Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M17385 GO_CILIARY_TRANSITION_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TRANSITION_ZONE.html A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition. 25/25 Gene Ontology CC GO:0035869 0.000160570117744153 0.00138142497608269 10 107.818181818182 19 1.45983489435812e-05 2 0.930748550568653 -0.95994200113521 -1 4.37169141602988 28 36 215 13 579 7 2 19 5 276 6 2 M17401 GO_TCTN_B9D_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TCTN_B9D_COMPLEX.html A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins. 12/12 Gene Ontology CC GO:0036038 0.000315483534141863 0.00224739414141592 10 58.6363636363636 23 2.86844349156545e-05 8 0.987303127643907 -0.987303127643907 -1 4.29377086630703 50 57 220 23 10 16 24 8 17 210 10 3 M17236 GO_NUCLEAR_NUCLEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_NUCLEOSOME.html A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. 16/61 Gene Ontology CC GO:0000788 0.000153084644921234 0.00135760570509638 40 44.8181818181818 29 1.39177543809277e-05 1 1.78702545595645 -1.78702545595645 -1 8.45882769057352 11 125 44 157 24 8 1 39 18 29 37 4 M17067 GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 274/347 Gene Ontology CC GO:0031300 0.0026903155901961 0.0109386754534821 35 123.272727272727 36 0.000244873740163212 10 0.939193570802283 -0.874475720895512 -1 3.01077162590671 36 81 342 81 35 10 35 36 309 360 31 5 M17616 GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT.html A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. 14/15 Gene Ontology CC GO:0044322 0.00117557002667295 0.00593918422171288 35 73.6363636363636 36 0.000106927151168881 9 0.733967711604779 -0.7955986658808 -1 2.66586398086132 33 50 242 18 14 69 88 24 9 227 36 6 M17671 GO_KERATIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATIN_FILAMENT.html A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. 27/107 Gene Ontology CC GO:0045095 2.6635739969033e-05 0.00032240343587517 15 161.272727272727 36 2.42146022341082e-06 11 2.58162706078538 -2.58162706078538 -1 14.9164606018949 14 340 33 354 381 11 11 130 434 36 30 7 M16996 GO_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_COMPLEX.html A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. 77/87 Gene Ontology CC GO:0000502 0.000162241790554365 0.00138142497608269 65 115.818181818182 42 1.47503415014949e-05 7 0.618177812469783 -0.626033399325014 -1 2.88792449120705 7 13 481 29 42 18 37 58 64 460 65 8 M17784 GO_CILIARY_BASAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASAL_BODY.html A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. 84/106 Gene Ontology CC GO:0036064 0.000592677323079307 0.00353606033773571 15 87.9090909090909 45 5.38942772613198e-05 5 1.03341036207345 -1.01504265984594 -1 4.1587981475915 29 188 268 90 93 5 12 14 45 209 14 9 M17404 GO_PROTEASOME_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_CORE_COMPLEX.html A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. 18/22 Gene Ontology CC GO:0005839 0.000137082448797077 0.00124445160548597 10 84.1818181818182 46 1.2462817379784e-05 3 0.697106975645691 -0.697106975645691 -1 3.31507685902421 6 40 273 57 82 15 19 46 3 315 70 10 M17690 GO_CORNIFIED_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORNIFIED_ENVELOPE.html A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). 16/67 Gene Ontology CC GO:0001533 0.000349363399297108 0.00236239689673179 50 79.2727272727273 46 3.17653537347433e-05 6 1.77726236036458 -1.97210349685257 -1 7.70260143808488 23 47 48 84 16 13 6 346 225 46 18 11 M17506 GO_DNA_PACKAGING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING_COMPLEX.html A protein complex that plays a role in the process of DNA packaging. 41/109 Gene Ontology CC GO:0044815 0.000327288096488556 0.00226374266737918 15 79.5454545454545 49 2.9757890582151e-05 4 1.68879121243806 -1.80679110578603 -1 7.3687870524367 12 253 56 257 79 4 7 41 100 49 17 12 M17144 GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE.html The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 142/180 Gene Ontology CC GO:0031227 0.00192122698898011 0.0085864067738265 10 153.727272727273 54 0.000174809711072959 9 0.894511972079699 -0.765195259404409 -1 3.02145965384365 44 182 382 166 54 9 22 38 380 405 9 13 M17691 GO_PERIKARYON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIKARYON.html The portion of the cell soma (cell body) that excludes the nucleus. 120/202 Gene Ontology CC GO:0043204 3.6215675101962e-06 6.01180206692569e-05 45 78.7272727272727 55 3.29233951992277e-07 1 1.4188064957446 1.39981244126864 1 9.89465312422007 75 1 26 55 276 43 58 196 69 25 42 14 M17493 GO_HEMOGLOBIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_COMPLEX.html An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. 3/15 Gene Ontology CC GO:0005833 0.000734796977574878 0.0041448256696214 55 152.181818181818 60 7.35040057674245e-05 5 1.79733728753816 -1.79733728753816 -1 7.06169203365612 51 60 548 244 17 24 5 455 106 130 34 15 M17047 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE.html The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 21/28 Gene Ontology CC GO:0031306 0.00233023627047874 0.00981063241411703 35 130.636363636364 61 0.000212064374455679 19 0.737919056327513 -0.780501550506281 -1 2.41346906687183 53 209 320 200 128 32 61 33 19 336 46 16 M17550 GO_INTRACILIARY_TRANSPORT_PARTICLE_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE_B.html The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. 22/24 Gene Ontology CC GO:0030992 0.000283487028900863 0.00205882454739251 5 161.090909090909 64 2.57748695445594e-05 2 0.770216752317578 -0.770216752317578 -1 3.38808960723832 31 261 327 231 447 2 4 64 59 344 2 17 M17217 GO_INTERMEDIATE_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT.html A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. 81/224 Gene Ontology CC GO:0005882 0.000172866372377722 0.00141458256833037 40 174 68 1.57163597231976e-05 12 1.75610970572295 -2.02894620817544 -1 8.25963561554929 38 293 43 357 298 12 29 301 451 68 24 18 M17189 GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. 19/32 Gene Ontology CC GO:0032281 5.87733857981187e-05 0.000649465667272028 50 126.181818181818 76 5.34317781801407e-06 4 1.29043402797349 -1.29043402797349 -1 6.78122485254714 48 264 76 169 142 21 8 4 440 173 43 19 M17574 GO_CILIARY_BASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASE.html Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. 22/25 Gene Ontology CC GO:0097546 0.000996696658639953 0.00519119411463313 60 76.9090909090909 76 9.06498629658011e-05 21 1.12743986788322 -1.13682793192148 -1 4.22936956166185 60 120 153 91 102 46 52 21 76 85 40 20 M17601 GO_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL.html Extracellular matrix material consisting of polysaccharides and protein. 16/23 Gene Ontology CC GO:0043205 2.39391585680372e-05 0.000302361981044123 25 196.818181818182 77 2.17631082403824e-06 2 1.52419396968999 1.52419396968999 1 8.85813882026434 25 500 77 468 320 35 13 2 559 146 20 21 M17838 GO_CHYLOMICRON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHYLOMICRON.html A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. 5/15 Gene Ontology CC GO:0042627 8.46724014685905e-06 0.000126140167316028 5 177 77 8.46727240940214e-07 1 1.04571304964996 1.21495237418373 1 6.72180202481741 61 225 580 246 570 71 3 1 77 100 13 22 M17816 GO_CLATHRIN_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_ADAPTOR_COMPLEX.html A membrane coat adaptor complex that links clathrin to a membrane. 31/34 Gene Ontology CC GO:0030131 0.00278767799278319 0.0110179654000479 80 111.454545454545 78 0.000253746964734012 15 0.856974421464131 -0.843036686249354 -1 2.73866436970523 159 33 286 78 85 76 103 37 15 305 49 23 M17201 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX.html A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. 32/56 Gene Ontology CC GO:0008328 0.000392132759662042 0.00258896742458689 80 130.545454545455 79 3.56547883363546e-05 11 1.3912438313747 -1.23748443784823 -1 5.92764302821771 79 256 59 168 232 28 38 11 361 163 41 24 M17017 GO_PHOSPHATASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_COMPLEX.html A protein complex which is capable of phosphatase activity. 49/58 Gene Ontology CC GO:1903293 0.00450398103090581 0.0159561767009529 75 171.181818181818 80 0.00041029348954222 16 0.760888628474706 0.880781079637635 1 2.22324604920073 35 200 410 211 389 41 16 80 74 354 73 25 M17295 GO_CILIARY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PART.html Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 291/415 Gene Ontology CC GO:0044441 0.00087338311019574 0.00487918833676659 135 108.363636363636 80 7.94300026740594e-05 6 1.11717961728664 -1.11816035791009 -1 4.24037882628385 58 80 135 9 472 6 72 87 117 134 22 26 M17780 GO_PROTEASOME_ACCESSORY_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ACCESSORY_COMPLEX.html A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. 25/28 Gene Ontology CC GO:0022624 0.0114456684033338 0.0267750521949144 40 151.636363636364 82 0.00104596842990589 27 0.525246712701649 -0.525246712701649 -1 1.32430169299776 27 38 437 106 164 39 46 69 84 576 82 27 M17016 GO_FILOPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a filopodium. 19/22 Gene Ontology CC GO:0031527 0.0133045535159143 0.0301950999716648 35 92.1818181818182 83 0.00121688190924985 31 1.63194527955379 1.69934073286366 1 4.07127660088024 68 45 83 135 179 111 31 146 33 136 47 28 M17230 GO_CILIARY_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TIP.html Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. 55/63 Gene Ontology CC GO:0097542 0.000235368855343568 0.00177729059039401 10 102.818181818182 84 2.13994582046666e-05 1 0.877947616500811 -0.878715811481463 -1 3.96156486754658 18 109 257 221 84 1 10 6 122 291 12 29 M17447 GO_LAMELLIPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a lamellipodium. 32/37 Gene Ontology CC GO:0031258 6.66259433148529e-05 0.000684128992137128 5 112.818181818182 84 6.05708737591797e-06 3 1.60249363482643 1.62945252219212 1 8.37228457997205 84 34 68 146 527 103 118 5 56 97 3 30 M17585 GO_GOLGI_TRANSPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TRANSPORT_COMPLEX.html A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). 12/12 Gene Ontology CC GO:0017119 0.000897488910183834 0.00492030376015304 85 211.636363636364 85 8.16232045076727e-05 12 0.492963828726214 -0.492963828726214 -1 1.84210542883354 85 356 378 322 12 25 28 71 452 561 38 31 M17604 GO_AXOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXOLEMMA.html The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. 22/34 Gene Ontology CC GO:0030673 0.00577426225782821 0.0159754589133247 40 131.090909090909 86 0.000526315789473684 39 1.42805927268243 -1.51860009996099 -1 4.21223257128361 177 39 85 39 196 271 339 55 63 86 92 32 M17802 GO_MICROBODY_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_LUMEN.html The volume enclosed by the membranes of a microbody. 43/53 Gene Ontology CC GO:0031907 0.00115066121801269 0.00586433480408223 30 94.8181818181818 88 0.000104660316990849 23 1.13466116956616 -1.09844314413321 -1 4.15702253580859 99 26 219 52 28 126 148 23 34 200 88 33 M17224 GO_AXON_INITIAL_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_INITIAL_SEGMENT.html Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. 17/26 Gene Ontology CC GO:0043194 2.5251480377307e-05 0.00031215127870671 100 100.363636363636 96 2.2956154742803e-06 3 1.28615465513783 1.56758370791167 1 7.43791463844379 74 126 96 208 61 97 48 3 131 205 55 34 M17084 GO_NEURON_PROJECTION_TERMINUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_TERMINUS.html The specialized, terminal region of a neuron projection such as an axon or a dendrite. 136/226 Gene Ontology CC GO:0044306 6.71176463886684e-05 0.000684128992137128 100 139.636363636364 97 6.10179037297277e-06 37 1.3392164986705 1.27098265063654 1 6.98913559475989 114 97 37 97 166 87 127 444 247 51 69 35 M17075 GO_ACROSOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_MEMBRANE.html The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. 15/29 Gene Ontology CC GO:0002080 0.00175059363782218 0.00807218177440226 95 126.272727272727 98 0.000159271652877247 29 1.17011700854404 -1.05227273418404 -1 4.01882976689138 94 134 176 268 70 84 98 29 143 235 58 36 M17174 GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE.html The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 14/16 Gene Ontology CC GO:0031231 0.00995650576308346 0.0239038423485599 200 193.727272727273 98 0.000909259395282921 54 0.757826299122077 -0.757826299122077 -1 1.99328798547101 93 54 262 198 98 65 69 66 514 512 200 37 M17617 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE.html The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 49/59 Gene Ontology CC GO:0098573 0.011475022369249 0.0267750521949144 45 187.090909090909 98 0.00104866508201747 41 0.689201197913865 -0.709217758593346 -1 1.75221065118667 41 198 447 245 323 44 70 70 85 437 98 38 M17262 GO_CELL_CORTEX_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_REGION.html The complete extent of cell cortex that underlies some some region of the plasma membrane 16/25 Gene Ontology CC GO:0099738 0.000565659185333368 0.0034594524913546 80 124.454545454545 101 5.14367889782173e-05 13 1.15755493531007 1.18487314771114 1 4.68226896608456 72 131 236 152 274 101 80 13 36 198 76 39 M17525 GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN.html The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. 23/28 Gene Ontology CC GO:0035327 0.00813747962462995 0.0205477894327546 55 162 101 0.000742521433769009 51 1.31716409452237 -1.41344984135857 -1 3.64251339772421 73 257 172 394 65 79 54 101 366 170 51 40 M17733 GO_GOLGI_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LUMEN.html The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. 58/156 Gene Ontology CC GO:0005796 3.7413548905969e-12 1.67209783956677e-10 10 204.727272727273 101 3.40123171873023e-13 8 1.79879720478592 1.80080657454988 1 29.1463466155434 101 19 8 46 515 554 336 373 98 8 194 41 M17355 GO_CORTICAL_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_ACTIN_CYTOSKELETON.html The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. 82/106 Gene Ontology CC GO:0030864 0.00577426225782821 0.0159754589133247 80 107.636363636364 102 0.000526315789473684 28 1.06907531678954 -1.1217024653381 -1 3.1416637812924 150 102 154 28 80 59 129 140 188 77 77 42 M17606 GO_APICAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the apical end of the cell. 326/492 Gene Ontology CC GO:0016324 1.24220626253507e-11 4.51076149083047e-10 15 150.272727272727 102 1.1292784204928e-12 11 1.32947473429165 1.34931119008155 1 20.5785104373071 76 168 11 82 495 106 74 102 308 13 218 43 M17286 GO_ORGANELLAR_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_RIBOSOME.html A ribosome contained within a subcellular membrane-bounded organelle. 71/80 Gene Ontology CC GO:0000313 0.00207706469761117 0.00887334256847125 105 193.181818181818 106 0.000189002572045498 17 0.652400303725191 -0.634091097314796 -1 2.17560065586741 17 106 484 103 186 105 73 216 102 470 263 44 M17754 GO_PROTEIN_LIPID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX.html A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. 33/64 Gene Ontology CC GO:0032994 0.00196858793114253 0.00859962096235949 30 134.818181818182 106 0.00017912287804547 21 1.34142462519146 1.51342118934064 1 4.55280128351844 285 30 65 21 32 432 187 30 176 106 119 45 M17716 GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE.html A clathrin coat found on an endocytic vesicle. 15/17 Gene Ontology CC GO:0030128 6.28891212961958e-05 0.000664337808601632 5 104.545454545455 107 5.71735628311973e-06 2 0.920482278826675 -0.830678824588079 -1 4.80875970777103 136 48 230 40 2 175 107 107 4 237 64 46 M17495 GO_RESPIRATORY_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN.html The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. 76/93 Gene Ontology CC GO:0070469 9.67898630810766e-08 2.2499403457984e-06 25 156.909090909091 108 8.79907884903499e-09 1 0.60038037387943 -0.60038037387943 -1 5.58215948389402 1 190 449 160 108 23 25 84 96 472 118 47 M17578 GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). 33/36 Gene Ontology CC GO:0000315 0.00861911052686737 0.021040769815588 35 175.727272727273 109 0.00078664224232019 24 0.575330527049869 -0.575330527049869 -1 1.55497878844891 24 31 442 109 197 56 34 152 108 560 220 48 M17760 GO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM.html A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. 473/685 Gene Ontology CC GO:0005929 0.00577426225782821 0.0159754589133247 85 168.727272727273 110 0.000526315789473684 8 1.11388024308955 -1.10184253944313 -1 3.2752818857989 242 73 110 8 504 20 317 274 141 84 83 49 M17453 GO_PRESYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_MEMBRANE.html A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. 53/95 Gene Ontology CC GO:0042734 0.000897680204089883 0.00492030376015304 365 197.181818181818 111 8.16406090652224e-05 17 1.39208856366182 -1.71204204198793 -1 5.28686019584913 364 196 111 101 90 515 486 17 107 116 66 50 M17142 GO_APICAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PART_OF_CELL.html The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. 410/594 Gene Ontology CC GO:0045177 1.96772437463013e-12 1.03931623787282e-10 60 148.272727272727 112 1.78884034057444e-13 7 1.33137525459731 1.35049114225129 1 22.0169042758586 59 164 7 156 512 89 71 112 258 16 187 51 M17543 GO_NADH_DEHYDROGENASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX.html An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. 45/51 Gene Ontology CC GO:0030964 9.92166668581465e-07 1.98775460153735e-05 5 147.909090909091 112 9.01970105485349e-08 4 0.586476300608768 -0.586476300608768 -1 4.53065474148054 4 194 348 163 118 22 14 94 110 448 112 52 M17707 GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX.html Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). 42/45 Gene Ontology CC GO:0030119 0.00653856685945675 0.0173660967836959 65 134.090909090909 112 0.000596189201995058 23 0.846163833457077 -0.82821457776025 -1 2.42597740915992 123 112 352 153 83 26 63 119 62 359 23 53 M17685 GO_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_CILIUM.html A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors. 233/307 Gene Ontology CC GO:0072372 0.00577426225782821 0.0159754589133247 90 167.909090909091 113 0.000526315789473684 10 1.09770621012129 -1.02431438518191 -1 3.22704737665199 225 86 105 10 480 17 301 240 181 113 89 54 M17048 GO_OXIDOREDUCTASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_COMPLEX.html Any protein complex that possesses oxidoreductase activity. 90/106 Gene Ontology CC GO:1990204 0.000221868325719469 0.00171873996324015 95 163.636363636364 114 2.01718821937196e-05 9 0.667265629226578 -0.636855884496834 -1 3.01584701217759 9 186 443 167 94 31 45 95 114 461 155 55 M17766 GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 34/45 Gene Ontology CC GO:0046658 8.39430997498979e-06 0.000126140167316028 115 121.818181818182 114 7.63122000404707e-07 22 1.78946509502363 1.87847613292926 1 11.5357209930653 149 114 29 121 345 215 112 53 48 22 132 56 M17127 GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinase (CDK) complex found in the nucleus. 16/20 Gene Ontology CC GO:0019908 0.0192922205454455 0.0407592004978322 40 170.818181818182 115 0.00176940947898693 6 0.901508208734572 0.901508208734572 1 2.03321559801099 37 350 306 295 205 74 42 85 6 364 115 57 M17674 GO_PRESYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPSE.html The part of a synapse that is part of the presynaptic cell. 272/414 Gene Ontology CC GO:0098793 0.00577426225782821 0.0159754589133247 540 206.636363636364 115 0.000526315789473684 29 1.19821597098755 -1.40182240268475 -1 3.52678949968159 539 83 99 31 86 478 527 115 159 127 29 58 M17185 GO_CLATHRIN_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT.html A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. 53/66 Gene Ontology CC GO:0030118 0.00194174948140418 0.00859962096235949 80 132 116 0.000176678674200153 20 0.890096452489343 -0.846451998459846 -1 3.00532845480497 233 21 261 77 20 78 140 116 148 310 48 59 M17343 GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX.html A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. 284/408 Gene Ontology CC GO:0005578 4.29434202145324e-35 8.31670904821445e-33 5 177.272727272727 116 3.90394729223023e-36 2 1.56821406756633 1.56522698018325 1 83.4640078222036 8 406 2 349 248 143 109 106 459 4 116 60 M17191 GO_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_COMPLEX.html A protein complex which is capable of protein kinase activity. 95/131 Gene Ontology CC GO:1902911 0.00577426225782821 0.0159754589133247 95 152.272727272727 117 0.000526315789473684 7 0.871115645070115 0.954051979028411 1 2.55130467821608 165 7 316 25 303 117 93 86 91 313 159 61 M17323 GO_MICROVILLUS_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_MEMBRANE.html The portion of the plasma membrane surrounding a microvillus. 25/30 Gene Ontology CC GO:0031528 0.000922510934016764 0.00496276715429389 120 153.454545454545 117 8.38998174046615e-05 26 1.82072519838459 1.78288624856151 1 6.91778687885119 117 118 52 138 575 115 26 131 75 67 274 62 M17092 GO_GLYCOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_COMPLEX.html A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. 17/23 Gene Ontology CC GO:0090665 0.00301177382586619 0.0117438965961628 115 131.363636363636 118 0.000274173166180254 11 1.1566597071121 1.15154301850175 1 3.65945377660532 112 220 207 108 250 122 83 118 55 159 11 63 M17365 GO_BANDED_COLLAGEN_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BANDED_COLLAGEN_FIBRIL.html A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). 22/23 Gene Ontology CC GO:0098643 0.000246742122690482 0.00183791247798936 10 187.090909090909 119 2.24336182295614e-05 10 1.4029720638672 1.4029720638672 1 6.32454949923214 10 307 54 297 257 99 106 161 555 119 93 64 M17821 GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX.html A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. 12/13 Gene Ontology CC GO:0036513 0.0071280465081593 0.0184883706305382 70 202.909090909091 119 0.0006501133486687 47 0.52319719458589 -0.52319719458589 -1 1.45863383804243 70 276 384 305 119 80 47 57 233 580 81 65 M17212 GO_CORTICAL_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON.html The portion of the cytoskeleton that lies just beneath the plasma membrane. 102/134 Gene Ontology CC GO:0030863 0.0256502519118336 0.0508406330444489 95 149.545454545455 121 0.00235948072229781 4 1.04204252711582 -1.11814280159919 -1 2.19139481699676 238 4 134 69 121 94 228 129 436 91 101 66 M17011 GO_INFLAMMASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMASOME_COMPLEX.html A cytosolic protein complex that is capable of activating caspase-1. 6/12 Gene Ontology CC GO:0061702 0.00555087551416044 0.0159754589133247 285 183.636363636364 122 0.000556478995463579 52 1.31661744683093 1.28693216816698 1 3.87988863585756 282 58 512 61 52 195 211 83 86 122 358 67 M17023 GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 18/21 Gene Ontology CC GO:0031362 0.000257747295545636 0.00189558454065841 125 241.545454545455 123 2.34343179655917e-05 32 1.84242532932187 -1.67325382527808 -1 8.27913310180306 573 123 46 124 115 497 526 111 32 41 469 68 M17172 GO_LIPID_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE.html An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. 70/94 Gene Ontology CC GO:0005811 0.00821446564572741 0.0205477894327546 340 138.909090909091 123 0.000749572591656094 14 1.09779529239778 -1.15467881010836 -1 3.02811305269929 337 14 145 53 321 85 149 197 78 123 26 69 M17530 GO_AXON_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_CYTOPLASM.html Any cytoplasm that is part of a axon. 34/40 Gene Ontology CC GO:1904115 0.00195616765171995 0.00859962096235949 85 158.454545454545 123 0.000177991743633234 8 1.0396463584444 -1.0066762010545 -1 3.5180915172492 82 377 325 181 123 83 23 77 144 320 8 70 M16983 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. 10/18 Gene Ontology CC GO:0034362 0.000681426000133901 0.00394353750110655 490 204.454545454545 127 6.19670141794477e-05 11 1.41888571140698 -1.13063039141254 -1 5.61588574409183 487 139 127 95 11 496 383 50 16 125 320 71 M17560 GO_INTRACILIARY_TRANSPORT_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE.html A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. 