 0.844607148842708 488 557 763 480 532 445 364 813 484 842 891 585 M17958 GO_SIGNAL_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. 39/50 Gene Ontology MF GO:0005048 0.00986647219788544 0.0236181873337983 410 506.818181818182 533 0.000901000071889888 172 0.944812853299093 -0.905039186009636 -1 5.19588674240376 406 716 706 533 172 541 495 230 598 712 466 586 M18627 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. 19/22 Gene Ontology MF GO:0016864 0.0174650084882403 0.0363460987457973 415 488.363636363636 533 0.00160047433663778 34 1.03683755324568 -0.60130802447733 -1 5.04506686461235 414 533 501 385 218 565 633 614 34 763 712 587 M18819 GO_TITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TITIN_BINDING.html Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. 16/28 Gene Ontology MF GO:0031432 0.00340819318848007 0.0116205553732678 810 506.454545454545 534 0.000310316778965576 79 0.874307926706934 -0.93596441410409 -1 5.72099982808278 806 534 344 477 144 741 590 79 710 516 630 588 M19021 GO_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. 369/493 Gene Ontology MF GO:0005543 0.313601273427223 0.383798114763913 900 543.454545454545 534 0.0336302756270072 115 0.979619505821027 -0.937440722866442 -1 1.35949019900414 897 285 391 115 474 686 857 849 534 326 564 589 M17886 GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 14/19 Gene Ontology MF GO:0070008 0.531324048264773 0.601646348770404 770 598.727272727273 535 0.0665752037873739 250 0.844562235093716 -0.626542834052198 -1 0.608684528862918 766 250 357 508 831 676 535 901 837 472 453 590 M18764 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES.html Catalysis of the transfer of a phosphate group from one position to another within a single molecule. 10/10 Gene Ontology MF GO:0016868 0.464052326238707 0.532651365769646 820 560.818181818182 535 0.0551241201653827 185 1.02009198472391 -0.894933223749384 -1 0.923505433836977 820 384 478 317 535 605 650 752 185 520 923 591 M18880 GO_DRUG_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORTER_ACTIVITY.html Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 23/30 Gene Ontology MF GO:0090484 0.00355460944637187 0.0119002142335058 290 482.636363636364 535 0.000323669615110126 115 1.06852134031184 1.10464939254552 1 6.95973658961271 287 662 262 646 115 250 212 802 822 716 535 592 M18088 GO_ACTIN_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BINDING.html Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. 133/170 Gene Ontology MF GO:0051015 0.297844462997202 0.366455770718261 320 545.090909090909 536 0.0316343110115824 2 0.929726179773744 -0.96183391179777 -1 1.35242435410816 879 2 536 320 465 753 755 863 386 319 718 593 M18091 GO_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. 564/710 Gene Ontology MF GO:0004672 0.41764334677006 0.490298324364204 430 536.545454545455 536 0.0526315789473684 93 1.0370778404646 1.07936100215727 1 1.06602880938953 429 144 822 93 859 688 536 704 447 352 828 594 M18401 GO_FATTY_ACID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORTER_ACTIVITY.html Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 7/20 Gene Ontology MF GO:0015245 0.0466233629665556 0.0793369933353543 540 576.909090909091 536 0.00476314421868714 194 1.52623469198347 -1.81812659011213 -1 5.6804839298492 462 910 854 557 296 536 194 815 766 420 536 595 M18882 GO_HYALURONIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONIC_ACID_BINDING.html Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. 14/24 Gene Ontology MF GO:0005540 0.0800719808181345 0.124347076094044 680 495.909090909091 536 0.00755854868032733 210 1.7588460557661 2.13802151043979 1 5.38411068452461 532 536 210 548 426 679 690 268 641 246 679 596 M18261 GO_VITAMIN_D_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. 19/22 Gene Ontology MF GO:0042809 0.500695506970231 0.571163763506782 495 574.727272727273 537 0.0611878977488181 374 0.786026068851324 0.937887606279281 1 0.625097355081059 491 668 677 851 552 374 491 537 479 760 442 597 M18417 GO_CARBOHYDRATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. 17/20 Gene Ontology MF GO:0019200 0.0196877959069742 0.0398063969760266 755 540.818181818182 537 0.00180602012912384 202 0.999061625199091 -0.878406656996213 -1 4.72635776064787 752 728 558 512 226 739 887 423 202 537 385 598 M18310 GO_TOXIC_SUBSTANCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIC_SUBSTANCE_BINDING.html Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems. 10/17 Gene Ontology MF GO:0015643 0.144863823642203 0.20373542320456 445 533.909090909091 539 0.0141260550855379 193 1.42749095112621 1.70388328346992 1 3.32558409850296 442 687 302 600 656 539 193 697 879 518 360 599 M18823 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. 13/20 Gene Ontology MF GO:0016641 0.00446301380383206 0.0139318403876379 895 529.454545454545 539 0.000406553951049939 126 1.66296459283677 1.47994030056762 1 10.4584683396024 578 539 178 501 126 891 817 716 366 217 895 600 M18182 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS.html Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. 42/47 Gene Ontology MF GO:0016706 0.16305975322368 0.225212573959163 255 502.181818181818 540 0.0160518285598095 147 1.26302909673779 -1.25576632914868 -1 2.75293197212005 254 859 546 789 795 368 202 638 147 540 386 601 M18797 GO_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. 547/803 Gene Ontology MF GO:0008134 0.199187572741562 0.265583430322082 205 517.454545454545 540 0.0219679644079511 205 0.998879682261765 1.04454806301442 1 1.92917409724165 205 629 883 672 540 256 304 574 499 685 445 602 M18392 GO_ENZYME_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of an enzyme. 462/550 Gene Ontology MF GO:0008047 0.448293696940057 0.517779219965766 545 498.181818181818 541 0.0526315789473684 62 1.05714524235809 1.05597126606312 1 1.00208869966573 541 283 326 62 870 691 644 647 307 226 883 603 M18634 GO_3_5_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_DNA_HELICASE_ACTIVITY.html Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. 13/13 Gene Ontology MF GO:0043138 0.19232941544991 0.257554173732923 415 536.909090909091 542 0.019230952148722 224 0.596015421631627 -0.599298393492691 -1 1.1683097747414 411 542 661 524 686 310 224 552 639 901 456 604 M18728 GO_METALLOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 131/200 Gene Ontology MF GO:0008237 0.0121979823710583 0.0274283450262351 475 547.727272727273 543 0.00111510402071824 112 1.29005666963776 -1.08117800774641 -1 6.81878785782115 471 490 112 543 469 875 773 642 675 161 814 605 M18197 GO_PHOSPHATASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVATOR_ACTIVITY.html Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 11/11 Gene Ontology MF GO:0019211 0.43119990772354 0.501799388836966 425 475.363636363636 544 0.05 117 0.810021671360102 -0.500543014258011 -1 0.799618717152611 501 117 424 151 617 580 544 610 425 676 584 606 M19186 GO_PHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 78/92 Gene Ontology MF GO:0019208 0.0232031138236291 0.0448528811151323 735 527.090909090909 544 0.00213195541787318 180 0.930533256156663 -0.855565105635274 -1 4.23667046411007 631 180 544 233 239 532 733 837 419 718 732 607 M18891 GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. 36/52 Gene Ontology MF GO:0001102 0.613347051226087 0.681988778980631 545 569.272727272727 545 0.0827583709749073 388 1.53747353019484 1.58451007508856 1 0.843724111182393 544 782 393 388 567 497 451 549 649 545 897 608 M19033 GO_MISFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with a misfolded protein. 18/19 Gene Ontology MF GO:0051787 4.15621033445167e-05 0.000486118778358651 440 509.636363636364 545 3.77844441372149e-06 8 0.688340813915929 0.676899665741283 1 7.72167792586413 583 599 553 298 8 440 475 436 914 755 545 609 M18141 GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. 9/14 Gene Ontology MF GO:0015172 0.0498656382253197 0.0839268665213031 665 561.454545454545 549 0.00510212680272505 298 1.16355102761789 1.42436131891423 1 4.22832274419238 664 386 829 421 298 641 672 505 549 492 719 610 M18375 GO_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOXYGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. 69/89 Gene Ontology MF GO:0051213 0.68618940391 0.691427490962748 550 560 549 0.1 145 1.40914853119059 -1.52781189016411 -1 0.74270804446018 547 767 418 771 669 549 530 620 145 379 765 611 M19084 GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING.html Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. 313/461 Gene Ontology MF GO:0001159 0.484812844606152 0.55510169568288 265 573.454545454545 549 0.0585115372474246 262 1.11943491239336 1.16070377171327 1 0.947636773951544 262 831 520 825 808 486 358 609 589 471 549 612 M19073 GO_RECEPTOR_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_REGULATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. 34/55 Gene Ontology MF GO:0030545 0.0618053004498695 0.100542425379717 790 550.818181818182 550 0.00578301206443029 158 1.50928023642741 -1.43162954238444 -1 5.08977329199937 789 427 160 550 373 702 738 788 497 158 877 613 M18777 GO_MICROTUBULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BINDING.html Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. 197/252 Gene Ontology MF GO:0008017 0.021909058089362 0.0431641144447131 650 548.909090909091 552 0.00201184857164632 68 1.06436474797698 -1.00941403128731 -1 4.9097408214716 649 700 552 402 794 509 785 803 285 491 68 614 M18798 GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. 15/16 Gene Ontology MF GO:0004549 0.362914350761431 0.434932373675178 390 641.181818181818 552 0.0401578839339003 390 0.553957165524362 -0.55306727920254 -1 0.656026087948813 390 893 688 857 497 412 486 530 841 907 552 615 M19092 GO_PRE_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MRNA_BINDING.html Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. 36/40 Gene Ontology MF GO:0036002 0.224302876450525 0.291089687977928 110 576.454545454545 553 0.0228257448039719 106 0.64290426998665 0.64290426998665 1 1.14605687258774 106 868 752 839 427 415 333 375 850 823 553 616 M17964 GO_CARBOHYDRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BINDING.html Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. 183/328 Gene Ontology MF GO:0030246 5.2714133719081e-10 2.56357155560162e-08 910 427 554 4.79219397561016e-11 1 1.36167141017499 -1.39051013737151 -1 35.0828925210532 910 160 16 1 40 637 888 868 614 9 554 617 M18156 GO_MHC_CLASS_II_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_RECEPTOR_ACTIVITY.html Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 7/10 Gene Ontology MF GO:0032395 0.643929941801086 0.691427490962748 440 611 554 0.0981100540268952 418 2.81982755980506 -3.16863210140882 -1 1.5105128855136 439 911 830 843 597 583 512 554 524 418 510 618 M18452 GO_CYCLIC_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 26/43 Gene Ontology MF GO:0030551 0.0388300234557234 0.0675686283862305 635 490.818181818182 554 0.00359389109465313 143 1.43083137906018 -1.4150722468334 -1 5.66275186835324 633 216 143 319 664 784 637 390 554 159 900 619 M18545 GO_INTERMEDIATE_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BINDING.html Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. 24/27 Gene Ontology MF GO:0019215 0.150018151294227 0.210025411811917 670 545.181818181818 555 0.0146677543653108 224 1.8048840704268 -2.24623716562891 -1 4.13025130542547 670 224 268 607 375 865 555 793 741 356 543 620 M18062 GO_PRENYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRENYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). 16/16 Gene Ontology MF GO:0004659 0.0775909001624904 0.12090049199012 590 572.545454545455 556 0.00731551446515508 140 1.08035623753993 -0.904948502956652 -1 3.34257719725337 590 891 640 856 530 525 140 412 556 513 645 621 M18112 GO_POLY_PYRIMIDINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PYRIMIDINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. 21/26 Gene Ontology MF GO:0008187 0.413020136314376 0.485535122079496 205 540.727272727273 557 0.0472789832539389 203 0.802554412132882 0.64504983613982 1 0.831028094201381 203 795 651 823 557 507 334 476 348 692 562 622 M19217 GO_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 19/37 Gene Ontology MF GO:0005272 0.00130387787087173 0.0058484619062402 550 533 559 0.000118604662206557 79 2.00931588313108 -2.28059554668677 -1 15.2143105159123 559 793 79 644 878 781 547 174 688 174 546 623 M17869 GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. 19/21 Gene Ontology MF GO:0034237 0.0552144369548083 0.092090504957117 165 491.272727272727 560 0.00515008303604356 114 1.09509595264196 1.205142703123 1 3.82818925184448 161 887 584 826 774 205 114 318 560 672 303 624 M18021 GO_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 87/105 Gene Ontology MF GO:0019210 0.332953460610575 0.404801312637068 855 534.909090909091 562 0.0361394748564738 210 1.24626031818532 -1.28299106811678 -1 1.63818933018088 852 498 275 688 483 649 691 562 390 210 586 625 M18104 GO_HYDRO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDRO_LYASE_ACTIVITY.html Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. 44/52 Gene Ontology MF GO:0016836 0.000260966435535417 0.00184289310506407 715 502.454545454545 562 2.37270360731593e-05 38 1.00587648097566 1.13231770074172 1 9.31769740515007 711 320 433 217 38 720 848 612 164 562 902 626 M18549 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING.html Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. 25/27 Gene Ontology MF GO:0016922 0.00878667146168081 0.0216503584815815 645 535.727272727273 562 0.000801996582038276 166 0.685703574064292 -0.6202551532749 -1 3.85228114152653 642 523 705 632 166 562 698 269 500 733 463 627 M17889 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. 