Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M18659 GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_EXPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). 23/28 Gene Ontology MF GO:0036442 1.52359842047397e-07 1.63698248897436e-06 15 151.272727272727 35 1.38508956908181e-08 14 1.38854275227988 -1.54942411695678 -1 7.73491042967956 14 118 482 226 35 24 27 15 16 653 54 2 M19055 GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_PATTERN_RECOGNITION_RECEPTOR_ACTIVITY.html Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity. 19/40 Gene Ontology MF GO:0008329 1.48569967078515e-07 1.63698248897436e-06 5 91 36 1.35063615556103e-08 3 3.23258784435935 -3.23258784435935 -1 18.0825357622113 3 133 94 139 32 4 6 36 343 181 30 3 M17918 GO_LIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of lipids into, out of or within a cell, or between cells. 97/169 Gene Ontology MF GO:0005319 1.83780522794296e-08 3.69159137091151e-07 40 38.1818181818182 38 1.67073203935941e-09 4 2.89617137751286 -2.85824225056833 -1 18.0115840920986 37 14 39 4 8 38 64 33 67 58 58 4 M18118 GO_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_LIPASE_ACTIVITY.html Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. 10/30 Gene Ontology MF GO:0004806 1.76544901747752e-07 1.65381926038186e-06 15 51 45 1.60495378104612e-08 2 3.5968630591144 -3.51429268660232 -1 20.1111177713723 18 176 72 14 45 8 2 48 69 97 12 5 M18373 GO_AMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BINDING.html Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. 6/11 Gene Ontology MF GO:0043176 3.48306911112073e-06 5.98207408675753e-06 15 219.090909090909 45 3.48307457042947e-07 5 2.40607087545928 2.40607087545928 1 12.1313448368609 45 216 850 36 670 57 15 14 5 493 9 6 M18391 GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE.html The action of a molecule that contributes to the structural integrity of a muscle fiber. 39/67 Gene Ontology MF GO:0008307 4.22705409503121e-07 1.71306929114423e-06 10 59.7272727272727 49 3.84277718837512e-08 6 3.68102495661485 3.66560826650868 1 20.5284453654695 6 73 58 79 199 10 40 7 49 128 8 7 M18157 GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_ACTIVITY.html Combining with a neuropeptide to initiate a change in cell activity. 12/49 Gene Ontology MF GO:0008188 1.36068317737197e-07 1.63698248897436e-06 30 66.1818181818182 54 1.23698478320836e-08 3 4.05243777835156 4.41919637988692 1 22.6830197646311 34 167 54 26 26 39 93 3 115 103 68 8 M18665 GO_WIDE_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WIDE_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. 12/27 Gene Ontology MF GO:0022829 9.91565279088043e-08 1.47775212560863e-06 15 90 55 9.01423021617304e-09 13 3.09112509613128 2.91943561668732 1 17.4219674703016 35 170 129 28 13 97 37 55 13 311 102 9 M18411 GO_CATION_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 53/70 Gene Ontology MF GO:0019829 8.84733994149335e-08 1.36249035098998e-06 55 119 65 8.04303663390070e-09 10 1.87494675943235 -1.9269932706621 -1 10.6092484724319 52 57 294 65 10 51 96 72 135 413 64 10 M18934 GO_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVITY.html Catalysis of the hydrolysis of a lipid or phospholipid. 81/132 Gene Ontology MF GO:0016298 4.99849525944238e-07 1.84352199509307e-06 30 102.363636363636 67 4.54408763192955e-08 14 2.61151886278137 -2.69579596337162 -1 14.4667866586367 62 29 95 132 229 14 67 43 308 121 26 11 M18099 GO_WNT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_PROTEIN_BINDING.html Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling. 30/33 Gene Ontology MF GO:0017147 4.46077132615479e-06 7.23114509713513e-06 10 174.454545454545 68 4.05525488267679e-07 2 2.3284912839077 2.42686457364284 1 11.5523843495568 10 97 172 470 558 2 7 68 407 65 63 12 M18961 GO_CHEMOREPELLENT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOREPELLENT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. 34/41 Gene Ontology MF GO:0045499 3.50801555123493e-07 1.69370198541451e-06 5 131.181818181818 70 3.18910555509687e-08 1 2.6696936964953 2.87868657672794 1 14.885625542486 5 81 77 349 477 1 11 4 355 70 13 13 M19052 GO_GAP_JUNCTION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION_CHANNEL_ACTIVITY.html A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. 6/19 Gene Ontology MF GO:0005243 4.81607301134894e-08 8.72559110291455e-07 70 149.090909090909 70 4.81607311572445e-09 2 3.96094434147486 3.82586712754446 1 23.2192831619403 66 204 909 81 2 30 35 105 15 123 70 14 M18662 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. 19/31 Gene Ontology MF GO:0043395 3.32547831376646e-06 5.76499430003792e-06 10 144.727272727273 71 3.02316667318828e-07 7 2.97951994027639 2.97042237753775 1 15.0825650135353 7 123 62 99 523 40 135 31 457 71 44 15 M17913 GO_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLASE_ACTIVITY.html Catalysis of a ring closure reaction. 16/23 Gene Ontology MF GO:0009975 1.98874617797255e-07 1.65381926038186e-06 30 110.545454545455 73 1.80795123431851e-08 6 2.34113890974358 2.32043302470204 1 13.0701929199275 28 146 174 301 53 17 21 73 287 110 6 16 M18429 GO_RAB_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GTPASE_BINDING.html Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. 122/135 Gene Ontology MF GO:0017137 1.9831659344913e-07 1.65381926038186e-06 55 186.909090909091 73 1.80287828478331e-08 7 1.52245655579372 -1.60233513489269 -1 8.47978910054316 26 7 509 515 51 11 73 168 191 454 51 17 M18984 GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_CYTOSKELETON.html The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 105/144 Gene Ontology MF GO:0005200 4.80924389633663e-09 1.08383935615001e-07 75 106.636363636364 73 4.37203991531793e-10 8 2.77970132852291 3.23141130698103 1 18.7198148948827 177 8 34 72 110 69 172 280 73 48 130 18 M17981 GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 62/157 Gene Ontology MF GO:0022843 1.40837502805039e-12 5.00514817660983e-11 40 122.545454545455 75 1.28034093459207e-13 19 3.05207868492917 3.29084136733298 1 30.4328676722428 121 40 20 179 78 53 240 37 486 19 75 19 M18098 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. 55/67 Gene Ontology MF GO:0004714 4.16150509929878e-07 1.70429971387201e-06 50 105.363636363636 76 3.78318716953316e-08 13 2.49110785557758 2.46068948629939 1 13.8795311036905 99 50 73 49 197 13 121 202 262 76 17 20 M19120 GO_SEMAPHORIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with semaphorin receptors. 27/29 Gene Ontology MF GO:0030215 3.39535641710628e-08 6.40267210082898e-07 5 153.090909090909 78 3.086687699553e-09 1 2.55887643266907 2.75433507239026 1 15.3138220760035 12 100 115 350 439 5 17 1 508 78 59 21 M17874 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. 70/85 Gene Ontology MF GO:0019199 8.24220476413305e-07 2.26337351134104e-06 65 111.181818181818 80 7.49291622912819e-08 3 2.36869847181294 2.34280121437269 1 12.9116822500814 63 35 80 107 319 3 104 130 279 75 28 22 M18041 GO_ANKYRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANKYRIN_BINDING.html Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. 30/49 Gene Ontology MF GO:0030506 2.3559670749469e-07 1.65381926038186e-06 85 125 82 2.1417884793146e-08 9 3.16068715996796 3.46430736723285 1 17.6654518745747 98 82 60 92 82 223 549 9 48 91 41 23 M18056 GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of ATP. 18/21 Gene Ontology MF GO:1990939 2.10718242846213e-07 1.65381926038186e-06 270 159.272727272727 82 1.91562057299113e-08 13 2.06832539552678 2.51362124638995 1 11.5405102638907 82 428 270 318 63 48 13 19 267 207 37 24 M18700 GO_CORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 34/48 Gene Ontology MF GO:0015026 2.14954514869345e-06 4.21694207514384e-06 85 143.181818181818 83 1.95413386267614e-07 7 2.27012574434105 2.43360038727404 1 11.7770346895888 24 83 170 271 459 7 81 83 291 90 16 25 M18124 GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_ACTIVITY.html Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 6/26 Gene Ontology MF GO:0015464 1.79694433309257e-05 2.37255765291873e-05 30 272.090909090909 91 1.79695886379815e-06 23 3.30548282556384 -3.30548282556384 -1 14.7691532935803 27 470 827 313 726 54 23 32 91 345 85 26 M18475 GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_MOVEMENT_OF_SUBSTANCES.html Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance. 99/130 Gene Ontology MF GO:0043492 2.51891040495858e-07 1.65381926038186e-06 55 134.545454545455 94 2.28991881214874e-08 19 1.9524328121113 -1.82496394753913 -1 10.8906932072728 55 19 233 63 94 66 156 108 290 354 42 27 M18166 GO_NITRIC_OXIDE_SYNTHASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_SYNTHASE_BINDING.html Interacting selectively and non-covalently with the enzyme nitric-oxide synthase. 32/45 Gene Ontology MF GO:0050998 9.85642667920775e-07 2.46144277069945e-06 10 127.909090909091 95 8.96039190461895e-08 7 2.94203446514886 3.8100937612997 1 15.9466890166123 95 77 64 110 358 115 323 8 66 184 7 28 M18566 GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. 15/29 Gene Ontology MF GO:0015665 1.84762399348629e-07 1.65381926038186e-06 320 138.454545454545 96 1.67965831695922e-08 13 3.49884150991288 -3.50090328891469 -1 19.5615047356623 319 141 67 13 46 396 218 110 27 96 90 29 M19010 GO_FRIZZLED_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRIZZLED_BINDING.html Interacting selectively and non-covalently with the frizzled (fz) receptor. 32/44 Gene Ontology MF GO:0005109 4.80890969677717e-06 7.70092298062757e-06 45 167.818181818182 99 4.37174564404671e-07 12 2.76572397831668 2.98416928360409 1 13.6589635657296 43 317 99 303 568 12 48 182 146 92 36 30 M18268 GO_ALCOHOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BINDING.html Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group. 85/136 Gene Ontology MF GO:0043178 9.43887017188741e-07 2.42264334411777e-06 100 140.545454545455 100 8.58079474685318e-08 15 2.05753584321442 -1.85611408597985 -1 11.1491636293471 59 27 211 210 343 15 55 191 238 100 97 31 M18989 GO_ALPHA_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_ACTININ_BINDING.html Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. 17/31 Gene Ontology MF GO:0051393 1.74173192576435e-07 1.65381926038186e-06 5 144.545454545455 100 1.5833927851424e-08 2 2.80521321191158 2.82546728329361 1 15.6722869297375 103 131 111 95 100 197 765 2 17 64 5 32 M18444 GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 10/15 Gene Ontology MF GO:0005247 2.46968975363979e-07 1.65381926038186e-06 270 171.363636363636 101 2.24517275534892e-08 1 2.9561728527026 -2.32967940600007 -1 16.5187271984408 269 369 285 51 88 152 101 6 1 543 20 33 M18137 GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic hydroxy compound from one side of the membrane to the other. 51/92 Gene Ontology MF GO:1901618 4.39226070607421e-13 1.62337955696503e-11 235 169.909090909091 102 3.99296427825009e-14 6 3.43342621219732 -3.63851349671005 -1 35.8707201420465 231 51 19 6 72 516 385 179 102 36 272 34 M17888 GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 91/210 Gene Ontology MF GO:0005244 1.31539116687467e-14 5.78772113424853e-13 185 136.909090909091 104 1.19581015170425e-15 16 3.10365514730579 3.39584774781282 1 36.77821561874 184 16 16 94 40 104 326 170 351 22 183 35 M18211 GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY.html Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 169/1410 Gene Ontology MF GO:0004930 7.20936987151466e-19 5.55121480106628e-17 10 191.363636363636 107 6.55397261046784e-20 7 2.74862836493979 3.03116829265368 1 43.2757425054398 107 270 7 384 138 22 676 85 397 8 11 36 M18305 GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 8/20 Gene Ontology MF GO:0005328 2.41882741095527e-07 1.65381926038186e-06 55 170.363636363636 107 2.41882767423798e-08 9 3.24694982871651 2.88356739914854 1 18.1491321226992 53 198 842 151 107 34 9 81 144 216 39 37 M18341 GO_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. 54/106 Gene Ontology MF GO:0005253 2.83017023682068e-07 1.66268825097163e-06 95 101.454545454545 107 2.57288236445951e-08 10 2.56406906691896 -2.56753868242772 -1 14.3144003649872 196 52 91 10 124 91 143 107 38 146 118 38 M19060 GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. 6/11 Gene Ontology MF GO:0008331 1.12788662993977e-05 1.56716879107421e-05 45 278.545454545455 109 1.12789235455779e-06 8 3.41020418674494 3.41020418674494 1 15.8345026106507 44 528 911 188 822 61 109 26 8 346 21 39 M19157 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 24/56 Gene Ontology MF GO:0005245 6.42175333614009e-07 1.95615192380487e-06 75 144.454545454545 109 5.83795928239731e-08 20 3.10253061459916 3.58424841163444 1 17.1199707041417 72 109 78 190 282 89 236 20 349 119 45 40 M19106 GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). 29/59 Gene Ontology MF GO:0015370 1.42753097584119e-07 1.63698248897436e-06 510 211.636363636364 113 1.29775551679137e-08 23 3.74569534880996 -4.42148519039915 -1 20.9617734956975 507 90 43 23 213 525 269 113 64 79 402 41 M19009 GO_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. 91/156 Gene Ontology MF GO:0015293 1.54006925375716e-08 3.16227553438136e-07 415 184.636363636364 115 1.40006296776193e-09 20 2.8526935441158 -3.029622321551 -1 17.9262947244644 413 20 38 82 115 325 353 122 107 80 376 42 M18333 GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. 26/39 Gene Ontology MF GO:0005520 8.97160830586238e-07 2.34959513025491e-06 915 322.636363636364 116 8.15601087680884e-08 29 2.96473299100553 -2.37361435489247 -1 16.1282304220367 913 101 83 44 336 726 407 29 97 116 697 43 M18654 GO_GLUCURONOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. 16/36 Gene Ontology MF GO:0015020 3.79753537645299e-07 1.70429971387201e-06 75 196.363636363636 118 3.45230548360513e-08 5 2.91295544128887 2.68521681681918 1 16.2395149944881 75 437 212 256 386 110 71 5 118 476 14 44 M17881 GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. 122/204 Gene Ontology MF GO:0022853 2.60559436093146e-07 1.66268825097163e-06 140 121 120 2.3687224268436e-08 4 2.22643147415368 -2.36994945903924 -1 12.4220055889915 137 4 76 50 97 120 219 140 221 109 158 45 M19003 GO_GLUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 15/16 Gene Ontology MF GO:0046527 5.20817962889529e-07 1.87024687461194e-06 70 173.363636363636 124 4.73470987441489e-08 21 1.58613070504501 1.70218108944252 1 8.75465363309113 67 155 441 62 237 174 124 21 81 436 109 46 M18684 GO_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. 28/59 Gene Ontology MF GO:0008146 1.15816616516095e-06 2.73694510641615e-06 115 200.454545454545 127 1.0528788862413e-07 10 2.96402937797259 3.25732760423929 1 15.9338811531054 111 98 71 251 373 287 656 10 132 89 127 47 M18412 GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COUPLED_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. 61/83 Gene Ontology MF GO:0042625 9.55592191739734e-08 1.4474871887992e-06 90 140.909090909091 129 8.6872021204259e-09 12 1.89058254859595 -1.98884806223324 -1 10.6500077296541 89 48 255 64 12 129 204 138 206 322 83 48 M18439 GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. 67/148 Gene Ontology MF GO:0004867 8.24680795032825e-17 5.44289324721665e-15 15 174.272727272727 129 7.49709813666203e-18 9 3.15604401735472 3.22967090761814 1 43.6032653450176 13 32 9 129 495 84 275 387 306 18 169 49 M19111 GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORTER_ACTIVITY.html Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 9/27 Gene Ontology MF GO:0005326 1.23910829810053e-07 1.58112794444989e-06 110 201.545454545455 130 1.23910836719306e-08 27 2.94099765331663 2.88356739914854 1 16.4893178991354 106 187 915 60 27 116 130 143 151 281 101 50 M19119 GO_CADHERIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CADHERIN_BINDING.html Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion. 29/34 Gene Ontology MF GO:0045296 7.54481636433498e-08 1.26752914920828e-06 615 301.454545454545 131 6.85892420280146e-09 6 2.2026705572959 -2.03702224005881 -1 12.5405884236125 615 84 117 88 6 536 399 441 36 131 863 51 M19223 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. 78/152 Gene Ontology MF GO:0015081 2.08516180565226e-15 1.0210802163225e-13 25 309.363636363636 133 1.89560164150206e-16 13 3.28230079938813 3.10434803193107 1 41.2968475266362 835 23 13 78 133 812 724 52 187 25 521 52 M18249 GO_PHOSPHATIDYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BINDING.html Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. 13/28 Gene Ontology MF GO:0031210 0.000111510715139017 0.000125653537546893 160 264.545454545455 134 1.01378516044578e-05 10 2.16915945054647 -2.18943891704745 -1 8.14947710829496 159 447 427 114 864 95 46 134 61 553 10 53 M17901 GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_ALPHA_SUBUNIT_BINDING.html Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. 18/23 Gene Ontology MF GO:0001965 6.76247979333841e-07 2.00917406078607e-06 25 134.363636363636 135 6.14771079275196e-08 21 2.22687478995067 2.62005323247323 1 12.2469498748421 21 135 204 43 290 28 47 147 198 293 72 54 M18800 GO_SOLUTE_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). 60/113 Gene Ontology MF GO:0015294 9.00497953275817e-07 2.34959513025491e-06 410 192.181818181818 137 8.1863483805943e-08 29 3.01885489152598 -3.22190372828344 -1 16.42369053497 410 47 55 29 337 352 344 39 84 137 280 55 M18156 GO_MHC_CLASS_II_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_RECEPTOR_ACTIVITY.html Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 7/10 Gene Ontology MF GO:0032395 2.75967568464669e-06 5.02946811166379e-06 80 217 138 2.75967911176713e-07 20 4.31346975827369 4.50238836340425 1 22.1084924498966 143 205 830 80 509 77 138 192 20 98 95 56 M18366 GO_ACTININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTININ_BINDING.html Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin. 30/47 Gene Ontology MF GO:0042805 3.64785439518383e-07 1.69370198541451e-06 695 276.181818181818 138 3.31623181821855e-08 66 2.45387239064648 2.70274219732119 1 13.6776679398955 692 93 138 101 172 921 397 112 85 66 261 57 M18652 GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). 19/33 Gene Ontology MF GO:0015298 1.50834839065994e-06 3.2563409181537e-06 140 183.818181818182 138 1.37122674982187e-07 56 2.38845953999175 -2.39248528303594 -1 12.6539434995498 138 138 196 194 413 127 58 103 282 317 56 58 M18545 GO_INTERMEDIATE_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BINDING.html Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. 24/27 Gene Ontology MF GO:0019215 4.0937886124449e-07 1.70429971387201e-06 70 151.636363636364 139 3.72162670383874e-08 70 3.53884645393931 4.60337188675931 1 19.74099931556 257 104 70 76 192 119 139 238 70 156 247 59 M18754 GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 8/21 Gene Ontology MF GO:0005248 1.30757773791921e-06 2.93252871319746e-06 25 214.545454545455 140 1.30757850731165e-07 11 3.72990067389638 3.72990067389638 1 19.9572354037447 22 197 880 193 449 41 66 11 301 140 60 60 M18777 GO_MICROTUBULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BINDING.html Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. 197/252 Gene Ontology MF GO:0008017 3.43759001736033e-07 1.69370198541451e-06 140 125.727272727273 140 3.12508232227087e-08 4 1.99766345458339 2.44361054779728 1 11.1242543623076 91 266 178 137 159 16 197 46 140 149 4 61 M18284 GO_STEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BINDING.html Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. 40/56 Gene Ontology MF GO:0032934 4.4054009612565e-07 1.74692110295557e-06 215 149 141 4.00491076674405e-08 71 2.23969366156198 -1.89152345782195 -1 12.449718717002 157 71 215 214 206 109 141 128 131 167 100 62 M17876 GO_SYNTAXIN_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_1_BINDING.html Interacting selectively and non-covalently with the SNAP receptor syntaxin-1. 20/27 Gene Ontology MF GO:0017075 4.17736315629269e-07 1.70429971387201e-06 95 185.909090909091 142 3.79760359044655e-08 65 2.08495616916146 -1.67502112244521 -1 11.6073563428792 93 142 364 116 198 65 78 159 93 592 145 63 M19008 GO_PEPTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 43/145 Gene Ontology MF GO:0001653 2.69348296463462e-09 6.54941647190102e-08 95 195.181818181818 147 2.44862087993844e-10 30 3.26290670267915 3.6892016212781 1 22.6760701048324 92 65 30 298 209 147 569 365 242 49 81 64 M18878 GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport. 143/254 Gene Ontology MF GO:0015291 2.82314856811564e-10 7.67232140276133e-09 580 266.363636363636 149 2.56649869861629e-11 7 2.53977794638013 -2.82865619118545 -1 19.9318717297562 563 280 26 7 137 576 580 149 120 39 453 65 M18138 GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT.html The action of a molecule that contributes to the structural integrity of the extracellular matrix. 66/94 Gene Ontology MF GO:0005201 1.58992402216385e-15 8.64170468517292e-14 5 202.272727272727 150 1.4453854746944e-16 1 3.15433346597896 3.08196777262801 1 39.9062603112135 1 36 12 166 738 150 324 371 288 20 119 66 M18794 GO_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_ACTIVITY.html Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. 99/144 Gene Ontology MF GO:0003774 3.19233250765853e-07 1.69329794462269e-06 150 160.090909090909 150 2.902120882623e-08 55 2.22323745927113 2.42616978225332 1 12.387021491134 148 293 173 206 142 55 162 181 143 150 108 67 M17886 GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 14/19 Gene Ontology MF GO:0070008 3.68786690690364e-06 6.27548622832221e-06 275 207.545454545455 152 3.35261189900092e-07 61 1.89987938870551 2.07454956216484 1 9.5288908731503 78 152 281 275 534 83 122 61 272 304 121 68 M18680 GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GLYCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. 104/148 Gene Ontology MF GO:0008194 3.31895765937227e-07 1.69329794462269e-06 155 176.727272727273 153 3.01723469097818e-08 18 2.41756143342257 2.41954574171879 1 13.4746774825144 115 18 93 458 151 43 196 200 326 153 191 69 M18067 GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 71/145 Gene Ontology MF GO:0015103 9.58296499410272e-07 2.43930018031706e-06 155 214.181818181818 154 8.71179015303859e-08 15 2.39752374489394 -2.59095727629806 -1 12.9939085497032 421 33 87 15 346 414 387 152 71 154 276 70 M18646 GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a carboxylic ester bond. 97/170 Gene Ontology MF GO:0052689 1.13377981192307e-07 1.58112794444989e-06 155 189.363636363636 154 1.03070897304811e-08 17 2.28499981316598 -2.32103244191994 -1 12.7986770946959 80 22 182 514 17 153 216 54 364 327 154 71 M18590 GO_NEUROPILIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPILIN_BINDING.html Interacting selectively and non-covalently with a member of the neuropilin family. 15/15 Gene Ontology MF GO:0038191 1.70447643401717e-05 2.26572695680563e-05 50 324 155 1.54953603617853e-06 30 2.78325839069898 2.77278257013413 1 12.4808632240814 47 438 155 739 686 106 97 30 715 132 419 72 M18839 GO_GLYCOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_BINDING.html Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 130/193 Gene Ontology MF GO:0001948 1.35621587746592e-06 3.00413668704452e-06 125 235 155 1.23292428501988e-07 20 2.37917990016096 2.69787996730769 1 12.6853422329038 20 393 52 352 427 125 319 155 530 88 124 73 M19086 GO_EPHRIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_ACTIVITY.html Combining with an ephrin to initiate a change in cell activity. 14/20 Gene Ontology MF GO:0005003 6.98502669959208e-07 2.06203344102974e-06 50 163.090909090909 155 6.35002628849775e-08 43 3.17369488589277 3.70424404891337 1 17.443497432906 48 168 171 268 293 155 132 93 43 308 115 74 M19039 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED_FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. 13/76 Gene Ontology MF GO:0016712 2.5049330173749e-07 1.65381926038186e-06 585 370.545454545455 156 2.27721209326191e-08 74 3.3707990792917 -2.9045466483958 -1 18.8435627161098 582 156 74 87 91 542 661 813 122 83 865 75 M18623 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other. 104/171 Gene Ontology MF GO:0005342 3.18976500752767e-08 6.14029763949077e-07 160 297 160 2.89978641252351e-09 12 2.58123442600257 -2.69643992727026 -1 15.4936115203992 555 12 41 85 160 458 436 720 158 54 588 76 M18701 GO_QUATERNARY_AMMONIUM_GROUP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_BINDING.html Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 22/56 Gene Ontology MF GO:0050997 1.96592297623674e-05 2.56207733433392e-05 70 217.090909090909 160 1.78721867633712e-06 15 2.31606189337955 -2.45772898064333 -1 10.2563984905178 68 423 293 269 699 32 26 63 160 340 15 77 M18537 GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. 245/394 Gene Ontology MF GO:0022804 5.40693844065712e-09 1.1760144805219e-07 260 186.909090909091 162 4.91539859449615e-10 9 2.32302549552878 -2.41123985260638 -1 15.5551651789842 258 254 35 9 140 303 442 157 162 50 246 78 M18143 GO_LYSOPHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPASE_ACTIVITY.html Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. 19/23 Gene Ontology MF GO:0004622 4.42402097501735e-07 1.74692110295557e-06 215 155.181818181818 164 4.02183805877474e-08 22 2.82634414492598 -2.80804892779728 -1 15.7255725437595 49 137 164 215 208 25 22 215 336 243 93 79 M18218 GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TETRAKISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. 11/12 Gene Ontology MF GO:0052743 3.16172516546603e-06 5.56463629122021e-06 125 304.545454545455 165 2.87429973576504e-07 95 1.06425349055706 -1.14779973082766 -1 5.36672998024676 124 368 547 429 515 114 95 137 165 733 123 80 M17947 GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_ANION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 14/21 Gene Ontology MF GO:0008308 1.26627129750316e-07 1.58112794444989e-06 290 214.363636363636 167 1.15115579126086e-08 2 2.36466040372103 -2.07316492622322 -1 13.2468472074827 286 358 376 59 24 272 129 18 2 667 167 81 M18408 GO_ADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_BINDING.html Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. 45/67 Gene Ontology MF GO:0043531 1.07902000178497e-06 2.61018206169821e-06 200 204.636363636364 168 9.80927755459464e-08 70 2.17780124241913 2.45540755867292 1 11.7357685959953 200 70 282 117 365 168 228 141 134 472 74 82 M18470 GO_MICROTUBULE_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_MOTOR_ACTIVITY.html Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 63/81 Gene Ontology MF GO:0003777 5.52448061812851e-07 1.87669856292307e-06 255 166.181818181818 168 5.0222563685423e-08 18 2.23402582820506 2.74377168693297 1 12.3506417607596 64 302 193 392 252 49 82 57 251 168 18 83 M18486 GO_SCAFFOLD_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAFFOLD_PROTEIN_BINDING.html Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. 60/84 Gene Ontology MF GO:0097110 2.66386782869247e-08 5.23705079513158e-07 170 191.181818181818 169 2.42169805540717e-09 40 3.12979627509555 3.76882398810792 1 19.0081069739003 169 301 40 96 278 171 427 50 365 42 164 84 M18554 GO_FILAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMIN_BINDING.html Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. 11/17 Gene Ontology MF GO:0031005 4.77541978543764e-07 1.82334209989437e-06 90 190.636363636364 169 4.34129165637477e-08 26 3.32571795041591 2.96830325981644 1 18.4540984508529 279 169 85 89 222 297 542 174 26 126 88 85 M18817 GO_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_A2_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. 20/33 Gene Ontology MF GO:0004623 5.24073038396858e-07 1.87024687461194e-06 170 193.181818181818 170 4.76430148399062e-08 3 2.72754050273816 -2.37581765680123 -1 15.095486447867 170 136 209 304 238 76 115 22 422 430 3 86 M17957 GO_SULFUR_COMPOUND_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BINDING.html Interacting selectively and non-covalently with a sulfur compound. 231/344 Gene Ontology MF GO:1901681 8.76019630885794e-20 7.35856489944067e-18 30 208.363636363636 171 7.96381482623445e-21 6 2.72974641028479 2.84407590596853 1 45.3013936706653 30 255 6 167 419 165 405 218 440 16 171 87 M19165 GO_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_ACTIVITY.html Catalysis of the hydrolysis of a glycerophospholipid. 69/102 Gene Ontology MF GO:0004620 1.50545988290866e-06 3.2563409181537e-06 175 194.545454545455 171 1.36860083008706e-07 31 2.58500330546929 -2.63266604247193 -1 13.6998904246841 171 42 135 387 412 90 212 78 400 182 31 88 M18106 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a lipoprotein particle receptor. 20/30 Gene Ontology MF GO:0070325 7.26214972655099e-06 1.07708288079183e-05 20 256.363636363636 174 6.60197608986552e-07 18 2.3871423285257 2.48657282992833 1 11.4441874819424 19 633 349 163 616 18 25 257 174 511 55 89 M18805 GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. 42/74 Gene Ontology MF GO:0008028 1.21432461922991e-07 1.58112794444989e-06 25 259 175 1.10393153296043e-08 21 2.98464350087232 -3.23679345452489 -1 16.7348692349391 335 66 48 24 21 588 526 538 175 86 442 90 M18236 GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_TYPE_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 11/14 Gene Ontology MF GO:0004185 1.00832114636224e-05 1.42897045895507e-05 75 228.818181818182 177 9.16659788916323e-07 41 2.21308743282413 2.42776631910179 1 10.3421045710471 74 177 256 280 645 111 169 41 285 374 105 91 M18140 GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). 11/20 Gene Ontology MF GO:0015299 3.8645335255061e-07 1.70429971387201e-06 180 170.090909090909 178 3.51321291304781e-08 32 2.19391434396017 -2.61950411525316 -1 12.2169118932852 127 179 276 278 183 113 32 94 178 373 38 92 M18602 GO_DRUG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_BINDING.html Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 120/211 Gene Ontology MF GO:0008144 2.77389908241846e-07 1.66268825097163e-06 120 264.909090909091 178 2.5217267565175e-08 9 2.21688111412216 2.21741867443906 1 12.3684776293692 343 9 101 178 118 117 564 742 203 145 394 93 M18790 GO_SIALYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. 12/21 Gene Ontology MF GO:0008373 8.85016738882177e-06 1.27974251443996e-05 180 264.181818181818 179 8.0456390831867e-07 104 2.51342214098444 2.88766377543281 1 11.8700751396099 110 178 179 461 631 163 278 209 468 104 125 94 M18012 GO_STEROID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BINDING.html Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. 79/140 Gene Ontology MF GO:0005496 9.06322855027002e-07 2.34959513025491e-06 165 222.272727272727 180 8.23930207636774e-08 30 2.35696655229665 -2.25124781739029 -1 12.8103362074729 165 30 89 397 340 180 354 211 424 124 131 95 M18125 GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_CATION_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. 19/36 Gene Ontology MF GO:0005227 3.8443274176757e-07 1.70429971387201e-06 130 221.181818181818 180 3.49484371767448e-08 10 3.30392501088205 -2.30902600703711 -1 18.42675492968 451 130 127 97 181 215 159 252 10 180 631 96 M17855 GO_BETA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_BINDING.html Interacting selectively and non-covalently with the beta subunit of the catenin complex. 103/129 Gene Ontology MF GO:0008013 2.2500376282222e-07 1.65381926038186e-06 240 214.090909090909 182 2.04548896213051e-08 15 2.02509369708087 2.49612677456061 1 11.298107392121 240 15 191 45 73 182 382 648 130 270 179 97 M18498 GO_CALMODULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_BINDING.html Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. 160/244 Gene Ontology MF GO:0005516 1.49004538109973e-07 1.63698248897436e-06 110 166.636363636364 182 1.35458680183593e-08 11 2.51731599370129 2.65758871822785 1 14.0688784209096 108 274 44 11 49 226 478 193 211 57 182 98 M18802 GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORTER_ACTIVITY.html Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. 49/61 Gene Ontology MF GO:0005548 3.31224385039661e-07 1.69329794462269e-06 60 181.272727272727 182 3.01113122643335e-08 58 2.3905908968636 -2.0924109339883 -1 13.3237199601232 179 60 217 140 150 189 182 298 58 193 328 99 M18397 GO_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). 1045/1327 Gene Ontology MF GO:0032403 2.44602805892913e-07 1.65381926038186e-06 185 260.363636363636 183 2.44602832816656e-08 50 1.97860016514646 2.20372175384553 1 11.0374152133551 183 227 853 170 108 50 460 269 375 73 96 100 M19145 GO_PROTEIN_PHOSPHATASE_2A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_2A_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 2A. 40/44 Gene Ontology MF GO:0051721 4.46921174514732e-07 1.75725602234729e-06 105 210.272727272727 183 4.06292059368183e-08 53 1.98732957186285 2.52478359212088 1 11.0355812783587 102 75 312 124 210 183 225 253 53 629 147 101 M18914 GO_CXCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CXCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a chemokine receptor in the CXCR family. 11/15 Gene Ontology MF GO:0045236 2.2574889467305e-06 4.34566622245621e-06 140 284.818181818182 185 2.05226478473999e-07 107 2.93943500955085 -3.12038531279546 -1 15.2287960642776 140 185 175 584 470 191 107 177 702 269 133 102 M19226 GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. 38/59 Gene Ontology MF GO:0005544 1.18401112243919e-06 2.79088336003523e-06 185 184.636363636364 185 1.07637432696265e-07 72 2.0073913281591 -2.14387333434642 -1 10.756426870641 123 72 195 136 375 185 242 185 96 173 249 103 M19061 GO_GAMMA_CATENIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_CATENIN_BINDING.html Interacting selectively and non-covalently with the gamma subunit of the catenin complex. 15/21 Gene Ontology MF GO:0045295 6.36249629399172e-07 1.95615192380487e-06 280 190.090909090909 187 5.78408921277658e-08 25 3.27973240885254 4.4870919318732 1 18.1010216627835 322 143 102 25 277 279 424 90 42 187 200 104 M17916 GO_PROTEIN_SELF_ASSOCIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SELF_ASSOCIATION.html Interacting selectively and non-covalently with a domain within the same polypeptide. 56/71 Gene Ontology MF GO:0043621 4.01559920567715e-07 1.70429971387201e-06 880 398.636363636364 188 3.65054539875779e-08 32 2.41572137192583 2.83616259493532 1 13.4577890029219 879 49 108 32 188 858 641 732 159 143 596 105 M18544 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. 78/147 Gene Ontology MF GO:0015085 1.50928605453468e-07 1.63698248897436e-06 200 191.363636363636 189 1.37207832552511e-08 34 2.45798095954794 3.04472543726526 1 13.7359273964748 197 296 63 189 34 206 523 116 337 67 77 106 M18656 GO_ION_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. 29/51 Gene Ontology MF GO:0022839 1.70506499293787e-06 3.52337098080143e-06 360 228.363636363636 189 1.55006028583186e-07 33 2.79241969859935 -2.34152490908756 -1 14.7110018509901 358 96 114 33 429 277 189 462 94 130 330 107 M18302 GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7. 24/37 Gene Ontology MF GO:0015175 1.42164096002877e-07 1.63698248897436e-06 605 403.363636363636 194 1.29240095626844e-08 28 2.56855607636344 2.17112380603604 1 14.3564056509504 601 113 142 109 28 680 860 810 154 194 746 108 M18351 GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUGAR_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. 25/37 Gene Ontology MF GO:0051119 7.57487438100864e-06 1.11098157588127e-05 180 230.272727272727 194 6.88627314761052e-07 14 2.86894981561566 -2.3930447875641 -1 13.7280221486402 178 328 137 176 623 207 194 28 14 297 351 109 M18774 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. 15/15 Gene Ontology MF GO:0016307 5.04773879608816e-07 1.84352199509307e-06 170 210.363636363636 196 4.58885450386837e-08 2 2.21493415635146 -2.51935619538637 -1 12.2612497955899 167 160 247 311 234 196 276 111 82 528 2 110 M18686 GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_ACTIVATED_RECEPTOR_ACTIVITY.html Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. 23/25 Gene Ontology MF GO:0042813 1.20885737019405e-05 1.66465605075903e-05 50 269.909090909091 197 1.09896728425651e-06 27 2.01456638194875 2.20590619044964 1 9.27975842630888 46 419 267 484 660 27 44 197 541 136 148 111 M19154 GO_DNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with a DNA polymerase. 14/16 Gene Ontology MF GO:0070182 6.69606642781268e-05 7.79239972203893e-05 85 304.818181818182 197 6.08751840221101e-06 74 1.35164490608168 1.49704935926357 1 5.32872676821903 83 444 561 243 785 86 74 162 197 589 129 112 M18613 GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 18/41 Gene Ontology MF GO:0015125 5.58726121244274e-07 1.88105729843001e-06 100 204 198 5.07932966492725e-08 34 4.09332281088599 -4.4021910836474 -1 22.6728310166639 96 341 69 34 254 403 317 198 139 162 231 113 M19034 GO_LAMININ_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMININ_BINDING.html Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. 32/43 Gene Ontology MF GO:0043236 4.28549975617811e-06 6.99611620973246e-06 555 310.909090909091 199 3.89591645832648e-07 38 2.69219868805528 2.71799379227692 1 13.4031795299215 38 552 157 580 554 199 310 97 561 185 187 114 M18457 GO_GROWTH_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_ACTIVITY.html The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 101/168 Gene Ontology MF GO:0008083 2.61597416297441e-14 1.09870914844925e-12 20 245.090909090909 200 2.37815832997676e-15 17 2.92199151094356 2.98345266463347 1 33.8333208775003 139 17 17 513 57 200 316 346 585 34 472 115 M18663 GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 123/213 Gene Ontology MF GO:0008514 4.27731081932582e-07 1.72007102493193e-06 820 436.363636363636 201 3.88846513721326e-08 3 2.44794553067284 2.32928568069725 1 13.6285665175108 819 3 47 90 201 863 763 907 188 59 860 116 M18980 GO_APOLIPOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOLIPOPROTEIN_BINDING.html Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex. 20/26 Gene Ontology MF GO:0034185 4.44371908381113e-06 7.21616244893055e-06 155 288 201 4.03975278143785e-07 143 2.84637438502765 3.21112643655183 1 14.136868829864 152 340 192 201 557 179 282 679 244 199 143 117 M18165 GO_CALCIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_BINDING.html Interacting selectively and non-covalently with calcium ions (Ca2+). 528/853 Gene Ontology MF GO:0005509 4.74421932024214e-20 4.38365865190373e-18 105 229.363636363636 202 4.74421932024216e-21 5 2.63102183748324 2.76218982524413 1 44.2349692414765 104 241 832 165 66 52 394 235 202 5 227 118 M18222 GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS.html The action of a molecule that contributes to the structural integrity of the lens of an eye. 6/22 Gene Ontology MF GO:0005212 2.89014145736042e-06 5.19550721128605e-06 85 308.090909090909 202 2.89014521618024e-07 23 1.90901054706375 1.86284701766345 1 9.72681253643202 84 384 836 414 517 59 30 44 796 202 23 119 M18678 GO_CHEMOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_ACTIVITY.html The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 23/62 Gene Ontology MF GO:0008009 2.1352626214766e-06 4.20840006910773e-06 100 317.454545454545 202 1.94114972173602e-07 54 3.16184853261688 -3.03381359121294 -1 16.4281250657931 97 334 84 581 456 74 54 853 680 77 202 120 M18363 GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. 16/70 Gene Ontology MF GO:0030594 6.98299652790835e-06 1.04405967504649e-05 165 273.818181818182 203 6.34819881151056e-07 140 2.68088747935408 -3.26203122502473 -1 12.8945712344148 190 346 162 314 612 317 373 203 194 161 140 121 M19200 GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a calcium channel. 