35/39 Gene Ontology CC GO:0030990 0.000520232557136114 0.00332148478786904 30 131.454545454545 129 4.73050560844955e-05 3 0.778479264851895 -0.744504283882608 -1 3.15651680046172 19 202 311 225 129 3 9 28 165 327 28 72 M17806 GO_GOLGI_CISTERNA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA_MEMBRANE.html The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. 72/86 Gene Ontology CC GO:0032580 0.00458866489536409 0.0159726173488158 130 198.272727272727 130 0.000418023979568978 15 1.17017927339557 -1.07110296330446 -1 3.4433279915684 376 15 181 125 39 128 267 530 130 112 278 73 M17746 GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. 15/34 Gene Ontology CC GO:0034361 0.000349683533767528 0.00236239689673179 130 151.181818181818 132 3.17944661189843e-05 9 1.14949663468566 1.32538246101151 1 4.96544025099017 129 132 139 195 87 400 250 9 52 140 130 74 M17741 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated endocytic vesicle. 42/55 Gene Ontology CC GO:0030669 0.00269230738355928 0.0109386754534821 25 271.727272727273 133 0.000245055256447758 25 1.14444273393802 -0.974916986267321 -1 3.67891218614127 550 25 108 72 25 578 543 407 82 133 466 75 M17840 GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE.html A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood. 15/34 Gene Ontology CC GO:0034385 0.000235544536076314 0.00177729059039401 135 151.909090909091 133 2.14154325997513e-05 7 1.14949663468566 1.32538246101151 1 5.20127490052939 130 133 140 196 88 401 251 7 53 141 131 76 M17177 GO_POSTSYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPSE.html The part of a synapse that is part of the post-synaptic cell. 372/552 Gene Ontology CC GO:0098794 6.02168280412994e-05 0.000649465667272028 105 185.545454545455 134 5.47440693785926e-06 35 1.13129997065674 1.07303444171104 1 5.93923528410126 102 166 35 128 368 104 134 398 342 81 183 77 M17280 GO_AXONAL_GROWTH_CONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_GROWTH_CONE.html The migrating motile tip of a growing nerve cell axon. 37/44 Gene Ontology CC GO:0044295 0.00143193044523288 0.00699118982084287 125 181.454545454545 134 0.000130260300606021 34 1.50216326743135 1.38256888162085 1 5.32816781486055 172 113 63 134 256 276 295 123 123 34 407 78 M17549 GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX.html A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. 17/20 Gene Ontology CC GO:0005942 0.0374686151149971 0.0706794330578355 135 178.545454545455 134 0.00346567207248835 75 0.909573032062423 -0.999350786436125 -1 1.6908611350262 134 130 266 174 364 227 122 117 95 260 75 79 M17409 GO_CHLORIDE_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_COMPLEX.html An ion channel complex through which chloride ions pass. 20/50 Gene Ontology CC GO:0034707 0.0492316348034365 0.0880110148332203 80 203.636363636364 136 0.00457901291807306 62 1.51966400154025 1.71826052268817 1 2.61595927088182 133 306 136 241 576 213 62 127 80 286 80 80 M17160 GO_MICROBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY.html Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 142/169 Gene Ontology CC GO:0042579 0.00591686247559288 0.016139422996805 245 163.818181818182 137 0.000539348723027892 50 1.05415740972336 -1.05852169658815 -1 3.08941522074373 188 93 244 50 244 133 248 52 115 298 137 81 M17666 GO_MHC_CLASS_II_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. 8/11 Gene Ontology CC GO:0042613 0.0181757839431692 0.0385406221568661 140 162.181818181818 137 0.00183261797157963 45 1.73013268205748 -1.54491009802153 -1 4.01465116214231 121 143 566 129 138 148 137 96 105 156 45 82 M17458 GO_MITOCHONDRIAL_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_PART.html Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. 170/199 Gene Ontology CC GO:0044455 1.81198618022856e-05 0.000233947549047288 490 184.272727272727 138 1.64727373133083e-06 5 0.643428149051306 -0.626417343643574 -1 3.83149492681719 5 240 490 164 113 33 39 99 220 486 138 83 M16974 GO_FILOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM.html Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. 140/172 Gene Ontology CC GO:0030175 0.0172238892439251 0.0370632579656314 140 246.272727272727 140 0.00157820295864469 74 1.19961019810512 -1.18611092410457 -1 2.80313912460218 377 94 74 136 100 433 370 515 140 89 381 84 M17249 GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX.html A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. 10/11 Gene Ontology CC GO:0000164 0.00618169495739798 0.0167049524197592 110 152.363636363636 140 0.000563557572803251 27 0.72596821298838 0.847314414357337 1 2.09507430188607 125 140 272 207 53 153 110 164 27 319 106 85 M17765 GO_TERMINAL_BOUTON http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINAL_BOUTON.html Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. 63/105 Gene Ontology CC GO:0043195 0.0328231362183548 0.0623210527544579 120 183.454545454545 140 0.00302939308134884 86 1.29553790549641 1.08827879756712 1 2.54565484506898 160 248 116 296 140 116 128 438 103 187 86 86 M17748 GO_MITOCHONDRIAL_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PROTEIN_COMPLEX.html A protein complex that is part of a mitochondrion. 133/156 Gene Ontology CC GO:0098798 1.04390387946421e-07 2.33272366911041e-06 5 189.818181818182 143 9.49003571816032e-09 3 0.573741618391671 -0.574195057526032 -1 5.31746938174381 3 242 493 223 143 29 32 92 204 488 139 87 M17087 GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX.html The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. 13/15 Gene Ontology CC GO:0008540 0.0273221297882087 0.053268984587078 45 181.818181818182 144 0.00251522425964164 44 0.4622634590815 -0.4622634590815 -1 0.930680354593708 45 135 364 178 144 47 44 109 273 507 154 88 M17229 GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM.html The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. 14/22 Gene Ontology CC GO:0097038 0.00973612325207837 0.0234717328193259 145 231.090909090909 144 0.000889043584539274 29 1.12256988503839 -1.27802472519665 -1 2.98983144659511 568 53 144 130 72 573 265 145 29 124 439 89 M17759 GO_MEDIATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEDIATOR_COMPLEX.html A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. 36/36 Gene Ontology CC GO:0016592 0.0138834184195474 0.0311438845627685 105 254.818181818182 144 0.00127016488159528 53 0.906956309283959 -0.927378008284235 -1 2.22170899654026 144 549 420 507 104 123 101 73 320 409 53 90 M17697 GO_MICROBODY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_PART.html Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 98/112 Gene Ontology CC GO:0044438 0.00954850014135904 0.02311532742554 145 135.727272727273 145 0.000871836034852615 5 1.06195736586682 -1.02910282377087 -1 2.83759773012279 145 5 250 54 77 149 237 65 66 287 158 91 M17576 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE.html The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 21/24 Gene Ontology CC GO:0031304 0.0258140907884895 0.0508406330444489 115 222.545454545455 146 0.00237473236686191 71 0.634021333584727 -0.663158715142057 -1 1.31510607546841 71 305 405 334 122 112 76 113 146 559 205 92 M17676 GO_NEUROMUSCULAR_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION.html The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. 91/122 Gene Ontology CC GO:0031594 0.00380032075582031 0.014153758712382 100 204.545454545455 146 0.000346081947308381 58 1.15293629860071 1.12033562547972 1 3.49238844927182 98 333 58 325 125 243 146 138 486 128 170 93 M17845 GO_COLLAGEN_TRIMER http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_TRIMER.html A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. 58/89 Gene Ontology CC GO:0005581 9.48845768221311e-12 3.67519594224388e-10 20 176.181818181818 146 8.62587062023094e-13 10 1.66093919284096 1.54534084330458 1 25.9660471353004 16 250 10 353 146 141 125 192 474 21 210 94 M17036 GO_NUCLEAR_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE.html The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. 21/30 Gene Ontology CC GO:0005640 0.00587715506162506 0.016106731560397 150 157.636363636364 147 0.000535719496914804 44 1.07305522423679 -1.06412193384562 -1 3.14720206129063 343 263 206 105 51 145 152 128 44 150 147 95 M17327 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE.html A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. 55/77 Gene Ontology CC GO:0045334 0.00684546676152297 0.0178350501723984 475 256.545454545455 148 0.000624260018426215 20 1.14957102951632 -1.06688798703158 -1 3.29046488768586 473 20 114 75 59 445 385 512 133 148 458 96 M17774 GO_COATED_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_MEMBRANE.html A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. 95/109 Gene Ontology CC GO:0048475 0.00191970288268968 0.0085864067738265 280 186.545454545455 148 0.000174670913611153 6 0.927218826865363 -0.856869662628945 -1 3.13363819041944 276 6 371 148 19 144 281 238 104 378 87 97 M16984 GO_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX.html A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants). 350/559 Gene Ontology CC GO:0031012 1.05167458763472e-41 6.11022935415774e-39 5 170.363636363636 150 9.5606780694066e-43 1 1.57717268022183 1.5661745783087 1 100 15 319 1 348 220 161 111 122 424 3 150 98 M17847 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. 32/39 Gene Ontology CC GO:0000307 0.00600555320271044 0.0163047963120316 60 190.272727272727 150 0.00054745546101879 20 0.80833022179772 0.857452101365741 1 2.3521736578566 57 302 321 292 150 61 20 54 345 392 99 99 M17647 GO_MAIN_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAIN_AXON.html The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. 68/108 Gene Ontology CC GO:0044304 0.000166149152514674 0.00138142497608269 155 184.090909090909 151 1.51056092558796e-05 16 1.36845325336379 1.30402943125763 1 6.44946672153975 224 16 42 70 319 152 151 480 142 54 375 100 M17568 GO_PRESYNAPTIC_ACTIVE_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_ACTIVE_ZONE.html A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. 21/44 Gene Ontology CC GO:0048786 0.00136588811796711 0.00678274356016147 30 170.818181818182 152 0.000124248807153603 26 1.62066835025715 -1.930587318883 -1 5.78754289042072 290 214 72 93 29 226 355 26 307 115 152 101 M17461 GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the inner mitochondrial membrane. 105/124 Gene Ontology CC GO:0098800 9.68132678914976e-08 2.2499403457984e-06 5 182.818181818182 153 8.80120655926052e-09 2 0.580390384204377 -0.581205875085293 -1 5.39474845397941 2 184 478 219 135 34 27 103 192 484 153 102 M17686 GO_RUFFLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE.html Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. 232/276 Gene Ontology CC GO:0001726 0.043177960463729 0.0791421419102439 275 206.181818181818 154 0.00400449340273342 56 1.08132830124427 1.18527057353247 1 1.93077840108682 271 85 137 56 154 367 253 283 121 96 445 103 M17232 GO_ORGANELLE_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. 527/618 Gene Ontology CC GO:0019866 0.00512637732421699 0.0159754589133247 20 191.181818181818 155 0.000513824174766953 20 0.808551684441932 -0.715095975370829 -1 2.36472524332134 20 232 521 155 74 58 66 137 166 479 195 104 M17240 GO_POTASSIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_COMPLEX.html An ion channel complex through which potassium ions pass. 57/123 Gene Ontology CC GO:0034705 9.91862656986936e-07 1.98775460153735e-05 155 183.454545454545 155 9.01693731059261e-08 20 1.45895654481386 -1.56828428192672 -1 11.3400063111594 155 249 20 309 488 100 190 25 375 50 57 105 M17258 GO_CYTOSOLIC_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PROTEASOME_COMPLEX.html A proteasome complex found in the cytosol of a cell. 13/14 Gene Ontology CC GO:0031597 0.0451349568842041 0.0819481560928831 95 194.545454545455 156 0.00418985836646955 25 0.581546454338237 -0.626913691068324 -1 1.00226352797519 65 221 365 251 156 95 92 135 25 522 213 106 M17738 GO_MITOCHONDRIAL_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ENVELOPE.html The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. 713/833 Gene Ontology CC GO:0005740 0.0612695022708952 0.1053182864479 155 233.909090909091 156 0.00630273897069241 32 0.848105203307722 -0.738863698826525 -1 1.32959725430594 32 156 571 154 451 70 96 154 180 471 238 107 M17595 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE.html A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. 40/42 Gene Ontology CC GO:0030140 0.00414528101165072 0.0151105807321266 290 151.454545454545 157 0.000377555663035966 27 1.04637558914631 -0.988606021304631 -1 3.1159542292922 289 27 218 116 37 190 231 44 157 213 144 108 M17519 GO_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of a membrane. 882/1255 Gene Ontology CC GO:0098796 0.0202840875986968 0.0425453245301186 95 215.909090909091 158 0.00204716515791653 27 1.03271092711458 -0.937636962974501 -1 2.30396833835193 104 67 550 158 351 27 91 242 347 343 95 109 M17593 GO_CIS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. 49/52 Gene Ontology CC GO:0005801 0.0558784967789708 0.0979860387254197 215 164.363636363636 158 0.00521367139707645 12 1.02784699117827 -0.983531067364811 -1 1.67472094779533 215 23 258 58 279 158 142 361 12 230 72 110 M17451 GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. 66/89 Gene Ontology CC GO:0012507 0.0058154695418106 0.0160132123402463 365 202.818181818182 160 0.000530081750746198 50 1.03533823950062 -0.926221470150601 -1 3.03929062131302 91 298 237 320 50 88 115 160 363 361 148 111 M17190 GO_CLATHRIN_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE.html A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. 170/208 Gene Ontology CC GO:0030136 0.00656581054798268 0.0173660967836959 400 217.181818181818 162 0.000598680746354343 56 1.12957906456516 -1.09499805516987 -1 3.25413000372746 397 91 141 147 56 199 397 341 298 160 162 112 M17271 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. 22/48 Gene Ontology CC GO:0034364 0.00660569258037312 0.0173660967836959 335 199 162 0.000602328229870644 41 1.50651934892346 1.4605445358228 1 4.35556718925862 333 41 67 92 58 490 201 108 246 162 391 113 M17347 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. 14/16 Gene Ontology CC GO:0033178 0.00728857363371987 0.0188207168052944 60 232.727272727273 162 0.000664803016900787 50 0.944991775666974 -0.480534715457573 -1 2.65995778057956 430 56 252 113 60 162 138 511 50 289 499 114 M17055 GO_ZYMOGEN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_GRANULE.html A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. 21/28 Gene Ontology CC GO:0042588 0.00525067012400144 0.0159754589133247 165 159.454545454545 163 0.000478476705861553 46 1.28652679711176 -1.45206996081652 -1 3.79015172719886 86 213 161 250 46 182 268 68 163 195 122 115 M17110 GO_SCF_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). 35/37 Gene Ontology CC GO:0019005 0.0442680379435263 0.0806261129943221 65 160.181818181818 165 0.00410770200468363 28 0.867916218585888 -0.876156619984471 -1 1.52890661515418 77 28 241 191 390 63 165 181 109 256 61 116 M17416 GO_RUFFLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_MEMBRANE.html The portion of the plasma membrane surrounding a ruffle. 127/146 Gene Ontology CC GO:0032587 0.0525176943519195 0.0933112551023401 265 177.636363636364 165 0.00489226795308109 66 1.17530596009654 1.33503296163544 1 1.96308122807442 265 96 92 66 165 327 223 226 153 79 262 117 M17253 GO_MOTILE_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM.html A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles. 90/165 Gene Ontology CC GO:0031514 0.113266154895571 0.168737528190582 285 206.181818181818 166 0.0108687224540793 70 1.03563711266274 -1.10373172505194 -1 1.28197036109112 284 101 200 127 471 81 242 380 70 166 146 118 M17579 GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX.html A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. 23/27 Gene Ontology CC GO:0032806 0.0237093626713807 0.0473372498696639 120 220.363636363636 166 0.00217898190559542 21 0.857265951999492 0.901508208734572 1 1.83868395747063 120 483 375 304 242 166 68 98 21 404 143 119 M17592 GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX.html A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. 4/20 Gene Ontology CC GO:0005892 0.00043661900284656 0.00285028809723428 230 232.454545454545 166 4.36704812845292e-05 12 0.635765189219692 0.515308675091634 1 2.63943800820008 227 59 555 37 99 579 166 12 28 562 233 120 M17098 GO_EXOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE.html A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. 150/211 Gene Ontology CC GO:0070382 0.000986366560852496 0.00519119411463313 330 175.818181818182 167 8.97099158675898e-05 20 1.18173829180187 -1.3011328954607 -1 4.43530148042047 330 178 148 111 124 206 386 20 243 167 21 121 M17398 GO_EXTRACELLULAR_MATRIX_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_COMPONENT.html Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). 144/171 Gene Ontology CC GO:0044420 7.01569081930292e-17 8.15223273202999e-15 170 187.090909090909 167 6.37790074482082e-18 3 1.52522240259535 1.48436065457154 1 35.6236727778375 13 365 3 350 255 167 119 126 481 10 169 122 M17136 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. 19/26 Gene Ontology CC GO:0033177 0.0216503754245277 0.0442917891607416 55 218.909090909091 168 0.0019878564538296 40 0.509591114101932 -0.538834668399111 -1 1.0985323743913 55 268 336 372 137 73 40 100 479 380 168 123 M17559 GO_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_COMPLEX.html Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 265/450 Gene Ontology CC GO:0043235 5.07993020720929e-11 1.73614085316976e-09 85 172.363636363636 169 4.61811837029691e-12 12 1.30129927146087 1.33145076012823 1 18.8770098937705 81 169 12 188 530 179 143 163 215 19 197 124 M17051 GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the cytoplasm. 14/16 Gene Ontology CC GO:0000153 9.17182316767402e-05 0.000918763665589415 140 237.272727272727 172 8.33836869478813e-06 3 0.6431761568343 -0.6431761568343 -1 3.1956979203809 140 498 358 419 3 110 41 172 282 503 84 125 M17105 GO_CELL_CORTEX_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_PART.html Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 143/185 Gene Ontology CC GO:0044448 0.00577426225782821 0.0159754589133247 175 220.181818181818 172 0.000526315789473684 34 1.01437375612063 -1.06819487111385 -1 2.97853174529295 382 95 182 34 152 172 416 235 437 145 172 126 M17521 GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. 12/14 Gene Ontology CC GO:0031235 0.00557211095868469 0.0159754589133247 175 185.727272727273 173 0.000507843102148426 51 1.01380231540118 1.13989677288681 1 2.97682758389651 173 136 235 172 317 241 157 51 68 274 219 127 M17057 GO_ENDOSOME_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_LUMEN.html The volume enclosed by the membrane of an endosome. 24/42 Gene Ontology CC GO:0031904 0.00483510625243632 0.0159754589133247 455 213.909090909091 174 0.000440524140245892 13 1.70170608695191 -2.04671347403927 -1 5.02830731230862 454 119 100 26 43 488 303 366 13 174 267 128 M17490 GO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION.html A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 1734/2090 Gene Ontology CC GO:0005739 0.0563818020819692 0.0980999288816959 150 227.727272727273 175 0.00578655760845742 52 0.917632118026462 -0.843833414313254 -1 1.4893822214355 52 146 546 236 322 57 99 149 248 475 175 129 M17235 GO_GOLGI_CISTERNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA.html Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. 115/145 Gene Ontology CC GO:0031985 0.00501685700517799 0.0159754589133247 255 179.636363636364 178 0.000457121277381913 45 1.22746739579401 -1.07924757095476 -1 3.61402365582285 252 290 178 218 45 55 207 416 132 120 63 130 M17635 GO_CELL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_BODY.html The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. 535/774 Gene Ontology CC GO:0044297 0.00190094788962101 0.0085864067738265 175 220.181818181818 178 0.00019025759713609 40 1.25631495873233 1.18069881118966 1 4.26237779890575 175 234 561 63 172 151 178 286 198 40 364 131 M17281 GO_PROTEIN_DNA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX.html A macromolecular complex containing both protein and DNA molecules. 110/191 Gene Ontology CC GO:0032993 0.0120579620229992 0.0280227037414501 180 200.181818181818 179 0.00110223291005074 32 1.21393898510351 -1.4567694108242 -1 3.08187886418982 96 185 171 277 385 194 368 139 179 176 32 132 M17195 GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION.html Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. 28/43 Gene Ontology CC GO:0098636 0.000596443912389156 0.00353606033773571 210 186.818181818182 180 5.42368796562136e-05 15 1.43813081647036 1.50766794822537 1 5.80576404343221 107 206 70 206 566 240 180 15 87 135 243 133 M17369 GO_PLATELET_DENSE_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet dense granule. 9/15 Gene Ontology CC GO:0031089 0.000204835856330229 0.00162257703186564 170 218.545454545455 181 2.04854739757628e-05 7 1.27662837427624 -0.991510318400498 -1 5.86549257776879 170 224 531 283 7 129 79 463 263 74 181 134 M17725 GO_ACTIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT.html A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. 93/112 Gene Ontology CC GO:0005884 0.135956235456209 0.192659933658677 135 209.545454545455 186 0.0131968620120496 100 0.943363780694279 0.940659707472001 1 1.07343395756671 135 100 204 140 272 323 183 186 276 153 333 135 M17277 GO_PARANODE_REGION_OF_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARANODE_REGION_OF_AXON.html An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. 18/35 Gene Ontology CC GO:0033270 0.0573734033888338 0.0995043205042162 235 209.909090909091 187 0.005356968057437 46 1.13385715885893 -1.28988221138188 -1 1.83968118811715 234 46 124 71 454 280 476 133 187 214 90 136 M17808 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX.html A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. 22/28 Gene Ontology CC GO:0045259 0.0146810590349841 0.0323094518913854 30 217.545454545455 188 0.00134363217937141 26 0.535317666976485 -0.528274626484138 -1 1.27807597200486 26 210 338 265 145 45 33 136 428 579 188 137 M17582 GO_RECYCLING_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a recycling endosome. 47/51 Gene Ontology CC GO:0055038 0.00413237073108224 0.0151105807321266 105 175.181818181818 189 0.000376377567665834 34 1.08631687890819 1.24802991009152 1 3.23667055569987 105 251 225 205 34 165 105 218 129 189 301 138 M17457 GO_XY_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XY_BODY.html A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. 21/32 Gene Ontology CC GO:0001741 0.00487891979529759 0.0159754589133247 140 184.727272727273 190 0.000444524858541502 25 1.22415069821022 -1.32325732971755 -1 3.60413253712309 138 260 190 202 315 384 279 48 40 151 25 139 M17407 GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE.html The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 53/65 Gene Ontology CC GO:0031228 0.00739004882781298 0.0189146183654597 65 180.545454545455 192 0.000674090019097156 59 1.14489601699863 -1.25689809380403 -1 3.22838724219743 229 197 155 259 63 177 192 63 398 194 59 140 M17455 GO_NUCLEAR_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE_PART.html Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. 13/16 Gene Ontology CC GO:0044453 0.00207440925062094 0.00887334256847125 505 237.636363636364 193 0.000188760711331268 7 1.07314994968102 0.997453701455591 1 3.60872438961814 504 55 184 67 21 562 269 193 7 217 535 141 M17111 GO_CD40_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD40_RECEPTOR_COMPLEX.html A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. 15/16 Gene Ontology CC GO:0035631 0.182150929965242 0.248720725751079 425 269.727272727273 194 0.0181137084322736 26 1.24176133731467 -1.61488564420114 -1 1.19906009032049 425 52 167 194 349 580 551 289 26 183 151 142 M17522 GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK.html The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. 