22/26 Gene Ontology MF GO:0080025 0.529421307156878 0.601646348770404 475 593.636363636364 563 0.0662313343550176 431 1.0962908142514 1.22723277896752 1 0.797339871339402 473 878 563 723 643 630 431 678 553 506 452 628 M18040 GO_S_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. 25/29 Gene Ontology MF GO:0016417 0.00161648729941888 0.00682024778384953 575 472.909090909091 564 0.000147061478555013 82 0.754883074016018 -0.836430785426483 -1 5.529580627774 571 339 646 229 82 564 689 875 136 651 420 629 M18246 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. 12/14 Gene Ontology MF GO:0004861 0.00424273007350157 0.0134514304128153 605 521.181818181818 564 0.000386448581455974 123 0.829805119221886 0.713305151199292 1 5.2494813432468 602 616 549 387 123 651 368 719 384 564 770 630 M19209 GO_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY.html Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 376/431 Gene Ontology MF GO:0016874 0.318391165777333 0.389144758172296 730 521.818181818182 564 0.0342452845605044 148 0.921124433910776 -0.931628002942928 -1 1.2580664226559 726 148 788 177 602 553 813 564 221 795 353 631 M18710 GO_KINESIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_BINDING.html Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. 49/60 Gene Ontology MF GO:0019894 0.0324713826121803 0.0593441411563719 560 576.909090909091 566 0.00299643586336969 197 1.28303615551785 1.38185030162111 1 5.32095146233963 560 772 376 698 872 763 640 197 562 340 566 632 M18662 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. 19/31 Gene Ontology MF GO:0043395 0.0096197047030426 0.023135301227543 275 510.090909090909 567 0.000878366096957206 106 1.62302692351101 1.46701012262233 1 8.99251622178054 271 603 106 375 814 806 567 683 676 172 538 633 M18682 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. 7/13 Gene Ontology MF GO:0050664 1.6753207397445e-06 2.81453884277075e-05 550 536.363636363636 567 1.67532200276065e-07 2 1.34693523148941 1.65107480718177 1 20.793313412648 550 625 873 649 2 778 715 395 325 421 567 634 M18922 GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING.html Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. 18/24 Gene Ontology MF GO:0031683 0.00519067166846539 0.0156737928812484 765 536.090909090909 567 0.000472996284192818 93 0.802582586386288 0.95970763498647 1 4.89545803849709 763 93 451 457 134 671 572 567 823 554 812 635 M17935 GO_BHLH_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BHLH_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. 30/36 Gene Ontology MF GO:0043425 0.0221044608391771 0.0434564293944674 585 514.909090909091 568 0.00202997547316163 234 0.922195045196363 1.13227467875232 1 4.24151334139041 568 432 514 581 234 510 295 583 630 702 615 636 M18225 GO_GDP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_BINDING.html Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. 69/79 Gene Ontology MF GO:0019003 0.127916643878975 0.184104328573479 575 570.090909090909 571 0.0123656606531535 180 0.870706053572443 0.799161824781688 1 2.14912082301659 398 574 735 571 868 395 180 569 466 748 767 637 M18464 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). 182/229 Gene Ontology MF GO:0016747 0.0168334878957669 0.0353503245811106 880 575.636363636364 571 0.00154215342254217 198 0.908121673344653 -0.965597072152313 -1 4.45295661456924 876 400 711 273 216 883 900 563 198 741 571 638 M17930 GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. 3/12 Gene Ontology MF GO:0043855 0.188338611294569 0.252943134936311 735 562.818181818182 572 0.0206509899228067 207 1.48615822120473 1.48615822120473 1 2.98900743513809 207 753 805 731 731 314 233 572 836 479 530 639 M18370 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. 11/13 Gene Ontology MF GO:0016671 7.84228465901366e-06 0.00011322298476451 745 510.181818181818 572 7.12937510395275e-07 5 0.836734268340778 -0.891376927847113 -1 11.1899113647926 742 550 572 292 5 710 734 553 90 678 686 640 M18842 GO_MYOSIN_V_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_V_BINDING.html Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. 18/22 Gene Ontology MF GO:0031489 0.0774446958517403 0.120876518525351 420 520.636363636364 572 0.00730121157310618 99 1.25303161396833 -1.25303161396833 -1 3.88107227288782 920 604 590 572 328 678 419 439 99 660 418 641 M18026 GO_PROTEIN_LIPID_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_BINDING.html Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. 23/37 Gene Ontology MF GO:0071814 0.0154714631934877 0.0330153163759415 445 494.090909090909 573 0.00141648631054421 131 1.47572066913983 1.41259172506043 1 7.40008129933355 443 591 139 684 208 798 641 676 573 131 551 642 M18345 GO_ION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ion A(out) + ion B(in) = ion A(in) + ion B(out) where ion A and ion B are different types of ion. 30/57 Gene Ontology MF GO:0099516 0.68618940391 0.691427490962748 550 579.909090909091 573 0.1 301 1.07089085013569 1.12099934770712 1 0.558601043668835 616 334 301 515 695 911 762 573 578 547 547 643 M18172 GO_PROTEIN_C_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_C_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 253/295 Gene Ontology MF GO:0008022 0.68618940391 0.691427490962748 465 546.636363636364 574 0.1 154 0.920610054769029 0.941516300431869 1 0.476806163430766 463 154 699 201 751 574 537 760 363 789 722 644 M18408 GO_ADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_BINDING.html Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. 45/67 Gene Ontology MF GO:0043531 0.68618940391 0.691427490962748 925 645.454545454545 574 0.1 438 0.910480952670313 -0.993682089878239 -1 0.471293092442139 922 505 438 574 771 471 839 812 650 570 548 645 M19079 GO_SODIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_BINDING.html Interacting selectively and non-covalently with sodium ions (Na+). 12/30 Gene Ontology MF GO:0031402 0.0125507713959853 0.0280634746129833 665 566.090909090909 577 0.00114754085271167 113 2.04283673373659 -2.09086805887804 -1 10.7428993877585 663 547 113 382 905 860 881 577 305 187 807 646 M18097 GO_SERINE_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 124/379 Gene Ontology MF GO:0017171 2.39791536939542e-09 8.86269520528547e-08 740 503.363636363636 580 2.17992306546278e-10 21 1.53946325573827 -1.51823325669456 -1 36.8500434217268 739 299 21 398 633 811 866 580 351 53 786 647 M18391 GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE.html The action of a molecule that contributes to the structural integrity of a muscle fiber. 39/67 Gene Ontology MF GO:0008307 0.0753111491601001 0.1183460915373 905 577.636363636364 580 0.00709272482889015 248 1.28865956702646 -1.21305304147706 -1 4.03232813026715 905 580 248 642 326 817 769 533 563 284 687 648 M19212 GO_MRNA_3_UTR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_UTR_BINDING.html Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. 54/64 Gene Ontology MF GO:0003730 0.628334456715395 0.691427490962748 440 548.636363636364 581 0.0860489494968299 158 1.19379048958021 -1.43420059136064 -1 0.625492899445488 437 577 581 290 668 675 429 816 158 596 808 649 M19183 GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. 45/53 Gene Ontology MF GO:0005547 0.537569306992046 0.606804681586363 585 552.454545454545 582 0.0677128556283033 318 0.829198655112895 0.925376123909504 1 0.58672875202858 410 318 515 334 582 797 605 495 738 698 585 650 M17895 GO_OXALATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. 6/11 Gene Ontology MF GO:0019531 0.00667847105364075 0.0179168713482886 535 613 583 0.000669862724967264 110 1.1494727381735 1.1494727381735 1 6.79506925542057 561 694 803 777 739 528 531 110 885 583 532 651 M18041 GO_ANKYRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANKYRIN_BINDING.html Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. 30/49 Gene Ontology MF GO:0030506 0.461912551674786 0.530854723566545 340 605.181818181818 584 0.0547817934089291 340 0.997752573627505 0.743782928342379 1 0.907722347579498 340 584 363 624 884 552 351 917 759 703 580 652 M18677 GO_RAL_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAL_GTPASE_BINDING.html Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. 18/21 Gene Ontology MF GO:0017160 0.001987529187282 0.00778036745187508 885 542.727272727273 586 0.000180847912718758 92 0.849093493917567 -0.980117130308762 -1 6.05775239433202 768 881 586 612 92 389 882 556 239 659 306 653 M18958 GO_MYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_BINDING.html Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. 80/108 Gene Ontology MF GO:0017022 0.153143025243303 0.213752500490652 645 559.090909090909 586 0.0149976219967151 297 1.15715769584411 -1.20110835927339 -1 2.60927916716799 871 643 329 606 377 642 845 512 586 442 297 654 M19015 GO_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. 6/13 Gene Ontology MF GO:0015116 0.0063630472404161 0.0172418054256436 535 623 586 0.000638134077179322 107 1.1494727381735 1.1494727381735 1 6.8601864263386 562 695 905 778 740 529 532 107 886 586 533 655 M17851 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. 22/27 Gene Ontology MF GO:0016814 0.612233122337757 0.681570367518178 515 603.909090909091 587 0.0825184550024207 413 1.35878625139522 -1.26296842999086 -1 0.744075385790615 511 791 413 772 810 587 422 729 619 505 484 656 M18043 GO_DNA_N_GLYCOSYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_N_GLYCOSYLASE_ACTIVITY.html Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. 15/17 Gene Ontology MF GO:0019104 0.43630759300163 0.506467607956666 350 578.181818181818 587 0.0507787079361348 350 0.726530045432664 -0.786785353404967 -1 0.704774971929824 350 803 595 709 554 354 442 587 831 725 410 657 M18015 GO_I_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_SMAD_BINDING.html Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. 17/18 Gene Ontology MF GO:0070411 0.047631494760204 0.0806071449788068 735 534 588 0.00442683018753617 117 0.868917620549698 0.995555160517989 1 3.20321290970285 409 731 576 627 288 588 559 731 117 641 607 658 M18045 GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. 13/13 Gene Ontology MF GO:0052744 0.00705365576125157 0.0186216512097041 585 446.727272727273 588 0.000643306661856531 14 1.32390516208567 -1.7004574150203 -1 7.75455963748015 584 614 588 625 148 650 598 187 14 707 199 659 M18252 GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS.html Catalysis of the hydrolysis of any ester bond. 622/826 Gene Ontology MF GO:0016788 0.439801984933354 0.509244403607042 360 551.454545454545 588 0.056299562111048 143 1.09914341626005 -1.00346203892796 -1 1.06981038569475 888 143 839 162 588 358 768 738 356 535 691 660 M19150 GO_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOMERASE_ACTIVITY.html Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. 142/174 Gene Ontology MF GO:0016853 0.68618940391 0.691427490962748 450 581.909090909091 588 0.1 296 1.04222625282963 -0.903003183612964 -1 0.542999467313051 448 565 637 407 842 473 588 836 296 687 622 661 M18079 GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of metal ions from one side of a membrane to the other. 247/461 Gene Ontology MF GO:0046873 7.10373957937388e-15 9.37693624477353e-13 675 526.363636363636 589 6.45794507215809e-16 5 1.37639489913952 -1.41549507359571 -1 56.2033654875934 673 290 5 443 589 745 696 922 530 17 880 662 M18429 GO_RAB_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GTPASE_BINDING.html Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. 122/135 Gene Ontology MF GO:0017137 0.0621372157101618 0.100904722875553 770 481.363636363636 589 0.00581499310485412 3 0.958024908314908 0.881261838352421 1 3.21681979420159 767 3 589 117 308 743 756 809 123 452 628 663 M18057 GO_C2H2_ZINC_FINGER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_C2H2_ZINC_FINGER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. 16/22 Gene Ontology MF GO:0070742 0.530175946460946 0.601646348770404 595 631.090909090909 591 0.0663675636629028 471 1.26885732177853 1.35042911227641 1 0.926668029812453 591 806 471 784 550 731 728 536 577 512 656 664 M18518 GO_CHANNEL_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_INHIBITOR_ACTIVITY.html Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 37/62 Gene Ontology MF GO:0016248 0.68618940391 0.691427490962748 615 523.090909090909 591 0.1 203 1.15033134365519 1.07045964904331 1 0.601838941349825 615 203 409 338 787 765 718 591 234 481 613 665 M18194 GO_RAN_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAN_GTPASE_BINDING.html Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. 33/38 Gene Ontology MF GO:0008536 0.0255640596247422 0.0488041138290533 575 561.727272727273 593 0.00235145807942742 243 0.69785165100065 -0.635804814715271 -1 3.0843110972961 655 512 742 575 245 657 601 593 243 783 573 666 M18223 GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. 25/32 Gene Ontology MF GO:0015036 0.537849604133367 0.606804681586363 595 565.181818181818 593 0.067764242089756 152 0.780524070234763 -0.876303041744859 -1 0.550863030915026 593 522 638 458 743 625 702 496 152 732 556 667 M17965 GO_TAU_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_BINDING.html Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. 16/20 Gene Ontology MF GO:0048156 0.68618940391 0.691427490962748 785 543.818181818182 594 0.1 125 0.96953644921635 1.04253272219861 1 0.503435837332446 783 360 423 333 621 813 594 806 125 290 834 668 M18543 GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. 