35/62 Gene Ontology MF GO:0005246 4.33165767755549e-07 1.7326630710222e-06 915 473.272727272727 203 3.937871391301e-08 79 2.30918853087725 2.73767077823736 1 12.8457485833424 915 79 156 150 203 869 878 875 173 81 827 122 M18703 GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. 37/96 Gene Ontology MF GO:0005249 2.83152928439355e-09 6.70854630456319e-08 370 241.636363636364 204 2.5741175345799e-10 26 3.02303060421009 3.07464670311086 1 20.9742779194801 369 74 31 184 261 192 352 422 543 26 204 123 M18916 GO_STEROID_HYDROXYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HYDROXYLASE_ACTIVITY.html Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. 12/72 Gene Ontology MF GO:0008395 2.84686200361904e-07 1.66268825097163e-06 315 254.454545454545 205 2.58805670182825e-08 8 3.7251409996709 3.73137160585882 1 20.8219886998631 482 154 45 8 311 344 312 795 205 63 80 124 M19213 GO_SEMAPHORIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_ACTIVITY.html Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 9/11 Gene Ontology MF GO:0017154 1.35081379048369e-05 1.83551756236313e-05 145 332.909090909091 206 1.35082200169447e-06 56 2.28430794649292 2.94395968775441 1 10.435864327674 145 458 924 357 679 131 206 56 195 394 117 125 M18186 GO_PHOSPHATE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_BINDING.html Interacting selectively and non-covalently with phosphate. 14/18 Gene Ontology MF GO:0042301 5.39633115967912e-05 6.35996172390753e-05 150 350.363636363636 207 4.90587593603071e-06 60 2.18788175949634 -2.34612808249855 -1 8.84778448992945 146 695 397 548 827 187 149 60 207 499 139 126 M18779 GO_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBULIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules. 288/374 Gene Ontology MF GO:0015631 2.26787097900072e-07 1.65381926038186e-06 135 187.272727272727 207 2.06170110253121e-08 40 1.91321809890664 2.2869937019913 1 10.6708138262134 236 250 234 207 75 96 429 135 223 135 40 127 M18383 GO_RECEPTOR_AGONIST_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_AGONIST_ACTIVITY.html Interacts with receptors such that the proportion of receptors in the active form is increased. 8/18 Gene Ontology MF GO:0048018 4.97807332512314e-05 5.89710224668434e-05 210 291.272727272727 208 4.97818484410224e-06 12 2.67965348841329 -2.87752148706797 -1 10.9345383158622 50 208 851 321 774 105 12 87 373 217 206 128 M18674 GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate into, out of or within a cell, or between cells. 29/47 Gene Ontology MF GO:1901476 1.58669838314359e-06 3.36263602299237e-06 210 218.272727272727 208 1.44245411592157e-07 12 3.12050319608616 -2.61434116512285 -1 16.5074425873853 208 413 98 173 525 184 215 12 33 274 266 129 M18247 GO_ICOSANOID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_RECEPTOR_ACTIVITY.html Combining with an icosanoid to initiate a change in cell activity. 7/14 Gene Ontology MF GO:0004953 4.57220758270253e-08 8.44943961283427e-07 35 239.909090909091 210 4.5722076767754e-09 1 4.4771790159777 -3.31104586917737 -1 26.3135187266428 476 210 838 302 1 348 90 34 35 283 22 130 M18745 GO_ACTIVIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_BINDING.html Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits. 15/16 Gene Ontology MF GO:0048185 2.19847354530753e-05 2.82137438314466e-05 95 251.363636363636 210 1.99863228645126e-06 70 1.61775514506684 1.705502303348 1 7.08124094523369 70 353 393 282 710 92 144 91 210 344 76 131 M18196 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 15/29 Gene Ontology MF GO:0008519 2.24751230058465e-07 1.65381926038186e-06 305 232 211 2.04319320926341e-08 71 2.53976807936735 -2.3683571964837 -1 14.1839192565012 305 147 124 211 71 507 391 293 170 95 238 132 M19035 GO_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glutamate receptor. 43/50 Gene Ontology MF GO:0035254 2.65166523138402e-06 4.85776774351537e-06 350 247.363636363636 212 2.41060766131621e-07 55 1.80662797287006 -1.99488214921248 -1 9.25325600155539 393 62 251 55 497 350 349 196 199 212 157 133 M18868 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. 6/29 Gene Ontology MF GO:0015347 1.08334855171414e-06 2.61026486789024e-06 600 336.909090909091 213 1.08334907985434e-07 9 3.82362294379156 2.21221638974164 1 20.6476123674605 597 213 888 19 377 417 199 194 9 203 590 134 M18556 GO_PROTEOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BINDING.html Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 47/72 Gene Ontology MF GO:0043394 9.82355775717859e-11 2.92805398955904e-09 5 267.272727272727 217 8.93050705237931e-12 4 2.86908445918704 2.95665418937356 1 23.6876424502879 4 303 23 174 800 217 369 312 499 45 194 135 M17878 GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. 27/37 Gene Ontology MF GO:0008376 7.46639379756112e-07 2.12930489782299e-06 220 284.090909090909 218 6.78763302865319e-08 92 2.78015754074328 2.89398694306111 1 15.2358830385607 218 106 158 390 308 140 200 727 496 290 92 136 M18129 GO_CARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. 23/41 Gene Ontology MF GO:0004180 8.46793187382353e-07 2.26793305838056e-06 105 223.454545454545 218 7.6981228483482e-08 99 2.18332753643226 2.55385404040334 1 11.8949429895502 101 115 284 218 329 99 325 277 128 448 134 137 M19168 GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. 8/61 Gene Ontology MF GO:0008391 8.91473203584313e-07 2.34678415986298e-06 335 311.272727272727 219 8.91473561210526e-08 50 2.88601650714086 -1.99891367836751 -1 15.6999596692111 334 196 919 177 352 178 188 479 50 219 332 138 M17960 GO_SYNTAXIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNTAXIN_BINDING.html Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. 91/123 Gene Ontology MF GO:0019905 5.30775800730532e-07 1.87024687461194e-06 180 258 220 4.82523571624057e-08 47 1.80125813522007 -1.54540517635144 -1 9.94974331198589 176 295 371 220 243 47 214 484 201 395 192 139 M18477 GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 34/44 Gene Ontology MF GO:0046915 4.7278948693093e-07 1.81651365381839e-06 60 284.818181818182 220 4.29808716850418e-08 56 1.9926992316554 -2.05150686682643 -1 11.0377160439081 69 555 476 600 220 58 56 175 243 574 107 140 M18485 GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of modified amino acids from one side of a membrane to the other. 12/17 Gene Ontology MF GO:0072349 2.95421643517991e-06 5.27987618202366e-06 310 268.545454545455 220 2.68565491107725e-07 28 1.6176010725712 -1.84114137841831 -1 8.22238621892817 307 181 310 371 506 123 28 124 648 220 136 141 M18552 GO_MODIFIED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a modified amino acid. 73/101 Gene Ontology MF GO:0072341 4.12234120558961e-07 1.70429971387201e-06 225 243.818181818182 221 3.74758361639144e-08 87 2.32642049616766 2.2277141274853 1 12.9582042349587 221 298 189 112 194 87 364 310 450 236 221 142 M18776 GO_NEUREXIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUREXIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. 12/14 Gene Ontology MF GO:0042043 4.1522747801898e-07 1.70429971387201e-06 385 261.272727272727 221 3.77479596717215e-08 35 2.52919369696238 -2.82152245082824 -1 14.0925985128213 384 171 181 35 196 400 584 287 56 221 359 143 M18195 GO_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIPORTER_ACTIVITY.html Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). 48/84 Gene Ontology MF GO:0015297 1.39355633705786e-06 3.0585416993859e-06 225 220.363636363636 223 1.26687019980507e-07 61 1.92527164660599 -2.03782215876353 -1 10.2398127093469 222 61 250 270 405 137 234 126 335 223 161 144 M18617 GO_ENZYME_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_INHIBITOR_ACTIVITY.html Binds to and stops, prevents or reduces the activity of an enzyme. 301/494 Gene Ontology MF GO:0004857 1.19966057583286e-10 3.46401991271738e-09 225 253.636363636364 223 1.09060052354389e-11 24 2.35159930790052 2.55801199374648 1 19.2384777528827 223 249 24 512 112 79 510 398 432 35 216 145 M18509 GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CALCIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 17/22 Gene Ontology MF GO:0099604 6.03676105794992e-07 1.93976750500468e-06 375 273.454545454545 224 5.48796610402464e-08 113 2.46686676057053 3.33818914084144 1 13.6094531458479 371 139 176 113 267 447 637 224 328 134 172 146 M18452 GO_CYCLIC_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 26/43 Gene Ontology MF GO:0030551 4.93888381552764e-07 1.84352199509307e-06 45 215.818181818182 225 4.48989538571029e-08 35 2.00019438821702 2.03879361234818 1 11.0670119268477 41 417 248 477 225 35 43 153 383 249 103 147 M17861 GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. 25/32 Gene Ontology MF GO:0035250 1.45367069672733e-07 1.63698248897436e-06 440 257.545454545455 227 1.32151890252727e-08 29 2.44158895645479 1.98522181148664 1 13.643945748528 437 105 128 91 29 514 500 232 87 227 483 148 M18179 GO_METALLOCARBOXYPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOCARBOXYPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 13/28 Gene Ontology MF GO:0004181 7.8815317619622e-06 1.14866488139638e-05 175 292.090909090909 227 7.16505454345922e-07 121 3.16070503907417 3.98892472549387 1 15.0854430609256 173 443 186 212 628 227 453 285 121 261 224 149 M18345 GO_ION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ion A(out) + ion B(in) = ion A(in) + ion B(out) where ion A and ion B are different types of ion. 30/57 Gene Ontology MF GO:0099516 2.91540989251477e-06 5.22061771450319e-06 230 282.818181818182 227 2.65037614180294e-07 102 2.03928912378065 -2.09656944813788 -1 10.3903390234527 227 102 269 597 505 138 163 131 532 301 146 150 M18573 GO_ACETYLCHOLINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_BINDING.html Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. 5/20 Gene Ontology MF GO:0042166 8.5870630953354e-06 1.24559596547722e-05 60 316.818181818182 227 8.58709627745952e-07 10 3.02481433132077 -3.02481433132077 -1 14.3312105309472 60 529 867 324 853 67 10 23 227 426 99 151 M18191 GO_CATION_CATION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CATION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). 17/28 Gene Ontology MF GO:0015491 1.69262329757511e-06 3.50669041919148e-06 210 264.636363636364 229 1.53874963621568e-07 89 2.19227499495487 -2.08775662887237 -1 11.5415159409139 206 344 229 365 428 195 117 173 436 329 89 152 M18061 GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. 65/89 Gene Ontology MF GO:0005546 1.49591738150469e-07 1.63698248897436e-06 150 369.454545454545 230 1.35992498474678e-08 33 2.41212393911814 2.37137267824277 1 13.4786065379383 827 43 126 146 33 476 605 556 150 230 872 153 M18958 GO_MYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_BINDING.html Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. 80/108 Gene Ontology MF GO:0017022 4.73787652132287e-07 1.81651365381839e-06 785 386.090909090909 231 4.30716140151172e-08 31 2.43159298897039 -1.88792142441745 -1 13.481275609751 783 31 104 181 221 608 410 847 129 231 702 154 M17908 GO_CYTOSKELETAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). 802/1066 Gene Ontology MF GO:0008092 7.84317496735535e-12 2.49899781718495e-10 320 267.818181818182 232 7.84317496738302e-13 3 2.11323135399489 2.4385082159075 1 19.6227475325452 318 232 804 3 56 237 671 267 167 13 178 155 M18707 GO_CHEMOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_BINDING.html Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. 14/31 Gene Ontology MF GO:0019956 4.68662013277886e-05 5.56611439934147e-05 160 334.727272727273 235 4.26065452179631e-06 101 2.32786716949929 2.78094018846435 1 9.54823601296969 156 441 207 480 768 101 235 117 703 306 168 156 M18752 GO_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any chemokine receptor. 36/77 Gene Ontology MF GO:0042379 2.53548151674217e-06 4.67621740812328e-06 75 324.636363636364 235 2.30498585351639e-07 63 2.65352944689817 -2.6117265333235 -1 13.6601080947815 71 489 144 593 491 70 63 520 684 211 235 157 M18102 GO_ARYL_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYL_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. 2/15 Gene Ontology MF GO:0004062 4.3772013178605e-05 5.23903370168795e-05 250 320.3 235.5 4.86365163920027e-06 19 2.45582216987996 -2.45582216987996 -1 10.1388295919085 250 221 823 NA 887 312 31 59 21 580 19 158 M18523 GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SERINE_THREONINE_KINASE_BINDING.html Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity. 9/17 Gene Ontology MF GO:0033612 2.50071541733362e-05 3.16095902273087e-05 240 337.818181818182 237 2.50074355887852e-06 86 2.58113563167732 2.55920134325849 1 11.2083736696194 324 193 866 264 730 204 237 86 184 392 236 159 M18014 GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_5_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. 15/15 Gene Ontology MF GO:0010314 0.000810496831133417 0.000862786949271057 215 343.272727272727 238 7.37086889512006e-05 77 2.82998721902118 3.10023800595507 1 8.35298716467688 211 694 381 238 879 268 108 178 77 607 135 160 M18089 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 7/11 Gene Ontology MF GO:0016813 2.82644020536438e-06 5.11082338504244e-06 235 359.727272727273 240 2.82644380031472e-07 31 2.96111192684069 -2.97468279570953 -1 15.139248058546 233 202 821 31 512 549 700 240 124 171 374 161 M18747 GO_BETA_AMYLOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_BINDING.html Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor. 32/39 Gene Ontology MF GO:0001540 3.51204291653023e-07 1.69370198541451e-06 245 272.454545454545 241 3.1927667974427e-08 85 1.99451992349162 2.30421435181865 1 11.1066599349811 368 85 241 306 163 235 498 499 213 148 241 162 M18060 GO_ACTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BINDING.html Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. 362/479 Gene Ontology MF GO:0003779 4.28888159534611e-09 9.90731648524952e-08 375 255.454545454545 244 3.89898327609751e-10 21 2.20919107166954 2.36700102612499 1 14.9496669648834 373 244 33 128 43 359 680 421 155 21 353 163 M18349 GO_SIGNALING_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_RECEPTOR_ACTIVITY.html Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 541/2031 Gene Ontology MF GO:0038023 4.76520248757764e-32 2.20152354926087e-29 250 304 245 4.76520248757763e-33 2 2.54090841456867 2.74771294431452 1 70.561693234098 249 240 847 126 161 73 632 381 388 2 245 164 M17973 GO_PROTEIN_HETERODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETERODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. 388/584 Gene Ontology MF GO:0046982 3.94626490815681e-07 1.70429971387201e-06 185 338.636363636364 246 3.58751419638266e-08 60 2.00424601858641 2.1261293377672 1 11.1558315229379 477 246 183 737 185 60 677 417 452 147 144 165 M18092 GO_HEPARIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARIN_BINDING.html Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 151/236 Gene Ontology MF GO:0008201 1.64080581430341e-22 2.1658636748805e-20 35 279.272727272727 249 1.49164164936673e-23 3 3.06900719810558 3.12749048970027 1 58.4723933277657 31 392 3 249 608 288 522 243 489 17 230 166 M18290 GO_SH3_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. 125/157 Gene Ontology MF GO:0017124 5.46831205054979e-07 1.87137790174371e-06 910 446.363636363636 250 4.9711940088654e-08 1 1.93262198516751 2.10888994281827 1 10.6790120683395 908 1 224 27 250 786 760 709 232 102 911 167 M18158 GO_EXTRACELLULAR_MATRIX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_BINDING.html Interacting selectively and non-covalently with a component of the extracellular matrix. 75/88 Gene Ontology MF GO:0050840 1.26380769378726e-10 3.53866154260432e-09 5 266.818181818182 252 1.14891608532715e-11 2 3.09425286812579 3.15558486121351 1 25.3042692191648 2 398 25 252 777 158 314 271 514 40 184 168 M19019 GO_NEUROTROPHIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neurotrophin receptor. 19/21 Gene Ontology MF GO:0005165 8.68765500980905e-07 2.30170351933712e-06 255 203 252 7.89787130955333e-08 54 2.40975219967437 3.09242620523216 1 13.1194031855782 252 128 152 54 332 146 270 58 257 319 265 169 M18812 GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. 20/35 Gene Ontology MF GO:0005217 3.01643607481447e-07 1.67902827296902e-06 115 284.818181818182 254 2.74221498945481e-08 111 2.45042157429297 3.24109293769922 1 13.6673343307416 387 119 163 111 134 532 633 360 325 115 254 170 M18923 GO_DOPAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_BINDING.html Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. 3/12 Gene Ontology MF GO:0035240 2.25734358078925e-05 2.88091915559291e-05 80 340.818181818182 254 2.25736651131726e-06 20 3.56784018375126 3.56784018375126 1 15.6541451396313 76 473 897 329 720 62 20 791 98 254 29 171 M19199 GO_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 159/222 Gene Ontology MF GO:0019838 2.32846211474499e-09 5.81486214601182e-08 80 233.090909090909 254 2.11678374291765e-10 29 2.53607933123032 2.80630108571435 1 17.7393055381 77 279 29 254 432 198 455 123 409 51 257 172 M18315 GO_POLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 15/23 Gene Ontology MF GO:0030247 5.43376619333558e-07 1.87137790174371e-06 190 388.545454545455 255 4.93978866856231e-08 173 2.40880793651714 2.27138726394649 1 13.3242295102485 189 583 219 655 247 173 222 642 773 255 316 173 M18614 GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Increases the activity of a peptidase that is involved in the apoptotic process. 22/28 Gene Ontology MF GO:0016505 2.83331440458881e-05 3.52352962293413e-05 260 386.454545454545 256 2.57577354059833e-06 77 1.46696526298657 -1.50045122737256 -1 6.27860103140223 256 634 560 547 734 218 100 77 233 689 203 174 M19227 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. 48/72 Gene Ontology MF GO:0043028 5.46575202998276e-07 1.87137790174371e-06 310 298.454545454545 256 4.96886671628415e-08 84 1.81187829787488 -1.93662307739769 -1 10.0082797489133 306 406 411 240 249 233 256 84 392 620 86 175 M19114 GO_CELL_ADHESION_MOLECULE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MOLECULE_BINDING.html Interacting selectively and non-covalently with a cell adhesion molecule. 218/272 Gene Ontology MF GO:0050839 1.02844407077374e-16 6.33521547596624e-15 260 261.727272727273 257 9.34949155248855e-18 10 2.51018907362062 2.57356077705262 1 34.5081497149944 73 257 10 248 200 257 578 434 443 14 365 176 M19191 GO_HISTONE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 29/49 Gene Ontology MF GO:0035173 5.6506301861093e-07 1.88405289835919e-06 190 266 257 5.13693785223296e-08 65 1.95768737682476 1.98897858535374 1 10.8126845777725 187 414 345 225 257 108 65 464 179 275 407 177 M18981 GO_LIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BINDING.html Interacting selectively and non-covalently with a lipid. 593/886 Gene Ontology MF GO:0008289 2.3434491525671e-07 1.65381926038186e-06 305 295.818181818182 258 2.34344939969606e-08 5 2.08078631902063 -2.12325590335793 -1 11.6103794512785 303 238 903 5 96 258 519 333 323 61 215 178 M17980 GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_GMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. 5/15 Gene Ontology MF GO:0047555 4.3154818941867e-06 7.03263716089685e-06 270 332 259 4.3154902747324e-07 76 2.72311412464869 1.93694644467526 1 13.5517724629809 266 217 808 259 566 162 253 358 76 152 535 179 M18384 GO_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any phosphatase. 212/251 Gene Ontology MF GO:0019902 2.12081004832452e-07 1.65381926038186e-06 395 286 260 1.92800932070146e-08 57 1.84218007216766 -1.76899951664132 -1 10.2724991102667 392 260 237 57 64 440 551 364 145 246 390 180 M18655 GO_ANNEALING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANNEALING_ACTIVITY.html A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide. 15/15 Gene Ontology MF GO:0097617 1.2236146605145e-05 1.67997020254888e-05 120 327.545454545455 260 1.11238315106481e-06 75 2.15560332323646 2.1293637848691 1 9.92507785726412 116 517 461 493 663 75 110 219 260 527 162 181 M18396 GO_CARBON_CARBON_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_CARBON_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 44/54 Gene Ontology MF GO:0016830 4.57571018726972e-07 1.77645219035177e-06 265 328.454545454545 261 4.15973739905221e-08 139 1.83804852008148 -1.9792820179657 -1 10.1939562834737 261 408 490 368 216 254 151 139 564 551 211 182 M18189 GO_CLATHRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_BINDING.html Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. 50/71 Gene Ontology MF GO:0030276 2.03469675936407e-06 4.03446310225836e-06 340 271.545454545455 262 1.84972603743686e-07 59 1.9166375988428 -2.07892930055202 -1 9.97007593138742 203 59 262 309 453 149 336 470 196 210 340 183 M18781 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_PHOSPHATASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. 16/20 Gene Ontology MF GO:0019198 1.43136174433244e-06 3.12666253371908e-06 265 302.181818181818 262 1.301238796004e-07 67 2.17418989093648 3.03360102905717 1 11.5508788912634 262 432 184 138 407 251 528 79 676 300 67 184 M18902 GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_CATION_PROTON_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). 8/13 Gene Ontology MF GO:0005451 2.09782609143555e-07 1.65381926038186e-06 335 307.090909090909 262 2.09782628947492e-08 79 1.95648814186331 -2.41680314723014 -1 10.9134316980838 332 200 894 203 79 333 145 262 516 335 79 185 M18251 GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a monosaccharide from one side of a membrane to the other. 16/25 Gene Ontology MF GO:0015145 3.49496548367587e-06 5.99136940058721e-06 620 306 263 3.17724639623877e-07 12 3.39345428883699 -2.94792391401653 -1 17.1307631326456 619 343 86 172 530 393 263 161 12 160 627 186 M18900 GO_PROTEIN_TYROSINE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_BINDING.html Interacting selectively and non-covalently with protein tyrosine kinase. 66/84 Gene Ontology MF GO:1990782 5.93480359012781e-07 1.92595208502953e-06 460 289.181818181818 263 5.39527744647598e-08 39 2.48958953938804 -2.41205788644633 -1 13.7428298777132 460 46 149 39 263 324 368 827 74 240 391 187 M19121 GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 26/31 Gene Ontology MF GO:0008191 4.55833282988565e-05 5.4347090771798e-05 10 306.090909090909 263 4.14402479989992e-06 8 3.05271069397411 3.08510462083312 1 12.5697142786934 8 416 68 263 854 164 331 506 474 117 166 188 M18578 GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a negatively charged ion from one side of a membrane to the other. 195/337 Gene Ontology MF GO:0008509 9.4938928672612e-10 2.43676583593037e-08 545 321.272727272727 264 8.6308117012347e-11 28 2.44061259221991 -2.55947388314067 -1 17.9634674400605 585 264 28 74 205 544 538 590 117 47 542 189 M18935 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_CELL_ADHESION.html Any protein binding that is involved in cell-cell adhesion. 13/15 Gene Ontology MF GO:0098632 7.01333072258055e-08 1.2227014316348e-06 5 315 264 6.37575540559722e-09 4 2.53329459140361 2.53601222737377 1 14.469881985936 742 162 226 21 4 496 610 611 4 264 325 190 M18527 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_GLYCOSYL_GROUPS.html Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). 214/288 Gene Ontology MF GO:0016757 3.03667694682688e-07 1.68017335261559e-06 250 292.545454545455 265 2.7606157872562e-08 93 1.89069575483079 1.97363091018044 1 10.5319397109276 109 265 305 735 135 93 248 295 371 412 250 191 M18598 GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_ACTIVITY.html Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis. 15/18 Gene Ontology MF GO:0005041 0.000104015717297874 0.00011792702181992 265 350.454545454545 265 9.45642140665157e-06 52 2.20437697515972 2.4816895282684 1 8.34163183552094 57 584 265 377 806 107 52 264 700 435 208 192 M18216 GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of cation from one side of the membrane to the other. 390/681 Gene Ontology MF GO:0008324 2.78082193455216e-14 1.11716498588095e-12 595 355.545454545455 266 2.52801994050199e-15 18 2.44357871433787 -2.33113370054157 -1 28.2674159658575 592 243 18 250 95 737 653 473 266 24 560 193 M18258 GO_GLYCOSAMINOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSAMINOGLYCAN_BINDING.html Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 186/306 Gene Ontology MF GO:0005539 8.22796234308325e-26 1.90065930125223e-23 35 273.181818181818 268 7.47996576643932e-27 1 2.99381952376884 3.18126149348122 1 65.913649119273 32 268 1 347 574 302 524 221 506 12 218 194 M18490 GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 11/12 Gene Ontology MF GO:0015129 5.61874257972599e-07 1.88105729843001e-06 185 322.090909090909 268 5.1079491043079e-08 123 2.84518864563152 2.45213279918607 1 15.7421460802321 558 184 139 182 256 430 320 687 123 268 396 195 M18162 GO_SEROTONIN_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_ACTIVITY.html Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. 3/14 Gene Ontology MF GO:0099589 1.55366192127736e-06 3.32164309585458e-06 460 298.545454545455 269 1.55366300751784e-07 6 4.20968400723631 3.96276021691795 1 22.3107482425304 457 219 831 16 431 364 161 278 6 252 269 196 M18344 GO_NUCLEOTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDASE_ACTIVITY.html Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. 13/15 Gene Ontology MF GO:0008252 1.17084736779373e-05 1.61713448107833e-05 165 384.636363636364 269 1.0644123628446e-06 99 1.5255530789833 1.80337989214973 1 7.0320431054213 162 450 477 745 656 269 174 99 236 701 262 197 M18955 GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol. 9/19 Gene Ontology MF GO:0015166 2.52368523499829e-07 1.65381926038186e-06 685 366.727272727273 270 2.52368552160276e-08 30 4.65498097389621 -4.60026631498589 -1 26.0440519477829 683 189 901 86 120 645 244 270 30 280 586 198 M19021 GO_PHOSPHOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BINDING.html Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. 369/493 Gene Ontology MF GO:0005543 2.60863123112326e-07 1.66268825097163e-06 410 294.090909090909 270 2.3714832185814e-08 20 1.95935030257407 -1.96675719195113 -1 10.9250661939301 406 245 200 20 98 454 644 327 270 205 366 199 M18521 GO_PALMITOYL_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYL_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. 11/16 Gene Ontology MF GO:0016290 4.51744772013325e-07 1.76123278202664e-06 130 279.545454545455 271 4.1067714979451e-08 39 1.72245190448517 -1.28373568675812 -1 9.55552363271795 129 366 326 409 212 172 39 627 147 377 271 200 M18529 GO_WW_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WW_DOMAIN_BINDING.html Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. 29/34 Gene Ontology MF GO:0050699 1.11757639282281e-07 1.58112794444989e-06 645 293.545454545455 271 1.01597859054045e-08 16 2.51325279346131 -1.85347477311353 -1 14.0828273025981 644 95 190 42 16 682 348 377 34 271 530 201 M19159 GO_CYTOKINE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_ACTIVITY.html Functions to control the survival, growth, differentiation and effector function of tissues and cells. 103/239 Gene Ontology MF GO:0005125 2.09962382144236e-15 1.0210802163225e-13 300 243.818181818182 271 1.90874892858396e-16 13 3.0228758173893 -3.27145006335788 -1 38.0283631642191 300 13 14 511 195 298 271 276 548 23 233 202 M18584 GO_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 29/36 Gene Ontology MF GO:0008378 1.87557901319344e-07 1.65381926038186e-06 505 280.909090909091 272 1.70507197553937e-08 47 2.1981191401955 1.85152333816631 1 12.2682720122476 504 92 145 175 47 505 378 326 105 272 541 203 M18691 GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction. 13/13 Gene Ontology MF GO:0043142 8.14159151318802e-05 9.35675442560414e-05 15 301.909090909091 272 7.40172075143883e-06 11 1.71053739408966 1.71053739408966 1 6.62687759979415 11 442 302 527 795 36 14 272 389 263 270 204 M18857 GO_SNARE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_BINDING.html Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 123/160 Gene Ontology MF GO:0000149 6.02561693498847e-07 1.93976750500468e-06 325 278 273 5.47783507759586e-08 29 1.79088762268797 -1.48987849692924 -1 9.86460201155399 141 394 452 322 266 29 176 324 273 521 160 205 M18094 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the epidermal growth factor receptor. 40/47 Gene Ontology MF GO:0005154 6.33338067793219e-07 1.95615192380487e-06 120 282.545454545455 274 5.75762045562955e-08 118 2.07641537041062 -2.14806366428349 -1 11.4390387009997 118 310 225 281 274 244 302 476 250 361 267 206 M18676 GO_VITAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BINDING.html Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 68/91 Gene Ontology MF GO:0019842 3.52358293471747e-07 1.69370198541451e-06 885 458.636363636364 274 3.20325772642247e-08 41 1.89773748731312 1.9345703863511 1 10.5649660594888 883 41 228 255 165 798 805 547 274 234 815 207 M18942 GO_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 11/22 Gene Ontology MF GO:0016502 1.14333969959539e-06 2.71579918361477e-06 300 298.545454545455 274 1.03940026708119e-07 127 2.91000422446061 -2.34154614179099 -1 15.6519279662849 299 183 147 267 371 274 173 512 491 127 440 208 M19172 GO_MACROMOLECULAR_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_BINDING.html Interacting selectively and non-covalently with any macromolecular complex. 1499/1921 Gene Ontology MF GO:0044877 4.13697462837577e-07 1.70429971387201e-06 275 359 274 4.13697539853113e-08 115 1.87016184080071 2.05650891550759 1 10.4057110758775 274 223 920 460 215 203 559 115 451 331 198 209 M19194 GO_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_ACTIVITY.html Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. 147/319 Gene Ontology MF GO:0005261 9.21438259880066e-18 6.54929963176293e-16 10 243.363636363636 275 8.37671145345513e-19 8 2.76495077609402 3.13729765891101 1 40.6589932425352 390 276 8 83 65 232 626 275 382 9 331 210 M18595 GO_RAGE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAGE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products. 5/18 Gene Ontology MF GO:0050786 4.18697007628731e-07 1.70429971387201e-06 220 398.636363636364 276 4.18697086516984e-08 94 2.38340079197086 1.57048126648647 1 13.2769747690171 509 385 869 424 219 270 205 914 220 276 94 211 M18336 GO_TROPOMYOSIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPOMYOSIN_BINDING.html Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. 9/14 Gene Ontology MF GO:0005523 3.87989171076807e-06 6.54740519148698e-06 280 297.090909090909 278 3.87989848488658e-07 16 2.39671318815779 3.0835987722735 1 11.992786192367 298 195 845 262 584 374 279 16 104 278 33 212 M18819 GO_TITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TITIN_BINDING.html Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. 16/28 Gene Ontology MF GO:0031432 3.87566438479053e-06 6.54740519148698e-06 170 341.272727272727 279 3.52333746584737e-07 153 2.30089717688338 1.91533037289635 1 11.5110699208147 166 509 359 245 537 186 170 279 673 477 153 213 M18967 GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a sodium channel. 30/43 Gene Ontology MF GO:0017080 6.38005913121874e-07 1.95615192380487e-06 375 304.454545454545 279 5.80005543768526e-08 17 2.47478726455423 -2.47454014443356 -1 13.6445644988183 374 323 146 144 279 607 520 17 618 189 132 214 M17979 GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 212/397 Gene Ontology MF GO:0015077 2.65788086422751e-12 9.09585895757859e-11 285 367 281 2.41625533111883e-13 21 2.59679049926118 -2.66223452679204 -1 25.2312899265567 623 259 21 84 102 918 841 282 281 37 589 215 M18015 GO_I_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_SMAD_BINDING.html Interacting selectively and non-covalently with an inhibitory SMAD signaling protein. 17/18 Gene Ontology MF GO:0070411 8.82800631157452e-08 1.36249035098998e-06 335 311.545454545455 281 8.02546060528966e-09 9 1.49396508950261 2.05606477099334 1 8.44196615577328 333 153 409 115 9 637 790 66 44 590 281 216 M18331 GO_MACROLIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROLIDE_BINDING.html Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. 16/18 Gene Ontology MF GO:0005527 4.99808660587837e-07 1.84352199509307e-06 165 279.818181818182 282 4.54371612852074e-08 163 1.76608227951934 1.95556031663568 1 9.76503815567914 163 348 352 265 227 282 292 321 171 380 277 217 M18088 GO_ACTIN_FILAMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BINDING.html Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. 133/170 Gene Ontology MF GO:0051015 1.60559678881143e-07 1.65381926038186e-06 575 343.090909090909 283 1.45963355090053e-08 18 2.25310317086945 2.41736554663469 1 12.5765709552908 571 283 81 18 37 531 771 667 59 122 634 218 M18712 GO_FK506_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FK506_BINDING.html Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506. 16/18 Gene Ontology MF GO:0005528 4.99808660587837e-07 1.84352199509307e-06 165 279.363636363636 283 4.54371612852074e-08 164 1.76608227951934 1.95556031663568 1 9.76503815567914 164 349 353 266 228 283 293 305 172 382 278 219 M18109 GO_LIGAND_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. 74/161 Gene Ontology MF GO:0022834 2.42489942041602e-11 7.46869021488134e-10 835 393 284 2.20445401858431e-12 15 2.49020230631355 -2.50753250487403 -1 21.9849786142965 833 26 32 93 104 747 821 639 284 15 729 220 M19108 GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. 10/11 Gene Ontology MF GO:0008195 1.06874907552031e-05 1.50537217344628e-05 285 331.818181818182 284 9.71594788623231e-07 39 1.91386120906682 -1.9943601666076 -1 8.89411790971292 453 462 327 213 648 240 283 284 39 546 155 221 M19229 GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVATOR_ACTIVITY.html Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. 18/21 Gene Ontology MF GO:0030296 2.79122911161673e-05 3.48056099748159e-05 215 351 284 2.53751320518191e-06 145 1.93684429819588 -2.06770472945098 -1 8.31785761397709 213 145 254 335 732 236 192 882 292 296 284 222 M19041 GO_NOTCH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_BINDING.html Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor. 23/30 Gene Ontology MF GO:0005112 4.88074305416513e-06 7.80243353295601e-06 290 320.818181818182 287 4.43704898383885e-07 116 2.52981714843885 -1.55279828655619 -1 12.4751087012674 287 498 213 316 569 239 116 307 219 232 533 223 M18525 GO_RETINAL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_BINDING.html Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. 11/18 Gene Ontology MF GO:0016918 7.51906231233119e-06 1.1063078943621e-05 125 354.363636363636 288 6.83553455524677e-07 111 2.54086690706677 2.29108861966846 1 12.1561594350445 288 362 122 216 621 255 111 711 560 125 527 224 M18978 GO_FATTY_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. 11/20 Gene Ontology MF GO:0015645 1.0847853996427e-06 2.61026486789024e-06 265 325.454545454545 290 9.86169031394261e-08 137 2.03272344267769 -1.42720675728576 -1 10.9501653932015 265 364 277 468 367 290 137 260 240 378 534 225 M17851 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_CYCLIC_AMIDINES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. 22/27 Gene Ontology MF GO:0016814 3.06156135836806e-06 5.41931550791588e-06 350 299.818181818182 296 2.78324147172973e-07 95 2.12730636251337 1.94519422930453 1 10.807772910882 347 126 244 520 511 285 346 95 296 195 333 226 M18944 GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING.html Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 18/25 Gene Ontology MF GO:0090079 2.07082650263024e-07 1.65381926038186e-06 235 429.545454545455 296 1.88256972504911e-08 58 1.15140211696728 -0.849555233308909 -1 6.39926335698628 192 757 643 764 58 234 112 231 716 722 296 227 M18082 GO_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. 161/349 Gene Ontology MF GO:0022836 1.44156658851541e-21 1.48000836420915e-19 695 391.272727272727 297 1.31051508046855e-22 5 2.87596731092911 3.11524243055859 1 52.462975191096 691 269 5 75 59 453 830 906 297 7 712 228 M18097 GO_SERINE_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 124/379 Gene Ontology MF GO:0017171 3.63074308343518e-10 9.58516174026888e-09 320 303.181818181818 297 3.30067553094033e-11 5 2.80188705794483 -3.18555281574636 -1 21.7320333321647 316 5 27 297 85 558 494 792 417 55 289 229 M18565 GO_INTEGRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_BINDING.html Interacting selectively and non-covalently with an integrin. 137/163 Gene Ontology MF GO:0005178 4.16240095540423e-07 1.70429971387201e-06 475 305.090909090909 298 3.78400158448261e-08 29 2.43417690106758 2.35173649352972 1 13.5610366045343 29 478 46 253 444 211 475 472 598 52 298 230 M18575 GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 327/580 Gene Ontology MF GO:0022890 1.30355218519461e-14 5.78772113424853e-13 780 433.363636363636 298 1.18504744108602e-15 15 2.48416841509465 -2.33992002743619 -1 29.4259958684156 806 248 15 171 129 778 879 636 298 27 780 231 M18123 GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. 37/60 Gene Ontology MF GO:0015179 7.1950361485668e-07 2.09722820229518e-06 160 368.727272727273 299 6.54094409243962e-08 76 2.30100124553576 2.06222240027615 1 12.6149347926831 402 76 160 186 299 418 489 893 192 159 782 232 M19171 GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_O_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any O-glycosyl bond. 69/105 Gene Ontology MF GO:0004553 7.06624989030571e-07 2.07695764029584e-06 230 347 299 6.42386559994362e-08 169 1.88589791591108 -1.65142401425506 -1 10.336667933515 228 299 437 650 294 319 367 169 256 624 174 233 M19028 GO_GTP_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. 19/22 Gene Ontology MF GO:0030742 7.28233841116297e-07 2.109366988061e-06 45 357.909090909091 301 6.62030983793648e-08 3 1.12807134227117 -1.12807134227117 -1 6.15284616588277 17 576 625 865 301 6 3 42 824 635 43 234 M19182 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 37/89 Gene Ontology MF GO:0004869 5.44878096074315e-06 8.51890627364918e-06 210 339 301 4.95344950535199e-07 49 1.95201909125758 -2.06209930284649 -1 9.54066943076784 207 316 266 325 583 301 254 290 731 407 49 235 M17955 GO_DNA_SECONDARY_STRUCTURE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SECONDARY_STRUCTURE_BINDING.html Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions. 23/27 Gene Ontology MF GO:0000217 5.98475000365548e-06 9.11022900062218e-06 25 296.909090909091 302 5.44069662207069e-07 20 1.47891243374346 1.50832424066336 1 7.17276756163914 25 567 552 436 597 20 34 40 624 302 69 236 M18079 GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of metal ions from one side of a membrane to the other. 247/461 Gene Ontology MF GO:0046873 6.46982778921566e-22 7.47265109654409e-20 715 402.272727272727 302 5.88166162655968e-23 4 2.75019934802866 2.95250562748814 1 50.9578555905568 715 253 4 77 145 470 886 902 302 10 661 237 M19184 GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. 75/108 Gene Ontology MF GO:0000980 4.10494659797686e-06 6.82188967001909e-06 390 298.727272727273 302 3.7317765975949e-07 37 1.69655705198858 1.77356440544919 1 8.44339602227021 302 37 335 244 546 219 389 104 497 387 226 238 M18100 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_HEXOSYL_GROUPS.html Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). 