957/1316 Gene Ontology CC GO:0042175 0.116397741365716 0.171207817046787 195 223.272727272727 195 0.0122985718426556 80 1.07065549939937 -0.979552542104485 -1 1.31567432487718 195 152 551 80 249 91 210 300 279 171 178 143 M17825 GO_EXOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an exocytic vesicle 55/80 Gene Ontology CC GO:0099501 0.00201611233805201 0.00874150200304642 390 261.363636363636 195 0.000183451118813028 31 1.29035025474101 -1.45761124592584 -1 4.36245986245875 390 195 90 104 325 567 560 31 300 149 164 144 M17060 GO_EXCITATORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. 236/315 Gene Ontology CC GO:0060076 0.00563194122810299 0.0159754589133247 220 264.090909090909 196 0.000513310066543948 62 1.14458886877517 1.06590167970378 1 3.36686173415389 219 170 62 137 444 193 196 552 354 83 495 145 M17505 GO_SECRETORY_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_MEMBRANE.html The lipid bilayer surrounding a secretory granule. 81/123 Gene Ontology CC GO:0030667 0.0766404712287422 0.126500323249714 205 231.636363636364 196 0.00722257261746354 101 1.19429440223761 -1.22008084170549 -1 1.73354722722482 201 103 101 173 191 356 470 190 365 196 202 146 M17813 GO_CENTRIOLAR_SATELLITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLAR_SATELLITE.html A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. 30/33 Gene Ontology CC GO:0034451 0.0130528999721623 0.029857223952072 150 227.454545454545 196 0.00119372673296348 33 0.942278496996196 -0.949943118696242 -1 2.3387089988079 148 380 305 421 161 109 160 206 196 383 33 147 M17818 GO_GAP_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION.html A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons. 19/35 Gene Ontology CC GO:0005921 0.0137714833428995 0.031012526442731 195 224.363636363636 196 0.00125985933879574 59 1.78169087814306 -1.9673885931531 -1 4.41481467256378 194 345 75 358 91 203 284 158 505 59 196 148 M17097 GO_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_PIT.html A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. 81/85 Gene Ontology CC GO:0005905 0.000539507555818042 0.00337047193473422 320 209.363636363636 197 4.9058173188933e-05 8 1.03763271517957 1.25977158190439 1 4.2118572232584 319 11 175 74 8 379 326 153 197 219 442 149 M17167 GO_PORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX.html Any small opening in a membrane that allows the passage of gases and/or liquids. 16/21 Gene Ontology CC GO:0046930 1.0105777004121e-05 0.000143206254619373 390 268.909090909091 197 9.18711220514539e-07 1 1.43552710324641 -0.619761206282356 -1 9.11354477929531 389 129 80 161 1 506 377 562 134 197 422 150 M17135 GO_CELL_PROJECTION_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_CYTOPLASM.html All of the contents of a cell projection, excluding the plasma membrane surrounding the projection. 59/73 Gene Ontology CC GO:0032838 0.00187399940045838 0.00857317835957733 115 211.909090909091 198 0.000170508873906836 7 1.11675967006889 -1.04845764418241 -1 3.78496995296117 111 538 294 327 120 40 85 198 305 306 7 151 M17255 GO_MICROVILLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS.html Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. 91/118 Gene Ontology CC GO:0005902 0.000317188157652506 0.00224739414141592 200 233.727272727273 198 2.88394452675638e-05 47 1.42349761153513 1.443856982311 1 6.21134336335338 198 189 47 258 554 372 139 203 111 70 430 152 M17473 GO_INTERSTITIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTITIAL_MATRIX.html A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. 16/18 Gene Ontology CC GO:0005614 0.0139861815031279 0.0312537363589127 75 236.181818181818 198 0.00127962692154176 69 1.35535269483882 1.27148060419879 1 3.33969029829765 69 394 73 447 430 245 132 74 431 105 198 153 M17479 GO_CHD_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHD_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. 20/23 Gene Ontology CC GO:0090545 0.00155436484534547 0.00740234405857146 390 257 199 0.000141405830675709 27 0.69434380682199 -0.613967662453022 -1 2.40919497199604 199 487 389 412 500 120 64 27 116 387 126 154 M17577 GO_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_COMPLEX.html Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. 35/52 Gene Ontology CC GO:0030286 0.000154220269425751 0.00135760570509638 305 169.454545454545 199 1.40210073951475e-05 5 0.938970961119253 -0.974017491893901 -1 4.42249665161506 305 32 199 284 5 216 226 59 136 328 74 155 M17649 GO_CHROMATOID_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATOID_BODY.html A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). 8/15 Gene Ontology CC GO:0033391 0.00172170968273451 0.00800250660535 160 225.727272727273 199 0.00017230450669933 18 0.882679181572153 0.828162437004076 1 3.0256898217641 156 279 563 199 18 290 124 439 90 225 100 156 M17090 GO_MHC_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. 30/50 Gene Ontology CC GO:0042611 0.0212130235500018 0.0441833328409351 50 209.727272727273 200 0.00194730636410015 46 1.10640998861039 -0.982354258647576 -1 2.44157989094656 46 382 180 269 109 49 200 231 433 297 111 157 M17729 GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. 23/29 Gene Ontology CC GO:0031233 9.54736953380271e-05 0.000940173169345657 560 243.454545454545 200 8.67980353404975e-06 26 1.7231402593579 -1.60132377433213 -1 8.61118157355411 556 117 38 83 294 376 484 200 31 26 473 158 M17575 GO_AUTOPHAGOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_MEMBRANE.html The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. 27/34 Gene Ontology CC GO:0000421 4.68441731844844e-05 0.000544329292403709 295 208.272727272727 201 4.25865187801006e-06 1 0.872889168055665 -0.915186079648281 -1 4.6830936344358 127 384 291 318 201 53 123 176 293 324 1 159 M17064 GO_DNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_COMPLEX.html A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. 13/13 Gene Ontology CC GO:0042575 0.0023724608152608 0.00991654484652177 205 191.545454545455 202 0.000215911193235734 34 1.01058089713952 -1.34993307453236 -1 3.31462672818328 202 355 300 377 132 113 51 34 205 282 56 160 M17684 GO_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENVELOPE.html A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. 1138/1396 Gene Ontology CC GO:0031975 0.0891383113137676 0.141888654447394 70 243.272727272727 203 0.00929297262617976 67 0.892544925960946 -0.795418746727187 -1 1.20992179104724 67 228 568 185 386 75 113 207 168 476 203 161 M17713 GO_SWI_SNF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_COMPLEX.html A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. 13/15 Gene Ontology CC GO:0016514 0.0219263684446146 0.0446036106268919 270 200 203 0.00201345426621231 2 0.81129164162613 -0.507899508313974 -1 1.77237048332795 266 222 278 203 110 150 135 195 2 346 293 162 M17215 GO_NEURONAL_POSTSYNAPTIC_DENSITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_POSTSYNAPTIC_DENSITY.html A postsynaptic density that is part of a neuron. 73/96 Gene Ontology CC GO:0097481 0.104792338803043 0.160644719906511 145 242.454545454545 204 0.0100131281723055 102 1.17569438015012 1.04854453915704 1 1.5032947076273 261 107 102 204 221 184 145 414 443 142 444 163 M17226 GO_U2_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U2. 19/24 Gene Ontology CC GO:0005686 0.0667707864545184 0.1134322424856 310 251.636363636364 205 0.00626252943502763 103 0.487787477567381 -0.465580335305563 -1 0.71884015241066 103 308 423 317 183 135 131 205 137 520 306 164 M17263 GO_NEURON_SPINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_SPINE.html A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. 165/235 Gene Ontology CC GO:0044309 1.62088744718181e-05 0.000214030819730144 150 202.727272727273 205 1.47354489951742e-06 32 1.21844572197776 1.16672441318886 1 7.37537816414129 147 92 32 65 342 205 215 483 329 72 248 165 M17012 GO_IMMUNOLOGICAL_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE.html An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 36/68 Gene Ontology CC GO:0001772 0.0902093001393118 0.143201102133716 385 279.272727272727 206 0.0085577815691949 115 1.0062384704091 0.873982762077703 1 1.36329407076845 384 115 166 171 206 214 147 496 420 186 567 166 M17245 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX.html A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. 42/53 Gene Ontology CC GO:0016469 0.027163018572782 0.0531370834706611 55 229 206 0.00250039180396826 43 0.672792422220677 -0.534374125251475 -1 1.37694488647545 54 201 368 266 553 50 43 213 171 394 206 167 M17717 GO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOST.html Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. 17/20 Gene Ontology CC GO:0018995 0.00353011808249678 0.0134934118811225 190 214 206 0.000321435933130661 31 0.986714214086519 -1.00536819004374 -1 3.01615609718042 294 128 214 96 31 248 285 472 190 206 190 168 M17626 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT.html A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. 141/169 Gene Ontology CC GO:0005793 0.00254969049993839 0.0105061714926539 405 258.363636363636 207 0.000232059115250031 23 1.15428772527612 -1.07974761646857 -1 3.74453056676511 404 181 130 192 23 207 381 521 229 188 386 169 M17251 GO_COMPACT_MYELIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPACT_MYELIN.html The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. 23/26 Gene Ontology CC GO:0043218 0.00273212271621474 0.0110078632109526 145 191 208 0.00024868377991724 26 1.20047287990044 0.96927328894557 1 3.85584846968229 340 212 208 144 26 350 144 79 73 299 226 170 M17438 GO_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the Golgi apparatus. 761/943 Gene Ontology CC GO:0000139 0.0173523120599446 0.0371100384062253 470 269.363636363636 208 0.00174893163567265 47 1.09735875592127 -1.04264483910292 -1 2.55924139633628 468 69 540 47 105 168 420 526 208 232 180 171 M17302 GO_BASEMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE.html A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. 112/132 Gene Ontology CC GO:0005604 4.72697620628734e-13 2.74637317585295e-11 25 205.363636363636 209 4.29725109662579e-14 6 1.4806645397764 1.41008380035356 1 25.9115316923215 22 330 6 355 270 209 150 187 458 12 260 172 M17629 GO_NEURON_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a neuron projection. 46/74 Gene Ontology CC GO:0032589 0.000129676697637338 0.00119590732265545 565 236.363636363636 209 1.17894856295815e-05 24 1.4438656548459 -1.43183227980097 -1 6.95755753556854 562 24 41 248 377 522 438 49 209 52 78 173 M17494 GO_DENDRITE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MEMBRANE.html The portion of the plasma membrane surrounding a dendrite. 22/37 Gene Ontology CC GO:0032590 0.00100071211848349 0.00519119411463313 210 218.090909090909 210 9.10152365122465e-05 53 1.52932329910127 1.69812296449866 1 5.75355056242209 210 121 53 286 387 181 87 420 369 69 216 174 M17584 GO_SPINDLE_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MICROTUBULE.html Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. 69/78 Gene Ontology CC GO:0005876 0.0156290686126675 0.0338824211341785 180 260.181818181818 210 0.00143101967442853 65 1.23951328313044 -1.32063331683842 -1 2.97811082936092 176 371 285 210 531 343 458 81 65 193 149 175 M17158 GO_APICAL_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_COMPLEX.html A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. 136/174 Gene Ontology CC GO:0043296 0.190796034063891 0.257796501839816 130 241.454545454545 211 0.0190618241550607 98 1.10566539232403 1.01635456917996 1 1.03397430962982 126 98 174 276 428 368 114 304 184 211 373 176 M17339 GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT.html The large subunit of a ribosome located in the cytosol. 69/129 Gene Ontology CC GO:0022625 0.0213470878572702 0.0441833328409351 40 301.181818181818 211 0.00195973469514056 39 0.666283673939655 0.59436084612297 1 1.45180867958286 39 544 488 581 175 82 59 89 578 467 211 177 M17239 GO_GOLGI_APPARATUS_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS_PART.html Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. 903/1202 Gene Ontology CC GO:0044431 0.00525070999993344 0.0159754589133247 520 275.727272727273 212 0.000526315789473684 5 1.13469969582 -1.09600874332221 -1 3.33737005423103 516 66 522 5 157 169 466 554 212 144 222 178 M17489 GO_MITOCHONDRIAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PART.html Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 988/1145 Gene Ontology CC GO:0044429 0.0630955843088241 0.107819219068902 220 221.363636363636 212 0.00649620909943559 34 0.854441024158283 -0.757177078523492 -1 1.32542148973913 34 151 545 216 280 60 94 143 219 481 212 179 M17334 GO_LEADING_EDGE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEADING_EDGE_MEMBRANE.html The portion of the plasma membrane surrounding the leading edge of a motile cell. 184/233 Gene Ontology CC GO:0031256 0.000709045826221 0.00403878063759217 260 193.272727272727 213 6.44794954806377e-05 32 1.27140957813829 1.37032524931389 1 5.00546933279737 259 90 51 64 213 315 229 320 185 32 368 180 M17439 GO_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a coated vesicle. 158/202 Gene Ontology CC GO:0030662 0.00462149108821891 0.0159754589133247 350 250 213 0.000421020727238087 41 1.03260301490322 -0.943755977933096 -1 3.03289538800443 347 175 213 115 41 185 302 546 338 325 163 181 M16988 GO_CYTOCHROME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX.html A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 18/29 Gene Ontology CC GO:0070069 0.0082908048054518 0.0205477894327546 65 213.545454545455 214 0.000756564994783258 42 0.613404185023913 -0.613404185023913 -1 1.67144765353977 42 266 276 264 107 51 65 61 507 496 214 182 M17077 GO_BASAL_LAMINA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_LAMINA.html A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. 40/46 Gene Ontology CC GO:0005605 3.0785087719072e-06 5.26062822493554e-05 45 214.727272727273 215 2.79864825431019e-07 25 1.68701715550761 1.5384562989711 1 11.9362662203891 43 338 25 333 204 263 174 215 406 47 314 183 M17147 GO_SEX_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_CHROMOSOME.html A chromosome involved in sex determination. 35/46 Gene Ontology CC GO:0000803 0.0468112452233068 0.0840421367346448 115 227.636363636364 215 0.00434890972770738 46 1.20560509727561 -1.2743107200201 -1 2.10582085549487 115 301 240 175 538 383 299 125 46 215 67 184 M17781 GO_CYTOSOLIC_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_RIBOSOME.html A ribosome located in the cytosol. 124/214 Gene Ontology CC GO:0022626 0.021445266542416 0.0441833328409351 40 283.818181818182 215 0.00196883725830528 40 0.935918977595685 0.920195181515873 1 2.05817383483541 40 534 486 495 171 108 60 90 454 469 215 185 M17198 GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE.html The membrane surrounding the outer segment of a vertebrate photoreceptor. 11/19 Gene Ontology CC GO:0042622 0.00657905526157408 0.0173660967836959 370 223.818181818182 216 0.000599892050864224 41 2.365739948394 2.13499937767266 1 6.86625006955179 370 399 132 314 57 197 216 174 41 263 299 186 M17310 GO_COMPLEX_OF_COLLAGEN_TRIMERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEX_OF_COLLAGEN_TRIMERS.html A complex of collagen trimers such as a fibril or collagen network. 28/30 Gene Ontology CC GO:0098644 5.50452361431577e-05 0.000627083964689698 25 220 216 5.00423758674007e-06 21 1.50640551055367 1.4029720638672 1 7.9620305447665 21 303 34 335 216 187 195 247 553 98 231 187 M17501 GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX.html Any of the heteromeric enzymes that act in the TCA cycle. 10/13 Gene Ontology CC GO:0045239 0.00227639275297621 0.00965389919327869 405 256.272727272727 217 0.000207159237174656 15 0.619960556818659 -0.619960556818659 -1 2.02742531400349 217 403 313 405 517 119 57 32 195 546 15 188 M17827 GO_ANCHORED_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 98/186 Gene Ontology CC GO:0031225 3.6546668296792e-15 3.44044806164108e-13 215 251.909090909091 217 3.32242439061746e-16 4 1.78640335186927 1.73813763439841 1 36.9121374377508 211 99 4 217 564 378 259 566 120 11 342 189 M17678 GO_SOMATODENDRITIC_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATODENDRITIC_COMPARTMENT.html The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. 721/1027 Gene Ontology CC GO:0036477 0.0016604838767149 0.00778017042234967 220 273.727272727273 218 0.000166172592611964 38 1.24224417780192 1.19606186150917 1 4.3024212079693 216 230 567 122 239 189 218 528 211 38 453 190 M17108 GO_GOLGI_STACK http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_STACK.html The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. 152/184 Gene Ontology CC GO:0005795 0.00946017905127393 0.0229973390325948 300 217.181818181818 220 0.000863736834915114 60 1.16464768495703 -1.07029102182615 -1 3.12078915163467 297 324 234 220 71 68 366 387 177 185 60 191 M17375 GO_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_COMPLEX.html A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. 41/74 Gene Ontology CC GO:0016459 0.0140944670168462 0.0313750396045503 135 282.454545454545 221 0.00128959841627787 75 1.00483458518474 0.961243387706173 1 2.46114192750876 132 426 205 473 136 413 221 75 482 220 324 192 M17638 GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. 26/29 Gene Ontology CC GO:0080008 0.00416126147528444 0.0151105807321266 225 212.545454545455 221 0.000379013939514415 14 0.681274401756803 -0.705548205202018 -1 2.01249276443976 131 385 406 425 225 14 18 82 221 415 16 193 M17637 GO_LYTIC_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE.html A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. 553/770 Gene Ontology CC GO:0000323 0.00525070999993344 0.0159754589133247 485 264.636363636364 222 0.000526315789473684 11 1.09185539441686 -0.977124707939483 -1 3.20959896263145 484 72 562 11 311 36 414 470 222 168 161 194 M17436 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_.html All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. 11/16 Gene Ontology CC GO:0045263 0.00456615946590253 0.0159726173488158 50 242 223 0.000415969480299723 17 0.479416682124531 -0.479416682124531 -1 1.38323405219901 47 278 299 370 167 66 17 148 508 539 223 195 M17763 GO_AXON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_PART.html A part of an axon, a cell projection of a neuron. 248/371 Gene Ontology CC GO:0033267 1.84121599389273e-06 3.47949026820383e-05 25 221.545454545455 223 1.67383412258029e-07 21 1.31637650239353 1.25396533730301 1 9.69590202400214 345 84 21 22 209 231 278 479 223 24 521 196 M17282 GO_APICAL_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_DENDRITE.html A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. 21/30 Gene Ontology CC GO:0097440 0.00577426225782821 0.0159754589133247 240 215.727272727273 224 0.000526315789473684 35 0.987386010929329 0.795639172049597 1 2.89804837761102 239 43 156 35 425 224 163 201 331 238 318 197 M17133 GO_ANAPHASE_PROMOTING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX.html A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. 23/24 Gene Ontology CC GO:0005680 0.10582504985941 0.161449411766878 180 259.363636363636 226 0.0101170052258459 167 0.65321959516975 -0.605423507018637 -1 0.812194395766356 180 211 353 226 417 220 206 167 252 349 272 198 M17050 GO_SAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_COMPLEX.html A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. 8/9 Gene Ontology CC GO:0000124 0.00368524602441532 0.0139034281830214 125 281 227 0.000369137179395145 15 0.856476172810676 0.856476172810676 1 2.59342143143633 95 455 514 477 169 124 15 121 392 502 227 199 M17353 GO_COPI_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE.html A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. 30/32 Gene Ontology CC GO:0030137 0.000104613282203204 0.00101300528266769 275 218.727272727273 227 9.5107506410941e-06 4 0.860123407165631 -0.877128998933613 -1 4.22877975599422 272 116 363 142 4 201 227 356 11 422 292 200 M17722 GO_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE.html Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. 369/538 Gene Ontology CC GO:0030133 0.00827243152792601 0.0205477894327546 435 244.909090909091 227 0.000754882021366529 67 1.12118707692017 -1.13252357299647 -1 3.0936279314884 435 283 147 262 67 198 430 227 328 175 142 201 M17305 GO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MATRIX.html The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. 443/496 Gene Ontology CC GO:0005759 0.0383172301171566 0.0720463129387313 30 235.909090909091 228 0.00354557625090845 30 0.828730150113017 -0.769612136869695 -1 1.52499592106493 30 316 502 275 148 64 90 194 270 478 228 202 M17755 GO_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REGION.html A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane. 1088/1581 Gene Ontology CC GO:0098589 4.19015461390986e-13 2.70497758964625e-11 230 240.909090909091 228 4.19015461391065e-14 6 1.26284927798546 1.31054566594281 1 22.106757657223 128 150 575 118 392 228 161 229 294 6 369 203 M17824 GO_SYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_MEMBRANE.html A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 218/356 Gene Ontology CC GO:0097060 0.000198443037265416 0.00160132506460009 160 229.090909090909 228 1.80419035783723e-05 45 1.26253754707661 1.21053874434986 1 5.81223823745312 228 239 45 131 269 160 156 489 277 64 462 204 M17628 GO_PLASMA_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_REGION.html A membrane that is a (regional) part of the plasma membrane. 883/1317 Gene Ontology CC GO:0098590 2.36985002617544e-12 1.14740238767328e-10 160 249.272727272727 229 2.36985002617796e-13 7 1.30943003997474 1.33204085812792 1 21.5598335964372 158 153 560 119 397 229 176 282 268 7 393 205 M17389 GO_ENDOCYTIC_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_LUMEN.html The volume enclosed by the membrane of an endocytic vesicle. 21/38 Gene Ontology CC GO:0071682 0.122469342508907 0.176562501234925 555 318.454545454545 230 0.0118064222608592 86 2.20847393242941 -1.68018978208598 -1 2.71432265008799 230 485 86 455 551 532 555 178 113 114 204 206 M17791 GO_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a transport vesicle. 154/216 Gene Ontology CC GO:0030658 0.0224100903466467 0.0452092447618116 230 236 230 0.00205833437002376 112 1.12316301474462 -1.1459983184744 -1 2.46066867764731 248 177 150 230 112 335 378 134 332 270 230 207 M17488 GO_VACUOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PART.html Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. 743/967 Gene Ontology CC GO:0044437 0.00525070999993344 0.0159754589133247 470 277.454545454545 231 0.000526315789473684 20 1.01268595926443 -0.928594235010033 -1 2.97349836536489 469 70 544 20 182 62 500 537 231 334 103 208 M17491 GO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE.html The external part of the cell wall and/or plasma membrane. 680/1190 Gene Ontology CC GO:0009986 4.14511814655551e-15 3.44044806164108e-13 185 272 231 4.14511814655553e-16 5 1.34341127086941 1.35484062481556 1 27.7471259828223 207 231 547 184 228 405 315 184 315 5 371 209 M17511 GO_MEMBRANE_MICRODOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_MICRODOMAIN.html A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. 360/491 Gene Ontology CC GO:0098857 8.86326877600956e-08 2.23893876472241e-06 170 253 232 8.05751739371752e-09 18 1.2003280148476 1.29593305267415 1 11.2110566153528 169 236 18 189 509 375 232 199 415 23 418 210 M17602 GO_NONMOTILE_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM.html A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 149/208 Gene Ontology CC GO:0031513 0.00577426225782821 0.0159754589133247 565 287.454545454545 232 0.000526315789473684 12 1.18251626162761 -1.13894770370473 -1 3.47996952743273 561 176 79 12 348 232 523 482 173 117 459 211 M17597 GO_INHIBITORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INHIBITORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. 9/20 Gene Ontology CC GO:0060077 0.000960070177605614 0.00511743828613635 270 240.545454545455 233 9.60485210622022e-05 13 0.968068758167353 -1.25385704242628 -1 3.63492627565459 267 141 556 89 13 404 323 43 527 233 50 212 M17139 GO_MYOFILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFILAMENT.html Any of the smallest contractile units of a myofibril (striated muscle fiber). 