90/118 Gene Ontology MF GO:1902936 0.346033082004215 0.41850074315693 895 551.545454545455 594 0.0378731301961008 156 1.07577335168999 -1.04698756572528 -1 1.35795550547434 892 173 244 156 871 594 923 888 434 192 700 669 M18231 GO_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 731/917 Gene Ontology MF GO:0016301 0.596044209050341 0.665955077584662 265 580.181818181818 595 0.0866580952369572 141 1.0208805430527 1.05104033919661 1 0.58790420182899 542 141 837 264 869 780 595 777 410 262 905 670 M18655 GO_ANNEALING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANNEALING_ACTIVITY.html A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide. 15/15 Gene Ontology MF GO:0097617 0.104291868556994 0.155428526688165 905 610.636363636364 596 0.00996282667796734 349 0.604258057394975 0.604258057394975 1 1.63494664475817 431 809 656 830 349 385 405 448 904 904 596 671 M19117 GO_RECEPTOR_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INHIBITOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. 8/14 Gene Ontology MF GO:0030547 0.133491564462189 0.190055786691931 320 587 596 0.0142261812759891 309 1.56131456156059 -1.37804268025973 -1 3.79969137395752 723 819 917 780 446 381 317 317 596 309 852 672 M18465 GO_MOLECULAR_FUNCTION_REGULATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLECULAR_FUNCTION_REGULATOR.html A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators. 1191/1627 Gene Ontology MF GO:0098772 0.000801514871699137 0.00423199852257144 600 548.818181818182 597 8.01804110275275e-05 45 1.13522833797629 -1.15432746155266 -1 9.12696963739362 597 274 860 112 587 732 662 853 512 45 803 673 M18106 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a lipoprotein particle receptor. 20/30 Gene Ontology MF GO:0070325 0.68618940391 0.691427490962748 570 627.545454545455 598 0.1 397 1.34871474219526 1.58695902056464 1 0.709815122106761 566 598 397 584 772 872 780 746 445 486 657 674 M18291 GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS.html Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 30/40 Gene Ontology MF GO:0016877 0.43119990772354 0.501799388836966 820 520.181818181818 599 0.05 67 1.0766857855078 -1.10685824633661 -1 1.07084589936446 818 67 422 126 817 792 599 814 122 363 782 675 M18236 GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 11/14 Gene Ontology MF GO:0004185 0.159247606422259 0.221270358397244 565 597.636363636364 601 0.0156452380731162 312 0.938494120188679 -0.669060336881111 -1 2.06377831325949 564 551 312 601 781 664 747 327 849 391 787 676 M18888 GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. 25/27 Gene Ontology MF GO:0003887 0.0888091700020002 0.136994445879546 525 609.090909090909 601 0.00841917046456229 334 0.738394555557443 -1.04258899366343 -1 2.14076781335952 522 788 687 858 334 417 556 601 820 734 383 677 M18915 GO_IRON_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_BINDING.html Interacting selectively and non-covalently with iron (Fe) ions. 109/229 Gene Ontology MF GO:0005506 0.00379133046944883 0.0123787609673877 455 542.454545454545 602 0.000345261817996687 81 1.64319303346754 1.62125380680516 1 10.6203103476823 452 760 91 881 918 694 602 611 404 81 473 678 M18944 GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING.html Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 18/25 Gene Ontology MF GO:0090079 0.378945672868057 0.451218816662481 520 634.545454545455 602 0.0423791367547028 358 0.780576273111269 0.682702353150566 1 0.892000303667038 520 885 602 736 505 571 420 894 358 754 735 679 M18525 GO_RETINAL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_BINDING.html Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. 11/18 Gene Ontology MF GO:0016918 0.172807592755137 0.236554393638143 605 605.272727272727 603 0.0170992071235231 204 1.55633343932062 -1.8808319091191 -1 3.28506820009631 603 815 204 817 399 857 912 341 834 273 603 680 M18827 GO_SNRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_BINDING.html Interacting selectively and non-covalently with a small nuclear RNA (snRNA). 37/42 Gene Ontology MF GO:0017069 0.381466098017852 0.453052280936369 600 673.818181818182 605 0.0427330913826814 507 0.597174300531395 -0.635347447387816 -1 0.67314556169756 551 862 759 828 507 609 600 598 584 909 605 681 M18598 GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY.html Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. 15/18 Gene Ontology MF GO:0005041 0.111880246345905 0.164351904012109 895 587.454545454545 607 0.0107282813607106 220 1.35688389692552 1.61592373750454 1 3.58982665584409 894 607 220 523 672 645 826 299 485 372 919 682 M19065 GO_TBP_CLASS_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TBP_CLASS_PROTEIN_BINDING.html Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). 20/25 Gene Ontology MF GO:0017025 0.113780429401018 0.166613497252838 605 580.636363636364 607 0.0109208872456037 354 0.638206201525261 -0.450685238992855 -1 1.66274704921694 604 669 736 748 354 430 392 421 607 772 654 683 M18300 GO_AMINOACYL_TRNA_EDITING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOACYL_TRNA_EDITING_ACTIVITY.html The hydrolysis of an incorrectly aminoacylated tRNA. 11/11 Gene Ontology MF GO:0002161 0.0611982346430299 0.0999066586751937 430 576.636363636364 608 0.00572454603624751 286 0.531083940163657 -0.539875589879865 -1 1.78022742023407 428 742 666 628 306 394 286 585 815 885 608 684 M19168 GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. 8/61 Gene Ontology MF GO:0008391 0.103164262581767 0.154245596481478 840 603.090909090909 608 0.0108291933083262 266 1.12445885378119 -1.01109919859077 -1 3.07601881156064 837 266 919 367 748 923 608 301 557 467 641 685 M18766 GO_SINGLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with single-stranded DNA. 96/108 Gene Ontology MF GO:0003697 0.444454245347002 0.513987137297409 340 602.090909090909 609 0.0520341069341211 337 0.773593699130036 -0.847981121903629 -1 0.735184175762932 337 841 781 805 634 372 472 461 609 829 482 686 M18427 GO_MISMATCHED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCHED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. 11/14 Gene Ontology MF GO:0030983 0.0110079007434343 0.0254919806690057 610 633.363636363636 610 0.00100576079319086 182 0.517252535422452 -0.488740949329149 -1 2.77533937244351 610 743 608 786 182 537 546 635 866 895 559 687 M18569 GO_MICROFILAMENT_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROFILAMENT_MOTOR_ACTIVITY.html Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 15/31 Gene Ontology MF GO:0000146 0.0187375625756563 0.038304220840501 900 547.272727272727 610 0.00171809827496732 165 0.613234409296548 0.548042460867418 1 2.92651240418966 320 674 614 717 287 610 349 165 896 899 489 688 M19194 GO_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. 147/319 Gene Ontology MF GO:0005261 2.57072697633497e-11 1.82719363548732e-09 815 553.363636363636 611 2.33702452396819e-12 10 1.45647797592837 -1.59990434054116 -1 43.2014495721985 812 403 10 448 611 890 832 838 618 47 578 689 M18721 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY.html Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. 18/21 Gene Ontology MF GO:0030228 0.0200354221814808 0.0404208080691884 905 571.181818181818 614 0.00183820416161808 168 1.39462380160731 1.62449961687959 1 6.57578010903228 614 671 227 697 904 901 760 168 420 328 593 690 M18535 GO_LIGASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_REGULATOR_ACTIVITY.html Modulates the activity of a ligase. 15/20 Gene Ontology MF GO:0055103 0.0171356112921221 0.0357410944332298 555 514.363636363636 615 0.00157005026178603 49 0.96115692531119 -1.07642397158536 -1 4.69884503400599 552 673 373 686 622 615 724 212 658 494 49 691 M18896 GO_K63_LINKED_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_K63_LINKED_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. 18/19 Gene Ontology MF GO:0070530 0.68618940391 0.691427490962748 600 636.909090909091 616 0.1 488 0.9239290731102 -0.800713034484984 -1 0.47861263981427 596 602 639 526 616 634 551 831 488 661 862 692 M19203 GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. 12/13 Gene Ontology MF GO:0046030 0.00019016509039445 0.0014890893519023 845 506 617 1.72892300002564e-05 30 0.729055786668424 0.62065512564716 1 6.97599739103561 841 378 485 40 30 905 748 617 42 696 784 693 M18115 GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING.html Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. 689/977 Gene Ontology MF GO:0001067 0.395272765428354 0.465857187826274 830 624.090909090909 620 0.0490537880084556 282 1.08047394429097 1.08761087108837 1 1.19314677965931 282 828 826 900 854 428 340 538 575 620 674 694 M19113 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_.html Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. 17/19 Gene Ontology MF GO:0042800 0.114925629075077 0.16802417921736 285 576.090909090909 622 0.0110371480850608 238 0.456913477893194 0.456913477893194 1 1.1778422702659 285 796 753 835 356 349 238 622 705 920 478 695 M18571 GO_FERROUS_IRON_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERROUS_IRON_BINDING.html Interacting selectively and non-covalently with ferrous iron, Fe(II). 23/29 Gene Ontology MF GO:0008198 0.0266725643616319 0.0503996921679915 675 558 623 0.00245468520114387 186 1.64280385523975 -1.52331494135887 -1 7.21563872371496 758 879 476 794 671 363 510 186 203 623 675 696 M18739 GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. 9/18 Gene Ontology MF GO:0015101 0.18051889028887 0.244830286005315 780 595.181818181818 623 0.0197115297220684 178 1.10822037238661 -1.41171210084562 -1 2.27600554149594 779 623 877 473 407 533 806 640 178 648 583 697 M19027 GO_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. 749/1167 Gene Ontology MF GO:0043565 0.368524983464787 0.441084306634019 300 623.545454545455 623 0.0449290900555899 298 1.08717700433897 1.09822453346927 1 1.28832584692566 298 827 907 889 846 462 360 445 559 643 623 698 M19047 GO_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEAMINASE_ACTIVITY.html Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). 23/28 Gene Ontology MF GO:0019239 0.0574252036617955 0.0949210879847925 505 596.363636363636 624 0.00536193715777815 135 1.30005219021854 -1.19464207627737 -1 4.4911537390945 502 792 473 783 850 457 411 907 624 626 135 699 M18165 GO_CALCIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_BINDING.html Interacting selectively and non-covalently with calcium ions (Ca2+). 528/853 Gene Ontology MF GO:0005509 1.57102470989145e-06 2.68819783692538e-05 640 626.818181818182 625 1.57102582054595e-07 15 1.30649776042143 -1.27769994418922 -1 20.2568390540878 636 483 832 486 625 870 613 912 617 15 806 700 M18421 GO_ADENOSINE_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOSINE_DEAMINASE_ACTIVITY.html Catalysis of the reaction: adenosine + H2O = inosine + NH3. 8/10 Gene Ontology MF GO:0004000 0.00215751024879808 0.00810381898329033 360 529.454545454545 627 0.000215960779821881 14 1.24972264958513 -1.24972264958513 -1 8.85235585957405 358 820 856 713 791 348 215 774 308 627 14 701 M18595 GO_RAGE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAGE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. 5/18 Gene Ontology MF GO:0050786 0.139861079106571 0.198208032353485 655 591.909090909091 627 0.0149532102812944 204 1.15022042305133 -0.432711042921473 -1 2.72158735474956 653 627 869 715 376 408 204 808 912 555 384 702 M18084 GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. 7/7 Gene Ontology MF GO:0004523 0.6513215599 0.691427490962748 455 673.909090909091 630 0.1 451 0.578926546339519 -0.468849873770413 -1 0.290834552200419 451 749 820 630 618 501 465 886 811 873 609 703 M18497 GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 87/96 Gene Ontology MF GO:0004702 0.17554322944553 0.239235905616032 910 584 630 0.0173951600343766 181 0.884387765135958 -0.831465450734706 -1 1.8415626620677 909 306 630 245 388 913 799 605 181 646 802 704 M18893 GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. 15/18 Gene Ontology MF GO:0042975 0.0832787881838195 0.128893802817168 635 541.090909090909 631 0.00787355579671269 144 0.702109167816548 -0.660275608130133 -1 2.09749940143541 300 800 643 633 430 432 144 804 408 727 631 705 M18423 GO_14_3_3_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_14_3_3_PROTEIN_BINDING.html Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. 38/67 Gene Ontology MF GO:0071889 0.00247946046186117 0.00903177023653679 860 560.818181818182 632 0.000225659936277599 103 0.927102769381724 -0.862107235296521 -1 6.41257340293447 858 424 437 468 103 692 794 715 378 632 668 706 M19172 GO_MACROMOLECULAR_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_BINDING.html Interacting selectively and non-covalently with any macromolecular complex. 1499/1921 Gene Ontology MF GO:0044877 0.495511275704649 0.566649033107792 630 663.727272727273 632 0.0661327476594762 399 1.09165654303709 1.09860464196843 1 0.890366886805464 504 754 920 775 632 759 627 488 626 399 817 707 M18539 GO_CAMP_RESPONSE_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_RESPONSE_ELEMENT_BINDING.html Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. 14/16 Gene Ontology MF GO:0035497 0.0756375539033112 0.118657215291442 755 630 633 0.00712459222215834 327 0.917367572354108 -0.714247743937983 -1 2.85997951813303 751 610 522 615 327 633 812 706 536 720 698 708 M18632 GO_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BINDING.html Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. 50/96 Gene Ontology MF GO:0042562 0.00601733099974101 0.0165978511777989 100 517.636363636364 634 0.000548532054980279 89 1.26606724939059 1.08395124771181 1 7.62958050237529 796 194 99 100 207 897 919 921 634 89 838 709 M19154 GO_DNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with a DNA polymerase. 