153/208 Gene Ontology MF GO:0016758 2.08976870138387e-07 1.65381926038186e-06 345 306.454545454545 304 1.89978990899087e-08 60 2.06849715040605 2.08046146902083 1 11.5414733043789 126 284 239 734 60 188 304 342 344 427 323 239 M18704 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 31/38 Gene Ontology MF GO:0097472 1.29183247758086e-06 2.9184675043636e-06 135 280.818181818182 304 1.17439385103736e-07 45 2.11580196665476 2.52364515213703 1 11.3005637775625 134 554 378 526 394 78 51 45 304 514 111 240 M18711 GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. 55/83 Gene Ontology MF GO:0035004 9.53148055681721e-07 2.4328972470992e-06 460 306.363636363636 304 8.66498607847749e-08 53 2.26289833241727 -2.2116875007064 -1 12.2635965558795 456 53 96 145 345 304 351 894 176 157 393 241 M18836 GO_CARBONATE_DEHYDRATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBONATE_DEHYDRATASE_ACTIVITY.html Catalysis of the reaction: H2CO3 = CO2 + H2O. 8/14 Gene Ontology MF GO:0004089 6.67531596976583e-07 1.99611390163872e-06 545 342.272727272727 304 6.67531797495962e-08 51 2.80145637503911 -3.71351995236215 -1 15.4292566146954 543 190 886 208 304 372 153 516 51 141 401 242 M18052 GO_VIRUS_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRUS_RECEPTOR_ACTIVITY.html Combining with a virus component and mediating entry of the virus into the cell. 70/110 Gene Ontology MF GO:0001618 6.34795813196386e-07 1.95615192380487e-06 880 439.727272727273 306 5.77087269420634e-08 38 2.45527071324071 1.96693905328042 1 13.5365140614275 877 614 185 38 276 808 756 306 519 165 293 243 M18321 GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate. 47/81 Gene Ontology MF GO:0004715 1.63984354985274e-06 3.42808923091388e-06 225 346.727272727273 306 1.49076797469657e-07 149 2.180134673363 -2.18272304635298 -1 11.4981039864019 452 306 223 149 425 615 481 266 224 196 477 244 M18924 GO_SH3_SH2_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH3_SH2_ADAPTOR_ACTIVITY.html Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). 45/69 Gene Ontology MF GO:0005070 2.24113683871236e-06 4.34566622245621e-06 310 267.272727272727 307 2.03739920159863e-07 85 1.76542350280304 -1.72917946929026 -1 9.1237543961943 100 404 347 307 465 85 92 391 263 309 177 245 M18192 GO_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASE_BINDING.html Interacting selectively and non-covalently with any protease or peptidase. 121/192 Gene Ontology MF GO:0002020 3.51145422248362e-07 1.69370198541451e-06 790 427.818181818182 309 3.19223162086584e-08 106 2.30675443428676 -1.91163750300448 -1 12.8542448160137 786 287 125 192 162 835 608 505 309 106 791 246 M18202 GO_AMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. 35/43 Gene Ontology MF GO:0004177 6.38213527184512e-07 1.95615192380487e-06 235 411.636363636364 309 5.80194283934958e-08 201 1.35193614302563 -1.55317467480991 -1 7.42806892760194 232 318 530 700 280 309 227 289 689 753 201 247 M18932 GO_NUCLEOSOMAL_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOMAL_DNA_BINDING.html Interacting selectively and non-covalently with the DNA portion of a nucleosome. 46/61 Gene Ontology MF GO:0031492 2.45628585544597e-06 4.57004679656606e-06 35 279 309 2.2329896344342e-07 19 1.36461242918373 1.46688395499395 1 7.01053873120562 33 309 483 344 486 19 60 74 522 678 61 248 M19109 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PENTOSYL_GROUPS.html Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). 48/59 Gene Ontology MF GO:0016763 2.1493017086913e-06 4.21694207514384e-06 155 303.818181818182 309 1.95391255315083e-07 24 1.30191543056107 1.49777845817229 1 6.72992900377541 153 405 584 420 458 31 84 309 255 619 24 249 M18133 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_5_PHOSPHATASE_ACTIVITY.html Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. 12/13 Gene Ontology MF GO:0034595 1.11266448564138e-05 1.55066387001393e-05 190 402.363636363636 310 1.01151828459557e-06 113 1.12128828301213 -1.22826469540368 -1 5.17337465020998 113 702 583 627 651 141 178 187 310 745 189 250 M18873 GO_PEPTIDASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 121/252 Gene Ontology MF GO:0030414 1.10739910598545e-15 6.39522983706599e-14 165 265.818181818182 310 1.00672645998677e-16 2 2.83195427532614 2.99088818202141 1 36.1810505740562 161 2 11 130 310 313 590 497 465 28 417 251 M18390 GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOPHOSPHOLIPID_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. 19/19 Gene Ontology MF GO:0071617 7.92132231701862e-06 1.15264595605121e-05 310 417.727272727273 312 7.20122803516716e-07 151 1.60118303333639 -1.75414085824896 -1 7.61182147635528 310 682 468 694 629 276 261 151 249 563 312 252 M18451 GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. 34/54 Gene Ontology MF GO:0052742 2.18920427003197e-06 4.27901662349675e-06 240 358.727272727273 312 1.99018768045139e-07 151 1.78250335237267 -1.62776121574001 -1 9.22417609977197 237 549 377 241 460 181 266 545 312 627 151 253 M18494 GO_PHOSPHATIDYLSERINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_BINDING.html Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. 43/62 Gene Ontology MF GO:0001786 8.62357765888306e-07 2.29630713452679e-06 315 340.909090909091 313 7.83961912651073e-08 214 2.46429271891867 2.5827775787417 1 13.4200579949819 377 544 230 291 331 214 315 244 623 313 268 254 M19031 GO_DEATH_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_ACTIVITY.html Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. 20/23 Gene Ontology MF GO:0005035 1.97007884513615e-05 2.56387725761381e-05 505 361 313 1.79099680656723e-06 27 2.43670011711353 3.03228839350268 1 10.7928639145598 313 504 299 812 700 176 238 47 502 353 27 255 M18628 GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 77/82 Gene Ontology MF GO:0005089 1.74888571848942e-07 1.65381926038186e-06 315 267.636363636364 315 1.58989623410615e-08 17 2.07958759955299 -2.05496287586062 -1 11.6036581552886 315 28 131 17 44 370 563 673 330 62 411 256 M19054 GO_DOPAMINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a dopamine receptor. 26/31 Gene Ontology MF GO:0050780 7.95779282760362e-07 2.22145032408029e-06 500 330.272727272727 315 7.23435973280076e-08 119 1.88113114176476 -1.9234467764885 -1 10.2571097354273 497 327 286 119 315 503 437 419 245 251 234 257 M18145 GO_ADRENERGIC_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an adrenergic receptor. 26/30 Gene Ontology MF GO:0031690 2.70597441572848e-07 1.66268825097163e-06 110 377.181818181818 316 2.45997704414568e-08 109 1.80633233864059 -1.83214098212994 -1 10.0674294799327 631 110 316 288 109 821 544 259 442 248 381 258 M18560 GO_MYOSIN_HEAVY_CHAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_HEAVY_CHAIN_BINDING.html Interacting selectively and non-covalently with a heavy chain of a myosin complex. 19/27 Gene Ontology MF GO:0032036 1.63372747669001e-07 1.65381926038186e-06 800 335.363636363636 316 1.48520690728289e-08 39 2.31136749345547 2.11278022771068 1 12.9032627028804 797 132 198 52 39 513 642 388 57 316 555 259 M18217 GO_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 116/193 Gene Ontology MF GO:0016247 2.35543052768645e-07 1.65381926038186e-06 615 336.636363636364 317 2.14130070897338e-08 6 2.43106645239792 -2.08265522395506 -1 13.5744223481993 613 6 51 40 81 767 828 395 317 33 572 260 M19063 GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. 14/20 Gene Ontology MF GO:0004198 0.00154093012527373 0.00162166222750903 230 391.181818181818 318 0.000140182771580474 62 2.97276317520498 -2.87186224442935 -1 7.98714266129204 230 693 264 310 871 491 377 318 62 502 185 261 M18571 GO_FERROUS_IRON_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERROUS_IRON_BINDING.html Interacting selectively and non-covalently with ferrous iron, Fe(II). 23/29 Gene Ontology MF GO:0008198 6.95291706283141e-06 1.0412472230237e-05 380 359.181818181818 319 6.32085367004078e-07 89 2.30350582918454 1.75335851799797 1 11.0740680861577 378 422 319 283 611 267 247 204 89 593 538 262 M17972 GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of inorganic cations with a valency of two from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. 113/188 Gene Ontology MF GO:0072509 4.03843506872671e-07 1.70429971387201e-06 385 287.818181818182 320 3.67130528185743e-08 84 2.27771566896762 2.81632102562487 1 12.6857299776926 381 395 90 356 190 320 652 146 347 84 205 263 M18553 GO_ION_CHANNEL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_CHANNEL_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. 122/168 Gene Ontology MF GO:0044325 3.37551974772687e-07 1.69370198541451e-06 405 323.090909090909 321 3.0686547869474e-08 99 2.12530980172446 2.15764417392297 1 11.8386943702833 405 286 123 276 155 321 509 396 472 99 512 264 M17969 GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. 24/29 Gene Ontology MF GO:0016411 5.01323352494009e-06 7.97285331677219e-06 190 407.454545454545 322 4.55749540804081e-07 75 1.54625782850345 -1.63253388078852 -1 7.58882778845467 186 807 486 886 572 143 224 75 322 606 175 265 M18187 GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. 13/18 Gene Ontology MF GO:0004550 6.46072734039705e-07 1.95728264345144e-06 460 307.636363636364 323 5.87339021610538e-08 80 1.61443836518735 1.80966798521993 1 8.88097987603764 254 166 323 358 285 365 372 263 80 460 458 266 M18310 GO_TOXIC_SUBSTANCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIC_SUBSTANCE_BINDING.html Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems. 10/17 Gene Ontology MF GO:0015643 6.18405388985455e-05 7.23299467623495e-05 785 359.636363636364 323 5.62202520576671e-06 49 2.66988826550091 -1.94697556657032 -1 10.664863537462 193 460 253 407 781 280 49 783 345 323 82 267 M17882 GO_CYTOKINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_BINDING.html Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 93/153 Gene Ontology MF GO:0019955 1.1907983472277e-06 2.799739625543e-06 130 339.363636363636 324 1.08254453797634e-07 94 2.31769773333493 2.39760049768194 1 12.4248512365075 130 535 103 578 376 128 232 666 567 94 324 268 M18624 GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_COA_LIGASE_ACTIVITY.html Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 10/14 Gene Ontology MF GO:0004467 7.35159868831552e-07 2.10958918882098e-06 365 346 324 6.68327376813925e-08 207 2.18725483370163 -1.55335364584568 -1 11.98311733962 365 373 263 359 305 409 207 319 237 324 645 269 M17863 GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate from one side of the membrane to the other. 31/38 Gene Ontology MF GO:1901677 2.24422875401651e-07 1.65381926038186e-06 325 404.272727272727 325 2.04020816631928e-08 70 1.76525424459719 1.62163876897514 1 9.84117112208525 719 88 325 319 70 557 461 629 321 164 794 270 M18689 GO_CHOLESTEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 10/18 Gene Ontology MF GO:0017127 2.39904881299079e-05 3.04494657033447e-05 595 410.909090909091 325 2.18097724950847e-06 31 3.49404602886434 4.44079066870401 1 15.2477034717439 591 459 235 154 716 589 846 255 31 325 319 271 M18417 GO_CARBOHYDRATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. 17/20 Gene Ontology MF GO:0019200 8.41453057142801e-07 2.26793305838056e-06 330 432 327 7.64957617255283e-08 106 1.42121903901594 -1.64955734881046 -1 7.72311593956208 312 688 535 713 326 246 327 114 678 707 106 272 M18911 GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. 22/74 Gene Ontology MF GO:0005230 2.82046469861004e-07 1.66268825097163e-06 905 430.909090909091 327 2.56405914563815e-08 44 2.74084884479386 2.59100490911102 1 15.3052175468426 905 111 66 100 123 838 871 725 327 44 630 273 M17911 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_SULFUR_CONTAINING_GROUPS.html Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). 44/77 Gene Ontology MF GO:0016782 8.45441614430122e-07 2.26793305838056e-06 660 358.454545454545 328 7.68583581205858e-08 64 2.37715682509022 2.9150353396631 1 12.9559759950141 659 64 120 351 328 897 628 121 152 163 460 274 M18286 GO_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. 221/269 Gene Ontology MF GO:0035091 2.27747522299505e-07 1.65381926038186e-06 460 334.818181818182 329 2.07043223523906e-08 76 1.89380191573491 -1.91662289820004 -1 10.5619460572192 459 261 306 143 76 451 600 329 234 403 421 275 M18068 GO_PROTEIN_KINASE_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_BINDING.html Interacting selectively and non-covalently with any subunit of protein kinase A. 41/48 Gene Ontology MF GO:0051018 8.2549445164711e-07 2.26337351134104e-06 330 361.545454545455 330 7.50449783084748e-08 104 2.06953106763931 2.18980764554835 1 11.2737685782235 330 311 298 367 321 438 651 463 252 442 104 276 M17890 GO_PROTEIN_KINASE_C_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_BINDING.html Interacting selectively and non-covalently with protein kinase C. 61/75 Gene Ontology MF GO:0005080 4.59643155061156e-07 1.77703044048748e-06 205 339.090909090909 331 4.17857500994395e-08 112 1.87595394308739 1.86056530940739 1 10.4050952189125 204 542 387 331 217 112 250 363 651 421 252 277 M18151 GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. 244/498 Gene Ontology MF GO:0022803 2.18765606443439e-24 3.36899033922897e-22 755 410.636363636364 331 1.9887782403949e-25 2 2.69987380370815 2.88525082309158 1 56.1670685095595 751 251 2 73 86 539 891 797 331 6 790 278 M18977 GO_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 51/126 Gene Ontology MF GO:0005267 7.87337706737147e-09 1.65340918414801e-07 530 304.272727272727 331 7.157615541408e-10 29 2.92297786442207 2.94597636708089 1 19.1676874140844 527 55 37 104 223 331 463 757 444 29 377 279 M17965 GO_TAU_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_BINDING.html Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. 16/20 Gene Ontology MF GO:0048156 6.17140556368238e-07 1.95615192380487e-06 370 344.818181818182 332 5.61037026806918e-08 100 1.6734644866291 2.30127406718713 1 9.2081620189375 370 581 480 332 270 323 180 383 100 637 137 280 M19103 GO_EXTRACELLULAR_GLUTAMATE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_GLUTAMATE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. 9/22 Gene Ontology MF GO:0005234 3.02482672705744e-06 5.37488441500206e-06 195 400.818181818182 332 3.02483084437485e-07 113 2.84581081360559 2.09755997704587 1 14.4871578118747 444 192 914 191 524 266 332 739 142 113 552 281 M19206 GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ETHER_BONDS.html Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. 12/13 Gene Ontology MF GO:0016801 5.03357645440212e-07 1.84352199509307e-06 515 406.727272727273 332 4.57597964189035e-08 175 1.81546630837694 -1.97450997719633 -1 10.0396788423352 511 175 332 400 232 758 748 527 200 312 279 282 M18337 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. 49/79 Gene Ontology MF GO:0015171 8.6936637256348e-07 2.30170351933712e-06 430 350.090909090909 333 7.90333378280152e-08 58 2.36518637597116 2.2634805684008 1 12.8757246700939 426 58 116 258 333 579 683 427 164 142 665 283 M18936 GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. 23/27 Gene Ontology MF GO:0043325 8.21193914561403e-07 2.26337351134104e-06 730 447.545454545455 333 7.46540200989621e-08 48 2.17654229158685 -2.61993308320723 -1 11.8596450617598 728 333 291 48 318 923 784 154 280 519 545 284 M18253 GO_CAMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BINDING.html Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). 18/29 Gene Ontology MF GO:0030552 2.58818484135296e-06 4.76390994703213e-06 250 396.727272727273 334 2.3528980783836e-07 247 2.13884698889832 2.27338001255997 1 10.9828344869876 247 575 290 657 492 253 334 455 295 457 309 285 M18672 GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_SODIUM_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). 18/36 Gene Ontology MF GO:0005343 8.73362365602262e-07 2.30567664518997e-06 825 415.545454545455 334 7.93966102102159e-08 56 3.3895490133289 -4.44791099526922 -1 18.4743070532386 825 144 112 56 334 811 497 856 116 208 612 286 M18518 GO_CHANNEL_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHANNEL_INHIBITOR_ACTIVITY.html Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. 37/62 Gene Ontology MF GO:0016248 8.42127662345304e-07 2.26793305838056e-06 890 490.181818181818 335 7.65570895181426e-08 158 1.79440291464913 1.91178260486767 1 9.7659465762286 890 313 410 158 327 853 845 335 180 298 783 287 M18500 GO_MAP_KINASE_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_KINASE_ACTIVITY.html Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. 22/25 Gene Ontology MF GO:0004709 2.29029851107159e-05 2.91492537772748e-05 500 357 336 2.08211123132013e-06 155 1.58541380489072 -1.8855331534718 -1 6.91676000970998 155 500 415 336 714 329 339 172 293 498 176 288 M18838 GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_COMPLEX_SCAFFOLD_ACTIVITY.html Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. 22/31 Gene Ontology MF GO:0030159 2.74690755241107e-06 5.0160920522289e-06 285 293 336 2.49719180199117e-07 54 3.0898536051326 3.99536592573264 1 15.8242791554859 281 421 148 142 499 336 402 408 54 420 112 289 M18586 GO_ALKALI_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALI_METAL_ION_BINDING.html Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. 19/43 Gene Ontology MF GO:0031420 8.60367182986725e-07 2.29630713452679e-06 795 416.181818181818 337 7.82152290414416e-08 140 2.75949558446164 2.29720873091902 1 15.0344700414733 794 337 140 200 330 548 435 569 209 244 772 290 M18710 GO_KINESIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_BINDING.html Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. 49/60 Gene Ontology MF GO:0019894 2.71534912011188e-07 1.66268825097163e-06 340 371.727272727273 337 2.46849950477618e-08 53 2.24463562054562 -1.59794115237758 -1 12.5240363825753 896 63 159 53 111 775 558 338 109 337 690 291 M18721 GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_PARTICLE_RECEPTOR_ACTIVITY.html Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. 18/21 Gene Ontology MF GO:0030228 3.95474800442372e-05 4.77963754041447e-05 250 425.181818181818 337 3.59529008842403e-06 248 1.99549110806013 2.4816895282684 1 8.30485970940896 248 433 273 489 756 327 284 537 698 295 337 292 M17872 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. 25/30 Gene Ontology MF GO:0035255 4.90051660526897e-06 7.82051354623234e-06 495 330.363636363636 338 4.45502501930975e-07 112 1.61964494679914 -1.46382353923954 -1 7.96485479597759 491 112 392 121 570 338 249 316 461 356 228 293 M18848 GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOLUTE_PROTON_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). 19/28 Gene Ontology MF GO:0015295 7.86309660275839e-07 2.20166704877235e-06 430 334.454545454545 338 7.14827219376048e-08 13 1.82287509123042 -1.64741597747343 -1 9.94457266052139 360 430 430 327 314 328 433 13 141 565 338 294 M17943 GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_CELL_ADHESION.html Any protein binding that is involved in cell adhesion. 18/21 Gene Ontology MF GO:0098631 2.48561669665352e-07 1.65381926038186e-06 535 409.454545454545 339 2.25965179771358e-08 30 2.41387031683316 2.49671041199251 1 13.47800252677 531 339 231 30 90 494 762 874 32 206 915 295 M18423 GO_14_3_3_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_14_3_3_PROTEIN_BINDING.html Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. 38/67 Gene Ontology MF GO:0071889 6.3219676380424e-08 1.12336501875984e-06 500 298.636363636364 339 5.74724347246532e-09 3 1.62471780104774 1.57841838693821 1 9.31783926635849 235 80 405 157 3 273 355 442 339 496 500 296 M18695 GO_PROTEIN_PHOSPHATASE_1_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_1_BINDING.html Interacting selectively and non-covalently with the enzyme protein phosphatase 1. 19/30 Gene Ontology MF GO:0008157 9.03516399879431e-07 2.34959513025491e-06 155 323.181818181818 339 8.21378882676489e-08 114 1.6906361322677 -2.13883865855639 -1 9.1727318502818 151 342 428 541 339 212 114 366 186 634 242 297 M17877 GO_LONG_CHAIN_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 14/26 Gene Ontology MF GO:0036041 2.01575349778049e-05 2.61263906240459e-05 340 352.181818181818 340 1.83251997035535e-06 65 3.02025170213552 -3.95860819010372 -1 13.367203345062 340 587 261 242 702 468 366 65 228 396 219 298 M18016 GO_ENHANCER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENHANCER_BINDING.html Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. 100/142 Gene Ontology MF GO:0035326 3.17831224343951e-06 5.5825487663865e-06 245 304.454545454545 340 2.8893789410149e-07 21 1.74194578048593 1.7779840009874 1 8.81790177790585 244 21 348 340 516 190 379 163 599 368 181 299 M18706 GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a substance from one side of a membrane to the other. 647/1090 Gene Ontology MF GO:0022857 3.35034545505469e-13 1.28988300019606e-11 595 382.636363636364 340 3.3503454550552e-14 11 2.37816111074847 -2.30972213686936 -1 25.0587447165343 436 237 874 247 143 593 595 340 264 11 469 300 M18248 GO_METALLOENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 78/124 Gene Ontology MF GO:0004222 8.35942204630349e-07 2.26793305838056e-06 345 349.090909090909 341 7.59947747515086e-08 88 2.6277241811983 2.76922317841624 1 14.3275965419566 220 539 88 577 324 341 505 233 494 174 345 301 M18267 GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSLOCATING_ATPASE_ACTIVITY.html Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP. 20/26 Gene Ontology MF GO:0004012 9.30896984121959e-06 1.33563480330542e-05 345 396.363636363636 341 8.46273566451072e-07 55 2.77845859000864 -2.06854960771099 -1 13.0777112192225 341 336 257 221 637 436 306 747 55 429 595 302 M18636 GO_FOUR_WAY_JUNCTION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOUR_WAY_JUNCTION_DNA_BINDING.html Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. 15/18 Gene Ontology MF GO:0000400 1.37634302416457e-05 1.8674610195713e-05 90 326.454545454545 341 1.25122875889635e-06 36 1.33768281640471 1.3678233004822 1 6.0779796766895 86 591 569 341 669 42 36 89 738 343 87 303 M18319 GO_RRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. 15/16 Gene Ontology MF GO:0008649 9.21983354569951e-07 2.37964418889004e-06 200 416.454545454545 342 8.38167037234584e-08 16 0.969256187422793 0.855312665367641 1 5.229415421757 198 589 634 786 342 33 16 313 829 685 156 304 M18661 GO_MAP_KINASE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. 13/14 Gene Ontology MF GO:0033549 1.73417556056885e-07 1.65381926038186e-06 345 331.545454545455 342 1.57652336115207e-08 42 1.88954185069968 -1.74717569900135 -1 10.5380596027059 342 360 297 615 42 444 305 133 515 188 406 305 M18822 GO_GTPASE_ACTIVATING_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVATING_PROTEIN_BINDING.html Interacting selectively and non-covalently with a GTPase activating protein. 31/36 Gene Ontology MF GO:0032794 4.27103579805757e-06 6.99387786154691e-06 305 363 343 3.88276735434836e-07 92 1.83757459727016 2.39499773474594 1 9.1306535994027 301 321 279 472 552 424 577 92 248 384 343 306 M18136 GO_GLUCOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. 7/12 Gene Ontology MF GO:0015926 5.96865620906575e-06 9.11022900062218e-06 345 387.272727272727 345 5.96867224031197e-07 19 1.91328107016984 -2.28016024905247 -1 9.29612735337598 345 600 828 425 606 134 19 225 25 739 314 307 M17891 GO_BETA_2_MICROGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_2_MICROGLOBULIN_BINDING.html Interacting selectively and non-covalently with beta-2-microglobulin. 24/41 Gene Ontology MF GO:0030881 2.81137303029536e-05 3.50095509433006e-05 25 376.181818181818 346 2.55582632489545e-06 23 1.34507338585044 -1.07912429074468 -1 5.75583294686362 23 329 412 538 733 157 231 247 721 401 346 308 M18445 GO_PYRIDOXAL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDOXAL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. 40/53 Gene Ontology MF GO:0030170 7.56486839507411e-07 2.13759584007599e-06 300 417.909090909091 346 6.87715545119388e-08 275 1.97934677679889 -2.21459190826846 -1 10.8276834385406 346 312 296 653 309 296 404 736 554 416 275 309 M17986 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_3_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 18/29 Gene Ontology MF GO:0016894 1.64631373751897e-07 1.65381926038186e-06 550 374.272727272727 347 1.49664896428787e-08 41 1.55541534047369 1.50307288898532 1 8.66459109407243 550 347 479 743 41 247 146 268 627 365 304 310 M19156 GO_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. 867/1395 Gene Ontology MF GO:0005215 2.41019725308405e-07 1.65381926038186e-06 385 376.272727272727 348 2.41019751449137e-08 32 2.22783496185133 -2.18513463280453 -1 12.4348905066697 383 231 918 348 169 551 579 214 286 32 428 311 M18226 GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_DIESTER_HYDROLASE_ACTIVITY.html Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. 65/94 Gene Ontology MF GO:0008081 9.70405744673332e-07 2.44987679802776e-06 910 407.818181818182 349 8.82187429739349e-08 101 2.33326974840764 1.83368955039384 1 12.6398977914244 907 300 166 389 349 563 836 236 381 101 258 312 M18238 GO_STEROID_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_ACTIVITY.html Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. 42/63 Gene Ontology MF GO:0003707 3.29172347211629e-06 5.71720392525461e-06 150 365.545454545455 349 2.99248036120741e-07 114 1.75857348049074 -1.78753394334285 -1 8.88496025622757 147 624 433 556 522 177 233 142 724 349 114 313 M18459 GO_G_PROTEIN_COUPLED_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PHOTORECEPTOR_ACTIVITY.html Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 4/9 Gene Ontology MF GO:0008020 3.5912729803642e-06 6.13370838051112e-06 285 352.909090909091 350 3.59127878413612e-07 27 3.43254883615681 4.46818937005622 1 17.2948271831202 282 386 859 315 540 379 543 27 149 350 52 314 M18907 GO_PDZ_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PDZ_DOMAIN_BINDING.html Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins. 106/141 Gene Ontology MF GO:0030165 3.6474179039411e-07 1.69370198541451e-06 580 369.272727272727 350 3.31583500786631e-08 171 1.9312393614751 -1.71653490782443 -1 10.752476942327 578 292 288 360 171 456 288 580 350 242 457 315 M18939 GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate. 11/28 Gene Ontology MF GO:0030898 9.73693766502966e-07 2.45147967370229e-06 285 299.909090909091 350 8.85176543134985e-08 24 2.64924867687433 2.68806775344805 1 14.3585851485959 284 455 361 159 350 390 572 51 24 483 170 316 M18421 GO_ADENOSINE_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOSINE_DEAMINASE_ACTIVITY.html Catalysis of the reaction: adenosine + H2O = inosine + NH3. 8/10 Gene Ontology MF GO:0004000 5.35930754583488e-07 1.87024687461194e-06 355 356.909090909091 351 5.35930883833329e-08 53 2.23519232471959 -2.94941268517624 -1 12.360362314725 351 381 856 416 262 249 203 553 133 469 53 317 M18909 GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a potassium channel. 40/60 Gene Ontology MF GO:0015459 9.7703914001843e-07 2.45321784069845e-06 900 354.909090909091 351 8.88217794482073e-08 61 2.58341298668419 -2.28187015712147 -1 13.9995834350428 899 69 109 61 351 618 363 563 182 87 602 318 M19057 GO_NEUROPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_BINDING.html Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). 4/38 Gene Ontology MF GO:0042923 4.14218860541084e-06 6.84683769481148e-06 615 427.636363636364 351 4.14219632640799e-07 11 4.0468564149337 -1.60900889471203 -1 20.212681408308 611 218 910 46 562 920 735 274 11 351 66 319 M18019 GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 20/21 Gene Ontology MF GO:0030676 2.4245102604388e-06 4.55334853789727e-06 220 327.454545454545 352 2.20410266579522e-07 127 1.8105724692822 -1.69078171231789 -1 9.32293513667683 219 127 300 465 482 263 157 488 361 352 388 320 M18569 GO_MICROFILAMENT_MOTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROFILAMENT_MOTOR_ACTIVITY.html Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 15/31 Gene Ontology MF GO:0000146 5.58283592954786e-07 1.88105729843001e-06 530 339.181818181818 352 5.07530667843476e-08 7 3.13936977444246 -2.87313218252431 -1 17.3756857867722 528 352 236 37 253 415 264 710 7 434 495 321 M18528 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the transforming growth factor beta receptor. 37/59 Gene Ontology MF GO:0005160 7.780138554576e-08 1.28372286150504e-06 515 395.454545454545 353 7.07285348155903e-09 7 2.12961166352829 2.14612173244716 1 12.1113698011335 512 315 199 180 7 553 839 586 353 237 569 322 M17910 GO_VITAMIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 28/33 Gene Ontology MF GO:0051183 1.00566354617409e-06 2.50467147349019e-06 920 471.636363636364 354 9.1424000534827e-08 103 2.62483219781807 -2.09489980648741 -1 14.2019966430589 918 103 121 257 354 497 876 911 111 192 848 323 M18948 GO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVITY.html Combining with an extracellular or intracellular messenger to initiate a change in cell activity. 729/2329 Gene Ontology MF GO:0004872 3.10356558831065e-43 2.86769460359904e-40 5 377.545454545455 354 3.10356558831065e-44 1 2.60908645880657 2.72160632958448 1 100 431 233 900 1 177 94 779 680 354 1 503 324 M18364 GO_DIACYLGLYCEROL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_BINDING.html Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids. 11/14 Gene Ontology MF GO:0019992 9.79103189422231e-06 1.3935816435452e-05 505 410.272727272727 356 8.90097769925287e-07 144 2.52963558472169 -2.15209416291407 -1 11.8562153852412 501 763 356 320 642 586 329 144 299 376 197 325 M18649 GO_CARGO_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARGO_RECEPTOR_ACTIVITY.html Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis. 54/78 Gene Ontology MF GO:0038024 8.59673634703729e-08 1.36249035098998e-06 820 399.090909090909 356 7.81521516633093e-09 42 3.10428565153593 2.88154745104448 1 17.602562461864 820 54 42 169 496 721 853 229 356 56 594 326 M18080 GO_COA_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COA_HYDROLASE_ACTIVITY.html Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. 20/27 Gene Ontology MF GO:0016289 9.0155852199088e-07 2.34959513025491e-06 430 328.909090909091 357 8.19598992226518e-08 85 1.46768822511927 -1.28521371441723 -1 7.95562355972149 85 427 403 479 338 159 120 495 357 428 327 327 M18540 GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of potassium ions (K+) from one side of a membrane to the other. 68/152 Gene Ontology MF GO:0015079 5.47279466043743e-09 1.1760144805219e-07 475 311.818181818182 357 4.97526788550157e-10 30 2.71663617313678 2.71958405580816 1 18.2004246511704 475 34 36 108 357 261 439 774 483 30 433 328 M18548 GO_LIPOPOLYSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_BINDING.html Interacting selectively and non-covalently with lipopolysaccharide. 19/32 Gene Ontology MF GO:0001530 3.82303136475452e-07 1.70429971387201e-06 675 404.545454545455 357 3.47548366281702e-08 113 2.94539969949945 -3.63673016300925 -1 16.4210211339549 675 134 113 183 179 741 357 712 638 315 403 329 M18432 GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 276/334 Gene Ontology MF GO:0005085 5.44810578622552e-07 1.87137790174371e-06 445 345.727272727273 358 4.95282466854663e-08 133 2.02099969991534 -1.92403299969709 -1 11.1699511056303 445 252 136 133 248 461 506 594 358 151 519 330 M18458 GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_CALCIUM_ACTIVATED_CHLORIDE_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. 13/19 Gene Ontology MF GO:0005229 6.54124966407551e-06 9.84383499935793e-06 570 382.545454545455 359 5.94660828474851e-07 52 2.41274307818008 -2.38610298805121 -1 11.6589843792577 567 359 220 141 605 764 678 380 52 262 180 331 M18466 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. 29/46 Gene Ontology MF GO:0043027 5.82323706642586e-06 8.99391445326808e-06 325 358.454545454545 359 5.29386589105474e-07 34 1.9611816634572 -2.08756548929149 -1 9.54089797053427 323 325 278 233 590 432 359 492 404 473 34 332 M19094 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 15/18 Gene Ontology MF GO:0004675 8.21484112716778e-05 9.4292089459665e-05 85 321.909090909091 359 7.46831626082503e-06 82 1.85457906000143 1.93019226262925 1 7.18366752849223 142 582 390 366 796 209 94 82 359 437 84 333 M18392 GO_ENZYME_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of an enzyme. 462/550 Gene Ontology MF GO:0008047 1.21755915176951e-07 1.58112794444989e-06 430 340.909090909091 360 1.10687201741238e-08 22 1.73973679976394 -1.64627652209889 -1 9.73102991166398 427 242 304 300 22 397 479 558 379 282 360 334 M18852 GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with platelet-derived growth factor. 22/23 Gene Ontology MF GO:0048407 0.000282397535984859 0.000306982733235305 10 343.454545454545 360 2.56757992507994e-05 9 2.88186069916408 2.97221772716165 1 9.76146082664224 9 499 79 363 881 220 360 508 575 85 199 335 M18209 GO_GLUTATHIONE_PEROXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_PEROXIDASE_ACTIVITY.html Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. 11/17 Gene Ontology MF GO:0004602 3.9129699735497e-06 6.58576367132956e-06 365 345.181818181818 361 3.55725175751301e-07 60 2.7147669332369 -2.22058709058881 -1 13.5851262808857 361 454 328 317 539 473 245 176 60 482 362 336 M18637 GO_ISOPRENOID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BINDING.html Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 23/53 Gene Ontology MF GO:0019840 2.81181021843789e-07 1.66268825097163e-06 355 351.636363636364 361 2.55619143437652e-08 120 2.39609054340949 2.62399250324651 1 13.3729125473384 354 120 150 361 121 368 380 822 537 175 480 337 M18901 GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SUBSTRATE_BINDING.html Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. 16/17 Gene Ontology MF GO:0043560 1.26565776109756e-06 2.88046249077375e-06 510 399.454545454545 361 1.15059862657251e-07 230 1.35527888353417 -0.864404730375635 -1 7.22568037423201 297 510 507 343 391 281 361 322 230 742 410 338 M17921 GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a sulfur compound from one side of the membrane to the other. 17/29 Gene Ontology MF GO:1901682 3.36770881526672e-06 5.82727143315815e-06 175 363.545454545455 362 3.06155815498916e-07 53 1.95411463885381 -1.94230132318426 -1 9.86351831815853 175 637 362 699 526 169 190 53 419 422 347 339 M18295 GO_CATION_SUGAR_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_SUGAR_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). 13/16 Gene Ontology MF GO:0005402 1.11432988061607e-05 1.55066387001393e-05 275 361.636363636364 363 1.01303229535299e-06 25 2.15227974066558 -1.75835027916284 -1 9.98229335367659 271 518 372 223 736 357 491 25 68 554 363 340 M18816 GO_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a growth factor receptor. 122/186 Gene Ontology MF GO:0070851 2.00666597818056e-07 1.65381926038186e-06 525 377.272727272727 363 1.82424196473889e-08 10 2.18519921073358 -2.23018723512586 -1 12.1958291493203 521 10 134 518 55 733 681 299 363 310 526 341 M17974 GO_PROTEIN_PHOSPHATASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_BINDING.html Interacting selectively and non-covalently with any protein phosphatase. 166/199 Gene Ontology MF GO:0019903 2.48354658121375e-07 1.65381926038186e-06 540 361.545454545455 364 2.25776987416145e-08 69 1.85047152734096 -1.75831993257677 -1 10.3189898246593 540 273 272 69 89 635 594 435 166 364 540 342 M18388 GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 215/261 Gene Ontology MF GO:0005088 3.32465722335308e-07 1.69329794462269e-06 670 389.545454545455 366 3.02241611434362e-08 12 2.12789001314389 -2.08255586483625 -1 11.8533497118491 667 258 57 12 152 705 710 689 366 43 626 343 M18611 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS.html Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). 18/33 Gene Ontology MF GO:0016769 1.62363653588328e-05 2.16797710860716e-05 615 431.545454545455 366 1.47604410792215e-06 160 2.30060023992054 2.13449389465158 1 10.3493943084882 612 345 245 582 683 566 333 160 217 366 638 344 M18278 GO_PEPTIDASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 42/51 Gene Ontology MF GO:0016504 7.85409653982013e-07 2.20166704877235e-06 205 369.545454545455 367 7.14009031251678e-08 150 1.62625724152947 -1.68651613526352 -1 8.86581915051018 364 488 497 422 313 394 202 367 204 664 150 345 M19201 GO_THIOESTERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTERASE_BINDING.html Interacting selectively and non-covalently with any thioesterase enzyme. 15/16 Gene Ontology MF GO:0031996 1.21245733521969e-06 2.815452174354e-06 420 341.454545454545 367 1.10223454856911e-07 125 1.27840879400506 -1.30716783391193 -1 6.82492150157647 417 149 493 232 380 367 165 356 125 610 462 346 M18472 GO_ALPHA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin. 28/35 Gene Ontology MF GO:0043014 4.58738612286064e-06 7.38457278314151e-06 175 341 368 4.1703597167216e-07 76 2.12459822695782 -1.60538891912738 -1 10.5170512317879 174 496 368 418 563 122 76 663 168 444 259 347 M18862 GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. 27/43 Gene Ontology MF GO:0005310 2.43245677277048e-06 4.55364038161766e-06 920 466.636363636364 368 2.2113267838637e-07 108 2.52984494094832 -3.07789086236382 -1 13.0490522059638 919 108 154 195 483 845 881 368 216 133 831 348 M18132 GO_GTPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. 18/20 Gene Ontology MF GO:0005095 5.59230114916218e-06 8.71380482601324e-06 915 473.818181818182 369 5.0839230587191e-07 140 1.67250650611935 1.9641665730333 1 8.15046953706571 912 140 351 369 586 670 648 311 231 294 700 349 M18314 GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_DISSOCIATION_INHIBITOR_ACTIVITY.html Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. 10/11 Gene Ontology MF GO:0005092 7.10301530663944e-07 2.07695764029584e-06 710 376.454545454545 369 6.45728872722798e-08 29 1.46266035417656 -0.828893484085868 -1 8.00415955158631 709 173 369 147 297 793 667 118 29 439 400 350 M18026 GO_PROTEIN_LIPID_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_BINDING.html Interacting selectively and non-covalently with a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. 23/37 Gene Ontology MF GO:0071814 2.48892518679282e-06 4.59953374519313e-06 460 344.818181818182 370 2.26266182053826e-07 120 2.84611809973319 2.82382966820841 1 14.6754732027843 432 335 141 209 490 457 365 120 458 370 416 351 M18276 GO_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_ACTIVITY.html Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 9/27 Gene Ontology MF GO:0008066 1.02605492342127e-06 2.53495922257019e-06 800 473.727272727273 370 1.02605539717649e-07 112 2.92540461057364 1.86728623541517 1 15.8199676273946 798 194 840 153 370 674 698 869 161 112 342 352 M18755 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. 110/216 Gene Ontology MF GO:0016705 3.98498106956372e-07 1.70429971387201e-06 790 470 370 3.62271071944131e-08 169 2.19203797059113 2.22107580054625 1 12.206414711189 787 291 169 738 186 849 639 345 563 233 370 353 M19051 GO_METALLOAMINOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOAMINOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 12/13 Gene Ontology MF GO:0070006 4.4100475844377e-07 1.74692110295557e-06 305 446.909090909091 370 4.00913497132871e-08 207 1.10097710681996 -1.1141948355511 -1 6.09113027426599 304 370 551 706 207 330 220 416 766 691 355 354 M17945 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR). 