19/34 Gene Ontology CC GO:0036379 0.113899428520737 0.169246976906773 200 315.636363636364 234 0.0109329616930733 137 1.47001181123522 1.32206387596346 1 1.83599483138076 197 561 177 530 234 468 185 173 476 137 334 213 M17270 GO_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an endocytic vesicle. 162/230 Gene Ontology CC GO:0030666 0.00861229267713434 0.021040769815588 355 235.363636363636 234 0.00078601754294643 27 1.16518673063044 -1.11064283314059 -1 3.19694529207882 351 323 69 234 372 188 425 166 326 108 27 214 M17049 GO_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEMBRANE.html The lipid bilayer surrounding any membrane-bounded vesicle in the cell. 527/700 Gene Ontology CC GO:0012506 0.00525070999993344 0.0159754589133247 455 249.363636363636 235 0.000526315789473684 24 1.15597699065313 -1.13370539293195 -1 3.40082360810125 455 159 513 24 117 235 503 272 262 78 125 215 M17085 GO_CYTOPLASMIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_REGION.html Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\ 351/475 Gene Ontology CC GO:0099568 0.00577426225782821 0.0159754589133247 170 238.909090909091 235 0.000526315789473684 17 1.04077918421876 -1.11116140828924 -1 3.0572785158496 450 167 168 17 235 159 479 342 285 90 236 216 M17648 GO_LAMELLAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLAR_BODY.html A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. 17/26 Gene Ontology CC GO:0042599 0.0968242895795454 0.150817459103796 235 269.636363636364 235 0.00921529101324005 97 1.883159165064 -2.07597901957607 -1 2.52160188640634 232 310 159 209 452 170 235 419 422 261 97 217 M17414 GO_POSTSYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE.html A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. 158/268 Gene Ontology CC GO:0045211 0.00561239953044877 0.0159754589133247 145 228.363636363636 237 0.000511524419682875 61 1.19829466003655 1.21253615126871 1 3.52702416766212 141 288 61 281 361 125 126 450 348 94 237 218 M17477 GO_ENDOLYSOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME_MEMBRANE.html The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. 29/50 Gene Ontology CC GO:0036020 0.00356046637121116 0.0135204638017888 170 261.545454545455 239 0.00032420379069332 42 0.966353111534374 1.05686358443951 1 2.95156102069261 166 381 183 410 208 305 164 42 487 292 239 219 M17515 GO_PHOTORECEPTOR_CONNECTING_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CONNECTING_CILIUM.html A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments. 49/62 Gene Ontology CC GO:0032391 0.254611564148847 0.334681716675294 225 230 239 0.0263599661325903 88 1.04752090027522 1.10008684105036 1 0.780043754696905 222 111 211 132 282 258 239 469 88 267 251 220 M17367 GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 28/32 Gene Ontology CC GO:0031312 0.0390942242274279 0.0728004624235115 120 225.636363636364 240 0.0036187929582371 105 1.04996113501158 -0.930384713975862 -1 1.93664160786031 318 207 279 176 240 252 422 120 118 245 105 221 M17210 GO_OUTER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the outer mitochondrial membrane. 11/12 Gene Ontology CC GO:0098799 0.0630660957270258 0.107819219068902 90 273.636363636364 241 0.00590454822821116 67 0.55073381380695 -0.55073381380695 -1 0.837759346053855 88 400 350 411 241 102 67 162 462 518 209 222 M17771 GO_RECYCLING_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME.html An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. 147/172 Gene Ontology CC GO:0055037 0.412776052212369 0.496527714980096 230 260.272727272727 241 0.0472429745676569 98 1.06467157130482 1.0960302743655 1 0.490814015503371 226 179 246 98 332 317 189 359 228 241 448 223 M17833 GO_ORGANELLE_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_SUBCOMPARTMENT.html A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. 349/420 Gene Ontology CC GO:0031984 0.00577426225782821 0.0159754589133247 425 252.545454545455 241 0.000526315789473684 27 0.977173180601809 -0.943246185048456 -1 2.86759148050841 423 75 330 27 178 132 447 486 241 318 121 224 M17194 GO_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LUMEN.html The volume enclosed by the membrane or protein that forms a vesicle. 89/213 Gene Ontology CC GO:0031983 9.99768048671905e-06 0.000143206254619373 120 232.909090909091 242 9.08884174588138e-07 30 1.48057113923737 1.56580524133355 1 9.4009707516822 119 368 30 499 69 302 171 291 432 39 242 225 M17513 GO_TRANSPORTER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_COMPLEX.html A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. 208/394 Gene Ontology CC GO:1990351 3.88153676348579e-09 1.12758642979262e-07 415 271.818181818182 243 3.52866979121283e-10 15 1.22311165816157 -1.21080464459752 -1 14.0598922775816 412 172 15 308 577 127 359 243 442 103 232 226 M17634 GO_IKAPPAB_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IKAPPAB_KINASE_COMPLEX.html A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 10/12 Gene Ontology CC GO:0008385 0.136775045509087 0.193348665306033 365 282.363636363636 243 0.0132819116378201 58 0.603717126616395 -0.607328671364576 -1 0.668643170690238 363 137 308 228 243 533 314 225 58 564 133 227 M17264 GO_ENDOPLASMIC_RETICULUM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_PART.html Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. 1099/1512 Gene Ontology CC GO:0044432 0.0112278962937298 0.0264105576787733 310 227.363636363636 245 0.00112850325552342 55 1.12418053045545 -1.02720943956641 -1 2.89858270480093 306 64 525 79 180 138 296 344 245 55 269 228 M17304 GO_BRUSH_BORDER http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER.html The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. 117/186 Gene Ontology CC GO:0005903 0.322730900824258 0.405858557097173 155 253 245 0.0348058964589072 119 1.16723608907493 1.09266102668959 1 0.712252525717973 152 245 119 364 479 329 141 319 218 165 252 229 M17798 GO_BASAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PART_OF_CELL.html The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. 63/84 Gene Ontology CC GO:0045178 0.00130205106983754 0.00652147992737596 120 231.818181818182 245 0.000118438392424854 33 1.40649943882353 1.47149464675293 1 5.056404870136 116 192 60 310 557 358 245 262 135 33 282 230 M17178 GO_PRECATALYTIC_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRECATALYTIC_SPLICEOSOME.html A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. 22/27 Gene Ontology CC GO:0071011 0.0428761076000447 0.0790825984623047 65 235.363636363636 246 0.0039759328534723 56 0.530774440264779 -0.543991959192127 -1 0.924316244650226 64 262 422 341 246 92 56 180 154 513 259 231 M17826 GO_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of acetyltransferase activity. 100/110 Gene Ontology CC GO:1902493 0.0213037083539696 0.0441833328409351 65 276.181818181818 246 0.00195571306145406 63 0.801471365158333 0.69937193602843 1 1.75582341453248 63 464 482 514 160 118 82 88 395 426 246 232 M17285 GO_STEREOCILIUM_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEREOCILIUM_BUNDLE.html A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. 48/77 Gene Ontology CC GO:0032421 0.03057524274824 0.0582433312679588 200 291.636363636364 247 0.00281896624632233 92 1.3014360824026 -1.32625622858077 -1 2.62094592458933 501 199 142 247 360 479 534 110 92 199 345 233 M17257 GO_DENDRITIC_SHAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SHAFT.html Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. 47/67 Gene Ontology CC GO:0043198 0.000915628821831628 0.00496276715429389 255 227.454545454545 249 8.32736476443605e-05 18 1.17303981335404 -1.31392215364447 -1 4.44036680879095 385 252 120 177 139 249 338 18 405 253 166 234 M17743 GO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM.html The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). 1541/2134 Gene Ontology CC GO:0005783 0.00140221462559081 0.00690412455481576 325 219.727272727273 249 0.000140310020478293 2 1.12255824739031 -1.04917840711675 -1 3.98008754720013 324 61 573 2 141 130 318 330 254 35 249 235 M17035 GO_BASOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASOLATERAL_PLASMA_MEMBRANE.html The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 220/324 Gene Ontology CC GO:0016323 1.97367574227497e-09 6.37058670145421e-08 15 275.727272727273 250 1.79425067640509e-10 13 1.38557346468324 1.42278782134144 1 16.5039395103236 250 171 13 190 544 444 337 405 194 14 471 236 M17701 GO_PERICENTRIOLAR_MATERIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIOLAR_MATERIAL.html A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. 23/25 Gene Ontology CC GO:0000242 0.00577426225782821 0.0159754589133247 260 198.090909090909 250 0.000526315789473684 36 0.9640306429666 -1.06087423995891 -1 2.82839755447753 257 42 256 36 177 250 254 338 54 350 165 237 M17468 GO_FILOPODIUM_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_TIP.html The end of a filopodium distal to the body of the cell. 28/35 Gene Ontology CC GO:0032433 0.182794750250793 0.248720725751079 505 286.545454545455 251 0.0181840019786727 179 1.01448746786185 -1.00794688013008 -1 0.971081254304754 502 205 191 179 263 360 478 219 251 208 296 238 M17583 GO_ORGANELLE_ENVELOPE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ENVELOPE_LUMEN.html The region between the inner and outer lipid bilayers of an organelle envelope. 95/115 Gene Ontology CC GO:0031970 0.00575810203756003 0.0159754589133247 200 251.727272727273 251 0.000524838934858916 49 0.865652846794492 -0.819571796019834 -1 2.53501341716138 196 187 290 242 49 251 297 277 232 358 390 239 M17740 GO_CELL_LEADING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_LEADING_EDGE.html The area of a motile cell closest to the direction of movement. 448/544 Gene Ontology CC GO:0031252 0.0714857714432015 0.119909439383893 75 254.272727272727 251 0.00672000763250063 49 1.09171827950389 1.14457728324292 1 1.62277005017817 299 74 107 49 251 508 334 378 217 71 509 240 M17662 GO_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE.html Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. 282/351 Gene Ontology CC GO:0030135 0.00277793551905063 0.0110179654000479 440 265.727272727273 252 0.000252859038722527 27 1.0570086852491 -1.00060689250271 -1 3.38878751200452 438 82 194 252 27 176 404 560 360 290 140 241 M17076 GO_MICROBODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_MEMBRANE.html The lipid bilayer surrounding a microbody. 64/69 Gene Ontology CC GO:0031903 0.0462581541880938 0.0837258180164564 255 222.818181818182 253 0.00429640267046281 18 1.02593048973575 -0.996492932198898 -1 1.7878357333764 388 18 254 68 231 256 433 124 97 329 253 242 M17828 GO_MHC_CLASS_I_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_COMPLEX.html A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. 22/39 Gene Ontology CC GO:0042612 0.115333948321651 0.170941387691019 70 304.181818181818 253 0.0110786337894383 66 0.660893779005316 -0.660893779005316 -1 0.795064134508944 66 557 297 441 229 114 170 253 576 399 244 243 M17242 GO_COPI_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a COPI-coated vesicle. 20/20 Gene Ontology CC GO:0030663 0.000166436744106349 0.00138142497608269 330 228.818181818182 255 1.51317578990935e-05 6 1.074866979054 -1.26128539732317 -1 5.0558186594968 320 216 328 114 6 222 255 326 14 385 331 244 M17209 GO_NPBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NPBAF_COMPLEX.html A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. 14/15 Gene Ontology CC GO:0071564 0.0811859513614267 0.13175708866198 245 281.545454545455 256 0.00766786153468103 140 0.507899508313974 -0.507899508313974 -1 0.695565119286666 243 311 394 302 419 140 177 147 256 517 191 245 M17381 GO_CLATHRIN_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_VESICLE_COAT.html A clathrin coat found on a vesicle. 29/32 Gene Ontology CC GO:0030125 0.00562315966535702 0.0159754589133247 365 223 257 0.00051250763640927 10 0.903983561974519 -0.819768760941805 -1 2.6493240059667 459 29 229 41 48 346 363 362 10 257 309 246 M17598 GO_MICROTUBULE_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_END.html Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. 27/27 Gene Ontology CC GO:1990752 0.140880899411581 0.198669423684778 325 263.909090909091 257 0.0137094948928981 37 1.10968892453439 -1.31511692929543 -1 1.24632735142675 322 478 287 214 465 257 282 188 37 239 134 247 M17465 GO_APICOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICOLATERAL_PLASMA_MEMBRANE.html The apical end of the lateral plasma membrane of epithelial cells. 23/27 Gene Ontology CC GO:0016327 0.540939736167045 0.61745773421032 245 327.818181818182 258 0.068332637218388 160 1.36168712673875 -1.38869506275709 -1 0.426750867019213 245 258 160 222 503 514 182 538 244 259 481 248 M17608 GO_PHAGOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a phagocytic vesicle. 74/111 Gene Ontology CC GO:0030670 0.0810920753479574 0.13175708866198 260 286 258 0.00765864492458735 85 0.98528087962933 -0.992368543002889 -1 1.39309160676711 258 415 232 436 473 156 252 204 367 268 85 249 M17391 GO_MICROTUBULE_PLUS_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_PLUS_END.html The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. 22/22 Gene Ontology CC GO:0035371 0.00577426225782821 0.0159754589133247 260 298.818181818182 259 0.000526315789473684 23 1.09947662855955 -1.33986285668789 -1 3.23232715223557 490 259 263 43 450 471 539 246 23 247 256 250 M17029 GO_KINESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_COMPLEX.html Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. 51/57 Gene Ontology CC GO:0005871 0.0920995013349679 0.145407093140262 260 262.272727272727 260 0.00874521702605068 42 1.2871924616872 -1.35720014584225 -1 1.74275439887013 260 422 203 224 265 348 313 502 42 212 94 251 M17356 GO_PERICENTRIC_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIC_HETEROCHROMATIN.html Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. 17/18 Gene Ontology CC GO:0005721 0.0170019055141577 0.0367215877461919 125 258.454545454545 261 0.00155770345542239 36 1.33363500402467 -1.33363500402467 -1 3.13042128177446 122 496 309 485 261 77 36 217 313 370 157 252 M17625 GO_T_TUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_TUBULE.html Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. 57/87 Gene Ontology CC GO:0030315 0.000527771613229128 0.00333299247050134 305 253.272727272727 261 4.79907514696553e-05 50 1.29808399848294 -1.27462652632044 -1 5.29120510036695 303 193 50 197 435 261 121 305 317 88 516 253 M17848 GO_VACUOLAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_MEMBRANE.html The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. 648/795 Gene Ontology CC GO:0005774 0.0836499377450194 0.135001705082934 465 298.818181818182 261 0.00869763711937739 72 0.98441583138382 -0.882667708961467 -1 1.3745629031371 461 157 581 99 223 72 463 477 261 373 120 254 M17010 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX.html A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. 30/54 Gene Ontology CC GO:0005891 0.0524164679030041 0.0933112551023401 555 312.363636363636 264 0.00488260345687939 68 1.18573099024017 1.09438074284016 1 1.98090679690325 90 553 71 537 552 236 234 266 565 264 68 255 M17116 GO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE.html A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. 1232/1632 Gene Ontology CC GO:0005773 0.00525070999993344 0.0159754589133247 520 279.454545454545 264 0.000526315789473684 6 1.05241250280554 -0.975409906989651 -1 3.09197162009169 520 63 516 6 333 48 501 532 264 178 113 256 M17005 GO_LYSOSOMAL_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_LUMEN.html The volume enclosed within the lysosomal membrane. 93/120 Gene Ontology CC GO:0043202 0.010246560279108 0.0244989774574557 520 282.272727272727 265 0.000935872494167567 9 1.02821961910841 -0.976583614545249 -1 2.70287644051153 519 9 103 87 75 265 462 533 397 240 415 257 M17091 GO_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. 467/581 Gene Ontology CC GO:0015629 0.157828503228278 0.219900144785682 430 318.272727272727 265 0.0154943093650769 123 1.00844365800307 1.01027566559791 1 1.05455446092351 429 161 265 123 252 465 510 386 239 131 540 258 M17783 GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX.html A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. 20/24 Gene Ontology CC GO:0000159 0.109446658739078 0.164706433255721 195 248.909090909091 265 0.010482155048794 71 0.722469180767211 0.930094173604004 1 0.892829877315214 192 265 315 294 522 274 102 170 71 332 201 259 M17059 GO_LATE_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a late endosome. 110/129 Gene Ontology CC GO:0031902 0.00489898958459804 0.0159754589133247 205 256.545454545455 266 0.000446357531979829 19 0.835725379009268 -0.780144151483343 -1 2.44576315277383 203 411 469 423 68 52 272 209 266 430 19 260 M17474 GO_EXTRACELLULAR_SPACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_SPACE.html That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. 1040/2139 Gene Ontology CC GO:0005615 4.22796854999667e-28 6.14112431887016e-26 85 255.363636363636 266 4.22796854999667e-29 2 1.49945702756534 1.52136716776917 1 62.7069669531493 83 280 543 388 199 300 225 155 368 2 266 261 M17624 GO_PSEUDOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOPODIUM.html A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. 19/28 Gene Ontology CC GO:0031143 0.109849236961088 0.164706433255721 445 284.727272727273 267 0.0105228284546699 35 1.04043184088943 -0.977451644245499 -1 1.30625744332807 445 267 255 183 271 530 441 171 35 223 311 262 M17146 GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX.html A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. 13/13 Gene Ontology CC GO:0043240 0.00493489397834866 0.0159754589133247 270 250.818181818182 268 0.000449636226648646 44 1.09069135910641 -1.09069135910641 -1 3.20612755435995 288 397 267 227 44 310 390 268 51 283 234 263 M17586 GO_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MEMBRANE.html The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. 205/257 Gene Ontology CC GO:0019867 0.00577426225782821 0.0159754589133247 270 282 269 0.000526315789473684 19 0.971643094848608 -0.858051622107097 -1 2.85109955345661 511 89 269 19 266 253 464 347 210 277 397 264 M17382 GO_SIN3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_COMPLEX.html A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. 17/19 Gene Ontology CC GO:0016580 0.0971661833702384 0.150945327642001 305 241.272727272727 270 0.00924939304962253 38 1.10047757863335 -0.601903742614482 -1 1.45354895239705 304 348 303 270 212 164 108 208 38 371 328 265 M17081 GO_PLATELET_ALPHA_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_MEMBRANE.html The lipid bilayer surrounding the platelet alpha granule. 15/16 Gene Ontology CC GO:0031092 0.0716154483067314 0.119909439383893 145 300.454545454545 271 0.00673261953220616 78 1.52947465538427 1.69551414396539 1 2.29213394868053 143 271 78 402 565 354 194 214 521 293 270 266 M17446 GO_VACUOLAR_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_LUMEN.html The volume enclosed within the vacuolar membrane. 116/197 Gene Ontology CC GO:0005775 0.00448660139372309 0.0159561767009529 580 256.090909090909 271 0.000408707037960626 2 1.08864991760484 -1.07814291518705 -1 3.20098737803571 580 2 81 16 38 410 547 336 271 177 359 267 M17073 GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX.html Any protein complex that is part of the plasma membrane and which functions as a receptor. 134/236 Gene Ontology CC GO:0098802 2.33633767605164e-07 5.02745255476297e-06 275 258.636363636364 273 2.12394356742193e-08 19 1.32177360814306 1.3294012791457 1 11.5792648444677 273 244 19 159 329 475 290 280 257 42 477 268 M17654 GO_WNT_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALOSOME.html A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. 18/21 Gene Ontology CC GO:1990909 0.178874493533826 0.245108680998002 210 283.181818181818 273 0.017756758302779 202 1.05068561003548 0.983587856323818 1 1.01847250104257 209 219 228 273 463 353 333 202 234 316 285 269 M17443 GO_NUCLEAR_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. 59/73 Gene Ontology CC GO:0005637 0.0110921848390329 0.0261973959003175 550 296.818181818182 274 0.00101350077484954 67 0.952786050065249 -0.892584002184791 -1 2.45512865233163 548 108 274 143 78 568 483 239 67 307 450 270 M17757 GO_NBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NBAF_COMPLEX.html A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 14/16 Gene Ontology CC GO:0071565 0.00419300569516222 0.0151312814216723 140 257.818181818182 274 0.00038191078022318 45 0.507899508313974 -0.507899508313974 -1 1.48799288923863 139 274 372 306 281 90 100 45 546 575 108 271 M17168 GO_LUMENAL_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUMENAL_SIDE_OF_MEMBRANE.html Any side (leaflet) of a membrane that faces the lumen of an organelle. 43/66 Gene Ontology CC GO:0098576 0.0939154936974322 0.146821070165513 275 347.545454545455 275 0.00892562824964229 146 0.878157551617977 -0.613215528397805 -1 1.16803447531385 275 547 260 527 211 146 188 431 563 400 275 272 M17223 GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the rough endoplasmic reticulum. 25/30 Gene Ontology CC GO:0030867 0.200154136103189 0.269188780268409 565 320.818181818182 275 0.0200985705264016 61 1.22414972492431 -0.843913028352967 -1 1.11160294538164 565 208 221 170 519 298 443 211 61 275 558 273 M17767 GO_AXONEMAL_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX.html A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 13/21 Gene Ontology CC GO:0005858 0.0173733742624669 0.0371100384062253 535 328.727272727273 275 0.00159200980447459 101 1.62131589048958 -1.63553711598865 -1 3.80343300809974 532 275 117 361 101 570 542 254 167 218 479 274 M17803 GO_FILAMENTOUS_ACTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMENTOUS_ACTIN.html A two-stranded helical polymer of the protein actin. 34/46 Gene Ontology CC GO:0031941 0.092766280793203 0.14606289740068 205 325.363636363636 275 0.0088114206237131 96 0.962126730754125 1.00317837990672 1 1.2877640361659 205 550 239 444 254 509 275 292 471 244 96 275 M17472 GO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE.html A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 140/151 Gene Ontology CC GO:0000776 0.506748803853266 0.584089241749745 275 346.818181818182 276 0.0622283393300466 124 0.972337217386268 -1.06820326254091 -1 0.330362083614536 124 526 489 571 384 225 273 276 226 450 271 276 M17775 GO_SYNAPSE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_PART.html Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 586/866 Gene Ontology CC GO:0044456 0.043945356635864 0.0802901012749591 285 280.363636363636 276 0.00448393792138491 51 1.16487625323224 1.06987333110587 1 2.07146177553549 281 71 576 51 258 239 276 423 301 66 542 277 M17682 GO_LYTIC_VACUOLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_MEMBRANE.html The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. 320/391 Gene Ontology CC GO:0098852 0.00577426225782821 0.0159754589133247 415 258.181818181818 277 0.000526315789473684 38 1.02174530470108 -0.87991424286613 -1 3.00051531785822 414 78 314 38 277 67 351 527 227 326 221 278 M17688 GO_WASH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_WASH_COMPLEX.html A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. 10/11 Gene Ontology CC GO:0071203 0.0271220226384872 0.0531370834706611 215 266.636363636364 278 0.00249657049241974 50 0.562085604463734 -0.491634816287514 -1 1.14271079787692 213 401 356 379 292 136 50 104 278 568 156 279 M17835 GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE.html A clathrin coat found on a vesicle of the trans-Golgi network. 15/16 Gene Ontology CC GO:0030130 0.00577426225782821 0.0159754589133247 485 260.818181818182 278 0.000526315789473684 20 0.944438682894039 0.937906828635797 1 2.76997003802692 278 51 223 44 106 524 360 485 20 295 483 280 M17417 GO_EXTERNAL_ENCAPSULATING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_ENCAPSULATING_STRUCTURE.html A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space. 