14/16 Gene Ontology MF GO:0070182 0.119550560924417 0.173960186290018 470 589.363636363636 634 0.0115080675269529 171 0.569009602852679 -0.580632343521141 -1 1.44361956353428 470 613 694 634 651 469 171 669 765 922 425 710 M18508 GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the rate of NTP hydrolysis by a NTPase. 334/380 Gene Ontology MF GO:0060589 0.68618940391 0.691427490962748 635 558.181818181818 635 0.1 167 1.03377745337463 0.96563407373896 1 0.5384009519945 635 288 475 167 727 768 712 825 322 395 826 711 M18822 GO_GTPASE_ACTIVATING_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVATING_PROTEIN_BINDING.html Interacting selectively and non-covalently with a GTPase activating protein. 31/36 Gene Ontology MF GO:0032794 0.00380619423269607 0.0123835333486309 650 560.818181818182 635 0.000346617752622863 118 0.850560946359031 0.79127255028012 1 5.48517073312963 553 331 435 650 118 818 648 532 689 635 760 712 M19160 GO_EXODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. 18/19 Gene Ontology MF GO:0004529 0.0127630564826487 0.028348711995114 390 582.636363636364 635 0.00116706426885496 195 1.05802479620362 -1.14433976444558 -1 5.53647698856834 386 797 604 782 195 636 635 833 338 756 447 713 M19206 GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS.html Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. 12/13 Gene Ontology MF GO:0016801 0.68618940391 0.691427490962748 595 545.454545454545 635 0.1 81 1.88341143790098 -2.01559987454463 -1 1.00084001375865 728 684 366 660 592 635 666 692 81 301 595 714 M18523 GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING.html Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. 9/17 Gene Ontology MF GO:0033612 0.6513215599 0.691427490962748 640 583.363636363636 636 0.1 40 2.13371787162039 -2.15801740561064 -1 1.13707688101069 747 818 866 555 636 655 638 595 40 338 529 715 M18975 GO_DOUBLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with double-stranded RNA. 109/150 Gene Ontology MF GO:0003725 0.0381273466924582 0.0669765557867517 185 529.818181818182 636 0.00352769157804343 183 1.0408636299189 0.962022132318335 1 4.12628941504704 183 837 636 899 719 311 251 210 657 663 462 716 M18581 GO_IDENTICAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IDENTICAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with an identical protein or proteins. 1258/1724 Gene Ontology MF GO:0042802 0.374307295429694 0.447425538133296 640 611.545454545455 638 0.0458072573001599 206 1.11569072449663 -1.10839943520264 -1 1.29926102628457 638 273 868 592 539 863 686 743 487 206 832 717 M19090 GO_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. 391/476 Gene Ontology MF GO:0016887 0.244935956863638 0.312166653988968 460 608.363636363636 638 0.0252177392881993 318 0.941083485062591 -0.954015367943342 -1 1.59181417490839 456 830 777 638 819 328 581 452 647 846 318 718 M18676 GO_VITAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BINDING.html Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 68/91 Gene Ontology MF GO:0019842 0.263930620440296 0.331347681096241 905 565.272727272727 639 0.0274729164354529 166 1.27370377508905 -1.36566400581386 -1 2.05097559351359 902 573 219 639 829 419 656 654 263 166 898 719 M18787 GO_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 71/84 Gene Ontology MF GO:0019209 0.43119990772354 0.501799388836966 870 566.454545454545 639 0.05 22 0.993957753456011 1.06039730156229 1 0.986702252608487 869 22 368 202 639 756 908 784 423 524 736 720 M18589 GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY.html Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 14/17 Gene Ontology MF GO:0003906 0.27872565542756 0.346625175794166 585 630.545454545455 640 0.0292664403370672 337 0.841363744984352 -0.841363744984352 -1 1.29062550413818 581 680 629 719 802 470 513 844 640 721 337 721 M17897 GO_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. 98/152 Gene Ontology MF GO:0016597 0.0367315574132188 0.0650190786394908 850 565 641 0.00339632389513936 141 1.31522233970727 1.15387968760719 1 5.27786734770385 850 641 141 529 660 446 757 484 678 176 853 722 M18858 GO_GTP_RHO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_RHO_BINDING.html Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. 20/21 Gene Ontology MF GO:0017049 0.68618940391 0.691427490962748 910 602 642 0.1 352 0.891634067916603 -0.939915878465551 -1 0.461035103871282 906 352 535 514 653 770 642 687 398 489 676 723 M18283 GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES.html Catalysis of the hydrolysis of any acid anhydride. 741/890 Gene Ontology MF GO:0016817 0.282013914202318 0.349772962044217 535 634.363636363636 643 0.0325877045872046 296 0.963816628818327 -0.976195444329999 -1 1.46914362601294 534 826 841 818 704 296 643 597 495 851 373 724 M18301 GO_FOLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_BINDING.html Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 11/12 Gene Ontology MF GO:0005542 0.432003181684528 0.502101811165414 900 634.363636363636 643 0.050122043286661 111 1.78441522323638 1.41674159945499 1 1.78909996824502 643 899 372 767 899 838 840 456 111 542 611 725 M18050 GO_ATPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the ATP hydrolysis activity of an ATPase. 21/24 Gene Ontology MF GO:0001671 0.0165557854597502 0.034944277476582 645 505.363636363636 644 0.00151651838790374 106 0.787979128714709 -0.874346822138828 -1 3.87405775111671 379 884 645 897 644 106 168 160 865 691 120 726 M18380 GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. 18/25 Gene Ontology MF GO:0008139 0.677402395918891 0.691427490962748 545 647.090909090909 645 0.0977376596102284 383 0.955230440978488 -0.801344565660357 -1 0.49564935851028 545 736 684 631 580 761 615 645 383 656 882 727 M18389 GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group (CH3-) to a protein. 74/84 Gene Ontology MF GO:0008276 0.159639289164706 0.221481536318601 705 603.454545454545 645 0.0156869362694283 270 0.77356257510164 -0.909645277607966 -1 1.69573602493777 702 645 769 670 409 627 819 444 475 808 270 728 M18718 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase. 325/400 Gene Ontology MF GO:0044389 0.68618940391 0.691427490962748 845 681.272727272727 645 0.1 545 0.917374511778069 -0.871332654225365 -1 0.475045121038057 843 630 691 565 715 545 856 621 645 744 639 729 M18972 GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. 12/12 Gene Ontology MF GO:0004535 0.0278696483962878 0.0523405591832722 580 604.818181818182 646 0.00256628117638031 253 0.502337738188194 0.502337738188194 1 2.16156043942518 413 741 700 720 253 646 325 576 788 915 576 730 M19024 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. 46/65 Gene Ontology MF GO:0016860 0.68618940391 0.691427490962748 650 645.636363636364 646 0.1 348 0.890078891758156 -0.67407091001297 -1 0.460188652085351 348 650 613 705 834 517 574 827 646 750 638 731 M18625 GO_DEATH_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). 21/23 Gene Ontology MF GO:0005123 0.663297808722397 0.691427490962748 680 645.727272727273 647 0.0942207687903986 503 0.743507225599997 -0.816069201358321 -1 0.380412577900686 677 595 625 570 647 707 767 717 514 781 503 732 M18406 GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 928/1422 Gene Ontology MF GO:0001071 0.377717086926598 0.45089091001353 260 624.818181818182 649 0.0463285363285726 260 1.06859587058646 1.06719660123464 1 1.23123230099973 260 919 855 882 698 451 332 483 579 765 649 733 M19219 GO_STRUCTURE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. 134/179 Gene Ontology MF GO:0043566 0.0670846691219086 0.107428482268013 680 634.727272727273 652 0.00629291899382709 251 1.02515837329977 -1.10503369181279 -1 3.34920508084459 680 703 634 755 873 584 801 251 537 652 512 734 M18952 GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. 64/83 Gene Ontology MF GO:0070491 0.45550592831203 0.525452531535974 885 582.090909090909 653 0.0537641943109471 186 0.862765938976347 -0.822001821890912 -1 0.794650164413906 883 186 674 254 531 690 868 916 246 502 653 735 M17986 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 18/29 Gene Ontology MF GO:0016894 0.140941474243771 0.199390781032127 770 604.727272727273 654 0.0137158170448705 246 0.796094715866429 -0.796137643653926 -1 1.86921839577218 770 730 598 703 762 495 433 519 742 654 246 736 M18838 GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY.html Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. 22/31 Gene Ontology MF GO:0030159 0.68618940391 0.691427490962748 785 651 654 0.1 307 1.02848365125893 -1.14223419011397 -1 0.535519639655149 785 594 307 690 645 802 654 698 864 510 612 737 M18731 GO_GUANYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. 337/417 Gene Ontology MF GO:0019001 0.418133203029213 0.490298324364204 765 631.545454545455 655 0.0480364386198881 397 0.982681238469173 -0.963741171318289 -1 1.00884099805659 765 397 668 542 523 815 828 655 407 552 795 738 M17994 GO_CYCLIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_BINDING.html Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. 18/22 Gene Ontology MF GO:0030332 0.0930273474398731 0.141666740193912 660 606.818181818182 656 0.00883735361561264 339 0.691038441081295 0.786778900394459 1 1.96773163841447 656 667 594 664 339 506 441 487 814 751 756 739 M18885 GO_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_BINDING.html Interacting selectively and non-covalently with any enzyme. 1910/2452 Gene Ontology MF GO:0019899 0.6513215599 0.691427490962748 650 643 657 0.1 304 1.0087295152285 -0.982359648011045 -1 0.524767852063969 647 392 893 304 667 848 657 791 511 573 790 740 M19049 GO_THYROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a thyroid hormone receptor. 38/42 Gene Ontology MF GO:0046966 0.111055774570651 0.163400534559365 275 562.636363636364 657 0.0106448279709724 165 0.681081524835588 0.828772384357077 1 1.79564422308837 275 780 737 753 788 165 185 657 653 825 371 741 M17973 GO_PROTEIN_HETERODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETERODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. 388/584 Gene Ontology MF GO:0046982 0.0257880642276436 0.0490291591488533 660 533.181818181818 658 0.00237230941703083 129 1.11621663858869 1.04721367401851 1 4.94034010585469 658 284 129 211 860 795 665 861 428 154 820 742 M18867 GO_NF_KAPPAB_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NF_KAPPAB_BINDING.html Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. 37/42 Gene Ontology MF GO:0051059 0.68618940391 0.691427490962748 655 675.636363636364 658 0.1 536 0.743479436964124 0.718255340056244 1 0.380397453092904 536 651 724 724 702 622 651 747 623 794 658 743 M17893 GO_HEAT_SHOCK_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAT_SHOCK_PROTEIN_BINDING.html Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. 108/119 Gene Ontology MF GO:0031072 0.118849241917857 0.173212459829811 560 577.636363636364 659 0.0114365134407989 189 0.905106935278197 -0.893853631247423 -1 2.31640611782102 558 758 659 747 877 189 479 304 797 686 300 744 M17918 GO_LIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of lipids into, out of or within a cell, or between cells. 97/169 Gene Ontology MF GO:0005319 1.97044517050174e-06 3.25123453132787e-05 915 475.727272727273 659 1.79131539576978e-07 10 1.37257806023372 -1.35638426079917 -1 20.8976171995878 913 10 47 65 906 858 683 724 340 28 659 745 M18666 GO_DEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. 69/77 Gene Ontology MF GO:0004536 0.0587107393785186 0.0965279771988456 355 612.636363636364 659 0.00548533571970166 303 0.801762491714087 -0.85930372691857 -1 2.74061208594209 355 848 756 866 303 378 492 871 659 836 375 746 M18923 GO_DOPAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_BINDING.html Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. 3/12 Gene Ontology MF GO:0035240 0.0374676186372076 0.0659430088014853 630 671.909090909091 659 0.00381147486108286 217 0.796855963190055 0.796855963190055 1 3.17156248759363 661 628 897 629 572 659 571 217 915 912 730 747 M18307 GO_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids. 189/224 Gene Ontology MF GO:0004518 0.68618940391 0.691427490962748 745 696.727272727273 660 0.1 460 1.00787590959344 -0.939097101618956 -1 0.524303251310961 741 923 784 879 637 460 660 607 491 850 632 748 M18637 GO_ISOPRENOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BINDING.html Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 23/53 Gene Ontology MF GO:0019840 0.152405756710979 0.21304526354152 660 549.636363636364 660 0.0149196949131017 197 1.24725777968377 -1.25111348222418 -1 2.8204326194663 660 723 197 695 797 273 404 736 802 254 505 749 M18286 GO_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. 221/269 Gene Ontology MF GO:0035091 0.68618940391 0.691427490962748 890 595.454545454545 661 0.1 127 0.944215832975233 -0.897136288049431 -1 0.489654324079583 890 292 484 127 766 661 861 899 455 410 705 750 M18323 GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. 18/19 Gene Ontology MF GO:0010485 0.0128079522255751 0.0283802106868858 800 651.727272727273 661 0.00117119372549713 196 0.655667978391408 0.655667978391408 1 3.42070590335123 565 799 739 752 196 628 497 644 798 890 661 751 M18829 GO_ENZYME_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_REGULATOR_ACTIVITY.html Binds to and modulates the activity of an enzyme. 872/1178 Gene Ontology MF GO:0030234 0.00525070999993344 0.0157521299998003 585 555.454545454545 661 0.000526315789473684 6 1.10251948912784 -1.09100792125558 -1 6.72592267452033 585 277 885 6 661 730 675 786 507 130 868 752 M18131 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol phosphate. 140/175 Gene Ontology MF GO:1901981 0.68618940391 0.691427490962748 860 592 662 0.1 169 0.990293064583838 -0.939342502034014 -1 0.514733254703635 856 169 410 335 706 689 842 911 528 404 662 753 M18397 GO_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). 