11/29 Gene Ontology MF GO:0005104 1.22344787632382e-06 2.817235534876e-06 180 341.363636363636 372 1.11222596063565e-07 32 3.11582089727541 3.94788224362882 1 16.7148341619429 180 456 167 473 384 144 179 851 517 372 32 355 M18291 GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS.html Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 30/40 Gene Ontology MF GO:0016877 6.41424876786255e-07 1.95615192380487e-06 330 411.272727272727 372 5.831136943619e-08 254 1.60085725168509 -1.50945152483188 -1 8.80618303364405 328 324 470 586 281 433 291 372 254 614 571 356 M18473 GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_EXTRACELLULAR_LIGAND_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels. 20/55 Gene Ontology MF GO:0005231 2.74374452524544e-07 1.66268825097163e-06 850 451.272727272727 372 2.49431351584855e-08 53 2.72548386256013 2.64383628687229 1 15.2190997307717 849 121 75 106 114 788 920 674 372 53 892 357 M18022 GO_PHOTORECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_ACTIVITY.html The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. 7/12 Gene Ontology MF GO:0009881 1.67406851185111e-06 3.48387230844691e-06 140 373.272727272727 373 1.67406977297987e-07 138 3.17560869715528 -2.52931836070481 -1 16.7525775446222 513 207 814 394 438 373 140 570 138 170 349 358 M18716 GO_PROTEIN_KINASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVITY.html Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. 14/16 Gene Ontology MF GO:0004697 1.55406160229062e-06 3.32164309585458e-06 590 407.181818181818 373 1.41278427278893e-07 68 1.80695983501037 -1.53868653996502 -1 9.5442651693077 589 356 373 68 416 714 801 303 103 307 449 359 M18898 GO_CULLIN_FAMILY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_FAMILY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). 15/16 Gene Ontology MF GO:0097602 4.50046073506898e-05 5.37264304806684e-05 95 371.181818181818 374 4.09141163819044e-06 24 1.17026599890691 1.25795924103222 1 4.78932301179814 94 585 590 599 766 80 24 119 374 609 243 360 M19026 GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_CHEMOATTRACTANT_RECEPTOR_ACTIVITY.html Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 6/26 Gene Ontology MF GO:0001637 1.06907957064406e-06 2.60506436363068e-06 700 449.818181818182 374 1.06908008496341e-07 92 3.47663577046622 3.07626842756925 1 18.7716502038981 699 215 906 187 374 701 342 587 92 204 641 361 M18508 GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the rate of NTP hydrolysis by a NTPase. 334/380 Gene Ontology MF GO:0060589 1.28453943615161e-07 1.58255258533878e-06 705 456.818181818182 375 1.16776319195773e-08 25 1.69598218406378 -1.49568504500576 -1 9.48422330399153 705 247 375 299 25 700 602 852 367 166 687 362 M18514 GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_1_ACYLHYDROLASE_ACTIVITY.html Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. 9/12 Gene Ontology MF GO:0008970 2.36943222513836e-06 4.47720935793015e-06 195 367.454545454545 375 2.36943475153623e-07 1 2.80497838936471 -2.93245165373459 -1 14.4943695622932 191 375 864 217 494 156 45 867 441 391 1 363 M18603 GO_SPECTRIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECTRIN_BINDING.html Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. 29/40 Gene Ontology MF GO:0030507 3.33528383031742e-07 1.69329794462269e-06 795 444.909090909091 375 3.03207666905388e-08 101 1.90611640092729 -1.87397567545988 -1 10.6120546060302 792 415 333 222 154 922 723 375 101 273 584 364 M18141 GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7. 9/14 Gene Ontology MF GO:0015172 2.78254807901797e-06 5.06117012797758e-06 830 368.090909090909 377 2.78255156318233e-07 50 2.8113341278003 2.09501347476174 1 14.3821717300203 144 377 829 482 510 126 50 826 156 390 159 365 M18993 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the tumor necrosis factor receptor. 25/34 Gene Ontology MF GO:0005164 1.19410538324561e-06 2.80038927441355e-06 240 415.727272727273 378 1.08555093761532e-07 100 1.88745213709832 -1.99928928730416 -1 10.1076512819236 238 564 407 539 378 314 375 100 877 568 213 366 M18748 GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_HYDROLYZING_N_GLYCOSYL_COMPOUNDS.html Catalysis of the hydrolysis of any N-glycosyl bond. 21/26 Gene Ontology MF GO:0016799 2.08328200606912e-05 2.68848124805568e-05 45 299.727272727273 379 1.89391066717628e-06 40 2.11081317652396 1.99286321672159 1 9.29963777231425 40 568 379 410 706 44 42 127 447 385 149 367 M18751 GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HORMONE_RECEPTOR_ACTIVITY.html Combining with a protein hormone to initiate a change in cell activity. 6/23 Gene Ontology MF GO:0016500 1.31132504643838e-05 1.78929593298814e-05 120 404.727272727273 379 1.31133278458284e-06 62 1.48132882750017 -1.22937544467369 -1 6.7634270333264 125 471 879 379 674 145 118 62 856 623 120 368 M18407 GO_FIBROBLAST_GROWTH_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_BINDING.html Interacting selectively and non-covalently with a fibroblast growth factor. 35/55 Gene Ontology MF GO:0017134 2.81696714065533e-06 5.10748493689811e-06 185 363.181818181818 380 2.56088249783464e-07 46 1.92515645135065 2.66415016861031 1 9.82341431050698 181 668 380 501 500 136 210 88 690 595 46 369 M18551 GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYPEPTIDE_N_ACETYLGALACTOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. 15/22 Gene Ontology MF GO:0004653 2.51013877501514e-07 1.65381926038186e-06 455 336.454545454545 381 2.2819446012864e-08 92 3.32216075501036 3.63909532283177 1 18.5708445507893 454 159 133 395 92 381 534 546 542 256 209 370 M17940 GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. 36/38 Gene Ontology MF GO:0004003 1.44361968329622e-05 1.94730596695724e-05 90 394.727272727273 382 1.31239014207481e-06 33 1.33649208713456 1.51132888951362 1 6.04895119333661 88 740 659 382 675 64 33 254 568 665 214 371 M18221 GO_PHOSPHOLIPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_BINDING.html Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. 23/29 Gene Ontology MF GO:0043274 9.69836844763466e-07 2.44987679802776e-06 575 430.909090909091 382 8.81670247546986e-08 160 1.85071528998112 2.01048585855106 1 10.0140504672056 575 332 382 160 348 617 629 239 735 449 274 372 M18401 GO_FATTY_ACID_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORTER_ACTIVITY.html Enables the directed movement of fatty acids into, out of or within a cell, or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 7/20 Gene Ontology MF GO:0015245 5.92660690933844e-06 9.06884354627779e-06 770 474.454545454545 382 5.92662271549902e-07 227 2.68948312280056 -1.39563484406277 -1 13.0956571131276 768 380 854 227 603 508 262 382 235 284 716 373 M18054 GO_NUCLEOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_BINDING.html Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. 64/80 Gene Ontology MF GO:0031491 2.46914173390669e-06 4.58129912074254e-06 65 304.909090909091 383 2.24467682283686e-07 26 1.33648499628661 1.47352527991605 1 6.86348385448351 36 401 545 383 488 26 62 67 518 766 62 374 M18638 GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_CATALYTIC_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A. 20/21 Gene Ontology MF GO:0034236 1.62089144047585e-07 1.65381926038186e-06 440 358 384 1.47353778172554e-08 38 1.90857059256766 1.84912083017636 1 10.6447549637667 439 425 342 287 38 504 606 384 88 512 313 375 M17962 GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_SULFOTRANSFERASE_ACTIVITY.html Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. 10/15 Gene Ontology MF GO:0034483 1.22568039504345e-06 2.817235534876e-06 780 396.909090909091 385 1.11425552536744e-07 64 2.6388841904994 3.61885737545544 1 14.1476229294774 780 597 268 651 385 488 68 64 247 438 380 376 M18733 GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_BINDING.html Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. 44/54 Gene Ontology MF GO:0043548 4.09121746554776e-07 1.70429971387201e-06 70 358.909090909091 386 3.71928929669899e-08 67 1.85222230181881 -1.94937807563807 -1 10.3053501293184 548 67 321 67 191 386 409 460 408 338 753 377 M18787 GO_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 71/84 Gene Ontology MF GO:0019209 1.98478946082789e-07 1.65381926038186e-06 520 367.818181818182 387 1.80435421808278e-08 39 1.75433791668678 -1.75485978718678 -1 9.77996257997878 517 39 339 239 52 419 462 890 387 408 294 378 M19091 GO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_BINDING.html Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. 342/380 Gene Ontology MF GO:0051020 2.72332530504191e-07 1.66268825097163e-06 295 384.909090909091 388 2.47575058377785e-08 113 1.54138800822412 -1.51073665946991 -1 8.58246667498121 293 388 667 399 113 369 440 433 319 550 263 379 M18842 GO_MYOSIN_V_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_V_BINDING.html Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. 18/22 Gene Ontology MF GO:0031489 2.5257966306521e-05 3.17961319716968e-05 420 385.090909090909 389 2.29620511774638e-06 50 1.85858937365146 -1.67506255870309 -1 8.05029036384322 416 578 389 525 723 356 168 304 268 459 50 380 M19069 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC.html Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 16/18 Gene Ontology MF GO:0000983 4.92171359905e-06 7.84079890607276e-06 320 429.181818181818 391 4.47429509969034e-07 158 2.29180121705388 -2.12044161315139 -1 11.2913261944754 391 756 317 380 571 353 158 317 509 561 408 381 M17894 GO_PHOSPHOPROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_BINDING.html Interacting selectively and non-covalently with a phosphorylated protein. 69/84 Gene Ontology MF GO:0051219 1.20567705409482e-07 1.58112794444989e-06 465 361.818181818182 392 1.09607010924559e-08 19 1.61964283549611 1.72913960895634 1 9.05538182600573 463 45 496 289 19 262 384 487 552 591 392 382 M18697 GO_CHEMOATTRACTANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOATTRACTANT_ACTIVITY.html Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. 22/29 Gene Ontology MF GO:0042056 2.81479428404023e-07 1.66268825097163e-06 125 344.181818181818 392 2.55890422198155e-08 92 3.24430176525787 2.93870261632407 1 18.1269758375675 468 124 92 404 122 311 392 705 430 158 580 383 M18262 GO_DAMAGED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DAMAGED_DNA_BINDING.html Interacting selectively and non-covalently with damaged DNA. 67/77 Gene Ontology MF GO:0003684 2.51839750363581e-05 3.17462386542904e-05 65 418.454545454545 393 2.28947848441119e-06 61 1.61547587593387 1.63930628742175 1 6.9909181250471 90 731 617 682 722 63 61 230 393 694 320 384 M18348 GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. 316/410 Gene Ontology MF GO:0042578 3.83870484115781e-07 1.70429971387201e-06 390 497.181818181818 395 3.48973228269133e-08 180 1.84909842440727 1.87353431012799 1 10.2878739113246 765 389 395 388 180 351 645 700 413 342 901 385 M18449 GO_ATPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_BINDING.html Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP. 92/113 Gene Ontology MF GO:0051117 1.26268703360434e-06 2.88046249077375e-06 260 385.181818181818 397 1.14789796211131e-07 244 1.79406620877457 -1.8537216756798 -1 9.5834427277861 483 397 451 286 390 450 562 457 259 258 244 386 M18918 GO_SIGNALING_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNALING_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. 68/96 Gene Ontology MF GO:0035591 5.6684708413837e-07 1.88405289835919e-06 255 350.818181818182 397 5.15315663809979e-08 44 1.56857048784529 -1.62435240330079 -1 8.65224291024605 253 44 434 401 258 229 265 723 410 445 397 387 M18010 GO_RETINOIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_BINDING.html Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. 8/31 Gene Ontology MF GO:0001972 1.07964778690663e-05 1.51610114757102e-05 400 475.272727272727 399 1.07965303231955e-06 229 2.5756228232361 3.37854259154984 1 11.9813725270363 536 527 812 376 657 399 647 397 315 333 229 388 M19155 GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. 45/52 Gene Ontology MF GO:0019205 3.64017406477698e-07 1.69370198541451e-06 410 356.545454545455 399 3.30924969735388e-08 170 1.55224739228611 1.75942474585955 1 8.63124878692291 276 407 492 486 170 228 311 426 399 410 317 389 M18288 GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_BINDING.html Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. 41/59 Gene Ontology MF GO:0050431 3.43355825452129e-06 5.91904445368969e-06 290 397 401 3.12142146665078e-07 202 2.41485351947853 2.48664165086663 1 12.1866073202685 290 546 202 272 528 355 408 612 401 326 427 390 M18420 GO_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOOXYGENASE_ACTIVITY.html Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. 51/149 Gene Ontology MF GO:0004497 3.22720774400192e-07 1.69329794462269e-06 60 356.454545454545 402 2.93382565218654e-08 59 2.87665427974835 2.7491388094144 1 16.0442785164916 552 402 59 575 144 431 486 314 544 60 354 391 M18114 GO_COLLAGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_BINDING.html Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 85/105 Gene Ontology MF GO:0005518 3.04574013008489e-06 5.4016581193828e-06 15 392.636363636364 403 2.76885849699904e-07 15 2.63338174548621 2.82491301322298 1 13.3960006953068 15 537 56 648 797 346 420 403 639 129 329 392 M18418 GO_BINDING_BRIDGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_BRIDGING.html The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. 183/250 Gene Ontology MF GO:0060090 3.3284556157569e-07 1.69329794462269e-06 580 439.363636363636 403 3.02586919939136e-08 111 1.86434246227419 -1.68108650419429 -1 10.3782405598838 576 271 187 391 153 578 589 881 403 111 693 393 M18641 GO_MHC_CLASS_I_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 33/68 Gene Ontology MF GO:0042288 1.25550902505386e-05 1.72120228360499e-05 120 413.272727272727 403 1.14137835465849e-06 110 1.09177968284896 -1.02687785004015 -1 4.98775542648304 120 319 585 554 664 124 403 220 830 617 110 394 M18879 GO_PEPTIDOGLYCAN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDOGLYCAN_BINDING.html Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. 7/26 Gene Ontology MF GO:0042834 6.27991542032286e-06 9.4969588353164e-06 45 406.181818181818 406 6.2799331671954e-07 1 1.71967782019971 -1.71967782019971 -1 8.31960835704911 42 647 892 491 761 9 1 217 837 406 165 395 M18897 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 113/180 Gene Ontology MF GO:0016614 1.07134681621175e-06 2.60506436363068e-06 475 365.363636363636 406 9.73952125392825e-08 189 1.738041499415 -1.9852638588116 -1 9.3559676576823 201 290 465 406 364 420 471 189 439 474 300 396 M19110 GO_NUCLEOTIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. 25/28 Gene Ontology MF GO:0019201 1.40734150622321e-06 3.08147761078257e-06 490 413.454545454545 406 1.27940218772849e-07 212 2.07961220463218 2.55923613064361 1 11.0586966040531 487 497 301 277 406 455 561 789 212 229 334 397 M18814 GO_1_PHOSPHATIDYLINOSITOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 19/24 Gene Ontology MF GO:0005545 5.40250064646846e-06 8.4752302161916e-06 475 435.454545454545 407 4.91137628485296e-07 318 1.85327912294161 -1.68338288612056 -1 9.05921207686329 473 338 449 370 581 407 345 452 332 318 725 398 M18648 GO_CARBON_SULFUR_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_SULFUR_LYASE_ACTIVITY.html Catalysis of the elimination of hydrogen sulfide or substituted H2S. 10/13 Gene Ontology MF GO:0016846 1.10433942426611e-05 1.54373619973054e-05 390 422.636363636364 408 1.00394997071355e-06 24 1.57387471998379 -1.69706845047408 -1 7.28737038887575 386 371 442 408 772 628 868 24 127 545 78 399 M17862 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase. 30/31 Gene Ontology MF GO:0051019 1.03708224617708e-06 2.55537065458032e-06 245 387.727272727273 409 9.42802486417297e-08 211 1.76693406848353 -1.68332348960714 -1 9.52677443463163 243 493 444 485 360 295 211 557 271 497 409 400 M19198 GO_OXIDIZED_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDIZED_NAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. 17/18 Gene Ontology MF GO:0070403 1.4667870180329e-06 3.18896754038213e-06 410 437.727272727273 409 1.33344363270188e-07 70 2.28865172513532 -2.38957064112802 -1 12.1429496746774 584 436 341 70 409 810 690 188 406 506 375 401 M19042 GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). 10/23 Gene Ontology MF GO:0005416 4.0139882244633e-06 6.70691703328045e-06 450 402.454545454545 410 3.64908686196772e-07 203 2.86661225538317 1.64922079771295 1 14.3261474583303 446 374 203 231 543 410 290 672 241 441 576 402 M19137 GO_AMMONIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_BINDING.html Interacting selectively and non-covalently with ammonium ions (NH4+). 31/79 Gene Ontology MF GO:0070405 1.48748266572094e-06 3.22637085240879e-06 490 347.363636363636 410 1.35225788313753e-07 41 2.6040822418557 2.73713066113967 1 13.8115641787469 640 322 177 41 410 490 487 544 78 197 435 403 M18543 GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol bisphosphate. 90/118 Gene Ontology MF GO:1902936 2.41804885423191e-07 1.65381926038186e-06 925 415.818181818182 411 2.19822647272989e-08 24 2.24793967446489 2.05862705839302 1 12.5476189038602 922 24 180 58 84 604 802 471 218 411 800 404 M19151 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS.html Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. 114/156 Gene Ontology MF GO:0016810 1.63976743207412e-06 3.42808923091388e-06 380 454.363636363636 414 1.49069877661285e-07 11 1.76002421463166 1.78191720739229 1 9.27149707533816 823 11 414 402 424 377 477 678 226 379 787 405 M18632 GO_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BINDING.html Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. 50/96 Gene Ontology MF GO:0042562 2.61046275113005e-07 1.66268825097163e-06 535 396.636363636364 415 2.37314823716438e-08 99 2.32804576053132 -2.11305273656723 -1 12.9915344235406 646 486 165 415 99 667 532 250 533 259 311 406 M18808 GO_POTASSIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_BINDING.html Interacting selectively and non-covalently with potassium (K+) ions. 12/25 Gene Ontology MF GO:0030955 1.57641279486314e-06 3.34851821253687e-06 420 466.272727272727 417 1.43310356767715e-07 49 1.85089976704753 -2.55293097133038 -1 9.77145069278373 684 365 308 293 420 905 829 49 666 417 193 407 M19209 GO_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY.html Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 376/431 Gene Ontology MF GO:0016874 1.01375651407872e-06 2.51128959519769e-06 340 560.727272727273 417 9.21597255651289e-08 261 1.24940224560684 -1.27529065908825 -1 6.72894268972151 339 840 797 875 356 395 417 261 626 901 361 408 M18875 GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFURIC_ESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. 12/13 Gene Ontology MF GO:0008484 5.94043662590276e-07 1.92595208502953e-06 460 379.181818181818 418 5.40039839085378e-08 148 1.81714156321905 -1.27352580682388 -1 10.0155165671152 661 174 340 466 265 460 459 490 148 418 290 409 M18950 GO_ACTIN_MONOMER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MONOMER_BINDING.html Interacting selectively and non-covalently with monomeric actin, also known as G-actin. 24/36 Gene Ontology MF GO:0003785 2.2487186598106e-06 4.34566622245621e-06 135 375.545454545455 418 2.04429178030007e-07 68 1.48567352097716 1.3282258412575 1 7.66901116252392 135 418 457 533 467 68 123 670 788 260 212 410 M19001 GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INWARD_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. 14/30 Gene Ontology MF GO:0005242 1.59235887104376e-06 3.36690983259596e-06 420 328 418 1.4476000214486e-07 74 2.60269509459179 2.56985804771394 1 13.7574363704484 657 161 119 199 421 429 476 234 420 74 418 411 M17854 GO_COFACTOR_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORTER_ACTIVITY.html Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. 22/23 Gene Ontology MF GO:0051184 6.33526667973166e-07 1.95615192380487e-06 745 440.636363636364 419 5.7593350037073e-08 45 2.42027179223489 -2.10741044144677 -1 13.3427478236258 743 125 246 398 275 731 597 665 45 419 603 412 M18245 GO_SCAVENGER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCAVENGER_RECEPTOR_ACTIVITY.html Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). 32/49 Gene Ontology MF GO:0005044 8.31626030686971e-07 2.26673289780166e-06 655 373 421 7.56023950046924e-08 50 3.51690053521272 -4.0276821161235 -1 19.1957846482571 654 86 50 168 575 740 701 186 421 68 454 413 M18177 GO_R_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_R_SMAD_BINDING.html Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. 25/30 Gene Ontology MF GO:0070412 2.25778554295223e-07 1.65381926038186e-06 415 453.818181818182 422 2.05253252241923e-08 74 1.53151927223573 -0.98803363692153 -1 8.53060432572625 411 745 526 640 74 222 103 249 836 764 422 414 M18360 GO_RECEPTOR_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_ACTIVATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. 25/40 Gene Ontology MF GO:0030546 2.24322642756024e-06 4.34566622245621e-06 400 435.545454545455 423 2.03929883169609e-07 183 2.2657241559126 -2.37339292113113 -1 11.7253952798209 398 675 311 337 466 529 423 183 768 228 473 415 M18820 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. 35/45 Gene Ontology MF GO:0015932 2.7730417091062e-07 1.66268825097163e-06 405 451.090909090909 423 2.52094732603711e-08 89 1.72548418618009 -2.21624962523121 -1 9.61429089393552 830 89 402 403 117 824 694 156 485 423 539 416 M18976 GO_MHC_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_BINDING.html Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 41/83 Gene Ontology MF GO:0042287 1.63788413612361e-06 3.42808923091388e-06 400 451.181818181818 423 1.48898668683438e-07 68 1.68031043280145 -1.03344178545016 -1 8.84900995595967 400 68 307 355 423 564 910 681 305 443 507 417 M18361 GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. 11/19 Gene Ontology MF GO:0015114 1.79739216130207e-05 2.37255765291873e-05 710 474.636363636364 424 1.63400622372723e-06 72 2.34562986920263 1.79591700618838 1 10.463985104066 707 186 275 224 688 650 822 424 72 375 798 418 M18206 GO_CATECHOLAMINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BINDING.html Interacting selectively and non-covalently with catecholamine. 5/17 Gene Ontology MF GO:1901338 4.95568960778638e-05 5.87812220487114e-05 225 455.727272727273 425 4.95580012612283e-06 213 3.56784018375126 3.56784018375126 1 14.5824994905644 225 530 834 428 773 213 241 782 289 425 273 419 M17869 GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_A_REGULATORY_SUBUNIT_BINDING.html Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A. 19/21 Gene Ontology MF GO:0034237 3.95632303634216e-06 6.64662270105483e-06 400 442.545454545455 426 3.59666377375377e-07 110 2.10547667695516 2.05946465039869 1 10.5152531511883 397 426 314 279 541 511 872 745 110 487 186 420 M18725 GO_CCR_CHEMOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR_CHEMOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a CCR chemokine receptor. 17/50 Gene Ontology MF GO:0048020 8.03215194206493e-05 9.24247620730759e-05 130 477.818181818182 426 7.30222291742529e-06 91 2.10525750480719 -2.23402501479056 -1 8.18006771360323 128 758 426 725 794 142 91 323 843 659 367 421 M19115 GO_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 1297/2125 Gene Ontology MF GO:0005102 6.70790742233074e-27 2.06603548607787e-24 5 437.545454545455 426 6.70790742233078e-28 2 2.23634921087113 2.41211780804155 1 51.3126816835116 574 224 916 2 106 349 867 754 426 3 592 422 M18892 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. 39/49 Gene Ontology MF GO:0001105 5.73447752404004e-07 1.89237758293321e-06 465 458.909090909091 429 5.21316274434401e-08 78 1.85785081245219 2.16135494393546 1 10.2549254748191 462 78 366 339 260 492 855 833 642 292 429 423 M19187 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 23/26 Gene Ontology MF GO:0016645 1.7083010816007e-06 3.52337098080143e-06 430 405.363636363636 429 1.5530021891807e-07 188 1.62441292174303 1.49049607939515 1 8.53399319082344 188 331 429 522 430 388 545 370 498 303 455 424 M18037 GO_FMN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FMN_BINDING.html Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 11/14 Gene Ontology MF GO:0010181 0.000179561386851083 0.000198700265210061 390 503.818181818182 430 1.63250949193686e-05 47 2.66761653436497 -2.10487761167722 -1 9.52030259074006 424 830 388 714 892 389 430 101 846 481 47 425 M18713 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. 38/43 Gene Ontology MF GO:0044390 1.09507338345708e-06 2.62136737387135e-06 665 454.818181818182 430 9.95521753219885e-08 248 1.57338064859973 1.44992364095541 1 8.4600816750103 665 410 527 430 369 708 299 248 341 541 465 426 M18023 GO_CYTOSKELETAL_ADAPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_ADAPTOR_ACTIVITY.html The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way. 15/18 Gene Ontology MF GO:0008093 8.08083656014321e-07 2.23553682083004e-06 650 452 432 7.3462177530208e-08 79 1.57112756799649 -1.15246684209892 -1 8.55324493065263 650 151 374 148 317 669 492 900 79 432 760 427 M18293 GO_MANNOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSE_BINDING.html Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. 10/23 Gene Ontology MF GO:0005537 9.81841612497751e-06 1.3935816435452e-05 80 381.909090909091 432 8.92587267638349e-07 35 0.960895070994128 -0.960895070994128 -1 4.46846892462574 79 464 573 432 644 161 106 98 893 716 35 428 M18688 GO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYASE_ACTIVITY.html Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 154/190 Gene Ontology MF GO:0016829 2.18573710109163e-07 1.65381926038186e-06 760 495.181818181818 432 1.9870339256803e-08 67 1.77016407947767 1.68145793400958 1 9.86870087728173 759 282 432 393 67 906 794 378 446 239 751 429 M19067 GO_TAU_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAU_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. 16/26 Gene Ontology MF GO:0050321 4.281562075047e-07 1.72007102493193e-06 775 454.727272727273 432 3.89232991664516e-08 40 1.66225389144764 -1.34782667687803 -1 9.2361419129403 772 150 404 122 202 832 752 432 40 641 655 430 M17907 GO_PEPTIDASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_REGULATOR_ACTIVITY.html Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. 161/301 Gene Ontology MF GO:0061134 6.40943687496946e-12 2.11511416873992e-10 435 385.636363636364 434 5.82676079544377e-13 22 2.58428043223881 2.78807596069974 1 24.190929211374 434 275 22 131 307 518 809 618 435 41 652 431 M18174 GO_THIOLESTER_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOLESTER_HYDROLASE_ACTIVITY.html Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. 33/40 Gene Ontology MF GO:0016790 2.73875302699374e-05 3.42436779017891e-05 495 396.454545454545 434 2.4898064745351e-06 81 1.45095790751855 -1.4010136014799 -1 6.22691624155582 81 491 495 598 729 160 86 431 434 559 297 432 M17897 GO_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. 98/152 Gene Ontology MF GO:0016597 1.81867243743235e-06 3.71066783908768e-06 555 413.909090909091 435 1.65333994624977e-07 161 2.25938834008912 2.04492852880057 1 11.8427747715855 553 294 161 198 435 225 536 574 576 341 660 433 M18622 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. 16/17 Gene Ontology MF GO:0016646 2.19044898583762e-06 4.27901662349675e-06 205 391.090909090909 435 1.99131924252736e-07 181 1.78660911581252 1.58813254059199 1 9.24555343349663 202 435 400 524 461 375 503 436 181 299 486 434 M19124 GO_EPHRIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an ephrin receptor. 38/43 Gene Ontology MF GO:0046875 2.45813123148629e-06 4.57004679656606e-06 500 395.545454545455 436 2.23466725276382e-07 132 2.11821075193255 2.61156925462573 1 10.9133870085685 496 314 227 471 487 573 737 132 278 200 436 435 M19125 GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_REGULATOR_ACTIVITY.html Modulates the activity of a chloride channel. 14/19 Gene Ontology MF GO:0017081 1.8191910509813e-06 3.71066783908768e-06 540 414.909090909091 436 1.65381141389205e-07 80 1.67860640494783 -1.52992432596788 -1 8.78397686412356 537 357 462 537 436 464 411 80 391 400 489 436 M18619 GO_OXYGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_BINDING.html Interacting selectively and non-covalently with oxygen (O2). 18/94 Gene Ontology MF GO:0019825 5.81670370240204e-06 8.99391445326808e-06 170 403.272727272727 438 5.28792643778996e-07 131 2.66372583653826 -2.60539550112624 -1 12.9790044879978 168 506 210 521 589 201 131 617 688 367 438 437 M18853 GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_NITROGENOUS_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). 10/18 Gene Ontology MF GO:0016775 1.89548564503102e-05 2.4913637781062e-05 485 427.454545454545 440 1.72318361494212e-06 66 1.78759012156514 1.7851082591774 1 7.92425572300344 484 465 367 66 692 543 343 349 566 440 387 438 M17849 GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. 15/25 Gene Ontology MF GO:0004112 5.38404403297378e-07 1.87024687461194e-06 545 414.818181818182 441 4.89458668237038e-08 158 2.11630855699413 1.60198147841821 1 11.6999315938207 542 158 232 462 246 441 716 635 169 186 776 439 M17983 GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMITTER_GATED_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. 8/28 Gene Ontology MF GO:0022835 1.73847148142925e-06 3.57761169006822e-06 745 485.272727272727 441 1.73847284145814e-07 139 2.62549583847188 1.86728623541517 1 13.8113302289568 741 206 809 364 441 426 512 924 275 139 501 440 M18634 GO_3_5_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_DNA_HELICASE_ACTIVITY.html Catalysis of the unwinding of the DNA helix in the direction 3' to 5'. 13/13 Gene Ontology MF GO:0043138 0.000119291136573424 0.000134093686367207 295 476.727272727273 441 1.08452368560808e-05 226 1.61874305195329 1.78749490681276 1 6.02285988758627 295 825 567 441 815 243 226 393 593 555 291 441 M18864 GO_TRANSLATION_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REGULATOR_ACTIVITY.html Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 32/42 Gene Ontology MF GO:0045182 1.16954410155434e-07 1.58112794444989e-06 295 492.909090909091 441 1.06322196702599e-08 18 1.10813675520899 -0.767183795482513 -1 6.17765099202462 294 804 669 832 18 293 99 399 817 756 441 442 M19040 GO_ARYLSULFATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARYLSULFATASE_ACTIVITY.html Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. 9/10 Gene Ontology MF GO:0004065 5.86451214087109e-07 1.92595208502953e-06 900 484.090909090909 441 5.86451368853428e-08 126 2.09195248013193 -1.55133976245205 -1 11.538766580213 900 191 908 185 284 620 441 728 126 393 549 443 M18539 GO_CAMP_RESPONSE_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_RESPONSE_ELEMENT_BINDING.html Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. 14/16 Gene Ontology MF GO:0035497 4.27655951490693e-06 6.99387786154691e-06 285 422.363636363636 442 3.88778893463071e-07 147 1.49386142626463 -1.62617742106413 -1 7.41218091943318 285 520 515 442 553 315 147 361 708 501 299 444 M18753 GO_PROLINE_RICH_REGION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROLINE_RICH_REGION_BINDING.html Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. 25/26 Gene Ontology MF GO:0070064 2.75026616642882e-07 1.66268825097163e-06 295 407.363636363636 445 2.50024228204129e-08 114 1.2360421822646 -1.22185995879747 -1 6.87106113750726 593 114 571 481 116 445 294 292 348 630 597 445 M18882 GO_HYALURONIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONIC_ACID_BINDING.html Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. 14/24 Gene Ontology MF GO:0005540 5.53563792056444e-05 6.50754381501468e-05 445 503.090909090909 445 5.03252473921848e-06 216 2.57609473868334 3.09505747766367 1 10.4028904075438 362 445 216 654 775 421 444 597 701 399 520 446 M17994 GO_CYCLIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_BINDING.html Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. 18/22 Gene Ontology MF GO:0030332 1.04525346702092e-06 2.56865479661524e-06 720 517.181818181818 446 9.50230876033702e-08 153 1.91753429142443 -1.25285232227948 -1 10.3394121201251 718 434 418 323 361 613 446 886 153 532 805 447 M18585 GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_PHOSPHATE_GROUP_AS_ACCEPTOR.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). 36/44 Gene Ontology MF GO:0016776 9.69276386443722e-07 2.44987679802776e-06 560 491.090909090909 446 8.81160739534496e-08 300 1.61483360898531 1.9846402289357 1 8.73048698528328 557 411 446 596 347 561 568 790 300 383 443 448 M18021 GO_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 87/105 Gene Ontology MF GO:0019210 2.41401801100116e-07 1.65381926038186e-06 495 436.363636363636 448 2.19456206898799e-08 83 2.33626553488335 2.66379992974136 1 13.0428675983742 493 724 243 813 83 362 654 412 448 455 113 449 M18235 GO_ANTIOXIDANT_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIOXIDANT_ACTIVITY.html Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. 50/82 Gene Ontology MF GO:0016209 3.21255777097462e-05 3.96156475227655e-05 620 451 448 2.92054971220183e-06 166 1.83072643996977 -1.80628255002354 -1 7.7592089419437 255 618 448 616 741 316 166 167 611 645 378 450 M18727 GO_DNA_DEPENDENT_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction. 83/87 Gene Ontology MF GO:0008094 1.90935945386444e-05 2.50305723484635e-05 20 359.272727272727 448 1.73579638656197e-06 16 1.36644538616186 1.45662638937854 1 6.04129387677709 16 538 671 448 693 21 29 201 577 585 173 451 M18266 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a protein serine/threonine kinase. 23/25 Gene Ontology MF GO:0043539 7.43650443272899e-08 1.26752914920828e-06 770 456.090909090909 450 6.7604588037272e-09 5 1.77127786602967 -2.09596953628769 -1 10.0734072534862 770 117 331 235 5 904 754 532 571 450 348 452 M18269 GO_L_ASCORBIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_BINDING.html Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 18/21 Gene Ontology MF GO:0031418 3.41360447246497e-06 5.8956458552479e-06 450 464.181818181818 450 3.10328160832385e-07 180 1.63424006847159 2.12758256394151 1 8.2316166788883 450 431 436 592 527 598 890 180 258 458 286 453 M18024 GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING.html A DNA binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors. 35/51 Gene Ontology MF GO:0098531 8.03147822692489e-05 9.24247620730759e-05 150 390.363636363636 452 7.30161040439244e-06 70 1.52522412060839 -1.54962746739381 -1 5.91069564545167 149 669 498 452 793 151 221 70 734 484 73 454 M18214 GO_NEUROPEPTIDE_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_HORMONE_ACTIVITY.html The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. 9/29 Gene Ontology MF GO:0005184 4.18212315757988e-06 6.9005032100068e-06 300 475.272727272727 452 4.18213102817007e-07 177 3.42153192448608 2.71536890481875 1 17.069380656088 296 378 835 353 564 452 666 585 316 177 606 455 M18681 GO_GLUTATHIONE_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_TRANSFERASE_ACTIVITY.html Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. 23/38 Gene Ontology MF GO:0004364 3.60512305090183e-07 1.69370198541451e-06 770 454.727272727273 452 3.27738512879154e-08 113 2.07727456881274 1.52422592153382 1 11.5698398910663 767 116 343 354 167 555 894 521 113 452 720 456 M18861 GO_PHOSPHATIDIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_BINDING.html Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 18/19 Gene Ontology MF GO:0070300 2.0208798390833e-06 4.02298873906755e-06 650 438.090909090909 452 1.83716517766274e-07 41 2.87711217343443 3.30175475165717 1 14.9982037641138 647 684 287 234 452 552 688 129 41 680 425 457 M19047 GO_DEAMINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEAMINASE_ACTIVITY.html Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). 23/28 Gene Ontology MF GO:0019239 6.80452020480689e-07 2.01518482988512e-06 770 526.818181818182 453 6.18592937220111e-08 291 2.0171066255794 1.89199146855267 1 11.0854251870902 769 424 357 777 291 695 825 348 320 453 536 458 M17982 GO_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 159/232 Gene Ontology MF GO:0004713 5.30036381717383e-07 1.87024687461194e-06 635 471.727272727273 454 4.81851372197067e-08 106 2.20660436610564 2.32830283083906 1 12.2015486559907 632 281 106 273 242 668 916 677 454 144 796 459 M18832 GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 22/25 Gene Ontology MF GO:0005086 0.000539434360067416 0.000579578312444526 240 436.545454545455 454 4.90515157647169e-05 47 1.67169075367531 -1.31882214501325 -1 5.19108304492162 239 893 565 494 852 170 128 454 47 770 190 460 M19217 GO_SODIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_ACTIVITY.html Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. 19/37 Gene Ontology MF GO:0005272 3.71288325931797e-07 1.69915264086736e-06 525 373.454545454545 456 3.37534898721077e-08 65 3.39126047167549 3.81433360812772 1 18.919664647158 522 129 65 103 175 477 560 841 456 72 708 461 M19177 GO_STRUCTURAL_MOLECULE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_MOLECULE_ACTIVITY.html The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. 611/949 Gene Ontology MF GO:0005198 1.90483578070761e-07 1.65381926038186e-06 315 432.363636363636 457 1.90483594398559e-08 61 2.318434923522 2.59977765369799 1 12.9428902309615 311 604 921 457 61 405 556 493 269 209 470 462 M18352 GO_INTERLEUKIN_1_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the interleukin-1 receptor. 27/51 Gene Ontology MF GO:0005149 2.81906636127493e-06 5.10748493689811e-06 460 422.272727272727 458 2.56279088510507e-07 136 2.84447333597915 -2.943949763158 -1 14.5414596605951 458 671 259 412 501 646 490 136 189 548 335 463 M19192 GO_ARMADILLO_REPEAT_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARMADILLO_REPEAT_DOMAIN_BINDING.html Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. 17/19 Gene Ontology MF GO:0070016 1.21881046508831e-06 2.815452174354e-06 875 498 458 1.10801012755967e-07 23 1.43539360332506 -1.38132089560971 -1 7.66996682689089 872 148 458 155 383 782 742 450 23 662 803 464 M18580 GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 87/102 Gene Ontology MF GO:0004725 2.92947384599592e-07 1.67088508253101e-06 700 472.545454545455 460 2.66315839643508e-08 25 1.85687969880042 -1.52468371473778 -1 10.3468916880364 700 25 271 135 128 828 888 693 460 226 844 465 M17953 GO_MAGNESIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_BINDING.html Interacting selectively and non-covalently with magnesium (Mg) ions. 210/271 Gene Ontology MF GO:0000287 2.21141528396584e-06 4.31086017380683e-06 445 520.818181818182 462 2.01037955168979e-07 238 1.39821753712601 1.46839822816879 1 7.21896233538886 442 607 715 793 462 238 449 357 562 752 352 466 M18454 GO_OLIGOPEPTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOPEPTIDE_BINDING.html Interacting selectively and non-covalently with an oligopeptide. 13/20 Gene Ontology MF GO:1900750 1.90980016295095e-05 2.50305723484635e-05 490 443.454545454545 462 1.73619703814132e-06 256 1.82911411168964 1.3578246315348 1 8.10603859008615 268 363 447 478 694 256 575 489 490 462 356 467 M18726 GO_GABA_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_ACTIVITY.html Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. 