Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M18211 GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY.html Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 169/1410 Gene Ontology MF GO:0004930 3.55615425699107e-19 2.1905910223065e-17 10 116.727272727273 44 3.23286750635552e-20 2 2.67921744646765 2.91943906779575 1 47.6324100065352 29 254 11 116 104 2 184 44 521 9 10 2 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 70/85 Gene Ontology MF GO:0019199 4.00434895471893e-07 1.08187673513459e-06 40 114.454545454545 45 3.64031789415831e-08 4 2.56651812759883 2.61423318119335 1 16.3398784689354 30 36 76 213 323 4 36 45 337 142 17 3 M18391 GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE.html The action of a molecule that contributes to the structural integrity of a muscle fiber. 39/67 Gene Ontology MF GO:0008307 1.17715216973821e-07 8.2820001624993e-07 60 44.6363636363636 47 1.07013839338546e-08 8 3.26145134859949 3.40038383319024 1 21.1680990750943 14 60 47 72 77 19 96 10 30 58 8 4 M18754 GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 8/21 Gene Ontology MF GO:0005248 2.7984789338751e-07 9.30984999064807e-07 50 204.272727272727 50 2.79847928629195e-08 5 4.15907653158735 4.15907653158735 1 26.7685332960333 27 202 880 50 501 44 40 5 289 161 48 5 M18700 GO_CORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 34/48 Gene Ontology MF GO:0015026 3.21822165354338e-07 9.50043708585968e-07 5 89.7272727272727 52 2.92565647664905e-08 1 2.3681947094748 2.5009945959168 1 15.2198657825303 5 77 129 179 291 1 2 14 231 52 6 6 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 55/67 Gene Ontology MF GO:0004714 3.13919121054297e-07 9.47817595535048e-07 40 117.545454545455 53 2.85381059861441e-08 5 2.6723751656306 2.65968057438149 1 17.1776724943759 37 49 74 218 278 5 26 53 388 150 15 7 M17918 GO_LIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of lipids into, out of or within a cell, or between cells. 97/169 Gene Ontology MF GO:0005319 8.35707823139344e-08 8.2820001624993e-07 60 87.7272727272727 57 7.59734413531948e-09 17 2.85911916824151 -2.73308756370406 -1 18.5568049956354 50 17 57 121 28 51 161 55 253 113 59 8 M18684 GO_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. 28/59 Gene Ontology MF GO:0008146 1.83142242416457e-07 8.37618242795071e-07 55 81.8181818181818 64 1.66492961511277e-08 4 3.5233992203874 3.8293489596339 1 22.8497784736328 53 95 56 67 181 56 64 4 52 100 172 9 M18411 GO_CATION_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 53/70 Gene Ontology MF GO:0019829 7.85832091989584e-08 8.2820001624993e-07 20 197.909090909091 65 7.14392836417475e-09 18 1.91628878376748 -1.85931294974493 -1 12.4374650046846 43 396 340 418 18 18 46 61 490 282 65 10 M19008 GO_PEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 43/145 Gene Ontology MF GO:0001653 5.27976883418747e-07 1.23203488132786e-06 25 147.363636363636 65 4.79979100116086e-08 22 3.40121199313833 3.65860093942124 1 21.4491257689019 25 65 50 427 395 22 49 84 391 72 41 11 M19010 GO_FRIZZLED_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRIZZLED_BINDING.html Interacting selectively and non-covalently with the frizzled (fz) receptor. 32/44 Gene Ontology MF GO:0005109 6.56980391202175e-07 1.39595807371218e-06 75 97.6363636363636 65 5.9725507944967e-08 7 2.95650768421338 3.10901912998471 1 18.4735161874607 32 75 65 14 420 7 17 211 109 74 50 12 M18138 GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT.html The action of a molecule that contributes to the structural integrity of the extracellular matrix. 66/94 Gene Ontology MF GO:0005201 5.07380634841092e-21 3.90683088827641e-19 5 143.909090909091 70 4.61255122582809e-22 1 4.00336887932403 3.99389107589115 1 78.6449047613753 1 273 8 199 616 36 65 146 135 34 70 13 M18961 GO_CHEMOREPELLENT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOREPELLENT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. 34/41 Gene Ontology MF GO:0045499 1.60441345139326e-07 8.2820001624993e-07 5 98.0909090909091 70 1.45855778945432e-08 3 3.27776170309445 3.70872258210563 1 21.2739596902921 16 86 70 164 322 3 11 3 273 124 7 14 M17992 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. 10/10 Gene Ontology MF GO:0052629 5.85817032337349e-06 7.99549391255112e-06 15 230.545454545455 71 5.32562356599552e-07 13 1.37977303939599 -1.37977303939599 -1 7.5053259766004 70 199 497 192 668 49 14 42 13 721 71 15 M19157 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 24/56 Gene Ontology MF GO:0005245 1.25646105010026e-07 8.2820001624993e-07 40 69.2727272727273 71 1.14223738350827e-08 19 3.32797867708439 3.71476967402707 1 21.5998876007853 47 103 71 39 89 55 89 19 79 132 39 16 M18662 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. 19/31 Gene Ontology MF GO:0043395 2.50771189950742e-06 3.95413958215845e-06 40 136.272727272727 75 2.27974068906832e-07 12 3.59133149747539 3.411583196022 1 20.7071570441022 12 316 75 28 578 46 86 39 126 155 38 17 M18566 GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. 15/29 Gene Ontology MF GO:0015665 8.40440503128449e-08 8.2820001624993e-07 305 124.636363636364 77 7.6403685021348e-09 7 4.2816213661902 -4.22021362507899 -1 27.7894037010524 304 140 77 7 29 260 185 74 66 208 21 18 M18166 GO_NITRIC_OXIDE_SYNTHASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_SYNTHASE_BINDING.html Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. 32/45 Gene Ontology MF GO:0050998 4.17966295395581e-07 1.11129935559625e-06 85 93.1818181818182 79 3.79969431638904e-08 3 3.04833972693377 3.70574619212307 1 19.3695133430289 41 79 81 101 491 25 25 8 85 86 3 19 M18554 GO_FILAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMIN_BINDING.html Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. 11/17 Gene Ontology MF GO:0031005 7.91064543280584e-08 8.2820001624993e-07 220 117.636363636364 79 7.19149610659339e-09 19 3.36089526628484 3.54532378695923 1 21.8135292101109 254 158 61 71 19 217 217 79 23 137 58 20 M18041 GO_ANKYRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANKYRIN_BINDING.html Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. 30/49 Gene Ontology MF GO:0030506 2.54866110242053e-07 9.177676063928e-07 80 102.181818181818 80 2.31696490698042e-08 15 3.1976423616576 3.53266010106306 1 20.601767704913 89 80 69 80 237 166 219 15 38 101 30 21 M18439 GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. 67/148 Gene Ontology MF GO:0004867 4.0898583997181e-22 5.39861308762789e-20 30 133.181818181818 81 3.71805309065282e-23 4 3.73012082194461 3.8816833620102 1 76.6985960181463 8 30 4 158 361 27 81 278 372 20 126 22 M19060 GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. 6/11 Gene Ontology MF GO:0008331 7.73597324530356e-06 1.00818607597468e-05 75 234.636363636364 84 7.73600017581242e-07 16 3.03637263855998 3.46152117036677 1 16.1901771900902 71 209 911 99 713 84 58 41 16 350 29 23 M18099 GO_WNT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_PROTEIN_BINDING.html Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. 30/33 Gene Ontology MF GO:0017147 6.57188054182681e-07 1.39595807371218e-06 85 124 85 5.97443864090171e-08 8 2.32157421006129 2.50431757097021 1 14.5061814574465 17 85 123 338 421 8 12 83 107 102 68 24 M18745 GO_ACTIVIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_BINDING.html Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits. 15/16 Gene Ontology MF GO:0048185 3.63435601422157e-05 4.16643294930612e-05 75 256.636363636364 86 3.3040145949499e-06 42 1.89669389758359 2.02771436432091 1 8.86602257745421 72 566 392 191 801 86 72 81 77 443 42 25 M18674 GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate into, out of or within a cell, or between cells. 29/47 Gene Ontology MF GO:1901476 4.29867740129914e-07 1.12202766067808e-06 90 107.272727272727 87 3.90788931021543e-08 8 2.74413544556389 -2.4243520150408 -1 17.4243438428246 136 87 89 8 334 59 83 12 84 94 194 26 M18412 GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. 61/83 Gene Ontology MF GO:0042625 1.25544309235282e-07 8.2820001624993e-07 295 152.909090909091 88 1.14131196726857e-08 26 2.04668495761125 -2.10267114803094 -1 13.2837874550523 63 279 293 153 88 26 55 56 323 291 55 27 M19111 GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY.html Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 9/27 Gene Ontology MF GO:0005326 7.24841764731524e-08 8.2820001624993e-07 90 175.181818181818 88 7.24841788374326e-09 23 2.959841535499 3.11871729549848 1 19.210532771163 88 187 915 105 23 74 53 43 257 121 61 28 M18305 GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 8/20 Gene Ontology MF GO:0005328 1.35425525087235e-07 8.2820001624993e-07 50 157.090909090909 91 1.35425533340269e-08 1 3.22329093383116 3.11871729549848 1 20.920422975545 48 200 842 103 133 11 1 27 252 91 20 29 M18351 GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. 25/37 Gene Ontology MF GO:0051119 9.65083270521239e-07 1.84854077904815e-06 110 127.454545454545 91 8.77348812616949e-08 17 2.43709851664175 -2.16301208761762 -1 14.9108413574081 109 97 124 17 468 81 91 26 48 90 251 30 M18544 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. 78/147 Gene Ontology MF GO:0015085 7.17879466253161e-08 8.2820001624993e-07 100 90 94 6.52617717889274e-09 15 2.62900519161346 3.00340229288327 1 17.0632747882457 94 22 64 96 15 101 244 105 97 73 79 31 M18989 GO_ALPHA_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_ACTININ_BINDING.html Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. 17/31 Gene Ontology MF GO:0051393 5.62078966964947e-08 8.2820001624993e-07 5 111.545454545455 94 5.10980892114118e-09 2 2.75083877823938 3.17833531105142 1 17.8540226800809 107 124 102 94 5 176 453 2 80 80 4 32 M18133 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY.html Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. 12/13 Gene Ontology MF GO:0034595 4.88202504927689e-07 1.21672017060695e-06 65 260.272727272727 96 4.43820557513503e-08 28 1.17019119093988 -1.25100342717597 -1 7.38638019777861 64 445 513 489 349 28 63 96 96 683 37 33 M19120 GO_SEMAPHORIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with semaphorin receptors. 27/29 Gene Ontology MF GO:0030215 4.07549024289558e-08 7.38382938124611e-07 100 119.090909090909 96 3.70499119853988e-09 1 2.95709827500816 3.52313740034043 1 19.3500524384144 40 96 96 166 308 32 32 1 382 111 46 34 M18800 GO_SOLUTE_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). 60/113 Gene Ontology MF GO:0015294 1.27069882128889e-07 8.2820001624993e-07 35 141.545454545455 100 1.1551808133484e-08 20 2.610173625004 -2.58120391512256 -1 16.9410505148842 408 34 45 20 92 155 211 100 194 32 266 35 M19199 GO_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 159/222 Gene Ontology MF GO:0019838 1.59821033550423e-10 3.69186587501478e-09 30 157 101 1.45291848692758e-11 19 2.71869489594923 2.98259876190996 1 24.4660642195581 19 381 30 167 427 57 110 30 321 84 101 36 M18014 GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. 15/15 Gene Ontology MF GO:0010314 1.84191841891278e-05 2.20172395740673e-05 70 259.363636363636 105 1.67448530935554e-06 5 3.0148332400898 3.0148332400898 1 14.9839328564689 49 513 346 326 768 66 5 90 105 519 66 37 M18045 GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. 13/13 Gene Ontology MF GO:0052744 2.64961108655987e-06 4.12856769642718e-06 55 270.909090909091 108 2.40874025243077e-07 32 1.1900464052335 -1.28293886999242 -1 6.83784421258029 108 335 549 358 585 76 50 52 32 781 54 38 M18089 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 7/11 Gene Ontology MF GO:0016813 4.23513175714444e-07 1.11129935559625e-06 95 194.818181818182 109 4.23513256428e-08 5 4.45063266315187 -4.71397014002643 -1 28.2798508227057 139 203 821 11 344 109 94 47 5 279 91 39 M18293 GO_MANNOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSE_BINDING.html Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. 10/23 Gene Ontology MF GO:0005537 1.3651424047096e-07 8.2820001624993e-07 10 224.818181818182 110 1.24103862674485e-08 6 1.36322950894048 -1.36322950894048 -1 8.84789280426905 31 193 477 234 110 16 6 24 830 543 9 40 M18092 GO_HEPARIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARIN_BINDING.html Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 151/236 Gene Ontology MF GO:0008201 1.60446847726713e-25 3.70632218248706e-23 10 188.727272727273 113 1.45860770660647e-26 2 3.71400002671288 3.77172425434784 1 88.9049370029056 9 464 2 257 562 104 126 113 308 23 108 41 M19052 GO_GAP_JUNCTION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION_CHANNEL_ACTIVITY.html A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. 6/19 Gene Ontology MF GO:0005243 2.72583015286527e-07 9.30984999064807e-07 100 207.181818181818 115 2.72583048722208e-08 24 3.81977274146306 3.97508673854445 1 24.5847153985665 98 210 909 174 270 90 24 115 57 227 105 42 M17911 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS.html Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). 44/77 Gene Ontology MF GO:0016782 1.48629560175414e-07 8.2820001624993e-07 370 215.454545454545 117 1.35117791106057e-08 48 2.70206602893666 3.4133339880485 1 17.5374683557914 368 59 92 69 132 457 536 48 62 117 430 43 M18659 GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). 23/28 Gene Ontology MF GO:0036442 1.40820327831462e-07 8.2820001624993e-07 10 241.272727272727 119 1.2801848804115e-08 9 1.35772026392672 -1.35772026392672 -1 8.81213563745744 11 416 550 501 119 9 9 18 379 597 45 44 M18012 GO_STEROID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BINDING.html Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. 79/140 Gene Ontology MF GO:0005496 1.46532532140672e-07 8.2820001624993e-07 240 154.090909090909 120 1.33211401727795e-08 29 2.55791658402645 -2.81463269011975 -1 16.6018817673251 236 29 86 131 128 96 220 120 496 93 60 45 M17981 GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 62/157 Gene Ontology MF GO:0022843 7.07075974669894e-12 1.86668057312852e-10 125 103.545454545455 121 6.42796340611062e-13 23 3.40571124759783 3.58891821605465 1 35.3595819080059 142 35 26 23 130 88 210 121 202 40 122 46 M18473 GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. 20/55 Gene Ontology MF GO:0005231 9.98922038180493e-08 8.2820001624993e-07 50 387.818181818182 123 9.08110985033723e-09 44 2.64115431389245 -2.4283504932729 -1 17.1421273698352 818 113 87 44 50 881 793 485 123 47 825 47 M18537 GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. 245/394 Gene Ontology MF GO:0022804 4.08940886320306e-12 1.18081680924988e-10 245 150.363636363636 123 3.71764442110059e-13 10 2.3476562549946 -2.37425059618569 -1 24.8726750556433 243 246 36 10 123 97 259 118 338 15 169 48 M18158 GO_EXTRACELLULAR_MATRIX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_BINDING.html Interacting selectively and non-covalently with a component of the extracellular matrix. 75/88 Gene Ontology MF GO:0050840 1.43755746438383e-13 6.03774135041209e-12 5 190.818181818182 124 1.30687042216721e-14 2 3.33447523481845 3.45899462391273 1 39.9227754103369 2 271 16 259 737 85 124 177 281 44 103 49 M18258 GO_GLYCOSAMINOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSAMINOGLYCAN_BINDING.html Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 186/306 Gene Ontology MF GO:0005539 1.56941635882115e-29 4.83380238516913e-27 10 177.909090909091 124 1.42674214438287e-30 1 3.5608251444697 3.78536656218194 1 100 10 376 1 256 535 124 130 111 278 18 118 50 M18396 GO_CARBON_CARBON_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_CARBON_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 44/54 Gene Ontology MF GO:0016830 6.97840829448512e-08 8.2820001624993e-07 120 262.909090909091 124 6.34400774167318e-09 11 1.61266346682081 -1.59885550603387 -1 10.4668172881355 117 282 484 491 11 50 33 98 746 456 124 51 M18777 GO_MICROTUBULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BINDING.html Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. 197/252 Gene Ontology MF GO:0008017 2.63779922694257e-07 9.23961214138929e-07 115 162.090909090909 128 2.3979995847406e-08 32 2.0068039467039 2.40633348215067 1 12.9231781796182 113 251 206 262 245 61 301 69 128 115 32 52 M18366 GO_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTININ_BINDING.html Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. 30/47 Gene Ontology MF GO:0042805 1.28031587413046e-07 8.2820001624993e-07 90 226.909090909091 129 1.16392358967269e-08 74 2.63764049794966 2.86572523818665 1 17.1193213224553 366 90 121 90 95 572 624 137 74 129 198 53 M18056 GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. 18/21 Gene Ontology MF GO:1990939 1.53293387793137e-07 8.2820001624993e-07 100 131 130 1.39357634976763e-08 69 2.23462802040543 2.25418161205711 1 14.5036118467108 96 130 237 216 138 150 69 71 131 123 80 54 M18852 GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with platelet-derived growth factor. 22/23 Gene Ontology MF GO:0048407 2.95353984144042e-07 9.30984999064807e-07 5 224.454545454545 130 2.68503657996233e-08 3 4.06690631309248 4.06690631309248 1 26.1753098230836 3 414 48 263 860 73 82 319 156 130 121 55 M17957 GO_SULFUR_COMPOUND_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BINDING.html Interacting selectively and non-covalently with a sulfur compound. 231/344 Gene Ontology MF GO:1901681 5.05968073302486e-22 5.84393124664371e-20 370 174.454545454545 131 4.59970975729531e-23 5 3.11007308714117 3.36467057767103 1 63.8349497233324 18 369 5 336 368 87 164 131 302 24 115 56 M18284 GO_STEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BINDING.html Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. 40/56 Gene Ontology MF GO:0032934 1.34579190944823e-07 8.2820001624993e-07 75 231 131 1.22344726524865e-08 58 1.9143385854057 -1.76331379751454 -1 12.4248074503439 153 71 315 562 107 58 131 102 750 220 72 57 M18613 GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 18/41 Gene Ontology MF GO:0015125 1.34980080625358e-07 8.2820001624993e-07 135 153.545454545455 131 1.22709171733641e-08 63 4.74282383105095 -4.94870007329171 -1 30.7827890794012 95 129 63 79 108 265 215 134 181 289 131 58 M18911 GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. 22/74 Gene Ontology MF GO:0005230 8.22627866059606e-08 8.2820001624993e-07 885 424.181818181818 132 7.4784354256314e-09 25 2.75482089891467 -2.61205887814578 -1 17.8798682093493 885 105 67 36 25 900 858 894 132 41 723 59 M18333 GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. 26/39 Gene Ontology MF GO:0005520 3.34493306388986e-07 9.67001407265299e-07 265 170.272727272727 133 3.04084870223787e-08 6 3.01608739666418 3.4272279112577 1 19.3589993429232 129 99 95 264 391 206 264 6 118 133 168 60 M19121 GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 26/31 Gene Ontology MF GO:0008191 1.61233253542616e-08 3.04039849537505e-07 5 218.272727272727 134 1.46575686112963e-09 4 3.93319792257773 3.95702842079353 1 27.3547255661905 4 297 41 261 789 60 121 369 215 134 110 61 M19086 GO_EPHRIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_ACTIVITY.html Combining with an ephrin to initiate a change in cell activity. 14/20 Gene Ontology MF GO:0005003 1.86034977846171e-06 3.08610986588622e-06 35 190.727272727273 135 1.69122850145503e-07 33 3.49783787053911 3.86944362828839 1 20.5698848499196 34 440 186 40 547 137 56 89 33 401 135 62 M18619 GO_OXYGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_BINDING.html Interacting selectively and non-covalently with oxygen (O2). 18/94 Gene Ontology MF GO:0019825 3.32292110408734e-07 9.67001407265299e-07 120 191.545454545455 140 3.02083782362514e-08 52 2.94628149098361 -3.11144440673412 -1 18.910944461669 119 135 126 140 295 108 52 534 217 181 200 63 M19055 GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY.html Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. 19/40 Gene Ontology MF GO:0008329 5.0914822422968e-07 1.22389859342437e-06 95 251.363636363636 140 4.62862129147643e-08 24 2.683798977344 -2.7920844485643 -1 16.9331318373532 24 492 140 680 362 41 95 93 597 156 85 64 M17963 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. 26/28 Gene Ontology MF GO:0052866 7.51052659803372e-07 1.5387420347191e-06 35 257.727272727273 141 6.82775378366853e-08 31 1.1905767346167 -1.33786558954924 -1 7.38549168100193 58 303 563 405 437 31 87 80 141 697 33 65 M18475 GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES.html Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance. 99/130 Gene Ontology MF GO:0043492 1.5455120459311e-07 8.2820001624993e-07 45 191.909090909091 142 1.40501104954925e-08 12 2.14914439419098 -2.01573492669653 -1 13.9487894936346 45 385 240 406 142 12 74 46 545 190 26 66 M18654 GO_GLUCURONOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. 16/36 Gene Ontology MF GO:0015020 2.76640811180798e-07 9.30984999064807e-07 120 131.090909090909 143 2.51491678152028e-08 7 2.65121333704512 2.84103565139955 1 17.0636648948682 120 143 176 211 252 169 47 7 70 231 16 67 M18236 GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 11/14 Gene Ontology MF GO:0004185 6.61798543191771e-06 8.77334080214055e-06 115 191.454545454545 144 6.0163684909647e-07 34 2.99593586256077 3.03564282073564 1 16.1675969114811 86 176 217 144 688 112 158 34 113 264 114 68 M18209 GO_GLUTATHIONE_PEROXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_PEROXIDASE_ACTIVITY.html Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. 11/17 Gene Ontology MF GO:0004602 1.33112731041974e-07 8.2820001624993e-07 270 202.363636363636 147 1.21011580996423e-08 26 2.13069451713163 -1.63000187873212 -1 13.8290425355639 132 339 267 267 100 146 60 147 26 479 263 69 M18747 GO_BETA_AMYLOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_BINDING.html Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. 32/39 Gene Ontology MF GO:0001540 9.74706479620791e-08 8.2820001624993e-07 215 208.909090909091 147 8.86096838913645e-09 43 2.10063137239488 2.42741358253515 1 13.6339209030086 147 88 211 622 43 52 104 213 476 209 133 70 M18137 GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic hydroxy compound from one side of the membrane to the other. 51/92 Gene Ontology MF GO:1901618 6.86831102873669e-13 2.26654263948311e-11 70 161.090909090909 148 6.24391911703529e-14 21 3.86776096200627 -4.28983743827546 -1 43.9364204152251 279 43 21 68 70 384 363 155 148 63 178 71 M17969 GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. 24/29 Gene Ontology MF GO:0016411 2.47094456541763e-07 9.05170150212826e-07 95 216.454545454545 149 2.24631349358495e-08 31 1.6752764091162 -1.70839362954771 -1 10.8041995014307 91 114 429 560 229 93 149 31 172 407 106 72 M18349 GO_SIGNALING_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_RECEPTOR_ACTIVITY.html Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 541/2031 Gene Ontology MF GO:0038023 1.18769099607785e-29 4.83380238516913e-27 235 214.909090909091 149 1.18769099607784e-30 2 2.61473400673485 2.74472659838712 1 73.430563810147 83 234 847 3 86 13 273 232 442 2 149 73 M18390 GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. 19/19 Gene Ontology MF GO:0071617 5.18590238705793e-07 1.22409576110973e-06 140 260.090909090909 151 4.71445782681269e-08 76 1.69679742978766 -1.74845822461722 -1 10.7056273737978 151 136 406 621 370 147 147 76 138 482 187 74 M18429 GO_RAB_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GTPASE_BINDING.html Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. 122/135 Gene Ontology MF GO:0017137 5.87614279478543e-08 8.2820001624993e-07 60 195.909090909091 151 5.34194813794153e-09 1 1.57453920567503 -1.68373694054275 -1 10.219375839815 59 1 473 462 6 24 151 218 168 518 75 75 M18781 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. 16/20 Gene Ontology MF GO:0019198 4.07658714405169e-07 1.09499026776272e-06 70 213 151 3.70598899949191e-08 43 2.63824418049482 3.12804537749943 1 16.7817945722778 69 151 160 184 325 82 43 49 791 385 104 76 M17878 GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. 27/37 Gene Ontology MF GO:0008376 1.9122543864531e-07 8.40700906161521e-07 300 192.454545454545 152 1.73841322969774e-08 66 2.48440197296534 2.39359995351465 1 16.107493036683 110 104 142 299 186 94 66 475 299 152 190 77 M18337 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. 49/79 Gene Ontology MF GO:0015171 9.25840306206366e-08 8.2820001624993e-07 540 332.818181818182 152 8.41673041062825e-09 39 2.57011796887304 2.91238248107732 1 16.6810735535322 539 48 83 124 39 694 725 509 152 62 686 78 M18839 GO_GLYCOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_BINDING.html Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 130/193 Gene Ontology MF GO:0001948 6.23161669026339e-12 1.6977674818473e-10 25 132.090909090909 156 5.66510608207368e-13 22 2.793784717858 3.13400948577735 1 29.129104041266 22 261 24 160 156 131 191 164 170 38 136 79 M17881 GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. 122/204 Gene Ontology MF GO:0022853 1.73932300051134e-07 8.37618242795071e-07 170 129.272727272727 157 1.5812028527477e-08 2 2.20728130009293 -2.24692662515874 -1 14.3145530339383 167 2 93 41 167 70 179 157 344 45 157 80 M18125 GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. 19/36 Gene Ontology MF GO:0005227 1.08394431375694e-07 8.2820001624993e-07 365 207.090909090909 158 9.85403970148269e-09 22 3.23366985442574 -2.00136542098577 -1 20.9877862520189 361 125 118 95 64 158 177 370 22 247 541 81 M18686 GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY.html Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. 23/25 Gene Ontology MF GO:0042813 7.32107506912986e-07 1.51674290669865e-06 60 170.727272727273 158 6.65552500491828e-08 35 2.07116151909889 2.37950176878637 1 12.8618385548135 60 108 202 346 432 39 35 207 166 158 125 82 M18157 GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY.html Combining with a neuropeptide to initiate a change in cell activity. 12/49 Gene Ontology MF GO:0008188 5.00738814906981e-07 1.21909632942585e-06 65 194.363636363636 159 4.5521720807223e-08 11 4.04577694699204 4.34552480498217 1 25.5337539609511 65 170 88 465 402 159 337 11 184 110 147 83 M18873 GO_PEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 121/252 Gene Ontology MF GO:0030414 5.03368372257568e-21 3.90683088827641e-19 60 192.181818181818 159 4.57607611143244e-22 7 3.21071928996302 3.30858530361469 1 63.0735558315938 56 265 7 159 98 120 170 415 482 25 317 84 M17888 GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 91/210 Gene Ontology MF GO:0005244 9.04887806142257e-13 2.78705444291815e-11 215 140.636363636364 160 8.22625278311483e-14 15 3.23874403465164 3.56128702309395 1 36.4806946452553 211 15 22 19 152 160 281 230 185 29 243 85 M18656 GO_ION_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. 29/51 Gene Ontology MF GO:0022839 2.60420218271701e-07 9.23961214138929e-07 215 179.363636363636 160 2.3674568099853e-08 84 3.106759573819 -2.46616348405855 -1 20.0065435999127 215 94 84 173 242 127 160 400 102 230 146 86 M17972 GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 113/188 Gene Ontology MF GO:0072509 1.68337444381293e-07 8.2829858135462e-07 185 166.454545454545 161 1.5303405205634e-08 6 2.28883101033764 2.59813072589213 1 14.8552843290371 184 6 98 176 161 187 406 152 146 105 210 87 M18916 GO_STEROID_HYDROXYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HYDROXYLASE_ACTIVITY.html Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. 12/72 Gene Ontology MF GO:0008395 9.19639978864691e-07 1.78894176941258e-06 400 282.636363636364 161 8.36036693901035e-08 15 4.26416165287637 3.76288138185452 1 26.1540878277747 399 156 62 15 460 339 474 919 45 79 161 88 M18498 GO_CALMODULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_BINDING.html Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. 160/244 Gene Ontology MF GO:0005516 3.64661907304812e-07 1.01754674080225e-06 75 164 162 3.31510879772282e-08 74 2.45764258859072 2.73330227983422 1 15.7165421857601 74 258 79 85 309 171 218 162 187 107 154 89 M18397 GO_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). 1045/1327 Gene Ontology MF GO:0032403 1.25179790645832e-07 8.2820001624993e-07 165 247.727272727273 163 1.25179797697323e-08 67 2.08476875575204 2.35577571519985 1 13.5309662825571 163 222 853 75 114 95 410 249 332 67 145 90 M18655 GO_ANNEALING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANNEALING_ACTIVITY.html A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide. 15/15 Gene Ontology MF GO:0097617 2.15795673785137e-06 3.48593011499068e-06 75 236.454545454545 163 1.96178077688294e-07 37 1.78074388359414 1.82656776024062 1 10.3715525012217 73 330 400 321 563 37 41 163 111 442 120 91 M18556 GO_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 47/72 Gene Ontology MF GO:0043394 1.17625963374074e-15 5.72033632408656e-14 10 198 164 1.06932693976431e-16 6 3.81652175122596 3.70568696704913 1 53.935477401455 6 280 13 258 715 164 192 235 125 39 151 92 M19106 GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). 29/59 Gene Ontology MF GO:0015370 2.33122800961578e-10 5.25379190459751e-09 820 324.545454545455 164 2.11929819078436e-11 21 3.31204810255132 2.66199836207927 1 29.2641814828673 819 76 32 81 21 693 649 255 164 36 744 93 M19226 GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. 38/59 Gene Ontology MF GO:0005544 1.97359590154624e-07 8.48187261873824e-07 170 141.363636363636 164 1.79417825326853e-08 26 2.21585713789314 -2.27621873083784 -1 14.3572913971848 133 63 146 26 193 167 200 178 115 164 170 94 M18341 GO_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. 54/106 Gene Ontology MF GO:0005253 1.09345084625682e-07 8.2820001624993e-07 85 171.909090909091 165 9.94046273276241e-09 32 2.60406541074665 -2.54450752252688 -1 16.9014058021195 296 45 82 32 67 233 437 227 165 83 224 95 M18565 GO_INTEGRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_BINDING.html Interacting selectively and non-covalently with an integrin. 137/163 Gene Ontology MF GO:0005178 4.21938984151379e-09 8.66381380790831e-08 165 197.454545454545 165 3.83580895418744e-10 13 2.58554296266414 2.77128899233387 1 19.4863972288062 13 383 37 205 333 117 165 188 508 59 164 96 M18102 GO_ARYL_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYL_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. 2/15 Gene Ontology MF GO:0004062 9.6964224481196e-07 1.84854077904815e-06 190 318.8 167.5 1.07738073631287e-07 3 3.86199593907691 -3.86199593907691 -1 23.6287587154351 187 528 823 NA 850 148 3 13 18 569 49 97 M18672 GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). 18/36 Gene Ontology MF GO:0005343 8.59426787281745e-08 8.2820001624993e-07 795 359.545454545455 169 7.81297109868301e-09 30 2.91858387630439 2.46249371329817 1 18.9427543372048 793 118 73 93 30 662 565 510 169 76 866 98 M18958 GO_MYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_BINDING.html Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. 80/108 Gene Ontology MF GO:0017022 1.53641991554578e-07 8.2820001624993e-07 760 339.727272727273 175 1.39674547531378e-08 26 2.45213025614471 -1.83901417681475 -1 15.9152868957951 606 26 91 87 140 463 534 759 98 175 758 99 M18315 GO_POLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 15/23 Gene Ontology MF GO:0030247 1.81612993155641e-07 8.37618242795071e-07 145 277.545454545455 177 1.65102734680039e-08 130 2.51514032949748 2.88294007422258 1 16.31106579248 145 508 232 474 177 172 142 130 727 206 140 100 M18848 GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). 19/28 Gene Ontology MF GO:0015295 2.98327148681749e-07 9.30984999064807e-07 70 206.909090909091 178 2.71206535578079e-08 9 1.68458202478504 -1.31072197376673 -1 10.8422585286378 67 321 443 398 266 30 19 9 178 403 142 101 M18707 GO_CHEMOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_BINDING.html Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 14/31 Gene Ontology MF GO:0019956 3.86904938122453e-06 5.69267775199278e-06 20 269.272727272727 179 3.51732380507187e-07 16 3.12998013257914 3.12998013257914 1 17.5184243246096 26 567 179 276 819 17 16 23 658 308 73 102 M17960 GO_SYNTAXIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_BINDING.html Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. 91/123 Gene Ontology MF GO:0019905 1.60403495049449e-07 8.2820001624993e-07 335 191.818181818182 180 1.45821369767799e-08 18 1.81994060057666 -1.63300721240738 -1 11.812127404026 180 18 313 98 154 48 275 268 335 331 90 103 M18509 GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 17/22 Gene Ontology MF GO:0099604 4.03228383290398e-07 1.08624788968026e-06 60 191.181818181818 180 3.66571324723986e-08 58 2.52071353680423 3.36351563726671 1 16.0435502875454 223 128 180 58 324 304 492 62 60 203 69 104 M18819 GO_TITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TITIN_BINDING.html Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. 16/28 Gene Ontology MF GO:0031432 3.6491456307126e-07 1.01754674080225e-06 160 279 180 3.3174056690886e-08 61 1.95260596840263 1.68111514976379 1 12.4868493015847 156 149 302 61 310 180 120 875 357 386 173 105 M17886 GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 14/19 Gene Ontology MF GO:0070008 4.64463055140509e-06 6.60252096845893e-06 145 231.454545454545 181 4.22240032468922e-07 77 2.64475498306038 2.75020374599771 1 14.6208864572188 143 161 253 145 640 181 314 77 112 306 214 106 M17901 GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING.html Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. 18/23 Gene Ontology MF GO:0001965 1.11526211424893e-06 2.04871211444535e-06 25 210.545454545455 182 1.01387516328848e-07 23 2.46964741534439 2.79165128093199 1 14.9923027819281 23 137 230 467 489 45 57 182 306 287 93 107 M18188 GO_FAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 13/15 Gene Ontology MF GO:0071949 7.06267632936092e-08 8.2820001624993e-07 165 231.090909090909 182 6.42061505099507e-09 13 1.73736324553695 -1.58667280754894 -1 11.2761678938503 321 165 420 236 13 163 136 290 153 463 182 108 M18217 GO_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 116/193 Gene Ontology MF GO:0016247 1.62111525491878e-07 8.2829858135462e-07 705 284.727272727273 183 1.47374124943091e-08 3 2.60028228387226 -2.39521359288944 -1 16.8767084037007 702 3 58 24 155 551 768 225 183 75 388 109 M19143 GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. 17/30 Gene Ontology MF GO:0070001 1.84928702954756e-07 8.37618242795071e-07 135 251.454545454545 183 1.68117016817806e-08 40 2.0855266546968 -2.2769586960694 -1 13.52495558924 131 426 401 349 183 130 135 402 144 425 40 110 M19200 GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a calcium channel. 35/62 Gene Ontology MF GO:0005246 7.33404227173547e-08 8.2820001624993e-07 780 376.454545454545 183 6.66731137838834e-09 16 2.98320571857611 3.18054296762907 1 19.362175507984 777 81 107 48 16 762 826 574 124 183 643 111 M18143 GO_LYSOPHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPASE_ACTIVITY.html Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. 19/23 Gene Ontology MF GO:0004622 5.14531123583988e-07 1.22409576110973e-06 185 281.909090909091 185 4.67755676292205e-08 91 2.60272818297323 -2.49808175118125 -1 16.421430257235 106 131 181 528 367 91 97 698 519 198 185 112 M19039 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. 13/76 Gene Ontology MF GO:0016712 1.89076387291822e-07 8.40700906161521e-07 690 304.090909090909 185 1.71887639583427e-08 30 3.91149714551072 -4.117766727426 -1 25.3599931778753 688 157 94 30 185 389 289 789 89 145 490 113 M18140 GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). 11/20 Gene Ontology MF GO:0015299 3.35423628987088e-06 5.03953549892796e-06 95 229.454545454545 186 3.04931036720704e-07 10 2.34249204357459 -2.18184899278784 -1 13.2431783253236 92 343 325 186 606 67 10 32 564 263 36 114 M18218 GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. 11/12 Gene Ontology MF GO:0052743 1.91726332631504e-06 3.15591367892489e-06 200 278.454545454545 186 1.74296817925464e-07 46 1.1270094676914 -1.47654472748803 -1 6.61596805342066 200 185 525 248 552 143 127 186 46 751 100 115 M19119 GO_CADHERIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CADHERIN_BINDING.html Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. 29/34 Gene Ontology MF GO:0045296 1.3333341381327e-07 8.2820001624993e-07 445 290.909090909091 187 1.21212201721898e-08 72 2.63092553651942 -2.11821828828661 -1 17.0757385819174 441 89 143 168 101 317 270 845 72 187 567 116 M18857 GO_SNARE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_BINDING.html Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 123/160 Gene Ontology MF GO:0000149 1.93461387629831e-07 8.40700906161521e-07 115 217.545454545455 188 1.75874004220223e-08 4 1.77397183551395 -1.54073761685216 -1 11.5014547895266 115 4 427 306 188 15 183 196 397 499 63 117 M18123 GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. 37/60 Gene Ontology MF GO:0015179 1.06945351754572e-07 8.2820001624993e-07 905 427 190 9.72230517757713e-09 61 2.44976126229014 2.60834934239236 1 15.8999111940026 689 67 115 91 61 797 902 813 190 71 901 118 M18794 GO_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_ACTIVITY.html Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. 99/144 Gene Ontology MF GO:0003774 2.1204684845543e-07 8.48926288617081e-07 210 179.454545454545 191 1.92769880812321e-08 16 2.08811852864885 2.20109996168995 1 13.5287865204004 175 16 208 125 206 185 306 212 116 191 234 119 M19114 GO_CELL_ADHESION_MOLECULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MOLECULE_BINDING.html Interacting selectively and non-covalently with a cell adhesion molecule. 