1045/1327 Gene Ontology MF GO:0032403 0.0421334971190095 0.0726331181678448 665 608.909090909091 662 0.00429543417247689 102 1.11611232587633 1.15075792214969 1 4.29287261046662 662 276 853 495 578 845 776 737 583 102 791 754 M18511 GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING.html Interacting selectively and non-covalently with any part of the small ribosomal subunit. 19/22 Gene Ontology MF GO:0043024 0.0365866869359929 0.0649900736709154 800 533.909090909091 662 0.00338269901562067 95 0.874469176960622 0.958738216528201 1 3.50160942260944 190 798 662 895 801 226 95 330 800 761 315 755 M18771 GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY.html Modulation of the activity of the enzyme protein phosphatase type 2A. 20/22 Gene Ontology MF GO:0008601 0.68618940391 0.691427490962748 730 573.454545454545 664 0.1 46 0.781327494638849 -0.457655294748955 -1 0.400997406248559 620 350 664 386 714 787 730 726 46 684 601 756 M18314 GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY.html Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. 10/11 Gene Ontology MF GO:0005092 0.32289106044498 0.394123302313291 460 657.818181818182 665 0.0348266484815429 316 0.5172654399268 -0.5172654399268 -1 0.686140588324044 459 902 665 859 919 493 316 504 878 887 354 757 M18779 GO_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBULIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. 288/374 Gene Ontology MF GO:0015631 0.68618940391 0.691427490962748 790 621 665 0.1 335 1.05550215707733 -1.01729725308013 -1 0.550225280800018 787 558 555 362 915 842 743 673 335 396 665 758 M18313 GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. 9/21 Gene Ontology MF GO:0004303 0.203811437260779 0.268647315305221 395 588.636363636364 666 0.0225341495489146 261 0.285073713255501 -0.321054565751971 -1 0.528411386206642 395 745 843 795 424 261 346 666 774 886 340 759 M18980 GO_APOLIPOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOLIPOPROTEIN_BINDING.html Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex. 20/26 Gene Ontology MF GO:0034185 0.0478463989141473 0.0808228018220697 870 601.272727272727 666 0.00444725531773402 238 1.55377706156583 -1.38487953891538 -1 5.74090697011625 868 666 238 530 289 840 843 321 731 368 920 760 M18456 GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. 172/211 Gene Ontology MF GO:0004721 0.68618940391 0.691427490962748 670 638.181818181818 667 0.1 294 0.991104366450696 1.00780119047638 1 0.515174830347912 667 294 494 359 685 805 596 898 692 644 886 761 M17924 GO_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. 177/237 Gene Ontology MF GO:0042393 0.214698766362716 0.280993852859986 655 651 669 0.0217320090062442 237 0.932611853530088 0.753462930984853 1 1.72198827402088 688 563 745 669 422 654 653 828 237 832 870 762 M18809 GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING.html Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. 31/34 Gene Ontology MF GO:0001098 0.00084469037998351 0.00440957011923595 875 640.272727272727 671 7.68195339490223e-05 65 0.628538127328851 -0.630246002583584 -1 5.00436253773743 875 583 738 534 65 856 671 713 551 807 650 763 M18654 GO_GLUCURONOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. 16/36 Gene Ontology MF GO:0015020 0.0615203672119532 0.100255413234294 650 658.181818181818 672 0.00575556608793718 307 1.58174142420082 -1.32028654963779 -1 5.34197010070499 650 801 396 759 307 912 589 905 672 515 734 764 M18760 GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 624/779 Gene Ontology MF GO:0000988 0.32482406860481 0.395959682573674 380 625.181818181818 672 0.0385168110491238 377 0.969914534989775 0.958089354765913 1 1.30115136878221 377 755 881 750 491 397 393 787 529 845 672 765 M19000 GO_ANGIOTENSIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOTENSIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an angiotensin receptor. 18/21 Gene Ontology MF GO:0031701 0.530725647960809 0.601646348770404 630 668.727272727273 672 0.0664669223857016 408 1.28425332030635 -0.683519623940524 -1 0.938206399372052 628 672 408 797 603 793 706 491 871 662 725 766 M18267 GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY.html Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. 20/26 Gene Ontology MF GO:0004012 0.68618940391 0.691427490962748 850 648.818181818182 673 0.1 340 0.94232094197358 -0.818539462997221 -1 0.488622972188171 846 349 340 413 673 764 557 920 881 487 907 767 M18775 GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. 60/81 Gene Ontology MF GO:0033613 0.218325554910617 0.284933351324026 295 599.454545454545 673 0.0221435987389104 241 1.12623133067837 1.07528561149637 1 2.06139917421868 292 850 467 673 891 343 241 748 755 645 689 768 M18210 GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY.html Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 13/13 Gene Ontology MF GO:0009982 0.172540840933727 0.23653966917324 650 649.272727272727 676 0.017070396397445 339 0.283154010095678 0.276870765339145 1 0.577850820307971 531 740 676 714 649 693 520 339 648 879 753 769 M17877 GO_LONG_CHAIN_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 14/26 Gene Ontology MF GO:0036041 0.546258906292826 0.615540523676307 610 582.636363636364 677 0.0693192361936376 242 1.25270911766748 1.2936001900141 1 0.872379338718002 609 459 298 343 736 881 751 686 677 242 727 770 M18218 GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. 11/12 Gene Ontology MF GO:0052743 0.68618940391 0.691427490962748 760 609.727272727273 677 0.1 56 0.785615987655231 -0.948372012737704 -1 0.403331548623976 760 618 593 200 729 833 879 821 56 677 541 771 M18343 GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE.html The action of a molecule that contributes to the structural integrity of the nuclear pore complex. 14/14 Gene Ontology MF GO:0017056 0.574093218899379 0.644546943211453 740 674.636363636364 677 0.0746600273010239 402 0.668527582391234 -0.668527582391234 -1 0.408837047427897 740 677 653 568 697 917 661 506 402 893 707 772 M18435 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a functional group from one position to another within a single molecule. 26/27 Gene Ontology MF GO:0016866 0.623906684315719 0.69123474377425 525 666.272727272727 678 0.0850644333288372 309 0.939683444323369 -0.802638576739993 -1 0.487573875231815 803 524 672 520 678 843 824 521 309 739 896 773 M18443 GO_RNA_POLYMERASE_CORE_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_CORE_ENZYME_BINDING.html Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. 28/29 Gene Ontology MF GO:0043175 0.000242804840080556 0.00179146500373526 685 543.636363636364 679 2.20756037800967e-05 34 0.788328892923992 -0.688692935007723 -1 7.33016025007641 795 335 679 395 34 812 684 648 120 682 796 774 M19023 GO_C_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. 14/20 Gene Ontology MF GO:0016408 0.14709134850399 0.206240373319706 720 613.181818181818 679 0.0143597938548533 50 0.977448718541956 0.495992098136479 1 2.25186567669813 720 679 641 617 372 726 830 551 50 722 837 775 M19161 GO_4_IRON_4_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_IRON_4_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. 41/42 Gene Ontology MF GO:0051539 0.156307119079487 0.217511713899769 220 578.272727272727 679 0.0153327591494682 209 0.595119438544143 -0.607335354406723 -1 1.31484819172396 216 858 744 849 679 209 293 469 764 830 450 776 M18939 GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. 11/28 Gene Ontology MF GO:0030898 0.000894022584053092 0.00461495456796121 740 621.272727272727 680 8.1307827120684e-05 67 0.694159798480765 -0.908334486338236 -1 5.48275640557619 736 549 529 437 67 899 903 241 884 680 909 777 M19012 GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. 19/20 Gene Ontology MF GO:0008353 0.0125738944694536 0.0280634746129833 605 603.545454545455 680 0.00114966724831145 193 0.691263628644593 -0.864453100688401 -1 3.61917387840355 605 880 692 785 193 600 833 680 248 764 359 778 M17896 GO_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVITY.html Catalysis of the reaction: GTP + H2O = GDP + phosphate. 232/266 Gene Ontology MF GO:0003924 0.3388942333631 0.410404025724122 795 636 681 0.0369230359664412 343 0.99018289389676 -1.00616894820555 -1 1.2765177074507 792 559 681 361 488 867 717 805 343 628 755 779 M19005 GO_P53_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_P53_BINDING.html Interacting selectively and non-covalently with one of the p53 family of proteins. 81/92 Gene Ontology MF GO:0002039 0.68618940391 0.691427490962748 675 705.909090909091 682 0.1 568 0.848630716074168 0.721626625934185 1 0.437629225527309 674 764 675 831 583 682 568 606 722 768 892 780 M18741 GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the directed movement of water (H2O) from one side of a membrane to the other. 7/14 Gene Ontology MF GO:0005372 0.0930646226165635 0.141666740193912 685 648.454545454545 683 0.00972085209250976 345 1.37041496194894 -1.11459678042491 -1 3.92611026748432 683 747 878 757 345 597 543 754 890 422 517 781 M17981 GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 62/157 Gene Ontology MF GO:0022843 5.81102711885413e-09 1.78979635260707e-07 850 540.181818181818 684 5.28275194018476e-10 26 1.56199392247671 -1.73625159855773 -1 35.7703920105242 847 415 26 704 684 895 758 231 735 86 561 782 M17920 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 10/10 Gene Ontology MF GO:0016888 0.0358011663751485 0.0638615400205352 685 679.545454545455 685 0.00330885424452935 206 0.577973041259803 0.617806009802832 1 2.32106633039913 685 903 611 890 561 621 576 206 847 864 711 783 M18943 GO_METHYL_CPG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYL_CPG_BINDING.html Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. 16/19 Gene Ontology MF GO:0008327 0.380692464906208 0.452715363672248 810 722.636363636364 685 0.0426243073582427 506 0.666015355767586 0.718124982455742 1 0.754272348033466 810 678 667 671 506 827 610 685 749 913 833 784 M18318 GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. 9/11 Gene Ontology MF GO:0008568 0.102247269096288 0.153620287227594 690 672.818181818182 688 0.0107280994217721 353 0.784551171760005 -0.784551171760005 -1 2.14354907471507 753 688 844 576 353 750 796 688 543 888 522 785 M18620 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. 48/54 Gene Ontology MF GO:0004520 0.100189195968348 0.151266040971819 635 639.363636363636 688 0.00955143390866587 344 0.716999353240259 -0.756392652931844 -1 1.97322815996205 634 854 732 864 344 416 688 498 751 819 433 786 M19139 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. 103/141 Gene Ontology MF GO:0001085 0.259609208472962 0.326365862080295 765 654.818181818182 688 0.0269552383842217 417 1.0434025705199 -1.04836568827632 -1 1.69906226922861 764 759 517 744 444 866 636 417 703 665 688 787 M18103 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. 7/12 Gene Ontology MF GO:0004865 0.6513215599 0.691427490962748 755 616 690 0.1 201 1.4793073416482 -1.51963157988183 -1 0.780894104661849 778 690 824 462 755 612 524 762 201 417 751 788 M18905 GO_3_5_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. 49/52 Gene Ontology MF GO:0008408 0.194056787287837 0.259116288228268 455 601.909090909091 690 0.0194218267751101 236 0.892588414040818 -0.948338510591193 -1 1.75376455110229 453 853 771 867 690 236 473 702 341 821 414 789 M18016 GO_ENHANCER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENHANCER_BINDING.html Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. 100/142 Gene Ontology MF GO:0035326 0.618469609634291 0.686033516569129 770 627.454545454545 691 0.083869811647501 355 1.09690479726632 -1.08045104370349 -1 0.585431496263312 769 706 355 836 720 418 884 541 691 468 514 790 M18173 GO_GLYCINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_BINDING.html Interacting selectively and non-covalently with glycine, aminoethanoic acid. 7/15 Gene Ontology MF GO:0016594 0.6513215599 0.691427490962748 900 683.818181818182 691 0.1 448 0.704812972309036 -0.846724496795597 -1 0.359352057119479 900 691 833 662 703 563 448 557 719 604 842 791 M18471 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. 15/22 Gene Ontology MF GO:0016722 0.68618940391 0.691427490962748 700 618.545454545455 691 0.1 189 1.3378010342264 -1.15363379937867 -1 0.703875005579639 691 808 430 700 897 640 563 699 189 371 816 792 M18243 GO_MANGANESE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_BINDING.html Interacting selectively and non-covalently with manganese (Mn) ions. 58/69 Gene Ontology MF GO:0030145 0.68618940391 0.691427490962748 875 662.818181818182 693 0.1 324 1.17393549468956 -1.38163544116373 -1 0.614686216361026 874 709 383 693 753 662 765 870 621 324 637 793 M18199 GO_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 25/52 Gene Ontology MF GO:0005504 0.00175965677138368 0.00710009981117256 695 574.727272727273 695 0.000160096890938976 88 1.22576550891499 1.1891683192646 1 8.92126186874597 695 521 218 614 88 771 722 854 776 200 863 794 M18280 GO_POLY_PURINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PURINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. 24/29 Gene Ontology MF GO:0070717 0.68618940391 0.691427490962748 700 690.545454545455 696 0.1 328 0.655319405320951 0.598430577148952 1 0.332413682362624 328 724 696 861 812 696 591 652 671 883 682 795 M18372 GO_HSP90_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP90_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. 