3/22 Gene Ontology MF GO:0016917 5.31581352581521e-06 8.36765195545699e-06 565 464.181818181818 462 5.31582624190107e-07 18 2.99136156317017 2.06971074843582 1 14.6733217185942 561 220 875 312 593 462 406 796 18 253 610 468 M18426 GO_COPPER_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_BINDING.html Interacting selectively and non-covalently with copper (Cu) ions. 44/68 Gene Ontology MF GO:0005507 3.42770885536498e-05 4.19497083755926e-05 390 464.818181818182 463 3.11614751084537e-06 109 3.34288891910901 4.05588535319073 1 14.1344885486689 389 737 168 656 747 463 599 109 333 446 466 469 M18535 GO_LIGASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_REGULATOR_ACTIVITY.html Modulates the activity of a ligase. 15/20 Gene Ontology MF GO:0055103 2.78391999324485e-05 3.47613793751114e-05 230 486.090909090909 463 2.53086838372603e-06 155 1.46456585924572 -1.36535767878282 -1 6.27659194372224 229 696 463 785 731 205 155 425 740 686 232 470 M18644 GO_GABA_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABA_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. 13/25 Gene Ontology MF GO:0050811 1.2127760294771e-06 2.815452174354e-06 400 433 464 1.10252427094068e-07 122 1.28552037046329 -1.0942449509935 -1 6.86320294082958 399 590 501 545 381 264 273 480 744 464 122 471 M18746 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 14/23 Gene Ontology MF GO:0016638 7.93122941725927e-05 9.16056997693446e-05 795 489.727272727273 464 7.21046850980235e-06 222 2.90514819362415 3.28321025251472 1 11.3205202233764 415 515 222 464 791 582 795 286 493 398 426 472 M18492 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein receptor. 13/20 Gene Ontology MF GO:0050750 1.14000531427786e-05 1.58162899458369e-05 465 440.272727272727 465 1.03637383786229e-06 102 1.35778704434692 1.35077699031644 1 6.26518334125523 122 700 581 626 652 148 102 465 462 702 283 473 M18599 GO_CGMP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BINDING.html Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). 7/19 Gene Ontology MF GO:0030553 0.0118420020579328 0.0121442951182352 250 515.272727272727 466 0.00119055842972 246 2.38208350889172 2.40586982486382 1 4.36877648312663 246 599 870 421 895 466 665 402 311 285 508 474 M17870 GO_SIGNAL_TRANSDUCER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCER_ACTIVITY.html Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. 855/2441 Gene Ontology MF GO:0004871 8.32274744336923e-25 1.53804372753463e-22 130 426.636363636364 467 8.32274744336925e-26 4 2.24968683252108 2.46392596008037 1 47.5350779919701 569 229 801 127 126 467 874 595 395 4 506 475 M18059 GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ACTIVATED_POTASSIUM_CHANNEL_ACTIVITY.html Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. 8/19 Gene Ontology MF GO:0015269 5.61755869829072e-06 8.73842464178556e-06 875 498.090909090909 467 5.61757289897582e-07 3 3.70476993286752 -2.95812663492066 -1 18.1186283024769 875 201 817 102 598 895 912 394 3 215 467 476 M18135 GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED_TO_TRANSMEMBRANE_MOVEMENT_OF_IONS_PHOSPHORYLATIVE_MECHANISM.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. 30/45 Gene Ontology MF GO:0015662 2.99240098357477e-07 1.67574455080187e-06 865 447.363636363636 467 2.72036490054174e-08 99 2.11538194908469 -1.93025510199173 -1 11.7926249260533 862 99 201 123 132 697 751 575 467 114 900 477 M19099 GO_PURINERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_ACTIVITY.html Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 14/26 Gene Ontology MF GO:0035586 1.9704801043808e-06 3.97537907521366e-06 630 409.454545454545 467 1.79134715389854e-07 108 2.6991789899165 -2.34154614179099 -1 14.0806758406106 626 165 151 467 445 506 309 518 569 108 640 478 M19190 GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. 123/150 Gene Ontology MF GO:0001046 2.65494882086068e-06 4.85776774351537e-06 400 460.727272727273 467 2.41359274985894e-07 288 1.64021356973453 -1.39358692169874 -1 8.39568358994537 396 288 467 342 498 459 338 775 505 522 478 479 M17875 GO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_BINDING.html Interacting selectively and non-covalently with a SMAD signaling protein. 97/113 Gene Ontology MF GO:0046332 2.25269577647554e-06 4.34566622245621e-06 245 459.545454545455 468 2.04790734830236e-07 163 2.03469562634758 2.45228444294215 1 10.5240111439724 245 722 283 378 468 630 631 568 604 363 163 480 M18243 GO_MANGANESE_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_BINDING.html Interacting selectively and non-covalently with manganese (Mn) ions. 58/69 Gene Ontology MF GO:0030145 2.77450693706262e-07 1.66268825097163e-06 670 452.181818181818 468 2.52227935178792e-08 119 1.96185525399951 -1.47968725235577 -1 10.9391059723588 668 403 334 740 119 616 482 320 510 314 468 481 M18591 GO_PEPTIDE_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen peptide. 30/62 Gene Ontology MF GO:0042605 1.93970618355953e-05 2.53506154683027e-05 135 460.454545454545 468 1.763384805329e-06 94 1.19680599829592 -1.05523749963018 -1 5.27784235622253 131 94 508 620 697 307 574 468 828 424 414 482 M18865 GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. 42/52 Gene Ontology MF GO:0008375 7.24285721792178e-05 8.3969887946797e-05 350 493.363636363636 468 6.58463243529537e-06 133 2.04167083614141 2.02497280982171 1 8.01378481695568 350 795 406 811 788 133 267 528 531 468 350 483 M18915 GO_IRON_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_BINDING.html Interacting selectively and non-covalently with iron (Fe) ions. 109/229 Gene Ontology MF GO:0005506 6.33069711761257e-07 1.95615192380487e-06 645 455.454545454545 469 5.75518085393464e-08 107 2.39650299826748 -2.57158153709392 -1 13.2111554872968 645 289 107 576 273 469 419 872 512 118 730 484 M19183 GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_4_5_TRISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. 45/53 Gene Ontology MF GO:0005547 1.96175458412739e-06 3.96643596440636e-06 765 462.090909090909 471 1.78341484858103e-07 136 2.25215379370253 2.19433313847184 1 11.7414436884835 505 308 295 152 443 471 733 761 136 517 762 485 M17927 GO_DNA_BINDING_BENDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BINDING_BENDING.html The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. 14/24 Gene Ontology MF GO:0008301 2.2732481218302e-06 4.35784494724295e-06 475 405.727272727273 472 2.06659133706237e-07 22 1.99867867332125 -2.40802303894862 -1 10.3343614985999 779 163 289 98 472 633 697 475 22 214 621 486 M18188 GO_FAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAD_BINDING.html Interacting selectively and non-covalently with the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 13/15 Gene Ontology MF GO:0071949 5.37942387818857e-07 1.87024687461194e-06 505 427 472 4.89038653960164e-08 112 1.69170313538812 -1.38937024498986 -1 9.34113635998565 502 172 472 284 245 500 612 630 112 461 707 487 M18416 GO_RNA_POLYMERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_BINDING.html Interacting selectively and non-covalently with an RNA polymerase molecule or complex. 44/48 Gene Ontology MF GO:0070063 1.81677390280894e-06 3.71066783908768e-06 345 514.181818181818 475 1.65161400283095e-07 216 1.30689899191607 -1.68640406499528 -1 6.82630947060683 344 794 687 769 434 475 533 216 318 847 239 488 M18770 GO_TRANSCRIPTION_COACTIVATOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_BINDING.html Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 11/12 Gene Ontology MF GO:0001223 0.00031817138865167 0.000345464586503106 450 496.545454545455 475 2.89288557259463e-05 171 1.34522605478024 -1.39912821525598 -1 4.45940156173846 449 596 475 561 843 382 171 283 720 584 398 489 M19050 GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell. 165/201 Gene Ontology MF GO:0005057 1.9256982587277e-07 1.65381926038186e-06 895 554.181818181818 475 1.75063493389767e-08 50 1.71651139168808 1.85428112283134 1 9.56786685812731 898 278 394 196 50 894 786 879 475 355 891 490 M18717 GO_AU_RICH_ELEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AU_RICH_ELEMENT_BINDING.html Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases. 23/26 Gene Ontology MF GO:0017091 5.76744824753374e-06 8.94148016899525e-06 140 389.545454545455 478 5.24314851576677e-07 59 1.47840167211885 1.32958724639124 1 7.18191298595551 136 501 478 702 588 72 59 542 360 594 253 491 M18592 GO_DYNEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_BINDING.html Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules. 37/55 Gene Ontology MF GO:0045502 2.13608185325923e-06 4.20840006910773e-06 460 507.727272727273 479 1.94189447934801e-07 308 1.90120385990763 -2.01717629026314 -1 9.85553517906647 587 627 460 622 457 664 466 308 479 526 389 492 M17884 GO_NEUROTRANSMITTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BINDING.html Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 11/32 Gene Ontology MF GO:0042165 7.02743951116101e-06 1.04900712573712e-05 605 507.818181818182 480 6.38860178085997e-07 307 1.97141194446293 -2.44271119868598 -1 9.46318934541222 602 453 313 326 613 681 731 656 307 480 424 493 M17892 GO_PROTEIN_COMPLEX_SCAFFOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SCAFFOLD.html Functions to provide a physical support for the assembly of a multiprotein complex. 74/90 Gene Ontology MF GO:0032947 5.01474392017692e-07 1.84352199509307e-06 840 507.636363636364 482 4.55885914841145e-08 114 2.02763645340536 2.37737944370638 1 11.2196261991324 838 482 303 228 231 672 893 459 114 538 826 494 M18516 GO_HMG_BOX_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HMG_BOX_DOMAIN_BINDING.html Interacting selectively and non-covalently with an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. 9/22 Gene Ontology MF GO:0071837 8.31782392768182e-06 1.20843857062547e-05 380 479.909090909091 482 8.31785506163353e-07 161 2.15785758699978 2.85942721872766 1 10.2349405383014 479 376 865 161 635 533 712 376 482 178 482 495 M18368 GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a protein serine/threonine kinase. 33/35 Gene Ontology MF GO:0030291 6.54804697646459e-07 1.96441409293938e-06 710 491.545454545455 483 5.95277175037843e-08 95 2.02770550702141 1.79982581978904 1 11.1657642615407 706 553 363 476 288 749 663 483 95 431 600 496 M18728 GO_METALLOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 131/200 Gene Ontology MF GO:0008237 8.39049699710203e-07 2.26793305838056e-06 585 508.636363636364 484 7.62772745193068e-08 143 2.19433379096624 2.65585217887069 1 11.9551918787039 583 479 143 649 325 677 859 467 484 362 567 497 M18965 GO_ANTIGEN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_BINDING.html Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. 71/315 Gene Ontology MF GO:0003823 2.43452202220684e-06 4.55364038161766e-06 485 482.454545454545 484 2.21320428750484e-07 252 2.02042936500194 -1.7989299245161 -1 10.4100425870766 469 540 252 619 484 481 650 602 547 291 372 498 M18163 GO_METALLOEXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLOEXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. 35/53 Gene Ontology MF GO:0008235 3.06081359593873e-07 1.6834474777663e-06 415 556.090909090909 485 2.78255820162122e-08 136 2.02750647033009 -1.46779522180179 -1 11.2964725641517 749 412 324 413 136 771 703 864 384 485 876 499 M17933 GO_STEROID_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_DEHYDROGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. 23/53 Gene Ontology MF GO:0016229 1.88677112801407e-05 2.48344233943732e-05 270 501.909090909091 487 1.71526119054185e-06 267 1.62988715637993 -1.91854543488372 -1 7.22235227725904 267 503 487 750 691 363 358 440 745 518 399 500 M18240 GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other. 13/17 Gene Ontology MF GO:0042887 0.000143829626762305 0.000160311912096948 380 540.818181818182 487 1.30762755261255e-05 288 2.50585350271405 -1.64198731176771 -1 9.16613430619826 380 701 337 664 823 487 452 407 858 552 288 501 M18365 GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. 7/13 Gene Ontology MF GO:0004859 1.05868568456944e-05 1.49347415655292e-05 395 504.454545454545 487 1.05869072827246e-06 212 1.26235018345732 -1.35427443379588 -1 5.85131847953685 395 212 849 487 655 522 570 605 437 405 412 502 M18823 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH2_GROUP_OF_DONORS_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. 13/20 Gene Ontology MF GO:0016641 9.23562710203624e-05 0.000105291338103747 470 521 487 8.39637712507999e-06 194 2.90514819362415 3.28321025251472 1 11.1501462076476 470 519 194 579 802 658 922 301 487 360 439 503 M17995 GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NUCLEOTIDE_RECEPTOR_ACTIVITY.html Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 6/15 Gene Ontology MF GO:0001608 7.49783616170251e-07 2.1316924964348e-06 640 467.636363636364 488 7.49783869149332e-08 201 4.6328329806499 -3.76720577357142 -1 25.4245692444253 638 214 811 261 320 610 488 540 398 201 663 504 M18035 GO_GUANYLATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYLATE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + GMP = ADP + GDP. 14/16 Gene Ontology MF GO:0004385 3.79811592246547e-05 4.61164140914335e-05 760 545 488 3.45289226849438e-06 300 1.96479707190201 2.37530226530099 1 8.20585499907393 757 514 346 374 753 796 917 300 445 305 488 505 M18180 GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_DEHYDROGENASE_NAD_ACTIVITY.html Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. 19/21 Gene Ontology MF GO:0004029 2.22002722306125e-05 2.84114287272659e-05 435 477.090909090909 488 2.01822693249577e-06 229 2.26440392569567 1.74553975368346 1 9.92776655366584 433 571 280 417 712 275 229 504 650 488 689 506 M18456 GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. 172/211 Gene Ontology MF GO:0004721 3.24346851007088e-07 1.69329794462269e-06 820 506.363636363636 490 2.94860817114254e-08 146 1.82234466516016 2.09534845732378 1 10.1431735494682 817 277 420 308 146 510 734 866 346 490 656 507 M19073 GO_RECEPTOR_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_REGULATOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. 34/55 Gene Ontology MF GO:0030545 1.30310511888405e-06 2.92960858844005e-06 495 451.727272727273 490 1.18464171885507e-07 176 2.24893372027699 -2.57387349885938 -1 12.0115845331033 495 490 258 373 396 651 596 242 746 176 546 508 M17938 GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 2/14 Gene Ontology MF GO:0099528 0.010502469028977 0.0107945287906282 910 536.5 491.5 0.00117242430312518 88 1.72442865499507 -1.72442865499507 -1 3.23254213472983 263 649 807 NA 907 404 88 374 910 579 384 509 M17895 GO_OXALATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. 6/11 Gene Ontology MF GO:0019531 0.000549712924960685 0.00058925144160519 320 554.181818181818 492 5.49848955257168e-05 226 1.71624802941838 -1.73455647400617 -1 5.31899307927699 320 833 803 757 856 299 285 226 821 492 404 510 M18280 GO_POLY_PURINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PURINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule. 24/29 Gene Ontology MF GO:0070717 0.00200457786573653 0.00210241764805966 215 536.545454545455 492 0.000182400610350095 212 1.40289965107705 1.7555141712605 1 3.58590488147971 212 679 628 606 874 439 330 429 464 749 492 511 M18340 GO_LYSOZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOZYME_ACTIVITY.html Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. 2/15 Gene Ontology MF GO:0003796 0.000256547135756778 0.000280200417776906 565 491.5 492 2.85084880256243e-05 25 4.17583981778122 -6.46517573491148 -1 14.3304617977566 562 531 846 NA 855 685 322 288 453 348 25 512 M18049 GO_POLY_A_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_BINDING.html Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. 17/22 Gene Ontology MF GO:0008143 0.0118037610624601 0.0121185280241257 275 534.181818181818 494 0.00107887019613892 259 1.76082955827786 2.17634430967842 1 3.21616971717025 273 901 599 502 893 446 259 451 352 706 494 513 M18913 GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_AMINE_RECEPTOR_ACTIVITY.html Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. 10/62 Gene Ontology MF GO:0008227 3.76494123277158e-05 4.57737591984335e-05 875 544 494 3.4227324228589e-06 205 2.7744930733683 2.54125030946596 1 11.619591116703 871 461 205 396 752 725 806 494 378 224 672 514 M17903 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase. 29/30 Gene Ontology MF GO:0031434 9.35139414580968e-06 1.33964157995785e-05 480 497.636363636364 495 8.50130354127032e-07 301 1.27295367460325 -1.29637182432682 -1 5.95922655214376 478 326 558 564 638 495 431 347 805 531 301 515 M18212 GO_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_ACTIVITY.html Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 13/14 Gene Ontology MF GO:0004707 8.77692471104622e-05 0.000100494156542834 255 459.181818181818 495 7.97934080636546e-06 57 1.42084078909045 -1.47835740782504 -1 5.45220482443488 251 521 531 666 799 423 456 210 495 642 57 516 M19015 GO_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. 6/13 Gene Ontology MF GO:0015116 0.000549712924960685 0.00058925144160519 325 564.181818181818 495 5.49848955257168e-05 223 1.71624802941838 -1.73455647400617 -1 5.31899307927699 321 834 905 758 857 300 286 223 822 495 405 517 M18020 GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_BINDING_INVOLVED_IN_PROTEIN_FOLDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding. 18/22 Gene Ontology MF GO:0044183 0.00167600025526418 0.00175980026802739 185 504.090909090909 496 0.000152479856941956 80 1.54430199804297 1.73848991841009 1 4.06876190807651 185 759 556 440 873 241 80 496 852 771 292 518 M17889 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. 22/26 Gene Ontology MF GO:0080025 4.11556283622589e-05 4.95799225641815e-05 500 480.727272727273 499 3.741490753185e-06 46 2.24599880590376 2.31598426992701 1 9.31988882639272 499 746 443 164 759 528 670 341 46 728 364 519 M18414 GO_STEROL_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORTER_ACTIVITY.html Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 14/25 Gene Ontology MF GO:0015248 9.29532667836616e-06 1.33563480330542e-05 590 421.818181818182 500 8.45033268430359e-07 37 2.80327899080522 -1.16576731290643 -1 13.1950431381872 807 586 315 230 636 587 186 190 37 500 566 520 M18357 GO_IMMUNOGLOBULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule. 9/121 Gene Ontology MF GO:0034987 6.31201931085383e-07 1.95615192380487e-06 605 485.818181818182 501 6.312021103726e-08 118 2.78340467380889 2.72623262095004 1 15.3531781529776 605 199 848 118 292 842 691 828 501 279 141 521 M18771 GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_REGULATOR_ACTIVITY.html Modulation of the activity of the enzyme protein phosphatase type 2A. 20/22 Gene Ontology MF GO:0008601 4.63835282910755e-06 7.45363132886152e-06 620 505.454545454545 502 4.21669328033764e-07 119 1.05662372847235 1.39069739913447 1 5.19777699065478 618 573 654 381 565 480 502 449 119 799 420 522 M18906 GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_KINASE_KINASE_BINDING.html Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase. 27/30 Gene Ontology MF GO:0031435 1.45702289578022e-06 3.17521027287955e-06 550 533.181818181818 502 1.32456714612983e-07 330 0.984380168122491 -1.14328021004882 -1 5.1923152967865 546 330 636 438 408 649 764 502 471 780 341 523 M18234 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORTER_ACTIVITY.html Enables the directed movement of carbohydrate derivative into, out of or within a cell, or between cells. 34/39 Gene Ontology MF GO:1901505 6.16846228177955e-07 1.95615192380487e-06 825 540.727272727273 503 5.60769455574759e-08 91 1.647326730487 -1.90043251406618 -1 9.06345428147925 824 91 459 742 269 887 672 241 503 467 793 524 M18405 GO_NUCLEOSIDE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. 12/14 Gene Ontology MF GO:0019206 0.000151744848322517 0.000168524326742795 370 519.363636363636 503 1.37959378112531e-05 181 1.33342471708474 1.46661753997704 1 4.82292316790311 538 367 503 658 826 385 181 905 370 516 464 525 M18651 GO_LIPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 14/21 Gene Ontology MF GO:0060229 2.06445309774918e-05 2.66790861862971e-05 120 407.181818181818 503 1.87679315507192e-06 75 1.33693206234987 -1.45873999290159 -1 5.87366939222504 117 592 549 503 705 98 75 171 798 719 152 526 M19090 GO_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. 391/476 Gene Ontology MF GO:0016887 1.64408205727962e-06 3.42919146935974e-06 715 538.363636363636 503 1.4946211690181e-07 326 1.71815158570703 1.94444284332467 1 9.04933735628217 503 713 660 565 426 326 450 676 394 712 497 527 M18045 GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_MONOPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. 13/13 Gene Ontology MF GO:0052744 5.64844738820778e-05 6.63172221944599e-05 105 402.454545454545 504 5.13508401450607e-06 69 0.953367273592124 -0.953367273592124 -1 3.8066064753628 105 595 629 504 778 81 69 106 697 765 98 528 M18043 GO_DNA_N_GLYCOSYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_N_GLYCOSYLASE_ACTIVITY.html Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. 15/17 Gene Ontology MF GO:0019104 0.000201768520769466 0.000222475075406905 265 522.636363636364 505 1.83442752668068e-05 187 1.99491587416807 1.71224650213167 1 7.01027468224657 264 762 505 719 832 224 187 409 755 608 484 529 M18782 GO_NADP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_BINDING.html Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. 40/65 Gene Ontology MF GO:0050661 5.24225025181751e-06 8.28006706440919e-06 330 551.363636363636 507 4.76569340300739e-07 329 1.64386342123171 -1.71907543464667 -1 8.04526560086143 329 664 471 701 578 570 499 507 816 478 452 530 M18867 GO_NF_KAPPAB_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NF_KAPPAB_BINDING.html Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. 37/42 Gene Ontology MF GO:0051059 4.19645562890114e-06 6.91180927113129e-06 185 448.545454545455 507 3.81496693961545e-07 152 1.2039052355629 -1.14888720957903 -1 5.96846392738116 182 666 673 507 549 166 152 362 634 806 237 531 M18131 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol phosphate. 140/175 Gene Ontology MF GO:1901981 2.9149032367317e-07 1.67088508253101e-06 800 490.272727272727 509 2.64991238449421e-08 127 2.04239832119725 -2.05479723002993 -1 11.3863041720658 799 285 292 156 127 878 757 509 265 586 739 532 M18497 GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_SIGNALING_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 87/96 Gene Ontology MF GO:0004702 2.18612587427668e-07 1.65381926038186e-06 350 484.272727272727 509 1.98738735591876e-08 68 1.40648718028951 -1.53528027169794 -1 7.82954146581916 349 297 610 631 68 483 496 640 556 688 509 533 M18512 GO_OMEGA_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OMEGA_PEPTIDASE_ACTIVITY.html Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). 14/15 Gene Ontology MF GO:0008242 1.28511808240639e-05 1.75658152092234e-05 475 515.272727272727 509 1.16829599037768e-06 96 2.29178610961292 2.38988459669081 1 10.5126446365491 766 588 329 474 666 509 472 96 658 397 713 534 M18031 GO_ESTROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an estrogen receptor. 50/56 Gene Ontology MF GO:0030331 9.65289390031997e-06 1.3782475887797e-05 380 561.090909090909 510 8.77539659489131e-07 376 1.32305111330335 -1.23494653290933 -1 6.18015376029898 376 792 686 454 640 434 388 413 693 786 510 535 M19079 GO_SODIUM_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_BINDING.html Interacting selectively and non-covalently with sodium ions (Na+). 12/30 Gene Ontology MF GO:0031402 7.60738171698615e-06 1.11398109453173e-05 625 478.636363636364 511 6.91582547516788e-07 110 3.75444682499136 -3.8260979576374 -1 17.9783986237985 755 446 110 197 624 779 622 836 163 222 511 536 M18370 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS_DISULFIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. 11/13 Gene Ontology MF GO:0016671 1.05367346430784e-07 1.5319595856108e-06 740 498.727272727273 512 9.57885013429762e-09 14 1.38314141607828 -0.839199595816907 -1 7.74322964969369 736 457 512 483 14 890 740 439 108 582 525 537 M17959 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. 94/142 Gene Ontology MF GO:0016616 1.36507983750976e-06 3.01034312615519e-06 490 556.727272727273 513 1.24098244048184e-07 402 1.6220285525352 -1.820917698209 -1 8.6288918898982 488 480 513 535 402 827 840 438 536 575 490 538 M18858 GO_GTP_RHO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_RHO_BINDING.html Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. 20/21 Gene Ontology MF GO:0017049 8.46020000429957e-05 9.69879007937072e-05 135 427.727272727273 513 7.691386693321e-06 133 1.51058944722451 -1.52703907331567 -1 5.82277619500938 133 572 542 704 798 202 167 302 550 513 222 539 M18905 GO_3_5_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. 49/52 Gene Ontology MF GO:0008408 3.66602161345132e-07 1.69370198541451e-06 470 543.545454545455 515 3.33274747667961e-08 174 0.887041633447285 0.952125487270359 1 4.90807442044404 467 736 754 731 174 231 223 443 827 878 515 540 M18011 GO_DIACYLGLYCEROL_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_KINASE_ACTIVITY.html Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. 9/11 Gene Ontology MF GO:0004143 1.70665147395749e-05 2.26572695680563e-05 695 581.454545454545 517 1.7066645810658e-06 380 1.6707949960154 -0.998115922208966 -1 7.46961316115701 695 467 813 536 690 517 458 842 380 507 491 541 M18845 GO_EXOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. 75/104 Gene Ontology MF GO:0008238 1.47555474763197e-07 1.63698248897436e-06 850 510.909090909091 517 1.34141349690766e-08 31 1.85625718346288 -1.64580762483416 -1 10.3594306853325 848 38 365 517 31 862 781 524 480 475 699 542 M18487 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. 57/74 Gene Ontology MF GO:0098811 3.5218695025061e-07 1.69370198541451e-06 165 410.090909090909 521 3.20170006027693e-08 56 1.83399279772178 -1.6372424320363 -1 10.2081853324249 642 56 330 162 164 691 521 582 538 179 646 543 M18069 GO_MANNOSIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSIDASE_ACTIVITY.html Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. 15/15 Gene Ontology MF GO:0015923 7.28899708796654e-06 1.07760560395503e-05 465 458.090909090909 522 6.62638294349231e-07 63 1.46335765872819 -1.52594597846397 -1 6.9932266291673 465 164 522 274 617 622 554 604 63 683 471 544 M18197 GO_PHOSPHATASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVATOR_ACTIVITY.html Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 11/11 Gene Ontology MF GO:0019211 5.29095819780636e-07 1.87024687461194e-06 765 495.181818181818 523 4.8099631547929e-08 75 1.73863930494332 1.94915403269992 1 9.60187917533299 763 182 358 120 241 742 869 523 75 676 898 545 M18620 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. 48/54 Gene Ontology MF GO:0004520 3.2682042180342e-06 5.68704462799172e-06 525 451.909090909091 523 2.97109915737863e-07 100 1.45385791301416 1.48203647488279 1 7.33883557384987 259 620 630 632 521 100 127 577 695 523 287 546 M18869 GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOACTIVE_LIPID_RECEPTOR_ACTIVITY.html Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. 8/14 Gene Ontology MF GO:0045125 1.75880286479697e-05 2.3316124061297e-05 395 519.909090909091 523 1.75881678519586e-06 242 2.71286440213071 3.14388055085858 1 12.1310106091252 394 645 889 589 696 242 257 315 523 334 835 547 M19203 GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. 12/13 Gene Ontology MF GO:0046030 1.70074227914272e-05 2.26438885580386e-05 550 453.272727272727 523 1.54614129738432e-06 217 1.03457885945366 -1.20211252724565 -1 4.60394423831321 217 523 548 549 685 289 296 256 594 747 282 548 M17917 GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 143/194 Gene Ontology MF GO:0008234 0.000203235527613263 0.000223825539350006 210 604.454545454545 524 1.84776640814734e-05 210 1.5774442243282 -1.77615526993528 -1 5.52735915108056 210 847 704 900 833 482 414 469 524 880 386 549 M18741 GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the directed movement of water (H2O) from one side of a membrane to the other. 7/14 Gene Ontology MF GO:0005372 1.1221479708962e-06 2.67923701578317e-06 720 517.636363636364 525 1.12214853754383e-07 260 4.44740727754811 5.23184906695959 1 23.9764553051381 525 382 878 260 387 568 539 717 717 287 434 550 M18277 GO_GAMMA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin. 35/46 Gene Ontology MF GO:0043015 9.07798118507577e-07 2.34959513025491e-06 660 532.818181818182 526 8.25271357361393e-08 320 1.63365572906673 1.81863595181004 1 8.86166671393494 658 320 419 434 341 656 655 526 625 486 741 551 M18474 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor. 10/10 Gene Ontology MF GO:0016723 5.66272434050148e-06 8.79387779936701e-06 530 475 526 5.14794446928338e-07 228 1.19317638846124 -1.3031195129121 -1 5.7937419532714 338 526 529 550 587 378 443 228 787 544 315 552 M18176 GO_INSULIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin receptor. 35/46 Gene Ontology MF GO:0005158 1.91434949150797e-07 1.65381926038186e-06 670 535.272727272727 527 1.740317870988e-08 48 1.85047720611421 -1.35437465370052 -1 10.3190216659006 666 667 417 495 48 380 527 466 789 649 784 553 M18616 GO_METAL_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_CLUSTER_BINDING.html Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. 64/69 Gene Ontology MF GO:0051540 1.20945537550079e-06 2.815452174354e-06 475 587.818181818182 527 1.09950549127487e-07 379 1.42118507062558 1.3708679650194 1 7.59348264864919 472 732 670 787 379 523 445 481 527 767 683 554 M18468 GO_FIBRONECTIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRONECTIN_BINDING.html Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. 29/46 Gene Ontology MF GO:0001968 2.85241403774866e-05 3.54251420817172e-05 530 479.545454545455 530 2.59313729222412e-06 38 2.59947995919012 2.97028094888266 1 11.1636621710427 530 492 130 583 813 631 858 38 570 169 461 555 M18736 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 93/149 Gene Ontology MF GO:0001078 4.11898544816772e-07 1.70429971387201e-06 385 561.727272727273 530 3.74453292668329e-08 160 1.79612347766003 -1.43374080538784 -1 9.99151089972038 382 853 421 867 193 305 160 904 739 530 825 556 M18780 GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. 26/29 Gene Ontology MF GO:0015605 3.39353152730104e-07 1.69370198541451e-06 925 520.636363636364 530 3.08502913705296e-08 107 1.50683108679909 1.47191134847413 1 8.37705251432208 924 107 455 530 156 687 480 596 637 250 905 557 M18922 GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_BETA_GAMMA_SUBUNIT_COMPLEX_BINDING.html Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits. 18/24 Gene Ontology MF GO:0031683 1.25530792208191e-06 2.87105079208833e-06 545 429 530 1.14118967123117e-07 126 1.8622250078478 2.28134877530787 1 9.95225151193921 545 574 370 591 389 530 679 164 215 536 126 558 M17964 GO_CARBOHYDRATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BINDING.html Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. 183/328 Gene Ontology MF GO:0030246 1.06638669012712e-06 2.60506436363068e-06 610 460.272727272727 532 9.69442915479758e-08 118 2.1741626416439 2.55929365826695 1 11.7178632967594 609 272 118 647 363 556 913 212 616 225 532 559 M18471 GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_OXIDIZING_METAL_IONS.html Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. 15/22 Gene Ontology MF GO:0016722 4.14123897760848e-06 6.84683769481148e-06 535 550.727272727273 534 3.7647697936546e-07 433 1.3933032238455 -1.52047125270993 -1 6.92188663047157 474 511 502 534 548 534 591 753 614 433 564 560 M17896 GO_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTPASE_ACTIVITY.html Catalysis of the reaction: GTP + H2O = GDP + phosphate. 232/266 Gene Ontology MF GO:0003924 3.92481111399914e-07 1.70429971387201e-06 495 603.727272727273 535 3.56801074017054e-08 184 1.39534572219454 -1.28151896807963 -1 7.74940005512748 492 921 749 890 184 485 413 535 596 858 518 561 M18690 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 181/280 Gene Ontology MF GO:0001077 6.23956179246254e-07 1.95615192380487e-06 625 485.545454545455 535 5.67233051100506e-08 238 2.09085141241591 -1.82551960178117 -1 11.5189616662719 624 608 238 328 272 736 714 447 535 289 550 562 M18896 GO_K63_LINKED_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_K63_LINKED_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers. 18/19 Gene Ontology MF GO:0070530 1.39156744004358e-06 3.0585416993859e-06 665 570.181818181818 535 1.26506210932129e-07 334 1.5278536698786 -1.71678710080061 -1 8.1143839675018 664 505 517 488 404 734 581 691 334 535 819 563 M18428 GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_GLYCOSYL_BONDS.html Catalysis of the hydrolysis of any glycosyl bond. 93/134 Gene Ontology MF GO:0016798 1.15400782856166e-06 2.73411085536148e-06 680 595.090909090909 536 1.04909857626889e-07 324 1.90353422822017 -1.67377857400459 -1 10.2134607542746 678 536 469 689 372 909 903 511 324 626 529 564 M18561 GO_LRR_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LRR_DOMAIN_BINDING.html Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein. 21/25 Gene Ontology MF GO:0030275 1.44091122527538e-05 1.94649411133691e-05 330 509.363636363636 536 1.30992787522636e-06 166 1.53080498064387 1.74933198185946 1 6.93692518582636 327 680 536 821 673 376 454 166 601 713 256 565 M18826 GO_HSP70_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP70_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size. 31/36 Gene Ontology MF GO:0030544 3.86047874212126e-06 6.54510524352302e-06 710 540.909090909091 536 3.5095322876031e-07 217 1.06452228994392 1.23067785308979 1 5.29533625442129 326 806 706 841 536 221 308 414 866 709 217 566 M17988 GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_AMINO_ACID_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). 9/19 Gene Ontology MF GO:0005283 2.024556021284e-06 4.02298873906755e-06 790 531.818181818182 537 2.02455786575855e-07 229 3.24520866551276 1.91276754848978 1 16.9243243851601 568 466 810 229 464 571 537 788 239 389 789 567 M17993 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 24/39 Gene Ontology MF GO:0001205 3.88309312222388e-06 6.54740519148698e-06 865 592.909090909091 538 3.5300908873314e-07 399 1.70021869239468 -1.39268106486985 -1 8.49115084778114 863 420 399 492 538 729 485 801 679 402 714 568 M19143 GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. 17/30 Gene Ontology MF GO:0070001 1.56267804863557e-05 2.09262973469459e-05 60 412.272727272727 538 1.42062649870576e-06 58 1.36079837629985 -1.38595426907001 -1 6.1187401684929 58 689 538 712 681 102 79 296 654 661 65 569 M18027 GO_CARBOXY_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_LYASE_ACTIVITY.html Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. 29/37 Gene Ontology MF GO:0016831 7.33908995515995e-07 2.10958918882098e-06 580 513.454545454545 539 6.67190218494982e-08 303 1.56791990545645 -1.78836465454518 -1 8.57396150908299 577 494 519 661 303 541 350 539 704 650 310 570 M18827 GO_SNRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_BINDING.html Interacting selectively and non-covalently with a small nuclear RNA (snRNA). 37/42 Gene Ontology MF GO:0017069 1.01863797596779e-05 1.44138053567264e-05 60 434.727272727273 539 9.26038811334568e-07 38 1.23553328914683 1.33233956082985 1 5.74428622897336 56 628 677 752 646 121 38 297 539 805 223 571 M18121 GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. 234/368 Gene Ontology MF GO:0001228 3.56687751539727e-07 1.69370198541451e-06 660 486.909090909091 541 3.24261644881644e-08 166 2.11201469886277 -1.92850864563261 -1 11.7642813251215 660 606 206 405 166 757 674 541 521 238 582 572 M18178 GO_CIS_TRANS_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_TRANS_ISOMERASE_ACTIVITY.html Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. 36/44 Gene Ontology MF GO:0016859 0.000200007448116594 0.000220796752759538 175 479.909090909091 541 1.81841485094226e-05 172 1.49445410633777 1.57337321484147 1 5.24215373804632 172 629 541 815 831 194 230 273 592 697 305 573 M18952 GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription. 64/83 Gene Ontology MF GO:0070491 5.13402162140733e-06 8.13693992826823e-06 210 432.727272727273 541 4.66730327494226e-07 82 1.1008224663286 1.07920103212409 1 5.37690492379522 209 541 703 570 576 82 148 258 681 737 255 574 M18374 GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_DIOXYGENASE_ACTIVITY.html Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. 10/12 Gene Ontology MF GO:0031543 9.24148000023146e-05 0.000105291338103747 375 493.545454545455 542 8.40169838853914e-06 76 1.77191611601903 2.24749392026732 1 6.77860271093012 375 829 440 595 860 597 753 76 246 542 116 575 M18450 GO_LAMIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMIN_BINDING.html Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. 27/29 Gene Ontology MF GO:0005521 3.99919701389038e-06 6.69430804499041e-06 360 447.181818181818 542 3.63564025792408e-07 35 1.28953593036923 1.63790519632912 1 6.41438617099613 356 673 648 720 542 294 252 35 549 779 71 576 M18642 GO_ORGANIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BINDING.html Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage. 172/287 Gene Ontology MF GO:0043177 1.55850089945263e-06 3.32164309585458e-06 625 514.818181818182 543 1.41682000319143e-07 132 2.16323420586195 2.0793734028415 1 11.4372709406219 625 477 132 659 417 408 745 543 671 265 721 577 M19144 GO_RNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. 42/44 Gene Ontology MF GO:0034062 2.27152319611574e-06 4.35784494724295e-06 880 614.909090909091 543 2.06502321953708e-07 283 0.807891805531547 0.882820025299794 1 4.14348897632057 283 880 773 877 471 392 347 418 884 896 543 578 M19210 GO_HEXOSAMINIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSAMINIDASE_ACTIVITY.html Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. 15/18 Gene Ontology MF GO:0015929 5.04192509616198e-07 1.84352199509307e-06 595 517.727272727273 543 4.58356931969339e-08 233 1.27651843820069 -1.16935678110507 -1 7.04241400669706 595 354 543 540 233 766 609 245 675 611 524 579 M17924 GO_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. 177/237 Gene Ontology MF GO:0042393 4.06159629879015e-06 6.7620089731209e-06 335 617.636363636364 545 3.69236708840722e-07 332 1.1050273420627 1.15650614078799 1 5.4838078359469 409 924 787 914 545 332 507 332 764 898 382 580 M18130 GO_ATPASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_REGULATOR_ACTIVITY.html Modulates the rate of ATP hydrolysis by an ATPase. 40/45 Gene Ontology MF GO:0060590 2.97074500057194e-07 1.67574455080187e-06 405 493.545454545455 545 2.70067763793017e-08 130 1.41920615156176 1.32448618377757 1 7.89298494471019 404 545 563 497 130 435 582 610 597 415 651 581 M17868 GO_IMMUNOGLOBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_BINDING.html Interacting selectively and non-covalently with an immunoglobulin. 4/24 Gene Ontology MF GO:0019865 0.00832614004600446 0.00859592558939455 850 577.909090909091 546 0.000835750162296927 126 2.52702239533688 1.3734372787755 1 5.0058590026049 847 602 800 528 901 443 126 352 546 524 688 582 M18038 GO_ADENYLYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an adenylyl group to an acceptor. 30/34 Gene Ontology MF GO:0070566 2.29575096813288e-05 2.91784579718677e-05 135 460.181818181818 546 2.08706811379645e-06 132 1.48374876503909 -1.66693841581068 -1 6.46895804915292 132 557 546 864 715 154 258 404 574 670 188 583 M18204 GO_NADPH_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADPH_BINDING.html Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. 