218/272 Gene Ontology MF GO:0050839 1.6404977580397e-20 1.0827285203062e-18 250 174.454545454545 191 1.49136159821791e-21 10 2.78881344536925 3.02192612790759 1 53.4678264969758 42 247 10 157 136 191 291 283 247 13 302 120 M18646 GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a carboxylic ester bond. 97/170 Gene Ontology MF GO:0052689 1.94707785626153e-07 8.40700906161521e-07 65 271.727272727273 192 1.77007093507712e-08 61 2.18486952482675 -2.07407486164837 -1 14.1654893973947 61 536 258 620 192 77 113 108 465 383 176 121 M18268 GO_ALCOHOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BINDING.html Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. 85/136 Gene Ontology MF GO:0043178 1.79941154804846e-07 8.37618242795071e-07 85 243.090909090909 193 1.63582881384085e-08 10 2.01731320932923 -1.91302457689261 -1 13.0825809925168 84 272 276 619 174 10 77 193 679 196 94 122 M18336 GO_TROPOMYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPOMYOSIN_BINDING.html Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. 9/14 Gene Ontology MF GO:0005523 1.54732164095313e-06 2.6673977541804e-06 460 292.272727272727 193 1.5473227183461e-07 17 2.59242304638717 3.62340140024275 1 15.4205609704195 456 188 845 169 538 458 287 17 40 193 24 123 M18812 GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. 20/35 Gene Ontology MF GO:0005217 2.12235428197397e-07 8.48926288617081e-07 195 204.090909090909 193 1.92941316974444e-08 102 2.61293761041396 3.41757153763506 1 16.9290565297196 193 121 172 149 207 234 312 143 389 223 102 124 M19031 GO_DEATH_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_ACTIVITY.html Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. 20/23 Gene Ontology MF GO:0005035 6.40735009489606e-07 1.37256281552322e-06 450 281.636363636364 195 5.82486541908535e-08 64 2.30596358072495 2.81704878829841 1 14.4267026599798 448 122 195 428 415 400 578 64 157 180 111 125 M18790 GO_SIALYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. 12/21 Gene Ontology MF GO:0008373 5.17746149070462e-06 7.23748020788362e-06 55 245.181818181818 196 4.70679425030825e-07 50 2.6703421594212 2.82411783413838 1 14.6486992569173 52 340 196 381 650 118 138 50 327 316 129 126 M18560 GO_MYOSIN_HEAVY_CHAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_HEAVY_CHAIN_BINDING.html Interacting selectively and non-covalently with a heavy chain of a myosin complex. 19/27 Gene Ontology MF GO:0032036 9.80404623439957e-08 8.2820001624993e-07 200 246.727272727273 197 8.91276970118688e-09 37 2.29873360347976 -2.10360325431904 -1 14.9196822922648 548 120 197 37 46 599 458 169 59 199 282 127 M19034 GO_LAMININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMININ_BINDING.html Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. 32/43 Gene Ontology MF GO:0043236 6.65952383795575e-07 1.40488585074683e-06 115 195.181818181818 197 6.05411441257451e-08 28 2.74171011689543 2.80596891542701 1 17.1232687520472 28 294 114 210 425 197 208 112 258 169 132 128 M18129 GO_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. 23/41 Gene Ontology MF GO:0004180 2.03400721959645e-07 8.48926288617081e-07 85 191 198 1.8490976433185e-08 43 2.59100003702322 3.32607270590607 1 16.7869243636655 85 307 249 275 198 53 214 150 75 452 43 129 M18782 GO_NADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_BINDING.html Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. 40/65 Gene Ontology MF GO:0050661 1.27939359291792e-07 8.2820001624993e-07 190 250 199 1.16308515210919e-08 74 2.10398887828989 -2.56659692604798 -1 13.6557124367049 199 74 294 390 94 190 167 189 670 221 262 130 M18295 GO_CATION_SUGAR_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_SUGAR_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). 13/16 Gene Ontology MF GO:0005402 2.40514403191828e-06 3.81192639021011e-06 205 203.818181818182 201 2.18649696485409e-07 20 1.86214351769877 -1.44466156487944 -1 10.7684912380541 75 331 324 302 574 100 23 20 88 204 201 131 M18617 GO_ENZYME_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_INHIBITOR_ACTIVITY.html Binds to and stops, prevents or reduces the activity of an enzyme. 301/494 Gene Ontology MF GO:0004857 4.42137294413185e-13 1.63413944015113e-11 165 182.363636363636 201 4.01942994921158e-14 19 2.54077803006132 2.77589081013632 1 29.2475826002385 161 240 19 201 59 29 269 335 436 49 208 132 M19213 GO_SEMAPHORIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_ACTIVITY.html Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 9/11 Gene Ontology MF GO:0017154 8.40355599985983e-06 1.07995629261064e-05 115 307.272727272727 201 8.40358777891801e-07 38 2.07567739977338 2.52734244669303 1 11.0015187356053 111 201 924 352 718 134 38 66 433 275 128 133 M18189 GO_CLATHRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_BINDING.html Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. 50/71 Gene Ontology MF GO:0030276 1.51982048660317e-07 8.2820001624993e-07 365 232.181818181818 202 1.3816550832696e-08 33 2.10540446574416 -2.40284060842264 -1 13.6649001560044 365 54 183 33 137 202 376 487 133 236 348 134 M18179 GO_METALLOCARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOCARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 13/28 Gene Ontology MF GO:0004181 1.99024678585054e-06 3.24909545958639e-06 225 237.818181818182 206 1.80931689667705e-07 64 3.46586152372457 4.37512233360935 1 20.2991708765971 118 434 166 224 556 157 223 206 64 369 99 135 M17855 GO_BETA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_BINDING.html Interacting selectively and non-covalently with the beta subunit of the catenin complex. 103/129 Gene Ontology MF GO:0008013 1.74885793069488e-07 8.37618242795071e-07 185 261.090909090909 207 1.58987097247073e-08 14 2.12464133127544 2.65906967861034 1 13.7786202323935 182 14 207 182 169 200 304 581 251 493 289 136 M18067 GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 71/145 Gene Ontology MF GO:0015103 2.12927099054221e-07 8.48926288617081e-07 210 295.818181818182 209 1.93570108783984e-08 25 2.39885639975545 -2.53697302952132 -1 15.5420377541967 649 31 72 25 209 537 668 408 207 46 402 137 M18545 GO_INTERMEDIATE_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BINDING.html Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. 24/27 Gene Ontology MF GO:0019215 1.47754746034182e-06 2.56626664164632e-06 110 275.090909090909 209 1.34322586607461e-07 110 3.10401051781485 3.49998840791628 1 18.5192511759389 194 110 110 209 523 188 343 294 609 176 270 138 M18623 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other. 104/171 Gene Ontology MF GO:0005342 4.67417046253175e-09 9.38898588560725e-08 40 293.272727272727 209 4.2492458840569e-10 8 2.70976441330047 -2.75453601827784 -1 20.3216631387794 597 8 38 77 53 354 477 862 209 37 514 139 M18774 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. 15/15 Gene Ontology MF GO:0016307 4.84385437290257e-07 1.21293263971869e-06 240 200 212 4.40350494490863e-08 24 2.36160057868667 -2.79856650305793 -1 14.9101074209609 238 147 238 178 348 212 227 38 24 523 27 140 M18805 GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. 42/74 Gene Ontology MF GO:0008028 8.25459619943909e-08 8.2820001624993e-07 485 274 212 7.50417864468991e-09 26 3.2264518935682 -3.88436684528515 -1 20.9409388473785 481 62 54 83 26 503 485 615 212 99 394 141 M18222 GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS.html The action of a molecule that contributes to the structural integrity of the lens of an eye. 6/22 Gene Ontology MF GO:0005212 3.43605821222677e-06 5.12910789676499e-06 80 303.818181818182 213 3.43606352516154e-07 7 1.98572295665276 1.98572295665276 1 11.2099851778182 76 213 836 472 618 42 7 36 677 347 18 142 M17882 GO_CYTOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_BINDING.html Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 93/153 Gene Ontology MF GO:0019955 4.13826973899583e-06 6.01373764917235e-06 630 327.272727272727 214 3.76207047566626e-07 44 2.27823531628428 2.41979039053595 1 12.6932961257239 44 603 168 627 626 105 100 273 659 214 181 143 M18195 GO_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). 48/84 Gene Ontology MF GO:0015297 6.17982634325605e-07 1.34545709347279e-06 410 204.090909090909 215 5.61802552652487e-08 55 2.01720472841122 -2.03332085711865 -1 12.6388000083714 245 55 219 215 407 126 230 107 410 87 144 144 M18573 GO_ACETYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_BINDING.html Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. 5/20 Gene Ontology MF GO:0042166 6.58719952370722e-06 8.74507522974923e-06 130 282.363636363636 215 6.58721904982759e-07 42 2.28462280205393 -2.68767092395732 -1 12.3324052679575 126 215 867 312 692 92 42 59 385 269 47 145 M18665 GO_WIDE_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WIDE_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. 12/27 Gene Ontology MF GO:0022829 1.75358834044941e-06 2.93004634100407e-06 130 256.818181818182 216 1.59417248928272e-07 28 3.64356006020483 4.36893527134062 1 21.5144699742295 128 446 201 269 543 297 181 99 28 417 216 146 M18897 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 113/180 Gene Ontology MF GO:0016614 1.93807113322523e-07 8.40700906161521e-07 105 300 216 1.76188300359815e-08 9 1.70522891085207 -1.97976721802537 -1 11.0557634772888 105 9 466 780 190 173 216 158 617 359 227 147 M18680 GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. 104/148 Gene Ontology MF GO:0008194 1.14887974785758e-07 8.2820001624993e-07 220 207.454545454545 217 1.04443618895833e-08 13 2.45714284226869 2.64513848991813 1 15.9478205510864 217 13 99 376 71 210 374 274 237 114 297 148 M18470 GO_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 63/81 Gene Ontology MF GO:0003777 5.55756115114807e-07 1.26879706209363e-06 70 215.636363636364 218 5.05232959552705e-08 66 2.04478234548598 2.345336006706 1 12.8671833790245 66 393 268 379 385 107 157 78 239 218 82 149 M18779 GO_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBULIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. 288/374 Gene Ontology MF GO:0015631 2.23545635073793e-07 8.642517439673e-07 340 226.636363636364 218 2.03223325262398e-08 109 1.85546894876557 2.26609225443956 1 12.006078477366 177 242 339 337 218 125 368 132 236 210 109 150 M18216 GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of cation from one side of the membrane to the other. 390/681 Gene Ontology MF GO:0008324 2.54776824267679e-13 1.02353819836233e-11 220 221 219 2.31615294788826e-14 17 2.42791333163728 -2.20095927358 -1 28.4748189341347 398 236 17 118 80 216 358 341 219 21 427 151 M18984 GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON.html The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 105/144 Gene Ontology MF GO:0005200 1.21728745687873e-08 2.34327835449155e-07 290 244.727272727273 219 1.10662496692194e-09 7 2.86799631608293 2.97578759699179 1 20.2926071318737 286 7 40 66 219 390 654 490 163 53 324 152 M19035 GO_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glutamate receptor. 43/50 Gene Ontology MF GO:0035254 9.23956535355329e-07 1.79356268627799e-06 595 332.272727272727 219 8.39960839453678e-08 45 1.98325327352324 -2.16204022860699 -1 12.1618425524458 591 57 209 45 461 638 854 110 301 170 219 153 M19009 GO_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. 91/156 Gene Ontology MF GO:0015293 8.92304351627436e-09 1.7542323849016e-07 535 189.454545454545 220 8.11185777496869e-10 12 2.57039751133974 -2.65905895099934 -1 18.5318390642954 532 12 39 18 35 242 348 220 226 30 382 154 M18118 GO_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_LIPASE_ACTIVITY.html Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. 10/30 Gene Ontology MF GO:0004806 1.63032131200698e-06 2.76914869907068e-06 90 297.181818181818 221 1.4821113819693e-07 30 3.3330950892325 -3.11144642888626 -1 19.7684846377471 90 638 173 726 531 115 30 221 428 239 78 155 M19168 GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. 8/61 Gene Ontology MF GO:0008391 1.34144103175803e-06 2.36544181935958e-06 490 362.090909090909 221 1.34144184151753e-07 44 3.18645485323153 -2.44033964537812 -1 19.1314752106908 487 204 919 137 522 221 141 840 44 341 127 156 M18069 GO_MANNOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. 15/15 Gene Ontology MF GO:0015923 1.54690905000909e-07 8.2820001624993e-07 270 250.727272727273 222 1.40628105343504e-08 21 1.74407384992881 -1.71795294435562 -1 11.3197223554955 268 427 441 222 143 266 186 185 21 439 160 157 M18776 GO_NEUREXIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUREXIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. 12/14 Gene Ontology MF GO:0042043 2.41559401645674e-07 8.96389104902017e-07 240 185.818181818182 222 2.19599480153486e-08 35 2.66900876827652 -2.61045277882491 -1 17.2250426764394 239 164 171 35 227 222 285 166 65 238 232 158 M19223 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. 78/152 Gene Ontology MF GO:0015081 2.27472353690734e-15 1.00087835623923e-13 20 295 222 2.06793048809758e-16 14 3.06044857158356 2.89183476056301 1 42.4570607394518 596 20 15 16 212 436 545 222 300 14 869 159 M18494 GO_PHOSPHATIDYLSERINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_BINDING.html Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. 43/62 Gene Ontology MF GO:0001786 3.34892262256381e-07 9.67001407265299e-07 65 264.909090909091 223 3.04447557486318e-08 64 2.3337289559665 2.42304807057795 1 14.9792262114261 152 610 223 252 297 65 92 203 574 382 64 160 M18878 GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. 143/254 Gene Ontology MF GO:0015291 4.8947660100179e-13 1.67733497362599e-11 590 231 223 4.44978728183545e-14 5 2.43076981077778 -2.60047867969301 -1 27.9518557726356 586 257 31 5 106 273 460 223 218 11 371 161 M18939 GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. 11/28 Gene Ontology MF GO:0030898 7.0446753145166e-08 8.2820001624993e-07 330 259.545454545455 223 6.40425049099628e-09 12 2.34274948034001 2.44296636452082 1 15.2053626436229 327 184 322 108 12 441 602 33 19 584 223 162 M17913 GO_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLASE_ACTIVITY.html Catalysis of a ring closure reaction. 16/23 Gene Ontology MF GO:0009975 1.32771820888981e-06 2.35147110274123e-06 5 218.818181818182 225 1.20701728198129e-07 2 2.6361405679373 2.64936883752033 1 15.8346250486395 46 501 231 225 511 20 4 35 534 298 2 163 M17869 GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. 19/21 Gene Ontology MF GO:0034237 2.66166996822259e-06 4.13745784406549e-06 230 317.363636363636 228 2.41970289859038e-07 134 2.44138604860133 2.71970987230046 1 14.0254401201863 228 320 311 188 586 201 194 710 134 402 217 164 M18165 GO_CALCIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_BINDING.html Interacting selectively and non-covalently with calcium ions (Ca2+). 528/853 Gene Ontology MF GO:0005509 1.55091022598156e-18 8.95650655504349e-17 5 216 228 1.55091022598156e-19 1 2.74140324865722 2.97670974979166 1 46.9487803568784 93 235 832 1 81 75 260 257 309 5 228 165 M18948 GO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger to initiate a change in cell activity. 729/2329 Gene Ontology MF GO:0004872 3.36897136998696e-37 3.11292954586795e-34 5 274.454545454545 228 3.36897136998693e-38 1 2.67540980443057 2.74488143390226 1 95.6660641986943 176 228 900 2 124 14 359 458 435 1 322 166 M18457 GO_GROWTH_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_ACTIVITY.html The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 101/168 Gene Ontology MF GO:0008083 4.90130349436165e-13 1.67733497362599e-11 145 213.909090909091 229 4.45573044942066e-14 11 3.2432920166595 3.408002624603 1 37.2951945440508 141 11 20 295 84 229 245 465 360 33 470 167 M18706 GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a substance from one side of a membrane to the other. 647/1090 Gene Ontology MF GO:0022857 7.01029561055341e-18 3.8103018495008e-16 310 276.090909090909 232 7.01029561055342e-19 6 2.4128074950604 -2.28087443536535 -1 39.7021703928498 306 232 874 115 116 208 338 205 265 6 372 168 M18584 GO_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 29/36 Gene Ontology MF GO:0008378 1.15312826024963e-07 8.2820001624993e-07 665 423.636363636364 233 1.04829847335523e-08 73 2.75389174428495 -2.49380663755343 -1 17.8738376303851 664 100 154 127 73 715 736 776 233 229 853 169 M19063 GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. 14/20 Gene Ontology MF GO:0004198 3.91584684499158e-05 4.4724876202376e-05 235 316.272727272727 234 3.5599241327966e-06 6 3.9485933998098 -3.76695531416321 -1 18.3278292461758 234 510 226 170 804 409 386 94 6 492 148 170 M18109 GO_LIGAND_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 74/161 Gene Ontology MF GO:0022834 1.85597336641744e-09 3.89754406947663e-08 35 373.909090909091 235 1.68724851634835e-10 24 2.84445912456476 -2.78222976022361 -1 22.4908433254753 911 24 35 29 68 758 792 566 235 31 664 171 M18060 GO_ACTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. 362/479 Gene Ontology MF GO:0003779 1.47283944878253e-10 3.48949654019245e-09 480 309.363636363636 237 1.3389449535283e-11 7 2.17857346795662 2.40812175915539 1 19.6623270037323 477 237 34 64 7 679 821 499 127 19 439 172 M18114 GO_COLLAGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_BINDING.html Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 85/105 Gene Ontology MF GO:0005518 3.29263053050965e-11 8.45108502830809e-10 10 251.090909090909 237 2.9933004823263e-12 7 3.35694460749767 3.52350668166698 1 32.503751715799 7 389 27 202 697 246 209 295 355 98 237 173 M19042 GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). 10/23 Gene Ontology MF GO:0005416 2.5555476951489e-07 9.177676063928e-07 515 277.272727272727 238 2.3232254472769e-08 104 2.52776672866195 2.35257823455556 1 16.2858929062628 511 179 141 104 238 322 153 575 462 106 259 174 M17988 GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). 9/19 Gene Ontology MF GO:0005283 2.26286418108596e-07 8.67813463409488e-07 190 318.454545454545 239 2.26286441151094e-08 59 2.75874652977855 2.35257823455556 1 17.8456088206491 394 190 810 187 234 239 59 540 457 78 315 175 M18575 GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 327/580 Gene Ontology MF GO:0022890 2.80385678068987e-13 1.0794848605656e-11 240 326.454545454545 239 2.5489607097184e-14 18 2.5106894364704 -2.3032119452422 -1 29.3836995935827 644 239 18 161 171 479 540 488 238 27 586 176 M19171 GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any O-glycosyl bond. 69/105 Gene Ontology MF GO:0004553 9.12296380044225e-08 8.2820001624993e-07 40 248.727272727273 240 8.29360379886682e-09 37 1.69613345753954 -1.50213191081063 -1 11.0085703549232 265 38 382 558 37 156 240 173 404 388 95 177 M18079 GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of metal ions from one side of a membrane to the other. 247/461 Gene Ontology MF GO:0046873 1.82485853231314e-21 1.68616928385735e-19 10 347.727272727273 243 1.65896230210286e-22 6 2.72786221603606 2.82232355989215 1 54.6503098267246 476 243 6 74 162 402 702 904 229 8 619 178 M18551 GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. 15/22 Gene Ontology MF GO:0004653 9.89048418422736e-08 8.2820001624993e-07 295 287.636363636364 243 8.99134966261033e-09 48 2.88906113611162 2.9360435794568 1 18.7511401426698 291 148 138 386 48 351 176 847 243 207 329 179 M18981 GO_LIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BINDING.html Interacting selectively and non-covalently with a lipid. 593/886 Gene Ontology MF GO:0008289 9.51103934624979e-08 8.2820001624993e-07 420 346 244 9.51103975331923e-09 56 2.03773406156467 -2.02601670360071 -1 13.2256926195075 417 233 903 119 56 244 703 391 464 61 215 180 M18106 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a lipoprotein particle receptor. 20/30 Gene Ontology MF GO:0070325 4.70979025155474e-06 6.67461072459598e-06 40 283.363636363636 245 4.2816366676079e-07 20 2.22237969239026 2.48976391312561 1 12.274701540368 39 627 309 363 642 21 20 245 67 707 77 181 M18151 GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. 244/498 Gene Ontology MF GO:0022803 7.6826078964224e-24 1.41974593925886e-21 900 444.636363636364 245 6.9841889967476e-25 3 2.89897898433414 3.09736725005206 1 64.4969700300506 836 245 3 65 97 896 896 832 159 7 855 182 M18591 GO_PEPTIDE_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen peptide. 30/62 Gene Ontology MF GO:0042605 2.60189242468844e-06 4.07735454525613e-06 40 311.818181818182 245 2.36535954717767e-07 36 1.41268989282508 -1.24781960540488 -1 8.12529633826748 36 92 442 487 581 72 169 229 822 245 255 183 M18652 GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). 19/33 Gene Ontology MF GO:0015298 2.09207289326701e-05 2.47830173510092e-05 140 268.181818181818 245 1.90190253448761e-06 28 2.60498476914433 -2.22460233106993 -1 12.8040907082993 138 491 245 272 774 145 105 73 429 250 28 184 M18156 GO_MHC_CLASS_II_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_RECEPTOR_ACTIVITY.html Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 7/10 Gene Ontology MF GO:0032395 6.86378430326015e-06 9.07315693306492e-06 190 349.909090909091 246 6.86380550354303e-07 108 4.08442948051414 4.04221015789938 1 21.9780546764338 190 456 830 220 699 193 372 309 246 108 226 185 M18934 GO_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVITY.html Catalysis of the hydrolysis of a lipid or phospholipid. 81/132 Gene Ontology MF GO:0016298 2.79582965634314e-07 9.30984999064807e-07 115 261.181818181818 247 2.54166364695099e-08 28 2.28842837790193 -2.20320192571417 -1 14.7287181310303 247 28 131 616 256 174 407 312 477 112 113 186 M18196 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 15/29 Gene Ontology MF GO:0008519 5.010878742218e-07 1.21909632942585e-06 260 245.454545454545 249 4.55534534866569e-08 38 3.13216857510052 -2.87710146577634 -1 19.7677776642592 260 160 165 38 357 406 435 195 249 258 177 187 M18373 GO_AMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BINDING.html Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. 6/11 Gene Ontology MF GO:0043176 5.6261003130775e-07 1.26879706209363e-06 250 277.909090909091 249 5.62610173746322e-08 10 3.34049192737243 4.23630046757489 1 21.0206851495706 249 360 850 47 409 332 228 67 10 483 22 188 M18980 GO_APOLIPOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOLIPOPROTEIN_BINDING.html Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex. 20/26 Gene Ontology MF GO:0034185 7.44136567201696e-07 1.5315795040692e-06 250 321.545454545455 249 6.7648801718315e-08 163 3.1644815695514 3.44800804207682 1 19.6370415463553 196 560 167 249 433 249 284 442 569 225 163 189 M17908 GO_CYTOSKELETAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). 802/1066 Gene Ontology MF GO:0008092 8.24068221948507e-13 2.62565185200145e-11 340 284.818181818182 250 8.24068221948812e-14 12 2.12757201110128 2.51922965494552 1 24.0234541909193 338 226 804 63 34 341 623 303 139 12 250 190 M18124 GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY.html Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 6/26 Gene Ontology MF GO:0015464 0.000104209617955816 0.000113281984695499 150 377.818181818182 250 1.04214505118383e-05 146 2.27408709159024 -2.67450128587772 -1 9.57592191528652 146 457 827 476 847 198 236 148 250 346 225 191 M18578 GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a negatively charged ion from one side of a membrane to the other. 195/337 Gene Ontology MF GO:0008509 2.97673740824416e-12 8.87259795231484e-11 440 265.454545454545 250 2.70612491658926e-13 4 2.49660780812123 -2.54650164735545 -1 26.7814950622184 571 250 23 4 57 277 436 606 242 17 437 192 M18900 GO_PROTEIN_TYROSINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_BINDING.html Interacting selectively and non-covalently with protein tyrosine kinase. 66/84 Gene Ontology MF GO:1990782 2.61434275872045e-07 9.23961214138929e-07 450 340.090909090909 251 2.37667551762971e-08 39 2.16420337438507 2.14573989638908 1 13.9367805793214 604 39 178 233 243 448 229 448 331 251 737 193 M18082 GO_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. 161/349 Gene Ontology MF GO:0022836 7.62361962540736e-21 5.418634256828e-19 10 398.909090909091 253 6.93056329582484e-22 9 3.04590858919586 -2.67957148623432 -1 59.3741180391241 765 253 9 70 65 683 788 773 171 10 801 194 M18444 GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 10/15 Gene Ontology MF GO:0005247 2.76738789751876e-07 9.30984999064807e-07 330 223.818181818182 253 2.51580749602686e-08 22 2.67376713857303 -2.18086013561916 -1 17.20882506362 371 192 327 107 253 301 441 22 37 328 83 195 M18468 GO_FIBRONECTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRONECTIN_BINDING.html Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. 29/46 Gene Ontology MF GO:0001968 3.50432781435838e-06 5.21416892184726e-06 55 246.181818181818 255 3.18575763302862e-07 21 3.15575956296637 2.86738806762548 1 17.7911280792983 54 405 97 268 664 278 255 21 333 149 184 196 M19194 GO_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. 147/319 Gene Ontology MF GO:0005261 2.12175725218069e-17 1.08916872278609e-15 365 225.272727272727 256 1.92887022925517e-18 6 2.95541407010392 3.21755868491952 1 47.1920103672178 363 256 12 6 79 284 610 326 162 16 364 197 M18081 GO_ADRENERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_ACTIVITY.html Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. 4/26 Gene Ontology MF GO:0004935 8.78607692763637e-07 1.72372880315847e-06 280 293.363636363636 257 8.78608040141995e-08 63 3.30688084787689 -3.79249369266528 -1 20.3395517946446 230 216 819 138 469 279 279 266 63 211 257 198 M18598 GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY.html Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. 15/18 Gene Ontology MF GO:0005041 4.01807254935308e-05 4.58357905629907e-05 105 312.909090909091 258 3.65285994288231e-06 104 2.75532767940249 3.33899456835577 1 12.7578229559511 104 431 263 193 805 226 108 159 454 441 258 199 M18238 GO_STEROID_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_ACTIVITY.html Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. 42/63 Gene Ontology MF GO:0003707 1.84238940341869e-07 8.37618242795071e-07 260 310.909090909091 259 1.67489959791779e-08 89 2.09740337184365 -2.21709718781874 -1 13.6019779113046 259 548 283 495 180 199 253 171 639 304 89 200 M18288 GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING.html Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. 41/59 Gene Ontology MF GO:0050431 9.59732430489685e-06 1.21979747699102e-05 260 360.545454545455 259 8.72487833883035e-07 77 2.26215770938827 2.39359446918576 1 11.8622412247592 77 668 256 447 721 213 102 259 642 390 191 201 M17907 GO_PEPTIDASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_REGULATOR_ACTIVITY.html Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 161/301 Gene Ontology MF GO:0061134 1.398123040163e-15 6.45932844555305e-14 170 272.636363636364 260 1.27102094560273e-16 14 2.93836409938022 3.1361421350048 1 41.3598028381733 169 378 14 260 166 232 274 526 478 56 446 202 M18088 GO_ACTIN_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BINDING.html Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. 133/170 Gene Ontology MF GO:0051015 6.87007079877409e-08 8.2820001624993e-07 495 370.818181818182 260 6.24551910300897e-09 10 2.1547671430632 2.30741163005402 1 13.9852833451263 491 260 90 76 10 682 897 729 69 97 678 203 M18290 GO_SH3_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. 125/157 Gene Ontology MF GO:0017124 8.75429532132008e-08 8.2820001624993e-07 165 289.454545454545 263 7.95845060879384e-09 32 1.93486308967162 2.01510657305061 1 12.5580195548933 397 263 128 162 32 313 293 748 161 65 622 204 M18663 GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 123/213 Gene Ontology MF GO:0008514 6.95084134935852e-08 8.2820001624993e-07 780 366 264 6.31894688088047e-09 28 2.4613177044875 -2.53302132683963 -1 15.9749170487735 780 264 44 78 112 466 554 821 232 28 647 205 M18418 GO_BINDING_BRIDGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_BRIDGING.html The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. 183/250 Gene Ontology MF GO:0060090 1.00051334517389e-07 8.2820001624993e-07 770 447.818181818182 265 9.09557627886475e-09 52 2.02758372537861 -1.87633305875172 -1 13.1598129457424 769 255 163 265 52 812 715 609 191 246 849 206 M18923 GO_DOPAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_BINDING.html Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. 3/12 Gene Ontology MF GO:0035240 7.31753618821358e-06 9.61792807668471e-06 80 317.454545454545 266 7.31756028417638e-07 13 3.70755100857243 3.70755100857243 1 19.8499021686059 79 362 897 322 702 63 13 427 266 254 107 207 M17870 GO_SIGNAL_TRANSDUCER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCER_ACTIVITY.html Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 855/2441 Gene Ontology MF GO:0004871 3.26973884031744e-22 5.03539781408886e-20 270 326 267 3.26973884031745e-23 3 2.33379968309504 2.51631071545802 1 48.0628308590521 267 224 801 114 72 241 539 482 434 3 409 208 M17979 GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 212/397 Gene Ontology MF GO:0015077 7.40421372511558e-11 1.80039302158074e-09 295 228.363636363636 267 6.73110338669523e-12 29 2.68589210689846 -2.53046942176087 -1 25.0648055347335 277 370 29 120 220 291 295 180 267 43 420 209 M18019 GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 20/21 Gene Ontology MF GO:0030676 2.99096669900681e-07 9.30984999064807e-07 640 351.181818181818 267 2.71906100512534e-08 119 2.01399521319048 -2.337715014632 -1 12.9624188022318 640 119 215 171 267 639 581 511 130 179 411 210 M18710 GO_KINESIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_BINDING.html Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. 49/60 Gene Ontology MF GO:0019894 2.99217723353598e-07 9.30984999064807e-07 730 389 268 2.72016149136025e-08 56 2.44564053841361 -1.66655664372365 -1 15.7405627959515 727 56 175 219 268 918 835 160 94 295 532 211 M18838 GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY.html Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. 22/31 Gene Ontology MF GO:0030159 1.376807061021e-06 2.42271956650013e-06 265 272.545454545455 268 1.25164356605188e-07 93 3.04867071115387 3.94959085347094 1 18.2704128413799 262 314 152 214 515 318 290 343 93 268 229 212 M19172 GO_MACROMOLECULAR_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_BINDING.html Interacting selectively and non-covalently with any macromolecular complex. 1499/1921 Gene Ontology MF GO:0044877 2.27244866424688e-07 8.67813463409488e-07 180 344.818181818182 269 2.27244889662794e-08 97 1.95541686403817 2.17140634613449 1 12.6490787681267 178 218 920 522 235 192 389 97 409 364 269 213 M18141 GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. 9/14 Gene Ontology MF GO:0015172 5.19116611261584e-07 1.22409576110973e-06 285 344.727272727273 270 5.19116732528549e-08 145 2.59973241995998 2.58916511800302 1 16.4025290434182 285 350 829 190 392 248 145 620 261 270 202 214 M18059 GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. 8/19 Gene Ontology MF GO:0015269 1.32157502091214e-07 8.2820001624993e-07 820 353.545454545455 271 1.32157509950737e-08 7 3.54468823001523 -2.48594256139902 -1 23.0064178266971 632 194 817 88 127 383 271 322 7 232 816 215 M17875 GO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_BINDING.html Interacting selectively and non-covalently with a SMAD signaling protein. 97/113 Gene Ontology MF GO:0046332 3.68180686089847e-07 1.02161848032138e-06 315 247.545454545455 273 3.34709770642443e-08 55 2.24862983427072 2.75740562745442 1 14.375750439435 55 388 192 273 312 119 213 314 369 414 74 216 M18861 GO_PHOSPHATIDIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_BINDING.html Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 18/19 Gene Ontology MF GO:0070300 2.07065895023918e-07 8.48926288617081e-07 350 311 273 1.88241740466491e-08 51 2.55607114760143 3.06959284943796 1 16.5606222735047 349 497 273 503 204 361 187 51 222 529 245 217 M17884 GO_NEUROTRANSMITTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BINDING.html Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 11/32 Gene Ontology MF GO:0042165 6.04332328354809e-07 1.32347671680947e-06 565 333.454545454545 274 5.49393176693505e-08 169 1.90761732433831 -2.1495481613713 -1 11.96674263819 561 169 254 235 403 314 261 634 274 200 363 218 M18027 GO_CARBOXY_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_LYASE_ACTIVITY.html Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. 29/37 Gene Ontology MF GO:0016831 6.80020624187698e-08 8.2820001624993e-07 485 302 275 6.18200586551959e-09 9 1.52733026821192 -1.63910800224538 -1 9.91297126937947 275 407 481 483 9 102 62 246 756 405 96 219 M18061 GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. 65/89 Gene Ontology MF GO:0005546 1.42276342689607e-07 8.2820001624993e-07 835 412 276 1.29342138082519e-08 40 2.24433470356195 2.09903271556342 1 14.5666120378346 833 40 169 57 121 719 737 492 276 244 844 220 M17910 GO_VITAMIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 28/33 Gene Ontology MF GO:0051183 5.82956756875231e-07 1.30124638129901e-06 805 371.090909090909 277 5.29960828497609e-08 21 3.09272085100571 2.63152753181545 1 19.4253405841382 804 98 109 21 396 875 647 277 41 215 599 221 M18345 GO_ION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ion A(out) + ion B(in) = ion A(in) + ion B(out) where ion A and ion B are different types of ion. 30/57 Gene Ontology MF GO:0099516 5.3528333864739e-06 7.40547906433286e-06 285 330.636363636364 279 4.8662240095725e-07 184 1.8632928765072 -1.62806776258762 -1 10.2016506922337 282 301 330 279 654 184 265 219 708 212 203 222 M18446 GO_LIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 8/19 Gene Ontology MF GO:0055102 5.91890443835171e-07 1.3052667544241e-06 210 388.545454545455 280 5.91890601485662e-08 196 1.52338363319032 -1.39977833522011 -1 9.56617387553322 257 206 858 246 418 280 196 764 373 467 209 223 M18632 GO_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BINDING.html Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. 50/96 Gene Ontology MF GO:0042562 5.36916294314255e-08 8.2820001624993e-07 865 356.181818181818 280 4.88105734016229e-09 4 2.30077741301254 2.43542021924316 1 14.9329474199206 863 58 156 185 4 724 587 280 556 174 331 224 M18477 GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 34/44 Gene Ontology MF GO:0046915 3.16181659774376e-07 9.48544979323128e-07 110 368.181818181818 281 2.87437913832433e-08 106 1.59921954888726 -1.73964994016678 -1 10.279001047273 140 477 544 742 281 106 106 215 711 585 143 225 M18361 GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. 11/19 Gene Ontology MF GO:0015114 2.80635456389636e-06 4.30742793528278e-06 355 326.272727272727 283 2.55123467612066e-07 132 2.0502789571364 1.84675398748015 1 11.7403251840499 283 186 270 353 594 230 132 354 602 201 384 226 M18514 GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. 9/12 Gene Ontology MF GO:0008970 2.8824800238107e-07 9.30984999064807e-07 340 335.545454545455 283 2.88248039770186e-08 53 3.07996666676695 -3.07446253158205 -1 19.8231955051865 340 195 864 341 283 292 188 644 220 271 53 227 M18649 GO_CARGO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARGO_RECEPTOR_ACTIVITY.html Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis. 54/78 Gene Ontology MF GO:0038024 6.1211653969839e-08 8.2820001624993e-07 45 295.363636363636 283 5.56469597026909e-09 43 3.49456572392423 3.31559489811955 1 22.6811030500203 293 44 43 73 436 310 283 895 205 96 571 228 M18902 GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). 8/13 Gene Ontology MF GO:0005451 5.2073699872376e-06 7.25733011796009e-06 260 379.727272727273 283 5.20738218979383e-07 45 1.79529982466918 -1.41753719376272 -1 9.84619858399516 258 358 894 283 663 203 45 179 858 338 98 229 M18976 GO_MHC_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 41/83 Gene Ontology MF GO:0042287 4.61446585583602e-07 1.17136440955838e-06 125 289.545454545455 283 4.19496983973941e-08 35 1.79999608152233 -1.19972560330126 -1 11.3934743901418 123 68 320 403 343 35 123 774 539 283 174 230 M18935 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION.html Any protein binding that is involved in cell-cell adhesion. 13/15 Gene Ontology MF GO:0098632 2.97124493681487e-07 9.30984999064807e-07 265 412.363636363636 284 2.7011321255465e-08 134 2.37737201164711 -1.97587247077574 -1 15.3011747462874 693 437 284 217 265 709 499 260 776 262 134 231 M18162 GO_SEROTONIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_ACTIVITY.html Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. 3/14 Gene Ontology MF GO:0099589 2.90922685019695e-07 9.30984999064807e-07 460 373.181818181818 287 2.90922723105906e-08 1 5.12752597890555 4.33509176396581 1 33.0016414940602 460 217 831 13 287 428 448 888 1 252 280 232 M18068 GO_PROTEIN_KINASE_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_BINDING.html Interacting selectively and non-covalently with any subunit of protein kinase A. 41/48 Gene Ontology MF GO:0051018 3.20054105639307e-07 9.50043708585968e-07 290 302.454545454545 288 2.90958320182284e-08 207 2.19053397898349 2.88602636407491 1 14.0780791860051 271 289 282 278 288 251 294 349 371 447 207 233 M18628 GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 77/82 Gene Ontology MF GO:0005089 1.63797587325099e-07 8.2829858135462e-07 165 435.090909090909 288 1.48906908654905e-08 27 2.00631525293158 -2.22698729444404 -1 13.0216615378657 896 27 164 163 157 841 763 841 288 81 565 234 M17947 GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 14/21 Gene Ontology MF GO:0008308 3.20183024340703e-07 9.50043708585968e-07 60 297.090909090909 289 2.91075519035842e-08 56 2.13526225062496 -1.62715595267301 -1 13.7228598956643 272 509 421 194 289 346 352 60 56 490 279 235 M18383 GO_RECEPTOR_AGONIST_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_AGONIST_ACTIVITY.html Interacts with receptors such that the proportion of receptors in the active form is increased. 