31/38 Gene Ontology MF GO:0051879 0.0108524660759833 0.0253865282385026 630 656.818181818182 696 0.000991488480846569 178 0.794063066292399 -0.654822760202783 -1 4.27841755627722 629 722 577 822 178 879 534 696 826 774 588 796 M18478 GO_DOUBLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA. 641/898 Gene Ontology MF GO:0003690 0.587550654259199 0.657694577678393 360 663.909090909091 696 0.0847556387586124 356 1.07858706089182 1.09596234735 1 0.64236521419597 356 829 862 902 841 570 426 544 564 713 696 797 M18636 GO_FOUR_WAY_JUNCTION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOUR_WAY_JUNCTION_DNA_BINDING.html Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. 15/18 Gene Ontology MF GO:0000400 0.68618940391 0.691427490962748 640 712.909090909091 696 0.1 560 0.411597551128133 -0.488740949329149 -1 0.199760672199458 640 804 685 827 696 711 614 565 838 902 560 798 M19057 GO_NEUROPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_BINDING.html Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). 4/38 Gene Ontology MF GO:0042923 0.00166979532211572 0.00698140668613088 700 525.545454545455 696 0.00016710513480011 58 1.57709647875743 -1.40083847163434 -1 11.5244604995682 696 751 910 883 119 352 154 58 839 305 714 799 M18355 GO_PROTEIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of proteins into, out of or within a cell, or between cells. 102/119 Gene Ontology MF GO:0008565 0.309345010639473 0.37959467441019 705 586.272727272727 697 0.0330870483133661 130 0.942726390865461 -0.843864863745274 -1 1.32269069284793 801 409 702 289 471 701 791 766 130 697 692 800 M19136 GO_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. 58/60 Gene Ontology MF GO:0003678 0.587939092167048 0.657694577678393 670 692.545454545455 697 0.077436024274464 508 0.700644069694181 0.700674082746021 1 0.408774654777339 573 768 758 793 828 697 669 508 519 838 667 801 M18729 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. 204/232 Gene Ontology MF GO:0061659 0.310060329636225 0.379967831013093 610 685.181818181818 699 0.0331781314211631 424 0.896788227371001 0.881802835154497 1 1.25575516553092 608 699 782 654 472 773 729 671 424 801 924 802 M18734 GO_ENDONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. 113/143 Gene Ontology MF GO:0004519 0.405147478923945 0.47688696882258 520 666.363636363636 699 0.0461243661760216 486 1.01740444043872 -0.986440805195074 -1 1.08696709204371 772 838 722 870 518 518 699 486 503 804 600 803 M19188 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING.html Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. 45/57 Gene Ontology MF GO:0032813 0.753442896982841 0.758367360361813 890 701.454545454545 699 0.119519434468133 506 0.89847804630693 -1.00579527738083 -1 0.342291621801177 889 506 527 563 604 614 814 847 889 699 764 804 M19052 GO_GAP_JUNCTION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION_CHANNEL_ACTIVITY.html A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. 6/19 Gene Ontology MF GO:0005243 0.00779592785919226 0.0198989981820267 870 636.181818181818 701 0.000782341308372945 164 1.52771375415644 -1.57266380223997 -1 8.80256890725915 870 822 909 689 164 598 701 772 329 233 911 805 M18457 GO_GROWTH_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_ACTIVITY.html The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 101/168 Gene Ontology MF GO:0008083 1.64881006321218e-08 4.23194582891127e-07 710 615.818181818182 705 1.49891825051758e-09 32 1.60148083398393 -1.68914235048813 -1 34.6424363048538 708 761 32 841 652 918 705 630 664 36 827 806 M18940 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 407/490 Gene Ontology MF GO:0004674 0.68618940391 0.691427490962748 705 653.636363636364 705 0.1 147 0.908649388206213 -0.900057488714068 -1 0.470296207939207 713 147 703 447 888 884 663 860 357 705 823 807 M17855 GO_BETA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_BINDING.html Interacting selectively and non-covalently with the beta subunit of the catenin complex. 103/129 Gene Ontology MF GO:0008013 0.68618940391 0.691427490962748 685 713.636363636364 706 0.1 497 0.94274417971397 -0.910139277883775 -1 0.488853332163329 681 638 497 706 793 829 726 677 813 701 789 808 M18872 GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a macromolecule from one side of the membrane to the other. 22/35 Gene Ontology MF GO:0022884 0.0049862371875879 0.0153015683887885 795 680.363636363636 706 0.000454324940148267 130 0.740205537206753 -0.553890267370901 -1 4.53933691105654 791 528 618 659 130 804 875 879 670 706 824 809 M17939 GO_METHYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 59/67 Gene Ontology MF GO:0035064 0.68618940391 0.691427490962748 710 651.363636363636 707 0.1 426 0.933216837855487 0.86082861513522 1 0.483667787434207 426 710 717 804 608 523 506 707 715 778 671 810 M18492 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein receptor. 13/20 Gene Ontology MF GO:0050750 0.68618940391 0.691427490962748 625 736.363636363636 709 0.1 601 0.844614900794692 1.05789092813722 1 0.435443496279326 625 682 601 674 818 777 802 843 867 709 702 811 M18754 GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 8/21 Gene Ontology MF GO:0005248 0.00243637337206222 0.00899821280743289 880 613.818181818182 711 0.000243904866290032 73 1.60145290638735 -1.46911405399095 -1 11.103352253862 368 907 880 790 711 760 548 73 877 464 374 812 M18031 GO_ESTROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an estrogen receptor. 50/56 Gene Ontology MF GO:0030331 0.68618940391 0.691427490962748 615 751.636363636364 712 0.1 613 0.785792594771842 -0.828370585231507 -1 0.403427672402914 613 712 695 869 890 666 676 878 697 775 797 813 M18381 GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. 18/24 Gene Ontology MF GO:0005385 0.68618940391 0.691427490962748 765 685.272727272727 712 0.1 518 0.950756992325319 -0.63498796389591 -1 0.493214548420645 761 729 518 741 650 712 562 891 571 657 746 814 M18105 GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY.html Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. 55/75 Gene Ontology MF GO:0003743 0.28987471543525 0.357602452686477 795 656.545454545455 714 0.0306402165842996 208 0.620105910012667 0.653482570748091 1 0.916324613064115 208 852 791 809 457 558 564 714 793 874 602 815 M18205 GO_SINGLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with single-stranded RNA. 96/138 Gene Ontology MF GO:0003727 0.0607107452266973 0.0994454755288813 245 606.545454545455 714 0.00567762119181679 242 0.939389424770681 0.878452207139204 1 3.17395899352976 243 843 714 915 775 483 345 242 771 813 528 816 M18903 GO_ZINC_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_BINDING.html Interacting selectively and non-covalently with zinc (Zn) ions. 1019/1372 Gene Ontology MF GO:0008270 0.180708068242018 0.244830286005315 495 682.363636363636 714 0.0197341621210217 408 1.03683026351967 1.02669813215885 1 2.12782519653983 493 825 895 813 408 749 570 674 498 714 867 817 M19122 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. 17/18 Gene Ontology MF GO:0015095 0.180174669027113 0.244825579678018 760 558.818181818182 714 0.0178982502015927 95 0.86794019445635 -1.04177928718417 -1 1.77729439915826 859 95 444 189 390 779 752 757 714 409 759 818 M18820 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. 35/45 Gene Ontology MF GO:0015932 0.68618940391 0.691427490962748 800 696.727272727273 715 0.1 545 1.02327656982265 -0.876218534406553 -1 0.532685527675426 799 581 551 770 875 715 771 545 758 602 697 819 M18999 GO_PROTEIN_N_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 125/154 Gene Ontology MF GO:0047485 0.219424280234161 0.285963377907426 785 687 715 0.0222686313364068 369 0.815685408126843 -0.894349822845261 -1 1.48195897717762 784 636 715 677 761 629 920 369 808 820 438 820 M18130 GO_ATPASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_REGULATOR_ACTIVITY.html Modulates the rate of ATP hydrolysis by an ATPase. 40/45 Gene Ontology MF GO:0060590 0.573136787919826 0.64425595138433 860 714 716 0.074471312996144 398 0.765138632745013 -0.83845176865684 -1 0.471935467943352 716 860 704 907 759 398 616 639 859 802 594 821 M18152 GO_RNA_POLYMERASE_II_CORE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_BINDING.html Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. 21/22 Gene Ontology MF GO:0000993 0.000136936253706215 0.00119367073985418 905 626.909090909091 716 1.24495252613822e-05 23 0.625877953992435 -0.687104907798212 -1 6.18944825964639 904 592 716 583 23 823 902 817 349 780 407 822 M18864 GO_TRANSLATION_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY.html Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 32/42 Gene Ontology MF GO:0045182 0.127553010903404 0.183867366731272 635 674.090909090909 717 0.0123282300815249 324 0.918057674026823 -1.13515578900361 -1 2.26906010021905 632 865 548 762 365 871 659 768 324 717 904 823 M19070 GO_RIBOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BINDING.html Interacting selectively and non-covalently with any part of a ribosome. 53/56 Gene Ontology MF GO:0043022 0.529702982583013 0.601646348770404 755 685.818181818182 717 0.0662821598366962 403 0.640861621891053 0.724295993785654 1 0.456023241554949 403 711 746 751 549 717 680 753 900 849 485 824 M18208 GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. 26/29 Gene Ontology MF GO:0005487 0.251080833328103 0.317806424650914 480 649.181818181818 718 0.0259416020102903 382 0.868286627228334 -0.605573560710988 -1 1.44387148217111 479 871 718 898 442 492 382 749 569 797 744 825 M18824 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. 63/69 Gene Ontology MF GO:0030374 0.361196366940642 0.43343564032877 685 681.363636363636 718 0.039922868373492 311 0.64438986109105 -0.545769734997599 -1 0.770358982342522 684 311 726 718 496 788 710 852 508 843 859 826 M17871 GO_MHC_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the major histocompatibility complex. 23/33 Gene Ontology MF GO:0023023 0.00633026676538533 0.0172034308565178 845 622.454545454545 721 0.000577141377407512 142 1.34231399265307 -1.3537546810914 -1 8.01956760204531 844 874 265 341 142 835 889 721 781 531 624 827 M18477 GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 34/44 Gene Ontology MF GO:0046915 0.68618940391 0.691427490962748 725 668.727272727273 721 0.1 297 1.05473852802041 -0.792268917719509 -1 0.549809652528257 721 653 455 734 728 882 852 877 297 592 565 828 M19142 GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 46/47 Gene Ontology MF GO:0016796 0.68618940391 0.691427490962748 855 723.545454545455 721 0.1 483 0.81425407182875 -0.868769157494013 -1 0.418918694403353 703 855 770 868 721 522 707 855 483 841 634 829 M18017 GO_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a substrate. 29/35 Gene Ontology MF GO:0032451 0.242889966746293 0.310415393186134 285 649.636363636364 722 0.024977911028724 255 0.555959886626589 -0.541082353722132 -1 0.935073199076306 283 872 766 876 722 467 255 626 898 868 513 830 M18244 GO_RNA_CAP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING.html Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. 18/18 Gene Ontology MF GO:0000339 0.160902084276075 0.22256515848966 805 676.727272727273 723 0.0158214927248087 380 0.64053791369627 -0.646669620048186 -1 1.39534722754293 802 735 719 587 380 591 521 742 763 881 723 831 M17901 GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING.html Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. 18/23 Gene Ontology MF GO:0001965 0.43119990772354 0.501799388836966 920 660.545454545455 724 0.05 97 0.983448784942228 -0.874157835008497 -1 0.976013458103623 919 97 338 598 700 902 807 909 724 436 836 832 M17940 GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. 36/38 Gene Ontology MF GO:0004003 0.68618940391 0.691427490962748 710 729 724 0.1 543 0.695395465642388 0.744063790206757 1 0.354226293524335 709 781 731 800 922 724 664 543 610 822 713 833 M18250 GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY.html Functions in chain elongation during polypeptide synthesis at the ribosome. 18/20 Gene Ontology MF GO:0003746 0.0298801389789047 0.0556638072913467 725 668.818181818182 724 0.00275398689715232 256 0.518114187147643 -0.558185906687277 -1 2.18316352333134 724 732 727 749 256 668 709 405 825 882 680 834 M18368 GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a protein serine/threonine kinase. 33/35 Gene Ontology MF GO:0030291 0.347876830634256 0.420180642491572 830 542.818181818182 724 0.0381200425313637 25 1.24036616917607 1.21718861706455 1 1.56210503797077 829 329 333 284 858 900 750 744 25 195 724 835 M18505 GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the class II major histocompatibility complex. 23/28 Gene Ontology MF GO:0023026 0.00633026676538533 0.0172034308565178 845 623.818181818182 725 0.000577141377407512 143 1.34231399265307 -1.3537546810914 -1 8.01956760204531 845 875 266 342 143 836 890 725 782 533 625 836 M18995 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS.html Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). 193/227 Gene Ontology MF GO:0016741 0.357318399706695 0.429425631174268 725 668.909090909091 725 0.0393944781508432 379 0.91024980176917 -0.967580024755763 -1 1.11068096698844 725 922 795 798 494 548 783 665 379 847 402 837 M19112 GO_TRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. 20/20 Gene Ontology MF GO:0008175 0.189122513112701 0.25362728899294 905 650.727272727273 725 0.0188775713155324 265 0.538562463229054 -0.538562463229054 -1 1.06555681624973 543 889 725 904 397 436 265 430 901 919 749 838 M19077 GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. 52/59 Gene Ontology MF GO:0016278 0.68618940391 0.691427490962748 815 688.090909090909 729 0.1 463 0.877989281958191 -1.16478345865033 -1 0.453608515326689 814 771 729 746 584 786 617 559 463 784 716 839 M18993 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the tumor necrosis factor receptor. 