12/16 Gene Ontology MF GO:0070402 4.29304479437903e-05 5.15165375325483e-05 525 538 546 3.90284415496079e-06 193 1.13838895028115 1.58837969891991 1 4.67746003923533 570 522 525 546 763 624 687 428 193 615 445 584 M18904 GO_TETRAPYRROLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BINDING.html Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. 76/185 Gene Ontology MF GO:0046906 6.43582451121949e-07 1.95615192380487e-06 550 458 546 5.85075126721831e-08 188 2.18088484558807 -2.12413303425449 -1 12.017418164952 547 399 188 613 283 546 546 325 622 241 728 585 M18317 GO_SNAP_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNAP_RECEPTOR_ACTIVITY.html Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. 34/39 Gene Ontology MF GO:0005484 4.11752198190954e-06 6.83050325185712e-06 50 462.545454545455 547 3.74320880753416e-07 46 0.995815619215955 -0.891537872041641 -1 4.93200083799964 154 630 719 872 547 46 119 355 820 778 48 586 M18714 GO_STEROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a steroid hormone receptor. 101/118 Gene Ontology MF GO:0035258 3.18398614706243e-06 5.5825487663865e-06 725 535.181818181818 547 2.89453705013458e-07 294 1.30719684566357 -1.18934850624476 -1 6.6030033857211 455 721 721 294 518 401 297 588 595 750 547 587 M18065 GO_PEPTIDE_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for peptide hormones. 18/24 Gene Ontology MF GO:0051428 6.25764568402644e-06 9.4943589688677e-06 720 506.909090909091 548 5.68878498477008e-07 138 2.20676453211743 -0.850069008700163 -1 10.692399602448 716 577 309 202 599 829 548 848 277 533 138 588 M18402 GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 38/46 Gene Ontology MF GO:0008138 5.7030425979171e-07 1.88874959156824e-06 370 514.363636363636 548 5.18458552392079e-08 208 1.45584153782847 -1.30630318659234 -1 8.02482634612224 366 548 591 778 259 640 812 208 610 539 307 589 M18446 GO_LIPASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. 8/19 Gene Ontology MF GO:0055102 0.000123014681554743 0.000137943647762843 550 599.818181818182 549 1.23021491760672e-05 379 1.26235018345732 -1.35427443379588 -1 4.66928995506638 549 379 858 663 821 653 707 549 470 470 479 590 M19136 GO_DNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. 58/60 Gene Ontology MF GO:0003678 3.15599635900092e-05 3.89858373758937e-05 60 397.545454545455 549 2.86912875823663e-06 54 1.34536382657466 1.58211745579791 1 5.69612879240922 54 617 662 563 740 56 57 227 628 549 220 591 M18393 GO_SH2_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SH2_DOMAIN_BINDING.html Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. 34/52 Gene Ontology MF GO:0042169 7.42667095553139e-05 8.59930321166793e-05 700 551 550 6.75174697630252e-06 294 2.22149498187956 2.346827722619 1 8.70233390444358 696 741 413 334 789 550 321 529 294 573 821 592 M18874 GO_RAC_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_GTPASE_BINDING.html Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases. 49/56 Gene Ontology MF GO:0048365 2.0032241402075e-07 1.65381926038186e-06 740 519.090909090909 550 1.82111302055671e-08 54 1.34705732908447 1.53729933941263 1 7.49631452543034 737 305 550 375 54 678 799 638 481 388 705 593 M19195 GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAB_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY.html Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 30/30 Gene Ontology MF GO:0017112 2.3626675553046e-06 4.47720935793015e-06 220 478.181818181818 550 2.1478819024283e-07 216 1.20673187197942 -1.19081587354321 -1 6.20331452115835 216 556 607 660 478 278 303 550 620 671 321 594 M18110 GO_RHO_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_GTPASE_BINDING.html Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. 96/106 Gene Ontology MF GO:0017048 3.73667178571429e-07 1.70082991625616e-06 805 558 551 3.39697492762122e-08 178 1.4631177537803 1.74131611530143 1 8.12979977891068 802 396 595 431 178 756 854 551 520 386 669 595 M18263 GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_1_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). 27/47 Gene Ontology MF GO:0016303 2.86420088047384e-06 5.16873152851788e-06 505 546.636363636364 551 2.60382237219177e-07 360 1.74974387088094 -1.52431132450055 -1 8.9143908527302 551 559 360 437 502 501 621 839 402 612 629 596 M18886 GO_TRANSLATION_REPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_REPRESSOR_ACTIVITY.html Antagonizes ribosome-mediated translation of mRNA into a polypeptide. 18/22 Gene Ontology MF GO:0030371 6.19265973949672e-07 1.95615192380487e-06 490 535.818181818182 553 5.62969225694121e-08 195 1.26864737319893 -0.815823204868428 -1 6.96695323841343 486 690 553 756 271 360 195 515 664 681 723 597 M19095 GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a G-protein coupled receptor. 215/333 Gene Ontology MF GO:0001664 4.49469355682127e-07 1.75978679936562e-06 665 458.454545454545 553 4.08608588646049e-08 38 2.29364605979145 2.44268741791638 1 12.7438999192882 662 263 53 463 211 611 813 771 553 38 605 598 M18005 GO_CORE_PROMOTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. 190/242 Gene Ontology MF GO:0001047 1.34774053709126e-06 3.00413668704452e-06 555 563.727272727273 554 1.225219420664e-07 399 1.60620835933924 -1.49891399702097 -1 8.54557438970309 554 655 516 451 399 666 438 696 636 547 643 599 M18228 GO_S100_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_S100_PROTEIN_BINDING.html Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. 17/20 Gene Ontology MF GO:0044548 7.33495621938261e-07 2.10958918882098e-06 410 539 554 6.66814424082748e-08 247 1.56290635344136 -1.27411091038275 -1 8.54636419573204 407 507 466 601 302 554 617 821 727 247 680 600 M18084 GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DNA_HYBRID_RIBONUCLEASE_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. 7/7 Gene Ontology MF GO:0004523 0.000103021899124892 0.000116943777385013 195 571.727272727273 555 1.03026675516806e-05 194 0.96936466573135 0.96936466573135 1 3.63983446526648 194 772 820 555 812 318 295 534 747 738 504 601 M18807 GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in). 7/12 Gene Ontology MF GO:0043225 3.99598983529093e-06 6.69430804499041e-06 805 517.909090909091 555 3.99599702087976e-07 71 2.14956076198592 -2.54554118637349 -1 10.7301349138774 805 211 884 71 555 402 134 918 600 288 829 602 M18927 GO_RETINOL_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. 13/32 Gene Ontology MF GO:0004745 6.727678334839e-05 7.81933934766194e-05 415 553.090909090909 556 6.11625825313313e-06 318 2.48528249458607 -2.95426057435361 -1 9.84194120013752 412 641 318 625 786 647 508 415 803 556 373 603 M17992 GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_5_BISPHOSPHATE_3_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. 10/10 Gene Ontology MF GO:0052629 8.80426447677111e-05 0.00010068243040268 65 379.272727272727 557 8.00419712523078e-06 8 0.953367273592124 -0.953367273592124 -1 3.63895104607514 61 598 582 557 807 37 8 71 646 714 91 604 M18455 GO_CO_SMAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CO_SMAD_BINDING.html Interacting selectively and non-covalently with a common mediator SMAD signaling protein. 13/19 Gene Ontology MF GO:0070410 2.29412929643568e-06 4.38876908883347e-06 715 592 557 2.08557426247744e-07 383 1.4966758880326 -1.31096489320145 -1 7.72000344831476 712 594 435 433 473 711 383 855 557 463 896 605 M19175 GO_ACID_THIOL_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_THIOL_LIGASE_ACTIVITY.html Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 13/20 Gene Ontology MF GO:0016878 3.8413831884964e-05 4.65195028331674e-05 365 498.181818181818 557 3.49222751262288e-06 157 1.69363021362436 -1.40795867738434 -1 7.05930693379685 598 361 385 362 755 591 428 559 157 557 727 606 M19219 GO_STRUCTURE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. 134/179 Gene Ontology MF GO:0043566 3.71194446739058e-06 6.30484685270018e-06 485 538.181818181818 557 3.37450066397668e-07 350 1.50673875343377 1.48545006570246 1 7.54238501348043 481 719 624 569 535 366 557 350 656 633 430 607 M17963 GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. 26/28 Gene Ontology MF GO:0052866 1.40705780181032e-05 1.90633637664625e-05 90 420.636363636364 558 1.27915163730437e-06 87 1.04159271805546 -1.16676744953431 -1 4.71105217218132 87 563 649 558 671 130 268 148 635 776 142 608 M18032 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. 143/223 Gene Ontology MF GO:0001227 6.04602858702757e-07 1.93976750500468e-06 420 588.636363636364 558 5.49639113508604e-08 217 1.81273943708844 -1.44321606859263 -1 9.98565869416155 420 846 431 888 268 361 217 922 712 558 852 609 M18371 GO_TRANSCRIPTION_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COFACTOR_BINDING.html Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. 29/34 Gene Ontology MF GO:0001221 3.71348993491686e-05 4.52673443253718e-05 295 487.818181818182 558 3.3759569256822e-06 77 0.959614237101893 -0.972331204433281 -1 3.98626278538088 215 558 651 567 750 291 77 291 809 726 431 610 M18182 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS.html Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. 42/47 Gene Ontology MF GO:0016706 2.01602992585982e-05 2.61263906240459e-05 560 548.727272727273 559 1.83277127321473e-06 125 1.35253206151954 1.64414690562489 1 5.95479374819378 559 547 580 747 703 882 511 125 492 695 195 611 M18343 GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_NUCLEAR_PORE.html The action of a molecule that contributes to the structural integrity of the nuclear pore complex. 14/14 Gene Ontology MF GO:0017056 3.34468231369635e-05 4.0987884056438e-05 55 417.545454545455 559 3.04066651302103e-06 4 0.94387718699251 0.94387718699251 1 3.95944110826232 51 639 661 559 746 45 4 150 760 718 260 612 M18982 GO_HISTONE_ACETYLTRANSFERASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_ACETYLTRANSFERASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone acetyltransferase. 33/38 Gene Ontology MF GO:0035035 4.52761286013377e-06 7.31942644031998e-06 625 565.272727272727 559 4.11602016183123e-07 222 2.07919520695161 2.67222005954829 1 10.2988479300416 621 551 344 338 559 661 905 698 222 503 816 613 M18406 GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 928/1422 Gene Ontology MF GO:0001071 1.68417329730676e-06 3.49702500384595e-06 425 595.545454545455 560 1.68417457370598e-07 291 1.67843439866171 -1.54002182689887 -1 8.8249919969751 291 835 855 868 440 425 421 560 661 672 523 614 M18574 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 270/414 Gene Ontology MF GO:0000982 5.28291782263402e-07 1.87024687461194e-06 615 501.727272727273 560 4.80265371930489e-08 240 2.02790300360834 -1.77403570412965 -1 11.2088154013278 560 654 242 693 240 545 474 613 606 277 615 615 M18962 GO_MAP_KINASE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAP_KINASE_KINASE_ACTIVITY.html Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. 16/17 Gene Ontology MF GO:0004708 2.87911385449634e-07 1.66268825097163e-06 775 545.909090909091 560 2.61737657389329e-08 125 1.70725552949127 -1.47041740429105 -1 9.51212272477868 775 350 453 236 125 924 889 811 190 560 692 616 M18075 GO_KINASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_BINDING.html Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group. 721/914 Gene Ontology MF GO:0019900 2.07475474511257e-07 1.65381926038186e-06 705 456.363636363636 561 2.07475493881992e-08 22 1.81158503529135 2.06255870608599 1 10.100950800408 703 234 818 22 77 696 896 561 276 138 599 617 M18708 GO_PEPTIDE_HORMONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_BINDING.html Interacting selectively and non-covalently with any peptide with hormonal activity in animals. 25/55 Gene Ontology MF GO:0017046 2.51563181886574e-07 1.65381926038186e-06 920 549 562 2.28693827865499e-08 93 2.13824217530494 -1.77229381263339 -1 11.9325380771009 917 562 260 543 93 655 371 840 667 358 773 618 M17970 GO_COMPLEMENT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_BINDING.html Interacting selectively and non-covalently with any component or product of the complement cascade. 17/27 Gene Ontology MF GO:0001848 0.000583504059811938 0.000624748263344415 325 562.909090909091 564 5.30598981427244e-05 128 1.96932296898781 -2.22445071666751 -1 6.06316662342618 325 904 564 830 910 479 274 158 862 758 128 619 M18442 GO_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 146/156 Gene Ontology MF GO:0004386 1.59050242877677e-05 2.12680787871163e-05 335 580.454545454545 565 1.4459217522912e-06 331 1.35743630547414 1.46387643759242 1 6.09422013609646 331 781 770 573 682 416 448 565 500 832 487 620 M17935 GO_BHLH_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BHLH_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. 30/36 Gene Ontology MF GO:0043425 4.02776177914996e-06 6.7177831839974e-06 805 529.454545454545 566 3.66160832108944e-07 175 1.34071363232494 -1.34070723425736 -1 6.66922768509408 308 802 604 566 544 284 175 703 801 669 368 621 M18888 GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. 25/27 Gene Ontology MF GO:0003887 3.21555580541928e-05 3.96156475227655e-05 210 472 566 2.9232752776982e-06 135 1.21842263167541 1.34730420199332 1 5.14509701478702 278 566 621 783 742 135 208 205 813 631 210 622 M18050 GO_ATPASE_ACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVATOR_ACTIVITY.html Binds to and increases the ATP hydrolysis activity of an ATPase. 21/24 Gene Ontology MF GO:0001671 4.75278136452901e-06 7.62425343893196e-06 540 563.636363636364 567 4.32071966568713e-07 281 1.50813002203549 1.33034510263774 1 7.42870191920971 539 635 514 675 567 345 281 850 686 471 637 623 M18304 GO_GLUCOSE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_BINDING.html Interacting selectively and non-covalently with the D- or L-enantiomer of glucose. 12/16 Gene Ontology MF GO:0005536 2.59834219815977e-05 3.26204917268971e-05 515 610.090909090909 567 2.36215716978911e-06 418 1.13817793274806 -0.645644242689799 -1 4.89564536363156 515 764 534 754 725 567 501 601 418 819 513 624 M18891 GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. 36/52 Gene Ontology MF GO:0001102 3.11909390539028e-06 5.50008161942865e-06 160 515.909090909091 568 2.83554393414244e-07 113 1.51329735383674 -1.49609717543434 -1 7.66250148724306 160 882 568 796 514 175 113 571 815 763 318 625 M18931 GO_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVITY.html Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. 20/35 Gene Ontology MF GO:0004629 0.000265076502426937 0.000289174366283931 570 610.545454545455 569 2.4100767882084e-05 198 2.58252064332178 2.50905422732506 1 8.80664691543913 869 569 240 411 840 844 895 769 513 198 568 626 M18974 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 45/73 Gene Ontology MF GO:0016903 2.02086197692995e-06 4.02298873906755e-06 640 565 569 1.83714893931168e-07 298 2.12278210103102 1.54760405282406 1 11.0510574619904 639 623 386 551 451 442 298 743 709 569 804 627 M18999 GO_PROTEIN_N_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 125/154 Gene Ontology MF GO:0047485 2.44421218966488e-06 4.56252942070777e-06 860 636.363636363636 570 2.22201355018399e-07 396 1.64032250645501 1.80798456395997 1 8.43956491831316 859 534 570 446 485 744 518 776 396 813 859 628 M19188 GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING.html Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily. 45/57 Gene Ontology MF GO:0032813 1.25933132249724e-07 1.58112794444989e-06 625 494.181818181818 570 1.14484672234938e-08 23 1.58878209597057 -1.81118436142836 -1 8.88175944864856 372 619 488 621 23 584 624 337 859 570 339 629 M17850 GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_TYROSINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 54/77 Gene Ontology MF GO:0004712 1.0947936662302e-06 2.62136737387135e-06 575 568.272727272727 572 9.95267464578699e-08 368 1.67917438205808 1.74257150537884 1 9.03274943942039 572 485 481 490 368 636 728 658 415 572 846 630 M18499 GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery. 59/77 Gene Ontology MF GO:0000979 5.0108459088703e-07 1.84352199509307e-06 775 578.090909090909 572 4.55531550015419e-08 230 1.35385454146292 1.47061042728339 1 7.4725052931834 773 616 572 608 230 913 547 498 774 520 308 631 M19037 GO_ACID_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. 10/12 Gene Ontology MF GO:0003993 1.63580924391563e-05 2.1810789918875e-05 340 498.454545454545 574 1.4871103700875e-06 142 1.25801054248958 1.30846747445368 1 5.6303416980851 336 766 574 820 684 193 142 246 752 648 322 632 M18577 GO_NAD_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BINDING.html Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. 56/74 Gene Ontology MF GO:0051287 9.52768117165387e-07 2.4328972470992e-06 605 503.727272727273 575 8.66153208897308e-08 304 1.63777378726672 1.33178917068868 1 8.86011485527488 600 304 510 333 344 575 603 606 390 602 674 633 M18775 GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription. 60/81 Gene Ontology MF GO:0033613 2.42201692048796e-06 4.55334853789727e-06 295 550 576 2.20183598811922e-07 193 1.53658527484585 -1.40067753979721 -1 7.90354663836991 292 791 576 645 481 335 193 631 757 784 565 634 M18237 GO_HORMONE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_ACTIVITY.html The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. 44/137 Gene Ontology MF GO:0005179 3.18366708072004e-07 1.69329794462269e-06 70 456.454545454545 579 2.89424321948674e-08 49 3.21949209617788 3.37037163097076 1 17.9631853664551 651 543 49 611 141 789 766 69 579 69 754 635 M19113 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY_H3_K4_SPECIFIC_.html Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. 17/19 Gene Ontology MF GO:0042800 0.000484091664614572 0.000521329484969539 385 620.727272727273 579 4.4018019797896e-05 183 0.542671061656965 -0.628549136350276 -1 1.67105192128001 385 820 728 572 850 391 183 579 894 856 570 636 M19122 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. 17/18 Gene Ontology MF GO:0015095 6.67643679052849e-05 7.77935383915299e-05 705 583.454545454545 579 6.06967219263802e-06 283 1.85282369391242 -1.7623028386939 -1 7.32691410511204 702 508 401 618 784 893 817 328 283 505 579 637 M17893 GO_HEAT_SHOCK_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAT_SHOCK_PROTEIN_BINDING.html Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock. 108/119 Gene Ontology MF GO:0031072 5.34047616698729e-06 8.39217683383717e-06 785 567.636363636364 580 4.85499011907217e-07 286 1.37028601007131 1.23029378405071 1 6.68914301656266 435 784 732 688 580 286 386 456 785 636 476 638 M18409 GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_1_3_GALACTOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. 10/15 Gene Ontology MF GO:0048531 0.000164247205871228 0.000182190177941194 780 632.909090909091 581 1.4932679044684e-05 414 1.33358866617125 -1.59421940683473 -1 4.77972726823985 414 524 485 780 828 526 780 581 825 717 502 639 M18515 GO_ELECTRON_CARRIER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_CARRIER_ACTIVITY.html Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 114/160 Gene Ontology MF GO:0009055 1.53636167145863e-06 3.30139112657622e-06 235 557.636363636364 581 1.39669340397458e-07 234 1.60793117294092 1.63582976763519 1 8.4909006129744 234 782 616 887 415 387 393 519 586 734 581 640 M18375 GO_DIOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOXYGENASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. 69/89 Gene Ontology MF GO:0051213 2.5973097980109e-06 4.77120129893056e-06 845 617.181818181818 582 2.36119351307988e-07 432 1.54328868572983 -1.36868627241004 -1 7.90789486631541 844 729 557 816 493 629 432 533 582 658 516 641 M18534 GO_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_ACTIVITY.html Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 248/313 Gene Ontology MF GO:0016791 3.25645355187062e-07 1.69329794462269e-06 705 525.363636363636 583 2.96041275808452e-08 147 1.71727193127709 1.88598579754491 1 9.55506809805556 704 390 511 614 147 337 583 832 425 601 635 642 M18063 GO_ANION_CATION_SYMPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_CATION_SYMPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). 32/65 Gene Ontology MF GO:0015296 5.50963551956397e-06 8.59949868256269e-06 870 471.181818181818 585 5.00877210712014e-07 47 3.13106925640005 2.51642058370925 1 15.3252264932119 868 87 82 47 585 815 713 873 106 183 824 643 M18378 GO_PALMITOYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALMITOYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. 29/36 Gene Ontology MF GO:0016409 6.01589789759158e-05 7.04523403976505e-05 440 578.363636363636 585 5.46914764414555e-06 340 1.4342078949707 -1.25955157815649 -1 5.71857712643588 440 742 605 703 780 585 516 437 340 651 563 644 M18564 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). 16/21 Gene Ontology MF GO:0016755 0.000322758511864078 0.000349623522816422 385 575.272727272727 585 2.93459884528622e-05 379 2.05786057208368 -1.95399015679001 -1 6.84144880434655 447 439 384 585 845 663 774 379 812 381 619 645 M18846 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. 22/25 Gene Ontology MF GO:0015215 2.46580435747129e-07 1.65381926038186e-06 900 545 585 2.24164057622151e-08 87 1.42190452414085 -1.33109417756484 -1 7.9159874894308 897 122 484 419 87 760 585 784 677 266 914 646 M18091 GO_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_ACTIVITY.html Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. 564/710 Gene Ontology MF GO:0004672 3.6658948102687e-07 1.69370198541451e-06 680 567.454545454545 588 3.66589541501415e-08 189 1.83314469829511 2.01759193765972 1 10.2034384973236 677 475 822 588 189 712 915 548 438 245 633 647 M19185 GO_CYTOKINE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a cytokine receptor. 202/377 Gene Ontology MF GO:0005126 1.46238717425982e-07 1.63698248897436e-06 740 454.090909090909 588 1.32944297406168e-08 30 2.2658273015528 2.21393760891856 1 12.6576814968764 739 267 61 459 30 784 635 746 588 82 604 648 M18281 GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRONIC_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within. 10/13 Gene Ontology MF GO:0044213 0.000145087246637826 0.000161518814329339 825 599.181818181818 589 1.31906196221528e-05 354 1.05224486006284 0.729987192497067 1 3.8127678002258 724 463 589 439 824 822 567 354 711 715 383 649 M18940 GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. 407/490 Gene Ontology MF GO:0004674 3.28833804994275e-07 1.69329794462269e-06 590 597.181818181818 590 2.98939867404587e-08 149 1.72139982452914 1.86623097904511 1 9.57817244144384 789 605 555 590 149 802 909 589 342 504 735 650 M18252 GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS.html Catalysis of the hydrolysis of any ester bond. 622/826 Gene Ontology MF GO:0016788 2.39183937998459e-07 1.65381926038186e-06 750 583.636363636364 591 2.39183963742493e-08 103 1.74597762777833 -1.78144824583494 -1 9.73308591047277 747 239 839 862 103 698 816 491 463 571 591 651 M18434 GO_BETA_TUBULIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_TUBULIN_BINDING.html Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin. 39/46 Gene Ontology MF GO:0048487 3.01995742429477e-06 5.37488441500206e-06 880 568.909090909091 594 2.74541960892929e-07 313 1.60570386455321 -0.924281483476979 -1 8.14943310966437 876 626 594 443 508 609 783 336 313 724 446 652 M18737 GO_ANION_ANION_ANTIPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_ANION_ANTIPORTER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). 13/29 Gene Ontology MF GO:0015301 0.000175416819550668 0.000194346692164049 585 603.181818181818 594 1.5948255268902e-05 445 1.77156384922576 -2.11639829148528 -1 6.31990967297587 581 640 450 552 829 594 696 445 710 465 673 653 M18859 GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. 12/39 Gene Ontology MF GO:0005251 2.99367394529282e-05 3.70798220569781e-05 665 512.090909090909 594 2.72155880255723e-06 105 3.563294133756 3.42831597367481 1 15.2553508968112 663 451 105 594 737 596 625 485 660 155 562 654 M18285 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 443/695 Gene Ontology MF GO:0000981 6.5396787393419e-07 1.96441409293938e-06 595 551.090909090909 595 5.94516425755941e-08 287 1.92293054791723 -1.7433750106676 -1 10.5858795314945 596 777 355 692 287 595 535 637 591 321 676 655 M18207 GO_CALCIUM_DEPENDENT_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. 64/103 Gene Ontology MF GO:0048306 7.8690828240003e-06 1.14866232691568e-05 430 575.727272727273 597 7.15373724610546e-07 400 1.58346534291767 -1.47673128474639 -1 7.52927516349599 429 400 454 668 627 614 593 562 772 597 617 656 M17880 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. 38/59 Gene Ontology MF GO:0016620 8.88000751227778e-06 1.28205108458511e-05 600 597.272727272727 598 8.07276668677278e-07 396 2.11296117340992 1.54988817825414 1 9.9681869438477 693 665 396 435 632 565 457 598 719 598 812 657 M17865 GO_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. 435/804 Gene Ontology MF GO:0008233 5.10773195661046e-07 1.85808831807404e-06 510 545.727272727273 599 4.64339376588283e-08 221 2.05826196385862 -2.0676973305731 -1 11.3831217255208 510 652 221 883 235 694 614 671 473 599 451 658 M18104 GO_HYDRO_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDRO_LYASE_ACTIVITY.html Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. 44/52 Gene Ontology MF GO:0016836 5.87740044099471e-06 9.03613645171234e-06 675 591.363636363636 600 5.34310558436095e-07 369 1.51241103357842 -1.78414197693671 -1 7.34172345326354 672 622 521 698 594 710 566 478 369 600 675 659 M18194 GO_RAN_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAN_GTPASE_BINDING.html Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. 33/38 Gene Ontology MF GO:0008536 6.27699975168279e-06 9.4969588353164e-06 840 521.818181818182 600 5.70637969197744e-07 119 0.833273041825009 0.882026532299163 1 4.00204462388922 119 801 752 686 600 265 164 343 838 836 336 660 M19102 GO_ADENYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. 1305/1625 Gene Ontology MF GO:0030554 6.49707890632058e-07 1.96186304230072e-06 655 591.727272727273 600 6.49708080586289e-08 298 1.71460190946807 1.81380803077136 1 9.43380778138378 655 533 913 519 298 600 775 654 362 577 623 661 M18589 GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_APURINIC_OR_APYRIMIDINIC_SITE_LYASE_ACTIVITY.html Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 14/17 Gene Ontology MF GO:0003906 1.21414670855912e-05 1.66945172426879e-05 925 646.818181818182 601 1.10377582663895e-06 376 1.84214430768124 -1.75628916169445 -1 8.47843869695086 923 698 491 498 661 601 376 909 528 588 842 662 M18893 GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma. 15/18 Gene Ontology MF GO:0042975 1.45220191831326e-05 1.95602707364643e-05 195 505.181818181818 601 1.32019227660669e-06 85 1.44455889058418 -1.09663670104913 -1 6.53992815462176 195 761 608 562 676 342 85 334 706 687 601 663 M19036 GO_CYTOKINE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_RECEPTOR_ACTIVITY.html Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. 50/95 Gene Ontology MF GO:0004896 5.9396911552234e-07 1.92595208502953e-06 775 545.545454545455 602 5.39972068987021e-08 100 2.56236167071378 2.69009354417402 1 14.1461986784885 774 307 100 863 264 643 898 525 602 105 920 664 M18205 GO_SINGLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with single-stranded RNA. 96/138 Gene Ontology MF GO:0003727 1.0706717858203e-05 1.50578497731804e-05 360 558.454545454545 603 9.73342724075821e-07 277 1.75084819074713 1.66224838084656 1 8.13152850597722 357 723 528 603 649 306 277 861 376 801 662 665 M18824 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. 63/69 Gene Ontology MF GO:0030374 3.86398967156553e-07 1.70429971387201e-06 605 589.090909090909 603 3.51271850020089e-08 182 1.32481267470713 1.5937745704777 1 7.35481001484438 603 615 657 676 182 577 692 592 603 732 551 666 M18199 GO_FATTY_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BINDING.html Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 25/52 Gene Ontology MF GO:0005504 1.61902727493177e-06 3.4131789268273e-06 890 605.818181818182 604 1.47184406037269e-07 249 2.72635259506218 -3.36121254842443 -1 14.3980923236957 889 565 249 604 422 819 838 738 551 357 632 667 M18469 GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_TRANSPORTING_ATPASE_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). 7/12 Gene Ontology MF GO:0008556 5.92811850860583e-06 9.06884354627779e-06 675 495.636363636364 604 5.92813432283029e-07 172 2.3206727595743 1.93168226141289 1 11.2920639243883 671 209 861 204 604 472 620 222 668 172 749 668 M19139 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. 103/141 Gene Ontology MF GO:0001085 1.99194928517041e-06 3.99254043274938e-06 450 558.181818181818 604 1.81086462613301e-07 251 1.6393207547951 1.87549638486796 1 8.5265184988984 604 783 554 687 448 422 649 251 619 673 450 669 M18549 GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_BINDING.html Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein. 25/27 Gene Ontology MF GO:0016922 5.43545413454644e-06 8.51247393274731e-06 680 527.636363636364 605 4.94133414887026e-07 224 1.02516521199806 -1.08177271163005 -1 4.98398134999534 224 676 680 639 582 384 255 614 605 842 303 670 M18007 GO_NEUROPEPTIDE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a neuropeptide receptor. 13/31 Gene Ontology MF GO:0071855 3.95716744417432e-05 4.77963754041447e-05 760 566.363636363636 607 3.59748965821021e-06 218 2.47303751912822 2.63210788814145 1 10.3058924186229 641 593 218 741 757 759 447 607 685 359 423 671 M18547 GO_AMIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BINDING.html Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 225/369 Gene Ontology MF GO:0033218 4.92926606086472e-07 1.84352199509307e-06 910 564.818181818182 607 4.4811519684585e-08 224 1.79801823430025 -1.46067600782085 -1 9.94264441326774 909 262 354 690 224 754 607 764 478 414 757 672 M17971 GO_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a receptor for hormones. 178/307 Gene Ontology MF GO:0051427 2.86965289407973e-06 5.16873152851788e-06 620 619.909090909091 608 2.60877876111495e-07 473 1.38671959926727 -1.16846155047921 -1 7.05312904694667 617 656 738 509 503 599 473 578 608 741 797 673 M18301 GO_FOLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_BINDING.html Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 11/12 Gene Ontology MF GO:0005542 8.96011723570818e-06 1.28958696663464e-05 610 482.090909090909 608 8.14559429864323e-07 28 2.97540482528078 2.66800507557249 1 14.0526913194126 608 180 197 305 634 713 803 721 28 267 847 674 M17887 GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_5_CYCLIC_AMP_PHOSPHODIESTERASE_ACTIVITY.html Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. 11/16 Gene Ontology MF GO:0004115 1.35598454601576e-06 3.00413668704452e-06 375 590.090909090909 609 1.23271398344229e-07 336 1.8735587586858 1.60673085182732 1 9.97741052807528 831 372 336 529 401 883 770 628 609 371 761 675 M18443 GO_RNA_POLYMERASE_CORE_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_CORE_ENZYME_BINDING.html Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. 28/29 Gene Ontology MF GO:0043175 5.9771399831671e-06 9.11022900062218e-06 465 582.272727272727 609 5.4337783840107e-07 225 1.31887086262302 -1.71625304814897 -1 6.39042323788836 461 744 644 609 596 727 918 386 225 855 240 676 M18870 GO_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STORE_OPERATED_CALCIUM_CHANNEL_ACTIVITY.html A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. 6/11 Gene Ontology MF GO:0015279 6.25578005910454e-06 9.4943589688677e-06 795 607.090909090909 609 6.25579766982718e-07 183 2.38866514606494 -3.15553911988511 -1 11.5784350874567 795 601 890 423 609 896 818 213 183 494 756 677 M18926 GO_INORGANIC_ANION_EXCHANGER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_EXCHANGER_ACTIVITY.html Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). 7/24 Gene Ontology MF GO:0005452 0.00108127951231984 0.001145759483238 105 520.363636363636 609 0.000108180599732067 103 2.25622966270459 2.25622966270459 1 6.3784270870297 241 708 899 630 867 103 105 609 730 537 295 678 M18046 GO_PROTEIN_DIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DIMERIZATION_ACTIVITY.html The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. 1032/1514 Gene Ontology MF GO:0046983 3.10944791438355e-07 1.69329794462269e-06 890 566.181818181818 612 3.10944834947362e-08 93 1.92848794552312 2.0286016550801 1 10.7372709856475 888 228 815 386 157 612 834 887 416 93 912 679 M19149 GO_MONOCARBOXYLIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BINDING.html Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). 45/99 Gene Ontology MF GO:0033293 7.35255291763926e-06 1.08526499934484e-05 610 555.454545454545 612 6.6841613549974e-07 274 2.33228161373496 -2.60022367641566 -1 11.1724422860731 606 662 274 677 619 722 623 474 612 409 432 680 M18048 GO_UNFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with an unfolded protein. 101/120 Gene Ontology MF GO:0051082 6.66905444202486e-06 1.00198476494812e-05 350 655.818181818182 613 6.06279514418619e-07 348 1.12936738349826 1.22937316130693 1 5.41878750565672 348 852 779 806 607 478 467 599 841 824 613 681 M17949 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 30/38 Gene Ontology MF GO:0001106 6.65933332247615e-05 7.76922220955551e-05 615 625.636363636364 615 6.05412264274567e-06 344 1.29005196561957 0.946295098920177 1 5.08493650629262 580 743 615 729 783 474 573 344 780 613 648 682 M17952 GO_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 28/38 Gene Ontology MF GO:0019212 7.28899894450105e-06 1.07760560395503e-05 620 648.818181818182 618 6.62638463126213e-07 489 1.62740770565584 -1.76356647037018 -1 7.78356265779926 864 495 489 617 618 809 719 647 558 510 811 683 M18677 GO_RAL_GTPASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAL_GTPASE_BINDING.html Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases. 18/21 Gene Ontology MF GO:0017160 3.25421938791987e-05 3.99853552451857e-05 420 531 619 2.95842502275002e-06 72 1.31435274497761 -1.01628753399244 -1 5.54950959039412 419 753 619 605 744 252 72 165 663 721 828 684 M17984 GO_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. 44/47 Gene Ontology MF GO:0033558 7.46842178516332e-06 1.10060952623459e-05 425 514.090909090909 620 6.78949739873899e-07 132 0.935048451398766 0.918394307442548 1 4.43969796413384 425 663 735 345 620 132 191 632 728 736 448 685 M18987 GO_2_IRON_2_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_IRON_2_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. 24/29 Gene Ontology MF GO:0051537 2.1134999006959e-06 4.18174284420345e-06 735 624.454545454545 620 1.9213653919086e-07 374 1.43192616890917 1.11641672415076 1 7.41270690209479 734 677 577 715 455 559 374 620 540 708 910 686 M18172 GO_PROTEIN_C_TERMINUS_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_C_TERMINUS_BINDING.html Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 253/295 Gene Ontology MF GO:0008022 3.61851525235603e-07 1.69370198541451e-06 765 563.272727272727 621 3.28955986138381e-08 168 1.61761260464079 1.74694890758787 1 8.99709962309612 761 256 587 237 168 773 718 897 314 621 864 687 M18303 GO_E_BOX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_E_BOX_BINDING.html Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. 25/40 Gene Ontology MF GO:0070888 1.15802195514696e-05 1.60417188997673e-05 590 602.727272727273 622 1.05275277337629e-06 369 1.986326212549 -2.08329974975876 -1 9.17984382991609 586 809 422 710 653 716 484 622 692 567 369 688 M19212 GO_MRNA_3_UTR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_UTR_BINDING.html Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. 54/64 Gene Ontology MF GO:0003730 6.91346051830576e-06 1.03701907774586e-05 355 634.909090909091 622 6.2849838580245e-07 355 1.50047298400068 1.58328908395272 1 7.19629801013831 355 867 702 802 610 592 541 411 714 768 622 689 M18111 GO_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Interacting selectively and non-covalently with an identical protein to form a homodimer. 729/1017 Gene Ontology MF GO:0042803 2.37447913687092e-07 1.65381926038186e-06 750 500.727272727273 624 2.37447939058776e-08 101 1.92704557391867 -1.86551884231916 -1 10.7483453545301 746 235 825 205 101 840 725 715 385 107 624 690 M19160 GO_EXODEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXODEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. 18/19 Gene Ontology MF GO:0004529 3.30986001771493e-05 4.06150153568206e-05 510 648.727272727273 624 3.00900892273294e-06 464 1.00379306190977 1.10355689918918 1 4.21824465190259 506 754 614 721 745 484 464 624 833 775 616 691 M18103 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. 7/12 Gene Ontology MF GO:0004865 2.22645852421863e-05 2.84543247078564e-05 835 540 625 2.22648083156221e-06 65 3.03941765021186 -3.06512929417581 -1 13.3431208548933 832 383 824 219 717 625 416 785 65 404 670 692 M18606 GO_O_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. 38/49 Gene Ontology MF GO:0008374 2.21649405300035e-05 2.8405554853985e-05 670 579.454545454545 625 2.01501489493909e-06 253 1.76051670758053 -1.65956365584054 -1 7.70611848483434 670 625 456 652 711 770 722 401 253 540 574 693 M18738 GO_TASTE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TASTE_RECEPTOR_ACTIVITY.html Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. 5/40 Gene Ontology MF GO:0008527 0.00468017552262427 0.00486443440146774 430 594.636363636364 625 0.00046900616581469 41 1.73839478055899 -2.05888911834387 -1 3.84280638457787 428 648 876 818 922 308 41 625 853 578 444 694 M18959 GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_BUT_NOT_PEPTIDE_BONDS_IN_LINEAR_AMIDES.html Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. 75/103 Gene Ontology MF GO:0016811 2.38125514947703e-06 4.49036685329955e-06 700 603.636363636364 626 2.16477975174965e-07 368 1.32938574375777 -1.32843738271719 -1 6.83795001035171 697 483 683 560 480 805 638 626 368 727 573 695 M18633 GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. 20/21 Gene Ontology MF GO:0052745 1.96060630019621e-05 2.55875737483234e-05 630 627.545454545455 629 1.78238524821566e-06 357 0.955552217047047 -1.06655834679421 -1 4.19874926349216 534 429 626 629 698 777 882 486 687 798 357 696 M18734 GO_ENDONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. 113/143 Gene Ontology MF GO:0004519 6.76103728372365e-07 2.00917406078607e-06 720 604.272727272727 629 6.14639941956881e-08 289 1.53819257591035 1.39730330579506 1 8.44192252910238 614 720 645 893 289 398 400 716 629 625 718 697 M18593 GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 87/117 Gene Ontology MF GO:0001191 3.71459776466674e-07 1.69915264086736e-06 870 603.818181818182 630 3.37690762896315e-08 176 1.70021418338832 1.6263506106814 1 9.45712197163736 866 481 499 450 176 702 782 818 630 369 869 698 M18625 GO_DEATH_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEATH_RECEPTOR_BINDING.html Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). 21/23 Gene Ontology MF GO:0005123 1.06109754847501e-07 1.5319595856108e-06 560 589.636363636364 632 9.64634181503235e-09 15 1.28780359486999 -1.57112351084405 -1 7.20559097031162 556 632 559 751 15 723 726 713 733 604 474 699 M18232 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II. 72/118 Gene Ontology MF GO:0003705 3.24674488497945e-06 5.66036278060568e-06 745 631.363636363636 633 2.95159061501195e-07 339 1.84690550160873 2.00198733600024 1 9.3418678659495 745 727 445 708 520 910 618 633 615 339 685 700 M18568 GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALMODULIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin. 26/31 Gene Ontology MF GO:0004683 8.94436529287865e-06 1.28932816390326e-05 710 595.363636363636 633 8.13127423407392e-07 99 2.26809951383929 1.91477528337364 1 10.6988310726541 708 561 338 372 633 856 914 766 99 466 836 701 M18013 GO_LEUCINE_ZIPPER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUCINE_ZIPPER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. 