8/18 Gene Ontology MF GO:0048018 6.03169609476835e-07 1.32347671680947e-06 265 290.909090909091 289 6.03169773193007e-08 70 2.57248197278854 -3.11261122969124 -1 16.13752989364 263 355 851 92 424 289 70 103 298 160 295 236 M18409 GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. 10/15 Gene Ontology MF GO:0048531 5.10981322796069e-07 1.22389859342437e-06 125 263.636363636364 289 4.64528583162541e-08 29 2.55742043944629 -2.53956635771532 -1 16.1357603425216 121 448 289 470 364 142 29 95 354 436 152 237 M18842 GO_MYOSIN_V_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_V_BINDING.html Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. 18/22 Gene Ontology MF GO:0031489 3.49747396792059e-06 5.21236442961069e-06 530 330.727272727273 290 3.17952684370938e-07 82 1.96453098157719 -1.94465173227769 -1 11.0756896333688 471 133 290 142 610 528 521 214 82 528 119 238 M18965 GO_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. 71/315 Gene Ontology MF GO:0003823 3.2092439645646e-07 9.50043708585968e-07 210 376.545454545455 290 2.91749493882935e-08 151 2.0452442764554 -1.84956862545511 -1 13.1443340950053 210 540 235 475 290 151 327 878 637 228 171 239 M17861 GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. 25/32 Gene Ontology MF GO:0035250 3.11911452166405e-07 9.47817595535048e-07 685 432.090909090909 292 2.83555905807795e-08 117 3.0525605054349 -2.69864467150397 -1 19.6214537484332 681 117 159 129 277 711 693 557 228 292 909 240 M19156 GO_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. 867/1395 Gene Ontology MF GO:0005215 1.49734979896619e-09 3.21756096335991e-08 310 311.727272727273 293 1.49734979997512e-10 22 2.2281036854828 -2.1167601515148 -1 17.8153673186237 308 225 918 293 145 250 412 172 314 22 370 241 M18602 GO_DRUG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_BINDING.html Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 120/211 Gene Ontology MF GO:0008144 5.22784612262893e-07 1.22602279627135e-06 165 341.181818181818 294 4.75258851356284e-08 38 2.22631787548821 2.29023898259637 1 14.0449158204491 162 727 158 779 373 38 268 439 364 151 294 242 M19061 GO_GAMMA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_CATENIN_BINDING.html Interacting selectively and non-covalently with the gamma subunit of the catenin complex. 15/21 Gene Ontology MF GO:0045295 5.3049803655458e-07 1.23471079540663e-06 145 313.181818181818 294 4.82271058615015e-08 104 3.15045736133296 4.15421095750439 1 19.8646191213524 294 144 120 340 376 329 651 144 730 104 213 243 M17964 GO_CARBOHYDRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BINDING.html Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. 183/328 Gene Ontology MF GO:0030246 5.11797826027627e-08 8.2820001624993e-07 470 381.727272727273 296 4.65270761758051e-09 3 2.34975205041462 2.62090549186629 1 15.2508120773733 467 252 55 296 3 784 878 231 517 70 646 244 M18802 GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. 49/61 Gene Ontology MF GO:0005548 4.23447383437208e-07 1.11129935559625e-06 160 337.181818181818 296 3.84952240855204e-08 116 2.06352955851222 -1.83575091243862 -1 13.1119114344584 158 471 301 691 331 116 201 238 675 296 231 245 M18808 GO_POTASSIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_BINDING.html Interacting selectively and non-covalently with potassium (K+) ions. 12/25 Gene Ontology MF GO:0030955 3.9452013836301e-06 5.78629536265749e-06 300 259.636363636364 296 3.58655314406581e-07 25 2.1838790263667 -2.55390813386431 -1 12.2066083075755 311 178 296 110 620 298 103 25 359 505 51 246 M19095 GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a G-protein coupled receptor. 215/333 Gene Ontology MF GO:0001664 2.12962936152298e-07 8.48926288617081e-07 325 306.454545454545 297 1.93602687970361e-08 48 2.36928894359626 2.55399151769162 1 15.3504720548478 322 373 52 297 210 99 328 870 580 48 192 247 M18038 GO_ADENYLYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an adenylyl group to an acceptor. 30/34 Gene Ontology MF GO:0070566 4.19401878013621e-06 6.0740961643352e-06 125 298.545454545455 298 3.8127516141075e-07 39 1.60483015726734 -1.91053156432768 -1 8.9339585122156 122 298 504 438 629 54 39 253 448 432 67 248 M18240 GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other. 13/17 Gene Ontology MF GO:0042887 7.29491753179292e-06 9.60185726406932e-06 190 316.545454545455 298 6.63176520083193e-07 79 2.62154004541747 -2.04705908557343 -1 14.0375259749051 186 516 298 435 693 129 79 181 511 370 84 249 M18251 GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a monosaccharide from one side of a membrane to the other. 16/25 Gene Ontology MF GO:0015145 2.06846114600843e-06 3.3648910192109e-06 560 332.181818181818 298 1.88042099163458e-07 12 3.01462332121797 -2.97178466717391 -1 17.6073901607548 783 134 101 12 558 500 542 298 47 122 557 250 M19019 GO_NEUROTROPHIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neurotrophin receptor. 19/21 Gene Ontology MF GO:0005165 2.67688921328219e-06 4.1500765655583e-06 220 304.181818181818 298 2.43353860949128e-07 127 2.52128445843641 3.23363549558337 1 14.4808875666813 219 319 229 383 588 254 298 127 221 404 304 251 M18052 GO_VIRUS_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRUS_RECEPTOR_ACTIVITY.html Combining with a virus component and mediating entry of the virus into the cell. 70/110 Gene Ontology MF GO:0001618 1.82608396866778e-07 8.37618242795071e-07 255 337 300 1.66007647294522e-08 98 2.04175001648163 1.99571582682506 1 13.2410574138586 252 469 191 344 179 98 300 658 654 143 419 252 M19021 GO_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. 369/493 Gene Ontology MF GO:0005543 1.07730270379001e-07 8.2820001624993e-07 475 323.636363636364 300 9.7936614231245e-09 63 1.90338719340782 -1.85328971807401 -1 12.3537286093214 475 238 257 128 63 367 756 323 437 216 300 253 M18452 GO_CYCLIC_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 26/43 Gene Ontology MF GO:0030551 8.78653967843768e-07 1.72372880315847e-06 35 314.727272727273 301 7.98776653425421e-08 31 2.66022128327562 3.0842979297016 1 16.3621579457353 78 680 259 643 456 33 31 301 528 323 130 254 M19124 GO_EPHRIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ephrin receptor. 38/43 Gene Ontology MF GO:0046875 3.40451116933467e-07 9.7091614829174e-07 150 300.363636363636 301 3.09501063289511e-08 132 2.28847003178594 2.86580623578985 1 14.6844430152988 415 290 193 132 301 440 445 149 150 322 467 255 M18015 GO_I_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_SMAD_BINDING.html Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. 17/18 Gene Ontology MF GO:0070411 3.41559039128557e-07 9.71078622014727e-07 235 286.545454545455 302 3.10508265597284e-08 42 1.96128752553891 2.59032980310231 1 12.5848560408222 232 428 387 59 302 456 507 106 42 422 211 256 M17891 GO_BETA_2_MICROGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_2_MICROGLOBULIN_BINDING.html Interacting selectively and non-covalently with beta-2-microglobulin. 24/41 Gene Ontology MF GO:0030881 6.13559062277233e-06 8.28842943778017e-06 15 363.454545454545 304 5.57782521310678e-07 15 1.46801884728721 -1.24757484061334 -1 7.96086084815626 15 304 424 684 674 64 109 201 861 406 256 257 M18026 GO_PROTEIN_LIPID_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_BINDING.html Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. 23/37 Gene Ontology MF GO:0071814 3.37112074462028e-07 9.70378681629016e-07 330 285.363636363636 305 3.06465569198775e-08 108 3.226403064803 3.47146553324562 1 20.7037141817832 326 310 108 468 298 420 249 116 305 194 345 258 M18360 GO_RECEPTOR_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. 25/40 Gene Ontology MF GO:0030546 1.17979528139837e-07 8.2820001624993e-07 540 332.636363636364 306 1.07254122242484e-08 78 1.94638327917921 -1.97948557279211 -1 12.6327901154501 536 306 287 106 78 489 420 191 616 154 476 259 M18862 GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. 27/43 Gene Ontology MF GO:0005310 2.70894612611259e-06 4.18572946576594e-06 820 404.636363636364 306 2.46268132886341e-07 53 2.35395717657828 -2.7553554061929 -1 13.5105179374231 816 102 188 53 590 755 632 306 255 153 601 260 M19054 GO_DOPAMINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a dopamine receptor. 26/31 Gene Ontology MF GO:0050780 2.83522895778442e-07 9.30984999064807e-07 455 326.090909090909 308 2.57748120288355e-08 106 1.83155802630511 -1.9178660132655 -1 11.7882215032926 453 106 308 152 258 394 500 250 620 324 222 261 M17853 GO_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently with a polymer of ubiqutin. 44/46 Gene Ontology MF GO:0031593 2.87492401826197e-07 9.30984999064807e-07 260 417.545454545455 309 2.61356763086582e-08 214 1.15293488437981 -1.18204959749274 -1 7.42048555071528 251 474 663 594 260 259 256 548 214 765 309 262 M17933 GO_STEROID_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_DEHYDROGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. 23/53 Gene Ontology MF GO:0016229 6.27547800428246e-07 1.3569934439499e-06 170 361.090909090909 309 5.70498163123364e-08 155 1.87885701713683 -2.15982455314078 -1 11.7645474033238 166 309 334 687 411 170 155 224 753 511 252 263 M19217 GO_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 19/37 Gene Ontology MF GO:0005272 3.39946684790133e-07 9.7091614829174e-07 425 273.363636363636 310 3.09042488471928e-08 43 3.37556679577218 3.54378418544035 1 21.6600264169398 421 123 78 43 300 425 322 407 310 85 493 264 M18302 GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. 24/37 Gene Ontology MF GO:0015175 9.91306061209293e-08 8.2820001624993e-07 620 383.454545454545 311 9.01187368979018e-09 49 2.60261438263499 2.84897267766724 1 16.8919880590154 617 109 157 180 49 566 473 755 311 131 870 265 M19073 GO_RECEPTOR_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_REGULATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. 34/55 Gene Ontology MF GO:0030545 3.65612032409467e-07 1.01754674080225e-06 585 363.272727272727 311 3.32374630154139e-08 91 1.90494322364055 -2.06408666798955 -1 12.1820475873228 585 91 275 102 311 542 494 302 631 125 538 266 M18407 GO_FIBROBLAST_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with a fibroblast growth factor. 35/55 Gene Ontology MF GO:0017134 6.62778370662998e-07 1.40138950684808e-06 105 298.272727272727 312 6.02525973030557e-08 14 2.06065356084649 2.5219611107641 1 12.8721294259447 103 615 312 368 423 103 93 75 487 688 14 267 M18486 GO_SCAFFOLD_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAFFOLD_PROTEIN_BINDING.html Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. 60/84 Gene Ontology MF GO:0097110 5.08789608095536e-07 1.22389859342437e-06 315 287.727272727273 312 4.62536114329392e-08 41 3.12171099932259 3.80754140781197 1 19.6960896099175 312 41 49 207 417 477 584 122 541 69 346 268 M19125 GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a chloride channel. 14/19 Gene Ontology MF GO:0017081 4.90122216550952e-06 6.90355073312622e-06 330 326.181818181818 312 4.45566644056801e-07 65 1.40733335229151 -1.24181647451514 -1 7.75101953962039 328 162 509 411 645 183 148 65 312 590 235 269 M18892 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. 39/49 Gene Ontology MF GO:0001105 1.25285677258861e-07 8.2820001624993e-07 315 367.272727272727 314 1.13896076721486e-08 72 2.17769310697275 2.44317127210239 1 14.1340818672073 314 72 279 245 87 312 432 887 441 465 506 270 M18924 GO_SH3_SH2_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_SH2_ADAPTOR_ACTIVITY.html Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). 45/69 Gene Ontology MF GO:0005070 4.95115567259972e-07 1.21672017060695e-06 360 318.545454545455 314 4.50105162442744e-08 176 1.85050157539496 -1.96357509430094 -1 11.6805785494893 357 283 333 226 355 303 423 541 176 314 193 271 M17916 GO_PROTEIN_SELF_ASSOCIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SELF_ASSOCIATION.html Interacting selectively and non-covalently with a domain within the same polypeptide. 56/71 Gene Ontology MF GO:0043621 3.71730286676169e-07 1.02225828835946e-06 655 379.181818181818 315 3.37936681351657e-08 34 2.57905833290836 2.74318128603211 1 16.4874700911713 651 46 137 34 315 625 533 502 240 166 922 272 M18408 GO_ADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_BINDING.html Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. 45/67 Gene Ontology MF GO:0043531 7.60540040875849e-07 1.54448131377865e-06 385 303.272727272727 315 6.91400276176985e-08 73 2.44852221479023 2.74118051202151 1 15.1846693731005 384 473 269 111 441 381 315 192 73 476 221 273 M18191 GO_CATION_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). 17/28 Gene Ontology MF GO:0015491 6.92964105720986e-05 7.66824950522384e-05 280 376.181818181818 316 6.29987212656623e-06 112 2.38388720480557 -1.80006797113617 -1 10.4693986390432 278 500 316 355 829 276 262 226 649 335 112 274 M18875 GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. 12/13 Gene Ontology MF GO:0008484 4.18169758450937e-08 7.4305549386282e-07 920 440.636363636364 317 3.80154333090355e-09 1 2.93304252648101 -1.73459714035221 -1 19.1840662470497 920 171 252 135 1 911 778 673 58 317 631 275 M18817 GO_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_A2_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. 20/33 Gene Ontology MF GO:0004623 8.65316531173645e-07 1.70874952132735e-06 320 310.454545454545 318 7.86651701386417e-08 11 2.73899750150689 -2.40918448269096 -1 16.8577646400357 318 559 243 473 454 231 257 175 326 368 11 276 M18212 GO_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_ACTIVITY.html Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 13/14 Gene Ontology MF GO:0004707 3.69841155170425e-06 5.46773163803956e-06 160 299.636363636364 319 3.36219797191303e-07 12 1.41435028501222 -1.71214393734721 -1 7.94251123976782 159 444 470 319 613 111 68 58 406 636 12 277 M18378 GO_PALMITOYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. 29/36 Gene Ontology MF GO:0016409 1.01164001653063e-06 1.90483704525857e-06 320 349.272727272727 319 9.19673165199816e-08 198 1.39359380190488 -1.55764479290733 -1 8.5070138233495 319 299 554 396 476 321 234 282 198 473 290 278 M18606 GO_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. 38/49 Gene Ontology MF GO:0008374 1.63408313380507e-06 2.77044553327686e-06 310 349 321 1.48553122504199e-07 70 1.53813439707957 -1.56417023587033 -1 9.12229258319091 310 399 467 561 532 293 239 70 387 321 260 279 M18860 GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. 16/18 Gene Ontology MF GO:0034979 5.1178521322343e-07 1.22389859342437e-06 305 371.181818181818 323 4.65259392981709e-08 155 1.1089337760107 -1.14920284599559 -1 6.99669294009537 302 155 625 453 365 211 323 265 445 700 239 280 M18458 GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. 13/19 Gene Ontology MF GO:0005229 1.87228593135545e-06 3.10034444547031e-06 335 290.818181818182 324 1.70207956795073e-07 44 2.70763339500402 -2.50683348510315 -1 15.917120066229 332 167 185 436 548 324 354 234 203 372 44 281 M19145 GO_PROTEIN_PHOSPHATASE_2A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_2A_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. 40/44 Gene Ontology MF GO:0051721 8.3504032388707e-06 1.07462013826135e-05 55 331.545454545455 324 7.59130448558691e-07 51 2.13103559924933 2.34994143840257 1 11.2998209244182 51 550 408 332 710 123 73 141 324 760 175 282 M18671 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. 15/29 Gene Ontology MF GO:0016701 1.20811148216246e-06 2.18881374415316e-06 790 391.818181818182 325 1.09828376871565e-07 103 2.42413090116502 -3.1442701154773 -1 14.6416710922554 787 145 151 177 498 602 325 463 186 103 873 283 M18552 GO_MODIFIED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a modified amino acid. 73/101 Gene Ontology MF GO:0072341 4.11067453732847e-07 1.1000118971979e-06 330 301.181818181818 326 3.73697755036677e-08 121 2.24249043920929 2.31210929986867 1 14.2596606694188 225 606 228 151 326 121 331 355 503 326 141 284 M18590 GO_NEUROPILIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPILIN_BINDING.html Interacting selectively and non-covalently with a member of the neuropilin family. 15/15 Gene Ontology MF GO:0038191 1.9229214299077e-06 3.15591367892489e-06 250 368.727272727273 327 1.74811191877202e-07 132 2.85748661103326 3.32252520185874 1 16.7745219415141 248 327 132 301 554 438 468 199 696 147 546 285 M18516 GO_HMG_BOX_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HMG_BOX_DOMAIN_BINDING.html Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. 9/22 Gene Ontology MF GO:0071837 1.96830934522898e-06 3.21896961945413e-06 480 401.272727272727 329 1.96831108863991e-07 197 2.42806142615798 3.6741266403655 1 14.2313714331463 480 197 865 247 564 454 329 307 264 272 435 286 M19115 GO_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 1297/2125 Gene Ontology MF GO:0005102 7.17877216473306e-22 7.37020608912594e-20 330 340.818181818182 329 7.17877216473306e-23 4 2.33198412096088 2.60057905979355 1 47.6137077050354 329 219 916 113 109 189 502 544 402 4 422 287 M17889 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. 22/26 Gene Ontology MF GO:0080025 1.60124032065357e-05 1.9342687985192e-05 325 415 330 1.45568361380362e-06 151 2.23141062680905 2.20899920236416 1 11.224205319456 323 626 456 330 758 387 324 288 151 680 242 288 M19094 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 15/18 Gene Ontology MF GO:0004675 7.41798405370932e-06 9.71515511470032e-06 65 306.363636363636 330 6.74364460533376e-07 62 2.13250427166856 2.42595112369962 1 11.407298241735 276 507 331 439 694 330 125 63 99 444 62 289 M18787 GO_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 71/84 Gene Ontology MF GO:0019209 1.16874122503879e-07 8.2820001624993e-07 530 371.727272727273 332 1.062492079207e-08 75 2.03840172371644 -1.89661604919357 -1 13.2300260094501 529 274 305 150 75 362 508 815 320 419 332 290 M19227 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. 48/72 Gene Ontology MF GO:0043028 2.20052991514855e-07 8.64228135305932e-07 565 383 332 2.00048194114052e-08 86 2.18112565185777 -2.60537629310779 -1 14.1133150866385 565 664 332 318 215 495 716 86 204 526 92 291 M18823 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. 13/20 Gene Ontology MF GO:0016641 3.08560935795722e-06 4.69703961573718e-06 455 391.909090909091 333 2.80510335062384e-07 119 3.59398930187565 3.9913311984559 1 20.4356999610688 451 333 119 206 599 661 824 386 224 205 303 292 M18054 GO_NUCLEOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_BINDING.html Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. 64/80 Gene Ontology MF GO:0031491 6.18963819065484e-06 8.33706368537182e-06 270 391.363636363636 335 5.62695964099689e-07 168 1.80954591398108 1.84576997193898 1 9.80800834263599 168 544 528 374 676 269 335 198 270 668 275 293 M18977 GO_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 51/126 Gene Ontology MF GO:0005267 1.89476128851288e-08 3.50151886117181e-07 710 369.454545454545 335 1.72251027711964e-09 42 3.43963356365436 3.43013469037705 1 23.696960735402 706 50 42 89 335 615 711 524 254 64 674 294 M18021 GO_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 87/105 Gene Ontology MF GO:0019210 1.01981749511611e-07 8.2820001624993e-07 405 347.545454545455 336 9.27106856718277e-09 54 2.27237028092465 2.59993303062959 1 14.7485739607319 404 656 265 564 54 285 514 313 336 356 76 295 M18051 GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. 8/11 Gene Ontology MF GO:0019203 8.6086174208436e-05 9.39121900455666e-05 140 411.545454545455 337 8.60895092634943e-06 137 1.52502005211606 -1.52502005211606 -1 6.55422329653572 137 521 816 493 844 153 172 183 665 337 206 296 M18882 GO_HYALURONIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONIC_ACID_BINDING.html Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. 14/24 Gene Ontology MF GO:0005540 9.74660923827465e-06 1.23537269357555e-05 175 336.363636363636 337 8.86059310792772e-07 171 2.74523249512188 3.26761336955081 1 14.3792332210234 171 332 184 378 723 337 347 344 216 234 434 297 M18063 GO_ANION_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). 32/65 Gene Ontology MF GO:0015296 4.43449549742354e-07 1.1445457652568e-06 595 372.090909090909 338 4.03136035570553e-08 42 2.61012681373627 2.25467624641243 1 16.549396291048 595 70 59 86 338 618 887 460 158 42 780 298 M18097 GO_SERINE_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 124/379 Gene Ontology MF GO:0017171 7.37616845997068e-11 1.80039302158074e-09 390 351.363636363636 339 6.70560769110724e-12 28 3.1273626799799 -3.38463201726454 -1 29.1846193159358 389 267 28 426 118 509 600 842 287 60 339 299 M18449 GO_ATPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_BINDING.html Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. 92/113 Gene Ontology MF GO:0051117 4.45961142078268e-07 1.14782199242429e-06 220 343.727272727273 339 4.05419302253548e-08 62 1.64377296495259 -1.55789515753746 -1 10.4200928019679 218 537 482 494 339 62 189 286 668 344 162 300 M17973 GO_PROTEIN_HETERODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETERODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. 388/584 Gene Ontology MF GO:0046982 4.47353529977655e-07 1.14820739360931e-06 430 327.272727272727 340 4.06685109948792e-08 132 2.03086168235319 2.22067024045057 1 12.8735837264961 430 365 199 300 340 132 519 418 393 184 320 301 M19026 GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY.html Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 6/26 Gene Ontology MF GO:0001637 8.12094138259619e-07 1.62771146150084e-06 460 384.363636363636 340 8.1209443503337e-08 190 3.4156719057659 4.29308730289988 1 21.0994226765102 320 459 906 434 458 228 190 468 340 226 199 302 M18952 GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. 64/83 Gene Ontology MF GO:0070491 1.71052853104882e-06 2.87368793216202e-06 265 392.090909090909 341 1.55502714637126e-07 177 1.38566065268298 1.41131431639853 1 8.19451131949288 261 543 665 255 540 177 204 285 341 669 373 303 M17945 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). 11/29 Gene Ontology MF GO:0005104 3.55672818191297e-05 4.08250539141315e-05 65 360.909090909091 342 3.23344153149812e-06 5 3.90518189545978 3.90518189545978 1 18.2914561935509 62 710 247 571 838 69 27 522 342 577 5 304 M18466 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. 29/46 Gene Ontology MF GO:0043027 1.86010800128004e-06 3.08610986588622e-06 550 349.363636363636 342 1.69100870364544e-07 13 2.48849639762741 -3.30678493438863 -1 14.6342064377808 546 408 204 304 546 565 452 284 179 342 13 305 M18904 GO_TETRAPYRROLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BINDING.html Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. 76/185 Gene Ontology MF GO:0046906 1.24488593043313e-07 8.2820001624993e-07 135 410 342 1.13171454625083e-08 33 2.46341235314357 -2.44055093046514 -1 15.9885121423334 803 33 134 342 85 622 669 530 268 135 889 306 M18357 GO_IMMUNOGLOBULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. 9/121 Gene Ontology MF GO:0034987 2.22225908737679e-06 3.57107373345419e-06 325 355.727272727273 343 2.22226130967587e-07 54 3.07953823367804 2.74254139063261 1 17.9016557431411 325 352 848 100 575 343 393 339 54 498 86 307 M19191 GO_HISTONE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 29/49 Gene Ontology MF GO:0035173 5.35702463328509e-06 7.40547906433286e-06 85 347.272727272727 343 4.87003425249502e-07 34 1.63016630406307 1.78367798645652 1 8.92526706466278 82 479 490 538 655 83 34 241 562 343 313 308 M18253 GO_CAMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BINDING.html Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). 18/29 Gene Ontology MF GO:0030552 5.99651214624046e-06 8.14820179871498e-06 105 403.909090909091 344 5.45138953720006e-07 51 2.41570858926634 2.78816554213392 1 13.1191555857557 101 817 344 740 670 71 51 338 695 458 158 309 M18276 GO_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_ACTIVITY.html Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 9/27 Gene Ontology MF GO:0008066 2.90823897425357e-07 9.30984999064807e-07 810 465.272727272727 344 2.90823935485706e-08 68 3.03906793300314 -3.46678574337713 -1 19.5599641786387 809 344 840 229 286 846 813 605 68 119 159 310 M18180 GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY.html Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. 19/21 Gene Ontology MF GO:0004029 2.05935357518385e-07 8.48926288617081e-07 485 354.181818181818 345 1.87213978904886e-08 132 2.47539810932377 -2.70257141251841 -1 16.0379467036805 483 132 174 345 202 370 398 758 313 248 473 311 M18417 GO_CARBOHYDRATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. 17/20 Gene Ontology MF GO:0019200 1.50937929930896e-07 8.2820001624993e-07 300 430.363636363636 346 1.37216309351336e-08 135 1.33656015333985 -1.47371715081267 -1 8.67479819791425 297 695 534 885 135 215 346 228 669 591 139 312 M18914 GO_CXCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CXCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. 11/15 Gene Ontology MF GO:0045236 9.30282961435727e-06 1.18562959498843e-05 350 393.727272727273 346 8.45715359286659e-07 187 3.53929254229058 -3.8207511768971 -1 18.6058514836586 346 447 203 221 719 488 434 187 682 267 337 313 M18813 GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS.html Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 54/63 Gene Ontology MF GO:0016879 2.29525486296894e-07 8.72763577523992e-07 290 399.545454545455 347 2.0865955476658e-08 88 1.53186853585512 -1.51729235588563 -1 9.90521686930281 290 545 577 786 221 133 88 336 486 586 347 314 M19151 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS.html Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. 114/156 Gene Ontology MF GO:0016810 5.12606878414752e-07 1.22389859342437e-06 270 342.636363636364 347 4.6600636168527e-08 142 2.06796160238573 -1.97118265408538 -1 13.0475736056138 472 268 347 266 366 296 469 396 142 469 278 315 M18451 GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. 34/54 Gene Ontology MF GO:0052742 7.70679715480401e-07 1.55822331970217e-06 490 388.818181818182 349 7.00618168596858e-08 95 1.9970333117396 -2.00089170871499 -1 12.3765323985069 486 295 349 414 444 342 643 327 95 717 165 316 M18075 GO_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_BINDING.html Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. 721/914 Gene Ontology MF GO:0019900 1.65744898016865e-07 8.2829858135462e-07 180 354.454545454545 350 1.65744910378983e-08 172 1.87902947797601 2.11603541380355 1 12.195533819917 350 230 818 172 178 308 405 453 356 178 451 317 M18621 GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR.html Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. 10/11 Gene Ontology MF GO:0016884 9.7201278636286e-06 1.23370853653748e-05 210 380.272727272727 350 8.83651891795579e-07 49 1.57233383900921 -1.75119231962495 -1 8.23669702862879 209 574 483 350 722 344 146 308 49 640 358 318 M19214 GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. 24/25 Gene Ontology MF GO:0070273 2.57860850490457e-06 4.05209907913574e-06 270 388.454545454545 350 2.34419229753007e-07 117 1.87389667201831 2.26898328640811 1 10.7833929719437 269 682 492 454 580 253 117 350 160 615 301 319 M18374 GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY.html Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. 10/12 Gene Ontology MF GO:0031543 7.22866435370724e-06 9.52822519661268e-06 195 391.181818181818 351 6.57153464131596e-07 29 2.57613743604722 2.76743422695381 1 13.8036003216723 192 519 350 351 852 393 809 29 317 435 56 320 M19153 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the platelet-derived growth factor receptor. 17/18 Gene Ontology MF GO:0005161 6.36621926784764e-06 8.51186476447995e-06 205 420.818181818182 351 5.78748880916395e-07 204 1.9044379001796 1.77811001028899 1 10.3040223632175 204 495 307 443 682 323 305 351 760 256 503 321 M17854 GO_COFACTOR_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORTER_ACTIVITY.html Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. 22/23 Gene Ontology MF GO:0051184 2.59406703418601e-07 9.23961214138929e-07 735 428.545454545455 352 2.3582430364164e-08 43 2.74591241314711 -2.45397862870809 -1 17.6828023171679 733 315 234 136 241 606 511 801 43 352 742 322 M18228 GO_S100_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_S100_PROTEIN_BINDING.html Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. 17/20 Gene Ontology MF GO:0044548 1.60378881076582e-07 8.2820001624993e-07 160 312 352 1.45798993425565e-08 101 1.68327144631488 -1.67341658033552 -1 10.9250908437118 160 423 415 357 153 196 101 523 550 202 352 323 M18145 GO_ADRENERGIC_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an adrenergic receptor. 26/30 Gene Ontology MF GO:0031690 1.86096598755009e-07 8.38796376827457e-07 770 454.181818181818 354 1.6917874045164e-08 184 1.74283706565117 -1.733913859857 -1 11.3014260182438 766 302 354 325 184 856 524 237 739 217 492 324 M18704 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 31/38 Gene Ontology MF GO:0097472 4.08600502142196e-06 5.96440543411357e-06 270 370.909090909091 354 3.71455691843337e-07 92 1.90508803422411 2.19534444156934 1 10.6215607724707 270 409 417 354 624 347 486 92 307 506 268 325 M18697 GO_CHEMOATTRACTANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOATTRACTANT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. 22/29 Gene Ontology MF GO:0042056 6.40437095791555e-07 1.37256281552322e-06 355 334.090909090909 355 5.82215711116225e-08 134 2.96041058326788 2.89977703342072 1 18.5210926361008 253 488 153 471 414 141 134 404 509 353 355 326 M18540 GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of potassium ions (K+) from one side of a membrane to the other. 68/152 Gene Ontology MF GO:0015079 4.91612057450704e-10 1.08154652639155e-08 35 418.454545454545 356 4.46920052327781e-11 32 3.12886182600229 3.17362336372504 1 26.5985786579474 822 32 33 82 356 801 900 384 260 35 898 327 M18421 GO_ADENOSINE_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOSINE_DEAMINASE_ACTIVITY.html Catalysis of the reaction: adenosine + H2O = inosine + NH3. 8/10 Gene Ontology MF GO:0004000 7.20349282071004e-07 1.4957364868171e-06 320 345.454545454545 357 7.20349515577499e-08 1 2.13233683433729 -2.78158700605794 -1 13.2555180071261 317 357 856 525 446 128 54 532 9 575 1 328 M18376 GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS.html Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). 19/20 Gene Ontology MF GO:0016780 1.49983503120796e-05 1.82588612494882e-05 155 413.272727272727 358 1.36349568757166e-06 123 1.10518930463383 -1.21522775114971 -1 5.58874125745082 155 629 623 581 754 195 166 123 358 758 204 329 M17959 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. 94/142 Gene Ontology MF GO:0016616 2.00168191323056e-07 8.48419306341761e-07 240 349 359 1.81971099577699e-08 19 1.7205736475641 -2.02554850474399 -1 11.147962591515 240 19 465 565 196 350 373 276 548 448 359 330 M18523 GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING.html Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. 9/17 Gene Ontology MF GO:0033612 7.22005898827872e-05 7.96101969590637e-05 360 416.272727272727 359 7.22029358063908e-06 110 2.64225116641974 2.40111456608711 1 11.5581807176523 359 346 866 389 835 331 447 151 110 389 356 331 M18701 GO_QUATERNARY_AMMONIUM_GROUP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_BINDING.html Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 22/56 Gene Ontology MF GO:0050997 3.38049519609071e-06 5.06252441035302e-06 210 348.545454545455 359 3.07318217321153e-07 23 1.97854301612577 -2.0189401016324 -1 11.1814341357949 207 625 359 576 607 68 78 114 683 494 23 332 M18721 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY.html Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. 18/21 Gene Ontology MF GO:0030228 3.64531019510567e-05 4.17381241670092e-05 380 382.818181818182 359 3.31397327073524e-06 247 2.42767532498008 3.33899456835577 1 11.3460845398627 264 424 295 359 802 377 248 247 499 380 316 333 M18235 GO_ANTIOXIDANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIOXIDANT_ACTIVITY.html Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. 50/82 Gene Ontology MF GO:0016209 2.88246654417741e-07 9.30984999064807e-07 430 361 360 2.62042447440156e-08 237 2.01038366842433 -1.95179214257087 -1 12.9391742752699 470 281 241 429 261 437 426 360 330 237 499 334 M18365 GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. 7/13 Gene Ontology MF GO:0004859 2.96656374095831e-07 9.30984999064807e-07 365 416.636363636364 362 2.9665641369809e-08 212 1.74436841757674 -1.64510799121059 -1 11.2270540965142 336 212 849 243 294 363 365 882 362 410 267 335 M18459 GO_G_PROTEIN_COUPLED_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PHOTORECEPTOR_ACTIVITY.html Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 4/9 Gene Ontology MF GO:0008020 3.66994395470289e-06 5.43434008677158e-06 625 382.636363636364 362 3.66995001553685e-07 19 2.84286724232047 3.49489390760775 1 15.9726516956068 221 587 859 578 622 220 90 28 623 362 19 336 M18611 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS.html Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). 18/33 Gene Ontology MF GO:0016769 3.94663355244517e-07 1.06941038195288e-06 130 448.545454545455 362 3.58784932767413e-08 39 2.70262537579199 -2.65467713891044 -1 17.2209299976845 817 127 170 126 321 895 799 362 39 379 899 337 M18691 GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. 13/13 Gene Ontology MF GO:0043142 0.000124569098294512 0.000134779680121931 20 351.272727272727 363 1.13251047495197e-05 20 1.45044783146685 1.52807643900505 1 5.99086139995476 20 438 363 412 849 110 99 316 591 373 293 338 M18024 GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING.html A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors. 35/51 Gene Ontology MF GO:0098531 1.32842848012005e-06 2.35147110274123e-06 215 337.818181818182 365 1.20766298387927e-07 31 1.80257504705942 -1.75974721951555 -1 10.8276083502864 213 671 365 510 512 140 251 85 399 539 31 339 M18080 GO_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. 20/27 Gene Ontology MF GO:0016289 3.39349915306562e-07 9.7091614829174e-07 395 385.181818181818 365 3.08499970592077e-08 180 2.04144432212694 -1.89039678731478 -1 13.0993509635504 246 496 393 694 299 288 180 291 392 593 365 340 M18221 GO_PHOSPHOLIPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_BINDING.html Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. 23/29 Gene Ontology MF GO:0043274 1.57288428704783e-06 2.69288126122974e-06 365 387.454545454545 365 1.42989582870772e-07 71 1.63671535557367 1.95210764521601 1 9.72849239661691 362 417 398 365 527 235 71 281 764 595 247 341 M19050 GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. 165/201 Gene Ontology MF GO:0005057 8.30795982734312e-08 8.2820001624993e-07 660 492.636363636364 365 7.55269103734584e-09 27 1.86883175232507 1.95933804739806 1 12.1294502067532 657 259 364 314 27 815 860 656 365 320 782 342 M18023 GO_CYTOSKELETAL_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. 15/18 Gene Ontology MF GO:0008093 3.10270955576085e-07 9.461728150241e-07 590 343.727272727273 366 2.82064544849369e-08 2 1.91213536284402 -1.47500599851222 -1 12.2924904538161 590 139 366 42 276 494 555 635 2 257 425 343 M18432 GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 276/334 Gene Ontology MF GO:0005085 1.80944322217931e-07 8.37618242795071e-07 880 464.090909090909 366 1.64494851909215e-08 116 2.06641646776183 -1.99871254742615 -1 13.4010231123931 877 244 130 203 176 827 720 779 366 116 667 344 M19001 GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. 14/30 Gene Ontology MF GO:0005242 1.01369195680004e-06 1.90483704525857e-06 480 363.181818181818 366 9.21538567162042e-08 46 3.56978292535736 3.02146203885029 1 21.7912843961721 629 154 125 46 477 478 366 643 71 177 829 345 M18445 GO_PYRIDOXAL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDOXAL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. 40/53 Gene Ontology MF GO:0030170 1.54330605106387e-07 8.2820001624993e-07 545 373.727272727273 367 1.40300559938839e-08 73 2.31162066349277 -2.85357504021174 -1 15.0033243799637 544 73 222 430 141 447 520 769 367 310 288 346 M18982 GO_HISTONE_ACETYLTRANSFERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_ACETYLTRANSFERASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone acetyltransferase. 33/38 Gene Ontology MF GO:0035035 8.28499807622636e-07 1.64985737552439e-06 130 375.909090909091 367 7.53181926934748e-08 127 1.97717068732094 2.60574021405743 1 12.2010718099646 127 403 341 456 451 178 137 324 728 623 367 347 M19175 GO_ACID_THIOL_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_THIOL_LIGASE_ACTIVITY.html Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 13/20 Gene Ontology MF GO:0016878 1.64062509603153e-05 1.97645057201191e-05 435 375.181818181818 367 1.49148848266836e-06 27 1.8654666426275 -1.6713323111577 -1 9.36482038210016 433 435 367 228 760 311 254 406 27 552 354 348 M18703 GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 37/96 Gene Ontology MF GO:0005249 1.53032309602036e-07 8.2820001624993e-07 530 349.363636363636 368 1.39120291133624e-08 46 3.56172613700943 3.47093247420551 1 23.1170005437463 528 288 46 212 483 368 454 608 334 57 465 349 M19203 GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. 12/13 Gene Ontology MF GO:0046030 2.71630801235492e-07 9.30984999064807e-07 385 385.090909090909 368 2.46937122521235e-08 177 1.06731363226444 -1.320918051953 -1 6.86941235844542 381 177 514 572 250 315 456 368 322 685 196 350 M18100 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS.html Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). 