8/13 Gene Ontology CC GO:0030312 0.00387997684210083 0.0143583856386024 455 327.727272727273 279 0.000388676793506063 36 0.758582288564989 -0.89846449116073 -1 2.27406783226716 253 453 536 454 36 279 77 271 542 533 171 281 M17764 GO_BRUSH_BORDER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER_MEMBRANE.html The portion of the plasma membrane surrounding the brush border. 60/96 Gene Ontology CC GO:0031526 0.0940059175586418 0.146821070165513 160 292.818181818182 279 0.00893462006966724 122 1.37007187923336 1.34698412792994 1 1.84840552552804 157 419 122 470 353 464 193 159 379 226 279 282 M17408 GO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE.html The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. 747/1081 Gene Ontology CC GO:0045202 0.00161808102746462 0.00764313070696705 265 314 280 0.000161926042006263 37 1.18748427694944 1.09673802429355 1 4.12592551388028 262 155 535 187 260 281 280 573 330 37 554 283 M17510 GO_POLE_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLE_PLASM.html Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. 6/18 Gene Ontology CC GO:0045495 0.120532552443186 0.17595329891832 280 300.181818181818 280 0.0127617422597743 101 1.30610041111701 1.30610041111701 1 1.58949445736763 280 144 549 201 518 359 418 183 101 284 265 284 M17100 GO_MRNA_CLEAVAGE_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_FACTOR_COMPLEX.html Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. 19/20 Gene Ontology CC GO:0005849 0.38975756390287 0.472753955381143 285 276.272727272727 281 0.0439068236395101 43 1.14742983720407 1.14742983720407 1 0.573170251144056 190 269 359 340 483 282 172 281 43 379 241 285 M17752 GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. 19/23 Gene Ontology CC GO:0033176 0.182694161952816 0.248720725751079 470 322.545454545455 281 0.0181730162357024 81 0.824014652989288 -0.546573122786149 -1 0.780017623752616 467 217 271 233 262 394 473 520 81 281 349 286 M17659 GO_CILIARY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_MEMBRANE.html The portion of the plasma membrane surrounding a cilium. 66/102 Gene Ontology CC GO:0060170 0.00577426225782821 0.0159754589133247 325 256.272727272727 284 0.000526315789473684 17 1.34217877225854 -1.19762369641091 -1 3.95611810735454 323 17 109 32 432 196 376 561 284 202 287 287 M17154 GO_ROUGH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM.html The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. 79/110 Gene Ontology CC GO:0005791 0.185832624133502 0.252263445377487 220 303.909090909091 285 0.0185163636758356 133 1.23690907187129 1.40867701238734 1 1.18158108824565 218 294 133 285 267 512 353 499 242 184 356 288 M17165 GO_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_NUCLEUS.html The nucleus of a germ cell, a reproductive cell in multicellular organisms. 20/37 Gene Ontology CC GO:0043073 0.121326977279949 0.176049434190135 185 324.090909090909 285 0.011689543614413 177 1.06505087519609 -1.26213559595387 -1 1.28713160288079 182 489 193 461 456 294 213 177 558 285 257 289 M17272 GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. 8/14 Gene Ontology CC GO:0017146 0.000324969269663504 0.00226374266737918 120 284 285 3.25016801708351e-05 10 1.22942793447325 -1.22942793447325 -1 5.35176157090141 109 511 527 424 285 171 120 10 550 300 117 290 M17445 GO_LATE_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME.html A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. 238/279 Gene Ontology CC GO:0005770 0.0103032020273395 0.0245334441716568 380 248.727272727273 285 0.000941070318612883 54 0.991965866764703 -0.865842699676237 -1 2.6049295821984 380 285 351 110 76 54 374 535 145 312 114 291 M17566 GO_GAMMA_TUBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_COMPLEX.html A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. 22/25 Gene Ontology CC GO:0000930 0.0590964894408883 0.101884452122125 250 290.181818181818 285 0.00552239374898111 112 1.29742845962043 1.21018476043937 1 2.08968131099921 373 435 248 301 176 446 191 285 112 248 377 292 M17128 GO_SITE_OF_POLARIZED_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_POLARIZED_GROWTH.html Any part of a cell where non-isotropic growth takes place. 216/272 Gene Ontology CC GO:0030427 0.0236782430056897 0.0473372498696639 415 281 287 0.00217609049699419 89 1.18384971432737 -1.28237814688678 -1 2.55688322024971 413 287 89 263 116 437 434 402 304 139 207 293 M16986 GO_ENDOLYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME.html An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. 35/66 Gene Ontology CC GO:0036019 0.00824680530818105 0.0205477894327546 255 283.272727272727 288 0.000752534733202902 60 1.20524898791331 1.04726676933198 1 3.32906554439155 314 255 112 288 482 377 283 60 316 255 374 294 M17182 GO_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON.html The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. 460/668 Gene Ontology CC GO:0030424 7.21755573822232e-06 0.000115247538866192 290 262.272727272727 288 6.56143583365256e-07 27 1.24731202388735 -1.25423090442185 -1 8.10785579881033 457 162 27 86 194 519 415 418 288 31 288 295 M17141 GO_CELL_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a cell surface projection. 333/464 Gene Ontology CC GO:0031253 2.77364667544855e-06 4.88329914677457e-05 295 243.090909090909 289 2.52150015665962e-07 24 1.3255123793049 1.38949059323953 1 9.43963502893788 292 77 24 62 457 461 289 308 200 28 476 296 M17402 GO_PRC1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRC1_COMPLEX.html A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. 12/12 Gene Ontology CC GO:0035102 0.025792762424149 0.0508406330444489 60 283.727272727273 289 0.00237274679257248 30 0.526457646336669 -0.526457646336669 -1 1.08409638865035 56 451 289 428 478 30 55 179 562 531 62 297 M17419 GO_CATION_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_COMPLEX.html An ion channel complex through which cations pass. 118/225 Gene Ontology CC GO:0034703 6.53026008634947e-09 1.80670529055669e-07 500 318.454545454545 289 5.93660009612114e-10 16 1.2566292436006 -1.34641405870078 -1 14.0193823982508 499 289 16 360 563 266 482 249 489 61 229 298 M17698 GO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS.html A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. 1482/1929 Gene Ontology CC GO:0005794 0.00525070999993344 0.0159754589133247 575 325.090909090909 289 0.000526315789473684 3 1.12872120944818 -1.10741344908195 -1 3.31954089831474 571 62 569 3 289 326 579 572 214 111 280 299 M17531 GO_LAMELLIPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM.html A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. 234/281 Gene Ontology CC GO:0030027 0.166241756540774 0.229967763214738 470 257.090909090909 290 0.0163925013226851 60 1.08854961345251 1.15315191591164 1 1.1068912124089 332 87 129 60 327 467 469 290 182 80 405 300 M17564 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. 89/112 Gene Ontology CC GO:0033116 0.00459109655292984 0.0159726173488158 415 286.818181818182 290 0.000418245965805205 10 1.19460823776243 -1.04002763311787 -1 3.51618364714846 411 10 94 133 40 450 575 422 290 179 551 301 M17259 GO_PML_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PML_BODY.html A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. 109/135 Gene Ontology CC GO:0016605 0.0131080266717474 0.0298657392011187 420 252.454545454545 291 0.0011987985983662 30 0.850336381637971 0.834841820876481 1 2.10579404676937 80 291 354 392 460 38 30 165 416 416 135 302 M17623 GO_ACROSOMAL_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_VESICLE.html A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. 80/154 Gene Ontology CC GO:0001669 0.450923709214401 0.532493241978795 295 296.545454545455 291 0.0530430307187647 126 1.2184120219385 1.31239960583415 1 0.506985262424451 277 247 126 293 350 301 291 553 289 169 366 303 M17166 GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 1096/2062 Gene Ontology CC GO:0031226 8.90808583313113e-37 2.58779893452459e-34 5 264.727272727273 292 8.90808583313112e-38 1 1.40396361311554 1.37481009944341 1 78.2295153111275 244 149 519 1 338 371 292 223 299 1 475 304 M17231 GO_PRONUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRONUCLEUS.html The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. 19/23 Gene Ontology CC GO:0045120 0.117379555000786 0.172215963271355 280 319.909090909091 292 0.0112867321890614 197 1.35755142530135 0.967219377475099 1 1.674954666767 357 493 292 484 233 340 197 244 280 322 277 305 M17573 GO_PODOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PODOSOME.html An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. 30/34 Gene Ontology CC GO:0002102 0.243658402895734 0.321010276830888 450 315 292 0.0250679169326993 222 0.948665398649169 -1.11532208167057 -1 0.730560758363623 446 339 238 396 278 292 243 343 267 222 401 306 M17731 GO_CILIARY_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PLASM.html All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. 74/119 Gene Ontology CC GO:0097014 0.202677037894989 0.271952330293276 385 320.272727272727 292 0.0203799595934886 160 1.12469780813952 -1.22715124733787 -1 1.00923091888274 381 369 222 362 548 192 444 284 292 269 160 307 M17655 GO_ACTIN_BASED_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BASED_CELL_PROJECTION.html A cell projection supported by an assembly of actin filaments, and which lacks microtubules. 227/302 Gene Ontology CC GO:0098858 0.000118095146480272 0.00110666580814578 295 275.090909090909 294 1.07364987507607e-05 40 1.25959198495034 -1.2714881239223 -1 6.13407969180219 295 238 40 59 376 482 294 490 147 60 545 308 M17052 GO_AUTOPHAGOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME.html A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. 78/88 Gene Ontology CC GO:0005776 0.116143215310638 0.171207817046787 295 281.636363636364 295 0.0111609077090295 98 0.865214191567143 -0.906555725185559 -1 1.05428514693406 191 295 413 368 297 98 264 293 371 401 107 309 M17680 GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. 179/420 Gene Ontology CC GO:0009897 1.3339515116926e-13 9.6878228536675e-12 260 285.454545454545 295 1.21268319244789e-14 5 1.47623299522927 1.53226793897841 1 26.9427767887922 256 174 5 239 467 576 389 295 373 9 357 310 M17350 GO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON.html Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. 1838/2385 Gene Ontology CC GO:0005856 0.586700258376655 0.658055695206249 580 388.090909090909 296 0.0845671067979794 226 1.03882216409146 -1.08191754591532 -1 0.266837947641381 578 226 530 256 410 288 577 565 296 252 291 311 M17462 GO_NEURON_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION.html A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 1021/1429 Gene Ontology CC GO:0043005 0.00331077669808669 0.0128237417439225 300 310.090909090909 296 0.000331571962474613 45 1.1891597280916 1.15052244512791 1 3.68817498879926 296 229 541 120 264 309 311 437 291 45 568 312 M17396 GO_SAGA_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_TYPE_COMPLEX.html A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. 31/36 Gene Ontology CC GO:0070461 0.108823067270407 0.164435233454872 235 308.545454545455 297 0.0104191851518093 169 0.865446784799755 0.898295503545188 1 1.07976314963144 231 383 439 433 227 297 257 169 178 429 351 313 M17397 GO_CELL_DIVISION_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION_SITE.html The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. 66/80 Gene Ontology CC GO:0032153 0.0194001904871312 0.0408388067863161 310 258.363636363636 297 0.00177940080592155 44 0.828335761777118 -0.946107762698693 -1 1.86324247247629 309 297 402 235 188 93 168 307 385 414 44 314 M17640 GO_ESC_E_Z_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESC_E_Z_COMPLEX.html A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. 19/20 Gene Ontology CC GO:0035098 0.576116430699151 0.648689236891874 300 300.636363636364 297 0.0750605019347898 39 1.12784127849008 -1.21988601826776 -1 0.305349309964328 371 124 296 212 398 395 507 297 39 382 286 315 M17058 GO_INTERCALATED_DISC http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCALATED_DISC.html A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. 70/108 Gene Ontology CC GO:0014704 0.0912252361690073 0.144419243090445 315 272.818181818182 298 0.00865847940381493 86 1.0484449764454 -1.20471861986396 -1 1.41602749105555 313 335 93 383 438 86 298 157 483 279 136 316 M17664 GO_CELL_PROJECTION_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_PART.html Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. 1003/1408 Gene Ontology CC GO:0044463 3.2791445373238e-05 0.000388812852282679 580 294.272727272727 299 3.27919292587877e-06 4 1.21854980250632 -1.23522422139164 -1 6.85158274250645 577 65 565 4 357 299 548 421 199 20 182 317 M16981 GO_MULTIVESICULAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY.html A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 37/51 Gene Ontology CC GO:0005771 0.0431808244157441 0.0791421419102439 300 247.636363636364 300 0.00400476442180405 79 1.16869636677245 -1.21897284678198 -1 2.09054081387807 354 300 138 141 155 330 429 399 79 99 300 318 M17176 GO_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COAT.html A membrane coat found on a coated vesicle. 51/55 Gene Ontology CC GO:0030120 0.0037729269726246 0.0141423907812574 550 286.727272727273 302 0.00034358299955761 8 0.95381029690063 -0.890020982764826 -1 2.88172308682226 546 22 277 73 33 441 520 503 8 302 429 319 M17380 GO_DNA_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR_COMPLEX.html A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 40/43 Gene Ontology CC GO:1990391 0.17520067142139 0.240642056964132 165 344.363636363636 302 0.0173580517853545 107 0.546344125431695 -0.555913150739733 -1 0.514491394054999 162 546 467 560 302 107 167 259 498 528 192 320 M17463 GO_BLOC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_COMPLEX.html Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. 20/21 Gene Ontology CC GO:0031082 0.0055796159491772 0.0159754589133247 385 255 302 0.000508528850931972 35 0.841798230671404 -0.951382406855443 -1 2.46387372665605 302 391 381 384 47 336 288 150 160 331 35 321 M17199 GO_HOPS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOPS_COMPLEX.html A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. 16/16 Gene Ontology CC GO:0030897 0.00352347180986534 0.0134934118811225 185 270.454545454545 303 0.000320829782790437 30 0.706062538842503 -0.702141703658006 -1 2.14502804060442 185 440 395 427 30 139 306 156 303 515 79 322 M17341 GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS.html A cell part consisting of multiple, closely packed actin-based cell projections. 149/238 Gene Ontology CC GO:0098862 0.108963106506241 0.164435233454872 165 276.181818181818 303 0.0104333227423663 84 1.2181419927139 1.14823867029519 1 1.53877034860929 164 325 84 312 561 370 209 385 193 132 303 323 M17403 GO_GOLGI_ASSOCIATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE.html Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. 98/113 Gene Ontology CC GO:0005798 0.00155398538092641 0.00740234405857146 530 255.818181818182 303 0.000141371285097911 8 0.997858297835922 -0.955614558650298 -1 3.48266186980616 530 8 319 149 15 270 395 357 128 303 340 324 M17112 GO_BLOC_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_1_COMPLEX.html A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. 15/16 Gene Ontology CC GO:0031083 0.00823291369875257 0.0205477894327546 305 281.181818181818 304 0.000751262324704003 66 0.871507448577902 -0.871507448577902 -1 2.3943341015843 301 444 355 431 66 304 261 151 322 356 102 325 M17612 GO_CELL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX.html The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 298/408 Gene Ontology CC GO:0005938 0.00577426225782821 0.0159754589133247 580 283.818181818182 304 0.000526315789473684 14 1.04043892672505 -1.13339045416019 -1 3.05626379347177 576 79 125 14 304 322 566 388 297 73 378 326 M17823 GO_DENSE_CORE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENSE_CORE_GRANULE.html Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. 10/17 Gene Ontology CC GO:0031045 0.0534840994351223 0.094450643683301 535 317.818181818182 306 0.00498458182058673 136 2.0351696299016 -2.0351696299016 -1 3.4155396361896 533 507 179 366 168 511 136 142 306 250 398 327 M17129 GO_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. 305/423 Gene Ontology CC GO:0030139 0.00151282598265433 0.00732459913268471 585 299.727272727273 307 0.00013762429793444 55 1.27604040776061 -1.16177547374017 -1 4.47624623866798 581 321 55 107 147 448 490 536 230 75 307 328 M17599 GO_SUPRAMOLECULAR_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPRAMOLECULAR_FIBER.html A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. 562/821 Gene Ontology CC GO:0099512 0.093374299803802 0.146622886989213 435 345.181818181818 307 0.00975467081870572 76 1.19709810570309 -1.33592330108957 -1 1.61032967189689 434 233 557 307 506 273 499 440 295 76 177 329 M17315 GO_MYELIN_SHEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_SHEATH.html An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. 237/303 Gene Ontology CC GO:0043209 0.337862307346126 0.419440172154058 230 317.727272727273 308 0.0367864714128634 226 1.07334209355251 -1.05918274144389 -1 0.625742983737558 478 286 226 229 308 234 349 445 323 229 388 330 M17831 GO_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE.html A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. 517/725 Gene Ontology CC GO:0030425 0.157757367392701 0.219900144785682 310 320.272727272727 308 0.0170221718712707 93 1.18258873763383 -1.16018261710902 -1 1.2447013699351 308 235 579 126 259 421 358 316 265 93 563 331 M16993 GO_NUCLEAR_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE.html The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). 452/592 Gene Ontology CC GO:0005635 0.318461153940136 0.401833916257997 325 317.090909090909 309 0.0342542999357014 170 0.971222222829703 -0.902471047937735 -1 0.591804176382397 325 317 450 278 299 255 309 454 170 407 224 332 M17056 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. 17/18 Gene Ontology CC GO:0012510 0.0991328581875011 0.153181357997176 550 324 309 0.00944578641058005 49 0.904688046196886 0.937906828635797 1 1.17707036755175 362 49 201 182 217 546 324 523 302 309 549 333 M17384 GO_CELL_SUBSTRATE_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION.html A cell junction that forms a connection between a cell and the extracellular matrix. 532/642 Gene Ontology CC GO:0030055 0.473192057366173 0.552057400260535 155 297.727272727273 310 0.0620812209363089 153 1.0487286011598 1.06970445370818 1 0.402616649411326 153 362 534 279 369 242 179 310 334 201 312 334 M17412 GO_CLATHRIN_COAT_OF_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_COATED_PIT.html The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. 20/22 Gene Ontology CC GO:0030132 0.0286783836331942 0.0550659441690841 395 255.909090909091 310 0.00264174477408037 24 0.806668437036931 -0.70230457019716 -1 1.63946482817753 393 44 288 117 133 425 310 397 24 330 354 335 M17632 GO_SARCOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOLEMMA.html The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. 145/199 Gene Ontology CC GO:0042383 7.33934412745115e-06 0.000115247538866192 310 294.181818181818 310 6.67215328372575e-07 28 1.19556186621017 -1.20139249251938 -1 7.76953472723262 310 243 28 332 401 210 184 540 370 65 553 336 M17169 GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. 54/63 Gene Ontology CC GO:0030660 0.0286949096481278 0.0550659441690841 395 306.909090909091 311 0.00264328742245964 110 1.04105271506481 1.04567585514583 1 2.12935144154529 359 110 301 150 134 529 393 395 155 311 539 337 M17362 GO_ENDOPLASMIC_RETICULUM_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_LUMEN.html The volume enclosed by the membranes of the endoplasmic reticulum. 194/258 Gene Ontology CC GO:0005788 1.10168111136093e-05 0.00015106719197118 170 276.454545454545 312 1.00153329838506e-06 31 1.32331163440633 1.36864005812171 1 8.34651742803677 167 322 31 274 103 492 468 352 312 48 472 338 M17207 GO_CCR4_NOT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR4_NOT_COMPLEX.html The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins. 18/18 Gene Ontology CC GO:0030014 0.0134849095313785 0.0304853402246339 375 276.909090909091 313 0.00123348015163149 89 0.724922842947569 0.837453039807925 1 1.7776196690668 206 218 374 363 89 313 316 296 150 375 346 339 M17213 GO_MYOSIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_FILAMENT.html A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. 12/29 Gene Ontology CC GO:0032982 0.220498233681154 0.294504537399426 155 339.181818181818 313 0.0223909996672943 151 1.35804093141767 1.37749596889538 1 1.15027896598143 251 571 151 541 313 474 212 220 531 152 315 340 M17237 GO_PCG_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PCG_PROTEIN_COMPLEX.html A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. 50/52 Gene Ontology CC GO:0031519 0.163963113939382 0.22735696706153 235 309.363636363636 314 0.016148424628746 141 0.693508447026482 -0.761869354435145 -1 0.694007886859657 235 337 451 381 441 186 224 234 314 459 141 341 M17792 GO_NEURONAL_CELL_BODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_CELL_BODY_MEMBRANE.html The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. 23/44 Gene Ontology CC GO:0032809 0.0151755465850534 0.0331465885936693 95 303.818181818182 314 0.00138920448597315 78 1.39830912517456 1.28717770910368 1 3.38773849787352 293 389 91 382 543 314 260 78 444 92 456 342 M17822 GO_PLATELET_DENSE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE.html Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. 22/31 Gene Ontology CC GO:0042827 0.145973186620956 0.205352109992192 535 316.454545454545 315 0.0142423935489514 87 1.20591460776331 -1.16810560884099 -1 1.32967638123795 531 304 106 315 340 328 181 189 520 87 580 343 M17317 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX.html A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. 24/31 Gene Ontology CC GO:0097526 0.0843415106288582 0.135468337568245 485 324.545454545455 316 0.00797816884763934 78 0.436481084976758 -0.484841743605291 -1 0.582471189422647 108 432 455 483 316 157 78 222 484 525 310 344 M17475 GO_CYTOPLASMIC_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_DYNEIN_COMPLEX.html Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. 23/29 Gene Ontology CC GO:0005868 0.000591120069608738 0.00353606033773571 555 315.636363636364 316 5.37526325443777e-05 9 0.79378512030808 -0.96827376277941 -1 3.18366927361785 554 122 251 289 9 541 384 245 358 403 316 345 M17066 GO_TELOMERASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_HOLOENZYME_COMPLEX.html Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. 21/23 Gene Ontology CC GO:0005697 0.0150954966538636 0.0330961643618669 420 321.636363636364 317 0.00138182561926299 95 0.632060082095965 -0.632060082095965 -1 1.50650029092946 418 215 403 253 95 417 412 221 283 504 317 346 M17360 GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX.html Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. 30/41 Gene Ontology CC GO:0005834 0.282068821682516 0.362570764153854 385 317 317 0.0296763437970848 155 1.09990326383381 -0.788028598990018 -1 0.757911980181977 317 428 224 469 382 382 155 232 325 265 308 347 M17777 GO_EARLY_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME.html A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. 351/455 Gene Ontology CC GO:0005769 0.296583522046498 0.377056950347955 320 327.363636363636 317 0.0314763485521633 76 0.969679961928247 -0.885561712682544 -1 0.635280432767725 570 76 317 102 296 247 558 522 319 347 247 348 M16997 GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the nucleus. 15/15 Gene Ontology CC GO:0000176 0.0975353278276217 0.151114734580929 290 328.545454545455 319 0.00928622637452894 117 0.593198550542442 -0.593198550542442 -1 0.761578349207343 287 272 376 319 214 180 117 473 464 498 414 349 M17088 GO_SECRETORY_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_LUMEN.html The volume enclosed by the membrane of a secretory granule. 65/169 Gene Ontology CC GO:0034774 0.000115712866369412 0.00110211762886276 170 293.909090909091 319 1.05199048126517e-05 39 1.39341573066854 1.39646370490941 1 6.79487009475073 168 372 39 501 96 386 205 579 506 62 319 350 M17045 GO_SECRETORY_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE.html A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. 