11/14 Gene Ontology MF GO:0043522 9.38912427913364e-05 0.000106841759038417 610 662.636363636364 635 8.53593182781693e-06 500 1.06743049425729 0.959056606555282 1 4.05441479845682 500 703 609 635 803 621 660 603 872 675 608 702 M18250 GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_ELONGATION_FACTOR_ACTIVITY.html Functions in chain elongation during polypeptide synthesis at the ribosome. 18/20 Gene Ontology MF GO:0003746 2.28160443055839e-05 2.90786550873925e-05 635 616.636363636364 635 2.07420735750913e-06 351 0.814220968245132 1.00609619592184 1 3.52548112590439 635 351 663 496 713 706 826 513 526 861 493 703 M18507 GO_PHOSPHOTYROSINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTYROSINE_BINDING.html Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein. 19/23 Gene Ontology MF GO:0001784 0.000253959501463527 0.000277702460771952 865 613.181818181818 636 2.30898929369096e-05 292 1.47084889007268 -1.27319888092476 -1 5.01639914188048 865 570 504 292 839 717 636 685 405 564 668 704 M18495 GO_GLYCOLIPID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BINDING.html Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. 22/28 Gene Ontology MF GO:0051861 1.35349705504087e-06 3.00413668704452e-06 640 582.363636363636 637 1.23045262522553e-07 208 3.36023974223827 2.75063773037078 1 17.9395589433532 637 678 208 285 400 660 732 572 759 566 909 705 M18025 GO_RACEMASE_AND_EPIMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RACEMASE_AND_EPIMERASE_ACTIVITY.html Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. 16/18 Gene Ontology MF GO:0016854 5.6818711714257e-05 6.66249868324537e-05 785 637.272727272727 638 5.1654708369463e-06 390 1.47359227002499 1.01880603779229 1 5.91183917109525 782 817 601 669 779 590 540 390 682 638 522 706 M18381 GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. 18/24 Gene Ontology MF GO:0005385 3.05883562187414e-05 3.78361996601299e-05 660 628.454545454545 638 2.78079832012315e-06 412 1.65902168889587 -1.58358908165044 -1 7.05826262723307 726 638 524 602 739 659 412 555 657 534 867 707 M18072 GO_RNA_POLYMERASE_I_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_I_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 12/14 Gene Ontology MF GO:0001054 7.84057983329855e-05 9.06720371209995e-05 150 500.545454545455 639 7.12805388878195e-06 18 0.833925846219438 0.927283977492688 1 3.21272617566091 150 911 639 794 790 118 18 102 860 818 306 708 M18815 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. 27/49 Gene Ontology MF GO:0016684 0.00900261864545781 0.00927360047759534 355 598.454545454545 639 0.000821788245380848 313 1.80870397787118 -1.45814046183072 -1 3.50898731147785 353 674 494 744 891 580 313 400 791 704 639 709 M18860 GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_DEPENDENT_PROTEIN_DEACETYLASE_ACTIVITY.html Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. 16/18 Gene Ontology MF GO:0034979 4.22913693832417e-06 6.94089259504713e-06 640 654.727272727273 639 3.84467733469445e-07 440 0.931581136273626 -0.951112954422577 -1 4.60391580937308 777 440 637 447 551 837 571 684 761 639 858 710 M18533 GO_GLUCOCORTICOID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a glucocorticoid receptor. 17/19 Gene Ontology MF GO:0035259 0.00263414319107932 0.00275022407746587 290 562.636363636364 640 0.000239754767943236 98 0.949396237405992 -0.975122765144358 -1 2.30097957678543 289 755 640 508 878 216 98 697 890 759 459 711 M18318 GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_SEVERING_ATPASE_ACTIVITY.html Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. 9/11 Gene Ontology MF GO:0008568 5.05602814079571e-05 5.98177977220901e-05 795 665.181818181818 641 5.05614317987198e-06 465 1.02550729818157 -0.850214930726204 -1 4.14349171162757 791 706 844 553 776 641 465 564 545 618 814 712 M18992 GO_DEACETYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEACETYLASE_ACTIVITY.html Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. 55/81 Gene Ontology MF GO:0019213 9.66563244079272e-06 1.3782475887797e-05 780 578.818181818182 641 8.78697718792112e-07 167 0.995649035909042 1.04372332397946 1 4.63677738247554 489 735 745 574 641 167 260 780 762 777 437 713 M18271 GO_DIPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of a dipeptide. 10/14 Gene Ontology MF GO:0016805 0.00122300159178708 0.00129148968092716 440 589.636363636364 642 0.000111243818179799 199 2.33407361219764 -2.10488161034212 -1 6.48274728061223 438 769 439 755 906 642 550 199 763 646 379 714 M18972 GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. 12/12 Gene Ontology MF GO:0004535 0.000266714172197792 0.00029061780083816 845 617.454545454545 642 2.42496829487986e-05 198 0.766887480091935 -0.606562465913001 -1 2.5736750026497 516 642 653 607 841 413 198 843 674 820 585 715 M19011 GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_COFACTOR_ACTIVITY.html Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery. 93/114 Gene Ontology MF GO:0001104 5.3243848243969e-07 1.87024687461194e-06 525 584.272727272727 642 4.84035101181055e-08 244 1.52600125370331 1.6111169723506 1 8.42061865374148 524 658 642 904 244 502 668 552 699 663 371 716 M18231 GO_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_ACTIVITY.html Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 731/917 Gene Ontology MF GO:0016301 3.63284783444584e-07 1.69370198541451e-06 840 588.636363636364 643 3.63284842833723e-08 187 1.75737135280904 1.93329570570651 1 9.77933306253519 822 387 837 523 187 836 835 643 466 235 704 717 M18579 GO_CHAPERONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_BINDING.html Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. 103/131 Gene Ontology MF GO:0051087 2.4763679317199e-06 4.58549893568975e-06 645 659.636363636364 643 2.25124610834363e-07 489 1.57877957740137 -1.34388635688769 -1 8.11745517512908 738 611 518 634 489 866 832 744 643 644 537 718 M18866 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. 11/23 Gene Ontology MF GO:0016863 2.99012479057196e-07 1.67574455080187e-06 360 566.454545454545 643 2.71829563361285e-08 131 1.03731680124061 -0.976836440335486 -1 5.75382557683166 359 643 575 670 131 521 689 660 750 677 556 719 M18985 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. 13/17 Gene Ontology MF GO:0005337 7.73378664909358e-07 2.17866428773246e-06 450 576.545454545455 643 7.03071760708859e-08 195 1.88075526839497 -2.54754561639697 -1 10.2704549922255 711 448 438 746 312 791 875 195 449 643 734 720 M18294 GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription. 30/36 Gene Ontology MF GO:0001103 7.9575414478638e-05 9.17948601476423e-05 280 485.727272727273 644 7.23439026530039e-06 88 0.95103317119569 0.999619589321281 1 3.66692133717477 277 670 690 644 792 88 133 353 800 700 196 721 M18764 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY_PHOSPHOTRANSFERASES.html Catalysis of the transfer of a phosphate group from one position to another within a single molecule. 10/10 Gene Ontology MF GO:0016868 7.04893082295971e-06 1.05051807748625e-05 625 675.818181818182 644 6.40813946204958e-07 540 1.04052625256684 -0.777122247718878 -1 4.96732933443053 622 644 586 819 614 540 552 807 840 647 763 722 M19142 GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 46/47 Gene Ontology MF GO:0016796 1.21706340755891e-06 2.815452174354e-06 845 634.545454545455 644 1.10642189168351e-07 354 0.839332237893452 0.943233042030896 1 4.46138331718466 514 873 756 844 382 354 356 522 842 893 644 723 M18956 GO_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_BINDING.html Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 457/607 Gene Ontology MF GO:0003682 1.29968362817088e-06 2.92904310348753e-06 545 633.545454545455 647 1.18153126907225e-07 395 1.50350867685488 1.53903668511097 1 8.01158117307432 544 776 753 732 395 512 682 510 647 843 575 724 M19161 GO_4_IRON_4_SULFUR_CLUSTER_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_IRON_4_SULFUR_CLUSTER_BINDING.html Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. 41/42 Gene Ontology MF GO:0051539 1.10946966322363e-05 1.54856490758102e-05 810 588.454545454545 650 1.00861387124307e-06 260 1.05444257980045 1.03402173294722 1 4.8621835710491 260 739 723 797 650 339 362 458 807 810 528 725 M18430 GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_ADP_RIBOSYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. 23/28 Gene Ontology MF GO:0003950 2.00578125114899e-05 2.60666930529067e-05 635 648.818181818182 652 1.82345412587833e-06 502 1.01205161405132 -1.01292998578898 -1 4.44245662628555 634 502 650 628 701 679 755 583 694 652 659 726 M18453 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. 75/107 Gene Ontology MF GO:0004197 0.000354696355983423 0.000383769827785343 445 618 652 3.2250323184835e-05 386 1.80535778502148 -1.9213182743778 -1 5.92417370755763 443 859 500 695 846 652 592 662 386 748 415 727 M18889 GO_COFACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BINDING.html Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 243/308 Gene Ontology MF GO:0048037 8.0232787065439e-07 2.23298479664053e-06 655 639.818181818182 652 7.29389239326447e-08 316 1.74566694220754 -1.86247732143145 -1 9.51058131620755 652 391 520 810 316 854 923 793 583 479 717 728 M19084 GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING.html Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. 313/461 Gene Ontology MF GO:0001159 2.25606842570165e-06 4.34566622245621e-06 730 635.545454545455 653 2.05097339933706e-07 423 1.82354029433109 2.04976265513803 1 9.42597071337243 729 653 423 544 469 817 699 702 580 491 884 729 M18880 GO_DRUG_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORTER_ACTIVITY.html Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 23/30 Gene Ontology MF GO:0090484 2.99162277828756e-06 5.33640819910754e-06 610 637.909090909091 654 2.71966076944484e-07 383 2.28872275263728 -2.08939711206219 -1 11.6470137797101 607 810 383 662 507 743 658 831 584 654 578 730 M18173 GO_GLYCINE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_BINDING.html Interacting selectively and non-covalently with glycine, aminoethanoic acid. 7/15 Gene Ontology MF GO:0016594 0.00345095076538544 0.00359490248840602 500 605.545454545455 655 0.000345632158511397 251 2.10360996760458 2.81527893212964 1 4.93001101479815 498 773 833 665 883 547 863 281 412 655 251 731 M18427 GO_MISMATCHED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCHED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. 11/14 Gene Ontology MF GO:0030983 0.00574926106813013 0.00596219666324606 270 567.454545454545 655 0.000524030983169776 53 0.793266271214523 0.793266271214523 1 1.65472682423783 270 914 655 838 885 250 53 385 919 809 264 732 M18798 GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_SPECIFIC_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. 15/16 Gene Ontology MF GO:0004549 2.45759304809968e-05 3.11497390458725e-05 405 606.272727272727 656 2.23420045636355e-06 251 0.761024326038794 0.816970582745591 1 3.26938671631251 403 699 656 788 718 358 251 644 873 731 548 733 M18847 GO_FUCOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 7/11 Gene Ontology MF GO:0008417 4.57001831313298e-05 5.44161974398824e-05 745 587.454545454545 656 4.57011229865648e-06 83 1.37027960130678 -2.17102099680983 -1 5.61021212301379 744 469 887 531 769 820 862 145 83 656 496 734 M18330 GO_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. 76/81 Gene Ontology MF GO:0004527 1.98055684361956e-06 3.97833592066189e-06 730 566.818181818182 657 1.80050784238569e-07 185 1.11166474266431 1.0219558152673 1 5.76545886221756 317 728 751 730 447 210 185 657 707 889 614 735 M19005 GO_P53_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_P53_BINDING.html Interacting selectively and non-covalently with one of the p53 family of proteins. 81/92 Gene Ontology MF GO:0002039 3.26223051653359e-07 1.69329794462269e-06 685 585.181818181818 657 2.96566454569789e-08 148 1.63482869505004 1.98647861286282 1 9.09362282233647 685 726 602 683 148 657 851 410 303 828 544 736 M18225 GO_GDP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_BINDING.html Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. 69/79 Gene Ontology MF GO:0019003 1.07910124195749e-06 2.61018206169821e-06 405 566.181818181818 659 9.81001610234199e-08 154 1.23469406060782 -1.00368759963302 -1 6.62897480376513 401 659 697 674 366 271 154 901 507 854 744 737 M19082 GO_MONOSACCHARIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BINDING.html Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 60/85 Gene Ontology MF GO:0048029 5.0500703156678e-06 8.01763740837981e-06 760 656.181818181818 661 4.59098355279393e-07 426 1.35176766006228 -1.03354570174935 -1 6.62397230013838 541 661 620 749 573 560 426 759 786 785 758 738 M18309 GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIPEPTIDYL_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. 12/15 Gene Ontology MF GO:0008239 0.000145990355673993 0.000162328626525595 690 664.181818181818 662 1.32727313077273e-05 408 1.98762342740956 -2.4580659165101 -1 7.24830991817797 688 452 408 623 825 662 613 892 790 616 737 739 M18908 GO_POLY_A_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_RNA_BINDING.html Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. 1309/1614 Gene Ontology MF GO:0044822 1.10397771571487e-05 1.54373619973054e-05 920 715.545454545455 662 1.1039832002038e-06 379 1.11067331538025 1.16155981481344 1 5.12595720927546 379 919 896 919 662 574 611 593 751 920 647 740 M18376 GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS.html Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). 19/20 Gene Ontology MF GO:0016780 3.45772715991993e-05 4.22611097323547e-05 315 568.636363636364 664 3.14343773273792e-06 237 0.862810443612796 -1.05472152462268 -1 3.60338821982494 314 681 664 717 748 515 470 237 802 781 326 741 M19186 GO_PHOSPHATASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_REGULATOR_ACTIVITY.html Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 78/92 Gene Ontology MF GO:0019208 3.45526639205751e-06 5.94537457404309e-06 850 688.454545454545 664 3.14115619893331e-07 529 1.46759467910102 -1.26713686021093 -1 7.38125306826454 850 613 638 718 529 765 664 554 587 794 861 742 M17853 GO_POLYUBIQUITIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYUBIQUITIN_BINDING.html Interacting selectively and non-covalently with a polymer of ubiqutin. 44/46 Gene Ontology MF GO:0031593 1.335433130467e-06 2.98774869867194e-06 595 615.545454545455 665 1.21403085554156e-07 208 1.33850388289555 -1.45205576371746 -1 7.11492577258074 594 621 665 672 398 746 695 777 208 802 593 743 M18040 GO_S_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. 25/29 Gene Ontology MF GO:0016417 0.000894720966043282 0.000950255370832175 430 633.636363636364 665 8.13713680575482e-05 351 1.19464128063994 -0.951710626522413 -1 3.44473704197301 430 892 681 825 863 537 395 351 665 720 611 744 M17900 GO_QUINONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_BINDING.html Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. 14/20 Gene Ontology MF GO:0048038 1.45993894496078e-05 1.96358600457607e-05 895 610.909090909091 666 1.32722603030122e-06 90 2.62498732945083 -3.01520874831961 -1 11.9261484733427 894 512 350 469 677 783 777 649 90 666 853 745 M18113 GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATED_AMINO_ACID_BINDING.html Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein. 33/37 Gene Ontology MF GO:0045309 1.31292493784194e-05 1.78929593298814e-05 700 676.363636363636 667 1.19357524839472e-06 499 1.31063224888415 -1.25814577020682 -1 5.97752726815608 735 550 606 499 667 874 919 699 573 698 620 746 M18154 GO_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_BINDING.html Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. 174/227 Gene Ontology MF GO:0003729 1.34911028297074e-05 1.83551756236313e-05 275 668.818181818182 668 1.22647141474275e-06 275 1.22276518944529 1.39065727144872 1 5.55984564546311 275 845 795 917 668 486 529 584 765 906 587 747 M19222 GO_SNORNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_BINDING.html Interacting selectively and non-covalently with small nucleolar RNA. 28/31 Gene Ontology MF GO:0030515 0.00743747320314343 0.00769566096271504 890 560.636363636364 668 0.000678430590338361 114 1.18232613112132 1.15964723965441 1 2.3670173556633 114 887 668 895 888 230 239 373 683 795 395 748 M18687 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. 34/37 Gene Ontology MF GO:0032266 0.000126753372152713 0.000141791907831849 880 643.545454545455 669 1.15236977871644e-05 214 1.59163087814376 2.36539865278127 1 5.88361174646742 566 879 593 453 818 690 880 669 214 812 505 749 M18313 GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTRADIOL_17_BETA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. 9/21 Gene Ontology MF GO:0004303 3.2303505918939e-06 5.64242712081278e-06 650 640.727272727273 670 3.23035528772772e-07 265 1.00847091867455 -0.868268946604531 -1 5.07656439983664 648 525 843 671 532 801 785 265 670 699 609 750 M17939 GO_METHYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. 59/67 Gene Ontology MF GO:0035064 1.02111696068567e-05 1.44267900867517e-05 490 635.727272727273 673 9.28292454700294e-07 358 1.02498070057803 1.24795133780593 1 4.7553226406495 490 790 737 801 647 412 673 430 810 845 358 751 M18541 GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. 19/25 Gene Ontology MF GO:0015035 1.56016569653776e-06 3.32164309585458e-06 530 664.727272727273 673 1.41833345723243e-07 418 0.778994897205548 0.840606501428038 1 4.08234110409395 529 579 699 762 418 673 684 655 855 833 625 752 M18975 GO_DOUBLE_STRANDED_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_RNA_BINDING.html Interacting selectively and non-covalently with double-stranded RNA. 109/150 Gene Ontology MF GO:0003725 7.25586450880042e-07 2.10830780067031e-06 760 617.909090909091 674 6.59624263806625e-08 229 2.06223021419143 -2.1445703156528 -1 11.2954416804056 756 850 464 427 300 872 831 615 229 674 779 753 M18666 GO_DEOXYRIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. 69/77 Gene Ontology MF GO:0004536 3.53343091573018e-06 6.04609290024942e-06 355 569.727272727273 675 3.21221508254897e-07 209 1.25127053068711 1.27903506849832 1 6.27603882751893 352 730 717 795 531 260 209 675 779 705 514 754 M18804 GO_RETINOID_X_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOID_X_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a retinoid X receptor. 22/25 Gene Ontology MF GO:0046965 0.00400046974972456 0.00416265095579447 425 625.818181818182 676 0.000364342068931511 177 0.931312850209727 -1.04232557894591 -1 2.09349199537923 423 751 676 610 882 322 177 735 897 769 642 755 M18629 GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. 11/22 Gene Ontology MF GO:0015106 0.0012177435703611 0.00128740853434057 675 639 678 0.000110765285303972 339 2.18791140446797 -1.73455647400617 -1 6.0761553702317 674 767 416 678 868 688 555 339 777 583 684 756 M19023 GO_C_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. 14/20 Gene Ontology MF GO:0016408 0.000133173309732311 0.000148613693469391 845 650.909090909091 678 1.21073974398615e-05 137 1.56463287860497 -1.92464814080768 -1 5.75188237658974 842 513 537 426 820 826 850 863 137 668 678 757 M19038 GO_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. 282/602 Gene Ontology MF GO:0004175 5.51140846973744e-07 1.87669856292307e-06 885 573.545454545455 679 5.01037259131643e-08 97 2.28333133659473 -2.41114558901094 -1 12.6244753634481 679 715 97 736 251 884 827 884 423 328 485 758 M19189 GO_PROTEIN_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHANNEL_ACTIVITY.html Enables the energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel. 10/12 Gene Ontology MF GO:0015266 0.00874972296510228 0.00902315180776173 890 681.363636363636 679 0.000798610627267475 337 0.761684998976439 0.6601188593673 1 1.45366025354712 337 912 647 894 890 524 396 536 887 793 679 759 M18903 GO_ZINC_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_BINDING.html Interacting selectively and non-covalently with zinc (Zn) ions. 1019/1372 Gene Ontology MF GO:0008270 9.37415210667848e-07 2.41273441408661e-06 465 663.181818181818 682 9.37415606104356e-08 359 1.61687460999906 -1.45902464417365 -1 8.75199704014477 464 775 895 866 359 527 514 830 534 849 682 760 M17950 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of hydrogen ions from one side of a membrane to the other. 80/114 Gene Ontology MF GO:0015078 2.30822834626844e-06 4.40661775196702e-06 425 642.090909090909 684 2.09839160732086e-07 422 1.36169133994832 -1.68121827574472 -1 7.01629626562479 422 725 684 822 474 846 800 461 431 841 557 761 M18096 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_BINDING.html Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. 15/20 Gene Ontology MF GO:0030169 0.000319476859656807 0.000346474904134848 630 636.545454545455 684 2.90475693166908e-05 294 2.18048540470669 -1.95107883806902 -1 7.26080877036672 630 822 398 892 844 519 301 294 848 684 770 762 M18298 GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 131/168 Gene Ontology MF GO:0001076 3.66148951708235e-07 1.69370198541451e-06 815 685.181818181818 684 3.32862738769919e-08 173 1.58272165334093 1.5402411399027 1 8.8018140384847 812 609 641 684 173 704 847 916 669 576 906 763 M19029 GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY.html Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. 267/338 Gene Ontology MF GO:0003714 1.15972599838144e-05 1.60417188997673e-05 620 706.181818181818 684 1.05430191991006e-06 608 1.45040863845833 -1.47246645458128 -1 6.68778712771985 620 841 743 803 654 684 615 608 726 797 677 764 M18627 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_S_S_BONDS.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. 19/22 Gene Ontology MF GO:0016864 0.000372981360036347 0.000403081610144544 680 736 685 3.39131462893832e-05 640 0.943703172883395 0.834000031884829 1 3.05011922389194 676 685 678 679 847 644 640 849 718 783 897 765 M18793 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the insulin-like growth factor receptor. 17/26 Gene Ontology MF GO:0005159 1.78700967266926e-05 2.36561165837592e-05 695 665.727272727273 687 1.62456744391373e-06 248 1.39469026500173 -0.788758647738864 -1 6.20051771914753 694 580 474 637 687 912 852 704 875 660 248 766 M18062 GO_PRENYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRENYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). 16/16 Gene Ontology MF GO:0004659 0.000890598315179846 0.000946965297153254 280 531.181818181818 689 8.09962772135552e-05 89 0.954419693056416 -1.01701053776856 -1 2.74204890212209 280 823 689 831 912 139 89 184 868 803 225 767 M18766 GO_SINGLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with single-stranded DNA. 96/108 Gene Ontology MF GO:0003697 1.84001715953728e-05 2.42535785365542e-05 785 499.181818181818 689 1.67275686281402e-06 39 1.17214914590109 1.13444242471132 1 5.18977915549195 39 785 774 804 689 71 83 406 781 757 302 768 M18042 GO_PROTEASOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_BINDING.html Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation. 18/20 Gene Ontology MF GO:0070628 2.67441028944083e-05 3.35299200467209e-05 520 635.272727272727 690 2.43131163747565e-06 411 1.52931640929762 1.61877010891944 1 6.57982988900651 519 814 532 642 727 411 418 690 767 772 696 769 M18300 GO_AMINOACYL_TRNA_EDITING_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOACYL_TRNA_EDITING_ACTIVITY.html The hydrolysis of an incorrectly aminoacylated tRNA. 11/11 Gene Ontology MF GO:0002161 0.000441845592919057 0.000476388947324631 410 644.727272727273 691 4.01758506967169e-05 150 0.578036811134862 0.531059560913572 1 1.80559815795778 408 705 672 643 849 343 150 802 917 912 691 770 M19000 GO_ANGIOTENSIN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOTENSIN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an angiotensin receptor. 18/21 Gene Ontology MF GO:0031701 2.03960856628749e-05 2.63949343872499e-05 895 670.272727272727 691 1.85420679603449e-06 206 2.25744843382764 -1.5356704008851 -1 9.96709597367909 893 691 391 636 704 901 778 206 644 605 924 771 M17991 GO_FATTY_ACYL_COA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_BINDING.html Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. 31/35 Gene Ontology MF GO:0000062 1.51390051652944e-06 3.26070880483265e-06 670 683.727272727273 692 1.37627414390982e-07 414 1.36234566931944 -1.10330116236413 -1 7.19250432014381 669 799 658 759 414 692 743 733 653 682 719 772 M18433 GO_TELOMERASE_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_RNA_BINDING.html Interacting selectively and non-covalently with the telomerase RNA template. 15/16 Gene Ontology MF GO:0070034 5.5013839379884e-05 6.47551434229462e-05 695 480.363636363636 692 5.00138319273667e-06 5 0.590596981528118 0.616275306300082 1 2.34248277938572 65 692 694 790 805 23 5 207 879 917 207 773 M18447 GO_CHROMATIN_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DNA_BINDING.html Interacting selectively and non-covalently with DNA that is assembled into chromatin. 97/136 Gene Ontology MF GO:0031490 3.1120574037812e-06 5.49816642656563e-06 860 696.090909090909 692 2.82914709637979e-07 455 1.46102359849329 1.40650494713693 1 7.3960710755481 723 612 566 455 513 914 807 857 662 692 856 774 M17922 GO_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. 33/35 Gene Ontology MF GO:0034061 4.26317650036354e-05 5.12246435154215e-05 310 573 695 3.87569010432617e-06 285 1.15345478072336 1.23527866518272 1 4.74287433965795 309 800 695 870 762 292 381 330 849 730 285 775 M18885 GO_ENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_BINDING.html Interacting selectively and non-covalently with any enzyme. 1910/2452 Gene Ontology MF GO:0019899 3.11762246916084e-07 1.69329794462269e-06 725 581.727272727273 695 3.11762290654157e-08 158 1.69583126083594 -1.59365420433925 -1 9.43506193944155 725 222 893 612 158 818 717 806 433 320 695 776 M18239 GO_ANDROGEN_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_BINDING.html Interacting selectively and non-covalently with an androgen receptor. 55/64 Gene Ontology MF GO:0050681 8.7612760134527e-06 1.26887445712074e-05 735 623.181818181818 696 7.9648280950336e-07 125 1.25831500912309 1.38229790448318 1 5.91880811808877 732 733 696 125 630 572 340 920 469 744 894 777 M19100 GO_CARBON_OXYGEN_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_OXYGEN_LYASE_ACTIVITY.html Catalysis of the breakage of a carbon-oxygen bond. 65/77 Gene Ontology MF GO:0016835 1.285276129253e-06 2.91077241036709e-06 840 658.454545454545 696 1.16843352739367e-07 393 1.52312216930735 -1.66433727940741 -1 8.12084758105821 837 484 533 696 393 830 907 763 414 529 857 778 M19163 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_NAD_P_H_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_OF_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. 27/82 Gene Ontology MF GO:0016709 5.89641969979462e-06 9.05031860898709e-06 790 609.636363636364 697 5.3603959121669e-07 153 2.54257947655836 -2.98616469593144 -1 12.3794440498578 788 560 153 697 595 907 921 331 799 213 742 779 M19153 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the platelet-derived growth factor receptor. 17/18 Gene Ontology MF GO:0005161 4.44941550730806e-05 5.31857688066319e-05 805 613.181818181818 698 4.04500499779627e-06 157 1.91872733021028 -1.940071980699 -1 7.89685775622756 801 157 322 542 765 807 877 692 754 330 698 780 M19179 GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_ACTIVITY_H3_K14_SPECIFIC_.html Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. 13/15 Gene Ontology MF GO:0031078 4.2167120514336e-06 6.93281483189439e-06 840 664.090909090909 703 3.83338193961246e-07 246 0.912094196359491 -0.938019254110811 -1 4.50687132366346 839 449 622 246 550 831 553 880 778 703 854 781 M19220 GO_COENZYME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BINDING.html Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 172/214 Gene Ontology MF GO:0050662 1.27659876776379e-06 2.8982242295178e-06 660 708.727272727273 705 1.16054500776284e-07 392 1.53963049614692 -1.5939609442613 -1 8.21228157856484 895 657 675 705 392 785 759 779 659 657 833 782 M18671 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_SINGLE_DONORS_WITH_INCORPORATION_OF_MOLECULAR_OXYGEN.html Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. 15/29 Gene Ontology MF GO:0016701 2.16859587202503e-05 2.78690206641325e-05 880 592.181818181818 706 1.97147022610935e-06 214 2.58498865152526 -2.96889799417485 -1 11.3623150215713 878 355 214 516 709 748 924 878 329 257 706 783 M18115 GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING.html Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. 689/977 Gene Ontology MF GO:0001067 8.071157975306e-07 2.23553682083004e-06 750 654 707 8.07116090676909e-08 335 1.74554346627594 -1.65934384717536 -1 9.5090648247209 616 712 826 707 335 732 601 749 581 587 748 784 M18112 GO_POLY_PYRIMIDINE_TRACT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_PYRIMIDINE_TRACT_BINDING.html Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule. 21/26 Gene Ontology MF GO:0008187 7.69146508943587e-06 1.12451166813904e-05 775 707 709 6.99226543623293e-07 565 1.12268077184965 1.39589653884965 1 5.33181656688385 689 636 578 709 625 774 772 860 565 761 808 785 M18307 GO_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids. 189/224 Gene Ontology MF GO:0004518 8.3048498878882e-07 2.26673289780166e-06 520 650.181818181818 709 7.54986638446731e-08 310 1.30375156142804 1.18221775319699 1 7.08038267836806 518 842 765 907 323 310 337 912 672 857 709 786 M18064 GO_LYSINE_ACETYLATED_HISTONE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_ACETYLATED_HISTONE_BINDING.html Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation. 21/21 Gene Ontology MF GO:0070577 0.000764724765300764 0.000815000787932994 850 724.181818181818 710 6.95446104288221e-05 568 0.860491828766264 1.07135814832429 1 2.52100310625756 673 683 710 568 862 772 848 591 850 811 598 787 M18511 GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BINDING.html Interacting selectively and non-covalently with any part of the small ribosomal subunit. 19/22 Gene Ontology MF GO:0043024 0.00134669190095745 0.00142048323799621 710 751.636363636364 710 0.000122501542021394 659 0.828866793924071 -0.949836443775172 -1 2.23231279679209 710 687 691 681 869 806 769 659 904 782 710 788 M18769 GO_RIBONUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. 1594/1976 Gene Ontology MF GO:0032553 5.933306370014e-07 1.92595208502953e-06 755 670.090909090909 710 5.93330795420018e-08 286 1.67318940909102 1.77507764822961 1 9.21760386726969 752 603 882 691 286 665 823 778 429 710 752 789 M18283 GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES.html Catalysis of the hydrolysis of any acid anhydride. 741/890 Gene Ontology MF GO:0016817 7.52609068494428e-07 2.13316189965905e-06 680 668.727272727273 711 7.52609323383734e-08 322 1.61727833447837 1.7323919810819 1 8.83808774409028 680 711 841 784 322 448 619 889 459 829 774 790 M18872 GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of a macromolecule from one side of the membrane to the other. 22/35 Gene Ontology MF GO:0022884 0.00343750611692338 0.00358493865918421 620 742.181818181818 711 0.000312989909870148 517 1.36764057553102 0.652432617324906 1 3.18695068768124 627 898 618 711 880 619 517 921 652 851 870 791 M18718 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase. 325/400 Gene Ontology MF GO:0044389 1.97564728427443e-06 3.97712002324525e-06 755 665.454545454545 714 1.79604459859125e-07 446 1.62694288766505 1.7432009163944 1 8.46436160557055 731 714 682 728 446 751 604 701 488 751 724 792 M18297 GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. 75/95 Gene Ontology MF GO:0004722 2.32581614378562e-06 4.43103941620188e-06 765 646.181818181818 715 2.11438054783351e-07 177 1.65685848363304 1.93068312507139 1 8.54562268080863 764 788 598 673 475 728 715 812 177 817 561 793 M19180 GO_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_BINDING.html Interacting selectively and non-covalently with an RNA molecule or a portion thereof. 1684/2094 Gene Ontology MF GO:0003723 7.08087860983793e-06 1.05247236733609e-05 920 747.090909090909 715 7.08090117241796e-07 532 1.19120108833598 1.21322690534105 1 5.69391140022168 532 918 922 920 626 623 657 653 729 923 715 794 M18039 GO_ATPASE_ACTIVITY_COUPLED http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_ACTIVITY_COUPLED.html Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane. 284/347 Gene Ontology MF GO:0042623 2.33666639115981e-06 4.44255091652606e-06 720 680.727272727273 716 2.12424442998741e-07 456 1.58926576169221 1.70230518509794 1 8.1929471816595 920 716 718 456 476 639 750 668 476 787 882 795 M18994 GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. 70/84 Gene Ontology MF GO:0050660 2.36765892858971e-06 4.47720935793015e-06 730 701.909090909091 719 2.15241952426223e-07 479 1.66934756318727 -1.70054742305152 -1 8.60317719376524 727 660 596 817 479 719 901 683 775 562 802 796 M19117 GO_RECEPTOR_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INHIBITOR_ACTIVITY.html The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. 8/14 Gene Ontology MF GO:0030547 1.35901421556776e-06 3.00413668704452e-06 905 653.181818181818 719 1.35901504668231e-07 203 2.21295421534356 1.54130359725018 1 11.7950950395989 904 203 917 475 411 813 892 719 641 336 874 797 M18581 GO_IDENTICAL_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_IDENTICAL_PROTEIN_BINDING.html Interacting selectively and non-covalently with an identical protein or proteins. 1258/1724 Gene Ontology MF GO:0042802 2.87153832433488e-07 1.66268825097163e-06 890 556.272727272727 720 2.87153869539291e-08 46 1.94712248489694 2.11402690397976 1 10.8565315911789 886 225 868 296 139 720 884 755 377 46 923 798 M18462 GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDO_KETO_REDUCTASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. 22/35 Gene Ontology MF GO:0004033 7.08482481042259e-06 1.05247236733609e-05 635 708.272727272727 722 6.44077056937958e-07 473 2.03976783347795 1.67875258550084 1 9.790445292408 910 750 473 722 615 634 513 898 793 632 851 799 M19169 GO_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. 82/97 Gene Ontology MF GO:0008080 1.43527977655076e-05 1.94172549565579e-05 720 752 722 1.30480830945463e-06 650 1.01499040650796 0.848727536161478 1 4.58141968803194 717 789 778 855 672 795 709 650 722 874 711 800 M17852 GO_5_3_EXONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_5_3_EXONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. 11/12 Gene Ontology MF GO:0008409 0.000126117037604865 0.000141251082117449 820 645.636363636364 723 1.1465842541922e-05 341 1.02745026171485 -0.785006498610004 -1 3.7796135207756 485 768 632 723 817 347 341 756 818 808 607 801 M18047 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ALKYL_OR_ARYL_OTHER_THAN_METHYL_GROUPS.html Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). 52/68 Gene Ontology MF GO:0016765 2.1511200593884e-05 2.76829378116279e-05 885 692.545454545455 723 1.95558281176158e-06 428 1.54063770828176 1.26889769785629 1 6.75330305213716 881 734 611 814 708 689 804 448 428 723 778 802 M18339 GO_EXORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXORIBONUCLEASE_ACTIVITY.html Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. 34/34 Gene Ontology MF GO:0004532 1.21402537550444e-07 1.58112794444989e-06 690 685.545454545455 724 1.10365949317997e-08 20 0.911345816755413 0.792326293284247 1 5.0705060855202 686 878 724 902 20 569 434 858 696 875 899 803 M18464 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS.html Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). 182/229 Gene Ontology MF GO:0016747 5.27984717073446e-06 8.32521977091919e-06 565 693.181818181818 724 4.79987258367588e-07 531 1.33163687872075 -1.37877329035432 -1 6.50336773312879 565 843 767 899 579 724 773 531 555 831 558 804 M18479 GO_TRANSITION_METAL_ION_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_BINDING.html Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 1214/1709 Gene Ontology MF GO:0046914 6.42622719866222e-07 1.95615192380487e-06 525 662.454545454545 725 6.42622905700079e-08 295 1.74883490128834 -1.58461278155601 -1 9.62543893120712 526 774 863 885 295 538 525 899 525 725 732 805 M17926 GO_UBIQUITIN_LIKE_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_BINDING.html Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. 138/151 Gene Ontology MF GO:0032182 5.13036675077149e-07 1.85900348145602e-06 590 673.454545454545 726 4.66397086105968e-08 236 1.37427711405875 -1.2679070942517 -1 7.58124127181253 590 780 726 835 236 709 598 762 559 846 767 806 M18925 GO_RETINOL_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_BINDING.html Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. 8/13 Gene Ontology MF GO:0019841 1.09450895038534e-05 1.53463773923528e-05 730 682.090909090909 726 1.094514341197e-06 218 2.16425666871815 2.04070134434154 1 10.0476281427335 829 468 898 587 659 730 776 726 705 218 907 807 M18772 GO_RETINOIC_ACID_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. 35/135 Gene Ontology MF GO:0042974 0.000108691061330371 0.00012292599837119 825 654.909090909091 727 9.88149378061219e-06 280 0.921580810780274 -0.958263945669625 -1 3.43825141828056 494 798 727 510 808 383 280 694 867 821 822 808 M18730 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. 22/30 Gene Ontology MF GO:0016628 0.000112931441296035 0.000127099454028668 520 676.090909090909 729 1.02670217057158e-05 422 1.15604852233535 -1.33544570067495 -1 4.31118218639583 520 747 597 789 811 493 422 837 826 729 666 809 M19150 GO_ISOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOMERASE_ACTIVITY.html Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. 142/174 Gene Ontology MF GO:0016853 4.98495396675406e-07 1.84352199509307e-06 730 719 730 4.53177736026294e-08 226 1.31275650164872 1.33355870905638 1 7.24394569333103 730 718 755 898 226 693 727 846 691 839 786 810 M19049 GO_THYROID_HORMONE_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_RECEPTOR_BINDING.html Interacting selectively and non-covalently with a thyroid hormone receptor. 38/42 Gene Ontology MF GO:0046966 0.000227199899146682 0.000249622719157591 275 559.181818181818 731 2.06566696438589e-05 87 1.10414153106084 -0.977414967611515 -1 3.80115946654292 272 797 731 770 835 208 87 501 792 814 344 811 M19204 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 873/1070 Gene Ontology MF GO:0016772 4.18530991762001e-07 1.70429971387201e-06 845 681.363636363636 731 4.18531070587707e-08 218 1.66970637234409 1.80536127025018 1 9.28428311847364 845 650 923 779 218 797 885 567 504 596 731 812 M18055 GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_CONJUGATING_ENZYME_ACTIVITY.html Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. 29/39 Gene Ontology MF GO:0061650 4.63813143308877e-05 5.51561575826773e-05 415 607.454545454545 733 4.21657201726316e-06 205 0.779709599314084 0.834380334951689 1 3.16341301609221 205 808 733 847 767 334 415 446 854 860 413 813 M18729 GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. 