25/34 Gene Ontology MF GO:0005164 0.91410065408 0.916083518839393 730 696.272727272727 730 0.2 404 0.973458087239195 -1.11517492659372 -1 0.101587548666327 730 438 404 648 813 575 904 893 899 567 788 840 M18479 GO_TRANSITION_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_BINDING.html Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 1214/1709 Gene Ontology MF GO:0046914 0.215467073881781 0.281600532201932 495 668.363636363636 732 0.0239746052394996 429 1.11962543179231 1.09180264230698 1 2.06859666133266 495 824 863 880 429 762 573 732 492 431 871 841 M18096 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. 15/20 Gene Ontology MF GO:0030169 0.0665248061110015 0.106716876469732 920 622.090909090909 734 0.00623872055139843 124 1.59693969636408 -1.5861963212788 -1 5.24640975226421 917 802 166 605 316 849 899 734 521 124 910 842 M19149 GO_MONOCARBOXYLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BINDING.html Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). 45/99 Gene Ontology MF GO:0033293 0.000156571805331421 0.00131520316478394 810 502.272727272727 734 1.42348135909997e-05 26 1.20256937874689 -1.25599733163966 -1 11.7428506830191 807 197 109 288 26 734 772 904 767 144 777 843 M18297 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. 75/95 Gene Ontology MF GO:0004722 0.532031564073921 0.601710116529135 735 717.636363636364 735 0.0667033920664564 499 0.8051312808463 -0.849936176802528 -1 0.579007549385728 735 499 678 667 551 898 763 796 581 810 916 844 M17996 GO_RNA_POLYMERASE_III_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_III_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 19/21 Gene Ontology MF GO:0001056 0.292183648079407 0.35997025443383 645 745.181818181818 737 0.0309271699428483 459 0.493030227130129 -0.660384168726014 -1 0.718774438924088 644 890 751 911 459 624 678 728 908 867 737 845 M18547 GO_AMIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BINDING.html Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 225/369 Gene Ontology MF GO:0033218 0.185672839744403 0.250821204567001 915 659.545454545455 737 0.0184988542344881 300 1.16439307031274 -1.12568105576502 -1 2.35107900387636 737 698 300 756 393 915 847 913 588 315 793 846 M18737 GO_ANION_ANION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_ANION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). 13/29 Gene Ontology MF GO:0015301 0.183146884563606 0.247771187901569 855 722.909090909091 737 0.0182224699864138 392 0.920338574996866 0.984179984183511 1 1.86982067742436 855 737 487 711 392 796 865 627 891 710 881 847 M18087 GO_HISTONE_DEACETYLASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone deacetylase. 124/158 Gene Ontology MF GO:0042826 0.68618940391 0.691427490962748 750 740.454545454545 738 0.1 582 0.962582811031404 0.963008162254904 1 0.499651108876832 748 835 628 637 738 714 582 906 817 671 869 848 M18962 GO_MAP_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_ACTIVITY.html Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. 16/17 Gene Ontology MF GO:0004708 0.394547254712577 0.465595994066949 820 681.363636363636 738 0.0445914711244112 359 0.599673538083201 -0.591035950743725 -1 0.651906985588252 819 359 612 394 886 728 811 443 791 914 738 849 M17852 GO_5_3_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_5_3_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. 11/12 Gene Ontology MF GO:0008409 0.000690302251916478 0.00381985185213203 730 724.272727272727 739 6.2774449621753e-05 57 0.6613581542919 -0.52363641710607 -1 5.4069907233253 729 898 657 894 57 699 841 739 913 862 678 850 M19029 GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 267/338 Gene Ontology MF GO:0003714 0.20876852465398 0.274008688608349 455 673.454545454545 739 0.0210627177785914 416 0.949422659038621 0.873289715846342 1 1.78871818980527 454 921 768 875 416 442 467 823 668 835 739 851 M19204 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 873/1070 Gene Ontology MF GO:0016772 0.6513215599 0.691427490962748 700 673.909090909091 741 0.1 395 1.00114402193596 1.03901248377124 1 0.520639217304643 697 395 923 444 746 910 741 761 438 528 830 852 M18327 GO_HISTONE_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a histone. 23/27 Gene Ontology MF GO:0032452 0.68618940391 0.691427490962748 360 693.090909090909 743 0.1 360 0.555959886626589 -0.541082353722132 -1 0.278334251173236 360 794 743 806 642 590 545 775 862 891 616 853 M19225 GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a nucleotidyl group to a reactant. 128/136 Gene Ontology MF GO:0016779 0.0957128424090226 0.144981420304815 745 653.636363636364 743 0.00910451126360316 342 0.798960711502568 -0.798346760693012 -1 2.25157331580216 546 836 794 912 342 406 514 745 743 844 508 854 M18317 GO_SNAP_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNAP_RECEPTOR_ACTIVITY.html Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. 34/39 Gene Ontology MF GO:0005484 0.68618940391 0.691427490962748 915 760.636363636364 744 0.1 618 0.745075797705599 0.591783361350321 1 0.381266320837096 915 652 712 618 836 919 744 801 627 815 728 855 M19032 GO_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. 87/110 Gene Ontology MF GO:0004540 0.68618940391 0.691427490962748 845 721 744 0.1 451 1.00153583598021 -0.955992723839802 -1 0.520852473980233 744 842 730 873 843 520 609 858 451 814 647 856 M19103 GO_EXTRACELLULAR_GLUTAMATE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_GLUTAMATE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. 9/22 Gene Ontology MF GO:0005234 0.6513215599 0.691427490962748 915 688.363636363636 744 0.1 135 1.95822469622462 2.51830843085137 1 1.04155939836047 776 744 914 551 913 854 862 675 135 493 655 857 M18039 GO_ATPASE_ACTIVITY_COUPLED http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. 284/347 Gene Ontology MF GO:0042623 0.1708718790986 0.234599727023932 520 653.909090909091 745 0.01689033039099 336 0.891810437800772 -0.892843488063723 -1 1.88296493403801 517 832 779 811 799 479 687 336 745 852 356 858 M18587 GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any complex of RNA and protein. 114/123 Gene Ontology MF GO:0043021 0.68618940391 0.691427490962748 705 742.727272727273 745 0.1 509 0.751581313044843 0.862903050266178 1 0.38480714484433 509 705 789 679 912 844 745 616 810 857 704 859 M18385 GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. 8/8 Gene Ontology MF GO:0003964 0.00679320534770583 0.0180891116463406 855 681.363636363636 746 0.00068140615723436 156 0.599222826529132 -0.599222826529132 -1 3.5222141572562 601 746 852 852 156 554 437 708 873 894 822 860 M19222 GO_SNORNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_BINDING.html Interacting selectively and non-covalently with small nucleolar RNA. 28/31 Gene Ontology MF GO:0030515 0.0503104312589619 0.0845215245150559 750 625.818181818182 746 0.00468174426648983 170 1.0154571381436 -1.01958956336812 -1 3.67648875509482 907 337 673 432 295 916 746 876 170 749 783 861 M17926 GO_UBIQUITIN_LIKE_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_BINDING.html Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. 138/151 Gene Ontology MF GO:0032182 0.68618940391 0.691427490962748 775 712.727272727273 747 0.1 572 0.811477523952478 -0.666022583322445 -1 0.417407474021129 775 635 774 622 601 747 893 771 597 853 572 862 M18154 GO_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_BINDING.html Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. 174/227 Gene Ontology MF GO:0003729 0.68618940391 0.691427490962748 270 663.090909090909 748 0.1 266 0.997953939599924 0.79007972775016 1 0.518902918251999 266 924 783 754 735 566 457 850 372 839 748 863 M18668 GO_RRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_BINDING.html Interacting selectively and non-covalently with ribosomal RNA. 66/89 Gene Ontology MF GO:0019843 0.68618940391 0.691427490962748 705 739.818181818182 748 0.1 540 1.07877980869469 -1.25591347482391 -1 0.562894848602208 701 849 680 893 631 748 540 874 572 811 839 864 M18916 GO_STEROID_HYDROXYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HYDROXYLASE_ACTIVITY.html Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. 12/72 Gene Ontology MF GO:0008395 0.0176975417779471 0.0365828380376357 790 620 749 0.00162195736563208 123 1.59613920203994 -1.72759746562797 -1 7.76433243868786 788 683 123 814 837 846 749 711 816 186 267 865 M17995 GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 6/15 Gene Ontology MF GO:0001608 0.326641601224698 0.397650644969197 250 667.090909090909 750 0.038775950556434 249 0.61494102161458 0.61494102161458 1 0.812204839934864 249 750 811 887 856 503 450 428 920 866 618 866 M17888 GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 91/210 Gene Ontology MF GO:0005244 1.28354169181311e-08 3.5939167370767e-07 775 634.454545454545 751 1.16685609027423e-09 29 1.54901498472225 -1.62099649868704 -1 33.8801128457635 773 497 29 760 911 903 779 751 711 120 745 867 M18128 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 36/37 Gene Ontology MF GO:0016893 0.68618940391 0.691427490962748 730 774.818181818182 751 0.1 591 0.542273212666525 -0.504506814098371 -1 0.270884863813463 727 867 765 910 591 751 732 741 856 875 708 868 M17872 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. 25/30 Gene Ontology MF GO:0035255 0.577793795814198 0.647914402102329 540 721.636363636364 752 0.0753938393755656 397 0.989591363687535 0.859196449207567 1 0.609229662849856 540 876 533 833 861 746 397 798 872 730 752 869 M18925 GO_RETINOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_BINDING.html Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. 8/13 Gene Ontology MF GO:0019841 0.102453590172058 0.153680385258087 880 706 752 0.0107508371698584 300 1.34859602445765 -1.37804268025973 -1 3.70129738135283 880 748 898 740 501 752 895 300 869 308 875 870 M18886 GO_TRANSLATION_REPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REPRESSOR_ACTIVITY.html Antagonizes ribosome-mediated translation of mRNA into a polypeptide. 18/22 Gene Ontology MF GO:0030371 0.627243519206131 0.691427490962748 530 697.909090909091 753 0.0858053933588019 428 0.75536860074145 -0.852207884118226 -1 0.386868491025093 529 886 573 768 807 546 428 851 637 753 899 871 M18049 GO_POLY_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_BINDING.html Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. 17/22 Gene Ontology MF GO:0008143 0.68618940391 0.691427490962748 410 721.181818181818 754 0.1 408 0.671353791671022 0.604251353043542 1 0.341140883386515 408 805 647 791 820 757 754 733 652 871 695 872 M18339 GO_EXORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXORIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. 34/34 Gene Ontology MF GO:0004532 0.0458877032912006 0.078229221108984 835 729.454545454545 755 0.00426124982058157 284 0.734460501006482 -0.636720456182899 -1 2.73623001000191 832 719 755 792 284 638 742 896 632 816 918 873 M19177 GO_STRUCTURAL_MOLECULE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_MOLECULE_ACTIVITY.html The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. 611/949 Gene Ontology MF GO:0005198 0.0934847894068079 0.142072278637978 925 718.727272727273 756 0.0097667395052651 134 1.35436949063597 -1.42742035021284 -1 3.87414682583772 782 756 921 726 723 754 922 839 570 134 779 874 M18482 GO_TELOMERIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERIC_DNA_BINDING.html Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. 35/38 Gene Ontology MF GO:0042162 0.68618940391 0.691427490962748 760 735.909090909091 757 0.1 484 0.619738952092252 0.470032258775468 1 0.313047941693251 598 783 757 909 609 660 484 756 863 818 858 875 M18981 GO_LIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BINDING.html Interacting selectively and non-covalently with a lipid. 593/886 Gene Ontology MF GO:0008289 0.000913477965136221 0.00468918688769927 800 551.272727272727 757 9.13853681416596e-05 2 1.11445600097282 -1.07322714419068 -1 8.79088662077172 790 281 903 2 458 800 764 799 464 46 757 876 M18020 GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding. 18/22 Gene Ontology MF GO:0044183 0.552593310511369 0.621919876872722 780 742.545454545455 761 0.0705079504097475 501 0.581011796855643 0.670881433680547 1 0.382766931873538 777 892 622 914 610 721 579 501 922 869 761 877 M18596 GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING.html Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. 93/115 Gene Ontology MF GO:0008135 0.68618940391 0.691427490962748 420 724.818181818182 762 0.1 417 0.739583958493486 0.852370637126268 1 0.378277220802421 417 762 792 838 880 740 667 846 440 860 731 878 M19061 GO_GAMMA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_CATENIN_BINDING.html Interacting selectively and non-covalently with the gamma subunit of the catenin complex. 15/21 Gene Ontology MF GO:0045295 0.68618940391 0.691427490962748 880 715.727272727273 765 0.1 319 1.99989249690028 -2.52474589145834 -1 1.06423836248049 877 675 319 765 832 889 713 691 874 374 864 879 M18336 GO_TROPOMYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPOMYOSIN_BINDING.html Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. 9/14 Gene Ontology MF GO:0005523 0.357389946291139 0.429425631174268 650 684.454545454545 769 0.0432581936004924 335 1.66139924837002 1.42653323650526 1 2.04725147178855 646 906 845 847 509 839 859 514 460 335 769 880 M18516 GO_HMG_BOX_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HMG_BOX_DOMAIN_BINDING.html Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. 9/22 Gene Ontology MF GO:0071837 0.200569922866584 0.266382043687909 535 700.090909090909 769 0.0221369220823703 394 1.1415862080439 -0.59689274331028 -1 2.2031992646669 535 909 865 799 423 769 394 636 905 647 819 881 M19228 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. 