326/584 Gene Ontology CC GO:0030141 1.98061666412296e-06 3.59605713079825e-05 185 282.909090909091 320 1.80056222475943e-07 23 1.25002119020282 1.20476621752128 1 9.17511349551379 184 320 23 395 218 337 203 494 425 58 455 351 M17113 GO_T_CELL_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_COMPLEX.html A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. 10/24 Gene Ontology CC GO:0042101 0.108329957635228 0.164333434428374 360 298.818181818182 321 0.0103694195880089 89 1.078534295654 -1.03796640034424 -1 1.35756257665737 356 138 118 243 469 428 89 433 321 126 566 352 M17547 GO_CELL_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION.html A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. 434/593 Gene Ontology CC GO:0005911 6.03634183006704e-05 0.000649465667272028 325 317 321 5.48773405552552e-06 36 1.14164524873887 -1.20337807029703 -1 5.99397288317151 321 163 36 238 513 454 246 500 372 63 581 353 M17796 GO_PHOTORECEPTOR_OUTER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT.html The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes. 72/111 Gene Ontology CC GO:0001750 0.173036213326563 0.238232322139178 330 276.818181818182 321 0.0171239061782504 95 1.24170518185511 1.29785738691834 1 1.23757142292236 328 105 95 100 458 406 367 321 318 158 389 354 M17782 GO_PHOTORECEPTOR_DISC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_DISC_MEMBRANE.html Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment. 19/33 Gene Ontology CC GO:0097381 0.00107570913916182 0.00553085849427451 325 337.272727272727 323 9.78395888035703e-05 22 1.33869515112841 1.53398064079713 1 4.96940862919114 436 309 192 215 523 463 413 22 491 323 323 355 M17149 GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX.html A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. 14/15 Gene Ontology CC GO:0005847 0.569330021406025 0.643542300460896 315 345.636363636364 324 0.0737239860729857 22 1.31687867127606 1.31687867127606 1 0.371894241007528 311 314 324 303 502 485 472 442 22 351 276 356 M17581 GO_DESMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DESMOSOME.html A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. 30/36 Gene Ontology CC GO:0030057 0.14821160119421 0.207496241671894 150 299 324 0.0144775540792604 124 1.32003259038196 -1.61465108189608 -1 1.45002684245913 186 379 149 446 324 341 274 383 536 147 124 357 M17150 GO_NEURON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PART.html Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 1276/1803 Gene Ontology CC GO:0097458 0.000206662134867568 0.00162257703186564 350 299.363636363636 325 2.06681356540559e-05 7 1.20316123745846 1.16190777087349 1 5.52526744314841 348 227 517 7 286 347 325 457 255 27 497 358 M17605 GO_MICROTUBULE_ASSOCIATED_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ASSOCIATED_COMPLEX.html Any multimeric complex connected to a microtubule. 143/174 Gene Ontology CC GO:0005875 0.16963466761452 0.234103899962081 365 301.272727272727 326 0.016757058919512 93 1.0440893499436 -1.05697834821861 -1 1.04636283677409 365 326 259 193 542 286 352 413 93 340 145 359 M16976 GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. 117/187 Gene Ontology CC GO:0000784 0.334422606799154 0.416442774096374 240 347.181818181818 327 0.0363326563678658 139 1.00791133406228 -1.18339852762721 -1 0.589971139602061 236 462 428 533 510 237 327 303 139 427 217 360 M17643 GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX.html Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. 134/172 Gene Ontology CC GO:0031461 0.0128215009292803 0.0294438420549875 140 253.727272727273 328 0.00117243995256593 19 0.837970124114863 -0.810949991889513 -1 2.08308767458822 137 328 426 356 341 19 159 236 402 333 54 361 M17565 GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. 105/135 Gene Ontology CC GO:0031234 0.346617125443823 0.427774993031891 370 294.363636363636 329 0.0379512759513732 3 1.11858945388274 1.01017420522998 1 0.638216726344903 367 3 143 94 578 436 329 466 216 104 502 362 M17442 GO_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COMPLEX.html A protein complex which is capable of ATPase activity. 24/33 Gene Ontology CC GO:1904949 0.00683104999981843 0.0178350501723984 335 296.818181818182 330 0.000622941202622686 56 1.28843830408 -1.22402727553466 -1 3.69357401774713 335 431 123 456 462 230 330 56 449 266 127 363 M17786 GO_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME.html A vacuole to which materials ingested by endocytosis are delivered. 860/1101 Gene Ontology CC GO:0005768 0.00525070999993344 0.0159754589133247 555 336.454545454545 330 0.000526315789473684 15 1.03843255834436 -0.995401965542823 -1 3.05028036347627 552 68 577 15 330 365 545 506 237 242 264 364 M17062 GO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CENTROMERIC_REGION.html The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 202/318 Gene Ontology CC GO:0000775 0.644678164162229 0.690946349517695 525 351 331 0.0897777546868929 161 0.930785888802049 -1.00736076469349 -1 0.201518290243301 161 523 498 522 388 223 258 331 203 452 302 365 M17413 GO_SIN3_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_TYPE_COMPLEX.html Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. 20/22 Gene Ontology CC GO:0070822 0.394013321062113 0.476000159926977 420 313.363636363636 331 0.0445149062731139 47 1.10047757863335 -0.601903742614482 -1 0.542382476648157 420 484 331 272 411 221 154 294 47 386 427 366 M17561 GO_ANCHORING_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORING_JUNCTION.html A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. 638/772 Gene Ontology CC GO:0070161 0.570723938969973 0.643865259303989 185 337.363636363636 331 0.0810885415536926 180 1.06634921886283 1.05582055152077 1 0.291901092533823 181 281 554 331 511 308 204 375 377 180 409 367 M17762 GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 145/190 Gene Ontology CC GO:0019897 0.463786646509038 0.543266212947079 335 315.727272727273 331 0.0550815485363 118 1.11035318407456 1.09876176323158 1 0.441860048103835 331 180 157 165 568 435 362 441 236 118 480 368 M17785 GO_TRANS_GOLGI_NETWORK_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_MEMBRANE.html The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. 82/97 Gene Ontology CC GO:0032588 0.0397984651111024 0.0738751061646981 155 316.363636363636 332 0.00368520059015719 104 0.84436579790048 -0.824591792627793 -1 1.53938774124044 569 104 370 151 151 381 556 332 175 410 281 369 M17015 GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK.html A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. 15/15 Gene Ontology CC GO:0071782 0.046675425662527 0.0840421367346448 270 315.363636363636 334 0.00433601328974611 49 0.624592667885626 -0.645260328577248 -1 1.06853596100764 496 270 334 112 158 481 565 381 49 355 268 370 M17622 GO_ENDOSOMAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOMAL_PART.html Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. 481/614 Gene Ontology CC GO:0044440 0.00577426225782821 0.0159754589133247 540 320.545454545455 334 0.000526315789473684 33 1.01229067497059 -0.966510102380999 -1 2.97231954101574 538 160 404 33 210 334 581 550 189 348 179 371 M17503 GO_SPERM_MIDPIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MIDPIECE.html The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. 12/16 Gene Ontology CC GO:0097225 0.0540561502539102 0.0951715857500661 440 301.727272727273 335 0.00503926618387807 30 1.09325942596048 -1.60531566348459 -1 1.8072327389639 439 449 249 300 400 275 335 432 30 339 71 372 M17078 GO_COPI_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_VESICLE_COAT.html One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. 13/13 Gene Ontology CC GO:0030126 0.00734570426406008 0.0188843105195527 340 296.727272727273 336 0.000670031501758905 1 1.13207750296915 -1.46891565428805 -1 3.19302905431966 500 313 284 76 62 447 563 337 1 345 336 373 M17804 GO_METHYLOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLOSOME.html A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. 12/17 Gene Ontology CC GO:0034709 0.0386066689586321 0.0723563698869847 380 306.454545454545 336 0.00357284399136417 53 0.443625475846795 -0.463005155054028 -1 0.793335545010688 113 277 377 380 336 202 53 273 410 578 372 374 M17038 GO_CATION_TRANSPORTING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_COMPLEX.html Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 14/21 Gene Ontology CC GO:0090533 0.00435732235536059 0.0156271869658303 525 305.545454545455 337 0.000396906952611131 47 1.44769877944234 -1.42122752962379 -1 4.29380603211675 522 353 98 451 335 412 485 47 149 172 337 375 M17308 GO_NUCLEAR_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. 275/368 Gene Ontology CC GO:0000790 0.107005198276744 0.162748743975886 365 314.181818181818 337 0.0102358461414473 104 1.06254949605028 -1.13219622444302 -1 1.34417497452869 240 459 390 418 365 163 331 287 337 362 104 376 M17202 GO_ORGANELLE_MEMBRANE_CONTACT_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_CONTACT_SITE.html A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. 12/13 Gene Ontology CC GO:0044232 0.68618940391 0.690946349517695 515 360.454545454545 338 0.1 126 0.690770647449964 0.762204207372449 1 0.137549886141321 514 223 312 232 426 569 286 393 126 338 546 377 M17737 GO_COHESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_COHESIN_COMPLEX.html A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). 10/14 Gene Ontology CC GO:0008278 0.0778888041885398 0.12747435277054 220 334.636363636364 338 0.00734466423341914 144 0.527362018275256 0.527362018275256 1 0.7365659089331 200 357 329 408 404 218 219 144 492 572 338 378 M17307 GO_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION.html A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. 1230/1673 Gene Ontology CC GO:0030054 0.00274722920066802 0.0110078632109526 245 317 339 0.000275063139240098 44 1.14027703700156 1.07835815624126 1 3.66016862630971 241 148 528 186 443 339 208 481 346 44 523 379 M17639 GO_CONDENSED_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. 215/358 Gene Ontology CC GO:0000793 0.68618940391 0.690946349517695 340 377.818181818182 339 0.1 178 1.05558537078418 -1.24527659007342 -1 0.23477961002524 178 522 480 515 412 303 308 339 327 433 339 380 M17839 GO_PRIMARY_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_LYSOSOME.html A lysosome before it has fused with a vesicle or vacuole. 18/68 Gene Ontology CC GO:0005766 0.0329703101646398 0.0623965804744487 355 306.545454545455 339 0.00304318563704277 114 1.15591519091857 1.08365938331677 1 2.26527811646582 433 392 170 339 163 284 354 114 453 317 353 381 M17383 GO_ESCRT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_COMPLEX.html An endosomal sorting complex required for transport. 28/28 Gene Ontology CC GO:0036452 0.0220578338247858 0.0446536635965176 470 346.636363636364 341 0.00202564973187155 111 0.603542863653269 -0.575714400059516 -1 1.30610778537439 466 341 452 271 111 262 525 258 399 529 199 382 M17841 GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT.html A distinct region of the endoplasmic reticulum 21/22 Gene Ontology CC GO:0098827 0.0882803551665298 0.141237851995155 345 329.454545454545 341 0.0083668688389235 128 0.61767201064896 -0.630053744860258 -1 0.825018206095576 521 344 341 267 202 442 509 255 224 391 128 383 M17358 GO_SPECIFIC_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFIC_GRANULE.html Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. 22/29 Gene Ontology CC GO:0042581 0.284115964469181 0.364395972089612 495 336.090909090909 342 0.0299282000905558 83 1.22880634618077 1.13394441744904 1 0.847742857932729 491 342 210 255 290 423 373 427 83 246 557 384 M17435 GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX.html A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. 9/10 Gene Ontology CC GO:0031414 0.0737659743762847 0.122802381411523 540 333.636363636364 344 0.00763355021080618 72 0.582291505116195 0.576461305695851 1 0.833808990225535 315 142 538 249 198 409 344 391 72 538 474 385 M16985 GO_PHAGOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. 134/188 Gene Ontology CC GO:0045335 0.262942277644653 0.342532428949649 345 334 345 0.0273542759402982 137 1.12424401034536 -0.958495048110704 -1 0.821793579896 342 527 189 440 371 137 345 453 388 296 186 386 M17388 GO_U5_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U5_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U5. 16/20 Gene Ontology CC GO:0005682 0.104767397907528 0.160644719906511 280 347.272727272727 345 0.0100106207960821 86 0.462808463067088 -0.465719308073561 -1 0.563539772222663 279 443 432 345 520 200 86 250 408 530 327 387 M17464 GO_BETA_CATENIN_DESTRUCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX.html A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. 17/18 Gene Ontology CC GO:0030877 0.135627036903125 0.192659933658677 565 333.727272727273 346 0.0131626888776767 87 0.483660306310809 0.483660306310809 1 0.527661583261424 87 563 346 563 493 96 97 191 509 541 185 388 M17528 GO_SCHMIDT_LANTERMAN_INCISURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHMIDT_LANTERMAN_INCISURE.html Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. 18/21 Gene Ontology CC GO:0043220 0.344260092655213 0.426471458065414 545 384.454545454545 346 0.0376362900046849 256 0.894395688907837 -1.15719437313043 -1 0.502939284038462 542 346 270 342 309 565 357 256 286 377 579 389 M17548 GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 17/20 Gene Ontology CC GO:0000780 0.00656377295584592 0.0173660967836959 350 312.454545454545 347 0.000598494398248798 21 0.570669262805149 0.570669262805149 1 1.62096935584308 118 349 322 422 301 131 21 384 490 552 347 390 M17710 GO_MICROTUBULE_ORGANIZING_CENTER_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_PART.html Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. 163/194 Gene Ontology CC GO:0044450 0.232246540836556 0.306671000513725 345 355.727272727273 348 0.0237397278412369 174 0.893188711663732 -0.954363100836017 -1 0.714541571136647 341 409 430 323 496 254 340 348 353 445 174 391 M16990 GO_CONDENSED_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. 89/221 Gene Ontology CC GO:0000794 0.68618940391 0.690946349517695 250 366.181818181818 349 0.1 247 1.06228868228673 -1.34804653878469 -1 0.236566163814913 247 465 333 459 437 307 342 349 404 363 322 392 M17008 GO_CELL_CELL_CONTACT_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_CONTACT_ZONE.html Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. 83/126 Gene Ontology CC GO:0044291 0.135175088837286 0.192491976996233 565 383.727272727273 350 0.0131157927439175 88 1.03666719691839 -1.14904783749235 -1 1.18485810033148 563 246 88 299 574 269 550 558 473 251 350 393 M17197 GO_TRANS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. 208/247 Gene Ontology CC GO:0005802 0.0781895738132797 0.127607141532347 545 342.272727272727 351 0.00737410308559579 88 0.909036743035016 -0.839607757578157 -1 1.3026606542116 545 88 349 139 195 351 578 493 235 390 402 394 M17518 GO_CLATHRIN_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated vesicle. 80/104 Gene Ontology CC GO:0030665 0.00577426225782821 0.0159754589133247 440 267.545454545455 351 0.000526315789473684 12 1.09013714450962 1.20437665569904 1 3.20447476503458 437 12 115 42 92 451 369 363 351 191 520 395 M17810 GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the plasma membrane. 405/687 Gene Ontology CC GO:0098797 5.23074459098762e-12 2.17075900525986e-10 320 338.818181818182 351 4.75522235545459e-13 9 1.27433504787938 -1.25906358884152 -1 20.3950100874831 560 318 9 351 427 318 544 411 411 43 335 396 M17354 GO_NUCLEAR_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EUCHROMATIN.html The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. 33/47 Gene Ontology CC GO:0005719 0.000606079637181041 0.00355689160810288 195 295 352 5.5113333721602e-05 5 1.29844922987513 -1.44819080161301 -1 5.23184668652874 193 378 185 453 352 439 567 40 429 204 5 397 M17620 GO_INTERMEDIATE_FILAMENT_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_CYTOSKELETON.html Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. 153/303 Gene Ontology CC GO:0045111 0.0180159620379714 0.0383416627987596 415 293.636363636364 352 0.00165138272644392 39 1.441022203472 -1.7938592873912 -1 3.34138830504945 368 241 82 352 413 399 533 279 414 110 39 398 M17795 GO_HISTONE_DEACETYLASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_COMPLEX.html A protein complex that possesses histone deacetylase activity. 63/70 Gene Ontology CC GO:0000118 0.0275955538844396 0.0536221297888275 170 327.636363636364 352 0.0025407181925836 105 0.853883833250819 -0.722684493352786 -1 1.75450543533713 246 471 462 538 516 155 169 105 352 423 167 399 M17132 GO_MITOTIC_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE.html A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. 71/75 Gene Ontology CC GO:0072686 0.435751408182164 0.519859482862089 225 345.727272727273 353 0.050693602552542 174 0.920128746775331 -0.864793103020783 -1 0.387399634284686 223 416 391 512 475 174 247 389 333 353 290 400 M17284 GO_ACTOMYOSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN.html Any complex of actin, myosin, and accessory proteins. 93/116 Gene Ontology CC GO:0042641 0.0280428023138233 0.0543095604811044 535 349.818181818182 353 0.00258243347531967 130 0.921074977400215 0.795343070778534 1 1.88777011253245 535 332 202 367 130 259 538 353 445 308 379 401 M17431 GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of an organellar ribosome. 24/29 Gene Ontology CC GO:0000314 0.146472328017558 0.205556576275849 390 312.454545454545 354 0.0142947831315767 62 0.634894686437846 -0.470513623305824 -1 0.677554181243691 62 386 444 430 247 154 104 354 389 537 330 402 M17137 GO_MALE_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GERM_CELL_NUCLEUS.html The nucleus of a male germ cell, a reproductive cell in males. 18/33 Gene Ontology CC GO:0001673 0.521997262449 0.598186211997769 310 389.090909090909 355 0.0649016135106693 212 1.0147070980503 -1.24392420763013 -1 0.329340756221589 307 497 212 517 346 470 382 306 574 314 355 403 M17744 GO_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_COMPLEX.html An ion channel complex through which calcium ions pass. 56/87 Gene Ontology CC GO:0034704 0.135030589591624 0.192491976996233 210 350.181818181818 356 0.0131008035623066 87 0.948835085318402 1.0621912768317 1 1.08052622168116 208 420 87 474 562 452 356 269 545 234 245 404 M16980 GO_AGGRESOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGGRESOME.html An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. 38/47 Gene Ontology CC GO:0016235 0.116166474547194 0.171207817046787 340 385.727272727273 357 0.0111632733655764 214 0.750717202830544 -0.646681239054954 -1 0.908607171659176 339 474 335 506 230 357 214 302 540 417 529 405 M17119 GO_SECRETORY_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_VESICLE.html A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. 434/739 Gene Ontology CC GO:0099503 1.85652664912769e-06 3.47949026820383e-05 370 315.363636363636 359 1.68775292346123e-07 22 1.23988555449555 1.19434875453465 1 9.12979527763174 366 282 22 359 162 493 321 464 403 56 541 406 M17711 GO_NUCLEAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE.html Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. 311/392 Gene Ontology CC GO:0031965 0.566424335062263 0.641505923335623 420 342.545454545455 359 0.0731575855497351 174 0.979089263565461 -0.892271362024093 -1 0.266796395594215 417 284 347 240 359 398 419 491 174 366 273 407 M17630 GO_INTEGRATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRATOR_COMPLEX.html A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. 14/14 Gene Ontology CC GO:0032039 0.0228234787534873 0.0458838794317514 350 337.727272727273 360 0.00209670487756332 114 0.593709283618598 -0.610096708806143 -1 1.27243637904762 350 395 360 403 114 217 431 175 446 563 261 408 M17070 GO_SARCOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the sarcoplasmic reticulum. 31/45 Gene Ontology CC GO:0033017 0.68618940391 0.690946349517695 470 360.818181818182 361 0.1 146 0.916055474819558 -0.802058632973073 -1 0.197592368418865 470 204 146 313 375 498 531 351 530 190 361 409 M17329 GO_ARP2_3_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_PROTEIN_COMPLEX.html A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. 10/11 Gene Ontology CC GO:0005885 0.00653051452548657 0.0173660967836959 455 355.454545454545 361 0.000595452795716396 55 0.496520225396349 -0.631782183448466 -1 1.40430239170464 453 452 361 343 55 420 307 230 275 526 488 410 M17497 GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX.html A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. 19/24 Gene Ontology CC GO:0046540 0.196492458292483 0.264877304565969 180 342.636363636364 363 0.0196916013702547 116 0.415902732333119 -0.482784928284914 -1 0.351769606829979 179 488 438 481 363 173 116 228 426 545 332 411 M17611 GO_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUCHROMATIN.html A dispersed and relatively uncompacted form of chromatin. 41/56 Gene Ontology CC GO:0000791 0.00046490222383026 0.00300120213383757 185 289 363 4.22727723334096e-05 4 1.24818467262162 -1.44819080161301 -1 5.18037250457974 183 427 227 458 380 363 410 35 438 254 4 412 M17619 GO_CYTOPLASMIC_VESICLE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_VESICLE_PART.html Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. 589/882 Gene Ontology CC GO:0044433 0.0143201461089156 0.0317557438522136 540 346.727272727273 363 0.00144132717855216 57 1.20390966727198 -1.16177665704 -1 2.94749165554504 537 158 559 260 131 431 537 446 335 57 363 413 M17306 GO_PLATELET_DENSE_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_TUBULAR_NETWORK.html A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. 13/14 Gene Ontology CC GO:0031094 0.0143765031989383 0.0317594994622933 495 348.818181818182 364 0.00131557445298824 76 1.05195842874831 -0.970416901858392 -1 2.56950917392773 493 315 169 401 331 566 439 76 364 164 519 414 M17832 GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the nucleus. 43/47 Gene Ontology CC GO:0000152 0.0215571165393347 0.0442568364288107 50 269.818181818182 365 0.00197920835864695 37 0.606195834278084 -0.575580110075147 -1 1.31595465745151 49 374 431 365 558 37 49 91 466 425 123 415 M17801 GO_PLASMA_MEMBRANE_RAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RAFT.html A membrane raft that is part of the plasma membrane. 114/155 Gene Ontology CC GO:0044853 0.0287176954960972 0.0550659441690841 550 333.454545454545 366 0.00264541444450646 66 1.20452906563294 -1.12590596302959 -1 2.47103338548529 547 366 66 338 284 396 457 212 448 138 416 416 M17218 GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT.html The small subunit of a ribosome located in the cytosol. 47/76 Gene Ontology CC GO:0022627 0.12148673610052 0.176049434190135 110 350.727272727273 367 0.0117058806837698 95 0.949566737026796 -1.17274532220681 -1 1.14251934141486 110 548 424 526 347 212 95 317 478 434 367 417 M17028 GO_NUCLEOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOID.html The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. 64/68 Gene Ontology CC GO:0009295 0.0084112579636471 0.0207073765969448 430 284.727272727273 370 0.000767599082904337 62 0.81453001418516 -0.807178463123121 -1 2.23021071267225 106 470 434 429 370 121 84 62 537 428 91 418 M17344 GO_PHAGOCYTIC_CUP http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_CUP.html An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. 34/43 Gene Ontology CC GO:0001891 0.109993280728433 0.164706433255721 555 336.454545454545 370 0.010537385590795 35 0.947891617991755 0.907407645708789 1 1.18593300304264 551 35 197 180 224 415 532 474 480 243 370 419 M17364 GO_LATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_PLASMA_MEMBRANE.html The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. 69/93 Gene Ontology CC GO:0016328 0.68618940391 0.690946349517695 360 383.545454545455 370 0.1 165 1.01737819725338 -0.867571258802302 -1 0.224596707046894 358 370 165 420 573 320 522 334 472 192 493 420 M16998 GO_ER_TO_GOLGI_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE.html A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. 