153/208 Gene Ontology MF GO:0016758 8.69965563784632e-08 8.2820001624993e-07 370 406.090909090909 369 7.90877816533139e-09 31 2.02215097334003 2.24480951074456 1 13.1245522484228 369 262 260 556 31 666 777 456 279 332 479 351 M18638 GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. 20/21 Gene Ontology MF GO:0034236 9.3752988066708e-08 8.2820001624993e-07 370 354.909090909091 369 8.52299927836285e-09 41 1.85314952241977 2.15968046466405 1 12.0276663671707 393 318 369 284 41 373 495 263 497 503 368 352 M18913 GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY.html Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 10/62 Gene Ontology MF GO:0008227 5.18137185873027e-07 1.22409576110973e-06 30 472.454545454545 369 4.71033916275574e-08 27 3.32728691397315 2.37114134779549 1 20.9928998417548 891 338 113 27 369 901 755 625 29 241 908 353 M18207 GO_CALCIUM_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. 64/103 Gene Ontology MF GO:0048306 8.80730424633827e-07 1.72414176347809e-06 315 365.909090909091 371 8.00664342926007e-08 277 1.94636599412599 -1.89226341629591 -1 11.9712488386681 315 277 292 404 457 371 317 399 450 302 441 354 M18286 GO_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. 221/269 Gene Ontology MF GO:0035091 1.69424709822536e-07 8.2829858135462e-07 435 388.727272727273 371 1.54022475336494e-08 165 1.83172701975224 -1.7950094469007 -1 11.8885248719068 509 371 431 232 165 353 700 348 346 431 390 355 M18455 GO_CO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CO_SMAD_BINDING.html Interacting selectively and non-covalently with a common mediator SMAD signaling protein. 13/19 Gene Ontology MF GO:0070410 2.83882707457282e-07 9.30984999064807e-07 375 445.181818181818 371 2.58075221898937e-08 34 2.26186888652022 -1.9920199632246 -1 14.55777664934 845 334 317 143 259 860 611 375 34 371 748 356 M18549 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING.html Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. 25/27 Gene Ontology MF GO:0016922 5.19313353198066e-07 1.22409576110973e-06 210 437.090909090909 372 4.72103159802559e-08 197 1.09641470655964 -1.08152581196434 -1 6.917623391677 206 621 662 602 372 271 197 359 483 736 299 357 M18932 GO_NUCLEOSOMAL_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOMAL_DNA_BINDING.html Interacting selectively and non-covalently with the DNA portion of a nucleosome. 46/61 Gene Ontology MF GO:0031492 1.12115641762978e-05 1.39427796755036e-05 195 417.636363636364 373 1.01923830115385e-06 176 1.79256175829623 1.77332195344151 1 9.28871590646578 195 609 475 373 738 326 523 176 283 632 264 358 M18214 GO_NEUROPEPTIDE_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_HORMONE_ACTIVITY.html The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. 9/29 Gene Ontology MF GO:0005184 4.78400694264321e-07 1.20217323808366e-06 195 376.636363636364 374 4.78400797254601e-08 165 3.46826421590599 3.87296513790073 1 21.9114186374569 229 455 835 477 374 165 195 436 513 192 272 359 M17876 GO_SYNTAXIN_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_1_BINDING.html Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. 20/27 Gene Ontology MF GO:0017075 3.83402957708917e-07 1.04502753074643e-06 325 385.909090909091 375 3.48548204114662e-08 137 1.71365464941094 -1.25872464113519 -1 10.9375983828631 375 487 394 244 318 430 712 325 137 502 321 360 M18648 GO_CARBON_SULFUR_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_SULFUR_LYASE_ACTIVITY.html Catalysis of the elimination of hydrogen sulfide or substituted H2S. 10/13 Gene Ontology MF GO:0016846 1.57376177604336e-06 2.69288126122974e-06 20 319 375 1.43069354711735e-07 16 1.92063766347785 -1.80140217046339 -1 11.4161021634936 406 181 375 223 690 413 713 16 20 438 34 361 M18909 GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a potassium channel. 40/60 Gene Ontology MF GO:0015459 1.74508389369324e-06 2.92111869161695e-06 745 378.181818181818 376 1.58644116175467e-07 49 2.89976450736572 -2.7411154718828 -1 17.1266113624386 741 66 162 49 542 590 861 504 81 188 376 362 M18248 GO_METALLOENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 78/124 Gene Ontology MF GO:0004222 2.99245178270831e-07 9.30984999064807e-07 305 342.545454545455 377 2.7204110815848e-08 85 2.86253138729787 3.43980174197564 1 18.4237444272268 301 467 85 557 269 482 479 170 377 182 399 363 M18490 GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 11/12 Gene Ontology MF GO:0015129 2.31981274646543e-07 8.74900807238389e-07 500 362.909090909091 377 2.10892090098229e-08 88 2.81860838984997 2.02390918218304 1 18.2222142337215 498 175 133 385 223 643 749 567 154 88 377 364 M18527 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS.html Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). 214/288 Gene Ontology MF GO:0016757 1.53514459551968e-07 8.2820001624993e-07 380 424.818181818182 377 1.39558609331e-08 139 1.98651267624066 2.2650585095331 1 12.8932456844419 355 375 323 673 139 608 735 378 296 377 414 365 M18846 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. 22/25 Gene Ontology MF GO:0015215 2.12324445432437e-07 8.48926288617081e-07 455 357.181818181818 377 1.93022241749189e-08 115 1.22091370308352 -1.31818266506382 -1 7.91022068931572 455 115 529 532 208 365 377 233 418 219 478 366 M18568 GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. 26/31 Gene Ontology MF GO:0004683 5.3732362733985e-07 1.24432840015544e-06 310 379.181818181818 378 4.88476144158864e-08 107 1.84347257214418 1.93501405373886 1 11.6170406749814 292 107 306 534 378 306 313 623 432 393 487 367 M18586 GO_ALKALI_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALI_METAL_ION_BINDING.html Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. 19/43 Gene Ontology MF GO:0031420 1.31711901379623e-06 2.34041917066869e-06 510 340.909090909091 378 1.19738163849408e-07 55 2.99776199440697 -2.89305681361785 -1 18.0133386634094 506 126 149 55 510 556 378 662 91 325 392 368 M18363 GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. 16/70 Gene Ontology MF GO:0030594 1.78579020812576e-06 2.97846597889568e-06 425 348.090909090909 379 1.62344696154007e-07 92 2.21965297978273 -2.36484050918838 -1 13.0897303750506 423 141 182 392 544 498 770 379 211 92 197 369 M19198 GO_OXIDIZED_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDIZED_NAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. 17/18 Gene Ontology MF GO:0070403 9.75392324183546e-07 1.85444960400328e-06 330 405.272727272727 379 8.86720687848997e-08 152 2.02682545115431 -1.85549734247913 -1 12.3976791535469 295 152 437 327 473 379 639 328 661 426 341 370 M17849 GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. 15/25 Gene Ontology MF GO:0004112 7.92960026250118e-05 8.7018416182317e-05 380 473.636363636364 380 7.20898735323838e-06 197 1.88089401513679 1.85831772591636 1 8.15015843695074 380 700 430 810 834 227 222 197 743 357 310 371 M18966 GO_PROTEIN_DOMAIN_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DOMAIN_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a specific domain of a protein. 704/931 Gene Ontology MF GO:0019904 1.41995496580964e-07 8.2820001624993e-07 405 426.181818181818 380 1.41995505654189e-08 139 1.86186624707215 1.96692747782457 1 12.0842413382724 401 231 902 165 146 380 424 889 290 139 721 372 M19108 GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. 10/11 Gene Ontology MF GO:0008195 6.60646233848885e-07 1.40008513778984e-06 470 359.545454545455 380 6.00587665669908e-08 101 1.96751639657222 -1.59976511217883 -1 12.2911855298644 466 180 299 130 422 442 552 741 101 242 380 373 M19163 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. 27/82 Gene Ontology MF GO:0016709 3.24293660862136e-07 9.51261405195598e-07 450 402 382 2.94812462422768e-08 100 3.71891489910505 -4.16096637144263 -1 23.8984407912219 450 411 100 382 293 376 349 757 554 189 561 374 M18553 GO_ION_CHANNEL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_CHANNEL_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. 122/168 Gene Ontology MF GO:0044325 2.36060345566206e-07 8.86665688224285e-07 665 323.727272727273 383 2.14600337177747e-08 5 2.16293801296152 2.24349012132623 1 13.9699350755146 434 5 155 52 224 405 449 665 383 126 663 375 M18192 GO_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASE_BINDING.html Interacting selectively and non-covalently with any protease or peptidase. 121/192 Gene Ontology MF GO:0002020 1.37598029372074e-07 8.2820001624993e-07 515 398.272727272727 384 1.25089125434621e-08 113 2.32366613881881 2.76784273294912 1 15.0815042520664 515 384 136 311 113 467 665 795 380 141 474 376 M18388 GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 215/261 Gene Ontology MF GO:0005088 2.03951685886388e-07 8.48926288617081e-07 560 386.090909090909 386 1.85410640721632e-08 9 2.17139778842678 2.17397738529801 1 14.0683476363355 557 249 68 9 199 536 455 901 386 55 832 377 M18746 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 14/23 Gene Ontology MF GO:0016638 2.84435279878976e-06 4.34410245633346e-06 485 417.818181818182 387 2.58577861474999e-07 139 3.59398930187565 3.9913311984559 1 20.5658128087686 484 432 139 208 597 698 865 387 227 233 326 378 M18226 GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. 65/94 Gene Ontology MF GO:0008081 5.87250801949876e-07 1.30124638129901e-06 390 377.545454545455 388 5.33864507914611e-08 122 2.02813136051532 2.12222011068196 1 12.7386664698354 388 278 248 524 400 122 154 700 581 138 620 379 M18426 GO_COPPER_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_BINDING.html Interacting selectively and non-covalently with copper (Cu) ions. 44/68 Gene Ontology MF GO:0005507 1.23430211642546e-06 2.21455370014975e-06 575 460.363636363636 388 1.12209346266071e-07 105 3.07958010336415 3.56630001859177 1 18.5838769305721 574 284 105 388 504 796 815 329 248 355 666 380 M19182 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 37/89 Gene Ontology MF GO:0004869 2.63335575203299e-06 4.11712472906681e-06 200 367.545454545455 388 2.39396264010195e-07 52 2.30613315712651 -2.8968538598735 -1 13.2536955170088 438 400 200 380 583 452 388 200 583 367 52 381 M18959 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. 75/103 Gene Ontology MF GO:0016811 5.52246833323381e-07 1.26879706209363e-06 380 465.181818181818 390 5.02042701771947e-08 248 1.61187692103692 -1.50512627785062 -1 10.1430427273937 376 659 649 597 383 256 493 376 390 690 248 382 M17868 GO_IMMUNOGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_BINDING.html Interacting selectively and non-covalently with an immunoglobulin. 4/24 Gene Ontology MF GO:0019865 0.000171142968758781 0.000183665625009424 395 411 391 1.71156150649686e-05 128 4.07481863031613 -4.07481863031613 -1 16.2459864966393 324 526 800 394 868 391 168 128 208 509 205 383 M18237 GO_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_ACTIVITY.html The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. 44/137 Gene Ontology MF GO:0005179 3.4876700091381e-07 9.87125518052375e-07 395 443.454545454545 391 3.17060960185467e-08 66 3.67799706780352 4.11427534859749 1 23.5724097057315 391 745 66 863 303 418 277 361 656 118 680 384 M18249 GO_PHOSPHATIDYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BINDING.html Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. 13/28 Gene Ontology MF GO:0031210 2.90025032039867e-05 3.35818458151425e-05 375 395.727272727273 391 2.63662595906973e-06 25 1.80849869061012 -1.63680820316102 -1 8.63451880504881 373 512 391 409 794 204 159 239 698 549 25 385 M18994 GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. 70/84 Gene Ontology MF GO:0050660 1.32132888479136e-07 8.2820001624993e-07 200 350.636363636364 391 1.2012081492281e-08 89 1.73592175774946 -1.86751458378395 -1 11.2668120712021 197 391 502 482 99 89 163 462 660 487 325 386 M18543 GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. 90/118 Gene Ontology MF GO:1902936 2.66746501787847e-07 9.26593111473573e-07 250 476.363636363636 392 2.42496849209493e-08 25 2.16686010963793 1.95685991427289 1 13.9510325289331 910 25 250 148 248 863 823 497 376 392 708 387 M18135 GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. 30/45 Gene Ontology MF GO:0015662 6.0791200261125e-07 1.32792125393096e-06 685 369.090909090909 393 5.526474278107e-08 145 2.49869379271786 -2.69504692426174 -1 15.6707639863237 682 296 225 155 405 515 541 145 400 303 393 388 M18314 GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY.html Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. 10/11 Gene Ontology MF GO:0005092 7.15007619825241e-07 1.49225334915293e-06 860 435.818181818182 393 6.50007138368454e-08 76 1.69807627856381 -1.07001720499809 -1 10.5578028682404 857 182 357 393 429 739 567 217 76 327 650 389 M18815 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. 27/49 Gene Ontology MF GO:0016684 3.69921898786429e-07 1.02225828835946e-06 365 387.727272727273 394 3.36292691806772e-08 241 1.91830553940009 -1.69683453858211 -1 12.2633920013751 364 410 272 433 313 398 241 528 394 360 552 390 M18016 GO_ENHANCER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENHANCER_BINDING.html Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. 100/142 Gene Ontology MF GO:0035326 1.90262787284386e-06 3.13933599019237e-06 465 399.909090909091 396 1.72966319845194e-07 262 1.99914554279272 2.08080914810129 1 11.7406157790754 383 386 262 369 551 434 465 272 461 420 396 391 M18676 GO_VITAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BINDING.html Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 68/91 Gene Ontology MF GO:0019842 2.94130429498415e-07 9.30984999064807e-07 840 482.181818181818 396 2.67391335293074e-08 146 2.15621396242941 -2.04251376192007 -1 13.8777632781351 838 275 246 384 263 675 608 705 396 146 768 392 M18822 GO_GTPASE_ACTIVATING_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVATING_PROTEIN_BINDING.html Interacting selectively and non-covalently with a GTPase activating protein. 31/36 Gene Ontology MF GO:0032794 5.61346976689743e-05 6.24169201517837e-05 275 460.818181818182 396 5.10328454911548e-06 82 2.12600640475028 2.8649628615152 1 9.5396725367857 273 750 396 811 857 392 414 82 230 507 357 393 M18626 GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY.html Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. 4/8 Gene Ontology MF GO:0016175 1.26002300798068e-05 1.55858267653836e-05 365 493.636363636364 397 1.26003015249861e-06 237 1.73699654190218 2.09045360952427 1 8.91110577215972 440 361 871 529 749 395 237 394 694 363 397 394 M17877 GO_LONG_CHAIN_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 14/26 Gene Ontology MF GO:0036041 1.1099868912319e-05 1.38224782681708e-05 290 413.454545454545 398 1.00908408326702e-06 109 2.25595491252265 -2.93295518861933 -1 11.6989927679094 429 506 286 360 736 548 299 109 590 398 287 395 M18748 GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any N-glycosyl bond. 21/26 Gene Ontology MF GO:0016799 2.4936153648157e-05 2.91658303429077e-05 205 420.909090909091 398 2.26694875403188e-06 201 1.80463315150241 1.86231053716267 1 8.7339835337495 201 561 402 441 785 327 364 299 398 471 381 396 M18186 GO_PHOSPHATE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_BINDING.html Interacting selectively and non-covalently with phosphate. 14/18 Gene Ontology MF GO:0042301 0.00256870932817086 0.00265194125053618 335 509.181818181818 399 0.000233792132046523 156 1.58226161463665 -1.65870990901066 -1 4.35042452994067 205 827 574 799 892 236 156 334 844 399 335 397 M18525 GO_RETINAL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_BINDING.html Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. 11/18 Gene Ontology MF GO:0016918 4.357079957008e-05 4.93980598806796e-05 335 497.818181818182 400 3.96106022815661e-06 136 2.43977427437424 2.16329100819699 1 11.2121029318238 335 773 213 812 809 316 144 751 787 136 400 398 M19159 GO_CYTOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_ACTIVITY.html Functions to control the survival, growth, differentiation and effector function of tissues and cells. 103/239 Gene Ontology MF GO:0005125 6.24719636177578e-12 1.6977674818473e-10 615 416.727272727273 401 5.67926941981231e-13 25 3.16831928164148 -3.046570809162 -1 33.0341498627915 613 269 25 294 379 839 817 432 401 26 489 399 M18641 GO_MHC_CLASS_I_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 33/68 Gene Ontology MF GO:0042288 2.50602680410374e-06 3.95413958215845e-06 40 322.545454545455 402 2.2782087806647e-07 6 1.23650410215961 -1.14696548955343 -1 7.12952228506438 38 402 571 504 577 6 21 124 825 445 35 400 M19040 GO_ARYLSULFATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYLSULFATASE_ACTIVITY.html Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. 9/10 Gene Ontology MF GO:0004065 9.3666584032933e-08 8.2820001624993e-07 55 425.636363636364 402 9.36665879809762e-09 55 3.107194603981 4.13148791260982 1 20.1669121365291 656 198 908 134 55 563 402 733 55 274 704 401 M19229 GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY.html Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. 18/21 Gene Ontology MF GO:0030296 1.04916187609397e-05 1.31358478795505e-05 400 425.727272727273 402 9.53788072267207e-07 199 2.3784949131421 -2.12055017935428 -1 12.3906303850646 396 420 216 402 731 424 571 674 199 290 360 402 M18094 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the epidermal growth factor receptor. 40/47 Gene Ontology MF GO:0005154 4.54847943216138e-06 6.48579474585974e-06 370 417.090909090909 403 4.13498985102481e-07 280 2.21379084635107 -2.38763644798813 -1 12.2567065665274 367 475 319 280 638 403 487 584 297 427 311 403 M18711 GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. 55/83 Gene Ontology MF GO:0035004 6.0444499404069e-07 1.32347671680947e-06 735 399.818181818182 404 5.49495600100582e-08 51 2.77204672633806 -2.82225459847559 -1 17.3894270018432 735 51 106 51 404 644 429 883 119 243 733 404 M19137 GO_AMMONIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_BINDING.html Interacting selectively and non-covalently with ammonium ions (NH4+). 31/79 Gene Ontology MF GO:0070405 2.95510609271093e-07 9.30984999064807e-07 865 483.090909090909 404 2.68646044513612e-08 194 2.57655783271013 -2.0189401016324 -1 16.5831691525382 865 404 194 308 264 534 576 688 375 330 776 405 M19209 GO_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY.html Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 376/431 Gene Ontology MF GO:0016874 4.94633734272274e-07 1.21672017060695e-06 315 521.636363636364 404 4.49667132256863e-08 216 1.34056328009907 -1.35039159294263 -1 8.46178866009525 313 789 796 877 354 274 404 216 520 888 307 406 M18967 GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a sodium channel. 30/43 Gene Ontology MF GO:0017080 2.66427209655732e-06 4.13745784406549e-06 670 434.181818181818 406 2.42206847553056e-07 37 2.21766169206248 -2.47661324099046 -1 12.7401730060565 669 406 221 303 587 764 797 37 599 213 180 407 M18472 GO_ALPHA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. 28/35 Gene Ontology MF GO:0043014 5.39810908983323e-06 7.44455641642672e-06 415 438.363636363636 407 4.90738394103924e-07 311 1.8803639359041 -1.64206205762197 -1 10.2905293064638 414 480 397 407 657 348 342 691 414 311 361 408 M18234 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells. 34/39 Gene Ontology MF GO:1901505 1.58964212458398e-07 8.2820001624993e-07 410 358.363636363636 409 1.44512930858718e-08 84 1.59234133196231 -1.84919109603441 -1 10.334918640628 409 84 413 629 150 386 548 88 577 197 461 409 M17887 GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. 11/16 Gene Ontology MF GO:0004115 5.07905252721929e-05 5.68853883048561e-05 355 494.181818181818 410 4.61742708097783e-06 193 1.63397861812031 1.8691123373851 1 7.40215333132092 353 776 458 741 818 224 193 251 831 381 410 410 M19057 GO_NEUROPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_BINDING.html Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). 4/38 Gene Ontology MF GO:0042923 4.3165670388235e-05 4.9119555959026e-05 405 461.545454545455 410 4.31665088849531e-06 72 5.43956848954327 5.43956848954327 1 25.0120624252019 403 642 910 410 859 516 345 72 244 510 166 411 M18535 GO_LIGASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_REGULATOR_ACTIVITY.html Modulates the activity of a ligase. 15/20 Gene Ontology MF GO:0055103 1.03963584871451e-05 1.30871252888307e-05 240 409.909090909091 411 9.45127965153063e-07 143 1.74864351747449 -1.77413567076321 -1 9.11246717093368 237 824 411 640 727 161 143 210 485 521 150 412 M18780 GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. 26/29 Gene Ontology MF GO:0015605 2.47521890340355e-07 9.05170150212826e-07 465 346 411 2.25019925626395e-08 101 1.33614208444882 -1.47318743865761 -1 8.61705244660913 461 101 471 484 230 411 438 167 407 173 463 413 M18428 GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS.html Catalysis of the hydrolysis of any glycosyl bond. 93/134 Gene Ontology MF GO:0016798 1.68866214971363e-07 8.2829858135462e-07 515 396.909090909091 412 1.53514752666446e-08 163 1.69239134076463 -1.49844818489942 -1 10.9841892024178 513 270 412 677 163 283 484 464 431 395 274 414 M19091 GO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_BINDING.html Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. 342/380 Gene Ontology MF GO:0051020 1.1407398503387e-07 8.2820001624993e-07 380 448.545454545455 412 1.03703628135284e-08 69 1.51403226664497 -1.55786886035029 -1 9.82666200938065 377 366 677 778 69 340 551 412 456 667 241 415 M18243 GO_MANGANESE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_BINDING.html Interacting selectively and non-covalently with manganese (Mn) ions. 58/69 Gene Ontology MF GO:0030145 1.98917258006119e-07 8.48419306341761e-07 640 429.181818181818 413 1.808338872651e-08 52 1.90468453397245 -1.54820433739877 -1 12.3408564847368 638 52 351 679 194 480 659 321 378 556 413 416 M18677 GO_RAL_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAL_GTPASE_BINDING.html Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. 18/21 Gene Ontology MF GO:0017160 1.09723882246954e-06 2.02365004383603e-06 145 381.181818181818 415 9.97490336102006e-08 119 1.200923554751 -0.947062486809633 -1 7.2972056035464 235 142 583 813 487 136 119 142 514 607 415 417 M18405 GO_NUCLEOSIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. 12/14 Gene Ontology MF GO:0019206 2.79612722242157e-06 4.29887113730039e-06 570 407.363636363636 416 2.54193706928463e-07 168 1.46484162404085 -1.06985905012691 -1 8.38933802986332 568 168 440 399 593 335 320 493 200 416 549 418 M18950 GO_ACTIN_MONOMER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MONOMER_BINDING.html Interacting selectively and non-covalently with monomeric actin, also known as G-actin. 24/36 Gene Ontology MF GO:0003785 6.25369873254448e-06 8.38787897023337e-06 395 459.181818181818 416 5.68519682665345e-07 116 1.59547504349286 1.58216463902538 1 8.64321866428802 395 116 516 316 679 286 459 772 688 408 416 419 M18944 GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING.html Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 18/25 Gene Ontology MF GO:0090079 9.17382468082265e-08 8.2820001624993e-07 420 452.636363636364 417 8.33984096669441e-09 38 1.17348697372301 -0.9253288237659 -1 7.61638912888802 419 698 648 652 38 417 360 252 370 738 387 420 M18832 GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 22/25 Gene Ontology MF GO:0005086 2.26389457049265e-06 3.626772132975e-06 455 400.727272727273 418 2.05808809103712e-07 12 2.41211111568789 -2.17712368564649 -1 14.0045343376524 452 686 487 230 567 333 418 385 12 682 156 421 M18955 GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. 9/19 Gene Ontology MF GO:0015166 1.05431757439155e-07 8.2820001624993e-07 680 403.090909090909 420 1.0543176244129e-08 22 4.73998393583237 4.38908491313482 1 30.7643570425604 679 196 901 22 74 722 488 420 106 273 553 422 M18269 GO_L_ASCORBIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_BINDING.html Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 18/21 Gene Ontology MF GO:0031418 5.64367524372818e-07 1.26879706209363e-06 425 414.545454545455 422 5.13061517409511e-08 92 2.24075137803613 -1.43072767503355 -1 14.1003562105039 723 422 329 141 390 769 501 310 92 459 424 423 M18529 GO_WW_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WW_DOMAIN_BINDING.html Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. 29/34 Gene Ontology MF GO:0050699 9.99650404865305e-08 8.2820001624993e-07 280 439.727272727273 422 9.08773136625522e-09 51 2.47884790359071 3.09262249044223 1 16.0886949352185 805 300 210 480 51 759 530 422 280 276 724 424 M18889 GO_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BINDING.html Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 243/308 Gene Ontology MF GO:0048037 9.09889609888751e-08 8.2820001624993e-07 335 387.090909090909 422 8.27172406836847e-09 36 1.83712641880335 -1.99563169166189 -1 11.9236701231445 331 463 422 618 36 262 411 450 505 318 442 425 M18121 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 234/368 Gene Ontology MF GO:0001228 1.6894256690602e-07 8.2829858135462e-07 425 476.545454545455 424 1.53584163526793e-08 164 2.0817319628303 2.20187253725272 1 13.5111414853743 424 650 220 690 164 255 247 918 611 285 778 426 M18687 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. 34/37 Gene Ontology MF GO:0032266 4.19295873918391e-06 6.0740961643352e-06 230 433.181818181818 424 3.8117879368407e-07 192 1.44870630949486 1.95464604011736 1 8.06482951707002 227 478 567 424 628 357 286 506 192 767 333 427 M18430 GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. 23/28 Gene Ontology MF GO:0003950 4.0092609857606e-06 5.87093050846719e-06 195 402 425 3.64478935656528e-07 122 1.20532256139365 -1.12443672826427 -1 6.72893614372498 191 311 652 505 621 149 122 425 540 645 261 428 M18931 GO_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVITY.html Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. 20/35 Gene Ontology MF GO:0004629 2.00118598701275e-05 2.38285547938116e-05 430 429.545454545455 426 1.81927653693868e-06 224 2.20780406477214 2.38463407635546 1 10.8920439357234 426 489 227 305 771 396 258 602 582 224 445 429 M19183 GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. 45/53 Gene Ontology MF GO:0005547 8.61482566785032e-07 1.70817573328191e-06 415 407.727272727273 426 7.83166276479212e-08 64 1.95986668383695 1.96544359674103 1 12.0627363193482 412 64 342 315 453 426 513 573 292 516 579 430 M18037 GO_FMN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FMN_BINDING.html Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 11/14 Gene Ontology MF GO:0010181 0.000222256072318301 0.000237141582935462 430 444.636363636364 428 2.02071390020529e-05 88 2.6751595696708 -2.13266729669186 -1 10.3488219242835 428 709 389 485 896 325 361 138 494 578 88 431 M18864 GO_TRANSLATION_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY.html Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 32/42 Gene Ontology MF GO:0045182 4.30417051022333e-08 7.50387462537048e-07 345 473.545454545455 428 3.91288235857445e-09 2 1.28450586758105 -0.928079354496474 -1 8.39568322578834 342 752 654 707 2 349 206 366 664 739 428 432 M19036 GO_CYTOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_ACTIVITY.html Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 50/95 Gene Ontology MF GO:0004896 5.84897386393781e-07 1.30124638129901e-06 400 477.727272727273 430 5.31725038087354e-08 144 2.42950777368091 2.20287123975635 1 15.2597070173705 386 397 144 776 398 444 430 877 532 144 727 433 M17982 GO_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 159/232 Gene Ontology MF GO:0004713 7.17056804138421e-07 1.49225334915293e-06 310 416.818181818182 431 6.51870034411248e-08 135 2.31876955008136 2.59904012820593 1 14.4169692950086 309 598 135 488 431 416 375 470 475 312 576 434 M18907 GO_PDZ_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PDZ_DOMAIN_BINDING.html Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. 106/141 Gene Ontology MF GO:0030165 6.38388455368189e-08 8.2820001624993e-07 10 496.181818181818 431 5.80353158084296e-09 8 1.98785064113938 2.27962467700037 1 12.9019296028285 866 10 214 431 8 879 840 886 348 82 894 435 M18771 GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY.html Modulation of the activity of the enzyme protein phosphatase type 2A. 20/22 Gene Ontology MF GO:0008601 8.30013714443817e-06 1.06964110480626e-05 435 510.181818181818 435 7.54560769024978e-07 90 1.26015345641463 1.60118041081357 1 6.68467761278963 435 759 638 457 709 433 408 413 90 844 426 436 M18918 GO_SIGNALING_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. 68/96 Gene Ontology MF GO:0035591 1.7797919356219e-07 8.37618242795071e-07 890 501.363636363636 435 1.61799279964221e-08 172 1.67652070157412 -1.8541134750382 -1 10.8724896040507 886 276 435 237 172 902 764 617 245 413 568 437 M19154 GO_DNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with a DNA polymerase. 14/16 Gene Ontology MF GO:0070182 2.55230277078848e-05 2.97696397078025e-05 240 430.454545454545 436 2.32030216499465e-06 173 1.03723692265519 1.22688992990642 1 5.01012142574296 173 436 582 364 787 240 496 240 542 655 220 438 M18624 GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY.html Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 10/14 Gene Ontology MF GO:0004467 3.14906792903018e-07 9.47817595535048e-07 440 529.454545454545 437 2.8627894361692e-08 86 2.33525170645461 -1.75020009031147 -1 15.0106873332402 903 345 266 387 279 871 913 440 86 437 897 439 M18867 GO_NF_KAPPAB_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NF_KAPPAB_BINDING.html Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. 37/42 Gene Ontology MF GO:0051059 2.36753982425542e-06 3.75877456634366e-06 375 479.181818181818 437 2.15231124736165e-07 297 1.16634341276591 -1.08819834634439 -1 6.75237495170058 374 613 668 372 573 309 297 437 593 712 323 440 M18569 GO_MICROFILAMENT_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROFILAMENT_MOTOR_ACTIVITY.html Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 15/31 Gene Ontology MF GO:0000146 1.33753282574861e-07 8.2820001624993e-07 740 406 440 1.21593900642411e-08 8 2.6117484045476 -2.479230364552 -1 16.9512714534504 736 146 218 97 102 651 775 580 8 440 713 441 M19220 GO_COENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BINDING.html Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 172/214 Gene Ontology MF GO:0050662 7.96842964844503e-08 8.2820001624993e-07 335 432.818181818182 440 7.24402721551147e-09 22 1.63239347148267 -1.75079474461925 -1 10.5948727777942 334 530 626 689 22 257 421 347 618 477 440 442 M18414 GO_STEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 14/25 Gene Ontology MF GO:0015248 4.2135068982696e-07 1.11129935559625e-06 775 450.363636363636 441 3.83046155023042e-08 119 2.6168036945196 -1.60882706858975 -1 16.627481643275 774 441 277 362 329 518 370 119 678 491 595 443 M18423 GO_14_3_3_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_14_3_3_PROTEIN_BINDING.html Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. 38/67 Gene Ontology MF GO:0071889 5.63857838969922e-07 1.26879706209363e-06 320 446.363636363636 442 5.12598166805622e-08 316 1.52177342281804 1.79196133388641 1 9.57604913366694 442 401 515 541 389 410 316 549 318 489 540 444 M18752 GO_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any chemokine receptor. 36/77 Gene Ontology MF GO:0042379 6.24188574641047e-06 8.38787897023337e-06 310 450.545454545455 443 5.67445768735349e-07 190 2.66071387007405 -2.49478053704575 -1 14.413973380471 307 476 190 310 678 355 443 765 647 235 550 445 M18331 GO_MACROLIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROLIDE_BINDING.html Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. 16/18 Gene Ontology MF GO:0005527 7.45899109124611e-07 1.5315795040692e-06 445 474.636363636364 445 6.78090329107392e-08 271 1.76684990214776 1.94883415786233 1 10.9641027146277 445 324 373 478 434 705 880 531 271 299 481 446 M18579 GO_CHAPERONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_BINDING.html Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. 103/131 Gene Ontology MF GO:0051087 7.87314976010258e-07 1.58838217867572e-06 410 467.636363636364 445 7.1574114342469e-08 249 1.63521406962709 -1.38719889581701 -1 10.1196437976283 407 601 539 598 445 275 417 304 614 695 249 447 M17863 GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate from one side of the membrane to the other. 31/38 Gene Ontology MF GO:1901677 1.65408230042734e-07 8.2829858135462e-07 875 437 446 1.50371129526405e-08 82 1.48749539188623 -1.56228542893206 -1 9.65434521377919 871 82 371 189 158 723 637 474 446 95 761 448 M18712 GO_FK506_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FK506_BINDING.html Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. 16/18 Gene Ontology MF GO:0005528 7.45899109124611e-07 1.5315795040692e-06 450 474.545454545455 446 6.78090329107392e-08 272 1.76684990214776 1.94883415786233 1 10.9641027146277 446 325 374 479 435 706 881 520 272 300 482 449 M19184 GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. 75/108 Gene Ontology MF GO:0000980 4.94183289129402e-06 6.95015767360072e-06 490 448.545454545455 446 4.49258544737024e-07 204 2.04950222495046 2.04502290758338 1 11.2814345122984 489 390 285 288 646 626 695 204 374 446 491 450 M17965 GO_TAU_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_BINDING.html Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. 16/20 Gene Ontology MF GO:0048156 1.23700670853114e-06 2.21510503620693e-06 455 392.909090909091 447 1.12455218551872e-07 50 2.15568868044591 2.85820579417703 1 13.0083593445973 356 634 455 451 505 305 128 447 50 699 292 451 M18392 GO_ENZYME_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of an enzyme. 462/550 Gene Ontology MF GO:0008047 1.33960406089894e-07 8.2820001624993e-07 640 480.454545454545 447 1.217821947699e-08 103 1.83247492985656 -1.73017467653398 -1 11.8934801305453 639 364 410 464 103 581 767 719 415 376 447 452 M18730 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. 22/30 Gene Ontology MF GO:0016628 9.51174994049676e-07 1.8348344352858e-06 685 485.727272727273 447 8.64704913902356e-08 216 1.60900776624963 -1.7460202136064 -1 9.84990252099606 216 684 447 701 464 270 321 383 790 681 386 453 M18025 GO_RACEMASE_AND_EPIMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RACEMASE_AND_EPIMERASE_ACTIVITY.html Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. 16/18 Gene Ontology MF GO:0016854 2.89132097370263e-07 9.30984999064807e-07 265 505.636363636364 448 2.62847395790068e-08 262 1.60383340174236 1.87380122410433 1 10.3225464201117 749 326 448 727 262 753 553 264 438 384 658 454 M17999 GO_ACID_AMINO_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_AMINO_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 21/27 Gene Ontology MF GO:0016881 9.2929442753177e-08 8.2820001624993e-07 370 484.363636363636 449 8.44813151623434e-09 40 1.41001813231041 -1.25686303974674 -1 9.15156937093895 370 813 531 888 40 267 235 449 690 612 433 455 M18871 GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. 9/12 Gene Ontology MF GO:0010857 4.53887553730764e-06 6.48579474585974e-06 350 437.454545454545 449 4.53888480796029e-07 85 2.09725838044345 2.02805687316681 1 11.6115216009894 348 578 891 449 647 214 85 516 122 618 344 456 M18474 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. 10/10 Gene Ontology MF GO:0016723 8.14721794641032e-07 1.62944358928206e-06 290 451.363636363636 450 7.40656451232322e-08 153 1.48944591680327 -1.59094974285395 -1 9.19992802656363 288 713 478 692 450 320 403 153 641 639 188 457 M18993 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the tumor necrosis factor receptor. 25/34 Gene Ontology MF GO:0005164 1.54715992631127e-06 2.6673977541804e-06 165 413.090909090909 450 1.40651001305412e-07 129 1.80853926224119 -1.60967268973756 -1 10.7577687886995 165 481 450 589 525 223 413 129 777 496 296 458 M19103 GO_EXTRACELLULAR_GLUTAMATE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_GLUTAMATE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. 9/22 Gene Ontology MF GO:0005234 3.11009085667533e-06 4.72651965718421e-06 460 438.363636363636 450 3.11009520938321e-07 120 2.52792640980087 2.59076526299598 1 14.36665301445 458 450 914 239 609 328 419 638 188 120 459 459 M17955 GO_DNA_SECONDARY_STRUCTURE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SECONDARY_STRUCTURE_BINDING.html Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. 23/27 Gene Ontology MF GO:0000217 3.13550781042432e-06 4.75732219512655e-06 35 339.909090909091 451 2.85046570841419e-07 23 1.32683532498515 1.41435624162393 1 7.53664397655961 35 623 562 648 600 23 28 54 628 451 87 460 M18310 GO_TOXIC_SUBSTANCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIC_SUBSTANCE_BINDING.html Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems. 10/17 Gene Ontology MF GO:0015643 2.41440341858522e-05 2.83110248575221e-05 555 516.090909090909 451 2.19493628728174e-06 240 2.19603253560003 -2.10299765076342 -1 10.6585372018228 555 451 291 397 783 499 369 922 894 240 276 461 M18232 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 72/118 Gene Ontology MF GO:0003705 8.54606044359506e-07 1.69818491395308e-06 340 462.363636363636 452 7.76914887579671e-08 339 1.79343756616717 1.98401636781308 1 11.043261311867 339 541 378 637 452 421 416 382 535 508 477 462 M18866 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. 11/23 Gene Ontology MF GO:0016863 9.87275518339377e-08 8.2820001624993e-07 245 467.818181818182 452 8.97523238767737e-09 47 1.03956563574296 -1.10005106823756 -1 6.74718697690167 244 577 613 705 47 290 396 452 854 583 385 463 M18528 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the transforming growth factor beta receptor. 