52/59 Gene Ontology MF GO:0042054 0.604278407447569 0.673526234597773 570 705.272727272727 770 0.0808231708321212 418 0.574843377688241 -0.601798207863283 -1 0.310853958395832 569 770 776 908 646 547 418 663 842 848 771 882 M19013 GO_ENDORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. 49/63 Gene Ontology MF GO:0004521 0.0792903081671204 0.123340479371076 925 735.181818181818 773 0.00748191572042893 266 0.890580661638969 -0.659571183395773 -1 2.72490987349359 924 773 689 896 811 716 905 266 493 770 844 883 M17873 GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. 403/483 Gene Ontology MF GO:0019787 0.68618940391 0.691427490962748 815 738.181818181818 778 0.1 461 0.89373044500564 -0.904007439249516 -1 0.462176120675946 811 697 798 658 629 914 778 869 461 824 681 884 M18791 GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. 42/46 Gene Ontology MF GO:0018024 0.265312488587031 0.332630582706128 345 681.727272727273 778 0.0276390386693369 270 0.607609430599191 0.543396075817358 1 0.962247981580646 343 778 767 906 803 433 270 915 844 834 606 885 M18956 GO_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_BINDING.html Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 457/607 Gene Ontology MF GO:0003682 0.68618940391 0.691427490962748 920 731.909090909091 778 0.1 476 0.967792025227227 0.878676271859224 1 0.50248638167561 476 920 778 918 821 585 485 769 693 826 780 886 M18985 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. 13/17 Gene Ontology MF GO:0005337 0.616821958013306 0.6850282322167 925 728.363636363636 778 0.0835108485884475 441 1.34951082739011 -1.05311888348396 -1 0.728757150470769 923 540 441 732 825 869 924 517 882 581 778 887 M19034 GO_LAMININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMININ_BINDING.html Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. 32/43 Gene Ontology MF GO:0043236 0.0362738895444264 0.0645801039288054 420 622.727272727273 779 0.00335328717989236 250 1.42061529735841 1.33567908148464 1 5.71693933265578 419 866 250 886 269 791 624 883 779 252 831 888 M17928 GO_RNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. 45/48 Gene Ontology MF GO:0008173 0.25307184153405 0.319888346891194 710 721.545454545455 780 0.0261772999538004 386 0.702221968380524 -0.76090114179732 -1 1.1563191471753 710 861 780 916 502 681 498 386 855 840 908 889 M17922 GO_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. 33/35 Gene Ontology MF GO:0034061 0.0387102609574821 0.0674873228768179 865 740.727272727273 782 0.00358260510232208 275 0.71851287998197 -0.931747451879854 -1 2.83283026957174 738 864 721 863 275 876 777 841 832 782 579 890 M18164 GO_TRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_BINDING.html Interacting selectively and non-covalently with transfer RNA. 46/47 Gene Ontology MF GO:0000049 0.68618940391 0.691427490962748 775 799.181818181818 783 0.1 583 0.677310157011664 -0.638530534770395 -1 0.344382815853689 732 775 775 901 830 775 583 783 845 877 915 891 M18769 GO_RIBONUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. 1594/1976 Gene Ontology MF GO:0032553 0.6513215599 0.691427490962748 785 739.727272727273 785 0.1 393 0.975142599982558 -0.958983209999133 -1 0.506487154897007 840 393 882 727 785 785 854 889 480 792 710 892 M17983 GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. 8/28 Gene Ontology MF GO:0022835 0.600200647609379 0.669789128491626 895 602.909090909091 786 0.0876022436829528 73 1.61113304809473 -0.703957665338085 -1 0.928204764629709 893 387 809 142 570 864 786 826 73 461 821 893 M18048 GO_UNFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with an unfolded protein. 101/120 Gene Ontology MF GO:0051082 0.91410065408 0.916083518839393 790 789.545454545455 786 0.2 612 0.71752325820179 -0.631747150166021 -1 0.0684995935404066 786 840 773 913 910 620 612 718 897 854 762 894 M18691 GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. 13/13 Gene Ontology MF GO:0043142 0.234413276407348 0.302089075872231 815 700.909090909091 787 0.0239905205019872 253 0.409322293714354 -0.409322293714354 -1 0.698458533001194 434 811 648 787 815 556 253 848 910 905 743 895 M18906 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. 27/30 Gene Ontology MF GO:0031435 0.68618940391 0.691427490962748 830 744.090909090909 787 0.1 395 0.555938688870416 -0.486511977874134 -1 0.278322713651603 827 787 741 538 773 826 681 829 395 910 878 896 M19144 GO_RNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. 42/44 Gene Ontology MF GO:0034062 0.12431242719117 0.180038687656178 750 748.818181818182 787 0.0119952854439713 363 0.550395395313876 -0.577490719893951 -1 1.36771703338033 746 863 787 917 363 576 538 892 860 921 774 897 M18119 GO_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. 79/90 Gene Ontology MF GO:0008170 0.477825243250433 0.54777980739876 790 727.727272727273 790 0.0573577581195461 430 0.822097298636115 -0.895134536483986 -1 0.705587385700005 864 844 772 832 790 896 788 507 465 817 430 898 M18722 GO_RNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. 62/69 Gene Ontology MF GO:0003724 0.500646149774982 0.571163763506782 855 747.181818181818 793 0.0611794614592194 494 0.689868871304818 0.573826908616536 1 0.545658836275118 494 851 793 840 541 705 628 923 740 855 849 899 M18727 GO_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. 83/87 Gene Ontology MF GO:0008094 0.68618940391 0.691427490962748 765 800.818181818182 795 0.1 750 0.653682264720133 0.710385285280038 1 0.331522618943309 750 766 786 877 823 810 818 765 795 856 763 900 M18908 GO_POLY_A_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_RNA_BINDING.html Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. 1309/1614 Gene Ontology MF GO:0044822 0.6513215599 0.691427490962748 920 761.818181818182 795 0.1 405 0.809701382773136 -0.832578397779794 -1 0.416440755321672 405 918 896 920 689 742 578 795 661 911 865 901 M17942 GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY.html Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 94/102 Gene Ontology MF GO:0070035 0.68618940391 0.691427490962748 815 774 796 0.1 596 0.683899049496409 0.648689549889974 1 0.347969020400826 862 763 796 812 596 878 795 664 679 858 811 902 M18785 GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. 126/147 Gene Ontology MF GO:0008757 0.243650874992366 0.310957746537219 835 731.909090909091 797 0.0250670347962611 416 0.820069267798789 -0.932264376761266 -1 1.38869573531916 903 834 790 891 438 920 797 679 416 833 550 903 M19102 GO_ADENYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. 1305/1625 Gene Ontology MF GO:0030554 0.6513215599 0.691427490962748 730 756.090909090909 798 0.1 472 0.979027494211127 -0.95839968254135 -1 0.50860162639277 824 481 913 729 798 828 831 919 472 793 729 904 M18142 GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 29/30 Gene Ontology MF GO:0016891 0.201227994041299 0.266382043687909 645 746.181818181818 800 0.0202182433159823 412 0.563421429574243 -0.504506814098371 -1 1.0750841324628 641 870 748 837 412 698 800 832 828 876 666 905 M17890 GO_PROTEIN_KINASE_C_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_BINDING.html Interacting selectively and non-covalently with protein kinase C. 61/75 Gene Ontology MF GO:0005080 0.0578620930643952 0.095472453556252 880 656.272727272727 803 0.00540385699558932 302 0.894620831559084 -0.815030434646726 -1 3.07534287799203 878 312 407 430 302 855 914 867 803 548 903 906 M18612 GO_TRANSLATION_INITIATION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_BINDING.html Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. 25/32 Gene Ontology MF GO:0031369 0.68618940391 0.691427490962748 500 755.727272727273 805 0.1 497 0.570945017448504 -0.569894403417981 -1 0.286490363056593 497 883 749 872 692 592 611 859 853 900 805 907 M18422 GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME.html The action of a molecule that contributes to the structural integrity of the ribosome. 210/311 Gene Ontology MF GO:0003735 0.427441033600575 0.500577332125389 810 783.363636363636 807 0.0494309793725157 526 0.780922883876266 -0.750710112748225 -1 0.772830656907678 860 833 799 807 526 783 909 650 780 861 809 908 M18330 GO_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. 76/81 Gene Ontology MF GO:0004527 0.68618940391 0.691427490962748 915 765 812 0.1 527 1.03728329091019 -0.882201322706687 -1 0.540309110389962 912 845 764 874 893 595 790 547 527 812 856 909 M19213 GO_SEMAPHORIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_ACTIVITY.html Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 9/11 Gene Ontology MF GO:0017154 0.0919732985589636 0.140564326676456 925 733.454545454545 817 0.0096017553261371 151 0.622567387767927 -0.595819655835696 -1 1.7775301328168 557 817 924 821 770 683 151 864 851 924 706 910 M18442 GO_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 146/156 Gene Ontology MF GO:0004386 0.68618940391 0.691427490962748 825 791.454545454545 818 0.1 545 0.767683595197989 0.756752963474514 1 0.393571300218027 853 757 797 810 822 847 774 824 545 859 818 911 M18926 GO_INORGANIC_ANION_EXCHANGER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_EXCHANGER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). 7/24 Gene Ontology MF GO:0005452 0.6513215599 0.691427490962748 890 773.181818181818 821 0.1 424 2.01619569510269 -2.2697508755718 -1 1.07311187250691 886 821 899 708 782 886 906 646 701 424 846 912 M19180 GO_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_BINDING.html Interacting selectively and non-covalently with an RNA molecule or a portion thereof. 1684/2094 Gene Ontology MF GO:0003723 0.6513215599 0.691427490962748 925 790.545454545455 821 0.1 537 0.846333225174704 -0.85892195887891 -1 0.436378746432417 537 917 922 919 659 821 639 794 643 923 922 913 M18055 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY.html Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. 29/39 Gene Ontology MF GO:0061650 0.68618940391 0.691427490962748 885 819.818181818182 833 0.1 709 0.747801469411624 -0.837696440014867 -1 0.382749850320812 882 873 740 808 764 862 892 709 833 805 850 914 M18222 GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS.html The action of a molecule that contributes to the structural integrity of the lens of an eye. 6/22 Gene Ontology MF GO:0005212 0.101586338335277 0.153125247343876 570 669 836 0.0106552927684358 162 0.423931753118533 -0.105909536826799 -1 1.14913090268022 567 913 836 862 853 513 162 309 906 880 558 915 M17955 GO_DNA_SECONDARY_STRUCTURE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SECONDARY_STRUCTURE_BINDING.html Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. 23/27 Gene Ontology MF GO:0000217 0.68618940391 0.691427490962748 840 815.363636363636 838 0.1 683 0.411597551128133 -0.488740949329149 -1 0.199760672199458 838 790 707 801 683 850 761 903 857 865 914 916 M18037 GO_FMN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FMN_BINDING.html Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 11/14 Gene Ontology MF GO:0010181 0.91410065408 0.916083518839393 905 786.909090909091 841 0.2 432 0.471377762958423 -0.414374278847858 -1 0.0366772302782744 901 901 432 796 709 718 739 842 907 870 841 917 M18726 GO_GABA_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_ACTIVITY.html Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. 3/22 Gene Ontology MF GO:0016917 0.6513215599 0.691427490962748 870 821.272727272727 852 0.1 604 0.667328040838883 0.678590974625111 1 0.338949746412694 866 823 875 773 924 852 604 659 840 906 912 918 M18072 GO_RNA_POLYMERASE_I_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_I_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 12/14 Gene Ontology MF GO:0001054 0.682561910692477 0.691427490962748 905 786.090909090909 854 0.0990591559862617 522 0.660384168726014 -0.660384168726014 -1 0.33517033343797 854 905 697 905 581 725 522 910 876 872 800 919 M18459 GO_G_PROTEIN_COUPLED_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PHOTORECEPTOR_ACTIVITY.html Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 4/9 Gene Ontology MF GO:0008020 0.0368426607302393 0.0650910487853559 515 660.363636363636 859 0.0037468127178368 102 0.507225738020457 0.525262661572289 1 2.01971668433146 512 914 859 860 914 441 102 511 921 897 333 920 M18469 GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). 7/12 Gene Ontology MF GO:0008556 0.00175113227567149 0.00710009981117256 895 683 861 0.000175251371691677 60 3.93695080118019 -3.93695080118019 -1 28.7072465336915 916 912 861 892 885 893 677 60 301 605 511 921 M18319 GO_RRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. 15/16 Gene Ontology MF GO:0008649 0.91410065408 0.916083518839393 850 824.454545454545 869 0.2 641 0.560101717392276 -0.652698160071214 -1 0.0481477059221832 848 895 710 871 665 924 869 641 909 889 848 922 M18340 GO_LYSOZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOZYME_ACTIVITY.html Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 2/15 Gene Ontology MF GO:0003796 0.283305824110112 0.350904264715474 910 796.3 869 0.0363352212184588 306 0.187176111275429 -0.191240060687243 -1 0.264868927000805 780 915 846 NA 909 907 306 735 923 892 750 923 M17885 GO_OLFACTORY_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_RECEPTOR_ACTIVITY.html Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. 2/849 Gene Ontology MF GO:0004984 0.930263569600255 0.931271439123115 890 855.3 875 0.256132604206241 672 0.2310208768214 -0.401361017127289 -1 0 899 916 802 NA 857 887 844 672 924 863 889 924 M18869 GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY.html Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. 8/14 Gene Ontology MF GO:0045125 0.945363489397001 0.945363489397001 915 814.454545454545 889 0.252263991215487 465 1.03018372651955 1.03165142516796 1 0.0611132279376206 914 908 889 845 896 868 695 667 918 465 894