97/130 Gene Ontology CC GO:0030134 0.00240316410253186 0.00997313102550724 450 325.545454545455 371 0.000218708473994601 22 1.07228724456837 -0.933502202087731 -1 3.51546272784096 424 331 162 371 22 287 380 449 447 321 387 421 M17499 GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 113/125 Gene Ontology CC GO:0000779 0.68618940391 0.690946349517695 175 382.727272727273 371 0.1 171 1.01693036038861 -1.16376578680738 -1 0.224477350420306 171 532 476 520 394 332 347 371 287 420 360 422 M17675 GO_A_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_A_BAND.html The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. 45/72 Gene Ontology CC GO:0031672 0.105873022174149 0.161449411766878 410 364.727272727273 372 0.0101218332556751 222 0.932790796149756 -0.840995699928344 -1 1.17972935547175 449 543 281 387 222 296 409 323 324 372 406 423 M17156 GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. 12/15 Gene Ontology CC GO:0016471 0.365238908044631 0.444871709798597 540 373.090909090909 374 0.040476795969194 60 0.923688421600763 1.03876502002039 1 0.49280786773351 374 502 264 385 536 563 536 312 60 337 235 424 M17221 GO_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIGASE_COMPLEX.html A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. 256/305 Gene Ontology CC GO:0000151 0.0303064175383645 0.0579211466769401 270 339.909090909091 374 0.00279383103874939 42 0.811447703961065 -0.765337609153678 -1 1.61988226451197 270 518 494 416 374 42 319 333 463 458 52 425 M17724 GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX.html Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. 47/50 Gene Ontology CC GO:0008023 0.497259052375115 0.574368806023742 435 341.454545454545 374 0.0606023311548093 125 0.75712862678525 0.740711081007891 1 0.256099116432381 268 299 454 404 477 374 175 311 125 435 434 426 M17009 GO_MUSCLE_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_MYOSIN_COMPLEX.html A filament of myosin found in a muscle cell of any type. 11/27 Gene Ontology CC GO:0005859 0.443169660082651 0.527626173172173 560 371 375 0.0518350455136873 186 1.06718359080943 -1.26340329228576 -1 0.445344807400789 559 450 186 375 378 369 394 263 556 262 289 427 M17338 GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX.html A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. 15/19 Gene Ontology CC GO:0033276 0.329510259924499 0.41213042656722 530 409.727272727273 376 0.0356882314492056 89 0.822870948844025 -0.799749347308887 -1 0.479287929710024 553 352 366 324 305 528 516 376 89 527 571 428 M17399 GO_NUCLEAR_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_HETEROCHROMATIN.html A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. 37/40 Gene Ontology CC GO:0005720 0.446456979246414 0.530375855089266 485 374.181818181818 376 0.0523452901339422 216 1.38606726333482 -1.55443565879128 -1 0.587134180680782 482 376 216 369 440 486 411 456 357 273 250 429 M17021 GO_SPERM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PART.html Any constituent part of a sperm, a mature male germ cell that develops from a spermatid. 128/232 Gene Ontology CC GO:0097223 0.287308793269599 0.366940443410081 405 325.454545454545 379 0.0303223180172224 95 1.19270761738557 -1.21912317060426 -1 0.815487895648322 401 183 121 280 470 427 379 555 162 95 507 430 M17418 GO_CELL_TRAILING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_TRAILING_EDGE.html The area of a motile cell opposite to the direction of movement. 14/27 Gene Ontology CC GO:0031254 0.117829353807239 0.172440439702786 490 380.363636363636 379 0.0113325487635027 109 0.671157144832515 -0.762748766552107 -1 0.80390948557687 489 312 253 414 356 289 474 379 575 534 109 431 M17709 GO_MYOSIN_II_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_II_COMPLEX.html A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. 15/31 Gene Ontology CC GO:0016460 0.0122296371667349 0.0283084430034781 575 356.818181818182 379 0.00111801405893793 72 1.03830483641703 -1.12271838386223 -1 2.62165968365619 575 442 198 316 379 295 504 72 496 236 412 432 M17679 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE.html A cellular membrane associated with the pre-autophagosomal structure. 18/18 Gene Ontology CC GO:0034045 0.259503615337482 0.338812585418151 420 376.818181818182 380 0.0269426234015284 127 0.522813575142692 0.460728381368873 1 0.361374660487572 419 127 380 213 283 499 277 531 274 567 575 433 M17800 GO_SITE_OF_DOUBLE_STRAND_BREAK http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_DOUBLE_STRAND_BREAK.html A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. 35/46 Gene Ontology CC GO:0035861 0.281623991652256 0.362570764153854 355 398.909090909091 381 0.0296217035145269 193 0.883110639309707 -1.07858580261477 -1 0.599350697878878 355 477 393 557 501 260 372 534 381 365 193 434 M17007 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE.html A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. 32/33 Gene Ontology CC GO:0000407 0.056394795604968 0.0980999288816959 490 353.454545454545 383 0.00526313871323995 127 0.667573470461235 -0.783440055404977 -1 1.07083335656069 486 203 383 291 173 489 571 408 127 432 325 435 M17311 GO_EARLY_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding an early endosome. 144/194 Gene Ontology CC GO:0031901 0.0559920221288112 0.0979860387254197 510 383.727272727273 383 0.00522454631081784 170 1.01026376356044 -0.864169998808298 -1 1.64527536720183 507 364 307 329 170 581 417 426 396 341 383 436 M17467 GO_CATALYTIC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_COMPLEX.html A protein complex which is capable of catalytic activity. 1033/1220 Gene Ontology CC GO:1902494 0.470134187327726 0.549593486594384 545 384.909090909091 383 0.0615382204388696 191 0.808907939472928 -0.764012976966252 -1 0.302510182935789 383 405 542 398 445 191 371 315 344 542 298 437 M17703 GO_TELOMERE_CAP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAP_COMPLEX.html A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. 14/14 Gene Ontology CC GO:0000782 0.68618940391 0.690946349517695 475 401.454545454545 384 0.1 326 0.751239084131192 -0.844298992067427 -1 0.153665818493157 475 396 326 374 402 561 408 360 378 352 384 438 M16978 GO_CLATHRIN_SCULPTED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_SCULPTED_VESICLE.html A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. 17/26 Gene Ontology CC GO:0060198 0.287362997851268 0.366940443410081 215 366.545454545455 385 0.0303290227940385 130 0.792527496168739 0.564774351930171 1 0.526253870033645 214 495 187 488 540 142 130 504 579 368 385 439 M17001 GO_CENTRIOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE.html A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. 111/137 Gene Ontology CC GO:0005814 0.13412994613779 0.191944578093734 355 364.545454545455 386 0.0130074293830874 129 0.84433325130735 -0.97116071017537 -1 0.958126557296878 352 367 386 336 555 426 440 185 393 441 129 440 M17437 GO_CONNEXON_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNEXON_COMPLEX.html An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. 7/20 Gene Ontology CC GO:0005922 0.0831032228580624 0.134492959555806 405 350.636363636364 386 0.00863850968204087 82 1.4793296626957 -1.49316833093115 -1 2.09305367804819 334 404 539 449 207 277 403 329 386 82 447 441 M17734 GO_ESCRT_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_III_COMPLEX.html An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. 12/12 Gene Ontology CC GO:0000815 0.230180828533892 0.305331190361167 390 358.909090909091 386 0.0235012267181697 173 0.63430250464496 -0.63430250464496 -1 0.495944360785653 386 398 407 344 334 391 456 248 240 571 173 442 M16994 GO_RETROMER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROMER_COMPLEX.html A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. 23/25 Gene Ontology CC GO:0030904 0.0219563384497265 0.0446036106268919 95 294.272727272727 387 0.00201623432075533 81 0.51249896895123 0.569269679875179 1 1.10247450796313 92 387 433 460 415 208 81 93 461 497 110 443 M17502 GO_STAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAGA_COMPLEX.html A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. 15/17 Gene Ontology CC GO:0030914 0.121787735801884 0.176049434190135 475 375.818181818182 387 0.0117366685019775 164 0.894226366905197 -0.603419590469004 -1 1.07322068100563 472 351 387 457 236 523 445 210 164 357 532 444 M16987 GO_90S_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_90S_PRERIBOSOME.html A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 24/28 Gene Ontology CC GO:0030686 0.101843076278514 0.156951796598983 190 363.909090909091 388 0.00971707009722116 189 0.41023641747437 -0.405867768148953 -1 0.501115207821067 189 388 466 465 219 267 240 309 525 495 440 445 M17546 GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX.html RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 20/22 Gene Ontology CC GO:0005665 0.45855057564208 0.538217948379896 300 397.454545454545 388 0.0542464272849282 287 0.67354378608334 -0.577490719893951 -1 0.254253133226338 300 560 409 535 337 321 287 368 430 388 437 446 M17348 GO_CYTOSKELETAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PART.html Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. 1329/1737 Gene Ontology CC GO:0044430 0.225291194638606 0.300216018543647 410 355.545454545455 389 0.0252037513099267 147 1.04984282703033 -1.11953075582056 -1 0.864128668386925 408 359 529 389 484 147 421 451 269 278 176 447 M17708 GO_BAF_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BAF_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family. 20/23 Gene Ontology CC GO:0090544 0.68618940391 0.690946349517695 485 362.727272727273 389 0.1 99 0.81129164162613 -0.507899508313974 -1 0.169670911517889 485 436 343 254 481 319 300 400 99 389 484 448 M17206 GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX.html A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. 17/18 Gene Ontology CC GO:0005852 0.400518222430428 0.482782338655764 445 377.272727272727 390 0.04545190127668 142 0.584083884325302 0.584083884325302 1 0.260070139162779 142 441 441 513 328 238 320 390 500 516 321 449 M17273 GO_BLOOD_MICROPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_MICROPARTICLE.html A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. 140/447 Gene Ontology CC GO:0072562 3.10659708976967e-09 9.49964689029568e-08 330 320.181818181818 390 2.82417917650588e-10 14 1.47326359481345 1.38752166396331 1 17.1270102476569 421 327 14 330 73 520 437 564 390 18 428 450 M17313 GO_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 264/357 Gene Ontology CC GO:0005667 0.225951692363356 0.300407169938466 410 337.909090909091 390 0.023014752414526 202 0.923524366516697 0.989809859514454 1 0.754130482986769 237 407 414 390 275 264 202 278 407 402 441 451 M17656 GO_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION.html A prolongation or process extending from a cell, e.g. a flagellum or axon. 1802/2503 Gene Ontology CC GO:0042995 1.1180532280139e-05 0.00015106719197118 415 335.636363636364 391 1.11805885324733e-06 17 1.16997104511966 -1.17857401817059 -1 7.37395863678039 415 145 564 45 358 531 391 559 207 17 460 452 M17683 GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. 49/80 Gene Ontology CC GO:0031463 0.258180332497289 0.337844083740821 445 372.363636363636 391 0.0267846721794992 134 0.939012014571783 -0.89394873993783 -1 0.688053213227868 444 541 275 496 391 134 361 574 441 231 208 453 M17610 GO_PHOTORECEPTOR_INNER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_INNER_SEGMENT.html The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. 35/55 Gene Ontology CC GO:0001917 0.492423621365466 0.569916581699872 380 384.181818181818 392 0.0597845135223937 128 1.34993128420446 -1.02450186642062 -1 0.500637167893858 463 475 128 378 534 338 487 392 435 216 380 454 M17296 GO_COSTAMERE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COSTAMERE.html Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. 28/29 Gene Ontology CC GO:0043034 0.43119990772354 0.51655081729356 475 315.909090909091 393 0.05 37 0.951861258921204 -1.18597554248154 -1 0.40674676059497 471 37 195 145 439 393 541 412 124 207 511 455 M17532 GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 124/154 Gene Ontology CC GO:0044798 0.68618940391 0.690946349517695 405 392.454545454545 393 0.1 287 0.883384910713698 -0.755161508067474 -1 0.188885072018894 402 329 440 287 393 483 343 369 339 396 536 456 M17415 GO_SMALL_SUBUNIT_PROCESSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_SUBUNIT_PROCESSOME.html A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 32/36 Gene Ontology CC GO:0032040 0.077038850467265 0.126797654735074 545 365.363636363636 394 0.00726151928075858 89 0.500030251036125 0.513420393673369 1 0.697897653160778 89 552 475 545 192 246 199 252 543 532 394 457 M17699 GO_NUCLEOLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLUS.html A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. 971/1232 Gene Ontology CC GO:0005730 0.327018304704523 0.410362062706972 570 419.727272727273 394 0.0388297387967394 174 0.876080104467554 0.859262206590573 1 0.516006096960605 174 575 570 579 314 352 222 364 394 569 504 458 M17483 GO_SPERM_PRINCIPAL_PIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PRINCIPAL_PIECE.html The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. 20/29 Gene Ontology CC GO:0097228 0.232151397304621 0.306671000513725 495 347 395 0.0237287300377173 156 1.03878317622106 -1.01038192395303 -1 0.83860399317274 494 437 233 290 395 491 423 224 156 182 492 459 M17065 GO_PLATELET_ALPHA_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE.html A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). 71/117 Gene Ontology CC GO:0031091 0.00038729398469879 0.00258641155298847 190 321.636363636364 396 3.52147437994412e-05 49 1.39959176285103 1.37731121791017 1 5.96448679943676 187 418 49 510 189 455 256 396 526 129 423 460 M17336 GO_CONTRACTILE_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_FIBER.html Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. 205/299 Gene Ontology CC GO:0043292 0.0742056726497414 0.123035647545381 500 371.090909090909 396 0.0069848713846131 97 1.13059543908142 -1.16720248433287 -1 1.66123865714322 497 520 97 552 190 244 572 510 383 121 396 461 M17538 GO_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN.html A compact and highly condensed form of chromatin. 76/86 Gene Ontology CC GO:0000792 0.348330172539059 0.427864334556434 400 410.090909090909 396 0.038180850668177 225 1.24498334914809 -1.30708683098589 -1 0.715404163568212 316 469 373 568 461 388 396 548 400 367 225 462 M17187 GO_MCM_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MCM_COMPLEX.html A hexameric protein complex required for the initiation and regulation of DNA replication. 11/11 Gene Ontology CC GO:0042555 0.668068603345727 0.690946349517695 410 369.090909090909 397 0.0953950926697729 151 0.666045136342382 -0.689755347652121 -1 0.130960090104836 151 402 280 406 366 397 322 327 485 514 410 463 M17227 GO_ACTIN_FILAMENT_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE.html An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. 83/106 Gene Ontology CC GO:0032432 0.0152564214595245 0.0331984302171675 400 358.727272727273 397 0.00139665994828657 97 0.963312329119692 0.852745975193314 1 2.31828728578416 400 292 152 397 97 380 569 509 457 203 490 464 M17131 GO_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INCLUSION_BODY.html A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. 78/96 Gene Ontology CC GO:0016234 0.0390711039978262 0.0728004624235115 250 353.727272727273 399 0.00361661354576674 149 0.779753218149678 0.826229855015163 1 1.42626568748014 249 467 399 463 149 283 153 264 548 418 498 465 M17470 GO_AXONEME_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_PART.html Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 18/32 Gene Ontology CC GO:0044447 0.68618940391 0.690946349517695 500 395.818181818182 399 0.1 163 1.44585474051078 -1.63553711598865 -1 0.338793457690334 498 347 163 399 559 501 388 495 183 271 550 466 M17618 GO_LATERAL_ELEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_ELEMENT.html A proteinaceous core found between sister chromatids during meiotic prophase. 8/115 Gene Ontology CC GO:0000800 0.0239411985660322 0.0476364259139203 560 350.909090909091 400 0.00242031101401557 126 1.0574255124232 -1.13330662148354 -1 2.27405755656835 488 454 558 400 126 517 186 168 249 155 559 467 M17846 GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX.html A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. 61/70 Gene Ontology CC GO:0030532 0.111780914384028 0.166952985236813 275 391.454545454545 400 0.0107182232059446 226 0.472548448367052 -0.476250234856968 -1 0.563257883302634 274 472 491 490 226 278 233 358 503 581 400 468 M17130 GO_CHROMOSOMAL_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOMAL_REGION.html Any subdivision of a chromosome along its length. 337/530 Gene Ontology CC GO:0098687 0.68618940391 0.690946349517695 505 405.272727272727 401 0.1 186 0.937906744376611 -1.03886140160787 -1 0.203416127082243 255 517 503 573 505 349 401 367 186 473 329 469 M17452 GO_SPINDLE_MIDZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MIDZONE.html The area in the center of the spindle where the spindle microtubules from opposite poles overlap. 29/32 Gene Ontology CC GO:0051233 0.68618940391 0.690946349517695 395 449.818181818182 401 0.1 335 0.888215290096749 -0.916835641649511 -1 0.190172455514209 395 554 369 567 541 502 392 401 497 335 395 470 M17732 GO_SPERM_FLAGELLUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_FLAGELLUM.html A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. 52/88 Gene Ontology CC GO:0036126 0.68618940391 0.690946349517695 540 379.363636363636 402 0.1 94 1.04481114998538 -1.15366704292352 -1 0.231908085258483 540 336 217 282 567 402 517 544 94 161 513 471 M17124 GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription. 25/28 Gene Ontology CC GO:0090568 0.0533169673809761 0.0944425550254486 345 392.090909090909 403 0.00496861074712524 132 0.69434380682199 -0.613967662453022 -1 1.13466050061592 403 482 392 480 550 342 365 132 413 411 343 472 M17250 GO_NODE_OF_RANVIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NODE_OF_RANVIER.html An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. 19/32 Gene Ontology CC GO:0033268 0.279413370502571 0.360753707248876 445 381.454545454545 403 0.0293506193276443 113 1.20361861541588 -1.31827882294284 -1 0.838128523479861 441 393 113 415 288 510 305 403 515 280 533 473 M17527 GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX.html A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. 18/26 Gene Ontology CC GO:0034663 0.074329625281289 0.123035647545381 520 395.909090909091 403 0.00699695872765504 141 0.710806954585912 -0.737423968522822 -1 1.02713803898689 517 564 247 467 245 403 332 141 577 376 486 474 M17653 GO_TOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_COMPLEX.html A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. 15/17 Gene Ontology CC GO:0038201 0.069135509789939 0.1167666604301 295 394.090909090909 404 0.00649170680081797 185 1.00742490766713 1.00742490766713 1 1.51316800624029 298 503 295 536 185 458 576 270 516 294 404 475 M17556 GO_SMN_SM_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_SM_PROTEIN_COMPLEX.html A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. 16/21 Gene Ontology CC GO:0034719 0.720641265277584 0.72438161786553 570 411.909090909091 406 0.10946475143146 204 0.465719308073561 -0.465719308073561 -1 0.0617036080295716 204 567 416 569 406 268 238 350 566 555 392 476 M17567 GO_POLYSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSOME.html A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. 45/60 Gene Ontology CC GO:0005844 0.68618940391 0.690946349517695 425 354.545454545455 406 0.1 138 0.777361728333682 -0.926317838285647 -1 0.160627975775935 283 423 446 409 421 291 241 377 138 406 465 477 M17039 GO_CYTOPLASMIC_STRESS_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_STRESS_GRANULE.html A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. 36/44 Gene Ontology CC GO:0010494 0.68618940391 0.690946349517695 505 416 408 0.1 161 0.960746919957714 -1.14757413725551 -1 0.209503447092012 327 476 397 503 405 473 502 394 161 408 530 478 M17208 GO_M_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_M_BAND.html The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. 28/40 Gene Ontology CC GO:0031430 0.30090416027328 0.3817146661982 555 398.181818181818 408 0.03201868465018 237 0.936603329978033 -0.588920642842102 -1 0.603732805852112 422 551 298 432 354 555 511 237 238 374 408 479 M17003 GO_MICROTUBULE_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. 1124/1355 Gene Ontology CC GO:0015630 0.353419475922115 0.433199821752634 450 377.818181818182 409 0.0426686923659322 169 0.973262134317332 -0.981533807708401 -1 0.540409417774743 409 360 511 391 556 183 446 448 169 443 240 480 M17719 GO_EXTRINSIC_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 257/326 Gene Ontology CC GO:0019898 0.68618940391 0.690946349517695 455 340.272727272727 409 0.1 143 1.09609047839814 -1.12613740614693 -1 0.245574954010262 567 237 209 162 409 549 452 452 152 143 411 481 M17186 GO_BASAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 43/58 Gene Ontology CC GO:0009925 0.0083110680149696 0.0205477894327546 410 337.181818181818 410 0.000758421116905693 53 1.45740484041268 1.53724604680164 1 4.03529469491441 410 254 64 311 528 494 518 487 158 53 432 482 M17433 GO_CELL_CELL_ADHERENS_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHERENS_JUNCTION.html An adherens junction which connects a cell to another cell. 68/93 Gene Ontology CC GO:0005913 0.68618940391 0.690946349517695 375 429.272727272727 410 0.1 243 0.993641754623474 0.819553903095406 1 0.218270515653631 372 417 243 561 399 505 402 410 523 342 548 483 M17103 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX.html A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. 99/124 Gene Ontology CC GO:0090575 0.478467461824786 0.555979190640401 415 379.363636363636 412 0.0574632123756607 267 0.870780642266175 0.987788582294142 1 0.321957860724768 336 412 448 298 429 419 328 267 356 412 468 484 M17297 GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX.html A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. 74/83 Gene Ontology CC GO:0070603 0.68618940391 0.690946349517695 415 413.454545454545 413 0.1 272 0.662555528058898 -0.541977502761392 -1 0.130030046364372 456 413 479 413 507 390 407 314 272 454 443 485 M17269 GO_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME.html A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. 501/765 Gene Ontology CC GO:0000228 0.589943589776455 0.660418546551292 315 417.090909090909 415 0.0852880337832706 295 0.95514296946771 -1.05022298634613 -1 0.239125661930347 312 515 526 482 491 316 406 415 362 468 295 486 M17689 GO_DENDRITE_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_CYTOPLASM.html All of the contents of a dendrite, excluding the surrounding plasma membrane. 19/26 Gene Ontology CC GO:0032839 0.631779384208171 0.690946349517695 530 404.454545454545 416 0.08682233273155 188 1.28226233999664 -1.10695166456148 -1 0.295193123290108 526 486 188 328 569 416 494 539 382 224 297 487 M17603 GO_NUCLEAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MATRIX.html The dense fibrillar network lying on the inner side of the nuclear membrane. 114/158 Gene Ontology CC GO:0016363 0.130898107749727 0.187782223710102 420 377.818181818182 417 0.0126730939380983 182 0.968897863701188 1.03103202447472 1 1.1216607265994 220 531 417 511 383 373 244 182 417 421 457 488 M17797 GO_U12_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U12_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. 29/35 Gene Ontology CC GO:0005689 0.217208124705896 0.290778618557894 420 416.363636363636 417 0.0220166013313108 273 0.557451529832894 -0.557446653964976 -1 0.449841905119948 361 430 460 438 273 331 375 417 501 577 417 489 M17325 GO_RIBONUCLEOPROTEIN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_GRANULE.html A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. 