37/59 Gene Ontology MF GO:0005160 2.01842400010904e-07 8.48926288617081e-07 265 475 453 1.83493107753863e-08 197 2.18489983992726 2.36042082068873 1 14.155826583608 501 551 264 347 197 541 885 858 262 366 453 464 M17898 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 55/65 Gene Ontology MF GO:0016627 8.7038064300963e-07 1.71477977428763e-06 100 487.090909090909 455 7.91255443051269e-08 100 1.22317146504456 -1.30435609989828 -1 7.52628008266816 100 738 681 709 455 154 242 345 782 854 298 465 M18599 GO_CGMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BINDING.html Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). 7/19 Gene Ontology MF GO:0030553 0.00174953316917322 0.00181841242780209 215 487.454545454545 456 0.000175091208715107 129 4.14234359789446 4.14234359789446 1 12.1137773984047 214 781 870 646 888 281 129 287 277 533 456 466 M18065 GO_PEPTIDE_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for peptide hormones. 18/24 Gene Ontology MF GO:0051428 6.4171767998488e-07 1.37256281552322e-06 500 415.272727272727 457 5.83379879243176e-08 167 2.47594392060669 3.25173341669877 1 15.490143698055 558 499 274 196 416 552 590 496 363 457 167 467 M18174 GO_THIOLESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOLESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. 33/40 Gene Ontology MF GO:0016790 1.64398039583845e-06 2.78212066988046e-06 100 373.363636363636 457 1.494528749388e-07 67 1.94873449737254 -1.91415855459876 -1 11.5536622893537 99 616 457 696 533 114 67 184 473 622 246 468 M18266 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a protein serine/threonine kinase. 23/25 Gene Ontology MF GO:0043539 2.46125801261161e-06 3.89418219803617e-06 335 488.909090909091 457 2.23750978741572e-07 232 2.01582891117461 -2.30011743703119 -1 11.6372848631693 457 889 454 331 576 483 232 289 737 596 334 469 M19149 GO_MONOCARBOXYLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BINDING.html Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). 45/99 Gene Ontology MF GO:0033293 1.48524365742644e-07 8.2820001624993e-07 615 424.272727272727 457 1.35022159790623e-08 131 2.28224728637252 -2.3514450314 -1 14.8126796105108 612 285 177 444 131 620 550 507 625 259 457 470 M17872 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. 25/30 Gene Ontology MF GO:0035255 5.80112409524207e-06 7.9293471361001e-06 520 442.272727272727 459 5.27376308375932e-07 111 1.54983051335847 -1.22891693831254 -1 8.43632735974514 517 111 459 197 665 471 687 297 722 433 306 471 M18420 GO_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. 51/149 Gene Ontology MF GO:0004497 9.7508013565082e-08 8.2820001624993e-07 910 463 459 8.86436526243777e-09 45 3.2508662762959 -3.34455191252419 -1 21.0993977929537 909 395 53 377 45 699 731 637 459 77 711 472 M18007 GO_NEUROPEPTIDE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neuropeptide receptor. 13/31 Gene Ontology MF GO:0071855 3.02683337430587e-05 3.49599254732328e-05 245 480.545454545455 461 2.75170456299191e-06 140 2.75637052286932 2.99277109453078 1 13.1086750416305 242 705 233 683 796 179 140 900 707 461 240 473 M18564 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). 16/21 Gene Ontology MF GO:0016755 1.92115246813518e-06 3.15591367892489e-06 160 417.090909090909 461 1.74650376889616e-07 75 1.4065901845659 -1.6189861054084 -1 8.25721237113326 157 502 461 695 553 78 75 270 873 633 291 474 M17962 GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. 10/15 Gene Ontology MF GO:0034483 6.01047745107552e-06 8.15518526401436e-06 465 392.636363636364 462 5.46408533815847e-07 31 3.28823512723085 4.43843518928087 1 17.8563411979454 462 640 244 339 671 529 588 40 31 542 233 475 M18187 GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. 13/18 Gene Ontology MF GO:0004550 4.34216061285553e-06 6.25921436236896e-06 545 484.272727272727 462 3.94742653003845e-07 140 1.81657970731286 2.1594702533198 1 10.0874755404465 542 174 386 440 632 703 810 433 140 462 605 476 M19179 GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_.html Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. 13/15 Gene Ontology MF GO:0031078 2.75479524165743e-06 4.24946711734802e-06 570 455.909090909091 462 2.50436244651094e-07 62 1.12326367969658 -1.18537233914976 -1 6.43909365873589 570 173 608 62 591 462 558 414 425 708 444 477 M19187 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 23/26 Gene Ontology MF GO:0016645 5.28014949140512e-07 1.23203488132786e-06 340 499.909090909091 463 4.800137053343e-08 312 1.6474011140081 1.56316997597924 1 10.3890344908891 337 312 381 625 375 650 877 443 463 514 522 478 M17851 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. 22/27 Gene Ontology MF GO:0016814 4.13932591436539e-06 6.01373764917235e-06 415 429.909090909091 466 3.76303063870578e-07 101 2.18718800799949 1.96147350795828 1 12.1860216156196 413 485 280 466 627 476 811 101 136 351 583 479 M19041 GO_NOTCH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_BINDING.html Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. 23/30 Gene Ontology MF GO:0005112 8.84037895907917e-06 1.12980776738439e-05 795 528.818181818182 466 8.036740439138e-07 196 2.48752280297347 -1.40236958795175 -1 13.1323588410597 792 557 251 432 716 670 466 373 196 454 910 480 M17892 GO_PROTEIN_COMPLEX_SCAFFOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SCAFFOLD.html Functions to provide a physical support for the assembly of a multiprotein complex. 74/90 Gene Ontology MF GO:0032947 3.71063468051937e-07 1.02225828835946e-06 805 481.909090909091 468 3.37330482397682e-08 175 1.94035787224477 -1.51865621661716 -1 12.4043687432267 801 468 355 238 314 830 837 248 175 472 563 481 M18869 GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY.html Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. 8/14 Gene Ontology MF GO:0045125 1.57346713852429e-05 1.90548314023125e-05 355 549.727272727273 468 1.57347827973007e-06 207 2.36891750007387 2.62713338861073 1 11.9323398871379 352 207 889 682 763 300 442 269 808 468 867 482 M18574 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 270/414 Gene Ontology MF GO:0000982 2.76750926475699e-07 9.30984999064807e-07 255 512.545454545455 469 2.51591782990755e-08 254 2.05192004609727 2.28249521276611 1 13.2065095883381 469 593 255 783 254 378 344 848 636 391 687 483 M18978 GO_FATTY_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. 11/20 Gene Ontology MF GO:0015645 4.60987163176359e-07 1.17136440955838e-06 345 489.909090909091 469 4.19079327064965e-08 87 2.17642732723504 -1.58132653094488 -1 13.7761800361717 760 342 278 469 342 763 675 380 87 480 813 484 M19165 GO_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_ACTIVITY.html Catalysis of the hydrolysis of a glycerophospholipid. 69/102 Gene Ontology MF GO:0004620 5.02540909307347e-07 1.21909632942585e-06 635 458.909090909091 469 4.56855476456037e-08 37 2.29619042666097 -2.13220423972054 -1 14.4917421803953 631 37 148 724 359 633 886 786 469 163 212 485 M17897 GO_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. 98/152 Gene Ontology MF GO:0016597 9.69910815746096e-07 1.84854077904815e-06 575 473.454545454545 470 8.81737493954125e-08 145 2.50248286454414 2.22341481396185 1 15.3108809199384 573 387 145 231 470 475 729 833 381 319 665 486 M18865 GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. 42/52 Gene Ontology MF GO:0008375 3.55475808586566e-07 9.98357590072909e-07 770 552.636363636364 470 3.23159878203936e-08 234 1.83800688351561 1.76829603109971 1 11.7702097539753 767 287 335 463 305 868 920 830 234 470 600 487 M19082 GO_MONOSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 60/85 Gene Ontology MF GO:0048029 8.99013182185016e-08 8.2820001624993e-07 285 401.545454545455 470 8.17284744475005e-09 33 1.60665415622196 -1.35969941735143 -1 10.4278144990112 284 470 552 481 33 135 107 594 734 626 401 488 M18313 GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. 9/21 Gene Ontology MF GO:0004303 8.8449438084147e-07 1.72784948815543e-06 490 477.363636363636 472 8.84494732890305e-08 236 0.798727235834762 -0.893319874117613 -1 4.91182618497449 488 347 843 585 472 358 334 236 531 704 353 489 M18521 GO_PALMITOYL_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYL_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. 11/16 Gene Ontology MF GO:0016290 2.11216838361918e-06 3.42995357902306e-06 585 489 472 1.92015491951383e-07 162 2.16754389743009 -1.2390042927166 -1 12.6406474182158 418 639 409 582 559 427 162 694 472 581 436 490 M18708 GO_PEPTIDE_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_BINDING.html Interacting selectively and non-covalently with any peptide with hormonal activity in animals. 25/55 Gene Ontology MF GO:0017046 9.75061063601128e-08 8.2820001624993e-07 615 454.909090909091 472 8.86419188015243e-09 44 2.17848051413746 2.56857109240132 1 14.1391924493773 614 622 242 240 44 578 714 398 705 375 472 491 M18755 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. 110/216 Gene Ontology MF GO:0016705 1.41032572844756e-07 8.2820001624993e-07 475 398.636363636364 474 1.28211438077955e-08 111 2.54668098819903 2.40968580760866 1 16.5289583316775 474 534 111 523 120 598 681 296 488 186 374 492 M18620 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. 48/54 Gene Ontology MF GO:0004520 7.16558810864945e-07 1.49225334915293e-06 355 478.818181818182 475 6.51417312958531e-08 238 1.28571443520491 1.3524894521395 1 7.99393911363552 351 546 597 647 430 287 238 451 673 572 475 493 M18927 GO_RETINOL_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. 13/32 Gene Ontology MF GO:0004745 9.87917532391967e-07 1.86792644146844e-06 595 516.818181818182 475 8.98107250927269e-08 189 2.63593638741148 -3.30362659147433 -1 16.1146416220065 593 443 189 317 475 756 692 677 771 374 398 494 M17993 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 24/39 Gene Ontology MF GO:0001205 6.07836503897835e-06 8.22314684628989e-06 345 489.818181818182 477 5.52580166628795e-07 307 1.55627354476248 2.00643628678295 1 8.44515745198885 343 483 432 644 673 415 307 477 663 546 405 495 M18975 GO_DOUBLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with double-stranded RNA. 109/150 Gene Ontology MF GO:0003725 4.69484939263926e-07 1.1885043393969e-06 495 513 479 4.26804581320997e-08 286 1.80766242327903 1.5372754130987 1 11.4298300965399 493 654 479 445 345 446 382 709 286 600 804 496 M19195 GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 30/30 Gene Ontology MF GO:0017112 9.59042488524326e-08 8.2820001624993e-07 465 465.545454545455 479 8.71856845756105e-09 42 1.33632790896172 -1.29803064094831 -1 8.67329084056328 463 93 546 395 42 663 851 626 479 555 408 497 M17986 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 18/29 Gene Ontology MF GO:0016894 1.2312065014645e-07 8.2820001624993e-07 465 476.909090909091 480 1.11927870033423e-08 83 1.48853278685627 1.38556787058481 1 9.66116035713335 636 322 480 688 83 465 461 209 523 604 775 498 M18197 GO_PHOSPHATASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVATOR_ACTIVITY.html Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 11/11 Gene Ontology MF GO:0019211 1.05665769310599e-06 1.96845102506036e-06 510 457.181818181818 480 9.60598364198106e-08 114 2.06128793203874 2.54453214949176 1 12.5514846485877 510 449 395 251 480 540 547 444 114 579 720 499 M18245 GO_SCAVENGER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAVENGER_RECEPTOR_ACTIVITY.html Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). 32/49 Gene Ontology MF GO:0005044 8.16780678754654e-07 1.63003314723391e-06 585 399.090909090909 480 7.42528165450934e-08 51 4.00731261230712 3.75966994528998 1 24.751482173348 584 291 51 117 514 554 480 569 223 127 880 500 M18131 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol phosphate. 140/175 Gene Ontology MF GO:1901981 1.93765251477269e-07 8.40700906161521e-07 865 509 481 1.76150244130152e-08 154 1.90454777192958 -1.90119333684413 -1 12.3480373394256 862 266 399 154 189 789 863 537 408 481 651 501 M18294 GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription. 30/36 Gene Ontology MF GO:0001103 9.36155717280085e-06 1.19147091290193e-05 510 512.636363636364 481 8.51054273530441e-07 198 1.52696679549228 1.80692472272675 1 8.02369438093407 508 753 640 198 720 399 415 481 449 621 455 502 M18469 GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). 7/12 Gene Ontology MF GO:0008556 5.2927944947313e-06 7.35419866636349e-06 675 449.727272727273 481 5.29280710092666e-07 57 3.01537976078611 2.02541439806629 1 16.5191147563268 674 208 861 109 666 481 475 57 502 280 634 503 M18888 GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. 25/27 Gene Ontology MF GO:0003887 4.44681516889129e-06 6.39013563927768e-06 460 502.545454545455 481 4.04256741561237e-07 311 1.14712608884775 1.15490745480005 1 6.35898975653489 459 415 584 580 634 352 481 311 667 679 366 504 M18678 GO_CHEMOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_ACTIVITY.html The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 23/62 Gene Ontology MF GO:0008009 5.87973792110358e-06 8.01309415796417e-06 415 470.909090909091 482 5.3452305776344e-07 112 3.35131330284429 -3.18476828797823 -1 18.2261801911315 411 482 112 298 669 443 544 819 613 157 632 505 M17932 GO_NARROW_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NARROW_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. 8/17 Gene Ontology MF GO:0022842 3.49339874895159e-07 9.87125518052375e-07 800 508.818181818182 484 3.49339929812427e-08 53 3.25400415096965 -3.00839351267551 -1 20.8550241920125 799 348 806 271 319 717 680 484 53 336 784 506 M18500 GO_MAP_KINASE_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_KINASE_ACTIVITY.html Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. 22/25 Gene Ontology MF GO:0004709 2.50041729867066e-05 2.92084144623476e-05 425 517.727272727273 484 2.27313247063511e-06 281 1.80664789668281 -2.2923345335334 -1 8.7425127564001 497 484 423 324 786 737 879 423 294 567 281 507 M18688 GO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 154/190 Gene Ontology MF GO:0016829 7.12228097538462e-08 8.2820001624993e-07 505 440.363636363636 484 6.47480109632852e-09 14 1.74413072944198 -1.54074372230247 -1 11.3200915259056 502 382 425 676 14 484 517 405 578 313 548 508 M18870 GO_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY.html A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. 6/11 Gene Ontology MF GO:0015279 2.0255524718793e-05 2.4087651016943e-05 655 465.636363636364 484 2.02557093499883e-06 11 2.79588879134408 -4.02343501798515 -1 13.7793051069853 653 460 890 274 776 585 384 68 11 484 537 509 M18614 GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Increases the activity of a peptidase that is involved in the apoptotic process. 22/28 Gene Ontology MF GO:0016505 2.06465872879162e-05 2.44896619435617e-05 485 526 485 1.87698009589187e-06 167 1.69508787474813 -1.55266785398048 -1 8.34109498631558 485 891 551 450 773 473 686 202 167 746 362 510 M18622 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. 16/17 Gene Ontology MF GO:0016646 1.08476862874198e-06 2.00465242591518e-06 745 497.727272727273 485 9.86153785105848e-08 145 1.87537024535485 1.66172568527551 1 11.403564760966 432 328 360 527 485 744 741 636 145 475 602 511 M18247 GO_ICOSANOID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_RECEPTOR_ACTIVITY.html Combining with an icosanoid to initiate a change in cell activity. 7/14 Gene Ontology MF GO:0004953 2.27284478512009e-07 8.67813463409488e-07 700 444.363636363636 491 2.27284501758217e-08 31 2.98361328584446 3.71150937213231 1 19.3002132072963 696 205 838 31 236 491 515 745 51 185 895 512 M18637 GO_ISOPRENOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BINDING.html Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 23/53 Gene Ontology MF GO:0019840 2.18424633246973e-07 8.64228135305932e-07 705 531.272727272727 491 1.98567868120937e-08 195 2.51102316526899 3.05570883171202 1 16.2479690372743 704 418 198 486 213 854 888 727 491 195 670 513 M19206 GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS.html Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. 12/13 Gene Ontology MF GO:0016801 1.05987763291949e-06 1.97047672599116e-06 340 506.636363636364 492 9.63525585026539e-08 338 2.56875136468213 -3.47590349638555 -1 15.6402801175028 645 636 338 492 481 596 568 476 585 418 338 514 M18487 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. 57/74 Gene Ontology MF GO:0098811 2.13150323548878e-07 8.48926288617081e-07 675 454.454545454545 493 1.93773040182065e-08 47 2.0747169524619 2.2316727899074 1 13.4419585464006 672 47 297 60 211 576 612 689 493 449 893 515 M17865 GO_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. 435/804 Gene Ontology MF GO:0008233 1.05975371671607e-07 8.2820001624993e-07 495 471.636363636364 494 9.63412516150065e-09 60 2.25766360653721 -2.11015153609065 -1 14.6531218601262 494 592 150 722 60 511 655 806 295 434 469 516 M18518 GO_CHANNEL_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_INHIBITOR_ACTIVITY.html Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 37/62 Gene Ontology MF GO:0016248 1.15600114550222e-06 2.11095861352579e-06 715 531.363636363636 494 1.0509106844812e-07 78 1.54891682201666 -1.25195068536999 -1 9.38140530465204 715 78 488 323 494 736 790 466 552 365 838 517 M18580 GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 87/102 Gene Ontology MF GO:0004725 1.56830990005259e-07 8.2820001624993e-07 820 440.272727272727 494 1.42573637441129e-08 23 2.05940109598999 -1.80119734513907 -1 13.3663201941249 820 23 236 175 147 660 850 494 575 309 554 518 M19071 GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 316/384 Gene Ontology MF GO:0003713 4.22731679588748e-07 1.11129935559625e-06 360 565.363636363636 494 3.84301600742714e-08 330 1.57508754750723 1.62972954072693 1 10.0082923225744 358 721 739 547 330 375 422 907 444 882 494 519 M18593 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 87/117 Gene Ontology MF GO:0001191 2.00064360623182e-07 8.48419306341761e-07 350 482 495 1.81876708015187e-08 195 1.84120386928201 1.81958437352657 1 11.9295516525014 347 604 495 423 195 209 332 825 632 660 580 520 M18936 GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. 23/27 Gene Ontology MF GO:0043325 1.17514954096255e-06 2.13747672411298e-06 885 541.090909090909 496 1.06831833516325e-07 242 1.88331271594341 1.66351586458 1 11.3958623899214 884 313 376 242 496 658 425 491 595 598 874 521 M19067 GO_TAU_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. 16/26 Gene Ontology MF GO:0050321 1.56894938118667e-06 2.69288126122974e-06 830 477.090909090909 496 1.4263186364526e-07 150 1.52997941029859 -0.867334168164901 -1 9.0940631224514 826 150 496 287 526 734 451 271 197 558 752 522 M18633 GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. 20/21 Gene Ontology MF GO:0052745 1.89364109912253e-06 3.13009727296819e-06 500 450.090909090909 498 1.72149339006219e-07 81 0.974066803635435 -1.25495993834151 -1 5.72184507356723 499 317 591 498 549 364 546 410 447 649 81 523 M18681 GO_GLUTATHIONE_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_TRANSFERASE_ACTIVITY.html Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. 23/38 Gene Ontology MF GO:0004364 1.27713829391412e-07 8.2820001624993e-07 555 473.272727272727 498 1.1610348800493e-08 93 1.88222393360351 -2.16407082635738 -1 12.2163707301186 551 558 361 626 93 604 446 381 783 305 498 524 M19207 GO_ACYL_COA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. 17/19 Gene Ontology MF GO:0003995 8.15459651489237e-06 1.0567808106256e-05 140 439.545454545455 498 7.41329703741843e-07 137 0.905546869410208 -0.969294138912655 -1 4.80868821511473 287 498 664 591 705 139 221 140 635 818 137 525 M18820 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. 35/45 Gene Ontology MF GO:0015932 3.03619400227155e-07 9.33885678861258e-07 780 535.090909090909 499 2.76017674663016e-08 135 1.4147613202055 -1.83538701971497 -1 9.1036060120684 776 292 499 681 272 857 872 135 686 378 438 526 M18836 GO_CARBONATE_DEHYDRATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBONATE_DEHYDRATASE_ACTIVITY.html Catalysis of the reaction: H2CO3 = CO2 + H2O. 8/14 Gene Ontology MF GO:0004089 1.12595543096486e-06 2.06425162343558e-06 785 534.272727272727 500 1.1259560014643e-07 162 2.6755703334518 -2.33711211783508 -1 16.2330135748923 785 454 886 623 506 449 318 500 427 162 767 527 M18859 GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. 12/39 Gene Ontology MF GO:0005251 1.3213207271596e-05 1.62138160942293e-05 675 451 501 1.20120787552998e-06 103 4.17926224530649 -3.77961726714969 -1 21.3638607270494 671 337 103 270 746 654 543 501 263 171 702 528 M17921 GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a sulfur compound from one side of the membrane to the other. 17/29 Gene Ontology MF GO:1901682 3.77516026471171e-06 5.563394074312e-06 465 516.545454545455 503 3.43196976621282e-07 255 1.82388129406725 -1.88733759461538 -1 10.2276377603967 464 503 407 703 617 493 582 305 789 255 564 529 M18291 GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS.html Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 30/40 Gene Ontology MF GO:0016877 5.10757440377818e-07 1.22389859342437e-06 505 471.272727272727 503 4.6432505359688e-08 143 1.79557808772099 -1.69146631283256 -1 11.3289997570107 503 554 472 400 363 571 570 430 143 620 558 530 M17983 GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. 8/28 Gene Ontology MF GO:0022835 7.39207495569119e-07 1.5280262324516e-06 760 506.727272727273 504 7.39207741461709e-08 159 2.4679176711182 2.61135012262914 1 15.3172031099815 757 353 809 313 449 504 678 857 182 159 513 531 M18725 GO_CCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a CCR chemokine receptor. 17/50 Gene Ontology MF GO:0048020 6.25583990580456e-06 8.38787897023337e-06 410 541 504 5.68714335886725e-07 329 2.0675937758614 -1.81434760347816 -1 11.2008436150778 410 504 385 329 680 455 560 726 793 424 685 532 M18277 GO_GAMMA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. 35/46 Gene Ontology MF GO:0043015 6.18695965172188e-06 8.33706368537182e-06 675 456.545454545455 505 5.62452459190437e-07 116 1.57113055336874 1.91226133541679 1 8.51576120779652 274 675 505 653 675 252 116 315 610 541 406 533 M18271 GO_DIPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a dipeptide. 10/14 Gene Ontology MF GO:0016805 0.000391754648023505 0.000412749480927843 395 511.454545454545 506 3.56204022986411e-05 168 2.01955428992635 -1.65551585003094 -1 7.29390662651263 392 641 352 586 873 535 428 168 506 722 423 534 M17924 GO_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. 177/237 Gene Ontology MF GO:0042393 1.0800995132188e-06 2.000023948325e-06 270 555.636363636364 507 9.81909130453357e-08 264 1.3743725078658 1.17370411130321 1 8.35861921084982 266 790 765 857 484 264 371 317 644 847 507 535 M18148 GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. 12/17 Gene Ontology MF GO:0017110 3.03438886268951e-05 3.50034370677291e-05 225 469.636363636364 507 2.75857337803827e-06 222 1.38146755764615 -1.46051677616948 -1 6.56914957750218 222 517 507 569 797 338 276 342 538 504 556 536 M18891 GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. 36/52 Gene Ontology MF GO:0001102 1.24342475164188e-06 2.22229104548762e-06 305 539.363636363636 507 1.13038677674317e-07 303 1.69596995903816 -1.35663564032917 -1 10.2316710095381 303 804 588 713 507 369 333 467 763 703 383 537 M19038 GO_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. 282/602 Gene Ontology MF GO:0004175 7.95099511234702e-08 8.2820001624993e-07 510 419 507 7.22817763609371e-09 20 2.61610802921013 -2.56266214302794 -1 16.9795671320606 507 529 60 614 20 558 617 885 259 148 412 538 M18163 GO_METALLOEXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOEXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 35/53 Gene Ontology MF GO:0008235 4.20502008710353e-07 1.11129935559625e-06 550 492.454545454545 508 3.82274626439985e-08 177 2.55911641628608 -1.56076424079288 -1 16.2609297595217 549 614 310 730 328 601 463 508 177 687 450 539 M19079 GO_SODIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_BINDING.html Interacting selectively and non-covalently with sodium ions (Na+). 12/30 Gene Ontology MF GO:0031402 8.09186367803987e-06 1.05012388181304e-05 125 435.363636363636 508 7.35626676457962e-07 56 3.61864326250591 -3.14212459310464 -1 19.226538687674 550 439 122 56 704 742 718 657 121 172 508 540 M18733 GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING.html Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. 44/54 Gene Ontology MF GO:0043548 3.52063818974717e-07 9.91789538819019e-07 660 483.090909090909 509 3.20058068468321e-08 156 1.76713264839705 1.82866943878261 1 11.3217518725002 660 286 390 156 304 612 562 811 627 397 509 541 M17890 GO_PROTEIN_KINASE_C_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_BINDING.html Interacting selectively and non-covalently with protein kinase C. 61/75 Gene Ontology MF GO:0005080 2.3066783017296e-06 3.67477715654854e-06 185 452.090909090909 510 2.096982472966e-07 185 1.73177426493509 1.8367021292605 1 10.0439953238849 185 737 510 599 571 186 292 353 715 560 265 542 M18716 GO_PROTEIN_KINASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVITY.html Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. 14/16 Gene Ontology MF GO:0004697 7.76687036245225e-05 8.53339859085122e-05 860 563.636363636364 510 7.06104052477872e-06 180 1.78747767100932 -1.51844521262457 -1 7.76156655004404 856 633 463 448 833 908 510 434 180 400 535 543 M18717 GO_AU_RICH_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AU_RICH_ELEMENT_BINDING.html Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. 23/26 Gene Ontology MF GO:0017091 4.89337310169983e-05 5.50057998293265e-05 90 445.363636363636 512 4.44861995132208e-06 15 1.51789207138765 1.59894138295913 1 6.89990198245816 87 810 530 785 816 34 15 489 666 512 155 544 M18644 GO_GABA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. 13/25 Gene Ontology MF GO:0050811 4.38610979942072e-07 1.13925835267672e-06 525 452.818181818182 514 3.98737333988515e-08 104 1.76544000094572 -1.14977592726414 -1 11.197483799719 567 514 419 630 336 525 661 525 104 464 236 545 M18824 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. 63/69 Gene Ontology MF GO:0030374 1.59117236033777e-07 8.2820001624993e-07 515 514.636363636364 514 1.44652043220086e-08 151 1.35816556345734 1.60228443012482 1 8.81502580653831 444 542 645 511 151 514 563 598 403 780 510 546 M18642 GO_ORGANIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BINDING.html Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage. 172/287 Gene Ontology MF GO:0043177 2.05383091197315e-07 8.48926288617081e-07 850 507.181818181818 515 1.86711918519138e-08 80 2.38963502122139 -2.38451117663542 -1 15.4822930193664 849 379 80 133 201 852 684 804 515 165 917 547 M19177 GO_STRUCTURAL_MOLECULE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_MOLECULE_ACTIVITY.html The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. 611/949 Gene Ontology MF GO:0005198 1.31575422631988e-07 8.2820001624993e-07 330 487.272727272727 515 1.3157543042243e-08 126 2.43148375920224 2.65075879526659 1 15.7812830107977 330 645 921 520 126 560 605 498 343 297 515 548 M19188 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING.html Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. 45/57 Gene Ontology MF GO:0032813 2.30527797219677e-07 8.729823140614e-07 330 472.636363636364 517 2.09570746705108e-08 222 1.70733350155413 -1.79197043769287 -1 11.0395931143545 305 547 532 642 222 432 591 330 751 517 330 549 M18689 GO_CHOLESTEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 10/18 Gene Ontology MF GO:0017127 9.70283850474408e-07 1.84854077904815e-06 815 507.909090909091 518 8.82076616733482e-08 91 3.48417055611589 4.41192178775418 1 21.3171183036013 814 518 212 195 471 887 747 91 674 329 649 550 M18728 GO_METALLOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 131/200 Gene Ontology MF GO:0008237 3.04220334780561e-07 9.33885678861258e-07 580 463.818181818182 518 2.76563978953415e-08 117 2.52379185919181 3.39585086393951 1 16.2399194568613 576 531 117 559 274 757 754 401 329 286 518 551 M18362 GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. 19/29 Gene Ontology MF GO:0008106 3.83211512772185e-07 1.04502753074643e-06 520 499 519 3.48374163202441e-08 138 1.93982135211539 -2.58705011127411 -1 12.3811338143697 519 138 288 685 317 519 620 630 762 562 449 552 M18393 GO_SH2_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH2_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. 34/52 Gene Ontology MF GO:0042169 1.45850402669249e-06 2.54275041634691e-06 695 519.909090909091 520 1.32591363056175e-07 147 1.94847093038168 -1.65076290288981 -1 11.6333446012531 694 293 362 147 520 707 839 818 361 284 694 553 M19126 GO_OPSONIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPSONIN_BINDING.html Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. 16/21 Gene Ontology MF GO:0001846 1.0526024410308e-05 1.31610914142416e-05 245 508.818181818182 520 9.56915888454942e-07 139 1.29396433227747 1.26828573263756 1 6.73967897559189 241 826 520 897 732 268 224 139 908 559 283 554 M19139 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. 103/141 Gene Ontology MF GO:0001085 6.18852018101662e-07 1.34545709347279e-06 520 503.181818181818 520 5.62592901984143e-08 333 1.87197814366153 2.33304809680085 1 11.7288823649306 520 655 541 333 408 422 472 438 536 644 566 555 M18285 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 443/695 Gene Ontology MF GO:0000981 2.40647899861371e-07 8.96389104902017e-07 525 545.636363636364 522 2.18770841986131e-08 226 1.8921139810526 2.01948027585748 1 12.2111782674832 522 647 356 782 226 419 457 822 604 455 712 556 M18636 GO_FOUR_WAY_JUNCTION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOUR_WAY_JUNCTION_DNA_BINDING.html Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. 15/18 Gene Ontology MF GO:0000400 2.85727426899256e-05 3.31257393293492e-05 125 448 522 2.59755579893826e-06 113 1.11288732355239 1.17034238128517 1 5.32043547217412 124 765 621 758 793 113 118 156 820 522 138 557 M18507 GO_PHOSPHOTYROSINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTYROSINE_BINDING.html Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. 19/23 Gene Ontology MF GO:0001784 2.55490522600513e-05 2.97696397078025e-05 565 476 523 2.3226680882974e-06 123 1.73412322881669 -2.01139598399867 -1 8.37626364054399 703 562 434 250 788 523 531 364 395 563 123 558 M18974 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 45/73 Gene Ontology MF GO:0016903 1.77620514346672e-07 8.37618242795071e-07 500 513.181818181818 524 1.61473207897409e-08 170 2.18184801968038 -2.42731551271181 -1 14.1496143315281 496 665 304 635 170 543 431 659 703 515 524 559 M19003 GO_GLUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 15/16 Gene Ontology MF GO:0046527 2.23228337121742e-05 2.63763406010856e-05 290 470 524 2.02936911085814e-06 35 2.03000366514694 2.43833067342163 1 9.91930505854818 289 822 519 531 777 547 753 87 35 524 286 560 M19099 GO_PURINERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_ACTIVITY.html Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 14/26 Gene Ontology MF GO:0035586 1.78555276716336e-07 8.37618242795071e-07 860 484.727272727273 524 1.62322992007409e-08 68 2.93653945070342 3.01613874942005 1 19.0439033628226 746 153 104 181 173 760 856 908 524 68 859 561 M18431 GO_OXYGEN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORTER_ACTIVITY.html Enables the directed movement of oxygen into, out of or within a cell, or between cells. 4/17 Gene Ontology MF GO:0005344 8.21770725573214e-05 8.99663685343187e-05 390 553.545454545455 525 8.21801115975552e-06 246 1.96318834866448 -2.09765638965761 -1 8.4764371731612 390 525 857 499 842 487 246 552 796 361 534 562 M19201 GO_THIOESTERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTERASE_BINDING.html Interacting selectively and non-covalently with any thioesterase enzyme. 15/16 Gene Ontology MF GO:0031996 6.41299423251181e-06 8.55065897668242e-06 630 545 525 5.8300117513177e-07 241 1.53595152071443 -1.47546807428771 -1 8.30707737685147 626 329 512 416 684 708 870 445 241 525 639 563 M18047 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS.html Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). 52/68 Gene Ontology MF GO:0016765 1.13722787672175e-06 2.08078922394237e-06 745 584 526 1.0338440587091e-07 333 1.36279677652515 -1.53020872701166 -1 8.26321395759145 465 743 614 739 492 453 512 333 805 742 526 564 M18301 GO_FOLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_BINDING.html Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 11/12 Gene Ontology MF GO:0005542 9.833645010118e-06 1.24469698484233e-05 530 484.727272727273 526 8.93971724109046e-07 36 2.97494069322724 2.57635115231556 1 15.5720526875406 526 183 205 139 724 676 910 829 36 265 839 565 M18456 GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. 172/211 Gene Ontology MF GO:0004721 2.05021091316644e-07 8.48926288617081e-07 620 526.272727272727 527 1.86382827657137e-08 200 1.82943399563195 2.09383214395393 1 11.8527856087457 620 380 428 624 200 460 505 853 551 527 641 566 M18726 GO_GABA_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_ACTIVITY.html Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. 3/22 Gene Ontology MF GO:0016917 5.31381483019771e-06 7.37231967432835e-06 545 494.909090909091 527 5.31382753672308e-07 253 3.14237675881749 2.36106708916725 1 17.2112566618612 545 527 875 309 667 451 267 671 256 253 623 567 M18816 GO_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a growth factor receptor. 122/186 Gene Ontology MF GO:0070851 4.24554840395536e-07 1.11129935559625e-06 335 511.818181818182 529 3.85959020296298e-08 239 2.11169868826721 2.08595755576696 1 13.4179838613629 505 532 239 628 332 564 391 717 529 333 860 568 M18942 GO_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 11/22 Gene Ontology MF GO:0016502 2.22853106564145e-07 8.642517439673e-07 540 432.545454545455 530 2.02593753762244e-08 89 3.19095437519309 -2.84367360220069 -1 20.6475308912465 547 336 116 348 216 538 538 903 530 89 597 569 M18497 GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 87/96 Gene Ontology MF GO:0004702 8.02711301425456e-08 8.2820001624993e-07 535 516.363636363636 531 7.29737573376258e-09 24 1.62271396130949 -1.89312873097679 -1 10.5320489500189 531 539 559 502 24 513 644 838 319 686 525 570 M19047 GO_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEAMINASE_ACTIVITY.html Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). 23/28 Gene Ontology MF GO:0019239 5.84642424960483e-07 1.30124638129901e-06 920 549.272727272727 532 5.31493254842956e-08 120 2.23744352610593 2.2067073298323 1 14.0533537290706 919 486 353 678 397 779 532 367 120 599 812 571 M18807 GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in). 7/12 Gene Ontology MF GO:0043225 1.6368636701312e-05 1.97449351331753e-05 885 510.545454545455 535 1.63687572720823e-06 4 3.28544860912707 -5.50968592403495 -1 16.4947758857737 883 356 884 54 767 870 841 104 4 535 318 572 M18321 GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. 47/81 Gene Ontology MF GO:0004715 1.0606362976016e-05 1.32436207970794e-05 715 612.727272727273 536 9.64219464583883e-07 388 2.02613028173034 -1.58295150205899 -1 10.547334047019 714 472 388 536 733 826 894 480 451 501 745 573 M17991 GO_FATTY_ACYL_COA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_BINDING.html Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. 31/35 Gene Ontology MF GO:0000062 1.65924863076638e-07 8.2829858135462e-07 540 565.454545454545 538 1.50840795991597e-08 159 1.03381229431652 -0.954088045682998 -1 6.70978850900967 538 751 696 889 159 299 427 441 815 798 407 574 M18926 GO_INORGANIC_ANION_EXCHANGER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_EXCHANGER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). 7/24 Gene Ontology MF GO:0005452 0.00054104825947536 0.000567455836271547 125 499.363636363636 538 5.41180034580758e-05 125 1.25691528356312 1.40261774417036 1 4.35409181259277 125 582 899 596 877 168 150 538 842 411 305 575 M19011 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery. 93/114 Gene Ontology MF GO:0001104 1.0865483952435e-07 8.2820001624993e-07 280 468.636363636364 538 9.8777131718779e-09 66 1.62670278882075 1.68547233664286 1 10.5579380092904 280 538 602 657 66 282 351 611 634 743 391 576 M18319 GO_RRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. 15/16 Gene Ontology MF GO:0008649 1.70390479321149e-06 2.86777418748164e-06 200 437.363636363636 539 1.54900555717354e-07 18 0.973468789695663 0.823064847837955 1 5.75782222576405 198 703 650 751 539 47 18 258 784 674 189 577 M18956 GO_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_BINDING.html Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 457/607 Gene Ontology MF GO:0003682 1.03355468774712e-06 1.93320755359989e-06 250 577.727272727273 539 9.39595612099036e-08 250 1.61022455300507 1.60346931798533 1 9.81837561306039 250 786 750 860 479 360 379 486 598 868 539 578 M19210 GO_HEXOSAMINIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSAMINIDASE_ACTIVITY.html Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. 15/18 Gene Ontology MF GO:0015929 3.34826065778713e-07 9.67001407265299e-07 815 548.090909090909 540 3.04387378851937e-08 163 1.14948557411392 -1.01868610351711 -1 7.37806377883725 815 163 540 865 296 468 399 612 706 358 807 579 M18906 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. 27/30 Gene Ontology MF GO:0031435 1.02347051561615e-06 1.91822871486678e-06 415 537.363636363636 541 9.30428174317398e-08 254 1.06376497471517 -1.24832912891227 -1 6.49016159528017 541 412 655 254 478 614 830 572 412 768 375 580 M17880 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. 