204/232 Gene Ontology MF GO:0061659 7.09946402696498e-07 2.07695764029584e-06 720 709.363636363636 733 6.45406028907611e-08 296 1.3415096050241 1.37187909210874 1 7.33648455431776 720 717 766 901 296 855 787 664 511 853 733 814 M18126 GO_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 194/233 Gene Ontology MF GO:0019207 2.33084718479385e-07 1.65381926038186e-06 480 625.090909090909 734 2.11895221067414e-08 80 1.89459142234186 2.09293112906282 1 10.566372870777 906 476 320 781 80 886 849 734 477 489 878 815 M18570 GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. 69/83 Gene Ontology MF GO:0004843 0.000623407440568797 0.000666699623941631 245 639.090909090909 734 5.66894694353658e-05 242 1.31232438997532 -1.34766015524772 -1 3.98554831663485 242 862 734 909 858 489 307 444 758 873 554 816 M18261 GO_VITAMIN_D_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_RECEPTOR_BINDING.html Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. 19/22 Gene Ontology MF GO:0042809 3.21854458292248e-06 5.63245302011433e-06 655 722.090909090909 735 2.92595390143797e-07 519 1.30077640022104 -1.06463612951663 -1 6.56541752395086 760 895 652 827 519 750 843 576 732 735 654 817 M18362 GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_DEHYDROGENASE_NADP_ACTIVITY.html Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. 19/29 Gene Ontology MF GO:0008106 2.85892070465366e-05 3.54582916926172e-05 915 717.181818181818 735 2.59905259752109e-06 493 1.84189817946211 1.11037312560361 1 7.89291402029107 911 815 506 792 735 602 493 661 847 693 834 818 M18813 GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_NITROGEN_BONDS.html Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 54/63 Gene Ontology MF GO:0016879 4.53107351067428e-06 7.31942644031998e-06 815 718.727272727273 735 4.11916622073131e-07 487 1.34354924943506 -1.31848938596119 -1 6.63491460629882 815 487 623 782 560 735 739 923 645 711 886 819 M18051 GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHATASE_ACTIVITY.html Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. 8/11 Gene Ontology MF GO:0019203 0.017923715967806 0.0183000149770749 885 691 736 0.00180699454902436 318 2.24897076278382 -2.40846653500784 -1 3.73306568012603 882 832 816 716 924 648 318 405 743 581 736 820 M18482 GO_TELOMERIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERIC_DNA_BINDING.html Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. 35/38 Gene Ontology MF GO:0042162 3.72386430502538e-05 4.53340002350916e-05 230 636.727272727273 736 3.38538849008086e-06 226 1.03096822701033 1.07020742037323 1 4.28624781932815 226 889 736 856 751 427 390 566 835 881 447 821 M18626 GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_GENERATING_NADPH_OXIDASE_ACTIVITY.html Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. 4/8 Gene Ontology MF GO:0016175 1.86950770200702e-06 3.79653871792194e-06 905 649.909090909091 738 1.86950927478545e-07 190 1.87809043347622 -1.46343705982854 -1 9.8165000322193 903 472 871 532 454 852 866 477 794 190 738 822 M18966 GO_PROTEIN_DOMAIN_SPECIFIC_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DOMAIN_SPECIFIC_BINDING.html Interacting selectively and non-covalently with a specific domain of a protein. 704/931 Gene Ontology MF GO:0019904 4.1206749797406e-07 1.70429971387201e-06 905 565.363636363636 738 4.12067574383911e-08 134 1.85250162304632 1.99842180276022 1 10.3069127638329 902 236 902 134 214 868 738 803 338 191 893 823 M18128 GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDONUCLEASE_ACTIVITY_ACTIVE_WITH_EITHER_RIBO_OR_DEOXYRIBONUCLEIC_ACIDS_AND_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 36/37 Gene Ontology MF GO:0016893 2.91081455816722e-06 5.22061771450319e-06 885 711 740 2.6461985540599e-07 401 0.861029536845644 0.961856804688254 1 4.35424106200206 682 883 748 773 504 626 401 706 876 882 740 824 M18028 GO_MIRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIRNA_BINDING.html Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. 15/25 Gene Ontology MF GO:0035198 0.0181211617038876 0.0184811847840973 835 673.363636363636 741 0.00166110618162755 300 2.11123700656064 1.63748523796801 1 3.49220759792576 388 828 544 833 897 520 300 741 736 788 832 825 M18692 GO_N_ACYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. 91/116 Gene Ontology MF GO:0016410 6.37895854867312e-06 9.61526541431316e-06 855 745.909090909091 741 5.79907004064389e-07 602 1.05848601258104 -1.11770046655054 -1 5.0935085935049 701 855 776 854 602 762 720 652 741 871 671 826 M19012 GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CARBOXY_TERMINAL_DOMAIN_KINASE_ACTIVITY.html Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. 19/20 Gene Ontology MF GO:0008353 4.1267629072026e-05 4.96501162272813e-05 890 736.090909090909 741 3.75167301737153e-06 449 0.989818088676083 -0.771563325985222 -1 4.07498777280064 887 686 679 449 760 739 741 804 633 834 885 827 M18244 GO_RNA_CAP_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING.html Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. 18/18 Gene Ontology MF GO:0000339 0.000698135338642578 0.00074489267079185 565 668.363636363636 743 6.34869981242892e-05 184 0.714198904808257 -0.826201403698343 -1 2.10981993457204 564 821 730 772 861 340 184 517 909 911 743 828 M19126 GO_OPSONIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPSONIN_BINDING.html Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. 16/21 Gene Ontology MF GO:0001846 0.00214221497205117 0.00224422520881551 580 724.545454545455 743 0.000194936706166523 517 1.69788726748143 -1.54589766912888 -1 4.30516114857887 579 905 540 767 875 834 730 616 864 743 517 829 M19065 GO_TBP_CLASS_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TBP_CLASS_PROTEIN_BINDING.html Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). 20/25 Gene Ontology MF GO:0017025 0.00801385107080196 0.00828277224767451 200 599.636363636364 744 0.000731199322276137 70 0.670495802404501 0.737062983507358 1 1.29701533909714 199 902 744 851 889 245 70 453 911 869 463 830 M18991 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_SULFUR_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 43/50 Gene Ontology MF GO:0016667 2.644717146027e-07 1.66268825097163e-06 755 644 745 2.40428860360017e-08 105 1.12598765632391 -1.04246524346056 -1 6.25422635836101 753 409 688 748 105 790 793 651 640 762 745 831 M18465 GO_MOLECULAR_FUNCTION_REGULATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLECULAR_FUNCTION_REGULATOR.html A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators. 1191/1627 Gene Ontology MF GO:0098772 1.80494533896201e-07 1.65381926038186e-06 855 546 747 1.80494548556427e-08 31 1.98185477082874 -1.79866581989267 -1 11.0556639935841 854 226 860 295 69 911 747 834 411 31 768 832 M17871 GO_MHC_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the major histocompatibility complex. 23/33 Gene Ontology MF GO:0023023 5.84020419043382e-06 8.99391445326808e-06 810 684.181818181818 748 5.30929063101906e-07 424 2.23042777156738 -2.67610739172104 -1 10.8585329813488 808 748 424 444 591 916 899 817 783 447 649 833 M17932 GO_NARROW_PORE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NARROW_PORE_CHANNEL_ACTIVITY.html Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. 8/17 Gene Ontology MF GO:0022842 8.44039680483706e-08 1.36249035098998e-06 750 498.636363636364 748 8.4403971254184e-09 11 2.89999122849158 -2.48793539539645 -1 16.4403971258318 828 188 806 105 11 881 749 748 19 332 818 834 M18505 GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with the class II major histocompatibility complex. 23/28 Gene Ontology MF GO:0023026 5.84020419043382e-06 8.99391445326808e-06 810 685.636363636364 749 5.30929063101906e-07 425 2.23042777156738 -2.67610739172104 -1 10.8585329813488 809 749 425 445 592 917 900 820 784 451 650 835 M17999 GO_ACID_AMINO_ACID_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_AMINO_ACID_LIGASE_ACTIVITY.html Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 21/27 Gene Ontology MF GO:0016881 2.01643545161658e-06 4.02298873906755e-06 875 712.363636363636 752 1.83312481800563e-07 450 1.38667682142947 -1.13393847325656 -1 7.19927514725994 874 752 600 826 450 699 576 786 823 679 771 836 M18399 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ACYL_GROUPS.html Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). 210/262 Gene Ontology MF GO:0016746 5.19023353730584e-06 8.21194484327156e-06 535 710.181818181818 752 4.71840525648181e-07 514 1.417432409015 -1.50683638061861 -1 6.93420404461644 535 922 762 896 577 752 833 514 655 807 559 837 M18829 GO_ENZYME_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_REGULATOR_ACTIVITY.html Binds to and modulates the activity of an enzyme. 872/1178 Gene Ontology MF GO:0030234 1.90571518959155e-07 1.65381926038186e-06 855 562.636363636364 753 1.90571535302034e-08 62 1.88863558620403 2.08295904286733 1 10.5329781202699 853 230 885 385 62 753 789 772 427 120 913 838 M19020 GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY.html Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. 90/118 Gene Ontology MF GO:0019783 0.000194031797242852 0.000214456196952626 860 618.363636363636 753 1.7640810203384e-05 158 1.2805189851445 -1.40800748839293 -1 4.49932041082716 158 857 759 857 830 449 328 420 753 892 499 839 M18739 GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. 9/18 Gene Ontology MF GO:0015101 0.000106104303573384 0.000120147520222803 755 731 754 1.06109370069309e-05 508 1.72353643659322 1.96715011372042 1 6.49615800241042 754 707 877 667 814 841 729 787 804 508 553 840 M19013 GO_ENDORIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. 49/63 Gene Ontology MF GO:0004521 1.93216296989606e-06 3.91517233373676e-06 875 678.363636363636 754 1.75651333348333e-07 369 1.40561184912159 1.14544175419116 1 7.31443848467414 790 793 635 766 442 875 873 369 529 754 636 841 M17942 GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NTP_DEPENDENT_HELICASE_ACTIVITY.html Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix. 94/102 Gene Ontology MF GO:0070035 0.000129656965960421 0.000144864614930386 725 765.181818181818 755 1.17876916292947e-05 676 1.01084901855541 -0.810151379816252 -1 3.70687219552631 722 856 790 733 819 676 686 758 725 897 755 842 M17898 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 55/65 Gene Ontology MF GO:0016627 6.59938413414844e-05 7.70901509475747e-05 450 739 757 5.99962009592025e-06 448 0.999273782338825 -1.09199012061217 -1 3.92927929544636 448 866 757 906 782 605 702 737 839 859 628 843 M18057 GO_C2H2_ZINC_FINGER_DOMAIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_C2H2_ZINC_FINGER_DOMAIN_BINDING.html Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. 16/22 Gene Ontology MF GO:0070742 4.00884857283054e-05 4.83573900952405e-05 700 734.181818181818 758 3.64447420371733e-06 392 1.56523242112056 1.75526635950975 1 6.49428070190355 916 697 562 680 758 873 870 392 851 696 781 844 M19207 GO_ACYL_COA_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. 17/19 Gene Ontology MF GO:0003995 0.00111658671048892 0.00118181686196079 760 672 758 0.000101559438660069 385 0.751815645087024 -0.684979496928794 -1 2.07777232941438 508 816 701 761 866 603 758 423 811 760 385 845 M18422 GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRUCTURAL_CONSTITUENT_OF_RIBOSOME.html The action of a molecule that contributes to the structural integrity of the ribosome. 210/311 Gene Ontology MF GO:0003735 9.85291115100563e-07 2.46144277069945e-06 365 704.181818181818 759 8.95719596702657e-08 353 0.823486694246168 -0.762164335655859 -1 4.42269446472124 363 844 798 918 353 703 565 623 905 915 759 846 M18208 GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOCYTOPLASMIC_TRANSPORTER_ACTIVITY.html Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. 26/29 Gene Ontology MF GO:0005487 0.0100164321763558 0.0103064402349139 910 601.363636363636 760 0.000914757186064022 125 0.794923157326705 0.747419701005044 1 1.47504781301725 214 894 760 911 908 248 125 359 906 815 475 847 M18809 GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_TRANSCRIPTION_MACHINERY_BINDING.html Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. 31/34 Gene Ontology MF GO:0001098 0.00104324852457556 0.00110672977808016 525 629.727272727273 761 9.48857787045554e-05 136 0.785157194082226 0.887454401044085 1 2.19414125848724 523 885 761 775 865 259 136 503 896 868 456 848 M18372 GO_HSP90_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HSP90_PROTEIN_BINDING.html Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. 31/38 Gene Ontology MF GO:0051879 9.9541924201935e-05 0.000113132519019173 805 738.272727272727 763 9.04967530853862e-06 531 1.32239561492091 1.05732546768156 1 5.00453024224218 885 803 631 763 804 718 820 825 713 628 531 849 M18723 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY.html Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. 28/32 Gene Ontology MF GO:0016538 0.000228287308192097 0.000250519563859261 650 761.181818181818 763 2.0755545483054e-05 638 1.11003488324885 1.33539244748014 1 3.82007414050576 813 672 646 638 836 763 646 917 797 755 890 850 M19077 GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. 52/59 Gene Ontology MF GO:0016278 4.30449275394407e-05 5.15869170511585e-05 480 680.090909090909 764 3.91325179765753e-06 243 0.781992175348451 -0.775696737216543 -1 3.19487464460973 480 871 780 859 764 428 243 722 886 865 583 851 M18081 GO_ADRENERGIC_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_ACTIVITY.html Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. 4/26 Gene Ontology MF GO:0004935 0.00472329383799279 0.00490373427674757 710 753.818181818182 767 0.000473336325000791 525 1.9408381915839 -2.82849003284613 -1 4.29034507976434 687 710 819 633 884 877 767 707 888 525 795 852 M18943 GO_METHYL_CPG_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYL_CPG_BINDING.html Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide. 16/19 Gene Ontology MF GO:0008327 0.000220825308113315 0.000242907838924647 770 720.545454545455 767 2.00770433272579e-05 500 1.14943847423654 0.98392553569251 1 3.97262898960324 846 516 592 500 834 839 706 767 770 640 916 853 M18557 GO_SUMO_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. 16/17 Gene Ontology MF GO:0019789 0.000385191642974959 0.000415790979099138 760 773.454545454545 768 3.50235546911695e-05 468 0.747955407494683 -0.673209306328935 -1 2.39590267137135 713 760 685 768 848 833 468 760 915 918 840 854 M18355 GO_PROTEIN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORTER_ACTIVITY.html Enables the directed movement of proteins into, out of or within a cell, or between cells. 102/119 Gene Ontology MF GO:0008565 3.65025491758126e-06 6.22294380783226e-06 475 699.909090909091 769 3.31841906738458e-07 471 1.06031202251959 1.2337893450324 1 5.29670997737729 471 854 786 915 533 498 515 814 769 891 653 855 M18531 GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. 64/69 Gene Ontology MF GO:0034212 0.000111283196268179 0.000125550272712818 725 770.090909090909 769 1.01171659759019e-05 643 0.816608728002037 0.645078627822052 1 3.03289329898021 721 865 783 776 810 769 643 740 756 907 701 856 M19071 GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COACTIVATOR_ACTIVITY.html Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. 316/384 Gene Ontology MF GO:0003713 1.0618321735398e-06 2.60247461101002e-06 650 695.727272727273 769 9.65302441849545e-08 362 1.45498680741621 1.55004128086279 1 7.82364154416176 649 779 769 771 362 632 902 835 621 852 481 857 M19004 GO_RIBONUCLEASE_P_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_P_ACTIVITY.html Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. 10/11 Gene Ontology MF GO:0004526 4.43951254582279e-06 7.21616244893055e-06 845 735.090909090909 770 4.03592864055267e-07 530 0.70210946785099 -0.649131812625199 -1 3.44438318292401 841 770 627 724 556 816 616 530 892 792 922 858 M17920 GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODEOXYRIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 10/10 Gene Ontology MF GO:0016888 9.46788715724832e-06 1.35423029927205e-05 810 719.454545454545 771 8.60720718486513e-07 504 1.28697052413525 1.51489823533166 1 6.01959871252861 810 771 612 829 639 707 504 573 902 790 777 859 M18087 GO_HISTONE_DEACETYLASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_BINDING.html Interacting selectively and non-covalently with the enzyme histone deacetylase. 124/158 Gene Ontology MF GO:0042826 1.83094835969807e-06 3.72642353383483e-06 865 723.727272727273 771 1.66449989409568e-07 437 1.49490869366465 -1.33563639176632 -1 7.8138302943525 852 610 633 571 437 880 864 859 771 622 862 860 M18791 GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_LYSINE_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. 42/46 Gene Ontology MF GO:0018024 5.3421986481233e-05 6.30420376866658e-05 775 687.454545454545 771 4.856662159685e-06 246 0.746604922522884 -0.778914992646662 -1 2.98467080104934 466 877 771 807 771 465 246 730 899 872 658 861 M18164 GO_TRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_BINDING.html Interacting selectively and non-covalently with transfer RNA. 46/47 Gene Ontology MF GO:0000049 2.5970306352155e-05 3.26204917268971e-05 910 782.090909090909 772 2.36096481168181e-06 588 0.807261163611824 -0.985241557168837 -1 3.45578160216302 588 875 772 910 724 768 819 752 907 870 618 862 M17873 GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIKE_PROTEIN_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. 403/483 Gene Ontology MF GO:0019787 7.37774709851484e-07 2.11053817926555e-06 715 715.090909090909 773 6.70704506605389e-08 306 1.33564756914895 1.35256100995166 1 7.29515540437297 714 778 793 873 306 799 669 773 590 877 694 863 M18152 GO_RNA_POLYMERASE_II_CORE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_CORE_BINDING.html Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. 21/22 Gene Ontology MF GO:0000993 0.00159416118517999 0.00167577353254415 785 724.727272727273 774 0.00014502886522259 201 0.491169551744266 -0.490790656375937 -1 1.26552165233149 785 896 750 774 872 371 201 729 920 910 764 864 M18657 GO_NADH_DEHYDROGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_ACTIVITY.html Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. 40/44 Gene Ontology MF GO:0003954 0.14492041280567 0.146505975309014 115 670.909090909091 777 0.0141319862472093 112 0.701899720384807 0.690815340207173 1 0.511098479889266 112 884 777 913 909 406 213 645 916 902 703 865 M19032 GO_RIBONUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEASE_ACTIVITY.html Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. 87/110 Gene Ontology MF GO:0004540 5.6146351853865e-07 1.88105729843001e-06 780 694.727272727273 778 5.10421510754721e-08 255 1.29054441463058 1.08475082779488 1 7.10946086636968 778 787 708 905 255 562 398 868 631 863 887 866 M18380 GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_LOCALIZATION_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. 18/25 Gene Ontology MF GO:0008139 0.546141693753755 0.549113084905843 690 776.909090909091 781 0.0692973825919563 634 1.75056668021044 1.04902567335251 1 0.38526687605641 690 907 693 837 914 781 708 634 749 823 810 867 M19225 GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a nucleotidyl group to a reactant. 128/136 Gene Ontology MF GO:0016779 4.54899942251218e-06 7.33555927818718e-06 875 776.454545454545 785 4.13546257148035e-07 561 1.16255413203478 1.06149098725444 1 5.73237838852739 873 848 785 876 561 675 634 750 776 895 868 868 M17885 GO_OLFACTORY_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_RECEPTOR_ACTIVITY.html Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. 2/849 Gene Ontology MF GO:0004984 1.81395938909741e-06 3.71066783908768e-06 815 714.2 785.5 2.01551205724523e-07 347 2.53745263073024 -1.22661200400953 -1 13.3072529498643 811 532 802 NA 463 891 704 915 908 347 769 869 M18142 GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_ACTIVITY_PRODUCING_5_PHOSPHOMONOESTERS.html Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 29/30 Gene Ontology MF GO:0016891 1.47425326517598e-05 1.979956420091e-05 740 775.818181818182 788 1.34023922223883e-06 586 0.762735462855736 0.823596447027402 1 3.42244155477444 793 890 740 846 678 738 586 718 878 879 788 870 M18722 GO_RNA_HELICASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_HELICASE_ACTIVITY.html Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. 62/69 Gene Ontology MF GO:0003724 0.0127122025202977 0.0130222562403049 660 736.363636363636 788 0.00116238698853215 441 0.812913487554374 -0.856725530839012 -1 1.42963187931555 441 868 788 809 894 745 659 500 834 905 657 871 M18520 GO_SUMO_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUMO_BINDING.html Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO. 15/17 Gene Ontology MF GO:0032183 0.0169104759610242 0.0172846015353832 905 718 789 0.00154926144573294 389 2.16630553334734 2.3789673732122 1 3.64585146940809 901 909 539 823 920 683 530 389 572 789 843 872 M18621 GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBON_NITROGEN_LIGASE_ACTIVITY_WITH_GLUTAMINE_AS_AMIDO_N_DONOR.html Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. 10/11 Gene Ontology MF GO:0016884 0.0253338851488633 0.0257519360589105 840 757.818181818182 791 0.00233003696157209 455 0.996953608132589 -1.38224364663992 -1 1.47982217639716 836 704 579 753 900 787 911 800 455 791 820 873 M19027 GO_SEQUENCE_SPECIFIC_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUENCE_SPECIFIC_DNA_BINDING.html Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. 749/1167 Gene Ontology MF GO:0043565 1.20429230797626e-06 2.815452174354e-06 740 747.818181818182 791 1.20429296062074e-07 397 1.68406391649074 1.79724529086988 1 9.0085529397472 740 836 907 791 397 847 711 824 617 690 866 874 M18760 GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING.html Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. 624/779 Gene Ontology MF GO:0000988 1.62162938190172e-06 3.4131789268273e-06 840 742.818181818182 792 1.62163056525977e-07 433 1.53720310215471 -1.49743470972726 -1 8.09335600208242 681 838 881 839 433 792 630 865 589 848 775 875 M19007 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_ACTIVITY_ROTATIONAL_MECHANISM.html Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism. 9/10 Gene Ontology MF GO:0046933 0.0211743245850962 0.0215474404368159 535 757.636363636364 792 0.00213788308906754 531 0.540436421658349 0.512852854233494 1 0.816795314993152 573 831 904 727 899 535 531 708 913 921 792 876 M19033 GO_MISFOLDED_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_PROTEIN_BINDING.html Interacting selectively and non-covalently with a misfolded protein. 18/19 Gene Ontology MF GO:0051787 0.203397141272132 0.205397768891202 855 757.909090909091 795 0.0204604240173473 498 2.29163765267839 -3.07348639357584 -1 1.47102847627251 851 906 588 505 919 860 746 895 795 774 498 877 M17928 GO_RNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. 45/48 Gene Ontology MF GO:0008173 2.7184701284167e-05 3.40361300631033e-05 770 807.818181818182 796 2.4713670184271e-06 728 0.938924759338595 0.925553217233928 1 4.01186760985481 884 796 763 805 728 794 768 844 903 835 766 878 M19214 GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_4_PHOSPHATE_BINDING.html Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. 24/25 Gene Ontology MF GO:0070273 7.11557551812152e-05 8.25978866676418e-05 800 695.454545454545 796 6.46891424667126e-06 185 1.85751006481781 2.68079986493206 1 7.29870583070197 803 891 523 506 787 800 810 885 185 796 664 879 M18435 GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_TRANSFERASE_ACTIVITY.html Catalysis of the transfer of a functional group from one position to another within a single molecule. 26/27 Gene Ontology MF GO:0016866 1.59601527196299e-07 1.65381926038186e-06 890 729.545454545455 798 1.45092307977069e-08 36 0.877254676932803 -0.713443130039878 -1 4.86210129439007 733 888 716 897 36 715 675 798 863 816 888 880 M18995 GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_ACTIVITY_TRANSFERRING_ONE_CARBON_GROUPS.html Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). 193/227 Gene Ontology MF GO:0016741 1.92153553497538e-05 2.51487087013774e-05 695 775.909090909091 799 1.74686574396093e-06 638 0.965956445757071 0.94117966910326 1 4.25212225612696 698 923 799 882 695 638 808 695 808 908 681 881 M19112 GO_TRNA_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. 20/20 Gene Ontology MF GO:0008175 0.00146288101599746 0.00154127942848536 800 743.272727272727 800 0.000133077696296724 335 0.980667892397408 -0.780458066336798 -1 2.6178220096408 653 818 713 800 870 627 335 854 883 800 823 882 M18223 GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISULFIDE_OXIDOREDUCTASE_ACTIVITY.html Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. 25/32 Gene Ontology MF GO:0015036 9.80542254400641e-06 1.3935816435452e-05 845 785.909090909091 804 8.91406022467987e-07 631 0.84900071024831 -0.870454026577891 -1 3.94151933651413 762 631 709 760 643 843 908 908 832 804 845 883 M18017 GO_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a substrate. 29/35 Gene Ontology MF GO:0032451 1.18886072220969e-05 1.63956314525635e-05 840 777.727272727273 805 1.08078831523406e-06 619 0.762395761236504 0.938974103002475 1 3.48146852301494 880 805 739 874 658 761 662 619 882 837 838 884 M18682 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_OXYGEN_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. 7/13 Gene Ontology MF GO:0050664 0.460623393432553 0.464139602542726 750 762.909090909091 805 0.0598671875495529 286 1.79175468626986 -1.45776193903383 -1 0.522540474619581 748 709 873 624 913 919 788 805 844 286 883 885 M19024 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. 46/65 Gene Ontology MF GO:0016860 1.01053853726926e-06 2.51004733450752e-06 630 749.636363636364 806 9.18671819496351e-08 355 1.10075163878472 -1.13605621806407 -1 5.92183156550583 629 874 742 842 355 889 906 600 806 838 765 886 M18797 GO_TRANSCRIPTION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_BINDING.html Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. 547/803 Gene Ontology MF GO:0008134 1.13386347626361e-06 2.70023157749376e-06 810 761.272727272727 808 1.1338640548049e-07 388 1.52975398973373 -1.39094094785212 -1 8.2048294675469 860 839 883 808 388 903 685 731 649 822 806 887 M19228 GO_HISTONE_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. 52/59 Gene Ontology MF GO:0042054 2.0869121686637e-05 2.68940982405196e-05 905 780.545454545455 808 1.8972108775465e-06 425 0.756699721544051 0.740038268217093 1 3.29730459409291 758 869 781 878 707 671 425 808 901 885 903 888 M18612 GO_TRANSLATION_INITIATION_FACTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_BINDING.html Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. 25/32 Gene Ontology MF GO:0031369 0.000109405748490279 0.000123583021522027 895 743.909090909091 809 9.94647178222436e-06 287 0.754691183529819 -0.613350613006414 -1 2.80365025951904 628 811 746 848 809 581 287 891 895 886 801 889 M18327 GO_HISTONE_DEMETHYLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEMETHYLASE_ACTIVITY.html Catalysis of the removal of a methyl group from a histone. 23/27 Gene Ontology MF GO:0032452 3.23261197070132e-05 3.97727491468444e-05 775 779.454545454545 812 2.93878133698104e-06 588 0.732764887838558 0.91847450790505 1 3.0704542982127 771 812 729 843 743 654 588 838 900 825 871 890 M18150 GO_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of an acetyl group to an acceptor molecule. 96/114 Gene Ontology MF GO:0016407 5.15528843512717e-05 6.09141497961317e-05 860 821.545454545455 813 4.68673567602791e-06 737 1.00869086472893 0.865316644671435 1 4.06689969612825 892 786 784 858 770 902 856 751 737 888 813 891 M18522 GO_MANNOSYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 20/22 Gene Ontology MF GO:0000030 3.6609231010234e-05 4.46855078645392e-05 825 781.909090909091 813 3.32816729295595e-06 646 0.876083566385631 1.05764082360441 1 3.63911041745144 821 813 692 824 749 899 844 646 723 840 750 892 M17930 GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_GATED_ION_CHANNEL_ACTIVITY.html Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. 3/12 Gene Ontology MF GO:0043855 0.0743423084089965 0.0753204966775359 845 687.818181818182 814 0.00769531589311531 261 2.32708267721128 -2.28693824500331 -1 2.47793565192114 843 474 805 330 904 888 814 883 261 456 908 893 M18871 GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium. 9/12 Gene Ontology MF GO:0010857 0.000276789706679475 0.000301241094195329 860 686.090909090909 814 2.76824188368049e-05 86 2.26149865100475 2.40394545063545 1 7.66593979215941 857 765 891 290 842 814 861 823 86 509 809 894 M18668 GO_RRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_BINDING.html Interacting selectively and non-covalently with ribosomal RNA. 66/89 Gene Ontology MF GO:0019843 6.37754857784158e-06 9.61526541431316e-06 880 786.090909090909 815 5.79778824154645e-07 601 1.17591059510903 -1.11155956005681 -1 5.66485633182759 610 864 714 908 601 876 798 815 748 876 837 895 M19081 GO_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY.html Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 566/838 Gene Ontology MF GO:0016491 3.94705869870624e-07 1.70429971387201e-06 925 753.727272727273 815 3.94705939977367e-08 204 1.64000685757487 -1.69078627081808 -1 9.11813217013602 921 651 912 884 204 755 815 910 578 740 921 896 M18323 GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY.html Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. 18/19 Gene Ontology MF GO:0010485 0.000119805772259511 0.000134508546254907 870 814.909090909091 816 1.08920270036525e-05 685 0.603029475405134 -0.601080331787433 -1 2.2073172461551 867 899 722 685 816 780 736 770 881 913 895 897 M18801 GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_SPECIFIC_PROTEASE_BINDING.html Interacting selectively and non-covalently with a ubiquitin-specific protease. 13/13 Gene Ontology MF GO:1990381 0.0135043828288288 0.0138184382434527 830 725.727272727273 816 0.00123527245265178 346 0.745455282549057 -0.745455282549057 -1 1.28765675476071 643 827 707 346 896 898 495 816 861 827 667 898 M18731 GO_GUANYL_NUCLEOTIDE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANYL_NUCLEOTIDE_BINDING.html Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. 337/417 Gene Ontology MF GO:0019001 5.27341831455631e-07 1.87024687461194e-06 920 767.818181818182 818 4.79401779872681e-08 239 1.43999581344467 1.54549216226393 1 7.94283572341846 818 920 758 889 239 776 883 809 607 830 917 899 M18419 GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_THREONINE_TYPE_PEPTIDASE_ACTIVITY.html Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. 18/23 Gene Ontology MF GO:0070003 0.276469071399014 0.2788836484418 820 706.272727272727 819 0.0289907372902874 272 0.657592094471416 0.485859102052193 1 0.296960321533343 418 819 725 834 911 437 272 819 865 862 807 900 M18335 GO_O_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. 18/20 Gene Ontology MF GO:0008171 0.0191777177422175 0.0195371677991279 900 799.272727272727 823 0.00175881470635528 482 1.00993610235976 0.911620508535896 1 1.61731617134776 814 900 700 871 898 823 857 482 857 773 817 901 M18036 GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_UBIQUITIN_LIGASE_ACTIVITY.html Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. 15/15 Gene Ontology MF GO:0034450 0.68618940391 0.68618940391 845 816.909090909091 824 0.1 686 0.719452589011684 -0.739261513622347 -1 0.0573989894407135 800 824 712 799 917 803 842 686 918 844 841 902 M19098 GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS.html Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. 44/44 Gene Ontology MF GO:0016875 0.000506868715540714 0.000545223158509453 855 778.272727272727 824 4.60895939249533e-05 577 0.715480003922792 -0.898062294202337 -1 2.20774193997841 599 738 775 853 851 859 824 724 871 890 577 903 M18210 GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHASE_ACTIVITY.html Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 13/13 Gene Ontology MF GO:0009982 7.57396146097975e-06 1.11098157588127e-05 625 787.727272727273 826 6.88544321459675e-07 621 0.765151707669256 -0.628537639801211 -1 3.6196832284502 776 908 666 869 622 848 761 621 889 826 879 904 M18596 GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_FACTOR_ACTIVITY_RNA_BINDING.html Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome. 93/115 Gene Ontology MF GO:0008135 1.55830497714634e-05 2.08980232058522e-05 785 810.363636363636 826 1.41665092277139e-06 680 1.0182553412501 1.22065642878612 1 4.56481986919735 826 858 792 861 680 851 887 688 782 904 785 905 M17899 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_A_HEME_GROUP_OF_DONORS.html Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 22/30 Gene Ontology MF GO:0016675 0.538239572313721 0.541757478015118 535 742.909090909091 836 0.0678357815314153 370 0.941046354091341 -0.676607339213767 -1 0.186222137851427 533 897 720 836 921 583 370 845 870 850 747 906 M18478 GO_DOUBLE_STRANDED_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRANDED_DNA_BINDING.html Interacting selectively and non-covalently with double-stranded DNA. 641/898 Gene Ontology MF GO:0003690 1.24514090139756e-06 2.85486400221178e-06 895 760.636363636364 837 1.24514159906725e-07 403 1.7288129875534 1.82118821907901 1 9.23931369626029 891 837 862 726 403 885 796 871 613 603 880 907 M18246 GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY.html Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. 12/14 Gene Ontology MF GO:0004861 0.0002359712236852 0.000258338164318869 840 823.454545454545 840 2.14542306978822e-05 613 0.999104360165728 1.28145721411158 1 3.41971682717229 840 910 613 828 838 867 792 862 885 746 877 908 M17958 GO_SIGNAL_SEQUENCE_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_SEQUENCE_BINDING.html Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. 39/50 Gene Ontology MF GO:0005048 0.000640770538421211 0.00068447627456786 865 797.818181818182 845 5.82688404508183e-05 632 1.37681348910042 1.7498418172344 1 4.16893027775084 796 881 698 845 859 864 897 714 632 864 726 909 M19066 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H_QUINONE_OR_SIMILAR_COMPOUND_AS_ACCEPTOR.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. 52/67 Gene Ontology MF GO:0016655 0.0839147814420694 0.0849258029052268 370 720.090909090909 845 0.00793614891175047 289 1.12430964479515 -1.55576350712443 -1 1.11103811386546 367 872 747 849 905 499 289 799 845 894 855 910 M17996 GO_RNA_POLYMERASE_III_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_III_ACTIVITY.html Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 19/21 Gene Ontology MF GO:0001056 3.83125329597287e-05 4.64577171322694e-05 860 829.363636363636 850 3.48301819823855e-06 711 0.753974066278823 -0.583107146226808 -1 3.11163006952079 856 903 711 840 754 879 791 781 891 867 850 911 M18003 GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H.html Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 81/105 Gene Ontology MF GO:0016651 0.0721034809802878 0.0731324000283051 905 778.272727272727 850 0.00678009817288539 451 1.147196945475 -1.32417448249518 -1 1.20704967393047 633 860 764 850 903 606 451 877 831 884 902 912 M19070 GO_RIBOSOME_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BINDING.html Interacting selectively and non-covalently with any part of a ribosome. 53/56 Gene Ontology MF GO:0043022 2.51724027534676e-05 3.17462386542904e-05 870 833 852 2.28842643461321e-06 721 1.20427859869306 1.22920608938432 1 5.19703796546199 858 870 741 852 721 850 837 876 819 866 873 913 M18587 GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BINDING.html Interacting selectively and non-covalently with any complex of RNA and protein. 114/123 Gene Ontology MF GO:0043021 8.90395889228013e-05 0.00010169663802802 855 830.090909090909 855 8.09483570776046e-06 682 1.12773537431127 -1.14157122851275 -1 4.31011795157983 855 851 782 860 801 870 904 682 742 903 881 914 M18119 GO_N_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. 79/90 Gene Ontology MF GO:0008170 1.2772681990994e-05 1.74843824587829e-05 785 823.090909090909 857 1.16115964970736e-06 665 0.813694439954464 0.787435487340379 1 3.6975051525907 781 861 789 879 665 857 693 919 874 887 849 915 M18148 GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY.html Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. 12/17 Gene Ontology MF GO:0017110 0.00228162178422952 0.00238756345257993 880 807 861 0.000207635590675543 515 1.04224674947435 0.852632051646121 1 2.59363795195392 861 826 603 891 876 915 797 794 880 515 919 916 M19174 GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_INTERCONVERTING_ALDOSES_AND_KETOSES.html Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. 11/12 Gene Ontology MF GO:0016861 0.577473372149294 0.579984125941248 925 812.272727272727 861 0.0753300696864791 641 0.509448855894011 -0.47899574294291 -1 0.0601694066262662 804 915 705 646 923 861 721 641 922 922 875 917 M18389 GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group (CH3-) to a protein. 74/84 Gene Ontology MF GO:0008276 0.000232285871951117 0.000254605155021153 900 824 863 2.11191273965249e-05 627 0.773058530768164 0.771299726469244 1 2.63791738546283 870 863 791 881 837 908 627 768 898 899 722 918 M18385 GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DIRECTED_DNA_POLYMERASE_ACTIVITY.html Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. 8/8 Gene Ontology MF GO:0003964 0.6513215599 0.653443128499023 920 857.181818181818 865 0.1 750 0.731163749535048 0.731163749535048 1 0.0743152642402673 750 916 852 798 918 865 865 829 923 914 799 919 M18639 GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_TRISPHOSPHATE_KINASE_ACTIVITY.html Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. 9/11 Gene Ontology MF GO:0051766 0.00232743897138976 0.00243275295199563 870 777 869 0.000232988020812495 483 0.67902276696031 -0.583218769218294 -1 1.66462275065307 784 646 872 641 877 900 483 870 869 919 686 920 M18785 GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_DEPENDENT_METHYLTRANSFERASE_ACTIVITY.html Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. 126/147 Gene Ontology MF GO:0008757 2.48254511181812e-05 3.14228997715061e-05 815 850.363636363636 871 2.25688466003134e-06 719 0.949320709535857 0.843886909231611 1 4.08885765183212 914 849 796 880 719 871 811 896 814 900 904 921 M18105 GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_INITIATION_FACTOR_ACTIVITY.html Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. 55/75 Gene Ontology MF GO:0003743 0.063248473615769 0.0642215270560116 905 840.727272727273 876 0.0059221411130464 656 0.621171740929477 -0.610052305800119 -1 0.66156627643901 656 876 794 916 902 804 744 903 914 909 830 922 M19092 GO_PRE_MRNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MRNA_BINDING.html Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. 36/40 Gene Ontology MF GO:0036002 0.00577299602385507 0.00598009902022655 890 818.272727272727 883 0.000526200069750237 636 0.845228951392412 0.722312059672488 1 1.76576739430748 636 886 768 912 886 686 705 888 912 883 839 923 M18431 GO_OXYGEN_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORTER_ACTIVITY.html Enables the directed movement of oxygen into, out of or within a cell, or between cells. 4/17 Gene Ontology MF GO:0005344 0.683406115018391 0.684888557784157 920 853.727272727273 892 0.108645929242471 587 0.355797218594638 -0.310159388935834 -1 0 816 917 857 765 915 892 587 913 924 916 889 924 M19216 GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. 11/14 Gene Ontology MF GO:0097153 0.68618940391 0.68618940391 920 823.818181818182 903 0.1 469 0.634532184404073 -0.572295153389873 -1 0.0439288357677199 834 913 674 903 916 825 469 765 921 924 918