38/59 Gene Ontology MF GO:0016620 2.48534802767136e-07 9.05170150212826e-07 490 536 542 2.25940755312916e-08 232 2.36206627280149 -2.66347344753437 -1 15.2334486761163 523 670 261 631 232 561 489 823 676 488 542 581 M18020 GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding. 18/22 Gene Ontology MF GO:0044183 0.000351965944533443 0.000372101296051374 255 537.363636363636 542 3.2002024204679e-05 212 1.38545881322245 1.62503260062647 1 5.07035101431355 255 699 542 328 871 359 212 716 829 786 314 582 M18013 GO_LEUCINE_ZIPPER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUCINE_ZIPPER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. 11/14 Gene Ontology MF GO:0043522 1.40823808583061e-05 1.71890619723578e-05 750 494.727272727273 543 1.28022463650832e-06 134 0.812310186174251 0.932350131016929 1 4.13043483906502 134 575 609 543 750 237 171 424 832 750 417 583 M18561 GO_LRR_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LRR_DOMAIN_BINDING.html Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. 21/25 Gene Ontology MF GO:0030275 2.68457402890126e-05 3.11626432500599e-05 150 427.272727272727 543 2.44055162569883e-06 114 1.24434823047587 1.4027798062418 1 5.98414924779356 148 563 601 654 792 175 114 136 543 779 195 584 M18690 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 181/280 Gene Ontology MF GO:0001077 2.37530216974331e-07 8.88574576859441e-07 225 507.545454545455 543 2.15936584200058e-08 224 2.10108624534731 2.3657958398364 1 13.5683540079133 543 596 224 700 225 408 303 771 633 301 879 585 M18280 GO_POLY_PURINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PURINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. 24/29 Gene Ontology MF GO:0070717 0.00111632252331788 0.00116683485468973 120 520 544 0.000101535397242233 116 1.40041091910287 1.58520587987328 1 4.38328927995715 116 758 651 544 881 356 205 352 624 804 429 586 M18384 GO_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any phosphatase. 212/251 Gene Ontology MF GO:0019902 5.54391823940356e-07 1.26879706209363e-06 755 563.545454545455 544 5.03992694222805e-08 374 1.79211258526653 -1.72896118412563 -1 11.2772103124417 751 374 446 422 384 726 921 586 480 565 544 587 M18419 GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. 18/23 Gene Ontology MF GO:0070003 0.0131633622169172 0.0134694869196362 155 544.545454545455 545 0.00120388993738017 154 1.34384239486984 -1.34384239486984 -1 2.68271431315242 154 702 686 545 910 397 340 395 605 788 468 588 M18049 GO_POLY_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_BINDING.html Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. 17/22 Gene Ontology MF GO:0008143 0.00630308475577395 0.00645681853030503 175 534.090909090909 546 0.000574656009459563 172 1.50145656573732 1.7140596496903 1 3.50903020384416 172 771 629 546 899 385 225 417 622 778 431 589 M18111 GO_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with an identical protein to form a homodimer. 729/1017 Gene Ontology MF GO:0042803 9.76146859123607e-08 8.2820001624993e-07 800 455 547 9.76146902002430e-09 62 2.0141047978927 -1.91122110527119 -1 13.072329405375 796 229 825 122 62 600 761 693 304 66 547 590 M18182 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS.html Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. 42/47 Gene Ontology MF GO:0016706 3.12346185685363e-05 3.5986019398164e-05 345 495.636363636364 547 2.83955109386649e-06 117 1.73566016279533 2.00225131606932 1 8.23113592305621 344 803 547 533 798 569 589 117 303 696 153 591 M18199 GO_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 25/52 Gene Ontology MF GO:0005504 1.26499848014798e-07 8.2820001624993e-07 855 497.636363636364 547 1.1499986844412e-08 91 2.32552499099912 -2.4970487751934 -1 15.0935689337647 854 112 187 281 91 897 795 725 547 293 692 592 M18402 GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 38/46 Gene Ontology MF GO:0008138 2.2350911948711e-07 8.642517439673e-07 575 465.454545454545 547 2.03190129267759e-08 83 1.32684277030206 -1.41750013612144 -1 8.58552601342493 575 83 617 579 217 544 873 190 657 547 238 593 M18901 GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING.html Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. 16/17 Gene Ontology MF GO:0043560 2.78543400443135e-07 9.30984999064807e-07 860 556.272727272727 550 2.53221305190635e-08 193 1.34500812686964 -1.04337244292561 -1 8.65670217069501 860 505 508 289 255 770 801 550 193 634 754 594 M18368 GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a protein serine/threonine kinase. 33/35 Gene Ontology MF GO:0030291 5.720950233513e-07 1.28304806207913e-06 620 534.909090909091 552 5.20086520109791e-08 393 1.87057289237802 1.74804857696081 1 11.7612536902121 619 552 444 574 393 752 566 459 405 495 625 595 M18043 GO_DNA_N_GLYCOSYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_N_GLYCOSYLASE_ACTIVITY.html Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. 15/17 Gene Ontology MF GO:0019104 4.44738704525085e-05 5.02369881395083e-05 520 582.181818181818 553 4.04316086680379e-06 419 1.60738383657721 1.57201326939417 1 7.37426508816151 516 570 464 419 812 549 535 553 612 603 771 596 M18603 GO_SPECTRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECTRIN_BINDING.html Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. 29/40 Gene Ontology MF GO:0030507 5.32340001794056e-07 1.2358848282857e-06 380 511.909090909091 553 4.83945573278057e-08 61 1.94338896750163 1.93857052979195 1 12.2528182155636 795 553 379 183 377 771 772 653 61 277 810 597 M18104 GO_HYDRO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDRO_LYASE_ACTIVITY.html Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. 44/52 Gene Ontology MF GO:0016836 1.5816491364756e-07 8.2820001624993e-07 400 516.272727272727 554 1.43786295471395e-08 148 1.61660505521535 -1.43866115839228 -1 10.4923997469614 554 398 436 686 148 603 674 632 495 396 657 598 M18793 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin-like growth factor receptor. 17/26 Gene Ontology MF GO:0005159 2.0312885439056e-05 2.4124815097285e-05 715 500.636363636364 555 1.84664299936247e-06 57 1.08638875705404 1.27571525725252 1 5.35339855123662 188 762 555 711 772 295 198 374 881 714 57 599 M19028 GO_GTP_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. 19/22 Gene Ontology MF GO:0030742 1.94888084335122e-06 3.19284733910733e-06 80 434.636363636364 555 1.77171142707188e-07 22 0.997265128074878 -0.997265128074878 -1 5.8489421052163 80 761 670 800 555 40 22 165 878 693 117 600 M18263 GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). 27/47 Gene Ontology MF GO:0016303 2.13984581974957e-06 3.46880269727826e-06 910 565 556 1.94531627371712e-07 100 2.15724731754878 -2.30566171800755 -1 12.5693393270009 906 556 326 417 560 907 694 503 100 710 536 601 M18520 GO_SUMO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_BINDING.html Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. 15/17 Gene Ontology MF GO:0032183 0.002432995159566 0.00251463929243734 560 599.090909090909 556 0.000221426363540006 173 1.78992188215224 2.68731625275878 1 4.96548832716189 556 907 491 887 915 609 490 279 173 799 484 602 M18278 GO_PEPTIDASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 42/51 Gene Ontology MF GO:0016504 9.39782593181965e-07 1.81665087050238e-06 595 549.181818181818 557 8.54348176938916e-08 277 1.67967954003469 -1.66973827276738 -1 10.2902891122019 592 746 537 506 463 557 635 562 426 740 277 603 M18344 GO_NUCLEOTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDASE_ACTIVITY.html Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. 13/15 Gene Ontology MF GO:0008252 2.00716580301712e-06 3.27093686417605e-06 540 556.818181818182 557 1.82469784932123e-07 147 1.34426285606403 1.86184246603212 1 7.86902427521719 540 569 522 728 557 921 667 318 147 637 519 604 M19136 GO_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. 58/60 Gene Ontology MF GO:0003678 4.3303055508905e-05 4.92082030345593e-05 70 460.727272727273 557 3.93671889776371e-06 68 1.21711339564334 1.32620854843279 1 5.59547538779452 68 607 708 664 807 138 152 365 731 557 271 605 M18281 GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within. 10/13 Gene Ontology MF GO:0044213 1.03382593414289e-05 1.30321304658667e-05 560 507 559 9.39846174853426e-07 191 1.00440808863702 -1.10557664876421 -1 5.23609379432401 559 191 564 286 726 617 845 254 527 723 285 606 M18298 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 131/168 Gene Ontology MF GO:0001076 1.26160144858835e-07 8.2820001624993e-07 345 502.727272727273 562 1.14691047357777e-08 90 1.62196058472896 1.59499897537691 1 10.5271592397238 341 599 636 548 90 247 353 739 687 728 562 607 M18661 GO_MAP_KINASE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. 13/14 Gene Ontology MF GO:0033549 1.92073805670123e-07 8.40700906161521e-07 925 514.363636363636 563 1.74612565853975e-08 166 1.59719183707375 1.3133651755837 1 10.3553105154832 924 166 337 563 187 894 875 174 662 260 616 608 M18695 GO_PROTEIN_PHOSPHATASE_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_1_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 1. 19/30 Gene Ontology MF GO:0008157 6.2856406278199e-07 1.3569934439499e-06 425 541.181818181818 564 5.714220385179e-08 350 1.33093570225492 -1.82392349988902 -1 8.33371271029312 422 564 506 699 412 610 491 621 648 630 350 609 M18727 GO_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. 83/87 Gene Ontology MF GO:0008094 2.61648668257675e-05 3.04487870869133e-05 45 423.181818181818 565 2.37865254662577e-06 21 1.31717964319514 1.39127217440157 1 6.34854721588261 21 657 699 667 790 43 44 275 565 676 218 610 M18113 GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. 33/37 Gene Ontology MF GO:0045309 2.14710908112735e-06 3.47448124511676e-06 565 596.818181818182 566 1.95191925147267e-07 332 1.61267715269068 -1.99357166431988 -1 9.39514319591806 825 677 566 421 561 748 765 332 563 659 448 611 M18205 GO_SINGLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with single-stranded RNA. 96/138 Gene Ontology MF GO:0003727 6.8972957698807e-06 9.10443041624253e-06 150 494.545454545455 566 6.27028853993194e-07 115 1.56719603018755 1.46935211553966 1 8.43048092432341 149 731 579 745 691 194 115 495 566 689 486 612 M18548 GO_LIPOPOLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with lipopolysaccharide. 19/32 Gene Ontology MF GO:0001530 1.62232416132404e-06 2.76403772238001e-06 670 505.727272727273 566 1.47484123423607e-07 161 2.77183001226791 -2.46601951269122 -1 16.442011472956 667 689 161 566 529 429 182 588 709 249 794 613 M19192 GO_ARMADILLO_REPEAT_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARMADILLO_REPEAT_DOMAIN_BINDING.html Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. 17/19 Gene Ontology MF GO:0070016 8.25398635275877e-06 1.0651792444063e-05 570 512 566 7.50365210938755e-07 117 1.5912731320008 1.40069296941303 1 8.44423637214881 566 632 518 361 708 597 444 243 117 715 731 614 M18091 GO_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. 564/710 Gene Ontology MF GO:0004672 3.23485343814525e-07 9.51261405195598e-07 470 542 567 3.2348539090378e-08 306 1.89460719117634 2.16914371573084 1 12.175097798843 468 646 822 567 306 595 573 505 416 474 590 615 M18262 GO_DAMAGED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DAMAGED_DNA_BINDING.html Interacting selectively and non-covalently with damaged DNA. 67/77 Gene Ontology MF GO:0003684 1.84012034078824e-06 3.0635517025015e-06 380 551.636363636364 567 1.67283807263676e-07 378 1.44965229915785 1.46399904505458 1 8.52995974055313 378 662 573 607 545 435 522 397 567 701 681 616 M18880 GO_DRUG_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORTER_ACTIVITY.html Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 23/30 Gene Ontology MF GO:0090484 2.48823829171058e-07 9.05170150212826e-07 600 580.181818181818 567 2.2620350664861e-08 233 2.54493638168124 2.58233116404438 1 16.412815643596 598 688 303 537 233 567 467 910 738 513 828 617 M17980 GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. 5/15 Gene Ontology MF GO:0047555 0.000670486624512565 0.000702414559013164 915 619.545454545455 568 6.7068900899985e-05 201 2.97428517137524 2.61850218665473 1 10.0091384074126 846 461 808 277 879 568 525 911 201 428 911 618 M18206 GO_CATECHOLAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BINDING.html Interacting selectively and non-covalently with catecholamine. 5/17 Gene Ontology MF GO:1901338 5.21020335907815e-07 1.22499437755425e-06 605 475.818181818182 569 5.21020458065841e-08 168 3.33885463108215 3.70755100857243 1 21.0647486432132 605 214 834 241 394 584 696 660 269 168 569 619 M18492 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein receptor. 13/20 Gene Ontology MF GO:0050750 1.57216704050986e-05 1.90548314023125e-05 760 505.272727272727 569 1.42925297787645e-06 111 1.02147254328159 1.12232208710745 1 5.14519975742566 130 775 569 760 757 152 111 472 716 832 284 620 M18741 GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the directed movement of water (H2O) from one side of a membrane to the other. 7/14 Gene Ontology MF GO:0005372 2.87984898115448e-07 9.30984999064807e-07 285 516.181818181818 570 2.8798493543634e-08 123 4.77126787749222 5.25941806983698 1 30.7087027158079 618 211 878 123 282 820 922 824 149 281 570 621 M18858 GO_GTP_RHO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_RHO_BINDING.html Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. 20/21 Gene Ontology MF GO:0017049 3.15351736934458e-05 3.62870491814992e-05 215 498.454545454545 570 2.86687506664123e-06 186 1.41320041721341 -1.55716704742413 -1 6.69645705965671 212 692 570 792 799 294 336 267 741 594 186 622 M19122 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. 17/18 Gene Ontology MF GO:0015095 1.04221308974001e-05 1.30871252888307e-05 920 564.727272727273 570 9.47470933711287e-07 282 1.60111450867611 1.44756635619261 1 8.3436691541848 918 323 368 570 728 823 690 300 282 651 559 623 M18343 GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE.html The action of a molecule that contributes to the structural integrity of the nuclear pore complex. 14/14 Gene Ontology MF GO:0017056 7.51932494654425e-05 8.27125744119868e-05 60 472.090909090909 571 6.83598359997108e-06 8 0.616331379454662 0.616331379454662 1 2.68513829119583 57 571 667 658 832 80 8 261 883 840 336 624 M18770 GO_TRANSCRIPTION_COACTIVATOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_BINDING.html Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 11/12 Gene Ontology MF GO:0001223 0.000161771627005754 0.000174293328788789 610 584.363636363636 572 1.47075930647261e-05 370 2.18311618415731 1.84717333510401 1 8.75690925214633 608 572 370 420 853 562 482 738 544 582 697 625 M18592 GO_DYNEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_BINDING.html Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. 37/55 Gene Ontology MF GO:0045502 1.49581442958138e-06 2.59311919874895e-06 675 597.545454545455 573 1.35983222419089e-07 493 1.70817512260353 1.26556545695162 1 10.1831293061575 742 673 493 584 524 573 564 556 533 672 659 626 M18178 GO_CIS_TRANS_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_TRANS_ISOMERASE_ACTIVITY.html Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. 36/44 Gene Ontology MF GO:0016859 0.0018427049040229 0.00191310037226648 355 614.272727272727 575 0.000167659104846941 354 1.68585310422767 1.85052201421062 1 4.89040790683243 354 877 575 789 886 497 664 392 526 702 495 627 M18987 GO_2_IRON_2_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_IRON_2_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. 24/29 Gene Ontology MF GO:0051537 2.26916179725021e-06 3.62751816723044e-06 505 589.636363636364 575 2.06287648886494e-07 425 1.52629827298054 -1.4411766942909 -1 8.86142556480708 425 757 600 794 569 575 516 579 504 666 501 628 M19005 GO_P53_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_P53_BINDING.html Interacting selectively and non-covalently with one of the p53 family of proteins. 81/92 Gene Ontology MF GO:0002039 6.73210426400971e-07 1.41696226422437e-06 520 626.181818181818 575 6.12009665824218e-08 426 1.45622608859682 1.89265391689679 1 9.08903850681865 518 855 687 774 426 539 575 547 600 838 529 629 M18886 GO_TRANSLATION_REPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REPRESSOR_ACTIVITY.html Antagonizes ribosome-mediated translation of mRNA into a polypeptide. 18/22 Gene Ontology MF GO:0030371 7.99287365483535e-07 1.60552505588432e-06 580 577.909090909091 577 7.26625141704294e-08 339 1.46126809421601 -0.925591874655343 -1 9.03589573794805 690 697 533 496 448 628 577 577 339 608 764 630 M18204 GO_NADPH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADPH_BINDING.html Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. 12/16 Gene Ontology MF GO:0070402 2.54411575009233e-06 4.004706904745e-06 770 581.636363636364 579 2.31283517468535e-07 341 1.36114972339444 -1.0703807411744 -1 7.84019664342857 770 341 524 500 579 587 607 730 424 415 921 631 M18639 GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. 9/11 Gene Ontology MF GO:0051766 0.000150521174779086 0.00016247846436434 495 661.636363636364 579 1.50531371231954e-05 409 0.759619187827466 0.79015804703655 1 3.07169286259807 495 579 872 514 856 555 409 702 889 919 488 632 M19100 GO_CARBON_OXYGEN_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_OXYGEN_LYASE_ACTIVITY.html Catalysis of the breakage of a carbon-oxygen bond. 65/77 Gene Ontology MF GO:0016835 1.36648142508467e-07 8.2820001624993e-07 640 508.363636363636 579 1.24225591814605e-08 42 1.58834790321619 -1.4764328041389 -1 10.3089997175326 579 42 452 884 111 636 676 697 466 409 640 633 M17952 GO_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 28/38 Gene Ontology MF GO:0019212 5.36175919268256e-06 7.40547906433286e-06 580 559.454545454545 580 4.87433841837246e-07 325 1.87663617287567 -2.14194727232503 -1 10.2747061352232 580 413 416 634 656 687 471 797 325 568 607 634 M18028 GO_MIRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIRNA_BINDING.html Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. 15/25 Gene Ontology MF GO:0035198 0.00114520063304326 0.00119566710161805 175 565.363636363636 581 0.000104163381559693 84 1.52273561434588 1.53024652638058 1 4.74893944068472 174 774 545 765 882 302 84 564 795 753 581 635 M18868 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. 6/29 Gene Ontology MF GO:0015347 1.35574080814779e-05 1.66141181263734e-05 875 541.454545454545 582 1.35574907936793e-06 3 4.07196706034182 -6.62528644647984 -1 20.769353593844 875 359 888 84 753 916 855 293 3 348 582 636 M17900 GO_QUINONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_BINDING.html Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. 14/20 Gene Ontology MF GO:0048038 3.62461466753817e-06 5.37583299005661e-06 570 522.545454545455 583 3.29510967208502e-07 206 2.71906693949041 -3.02875859010327 -1 15.2907205544704 569 568 328 632 612 583 603 457 206 587 603 637 M18485 GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of modified amino acids from one side of a membrane to the other. 12/17 Gene Ontology MF GO:0072349 3.57167338286537e-06 5.30582991280965e-06 870 552.818181818182 583 3.2469810740428e-07 189 1.7972368673292 1.70593464460592 1 10.1177099179524 868 189 321 636 611 904 385 583 726 315 543 638 M18737 GO_ANION_ANION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_ANION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). 13/29 Gene Ontology MF GO:0015301 2.27403873022914e-05 2.68225622788462e-05 585 540.454545454545 583 2.06732930569171e-06 172 1.42946426959189 -1.45606755403906 -1 6.9737452876255 583 172 405 497 778 545 689 592 770 261 653 639 M18985 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. 13/17 Gene Ontology MF GO:0005337 9.5777809427241e-07 1.83988972787465e-06 900 633.181818181818 583 8.70707737495345e-08 161 1.32616338822471 1.03743071925831 1 8.11671552531758 897 442 500 583 467 848 898 161 809 551 809 640 M18462 GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. 22/35 Gene Ontology MF GO:0004033 2.80519113455814e-07 9.30984999064807e-07 650 560.909090909091 584 2.55017408385859e-08 257 1.94754664861473 -2.58705011127411 -1 12.5347443441058 646 419 318 575 257 630 727 690 758 566 584 641 M18797 GO_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. 547/803 Gene Ontology MF GO:0008134 4.55993273156933e-07 1.16714067700002e-06 885 644.090909090909 585 4.55993366725399e-08 358 1.6221038308707 1.77559705048541 1 10.270181382142 482 921 883 881 358 439 526 593 553 864 585 642 M18962 GO_MAP_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_ACTIVITY.html Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. 16/17 Gene Ontology MF GO:0004708 2.66234470150423e-07 9.26593111473573e-07 635 507.363636363636 585 2.42031365789973e-08 108 1.81042143524223 -1.50171296567564 -1 11.656150394738 759 430 460 112 247 776 834 585 108 635 635 643 M18595 GO_RAGE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAGE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. 5/18 Gene Ontology MF GO:0050786 1.53226672376656e-06 2.65133792651742e-06 625 639 586 1.53226778029618e-07 327 1.92199363383271 1.27980892300945 1 11.4380111875276 622 586 869 507 536 580 825 855 893 429 327 644 M18922 GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING.html Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. 18/24 Gene Ontology MF GO:0031683 2.31465292923565e-05 2.72104237482664e-05 590 552.454545454545 587 2.10425207491299e-06 183 2.69398326164132 2.78967466456871 1 13.1248701781634 587 763 404 577 781 727 794 262 328 671 183 645 M19081 GO_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 566/838 Gene Ontology MF GO:0016491 9.56786680604482e-08 8.2820001624993e-07 300 519.272727272727 587 9.56786721799318e-09 58 1.8183867920585 -1.77991990136488 -1 11.8020425756623 299 591 912 777 58 374 392 600 470 652 587 646 M19084 GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING.html Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. 313/461 Gene Ontology MF GO:0001159 1.69475299554069e-06 2.85757621875839e-06 590 592.909090909091 588 1.54068572825634e-07 418 1.91231886452734 2.20636045415147 1 11.3140435642802 588 720 418 601 537 718 592 587 518 553 690 647 M17850 GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 54/77 Gene Ontology MF GO:0004712 4.22886561285827e-06 6.10542472856413e-06 385 570.545454545455 589 3.84443067423169e-07 330 1.75493113235261 2.03776975316523 1 9.7653743842246 382 741 535 755 631 505 330 589 347 725 736 648 M18112 GO_POLY_PYRIMIDINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PYRIMIDINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. 21/26 Gene Ontology MF GO:0008187 2.68438592523952e-06 4.15472796469232e-06 590 544.272727272727 589 2.44035381878804e-07 319 1.26328379652588 1.51285321243757 1 7.2549582450163 345 490 589 733 589 524 319 629 640 537 592 649 M18434 GO_BETA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. 39/46 Gene Ontology MF GO:0048487 4.60460980245043e-07 1.17136440955838e-06 750 555.818181818182 591 4.18600978745235e-08 285 1.57949966910933 -1.17678010480189 -1 9.99779309968168 747 669 618 509 341 492 504 614 285 744 591 650 M17895 GO_OXALATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. 6/11 Gene Ontology MF GO:0019531 0.00023621492534107 0.000251454597943719 535 635.545454545455 592 2.36240037968999e-05 345 1.30388503144383 -1.50753396222864 -1 5.00864628239425 534 584 803 592 866 532 629 670 909 345 527 651 M19110 GO_NUCLEOTIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. 25/28 Gene Ontology MF GO:0019201 2.28977137962508e-05 2.6952213436606e-05 905 603 592 2.08163201093755e-06 294 1.87188914011138 -1.09279091536325 -1 9.1279646585308 905 308 426 415 780 781 901 514 592 294 717 652 M18267 GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY.html Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. 20/26 Gene Ontology MF GO:0004012 4.49184751114559e-06 6.44482468990454e-06 555 558.636363636364 593 4.0835060749058e-07 222 2.13770267255961 -1.83753822386333 -1 11.8417207902105 552 421 300 587 635 593 628 762 800 222 645 653 M19015 GO_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. 6/13 Gene Ontology MF GO:0015116 0.00023621492534107 0.000251454597943719 535 645.363636363636 593 2.36240037968999e-05 349 1.30388503144383 -1.50753396222864 -1 5.00864628239425 535 585 905 593 867 533 630 664 910 349 528 654 M18634 GO_3_5_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_DNA_HELICASE_ACTIVITY.html Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. 13/13 Gene Ontology MF GO:0043138 4.97910594742349e-05 5.59015054121423e-05 445 610.272727272727 594 4.52656239964775e-06 404 1.29656017783649 1.46923141041044 1 5.88408391770812 443 708 594 512 817 624 848 560 653 550 404 655 M17922 GO_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. 33/35 Gene Ontology MF GO:0034061 4.10552014962028e-06 5.98343946096079e-06 400 538.181818181818 595 3.73229801012577e-07 339 1.12809131721212 1.14188323372735 1 6.28785362282437 400 674 653 595 625 345 339 372 744 755 418 656 M18399 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS.html Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). 210/262 Gene Ontology MF GO:0016746 5.51419043236697e-07 1.26879706209363e-06 475 587.545454545455 595 5.01290164951984e-08 357 1.37071603751164 -1.57444461779344 -1 8.62549148111286 473 595 766 798 382 521 638 357 651 850 432 657 M18853 GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). 10/18 Gene Ontology MF GO:0016775 4.33500836256832e-05 4.92082030345593e-05 625 517.181818181818 595 3.94099434950811e-06 25 1.99637278709003 -1.94544654037862 -1 9.17799199905384 625 349 358 146 808 684 595 734 25 544 821 658 M19222 GO_SNORNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_BINDING.html Interacting selectively and non-covalently with small nucleolar RNA. 28/31 Gene Ontology MF GO:0030515 0.000191644688212545 0.000204953347116194 170 532.727272727273 596 1.742376224107e-05 170 1.14414761665758 1.06797790817911 1 4.50347313336507 170 679 643 747 862 263 203 411 596 803 483 659 M18364 GO_DIACYLGLYCEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_BINDING.html Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. 11/14 Gene Ontology MF GO:0019992 1.23938047609576e-05 1.5351039677111e-05 825 575.636363636364 597 1.12671587114524e-06 254 2.09204445916661 -1.79275732579878 -1 10.7472834680285 823 711 414 442 741 765 597 256 749 580 254 660 M19004 GO_RIBONUCLEASE_P_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_P_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. 10/11 Gene Ontology MF GO:0004526 3.06113542088993e-07 9.36585804272284e-07 495 581.545454545455 599 2.7828507698401e-08 275 0.806748638391479 -0.746130911947001 -1 5.19012832656657 492 453 599 704 275 574 660 356 828 802 654 661 M18999 GO_PROTEIN_N_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 125/154 Gene Ontology MF GO:0047485 3.71374366305325e-06 5.48162802661535e-06 570 608.909090909091 600 3.37613630191808e-07 459 1.78775501430332 2.00166490843231 1 10.0373230848211 699 600 632 459 615 582 569 527 568 810 637 662 M18252 GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS.html Catalysis of the hydrolysis of any ester bond. 622/826 Gene Ontology MF GO:0016788 1.26050498485532e-07 8.2820001624993e-07 605 617.909090909091 601 1.2605050563546e-08 115 1.74467108067312 -1.64724385495021 -1 11.3235986179047 680 462 839 883 115 704 869 601 510 601 533 663 M17940 GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. 36/38 Gene Ontology MF GO:0004003 1.45055325763916e-05 1.76822059374484e-05 115 461.818181818182 603 1.31869347439997e-06 80 1.26560060429283 1.34783870662804 1 6.41873625295846 114 748 675 665 752 144 80 388 603 658 253 664 M19069 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC.html Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 16/18 Gene Ontology MF GO:0000983 2.48060688778959e-07 9.05170150212826e-07 675 522.818181818182 603 2.25509742499101e-08 231 2.0169061440579 -1.71145678113966 -1 13.0074399706756 603 433 336 290 231 674 709 791 626 387 671 665 M17862 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase. 30/31 Gene Ontology MF GO:0051019 2.63948950027725e-06 4.11974374705435e-06 855 610.636363636364 606 2.39953878823408e-07 413 1.64291731934152 -1.93918813082719 -1 9.44160890699317 852 555 511 452 584 767 606 619 413 706 652 666 M17943 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION.html Any protein binding that is involved in cell adhesion. 18/21 Gene Ontology MF GO:0098631 7.58532578307831e-07 1.54448131377865e-06 805 555 607 6.89575308945943e-08 271 2.44960430655108 -1.97587247077574 -1 15.1913800366152 607 494 271 343 439 652 805 648 755 288 803 667 M18571 GO_FERROUS_IRON_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERROUS_IRON_BINDING.html Interacting selectively and non-covalently with ferrous iron, Fe(II). 23/29 Gene Ontology MF GO:0008198 1.50198416094554e-05 1.826096532518e-05 635 537.090909090909 607 1.3654494685372e-06 103 2.49985361788183 2.12218790863705 1 12.6411750499912 633 683 377 356 755 607 585 533 103 646 630 668 M19109 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS.html Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). 48/59 Gene Ontology MF GO:0016763 8.97034216179841e-06 1.14483372341184e-05 610 608.909090909091 608 8.154889761758e-07 116 1.65180073319914 -1.06440191360677 -1 8.71022274556891 756 608 606 490 717 866 916 861 189 573 116 669 M19212 GO_MRNA_3_UTR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_UTR_BINDING.html Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. 54/64 Gene Ontology MF GO:0003730 3.39471732337817e-06 5.07559677475959e-06 220 604.636363636364 608 3.08611141965395e-07 220 1.19641949357529 1.27551181244263 1 6.75995121995453 220 863 727 879 608 470 243 471 810 785 575 670 M18539 GO_CAMP_RESPONSE_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_RESPONSE_ELEMENT_BINDING.html Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. 14/16 Gene Ontology MF GO:0035497 3.290859504162e-05 3.78203256448468e-05 205 524 609 2.99173521032527e-06 202 0.950597963395242 -0.962055633362569 -1 4.48617880025622 202 706 628 609 800 243 226 454 892 731 273 671 M18304 GO_GLUCOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_BINDING.html Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. 12/16 Gene Ontology MF GO:0005536 1.64352200472885e-05 1.9773624119394e-05 435 628.909090909091 610 1.49412207534371e-06 328 1.48293283564963 -1.57487635772239 -1 7.44414661207811 842 910 557 790 761 512 433 435 740 610 328 672 M18723 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. 28/32 Gene Ontology MF GO:0016538 0.000343181783877355 0.000363230204241324 455 605.636363636364 610 3.12032117352812e-05 356 1.23714451802435 1.31232613482071 1 4.54140138671946 454 681 658 610 870 431 356 559 816 727 500 673 M18443 GO_RNA_POLYMERASE_CORE_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_CORE_ENZYME_BINDING.html Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. 28/29 Gene Ontology MF GO:0043175 1.55410982457308e-07 8.2820001624993e-07 650 543.272727272727 611 1.41282721305229e-08 144 1.6213398671059 -2.18215410820268 -1 10.5231305382347 648 754 611 455 144 837 710 515 284 774 244 674 M19185 GO_CYTOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a cytokine receptor. 202/377 Gene Ontology MF GO:0005126 3.14913421893138e-07 9.47817595535048e-07 620 488.181818181818 611 2.86284969973301e-08 109 2.16560373076331 2.32694514983721 1 13.9202125058926 611 377 127 617 280 619 645 627 584 109 774 675 M19219 GO_STRUCTURE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. 134/179 Gene Ontology MF GO:0043566 3.26219412419077e-06 4.91723877773618e-06 530 606 611 2.96563541948442e-07 461 1.64087123657537 1.5039912403626 1 9.29527708823099 527 725 586 461 604 611 706 661 467 642 676 676 M17950 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of hydrogen ions from one side of a membrane to the other. 80/114 Gene Ontology MF GO:0015078 5.35897627496025e-05 5.98089772234386e-05 735 504.818181818182 612 4.87191528965863e-06 33 1.26915486624019 -1.23513812834192 -1 5.71997018035433 33 734 746 612 820 238 175 242 735 849 369 677 M18893 GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. 15/18 Gene Ontology MF GO:0042975 3.28371728966092e-06 4.94162015577638e-06 555 652.363636363636 612 2.98520199176686e-07 389 1.23845402308851 -0.939602754275659 -1 7.01280729480691 553 903 612 513 605 680 599 389 736 800 786 678 M18625 GO_DEATH_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). 21/23 Gene Ontology MF GO:0005123 1.74497804299834e-07 8.37618242795071e-07 505 551.545454545455 614 1.58634380127736e-08 168 1.49304160639138 -1.89857625587774 -1 9.68259968863528 504 687 561 639 168 605 625 633 691 614 340 679 M17852 GO_5_3_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_5_3_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. 11/12 Gene Ontology MF GO:0008409 1.64751414898924e-06 2.78300379097999e-06 585 623.090909090909 615 1.49774125705869e-07 439 1.12145257688871 1.10501327544638 1 6.64870486742781 581 573 615 753 534 506 439 676 792 663 722 680 M18370 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. 11/13 Gene Ontology MF GO:0016671 5.44198742302738e-05 6.06561686233692e-05 895 623.090909090909 615 4.94738367487098e-06 195 1.56530261340768 -0.86733918399682 -1 7.04447879732483 894 576 592 446 822 792 615 610 195 664 648 681 M18508 GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the rate of NTP hydrolysis by a NTPase. 334/380 Gene Ontology MF GO:0060589 1.84682282001483e-07 8.37618242795071e-07 905 608.181818181818 615 1.67892997731741e-08 182 1.70334487973085 -1.52008261399045 -1 11.0464484904634 901 367 494 615 182 851 828 917 417 412 706 682 M18874 GO_RAC_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GTPASE_BINDING.html Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. 49/56 Gene Ontology MF GO:0048365 7.83328688652963e-08 8.2820001624993e-07 615 518.818181818182 615 7.12117015040042e-09 17 1.32174667142504 1.37040276275758 1 8.57865287445074 615 61 568 641 17 656 683 695 507 545 719 683 M18096 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. 15/20 Gene Ontology MF GO:0030169 2.32248057631741e-05 2.72677516202959e-05 525 571.363636363636 616 2.111368267709e-06 343 2.50492466278546 -2.30383111493139 -1 12.2013483074234 521 635 343 706 782 616 367 371 733 520 691 684 M18231 GO_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 731/917 Gene Ontology MF GO:0016301 3.25787530568162e-07 9.52619234952475e-07 645 600 616 3.25787578330053e-08 307 1.78997664138273 2.03465179273453 1 11.5015389720205 641 590 837 568 307 725 697 616 452 485 682 685 M18499 GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. 59/77 Gene Ontology MF GO:0000979 2.69356952955212e-07 9.30984999064807e-07 655 587.272727272727 616 2.44869987212664e-08 249 1.69929603187463 1.80279715246164 1 10.9369604239922 758 394 523 549 249 883 662 519 652 616 655 686 M17896 GO_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVITY.html Catalysis of the reaction: GTP + H2O = GDP + phosphate. 232/266 Gene Ontology MF GO:0003924 1.58630687060598e-07 8.2820001624993e-07 585 621.454545454545 618 1.44209725907857e-08 149 1.49998854941154 -1.37724599804753 -1 9.73551276143182 582 922 742 868 149 474 641 618 516 819 505 687 M17935 GO_BHLH_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BHLH_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. 30/36 Gene Ontology MF GO:0043425 5.47235284387037e-07 1.26411350693405e-06 625 612.727272727273 619 4.97486745916547e-08 381 1.28339469754474 -1.1288443520896 -1 8.0782048615595 621 618 622 515 381 520 652 912 768 619 512 688 M17939 GO_METHYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 59/67 Gene Ontology MF GO:0035064 4.06650371969961e-06 5.94533138766209e-06 805 566.363636363636 623 3.6968283966258e-07 272 1.22207544436625 1.46827952009799 1 6.81532961154694 333 798 717 802 623 272 387 377 803 775 343 689 M18040 GO_S_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. 25/29 Gene Ontology MF GO:0016417 8.07295118280479e-06 1.04914302291303e-05 380 552.454545454545 624 7.33907346076288e-07 296 1.12975673668719 -1.1838627011711 -1 6.00309938147696 379 624 679 754 703 372 296 346 747 734 443 690 M18136 GO_GLUCOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. 7/12 Gene Ontology MF GO:0015926 4.82806242333953e-06 6.82129920361732e-06 625 623.545454545455 624 4.82807291295565e-07 341 1.07059384248962 -1.24023343468866 -1 5.90234187274457 624 581 828 590 653 501 341 893 512 647 689 691 M18751 GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY.html Combining with a protein hormone to initiate a change in cell activity. 6/23 Gene Ontology MF GO:0016500 7.23965056241297e-05 7.97310741319379e-05 205 510.818181818182 624 7.239886429659e-06 133 1.03212500171163 -1.03212500171163 -1 4.51416777339361 203 782 879 651 836 205 207 133 920 624 179 692 M17894 GO_PHOSPHOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_BINDING.html Interacting selectively and non-covalently with a phosphorylated protein. 69/84 Gene Ontology MF GO:0051219 2.09378010598017e-07 8.48926288617081e-07 630 571.909090909091 627 1.90343664113551e-08 205 1.73016244042926 1.64209437258873 1 11.2096114108889 627 392 548 253 205 795 908 740 349 656 818 693 M18447 GO_CHROMATIN_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DNA_BINDING.html Interacting selectively and non-covalently with DNA that is assembled into chromatin. 97/136 Gene Ontology MF GO:0031490 6.45938727265122e-06 8.60010639759327e-06 665 582.272727272727 628 5.87218748912733e-07 292 1.76205611978896 -2.00026255312737 -1 9.52523837013937 665 730 536 292 685 550 579 675 422 643 628 694 M18577 GO_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BINDING.html Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. 56/74 Gene Ontology MF GO:0051287 1.34281149215702e-07 8.2820001624993e-07 795 572.363636363636 630 1.22073779465278e-08 53 1.51124165061986 -1.6393540517396 -1 9.80854981388605 794 53 585 735 105 828 844 646 630 478 598 695 M18533 GO_GLUCOCORTICOID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glucocorticoid receptor. 17/19 Gene Ontology MF GO:0035259 7.41866390969867e-06 9.71515511470032e-06 635 601.090909090909 631 6.74426266040128e-07 370 1.27829252244511 -1.13407321829808 -1 6.83790499861411 811 429 486 370 695 635 631 622 767 423 743 696 M19024 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. 46/65 Gene Ontology MF GO:0016860 1.22123290462629e-06 2.19536810092353e-06 600 695.272727272727 632 1.11021234776397e-07 420 0.975640828571762 -1.03675157741989 -1 5.89148488004974 420 871 761 905 503 632 622 597 918 823 596 697 M18940 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 407/490 Gene Ontology MF GO:0004674 3.0414788668802e-07 9.33885678861258e-07 640 603.363636363636 633 2.76498117032892e-08 273 1.73637054904151 1.91498859939958 1 11.1730749608763 637 648 620 633 273 774 701 599 368 627 757 698 M18736 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 93/149 Gene Ontology MF GO:0001078 4.89726430185813e-07 1.21672017060695e-06 795 612 634 4.4520594472762e-08 350 1.85306231490174 2.33938120749638 1 11.6967422353898 634 792 449 791 350 749 580 521 689 661 516 699 M18427 GO_MISMATCHED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCHED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. 11/14 Gene Ontology MF GO:0030983 6.96409271818374e-05 7.68795898638205e-05 500 636.363636363636 635 6.33119379643483e-06 178 0.957113057332067 0.961588317415299 1 4.20224563270886 500 912 635 871 831 450 178 517 900 752 454 700 M18896 GO_K63_LINKED_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_K63_LINKED_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. 18/19 Gene Ontology MF GO:0070530 3.04027937337637e-06 4.63567349999961e-06 600 700.181818181818 638 2.76389415898536e-07 425 1.31707591686848 -1.43061418318942 -1 7.4970209108128 904 425 598 638 598 882 890 760 522 609 876 701 M19033 GO_MISFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with a misfolded protein. 18/19 Gene Ontology MF GO:0051787 0.000202092936218827 0.000215877309903117 530 642.181818181818 640 1.83737729954327e-05 351 1.456716533106 -1.76070424834499 -1 5.69871614347795 530 825 604 371 863 640 653 631 807 789 351 702 M18031 GO_ESTROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an estrogen receptor. 50/56 Gene Ontology MF GO:0030331 8.6404818095405e-06 1.10579019279992e-05 660 648.909090909091 642 7.85501431377087e-07 416 1.33689848150989 -1.23570890927251 -1 7.07118964577007 658 744 671 551 714 642 634 416 601 869 638 703 M18442 GO_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 146/156 Gene Ontology MF GO:0004386 1.17220666273638e-05 1.45580504888228e-05 260 609.818181818182 642 1.06564809868064e-06 256 1.26497081024266 1.3084226317459 1 6.52952199206956 256 726 783 775 739 407 400 642 619 816 545 704 M18032 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 143/223 Gene Ontology MF GO:0001227 5.62426090707587e-07 1.26879706209363e-06 730 649.636363636364 645 5.11296576809881e-08 388 1.81932622265862 2.17471311543923 1 11.4484573602071 628 844 468 867 388 785 728 512 645 726 555 705 M19160 GO_EXODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. 18/19 Gene Ontology MF GO:0004529 2.26477004407638e-06 3.626772132975e-06 635 652.545454545455 645 2.05888397775156e-07 530 1.34532088521281 1.03765545216272 1 7.8108298499295 635 565 538 645 568 714 759 707 655 530 862 706 M17949 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 30/38 Gene Ontology MF GO:0001106 5.67033214627619e-06 7.7735710729365e-06 210 507.545454545455 647 5.15486069197945e-07 133 1.2556140804223 1.15041019460463 1 6.84633910434988 208 808 647 771 661 182 133 194 823 761 395 707 M18522 GO_MANNOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 20/22 Gene Ontology MF GO:0000030 4.53598607024487e-06 6.48579474585974e-06 235 566.181818181818 647 4.12363220238336e-07 98 0.846712903321816 -0.684028274623695 -1 4.68784471595709 233 760 689 796 636 218 98 647 700 843 608 708 M18829 GO_ENZYME_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_REGULATOR_ACTIVITY.html Binds to and modulates the activity of an enzyme. 872/1178 Gene Ontology MF GO:0030234 1.16885235492612e-07 8.2820001624993e-07 705 554.181818181818 647 1.16885241640584e-08 96 2.01631739032284 2.232188211067 1 13.0866900004136 705 227 885 521 96 647 803 718 440 167 887 709 M18173 GO_GLYCINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_BINDING.html Interacting selectively and non-covalently with glycine, aminoethanoic acid. 7/15 Gene Ontology MF GO:0016594 0.0012137194806396 0.0012657751694255 835 605.090909090909 648 0.000121438289239366 174 2.18884619912931 3.04581693531614 1 6.76852848000727 719 834 833 539 884 822 470 421 174 648 312 710 M19037 GO_ACID_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. 10/12 Gene Ontology MF GO:0003993 1.21727418341998e-06 2.19251724265119e-06 835 668.818181818182 648 1.10661350631468e-07 469 1.25958454173771 -1.39202089972285 -1 7.60686101324272 835 778 580 787 502 738 648 469 571 641 808 711 M18317 GO_SNAP_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNAP_RECEPTOR_ACTIVITY.html Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. 34/39 Gene Ontology MF GO:0005484 5.11614776686533e-06 7.16260687361146e-06 225 510.363636363636 649 4.65105424056071e-07 79 0.906666378539801 -0.871646361360641 -1 4.97806879396714 224 749 754 803 649 79 202 331 852 874 97 712 M17970 GO_COMPLEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_BINDING.html Interacting selectively and non-covalently with any component or product of the complement cascade. 17/27 Gene Ontology MF GO:0001848 4.22134616333197e-05 4.80952386549782e-05 610 656.636363636364 650 3.83766105857509e-06 208 1.25213926009533 -1.46155200054686 -1 5.76977720850657 609 900 556 894 806 517 310 208 915 650 858 713 M17917 GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 143/194 Gene Ontology MF GO:0008234 4.62395781817742e-06 6.58326197842209e-06 640 649.636363636364 652 4.20360685166906e-07 210 1.68986082874862 -1.91371438684805 -1 9.34427255219395 578 652 637 738 639 780 911 678 210 792 531 714 M18814 GO_1_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 19/24 Gene Ontology MF GO:0005545 5.44599760687235e-06 7.49940654061111e-06 765 591.636363636364 653 4.95091917112062e-07 225 1.73830647134809 -1.543913000894 -1 9.50718756159367 764 493 474 282 658 653 733 744 225 564 918 715 M18464 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). 182/229 Gene Ontology MF GO:0016747 6.22759015452958e-07 1.35077307577121e-06 655 650.272727272727 654 5.66144719762583e-08 410 1.28683500031112 -1.43088111567485 -1 8.06031428953316 654 597 774 824 410 710 780 431 629 842 502 716 M18651 GO_LIPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 14/21 Gene Ontology MF GO:0060229 0.000163422855368969 0.000175584556233637 480 646.454545454545 654 1.48577269264113e-05 452 1.44501993402027 -1.0787967462931 -1 5.79131554498228 478 772 587 662 855 526 604 682 839 654 452 717 M17920 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 10/10 Gene Ontology MF GO:0016888 3.25118763447637e-06 4.90865584028785e-06 645 680.909090909091 656 2.95562949012021e-07 308 0.903298237105689 1.10703466213946 1 5.11777233233914 642 833 630 829 603 546 308 747 895 801 656 718 M18753 GO_PROLINE_RICH_REGION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROLINE_RICH_REGION_BINDING.html Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. 25/26 Gene Ontology MF GO:0070064 1.34051666503257e-06 2.36544181935958e-06 665 635.363636363636 656 1.21865225622236e-07 305 1.0174856494629 1.12678950723371 1 6.10898199389439 662 305 656 815 513 646 497 809 748 628 710 719 M18072 GO_RNA_POLYMERASE_I_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_I_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 12/14 Gene Ontology MF GO:0001054 2.27585376911423e-05 2.68225622788462e-05 185 529.454545454545 657 2.06897937516745e-06 61 0.728865504986853 0.787373706034565 1 3.55582192574416 183 831 657 891 779 219 61 125 879 820 379 720 M18453 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 75/107 Gene Ontology MF GO:0004197 8.25041067675389e-06 1.0651792444063e-05 855 613.363636363636 658 7.50040147045135e-07 78 2.27472550581361 -2.62561008346263 -1 12.0710401041283 851 658 372 526 707 873 771 799 78 561 551 721 M18898 GO_CULLIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). 15/16 Gene Ontology MF GO:0097602 0.00259000592149112 0.00266796596595071 385 585.636363636364 659 0.000235732736986213 292 1.03546737885181 1.12108698175325 1 2.84412294083933 300 769 659 822 894 382 383 292 729 754 458 722 M18915 GO_IRON_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_BINDING.html Interacting selectively and non-covalently with iron (Fe) ions. 109/229 Gene Ontology MF GO:0005506 6.38609787150525e-07 1.37256281552322e-06 865 574.090909090909 659 5.8055452047677e-08 140 2.57181929981415 -2.6615873670925 -1 16.0899649059733 861 653 147 675 413 659 746 793 430 140 798 723 M19117 GO_RECEPTOR_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INHIBITOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. 8/14 Gene Ontology MF GO:0030547 4.95538401085111e-06 6.95862435566325e-06 710 624.545454545455 659 4.9553950610096e-07 340 2.00595859941891 -2.29673967978252 -1 11.0406177725877 709 354 917 530 659 645 381 732 701 340 902 724 M18297 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. 75/95 Gene Ontology MF GO:0004722 9.00817299194109e-07 1.75602359589738e-06 720 651.636363636364 660 8.18925152768311e-08 353 1.58374817165083 -1.26839085722485 -1 9.72749513592728 720 660 595 756 459 732 616 896 353 807 574 725 M18666 GO_DEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. 69/77 Gene Ontology MF GO:0004536 6.55417217335146e-07 1.39595807371218e-06 525 634.363636363636 661 5.95834011450096e-08 419 1.29807719895822 1.22665786461341 1 8.11093628056017 524 661 666 749 419 589 537 679 697 657 800 726 M17974 GO_PROTEIN_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any protein phosphatase. 166/199 Gene Ontology MF GO:0019903 7.59326311559571e-07 1.54448131377865e-06 880 644.454545454545 662 6.90296885127184e-08 440 1.74796658467814 -1.63759429813733 -1 10.8401273692873 879 465 485 552 440 843 739 735 559 662 730 727 M18450 GO_LAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMIN_BINDING.html Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. 27/29 Gene Ontology MF GO:0005521 1.21438953087657e-06 2.19159360650382e-06 580 594.727272727273 666 1.10399109201303e-07 230 1.05237685760542 1.35455743658517 1 6.3557010242994 577 620 691 797 500 733 666 244 773 711 230 728 M19023 GO_C_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. 14/20 Gene Ontology MF GO:0016408 1.6645901292579e-05 2.00010569497308e-05 800 549.636363636364 666 1.51327520382805e-06 15 1.49184156177316 -1.9594961990903 -1 7.48096018065598 797 159 476 391 762 688 789 666 15 589 714 729 M17927 GO_DNA_BINDING_BENDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BINDING_BENDING.html The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. 14/24 Gene Ontology MF GO:0008301 4.76191265802586e-05 5.35932679173677e-05 705 621 668 4.32910521183893e-06 413 1.72885929513708 -1.99148404758738 -1 7.87974400763586 684 704 439 413 815 668 705 790 419 588 606 730 M18132 GO_GTPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. 18/20 Gene Ontology MF GO:0005095 0.00016244438018887 0.000174736446210147 825 646.090909090909 668 1.4768761459518e-05 291 1.74397265919588 -1.14284655138601 -1 6.99336513955685 824 693 438 588 854 924 796 426 291 605 668 731 M18478 GO_DOUBLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA. 641/898 Gene Ontology MF GO:0003690 1.03841303705896e-06 1.93837100251006e-06 600 694 669 1.03841352229502e-07 493 1.76322342879796 1.87687056834274 1 10.7491097551128 600 841 862 807 493 657 572 669 608 776 749 732 M18804 GO_RETINOID_X_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOID_X_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a retinoid X receptor. 22/25 Gene Ontology MF GO:0046965 8.72850957591942e-05 9.5107816605537e-05 630 711.454545454545 669 7.93532354468496e-06 557 1.01193175958684 -0.693182749775967 -1 4.34314087044753 778 628 633 669 841 627 557 655 840 747 851 733 M17994 GO_CYCLIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_BINDING.html Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. 18/22 Gene Ontology MF GO:0030332 5.28597883371632e-06 7.35419866636349e-06 765 712.272727272727 671 4.80544684952153e-07 517 1.86795156193597 2.29081397751248 1 10.2331730665864 763 694 517 734 652 910 915 649 671 670 660 734 M18330 GO_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. 76/81 Gene Ontology MF GO:0004527 2.16813463357804e-06 3.49625899027243e-06 450 626.272727272727 672 1.97103342755618e-07 282 1.44344387608788 1.42023341497033 1 8.40504269531919 449 857 748 903 565 366 282 535 717 795 672 735 M18585 GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). 36/44 Gene Ontology MF GO:0016776 1.38005722628464e-05 1.68673660990345e-05 900 705.181818181818 672 1.25460534858386e-06 500 1.62495665695573 2.14719478181241 1 8.27681064796171 900 672 560 649 748 804 866 563 643 500 852 736 M19174 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. 11/12 Gene Ontology MF GO:0016861 0.00025356452453807 0.000269612912167061 440 667.090909090909 672 2.30539776581966e-05 403 0.708542615011943 -0.793643728308839 -1 2.69884457536927 436 832 672 763 864 508 574 403 884 813 589 737 M17926 GO_UBIQUITIN_LIKE_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_BINDING.html Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. 138/151 Gene Ontology MF GO:0032182 2.63988918325408e-07 9.23961214138929e-07 565 635.636363636364 673 2.39989954547958e-08 246 1.34211191053091 -1.09609623361366 -1 8.64277225404341 564 791 738 872 246 621 673 704 345 825 613 738 M18616 GO_METAL_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_CLUSTER_BINDING.html Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. 64/69 Gene Ontology MF GO:0051540 1.06260766448175e-06 1.97158530518301e-06 675 690.090909090909 673 9.6600743429573e-08 423 1.49216713537332 -1.2585133735193 -1 9.08492355176158 589 860 673 828 482 673 626 876 423 769 792 739 M18682 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. 7/13 Gene Ontology MF GO:0050664 1.00488290663939e-05 1.2701939886933e-05 535 679 673 1.00488745072177e-06 522 1.27251405357564 1.63948937330088 1 6.64889679654637 616 522 873 535 735 810 633 720 818 534 673 740 M18845 GO_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. 75/104 Gene Ontology MF GO:0008238 3.00283515128657e-07 9.31080429459327e-07 275 602.909090909091 673 2.72985051013741e-08 271 2.09590456804898 -1.5177262369603 -1 13.4895020153664 673 605 403 731 271 730 685 874 275 716 669 741 M18471 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. 15/22 Gene Ontology MF GO:0016722 4.54512924143197e-06 6.48579474585974e-06 625 692.090909090909 675 4.13194421049996e-07 526 1.48394060199957 -1.59094974285395 -1 8.21587209964924 623 767 526 698 637 754 893 654 725 675 661 742 M18202 GO_AMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. 35/43 Gene Ontology MF GO:0004177 1.43958600907965e-06 2.51584445073565e-06 740 663.363636363636 676 1.30871541007644e-07 518 1.79994242329297 -2.04484221767449 -1 10.7554292314134 738 676 553 819 518 800 670 536 724 733 530 743 M18515 GO_ELECTRON_CARRIER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_CARRIER_ACTIVITY.html Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 114/160 Gene Ontology MF GO:0009055 1.94322299030971e-07 8.40700906161521e-07 695 637.545454545455 677 1.76656651086486e-08 191 1.71283222199498 -1.60982441924681 -1 11.105059164624 695 535 590 729 191 677 596 863 558 691 888 744 M18798 GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. 15/16 Gene Ontology MF GO:0004549 6.04238740476838e-06 8.18646035484748e-06 680 707.545454545455 677 5.49309454589933e-07 511 0.767546035244994 -0.746130911947001 -1 4.1666969890921 677 511 641 600 672 712 613 897 838 853 769 745 M18908 GO_POLY_A_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_RNA_BINDING.html Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. 1309/1614 Gene Ontology MF GO:0044822 5.63628089984056e-06 7.73837080453593e-06 920 667.363636363636 677 5.63629519533965e-07 179 1.12633590497126 1.09297108806089 1 6.14380809592317 179 920 896 919 677 486 397 578 745 920 624 746 M18352 GO_INTERLEUKIN_1_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the interleukin-1 receptor. 27/51 Gene Ontology MF GO:0005149 1.26559028798811e-05 1.56337623810295e-05 720 630.818181818182 678 1.15054324416967e-06 348 2.1133405442001 2.20742155250752 1 10.8388112418323 717 678 348 702 742 641 556 715 692 486 662 747 M18760 GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 624/779 Gene Ontology MF GO:0000988 5.60000780139966e-07 1.26879706209363e-06 670 703.636363636364 679 5.60000921260408e-08 406 1.57910207401277 1.58292850916757 1 9.93680069833366 670 644 881 752 406 665 679 794 500 859 890 748 M18581 GO_IDENTICAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IDENTICAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with an identical protein or proteins. 1258/1724 Gene Ontology MF GO:0042802 1.31547447627788e-07 8.2820001624993e-07 690 497.727272727273 681 1.31547455414917e-08 54 2.01340863843029 2.20117858500401 1 13.0678110566789 687 220 868 200 125 691 743 681 293 54 913 749 M18809 GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING.html Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. 31/34 Gene Ontology MF GO:0001098 6.26367585439505e-06 8.38787897023337e-06 420 598.727272727273 681 5.69426698903335e-07 112 0.856333617831202 0.823204794863793 1 4.63904254750789 416 807 740 770 681 261 112 461 863 857 618 750 M18416 GO_RNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with an RNA polymerase molecule or complex. 44/48 Gene Ontology MF GO:0070063 3.75970010817086e-07 1.03084952520768e-06 680 631.818181818182 682 3.41790977335154e-08 316 1.45250527447922 -2.0470199858307 -1 9.27997769151194 676 865 682 764 316 872 734 409 481 809 342 751 M17984 GO_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. 44/47 Gene Ontology MF GO:0033558 4.22267013070755e-06 6.10542472856413e-06 670 708.090909090909 683 3.83879839609403e-07 460 1.20516349206571 -1.24978024804046 -1 6.70617263355828 915 666 733 460 630 847 800 668 621 766 683 752 M18433 GO_TELOMERASE_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_RNA_BINDING.html Interacting selectively and non-covalently with the telomerase RNA template. 15/16 Gene Ontology MF GO:0070034 4.38849707969736e-05 4.96932757553966e-05 285 576.818181818182 683 3.98962238420618e-06 76 0.712213364024363 0.751831543569496 1 3.2710427913902 281 766 683 826 810 207 76 546 834 852 464 753 M19007 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. 9/10 Gene Ontology MF GO:0046933 0.197758293094706 0.198834235929824 925 691.545454545455 683 0.0217935465557605 288 0.560740669069191 -0.560740669069191 -1 0.419784615248613 439 835 904 517 921 502 288 683 922 921 675 754 M18246 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. 12/14 Gene Ontology MF GO:0004861 5.62681195887278e-06 7.73686644345008e-06 720 670.545454545455 684 5.11529668208525e-07 508 1.32388217939798 -1.17968962236474 -1 7.22148067907812 718 637 558 508 660 777 528 746 788 684 772 755 M18718 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase. 325/400 Gene Ontology MF GO:0044389 1.20793909853346e-06 2.18881374415316e-06 720 667.090909090909 684 1.09812705615355e-07 411 1.6328210267803 -1.365083157056 -1 9.86218449210272 675 719 684 805 497 527 719 890 411 784 627 756 M18303 GO_E_BOX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_E_BOX_BINDING.html Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. 25/40 Gene Ontology MF GO:0070888 1.04243768534409e-05 1.30871252888307e-05 735 660.909090909091 685 9.47675113467918e-07 309 1.70944530389555 -1.55453134554671 -1 8.90819880971411 731 685 503 606 729 592 309 902 713 678 822 757 M19102 GO_ADENYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. 1305/1625 Gene Ontology MF GO:0030554 4.96439795936569e-07 1.21673838579679e-06 720 641.909090909091 685 4.96439906840214e-08 380 1.71040292753677 1.86998884196257 1 10.7962477058136 594 589 913 693 380 716 730 685 420 625 716 758 M18022 GO_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_ACTIVITY.html The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. 7/12 Gene Ontology MF GO:0009881 5.96330138685567e-06 8.11500807283453e-06 855 696.363636363636 686 5.96331738934965e-07 278 2.80749605675661 -2.12009820590546 -1 15.2521748329938 853 524 814 573 686 903 924 787 685 278 633 759 M18375 GO_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOXYGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. 69/89 Gene Ontology MF GO:0051213 1.37916719911154e-06 2.42271956650013e-06 690 640.363636363636 686 1.253789148822e-07 315 1.91346558147787 1.81419322395796 1 11.4672282516089 686 796 451 809 516 919 829 703 315 554 466 760 M18050 GO_ATPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the ATP hydrolysis activity of an ATPase. 21/24 Gene Ontology MF GO:0001671 1.07054350701915e-05 1.33492874559473e-05 810 672.818181818182 691 9.7322610584885e-07 483 1.59903844226632 -1.65804153564961 -1 8.3181513817985 806 691 543 659 734 786 804 483 778 613 504 761 M18992 GO_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. 55/81 Gene Ontology MF GO:0019213 2.84243281386783e-06 4.34410245633346e-06 520 652 691 2.58403316940006e-07 516 1.37179675221449 -1.20694813623488 -1 7.84980325198075 837 742 716 516 596 692 691 518 606 741 517 762 M18629 GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. 11/22 Gene Ontology MF GO:0015106 0.000178072761487837 0.000190880779135454 455 659.363636363636 692 1.61897433378275e-05 266 1.33393933928388 1.40568183103887 1 5.2944889849327 652 452 453 793 858 746 889 692 880 266 572 763 M18801 GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-specific protease. 13/13 Gene Ontology MF GO:1990381 0.000259607019351514 0.000275720558483677 235 555.545454545455 692 2.36034235336371e-05 37 0.7391327957175 -0.80472431646335 -1 2.80768931355063 231 911 692 768 865 225 37 429 801 833 319 764 M19190 GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. 123/150 Gene Ontology MF GO:0001046 3.91285000574033e-06 5.74797043768532e-06 890 666.727272727273 692 3.55714269548017e-07 334 1.87228886673733 2.09910990462793 1 10.4707674156357 889 533 501 334 619 817 857 714 650 692 728 765 M17903 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. 29/30 Gene Ontology MF GO:0031434 4.74347306688114e-05 5.34508428511972e-05 880 674.909090909091 694 4.31234122285043e-06 263 1.1954324122391 1.26029567812642 1 5.44998012540499 880 619 639 718 814 531 263 731 856 694 679 766 M18713 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. 38/43 Gene Ontology MF GO:0044390 9.81446079329076e-07 1.86212767412745e-06 715 693.363636363636 696 8.922241065128e-08 474 1.26412869887471 1.32625222796004 1 7.72999639019768 713 611 619 750 474 696 766 852 693 548 905 767 M18766 GO_SINGLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with single-stranded DNA. 96/108 Gene Ontology MF GO:0003697 7.42305141880782e-06 9.71515511470032e-06 780 584.727272727273 696 6.74825133195448e-07 135 1.10529698289566 1.06376457527273 1 5.91250839733121 135 793 776 849 696 245 266 607 780 814 471 768 M18062 GO_PRENYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRENYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). 16/16 Gene Ontology MF GO:0004659 0.00623151524198042 0.00639058832806871 915 635.090909090909 697 0.000568112396845819 307 0.701597722436868 -0.735258739173269 -1 1.64304393578685 372 828 697 715 907 307 619 337 911 915 378 769 M18348 GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. 316/410 Gene Ontology MF GO:0042578 1.49081396550658e-07 8.2820001624993e-07 795 574.272727272727 697 1.35528551502774e-08 134 1.71895527573802 -1.50575288617802 -1 11.156692930381 791 241 445 723 134 697 704 831 560 334 857 770 M18512 GO_OMEGA_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OMEGA_PEPTIDASE_ACTIVITY.html Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). 14/15 Gene Ontology MF GO:0008242 0.0401566167340766 0.0407296529772632 710 615.090909090909 697 0.00371899011363476 213 1.7313041305798 2.04134490256002 1 2.5683241573913 710 515 462 697 917 735 503 478 213 730 806 771 M18087 GO_HISTONE_DEACETYLASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone deacetylase. 124/158 Gene Ontology MF GO:0042826 1.17295898075762e-06 2.13747672411298e-06 765 665.636363636364 698 1.06632691466965e-07 425 1.54402529022656 1.5825874283864 1 9.34284498897488 762 466 627 425 495 743 656 867 720 698 863 772 M18422 GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME.html The action of a molecule that contributes to the structural integrity of the ribosome. 210/311 Gene Ontology MF GO:0003735 2.81902265166541e-06 4.31969640155694e-06 920 711.090909090909 698 2.56275114899457e-07 360 0.879744298560327 -0.8853156432051 -1 5.03643817095378 360 845 798 918 595 637 601 551 902 917 698 773 M19000 GO_ANGIOTENSIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOTENSIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an angiotensin receptor. 18/21 Gene Ontology MF GO:0031701 7.46969111279463e-06 9.76236858305833e-06 715 645.818181818182 698 6.7906513407846e-07 340 1.8298955128635 2.37913434941006 1 9.78445639730274 712 631 433 603 698 825 842 340 814 460 746 774 M19029 GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 267/338 Gene Ontology MF GO:0003714 2.60350560790164e-06 4.07735454525613e-06 790 701.636363636364 698 2.36682608084144e-07 582 1.47324880507273 1.39958474045769 1 8.47361006398084 790 649 698 650 582 787 760 603 589 762 848 775 M18154 GO_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_BINDING.html Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. 174/227 Gene Ontology MF GO:0003729 7.58582252947421e-06 9.9001412672799e-06 105 616.181818181818 700 6.89622607843987e-07 102 1.08871584848915 1.10971136471302 1 5.81429429991735 102 846 797 917 700 336 252 591 817 909 511 776 M17930 GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. 3/12 Gene Ontology MF GO:0043855 0.0192898261587034 0.0196513774759008 525 686.454545454545 701 0.00194593446743643 380 3.90407464095019 3.90407464095019 1 7.11026383776833 525 785 805 746 906 496 380 701 888 631 688 777 M18557 GO_SUMO_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. 16/17 Gene Ontology MF GO:0019789 1.30861450477233e-05 1.60792526916175e-05 665 700.727272727273 701 1.18965662618221e-06 401 0.801346474317898 -0.920478919293775 -1 4.09947486878916 752 701 661 663 745 586 401 571 885 860 883 778 M18064 GO_LYSINE_ACETYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_ACETYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. 21/21 Gene Ontology MF GO:0070577 0.0157766293325127 0.0160900722993839 385 682.727272727273 703 0.00144462869793726 385 1.01057919414534 0.947022665474972 1 1.9341551422065 385 893 703 874 902 522 506 590 806 720 609 779 M18318 GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. 9/11 Gene Ontology MF GO:0008568 0.000679957116092965 0.000711529303816421 880 731.181818181818 705 6.80165259489199e-05 513 0.764871266578974 -0.69348336404447 -1 2.56939128315768 683 915 844 869 880 559 621 513 876 705 578 780 M19144 GO_RNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. 42/44 Gene Ontology MF GO:0034062 5.60951337439215e-07 1.26879706209363e-06 405 677.545454545455 707 5.09955891335864e-08 387 0.813992172595061 0.866614340258776 1 5.12219947667014 405 875 771 852 387 648 707 428 870 898 612 781 M18084 GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. 7/7 Gene Ontology MF GO:0004523 0.000390408174472161 0.000411800403210362 405 704.363636363636 708 3.90476779780227e-05 402 1.06535283351069 1.06535283351069 1 3.84880810084228 402 917 820 660 874 591 708 555 843 763 615 782 M18734 GO_ENDONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. 113/143 Gene Ontology MF GO:0004519 2.71702276704251e-07 9.30984999064807e-07 710 678.727272727273 708 2.47002100236154e-08 251 1.47020913402448 1.41168304431853 1 9.46251751424142 708 729 644 825 251 685 640 851 492 759 882 783 M17899 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/30 Gene Ontology MF GO:0016675 0.0132796420965303 0.0135734394880465 900 684.181818181818 709 0.00121458951730804 357 0.632430825472884 -0.527177424010174 -1 1.26026753688149 437 690 732 766 900 485 357 667 899 884 709 784 M17958 GO_SIGNAL_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. 39/50 Gene Ontology MF GO:0005048 1.60142384292986e-05 1.9342687985192e-05 730 724.090909090909 709 1.45585045466541e-06 561 1.03532710503691 -0.809494510799605 -1 5.20779119034464 730 612 709 896 759 700 561 650 680 827 841 785 M18991 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 43/50 Gene Ontology MF GO:0016667 1.62432086932072e-06 2.76403772238001e-06 710 702.181818181818 709 1.47665642600273e-07 530 1.3970176642685 -1.29279178067386 -1 8.2868633572042 707 801 701 737 530 761 698 761 546 709 773 786 M18879 GO_PEPTIDOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDOGLYCAN_BINDING.html Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. 7/26 Gene Ontology MF GO:0042834 0.00333268567420352 0.00342155729218228 390 626.818181818182 710 0.000333769430637476 173 1.25058243621325 -1.27127745020161 -1 3.29078764426764 387 783 892 710 897 319 173 777 901 536 520 787 M18225 GO_GDP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_BINDING.html Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. 69/79 Gene Ontology MF GO:0019003 9.53694783913052e-07 1.83586245903263e-06 725 686.727272727273 711 8.66995633943392e-08 466 1.40084394918853 -1.15237081688899 -1 8.57521692364495 722 663 693 743 466 594 750 711 489 867 856 788 M18261 GO_VITAMIN_D_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. 19/22 Gene Ontology MF GO:0042809 1.21285597331871e-06 2.19159360650382e-06 760 710.909090909091 711 1.10259694724046e-07 499 1.33642701490499 1.37373477530106 1 8.07118789481036 711 895 646 759 499 672 594 805 579 757 903 789 M18589 GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY.html Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 14/17 Gene Ontology MF GO:0003906 8.4265376384802e-06 1.08140566360496e-05 805 691.363636363636 711 7.66051810395611e-07 460 1.56361740551677 -1.47454503161526 -1 8.28652243113518 802 770 469 540 711 878 773 856 460 653 693 790 M18827 GO_SNRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_BINDING.html Interacting selectively and non-covalently with a small nuclear RNA (snRNA). 37/42 Gene Ontology MF GO:0017069 4.43932768699271e-05 5.02073290426103e-05 115 554 711 4.03583388151022e-06 112 1.35285211394149 1.330820322829 1 6.20690860976917 112 878 711 830 811 258 139 419 721 866 349 791 M19180 GO_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_BINDING.html Interacting selectively and non-covalently with an RNA molecule or a portion thereof. 1684/2094 Gene Ontology MF GO:0003723 3.37033066538298e-06 5.05549599807448e-06 920 703.272727272727 712 3.37033577700185e-07 316 1.23282639145916 1.19097263238048 1 6.96792308241691 316 919 922 920 614 588 476 628 712 923 718 792 M18010 GO_RETINOIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_BINDING.html Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. 8/31 Gene Ontology MF GO:0001972 1.2611827922849e-07 8.2820001624993e-07 920 559.727272727273 713 1.26118286386109e-08 17 2.98564624586878 -0.833275405157142 -1 19.3780154899223 916 520 812 307 117 833 724 713 17 466 732 793 M17928 GO_RNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. 45/48 Gene Ontology MF GO:0008173 6.6518649806547e-06 8.80562069072342e-06 730 698.090909090909 714 6.04716826650221e-07 440 0.91802422907088 0.85502462282825 1 4.95256209941601 728 667 762 714 689 649 440 570 827 863 770 794 M18714 GO_STEROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a steroid hormone receptor. 101/118 Gene Ontology MF GO:0035258 1.44034817579996e-06 2.51584445073565e-06 875 695.727272727273 714 1.30940828982011e-07 335 1.36133047690298 -1.17111875667021 -1 8.1345337330264 872 602 714 335 519 741 677 921 555 805 912 795 M18764 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES.html Catalysis of the transfer of a phosphate group from one position to another within a single molecule. 10/10 Gene Ontology MF GO:0016868 2.27546271277483e-06 3.63130837064584e-06 760 645.454545454545 714 2.06860460572011e-07 388 1.01467066741904 -0.748290664233159 -1 5.89051152978103 666 714 581 817 570 388 395 728 757 724 760 796 M19090 GO_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. 391/476 Gene Ontology MF GO:0016887 1.2857674142199e-06 2.28911192820653e-06 665 696.818181818182 718 1.1688801506128e-07 453 1.69227801375918 1.84325359176062 1 10.1861622173896 663 788 688 611 509 745 791 864 453 718 835 797 M18775 GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. 60/81 Gene Ontology MF GO:0033613 2.2050003322948e-06 3.54951273003553e-06 720 691.727272727273 719 2.0045477657363e-07 566 1.5913147212508 -1.20857418570504 -1 9.25493253545037 630 797 610 719 566 747 769 595 742 719 715 798 M19066 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. 52/67 Gene Ontology MF GO:0016655 0.214531310709676 0.215464055538848 85 636.363636363636 720 0.0217130468988829 81 1.6524408657196 -1.6524408657196 -1 1.17554927951233 81 874 735 720 919 469 302 613 837 877 573 799 M18103 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. 7/12 Gene Ontology MF GO:0004865 1.2869303791676e-05 1.58549822713448e-05 825 636.090909090909 721 1.28693783208245e-06 83 3.30637007731341 -3.10545353240944 -1 16.9360404681382 830 458 824 401 751 869 822 721 83 531 707 800 M18130 GO_ATPASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_REGULATOR_ACTIVITY.html Modulates the rate of ATP hydrolysis by an ATPase. 40/45 Gene Ontology MF GO:0060590 4.11909216916096e-07 1.1000118971979e-06 725 687.272727272727 721 3.74462994580437e-08 327 1.35779091261279 1.42803529572876 1 8.63398783062629 721 549 605 655 327 821 895 783 765 592 847 801 M18657 GO_NADH_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. 40/44 Gene Ontology MF GO:0003954 0.339132568531304 0.340237234878312 150 679.818181818182 721 0.0369546046645944 150 0.95087414965846 -0.95087414965846 -1 0.475119608085271 150 885 779 721 920 553 350 645 903 895 677 802 M17871 GO_MHC_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the major histocompatibility complex. 23/33 Gene Ontology MF GO:0023023 4.93136954573036e-07 1.21672017060695e-06 725 623.272727272727 722 4.48306422828433e-08 352 2.00024127349801 1.32090946359616 1 12.6257529573367 725 811 383 366 352 849 904 722 798 450 496 803 M17953 GO_MAGNESIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_BINDING.html Interacting selectively and non-covalently with magnesium (Mg) ions. 210/271 Gene Ontology MF GO:0000287 1.58012459266374e-06 2.69877102332957e-06 850 700 722 1.43647793415556e-07 528 1.4463632896997 1.51249391451318 1 8.59559155414279 848 594 722 604 528 799 762 596 615 782 850 804 M17971 GO_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for hormones. 178/307 Gene Ontology MF GO:0051427 7.5647451818791e-07 1.54448131377865e-06 700 701.727272727273 723 6.87704343912137e-08 438 1.4306063117007 1.68771675543083 1 8.87199667840769 697 651 723 554 438 782 906 846 576 806 740 805 M18126 GO_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 194/233 Gene Ontology MF GO:0019207 1.80661409999845e-07 8.37618242795071e-07 845 597.363636363636 723 1.64237658941408e-08 175 2.03018736613815 2.16700352420991 1 13.1660718629135 844 723 345 408 175 888 899 752 351 430 756 806 M18039 GO_ATPASE_ACTIVITY_COUPLED http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. 284/347 Gene Ontology MF GO:0042623 1.71878629213808e-06 2.88232038826785e-06 845 698.181818181818 724 1.56253421360881e-07 446 1.57474949285791 1.6185033434795 1 9.31055497077967 881 843 724 613 541 845 846 446 588 793 560 807 M18505 GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the class II major histocompatibility complex. 23/28 Gene Ontology MF GO:0023026 4.93136954573036e-07 1.21672017060695e-06 730 624.545454545455 724 4.48306422828433e-08 353 2.00024127349801 1.32090946359616 1 12.6257529573367 726 812 384 367 353 850 905 724 799 453 497 808 M19216 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. 11/14 Gene Ontology MF GO:0097153 0.000300768759917551 0.000318704511655754 725 701.909090909091 724 2.73463533464292e-05 174 1.02811955984309 -0.924620778707732 -1 3.83640962492044 724 830 603 795 869 579 174 712 864 665 906 809 M18534 GO_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVITY.html Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 248/313 Gene Ontology MF GO:0016791 1.22655261071312e-07 8.2820001624993e-07 920 628.545454545455 725 1.1150478900876e-08 82 1.65287742440814 -1.43838619922109 -1 10.7278216881961 917 248 527 725 82 855 876 778 549 538 819 810 M18885 GO_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_BINDING.html Interacting selectively and non-covalently with any enzyme. 1910/2452 Gene Ontology MF GO:0019899 1.88056709645189e-07 8.40700906161521e-07 895 673 725 1.88056725559588e-08 203 1.72757873390899 -1.61298595160925 -1 11.200667436722 898 363 893 674 203 885 853 892 443 574 725 811 M18223 GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. 25/32 Gene Ontology MF GO:0015036 1.73824441925645e-05 2.08589330310774e-05 700 730 726 1.58023468497315e-06 656 1.08049764370151 -1.09379819485751 -1 5.39721092328015 698 756 706 656 764 794 726 699 719 735 777 812 M18017 GO_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a substrate. 29/35 Gene Ontology MF GO:0032451 6.5734189547973e-06 8.73933685501108e-06 575 702.545454545455 728 5.97585326883123e-07 509 0.833840556769106 1.08100929014229 1 4.50132734734454 572 809 747 840 687 728 509 542 860 841 593 813 M18055 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY.html Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. 29/39 Gene Ontology MF GO:0061650 2.67675536664991e-05 3.11109680350254e-05 230 640.090909090909 728 2.43344357770381e-06 226 0.929342396769635 0.885214062459109 1 4.46998040526092 226 883 728 835 791 414 450 561 821 870 462 814 M18115 GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING.html Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. 689/977 Gene Ontology MF GO:0001067 6.99539775900535e-07 1.46903352939112e-06 695 720.272727272727 729 6.99539996110785e-08 442 1.77265648857583 1.83827994053902 1 11.0343903338112 691 718 826 801 442 731 650 849 570 729 916 815 M18152 GO_RNA_POLYMERASE_II_CORE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_BINDING.html Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. 21/22 Gene Ontology MF GO:0000993 2.79596026220045e-06 4.29887113730039e-06 730 696.272727272727 729 2.54178528687962e-07 250 0.849575349492719 0.720969870801472 1 4.86562705835651 729 815 718 833 592 464 250 808 866 855 729 816 M18340 GO_LYSOZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOZYME_ACTIVITY.html Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 2/15 Gene Ontology MF GO:0003796 0.000520237908449509 0.000546249803871984 600 676.7 729 5.78175817372166e-05 308 6.28206357304787 -6.28206357304787 -1 21.8726556436834 599 836 846 NA 878 740 914 358 718 570 308 817 M18244 GO_RNA_CAP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING.html Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. 18/18 Gene Ontology MF GO:0000339 6.29209230897822e-05 6.97946373769013e-05 655 725 730 5.72024752060384e-06 462 0.585256620709589 -0.673355995400364 -1 2.59581805025444 655 820 730 668 826 577 462 624 896 871 846 818 M18772 GO_RETINOIC_ACID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. 35/135 Gene Ontology MF GO:0042974 1.04387783153656e-05 1.30874235595628e-05 870 730.090909090909 730 9.48984349695076e-07 519 0.940777374662766 -0.712714627501784 -1 4.90253341291705 867 617 705 519 730 695 657 839 835 826 741 819 M19049 GO_THYROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a thyroid hormone receptor. 38/42 Gene Ontology MF GO:0046966 0.000128790729586064 0.000139184367412308 750 710.818181818182 731 1.1708933615741e-05 529 1.3065205094285 -1.06672261081489 -1 5.3769178967821 748 805 731 670 851 689 529 641 754 772 629 820 M18172 GO_PROTEIN_C_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_C_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 253/295 Gene Ontology MF GO:0008022 2.56259786200587e-07 9.177676063928e-07 740 597.454545454545 732 2.32963469136521e-08 240 1.59331241765944 -1.3828743610263 -1 10.2653905731499 739 368 634 285 240 809 738 850 350 732 827 821 M18547 GO_AMIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BINDING.html Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 225/369 Gene Ontology MF GO:0033218 1.66702120268373e-07 8.2829858135462e-07 910 589.636363636364 732 1.51547393545463e-08 160 1.95342962712579 -1.55531765601395 -1 12.6784159444404 907 372 314 781 160 788 732 768 474 394 796 822 M19186 GO_PHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 78/92 Gene Ontology MF GO:0019208 4.91705523628061e-07 1.21672017060695e-06 735 686.818181818182 734 4.47005121386831e-08 351 1.65564959577666 1.79822948245341 1 10.4506501685273 734 794 576 821 351 783 883 558 537 713 805 823 M18847 GO_FUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 7/11 Gene Ontology MF GO:0008417 0.0412589863618746 0.041801867761373 535 679.454545454545 736 0.00420456589206892 311 1.0720021540083 0.697906086897109 1 1.57736341557595 533 583 887 736 908 423 311 766 867 764 696 824 M18905 GO_3_5_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. 49/52 Gene Ontology MF GO:0008408 5.89636450002398e-07 1.30340688947899e-06 765 707.454545454545 736 5.36033280031632e-08 401 1.3247089008493 -1.29988185581339 -1 8.31945971076242 761 866 736 876 401 669 593 554 699 797 830 825 M19027 GO_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. 749/1167 Gene Ontology MF GO:0043565 1.01426388124158e-06 1.90483704525857e-06 605 718.454545454545 737 1.01426434417092e-07 490 1.71025294584328 1.81346836674688 1 10.4400194165226 602 840 907 808 490 664 586 737 638 834 797 826 M18531 GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. 64/69 Gene Ontology MF GO:0034212 4.36291122916983e-06 6.2793301803005e-06 430 658.818181818182 739 3.96629080133094e-07 233 0.941304491745086 0.816185496813772 1 5.22566702912344 427 739 781 859 633 461 233 663 786 900 765 827 M18239 GO_ANDROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an androgen receptor. 55/64 Gene Ontology MF GO:0050681 8.2487866861806e-06 1.0651792444063e-05 750 692.545454545455 740 7.49892510431251e-07 291 1.25048462804799 1.59773787179941 1 6.6358104081616 750 740 726 291 706 876 918 743 572 811 485 828 M18495 GO_GLYCOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BINDING.html Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. 22/28 Gene Ontology MF GO:0051861 1.20014889991538e-05 1.4885068235192e-05 915 693.818181818182 740 1.09105040640399e-06 281 2.90793772508027 3.10250316365329 1 14.9802475479775 913 814 281 605 740 915 717 393 761 629 864 829 M18307 GO_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids. 189/224 Gene Ontology MF GO:0004518 4.39878007967062e-07 1.13925835267672e-06 685 713.454545454545 742 3.99889178107543e-08 337 1.42575598000443 -1.45923929900807 -1 9.04300260310085 685 923 763 902 337 613 583 742 557 865 878 830 M18570 GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. 69/83 Gene Ontology MF GO:0004843 2.19594119216616e-05 2.59801493157687e-05 745 757.909090909091 743 1.99633010124654e-06 573 1.17043887046816 -1.26085956024811 -1 5.72738078080992 743 736 741 769 775 835 907 672 573 848 738 831 M18005 GO_CORE_PROMOTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. 190/242 Gene Ontology MF GO:0001047 2.32355275250112e-06 3.69528871482106e-06 775 714.727272727273 744 2.11232291504456e-07 518 1.72733111203264 1.83125983127301 1 10.0137697119609 744 724 593 518 572 772 748 812 714 773 892 832 M18042 GO_PROTEASOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_BINDING.html Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. 18/20 Gene Ontology MF GO:0070628 5.35950575119125e-05 5.98089772234386e-05 835 674.363636363636 744 4.87239665513917e-06 129 1.66185851984353 1.68822180755873 1 7.48985214107469 831 896 521 542 821 807 744 640 129 737 750 833 M18482 GO_TELOMERIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERIC_DNA_BINDING.html Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. 35/38 Gene Ontology MF GO:0042162 1.29605789679904e-05 1.59461717262625e-05 855 607.272727272727 744 1.17824139287485e-06 181 1.01221029465112 1.04898871947008 1 5.18209759671951 181 882 751 853 744 334 199 543 855 878 460 834 M18011 GO_DIACYLGLYCEROL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_KINASE_ACTIVITY.html Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. 9/11 Gene Ontology MF GO:0004143 5.2214033538838e-05 5.84089188739544e-05 320 616.181818181818 745 5.2215260416794e-06 316 1.42196727202049 -0.866183204332633 -1 6.42429335797828 895 351 813 320 825 806 745 390 316 497 820 835 M19142 GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 46/47 Gene Ontology MF GO:0016796 7.70575195195375e-07 1.55822331970217e-06 650 700.909090909091 745 7.00523150089358e-08 443 1.14652226464295 -1.11895138576683 -1 7.10552370666518 650 868 745 900 443 629 559 529 752 824 811 836 M19204 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 873/1070 Gene Ontology MF GO:0016772 2.89153283317368e-07 9.30984999064807e-07 740 689.272727272727 745 2.89153320941704e-08 284 1.6889451448647 1.89611775530666 1 10.8703403243503 740 717 923 784 284 819 779 545 484 745 762 837 M18176 GO_INSULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin receptor. 35/46 Gene Ontology MF GO:0005158 3.1969875970739e-07 9.50043708585968e-07 815 669 747 2.90635278332055e-08 285 1.71651743130192 2.12848903402295 1 11.0316786720747 813 747 498 827 285 836 757 651 779 540 626 838 M19077 GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. 52/59 Gene Ontology MF GO:0016278 1.36327799013811e-05 1.6684355799836e-05 540 696.272727272727 747 1.23935130732805e-06 478 0.997983273792737 -1.00574274861666 -1 5.08833026824421 537 864 770 855 747 570 478 582 845 890 521 839 M18596 GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING.html Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. 93/115 Gene Ontology MF GO:0008135 1.78850221079562e-05 2.14064254245487e-05 725 749.545454545455 750 1.62592431880827e-06 560 1.15213184926864 1.53718856442873 1 5.74119760573842 560 856 791 861 766 721 723 750 607 910 700 840 M18903 GO_ZINC_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_BINDING.html Interacting selectively and non-covalently with zinc (Zn) ions. 1019/1372 Gene Ontology MF GO:0008270 2.93369063328455e-07 9.30984999064807e-07 870 715.636363636364 751 2.93369102057895e-08 292 1.62982440230244 -1.44631589930714 -1 10.4898289965172 692 716 895 866 292 678 868 860 498 756 751 841 M19065 GO_TBP_CLASS_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TBP_CLASS_PROTEIN_BINDING.html Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). 20/25 Gene Ontology MF GO:0017025 0.181350566828318 0.182535864650725 435 704.909090909091 752 0.0180263933401686 272 0.860706512568853 0.899080122734839 1 0.678464740219186 431 908 752 854 918 510 272 708 912 845 644 842 M18479 GO_TRANSITION_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_BINDING.html Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 1214/1709 Gene Ontology MF GO:0046914 2.20733593000216e-07 8.64228135305932e-07 865 698.454545454545 753 2.20733614925713e-08 228 1.76341400799324 -1.57840881655399 -1 11.4104459392421 753 715 863 864 228 690 874 834 458 602 802 843 M18454 GO_OLIGOPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOPEPTIDE_BINDING.html Interacting selectively and non-covalently with an oligopeptide. 13/20 Gene Ontology MF GO:1900750 0.0875594818250555 0.0883241934567154 670 732.090909090909 757 0.00829561636268474 523 1.40818589213153 1.44791567370219 1 1.58380329685869 668 829 565 757 913 634 816 869 841 638 523 844 M18003 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 81/105 Gene Ontology MF GO:0016651 0.165882212521489 0.167148488952951 145 650.636363636364 759 0.0163539485195378 144 1.40519246826063 -1.44290322470648 -1 1.16501833003309 144 858 759 806 916 472 390 576 811 837 588 845 M18150 GO_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to an acceptor molecule. 96/114 Gene Ontology MF GO:0016407 3.18087484881657e-06 4.81035738184372e-06 760 685.545454545455 759 2.89170858900072e-07 362 1.04602293660752 0.96696057393953 1 5.93620792180852 447 732 786 904 602 459 362 835 759 896 759 846 M18208 GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. 26/29 Gene Ontology MF GO:0005487 0.00273627181793452 0.00281549572357628 920 562.363636363636 760 0.000249061910995021 48 0.562556412910425 0.524780695110266 1 1.53114215346975 97 816 760 850 898 162 48 320 916 916 403 847 M18057 GO_C2H2_ZINC_FINGER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_C2H2_ZINC_FINGER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. 16/22 Gene Ontology MF GO:0070742 0.000184191125538852 0.000197210428734529 745 752.636363636364 761 1.67460498567492e-05 565 1.06972350740844 1.3234098242063 1 4.22962568062187 745 901 624 761 861 814 721 565 869 808 610 848 M19169 GO_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. 82/97 Gene Ontology MF GO:0008080 1.42804641692415e-06 2.50382331923702e-06 490 674.272727272727 763 1.29822485807915e-07 326 1.06037370522393 0.973619680173365 1 6.33854110669736 490 735 778 848 517 507 326 763 769 891 793 849 M19092 GO_PRE_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MRNA_BINDING.html Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. 36/40 Gene Ontology MF GO:0036002 0.000377141336319053 0.00039826125115292 165 664.727272727273 764 3.42914549436052e-05 164 0.792729827747306 0.712186686733639 1 2.87618273826269 164 881 764 909 872 404 280 639 917 861 621 850 M18465 GO_MOLECULAR_FUNCTION_REGULATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLECULAR_FUNCTION_REGULATOR.html A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators. 1191/1627 Gene Ontology MF GO:0098772 1.06629109934233e-07 8.2820001624993e-07 785 546.909090909091 766 1.06629115050629e-08 51 2.0990845063897 2.29193613290277 1 13.6238811342846 784 221 860 375 76 766 827 881 384 51 791 851 M19020 GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. 90/118 Gene Ontology MF GO:0019783 1.02706894352609e-05 1.29646407625424e-05 720 779 767 9.33703398567143e-07 680 1.1773876472586 -1.31385130169024 -1 6.14068969368073 716 853 767 847 725 864 812 680 704 875 726 852 M18194 GO_RAN_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAN_GTPASE_BINDING.html Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. 33/38 Gene Ontology MF GO:0008536 9.28265184200261e-05 0.000101026740895293 190 646 769 8.43913048742224e-06 189 0.677500365363618 0.768853654602297 1 2.88882620772175 189 886 769 907 843 412 355 473 898 894 480 853 M18769 GO_RIBONUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. 1594/1976 Gene Ontology MF GO:0032553 4.40167999897824e-07 1.13925835267672e-06 700 706.181818181818 770 4.40168087084389e-08 347 1.69052663239864 1.8473032165314 1 10.7223379760717 700 643 882 788 347 808 785 770 455 748 842 854 M18738 GO_TASTE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TASTE_RECEPTOR_ACTIVITY.html Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. 5/40 Gene Ontology MF GO:0008527 0.000161843805303876 0.000174293328788789 785 638.090909090909 771 1.61855593549993e-05 126 3.96358204073568 -5.09596621769838 -1 15.8987110032685 771 784 876 732 914 917 784 126 155 571 389 855 M19051 GO_METALLOAMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOAMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 12/13 Gene Ontology MF GO:0070006 5.10520105876666e-06 7.15812712943914e-06 850 755 771 4.64110264150792e-07 527 1.05439482604654 -0.892064956683871 -1 5.78948080559916 847 712 642 762 648 899 527 780 886 771 831 856 M19013 GO_ENDORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. 49/63 Gene Ontology MF GO:0004521 1.46973230218672e-06 2.55750027725147e-06 755 752.909090909091 772 1.33612116732473e-07 521 1.20723045541386 -1.23563072694558 -1 7.20453147218363 754 800 713 836 521 805 919 687 772 881 594 857 M19098 GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS.html Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 44/44 Gene Ontology MF GO:0016875 0.000107721613331645 0.00011682484826108 805 647 772 9.7933534740129e-06 298 0.787841303061457 -0.879476728597631 -1 3.30626353750272 298 802 772 842 846 401 464 568 802 901 421 858 M18309 GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. 12/15 Gene Ontology MF GO:0008239 0.0808811458316406 0.0816766980857224 810 737.181818181818 774 0.00763793929425054 380 3.43807859142029 -5.19540043773062 -1 3.99153049632172 810 777 380 744 912 893 774 652 723 611 833 859 M18110 GO_RHO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GTPASE_BINDING.html Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. 96/106 Gene Ontology MF GO:0017048 1.42653476277733e-07 8.2820001624993e-07 835 636.818181818182 775 1.296849868434e-08 21 1.34855344755628 -1.15625279499541 -1 8.75263939409379 832 21 631 886 122 877 836 775 525 576 924 860 M18406 GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 928/1422 Gene Ontology MF GO:0001071 9.88545486881027e-07 1.86792644146844e-06 740 756.454545454545 775 9.88545926631284e-08 486 1.6488320257753 -1.51308038422796 -1 10.0800362690829 737 838 855 875 486 775 820 807 684 749 695 861 M18385 GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. 8/8 Gene Ontology MF GO:0003964 0.00199272057087805 0.00206420830436246 890 765.363636363636 777 0.000199450975020922 518 1.01388268739829 1.0702500178275 1 2.90539839969999 563 916 852 890 889 631 518 723 905 777 755 862 M19225 GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a nucleotidyl group to a reactant. 128/136 Gene Ontology MF GO:0016779 9.31029828992403e-07 1.80350432282805e-06 850 767.909090909091 777 8.46391111818324e-08 462 1.1797466158227 -1.34128380847319 -1 7.23150006956461 850 728 777 898 462 768 786 859 702 883 734 863 M19155 GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. 45/52 Gene Ontology MF GO:0019205 7.06367646648816e-07 1.48000840250228e-06 895 642.545454545455 778 6.42152612224327e-08 69 1.44535201944426 1.85590077582312 1 8.99200677304123 892 69 572 814 428 778 832 827 646 421 789 864 M18323 GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. 18/19 Gene Ontology MF GO:0010485 5.71296302121404e-06 7.820411602373e-06 780 748.727272727273 779 5.19361623336199e-07 608 0.734343847044404 0.73396256298876 1 4.00202445344634 779 630 695 608 662 834 688 905 819 829 787 865 M18355 GO_PROTEIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of proteins into, out of or within a cell, or between cells. 102/119 Gene Ontology MF GO:0008565 1.10682000754135e-06 2.03725435651038e-06 780 747 779 1.00620051307536e-07 488 1.16148421960789 1.3821785748337 1 7.05395240712936 562 852 780 913 488 686 672 914 672 899 779 866 M18739 GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. 9/18 Gene Ontology MF GO:0015101 0.00124283156910608 0.00129321663271849 880 788.363636363636 779 0.000124352720035753 617 1.34035437320552 -0.770100874890589 -1 4.13142820293867 899 779 877 748 885 729 658 880 865 617 735 867 M18046 GO_PROTEIN_DIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DIMERIZATION_ACTIVITY.html The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. 1032/1514 Gene Ontology MF GO:0046983 1.33510692915155e-07 8.2820001624993e-07 845 551.090909090909 781 1.33510700936453e-08 50 2.00564558078034 2.12141418026756 1 13.0174257594805 841 223 815 204 129 865 923 879 352 50 781 868 M18250 GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY.html Functions in chain elongation during polypeptide synthesis at the ribosome. 18/20 Gene Ontology MF GO:0003746 0.00050867938328829 0.000534720989941274 800 760.818181818182 782 4.62542761049765e-05 594 0.976844548103889 -0.595872291775072 -1 3.4107960927381 782 764 694 661 876 913 798 798 594 872 617 869 M18692 GO_N_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. 91/116 Gene Ontology MF GO:0016410 7.9676444828339e-07 1.60394411811297e-06 645 736.727272727273 782 7.24331578949325e-08 447 1.05612032133166 1.00374603960728 1 6.53110585795466 643 733 782 906 447 655 483 844 804 893 914 870 M18048 GO_UNFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with an unfolded protein. 101/120 Gene Ontology MF GO:0051082 6.37468659850663e-06 8.51186476447995e-06 855 764.454545454545 783 5.79518642706969e-07 512 1.00800037694546 1.1614327031486 1 5.45381704513794 512 851 784 908 683 720 783 736 851 876 705 871 M18371 GO_TRANSCRIPTION_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COFACTOR_BINDING.html Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. 29/34 Gene Ontology MF GO:0001221 6.96225244087518e-05 7.68795898638205e-05 755 776.545454545455 783 6.32952071115416e-06 553 1.52211973296873 1.43381137464825 1 6.68293317622907 923 755 616 553 830 889 838 754 681 783 920 872 M18177 GO_R_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_R_SMAD_BINDING.html Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. 25/30 Gene Ontology MF GO:0070412 5.58535243803205e-07 1.26879706209363e-06 865 729.727272727273 787 5.07759441458174e-08 386 1.41624052378002 -0.891522309983944 -1 8.9119630674787 908 888 578 717 386 880 787 479 862 677 865 873 M18335 GO_O_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. 18/20 Gene Ontology MF GO:0008171 0.000478018586840723 0.000503062840820989 515 690.363636363636 787 4.34656802624759e-05 278 1.0635372417965 -1.08314110212192 -1 3.74357915746107 514 823 710 831 875 445 278 906 848 787 577 874 M18372 GO_HSP90_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP90_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. 31/38 Gene Ontology MF GO:0051879 4.68628139810046e-06 6.65149617794904e-06 645 750.909090909091 788 4.26026489137184e-07 607 1.42599605786622 1.10527555699373 1 7.87838778527774 788 806 607 892 641 793 642 884 833 673 701 875 M18380 GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. 18/25 Gene Ontology MF GO:0008139 0.0668336820014016 0.0675649039051368 480 752.363636363636 788 0.00626861812495632 479 0.809761003906956 0.569491941950394 1 1.01129822456069 479 902 715 772 911 671 498 814 853 873 788 876 M18722 GO_RNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. 62/69 Gene Ontology MF GO:0003724 0.00123023180535777 0.0012815492538338 775 779.636363636364 789 0.000111901844132267 539 0.84883992849163 -0.921974689241766 -1 2.61997785486772 773 862 789 555 883 912 892 539 766 906 699 877 M18729 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. 204/232 Gene Ontology MF GO:0061659 2.62848394417295e-07 9.23961214138929e-07 860 719.727272727273 790 2.38953114383198e-08 244 1.49295132588967 1.44911301040424 1 9.61413025470377 859 722 757 823 244 858 849 828 421 790 766 878 M17942 GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY.html Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 94/102 Gene Ontology MF GO:0070035 3.72314189000046e-05 4.25765235935696e-05 795 754.272727272727 792 3.38473172691762e-06 601 1.00781891330584 1.09541680771399 1 4.70089327933378 601 795 792 672 803 667 627 923 710 892 815 879 M18511 GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING.html Interacting selectively and non-covalently with any part of the small ribosomal subunit. 19/22 Gene Ontology MF GO:0043024 0.00258832722144446 0.00266796596595071 650 730.636363636364 792 0.000235579767791625 231 0.62401880518052 0.630619709585608 1 1.71399415140734 647 819 712 837 893 490 231 792 913 918 785 880 M18872 GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a macromolecule from one side of the membrane to the other. 22/35 Gene Ontology MF GO:0022884 0.68618940391 0.686932837717053 680 789.363636363636 794 0.1 614 1.82642654583515 0.848620843324 1 0.317869257935974 678 904 660 716 922 750 614 898 794 862 885 881 M18389 GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group (CH3-) to a protein. 74/84 Gene Ontology MF GO:0008276 2.9475028915681e-05 3.40862662303996e-05 800 789.545454545455 795 2.67958398380676e-06 598 0.902110984278781 -0.983054880514077 -1 4.30081515959785 798 861 790 916 795 701 598 781 857 904 684 882 M18668 GO_RRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_BINDING.html Interacting selectively and non-covalently with ribosomal RNA. 66/89 Gene Ontology MF GO:0019843 1.56592756638553e-05 1.90133649321975e-05 800 775.090909090909 799 1.42358064776196e-06 586 1.60786285798567 1.14795347016483 1 8.10049725862088 858 799 690 851 756 818 663 796 586 885 824 883 M18972 GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. 12/12 Gene Ontology MF GO:0004535 0.0202252994856877 0.0205816924281668 705 775.181818181818 799 0.00185578781807419 623 0.885535491983667 -0.463118782508789 -1 1.59378842927246 701 913 676 832 903 623 671 803 785 821 799 884 M17873 GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. 403/483 Gene Ontology MF GO:0019787 3.8835763988401e-07 1.05541899780243e-06 790 719.636363636364 800 3.53052462217568e-08 320 1.46720386035377 1.46030630078187 1 9.35786905986741 800 787 788 820 320 802 843 816 501 828 611 885 M18401 GO_FATTY_ACID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORTER_ACTIVITY.html Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 7/20 Gene Ontology MF GO:0015245 6.20190979167089e-05 6.8876978936345e-05 890 622.181818181818 803 6.20208288505261e-06 14 3.06813639433483 -0.9762615162509 -1 13.627091459948 888 580 854 227 828 803 884 363 14 532 871 886 M17885 GO_OLFACTORY_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_RECEPTOR_ACTIVITY.html Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. 2/849 Gene Ontology MF GO:0004984 1.55067216168316e-06 2.66819567485147e-06 830 731 804 1.72297025598697e-07 354 2.30643175390883 -1.16593126749402 -1 13.7190733126775 828 588 802 NA 550 861 806 784 923 354 814 887 M19161 GO_4_IRON_4_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_IRON_4_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. 41/42 Gene Ontology MF GO:0051539 2.42933400507842e-05 2.84499951925534e-05 810 804.818181818182 804 2.20850984657934e-06 684 1.06167613379426 -0.929847966968873 -1 5.1504793254694 807 873 734 804 784 891 867 684 775 839 795 888 M18435 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a functional group from one position to another within a single molecule. 26/27 Gene Ontology MF GO:0016866 2.55612479161881e-07 9.177676063928e-07 900 765.454545454545 807 2.32375008055326e-08 239 0.897113352698697 -0.676484081704537 -1 5.77991916426905 781 890 725 899 239 681 807 800 846 856 896 889 M17995 GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 6/15 Gene Ontology MF GO:0001608 8.65470536776193e-07 1.70874952132735e-06 870 662.636363636364 811 8.65470873844038e-08 128 3.77082590258205 -3.32855567639654 -1 23.2083813360252 869 523 811 437 465 906 882 820 587 128 861 890 M19113 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_.html Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. 17/19 Gene Ontology MF GO:0042800 0.0140073813132797 0.0143014589320115 905 815.818181818182 811 0.00128157903222764 671 0.5407068010128 -0.530813970747149 -1 1.06439238881306 786 905 743 671 901 811 742 753 914 922 826 891 M17893 GO_HEAT_SHOCK_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAT_SHOCK_PROTEIN_BINDING.html Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. 108/119 Gene Ontology MF GO:0031072 4.73144084696251e-06 6.69502502694236e-06 815 800.272727272727 812 4.30131911153612e-07 643 1.38046329846176 1.26587779044995 1 7.62265353322633 789 849 753 856 643 813 814 802 812 791 881 892 M18035 GO_GUANYLATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYLATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + GMP = ADP + GDP. 14/16 Gene Ontology MF GO:0004385 0.000292108027217529 0.000309882683293911 855 690 813 2.65588017703591e-05 154 1.87987790877675 -1.24907474445202 -1 7.03918972795834 855 768 489 708 890 859 847 154 813 307 900 893 M19150 GO_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOMERASE_ACTIVITY.html Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. 142/174 Gene Ontology MF GO:0016853 5.86155886547684e-07 1.30124638129901e-06 845 789.909090909091 815 5.32869129745354e-08 399 1.4294925019855 -1.30934588924482 -1 8.97862281460137 843 847 758 878 399 791 781 899 774 815 904 894 M18339 GO_EXORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXORIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. 34/34 Gene Ontology MF GO:0004532 5.0267933063988e-07 1.21909632942585e-06 800 773 817 4.56981314088565e-08 360 1.15040306940857 -1.01396185759353 -1 7.26043504023806 882 880 744 843 360 798 636 871 797 817 875 895 M18381 GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. 18/24 Gene Ontology MF GO:0005385 8.19876505453826e-05 8.98654675017004e-05 820 768.545454545455 818 7.4537005589015e-06 596 1.34127493326241 -1.40463437164433 -1 5.79190500566812 878 818 596 818 837 844 782 604 826 606 845 896 M18943 GO_METHYL_CPG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYL_CPG_BINDING.html Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. 16/19 Gene Ontology MF GO:0008327 0.00190060595627823 0.00197099876947372 810 797.545454545455 819 0.00017293180916764 550 0.817709436965056 0.746106337891978 1 2.36075199375961 808 707 674 550 887 922 819 920 882 770 834 897 M18300 GO_AMINOACYL_TRNA_EDITING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOACYL_TRNA_EDITING_ACTIVITY.html The hydrolysis of an incorrectly aminoacylated tRNA. 11/11 Gene Ontology MF GO:0002161 0.0211474003304229 0.0214727449508909 825 801.454545454545 821 0.00194122337689809 609 0.766949813868895 0.501156318416788 1 1.36529222568805 821 914 680 767 905 713 609 837 890 812 868 898 M18105 GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY.html Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. 55/75 Gene Ontology MF GO:0003743 0.00282133464386709 0.00289979222573213 610 817.545454545455 823 0.000256814482077859 610 0.598879679710682 0.618443974615212 1 1.62181721213802 610 872 794 862 895 773 752 782 919 911 823 899 M18925 GO_RETINOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_BINDING.html Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. 8/13 Gene Ontology MF GO:0019841 5.00086685327093e-05 5.60776817041546e-05 780 758 824 5.00097939584718e-06 339 2.02711358635689 1.9012090684818 1 9.19654622270294 870 780 898 816 824 890 776 455 836 339 854 900 M18128 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 36/37 Gene Ontology MF GO:0016893 1.26037052433453e-06 2.24822850286701e-06 880 784.363636363636 826 1.14579204217814e-07 508 0.864064302329136 -0.736604920154477 -1 5.20819260973938 768 879 756 845 508 790 618 826 877 889 872 901 M18036 GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY.html Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. 15/15 Gene Ontology MF GO:0034450 6.47426442491092e-05 7.17292605349843e-05 875 756.909090909091 827 5.88586814589779e-06 394 0.790304930018828 -0.627317594752208 -1 3.49526542163755 732 906 685 873 827 530 394 891 874 851 763 902 M19012 GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. 19/20 Gene Ontology MF GO:0008353 0.00226557234526777 0.00234422043340137 855 731.818181818182 827 0.000206173528511664 439 1.23331244001631 1.07394913635222 1 3.46148947203634 827 897 669 458 891 853 852 686 439 836 642 903 M18731 GO_GUANYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. 337/417 Gene Ontology MF GO:0019001 2.19364491455698e-07 8.64228135305932e-07 845 756 829 1.99422284844348e-08 214 1.53376218982419 1.70413181469677 1 9.92444758825072 829 842 755 893 214 884 808 865 561 822 843 904 M18327 GO_HISTONE_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a histone. 23/27 Gene Ontology MF GO:0032452 1.27762952127812e-05 1.5761410916702e-05 815 822.818181818182 830 1.16148812822996e-06 729 0.823528239370408 1.08283751758892 1 4.22057121202907 812 892 729 839 743 923 862 756 875 830 790 905 M18210 GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY.html Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 13/13 Gene Ontology MF GO:0009982 1.7535268686791e-05 2.10150301771658e-05 925 830.090909090909 836 1.59412804132311e-06 678 0.732533112090215 0.889576769895038 1 3.65655564319424 921 909 678 895 765 824 682 836 904 831 886 906 M18791 GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. 42/46 Gene Ontology MF GO:0018024 8.38333665416434e-05 9.16710422301521e-05 775 832.636363636364 837 7.62150557024459e-06 749 0.7815062205999 -0.628232109970768 -1 3.36750051668091 775 876 775 858 839 829 818 749 906 897 837 907 M17996 GO_RNA_POLYMERASE_III_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_III_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 19/21 Gene Ontology MF GO:0001056 8.02952138462154e-06 1.04496869850568e-05 840 830.545454545455 839 7.29959153707046e-07 701 0.735992884835202 -0.642970127687988 -1 3.91214633567817 839 899 719 838 701 751 802 909 891 880 907 908 M18283 GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES.html Catalysis of the hydrolysis of any acid anhydride. 741/890 Gene Ontology MF GO:0016817 4.71921425925456e-07 1.19140819004131e-06 875 762.545454545455 839 4.71921526144911e-08 371 1.63521605738162 -1.53373878666565 -1 10.3376038784033 873 839 841 870 371 898 917 767 471 794 747 909 M17938 GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 2/14 Gene Ontology MF GO:0099528 0.612579511 0.613908316880694 925 843.2 839.5 0.1 659 0.672430314440352 0.672430314440352 1 0.152053765204424 659 837 807 NA 923 842 831 915 921 914 783 910 M18119 GO_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. 79/90 Gene Ontology MF GO:0008170 8.48390722642877e-06 1.08725801348407e-05 860 805.727272727273 840 7.71267267570814e-07 614 0.897660050081583 -0.991191947120819 -1 4.75497857073029 840 859 787 912 712 832 859 696 847 905 614 911 M18541 GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. 19/25 Gene Ontology MF GO:0015035 0.0209426257052687 0.021288213588194 875 826.818181818182 840 0.00192224404238836 666 0.770092632336488 -0.6207140554981 -1 1.37396742230305 890 821 721 666 904 840 751 872 872 835 923 912 M18587 GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any complex of RNA and protein. 114/123 Gene Ontology MF GO:0043021 8.47669520759009e-05 9.25823448204876e-05 840 838 840 7.70638348722195e-06 758 0.969171422474785 1.02599727313468 1 4.17170496228709 834 850 793 882 840 816 758 868 824 913 840 913 M18164 GO_TRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_BINDING.html Interacting selectively and non-covalently with transfer RNA. 46/47 Gene Ontology MF GO:0000049 1.94733089555411e-05 2.3217209645058e-05 775 812.454545454545 843 1.77031648415915e-06 636 0.823104938526738 -0.948320272988942 -1 4.07064277871491 772 870 773 880 770 905 699 843 887 902 636 914 M19070 GO_RIBOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BINDING.html Interacting selectively and non-covalently with any part of a ribosome. 53/56 Gene Ontology MF GO:0043022 0.000106299869523531 0.000115418424723552 870 783.909090909091 845 9.66409146191974e-06 604 0.965259638614361 1.12776869094323 1 4.05623832782539 661 869 768 910 845 702 646 866 849 903 604 915 M19032 GO_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. 87/110 Gene Ontology MF GO:0004540 4.78787609972712e-07 1.20217323808366e-06 905 750.090909090909 846 4.35261558337856e-08 346 1.47432497317439 -1.56116299975262 -1 9.31432671317596 902 854 707 846 346 867 722 913 468 887 739 916 M19112 GO_TRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. 20/20 Gene Ontology MF GO:0008175 0.000120398583390937 0.000130420036404719 850 806.363636363636 846 1.09459248094905e-05 696 0.815341951109957 -0.679215138208695 -1 3.380074003409 893 696 702 712 848 831 871 706 850 846 915 917 M18785 GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. 126/147 Gene Ontology MF GO:0008757 5.2041314437476e-06 7.25733011796009e-06 925 828.818181818182 848 4.73103977657789e-07 651 1.00063257797545 0.8526161523435 1 5.48789939212899 922 848 795 911 651 886 903 810 781 907 703 918 M18826 GO_HSP70_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP70_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. 31/36 Gene Ontology MF GO:0030544 1.90713243456936e-05 2.27673174359443e-05 755 823.090909090909 858 1.73377178844431e-06 720 1.01958006942327 -0.902937150953701 -1 5.05155236556987 755 887 720 901 769 862 864 788 897 858 753 919 M18627 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. 19/22 Gene Ontology MF GO:0016864 0.0529665217767546 0.0536046726415348 915 849.363636363636 859 0.00493513062341003 704 0.883635282346725 -0.800170021778393 -1 1.19834695006689 864 898 704 834 909 914 912 817 859 796 836 920 M18142 GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 29/30 Gene Ontology MF GO:0016891 3.14218735952474e-06 4.75964118065715e-06 740 824.272727272727 868 2.85653804310561e-07 601 0.852659005075741 -0.779357663471977 -1 4.84305049642309 914 884 737 841 601 920 740 785 868 886 891 921 M18612 GO_TRANSLATION_INITIATION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_BINDING.html Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. 25/32 Gene Ontology MF GO:0031369 4.65978140304302e-05 5.25718927522803e-05 875 827.636363636364 871 4.23625463998383e-06 549 0.874700467587896 -0.747154120151226 -1 3.99448318109761 874 894 749 844 813 838 549 916 871 879 877 922 M19228 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. 52/59 Gene Ontology MF GO:0042054 5.44980923035487e-05 6.0670165407806e-05 910 874.545454545455 876 4.95449476086276e-06 785 0.741340427449596 0.825047084810407 1 3.33624338752652 876 867 785 914 823 874 909 873 907 908 884 923 M18995 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS.html Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). 193/227 Gene Ontology MF GO:0016741 4.8697816506981e-06 6.86973777900007e-06 915 846.272727272727 891 4.42708402743084e-07 644 1.09961400747276 1.07813202788904 1 6.05872823710171 912 924 799 915 644 909 891 854 732 912 817 924 M19189 GO_PROTEIN_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHANNEL_ACTIVITY.html Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel. 10/12 Gene Ontology MF GO:0015266 0.99995805696 0.99995805696 925 874.363636363636 918 0.6 700 0.146029696669808 -0.147436638384839 -1 0 887 918 700 773 924 892 833 924 924 924 919