167/225 Gene Ontology CC GO:0035770 0.486485256080118 0.564167532500098 155 402.909090909091 419 0.0587897916901183 154 0.90439044629042 0.857606556686924 1 0.326649041331323 154 581 463 553 494 306 173 517 359 419 413 490 M17276 GO_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME.html Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. 60/70 Gene Ontology CC GO:0030684 0.127103587341474 0.182790060013357 80 378.818181818182 421 0.0122819882447689 78 0.466687742216144 0.481892735732941 1 0.525204289898233 78 540 497 577 238 272 217 257 547 523 421 491 M17171 GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the cytoplasm. 17/18 Gene Ontology CC GO:0000177 0.68618940391 0.690946349517695 510 421.909090909091 424 0.1 259 0.853185474692524 -0.593198550542442 -1 0.180836375960377 510 494 337 475 407 469 424 328 259 369 569 492 M17440 GO_SMOOTH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_ENDOPLASMIC_RETICULUM.html The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. 43/64 Gene Ontology CC GO:0005790 0.0123067049049579 0.0283737918642085 425 393.636363636364 424 0.00112509928188541 81 0.757367370388599 -0.731245414541984 -1 1.89845386908116 506 425 332 347 81 477 524 275 519 424 420 493 M17460 GO_COP9_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_COP9_SIGNALOSOME.html A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. 43/56 Gene Ontology CC GO:0008180 0.457057018461312 0.53755086584215 425 417.818181818182 424 0.0540095598581825 255 0.681996269521611 0.659980220628806 1 0.258637789463158 326 424 339 346 424 440 554 484 560 444 255 494 M17104 GO_INO80_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INO80_TYPE_COMPLEX.html A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. 23/26 Gene Ontology CC GO:0097346 0.0778506721330078 0.12747435277054 420 432.272727272727 425 0.00734093255204577 193 0.469567520430139 -0.487119792280362 -1 0.650742580994648 505 343 453 386 193 542 562 425 419 508 419 495 M17219 GO_SNARE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_COMPLEX.html A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. 47/55 Gene Ontology CC GO:0031201 0.68618940391 0.690946349517695 430 428.363636363636 427 0.1 260 0.862400429837175 0.660410100259564 1 0.18329232822055 518 373 427 439 423 544 561 428 260 413 326 496 M17054 GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of H4 histone acetyltransferase activity. 23/27 Gene Ontology CC GO:1902562 0.776219797098874 0.778901039921323 400 409.363636363636 429 0.127243929045542 258 1.04620508823404 0.811783070366494 1 0.141906718753957 399 438 293 523 487 516 262 429 554 258 344 497 M17514 GO_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIDE_OF_MEMBRANE.html A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. 395/702 Gene Ontology CC GO:0098552 7.16214620547448e-08 1.89145770244576e-06 435 325.727272727273 431 6.51104221694514e-09 15 1.2653842958424 1.30576641663085 1 11.9750576377058 431 165 17 85 446 513 497 478 384 15 552 498 M17371 GO_INTRACELLULAR_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_VESICLE.html Any vesicle that is part of the intracellular region. 1266/1799 Gene Ontology CC GO:0097708 0.000558119680268971 0.00344965461953481 435 352.363636363636 432 5.58259903746989e-05 30 1.16487957553785 1.17468379217999 1 4.71457325711239 432 147 532 237 215 487 442 563 340 30 451 499 M17554 GO_IMMUNOGLOBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_COMPLEX.html A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. 3/117 Gene Ontology CC GO:0019814 0.0214293927146264 0.0441833328409351 225 382.636363636364 432 0.00216388901446178 97 1.53434144182722 -1.53434144182722 -1 3.40392687796533 221 513 553 476 535 325 432 97 571 228 258 500 M17101 GO_PERINUCLEAR_REGION_OF_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_REGION_OF_CYTOPLASM.html Cytoplasm situated near, or occurring around, the nucleus. 774/983 Gene Ontology CC GO:0048471 0.311845532182111 0.394732579951648 515 349.909090909091 433 0.0366843998935361 48 1.11284575933643 -1.13878782395634 -1 0.699194097119225 509 154 515 48 433 429 512 459 250 102 438 501 M17357 GO_GLIAL_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_PROJECTION.html A prolongation or process extending from a glial cell. 22/32 Gene Ontology CC GO:0097386 0.00749957731308859 0.019110764995195 530 400.363636363636 434 0.000684115026523025 64 0.931135793229503 -1.07627481113996 -1 2.61000731035268 528 434 231 534 64 550 530 260 494 397 382 502 M17563 GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR.html A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. 22/26 Gene Ontology CC GO:0030687 0.557503495149071 0.633045431046237 560 421.636363636364 434 0.0714399691100032 163 0.450365077792513 0.450365077792513 1 0.101893083745865 163 558 458 572 434 333 293 288 552 556 431 503 M17570 GO_EXOCYST http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYST.html A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. 20/21 Gene Ontology CC GO:0000145 0.271814443128443 0.352509355932199 390 423.090909090909 434 0.0284245084824334 189 0.738058787668259 -0.733731203478762 -1 0.508234379186701 387 491 318 434 293 407 540 465 573 557 189 504 M17799 GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX.html Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. 8/14 Gene Ontology CC GO:0005890 0.000685537500192361 0.00394353750110655 485 377.545454545455 434 6.85749074807155e-05 16 3.93695080118019 -3.93695080118019 -1 15.6648905238115 481 512 578 509 468 434 249 16 202 301 403 505 M17706 GO_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE.html Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. 82/99 Gene Ontology CC GO:0005643 0.68618940391 0.690946349517695 480 401.818181818182 435 0.1 172 0.727489730162269 -0.662915505744668 -1 0.147336185994459 477 334 477 337 490 525 399 325 172 449 435 506 M17247 GO_SET1C_COMPASS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SET1C_COMPASS_COMPLEX.html A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. 9/11 Gene Ontology CC GO:0048188 0.267331299377119 0.347470883530439 525 412.727272727273 436 0.030627346473731 220 0.16430826930509 0.149637439527278 1 0.0786602731504022 392 358 524 466 291 361 220 447 524 521 436 507 M16979 GO_I_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_BAND.html A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. 134/198 Gene Ontology CC GO:0031674 0.0844054013764282 0.135468337568245 355 359.181818181818 438 0.00798446168869614 104 1.09218716387272 -1.11778617814673 -1 1.5274261748895 353 461 104 555 200 438 449 241 475 181 494 508 M17301 GO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. 413/549 Gene Ontology CC GO:0000785 0.255444091513273 0.33501809744743 345 392.727272727273 438 0.0264588765852103 184 1.02813095097949 -1.11722374110255 -1 0.763998596824426 344 458 473 502 466 312 465 335 343 438 184 509 M17704 GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX.html Any complex formed of proteins that act in nucleotide-excision repair. 15/16 Gene Ontology CC GO:0000109 0.0575623645878817 0.0995349220998788 440 384.181818181818 439 0.00537509594011686 133 0.524714028063241 -0.53657551927292 -1 0.826221538661916 443 439 357 472 174 293 133 507 439 570 399 510 M17721 GO_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE.html The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. 342/399 Gene Ontology CC GO:0005819 0.68618940391 0.690946349517695 380 442.727272727273 440 0.1 310 0.921476840478652 -0.93759517256124 -1 0.199037260448688 378 579 483 554 526 362 493 404 310 440 341 511 M17526 GO_U2_TYPE_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. 15/18 Gene Ontology CC GO:0071004 0.329846210591665 0.41213042656722 380 445.727272727273 445 0.0357321660904521 306 0.455221880989008 -0.354479224549436 -1 0.244348388177763 379 504 367 445 306 462 387 409 572 548 524 512 M17745 GO_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_PREINITIATION_COMPLEX.html A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. 16/16 Gene Ontology CC GO:0070993 0.591110250746294 0.660452030160763 305 400.272727272727 445 0.0780837398915387 146 0.584083884325302 0.584083884325302 1 0.12812233284848 146 568 445 518 539 211 304 324 470 574 304 513 M17642 GO_NUCLEAR_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PERIPHERY.html The portion of the nuclear lumen proximal to the inner nuclear membrane. 137/182 Gene Ontology CC GO:0034399 0.3837821129607 0.466479932280683 465 416.545454545455 446 0.0430594976629552 251 0.936142314691122 1.01755118711041 1 0.468070985568677 263 528 465 516 464 411 312 251 423 446 503 514 M17516 GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE.html The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. 14/14 Gene Ontology CC GO:0000940 0.417207138842246 0.500820966254845 255 412.727272727273 447 0.0478988028940791 158 0.922635242804285 0.922635242804285 1 0.413398168662337 254 447 304 426 396 466 158 571 510 547 461 515 M17544 GO_SARCOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASM.html The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. 72/102 Gene Ontology CC GO:0016528 0.545612391657014 0.621570195201421 450 394.454545454545 448 0.0691987611234132 131 1.00492067941244 -0.930558676750274 -1 0.297934558333155 566 296 131 448 545 344 448 476 504 157 424 516 M17114 GO_CYTOSOLIC_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PART.html Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. 219/339 Gene Ontology CC GO:0044445 0.579156229908521 0.650850618137041 215 421.909090909091 449 0.0756654788313307 212 0.838481052108658 -0.805914104968249 -1 0.213054144427576 212 580 499 549 560 366 263 298 391 474 449 517 M17102 GO_NUCLEOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLAR_PART.html Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. 60/65 Gene Ontology CC GO:0044452 0.0707572296268816 0.119159276560053 295 425.363636363636 451 0.00664918206199159 187 0.803569900954806 -0.633504509214252 -1 1.18580411203864 291 542 485 575 187 449 364 318 499 451 518 518 M17714 GO_CYTOPLASMIC_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE.html Any microtubule in the cytoplasm of a cell. 66/84 Gene Ontology CC GO:0005881 0.363591927746651 0.443796029455471 455 330.090909090909 451 0.0402507330952198 57 1.17268420199029 1.13288643606983 1 0.640248311326916 451 191 158 88 474 535 481 516 57 107 573 519 M17145 GO_SPINDLE_POLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_POLE.html Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. 146/171 Gene Ontology CC GO:0000922 0.68618940391 0.690946349517695 455 425.818181818182 452 0.1 191 0.883895386502424 -0.951377456582285 -1 0.18902112305196 452 460 459 498 525 389 454 436 191 395 425 520 M17220 GO_DNA_REPLICATION_FACTOR_A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_FACTOR_A_COMPLEX.html A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. 14/14 Gene Ontology CC GO:0005662 0.0671904866383712 0.113812456958874 530 427.454545454545 452 0.00630316615167134 184 0.592976520652552 -0.638482526174325 -1 0.88246303192223 527 445 323 471 184 547 436 462 336 519 452 521 M17768 GO_MAST_CELL_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_GRANULE.html Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. 22/48 Gene Ontology CC GO:0042629 0.0110289720018177 0.0261544193185964 430 393.636363636364 452 0.00100769575391914 67 1.07752673140262 1.12195524143637 1 2.78392927643435 427 390 164 452 546 558 488 67 493 249 496 522 M17080 GO_CYTOPLASMIC_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SIDE_OF_MEMBRANE.html The side of a membrane that faces the cytoplasm. 184/232 Gene Ontology CC GO:0098562 0.00577426225782821 0.0159754589133247 175 353.909090909091 453 0.000526315789473684 30 1.10388531399473 -1.16226181753102 -1 3.2454748179023 480 173 173 30 581 571 453 514 281 109 528 523 M17390 GO_HISTONE_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_COMPLEX.html A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. 84/95 Gene Ontology CC GO:0035097 0.68618940391 0.690946349517695 455 457.454545454545 453 0.1 360 0.865867281327077 0.776607568111006 1 0.184216306863816 360 466 487 525 448 453 405 513 412 453 510 524 M17533 GO_MIDBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBODY.html A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. 172/198 Gene Ontology CC GO:0030496 0.68618940391 0.690946349517695 430 457.818181818182 453 0.1 349 0.884290044679168 0.889451667226792 1 0.189126306596096 523 408 429 504 453 518 459 430 349 436 527 525 M17188 GO_NUCLEAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_BODY.html Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. 396/505 Gene Ontology CC GO:0016604 0.432334946144298 0.516844863600488 580 410.545454545455 455 0.0501724948250593 100 0.816941567884671 0.817421713640556 1 0.342159521912528 100 578 507 574 580 285 162 340 455 489 446 526 M17650 GO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. 147/223 Gene Ontology CC GO:0000781 0.68618940391 0.690946349517695 445 428.181818181818 455 0.1 151 0.957337697388608 -1.1034195461801 -1 0.208594827598743 442 410 461 532 455 472 515 460 151 447 365 527 M17061 GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 247/294 Gene Ontology CC GO:0061695 0.68618940391 0.690946349517695 420 449.545454545455 457 0.1 213 0.818095874938891 -0.783598353603843 -1 0.171484362795828 544 363 496 417 416 457 580 518 213 456 485 528 M17246 GO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME.html A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. 553/639 Gene Ontology CC GO:0005813 0.536709033417066 0.613834544124636 430 415 457 0.0740545899222856 204 0.910510766547795 -0.934140374269131 -1 0.273791185364132 426 457 523 497 532 204 471 443 253 465 294 529 M17663 GO_INTERCELLULAR_BRIDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCELLULAR_BRIDGE.html A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. 49/52 Gene Ontology CC GO:0045171 0.456705738091506 0.53755086584215 545 453.545454545455 457 0.0539539353693108 254 0.687755810000874 -0.62794760194748 -1 0.261215162271169 369 545 468 544 449 387 435 568 513 457 254 530 M17571 GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX.html RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 19/21 Gene Ontology CC GO:0005666 0.363555839126313 0.443796029455471 460 467.545454545455 458 0.0402457855643845 318 0.493030227130129 -0.660384168726014 -1 0.242198066724555 394 566 457 576 318 385 400 458 561 558 470 531 M17750 GO_MICROTUBULE_ORGANIZING_CENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER.html An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. 703/819 Gene Ontology CC GO:0005815 0.626268252570353 0.690946349517695 575 412.545454545455 458 0.0937333487399365 206 0.90511724215019 -0.924788287896598 -1 0.19467713152135 458 361 574 393 572 233 495 475 206 466 305 532 M17349 GO_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE.html Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. 403/498 Gene Ontology CC GO:0005874 0.597773408510635 0.664065679435332 515 381.454545454545 459 0.0794597169791477 119 1.11221090249851 -1.15571317199253 -1 0.28168813258298 512 516 310 261 489 459 557 468 119 221 284 533 M17614 GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME.html Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. 101/110 Gene Ontology CC GO:0016591 0.448125219195872 0.530375855089266 495 401.909090909091 459 0.0526052822906758 178 0.673743717111563 -0.650616240365003 -1 0.261471564177034 269 533 495 542 459 178 236 424 495 477 313 534 M17155 GO_TRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX.html A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). 713/832 Gene Ontology CC GO:1990234 0.6513215599 0.690946349517695 460 478 460 0.1 376 0.798477034749334 -0.77528069614989 -1 0.166255586947311 558 456 518 407 442 460 546 570 376 492 433 535 M17289 GO_NUCLEAR_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_REPLICATION_FORK.html The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 41/42 Gene Ontology CC GO:0043596 0.34752116473503 0.427774993031891 550 464.636363636364 460 0.0380723628717327 312 0.587509143547551 -0.577043898690215 -1 0.313103959130921 549 375 425 373 312 537 574 549 460 442 515 536 M17469 GO_MISMATCH_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR_COMPLEX.html Any complex formed of proteins that act in mismatch repair. 10/12 Gene Ontology CC GO:0032300 0.874723717842822 0.876231862183931 365 445.636363636364 460 0.17208056446086 345 0.488740949329149 -0.488740949329149 -1 0 375 510 345 486 521 364 460 365 557 543 376 537 M16999 GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX.html A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. 24/29 Gene Ontology CC GO:0005669 0.394072421557446 0.476000159926977 465 448.181818181818 462 0.0445233781283819 299 0.805301650654659 0.845802200970507 1 0.38441508516888 462 433 344 437 326 495 559 299 551 499 525 538 M17430 GO_SYNAPTONEMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX.html A proteinaceous scaffold found between homologous chromosomes during meiosis. 31/151 Gene Ontology CC GO:0000795 0.68618940391 0.690946349517695 350 425.636363636364 462 0.1 245 1.05316876838908 0.74449982037577 1 0.234135541766521 555 481 245 462 549 527 348 345 518 304 348 539 M17018 GO_TRANSCRIPTION_EXPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_EXPORT_COMPLEX.html The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. 20/40 Gene Ontology CC GO:0000346 0.448217805247555 0.530375855089266 290 426.454545454545 463 0.0526197325755836 265 0.842559090716796 0.842559090716796 1 0.338651178083981 286 490 412 558 499 507 477 265 350 384 463 540 M17153 GO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAJAL_BODY.html A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. 57/64 Gene Ontology CC GO:0015030 0.477181011179264 0.55559552604239 460 468 464 0.0572520916363986 339 0.647506936651809 -0.699730286553759 -1 0.227791565774512 529 421 456 531 339 539 398 501 456 464 514 541 M17288 GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex that possesses activity that prevents or downregulates transcription. 84/99 Gene Ontology CC GO:0017053 0.68618940391 0.690946349517695 420 464.090909090909 464 0.1 370 0.899266148144838 -0.82999876049923 -1 0.193117709112737 464 468 418 539 537 476 428 370 418 431 556 542 M17498 GO_PRP19_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRP19_COMPLEX.html A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. 19/20 Gene Ontology CC GO:0000974 0.0658483402006994 0.112193213069227 575 432.454545454545 464 0.0061732735871085 181 0.683772028011178 -0.751597380235951 -1 1.03177592354198 572 562 283 442 181 545 513 233 581 381 464 543 M17134 GO_NUCLEAR_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INCLUSION_BODY.html An intranuclear focus at which aggregated proteins have been sequestered. 14/14 Gene Ontology CC GO:0042405 0.27795963747575 0.359676056510938 505 462.727272727273 465 0.0291727626282465 287 0.60306222076279 -0.454507410867085 -1 0.398009342425402 406 446 385 505 287 575 549 461 465 510 501 544 M17448 GO_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases. 22/25 Gene Ontology CC GO:0000178 0.68618940391 0.690946349517695 400 424.454545454545 465 0.1 230 0.853185474692524 -0.593198550542442 -1 0.180836375960377 465 555 398 479 497 311 230 519 311 398 506 545 M16989 GO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME.html A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. 863/1183 Gene Ontology CC GO:0005694 0.557864476240401 0.633045431046237 330 430.818181818182 467 0.0783722537688123 283 0.93402070075463 -1.00478783047015 -1 0.261312144289177 329 514 510 565 547 324 467 372 341 487 283 546 M17422 GO_MLL1_2_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MLL1_2_COMPLEX.html A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. 31/35 Gene Ontology CC GO:0044665 0.68618940391 0.690946349517695 400 471.818181818182 472 0.1 398 0.62465879044888 0.65660133251024 1 0.119929880175225 398 480 472 489 508 456 529 435 421 535 467 547 M17320 GO_PLATELET_ALPHA_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet alpha granule. 51/92 Gene Ontology CC GO:0031093 0.00293700544523339 0.0115297308356797 350 379.363636363636 473 0.000267357608968615 57 1.34333971907049 1.20937032295942 1 4.27541144546905 349 473 57 508 127 572 346 580 534 101 526 548 M17539 GO_DNA_HELICASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_COMPLEX.html A protein complex that possesses DNA helicase activity. 15/18 Gene Ontology CC GO:0033202 0.507685141279899 0.584089241749745 510 436 475 0.0623903127241521 273 0.502481493195447 0.470419052788217 1 0.148228045079901 508 273 411 326 343 536 475 498 387 550 489 549 M17205 GO_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_COMPLEX.html An ion channel complex through which sodium ions pass. 8/17 Gene Ontology CC GO:0034706 0.6513215599 0.690946349517695 580 455.636363636364 476 0.1 154 1.75732723797994 -1.76844075007862 -1 0.421806513330132 579 509 520 450 476 424 568 374 532 154 426 550 M17248 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY.html A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. 71/84 Gene Ontology CC GO:0000932 0.68618940391 0.690946349517695 440 481.454545454545 480 0.1 355 0.752371030245721 -0.541893045031099 -1 0.153967502611498 440 537 474 562 414 534 480 524 355 439 537 551 M16982 GO_RNA_CAP_BINDING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING_COMPLEX.html Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. 15/20 Gene Ontology CC GO:0034518 0.68618940391 0.690946349517695 575 473.727272727273 482 0.1 400 0.54237910594708 -0.525994922135324 -1 0.0980008556768441 574 448 400 464 403 418 514 497 517 494 482 552 M17120 GO_NUCLEAR_SPECK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_SPECK.html A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. 232/306 Gene Ontology CC GO:0016607 0.595478400231413 0.662783430142626 100 418.636363636364 482 0.0789834616410458 97 0.824696531345038 0.83848115476785 1 0.197984592469553 97 521 501 550 529 355 198 406 488 482 478 553 M17718 GO_PIGMENT_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE.html A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. 115/141 Gene Ontology CC GO:0048770 0.68618940391 0.690946349517695 555 470.818181818182 484 0.1 282 0.954071370834394 -0.835247354674545 -1 0.207724292478674 541 530 282 519 420 484 552 434 469 393 555 554 M17099 GO_RNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_COMPLEX.html Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. 124/133 Gene Ontology CC GO:0030880 0.518301408299169 0.595124739568808 505 417.727272727273 485 0.0642466342525186 219 0.655886467698462 -0.643681813750637 -1 0.198843417478619 346 529 504 546 344 219 266 492 502 485 362 555 M17429 GO_NUCLEOPLASM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPLASM_PART.html Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. 746/883 Gene Ontology CC GO:0044451 0.6513215599 0.690946349517695 580 460.909090909091 486 0.1 264 0.811743551834432 0.801168645844997 1 0.169791353764221 264 577 537 580 486 414 270 471 401 536 534 556 M17071 GO_U2_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. 32/43 Gene Ontology CC GO:0005684 0.088486365105398 0.141237851995155 545 459.454545454545 487 0.00838724065813912 203 0.483093424043191 -0.446979935938025 -1 0.635119979386228 391 429 464 487 203 526 496 467 541 506 544 557 M17425 GO_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLTRANSFERASE_COMPLEX.html A protein complex that possesses methyltransferase activity. 103/119 Gene Ontology CC GO:0034708 0.68618940391 0.690946349517695 465 494 492 0.1 408 0.79008920511058 -0.830545935870706 -1 0.164020078598559 476 463 492 524 408 551 505 567 409 462 577 558 M17553 GO_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATION_FORK.html The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 74/81 Gene Ontology CC GO:0005657 0.68618940391 0.690946349517695 495 487.818181818182 492 0.1 414 0.690150634765181 -0.75892034658292 -1 0.137384641543748 492 414 436 529 436 521 491 575 512 455 505 559 M17555 GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX.html A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. 18/22 Gene Ontology CC GO:0005732 0.68618940391 0.690946349517695 495 475.363636363636 492 0.1 341 0.739324146089594 -0.739324146089594 -1 0.15049027194369 448 492 408 556 524 345 341 541 529 554 491 560 M17290 GO_INVADOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_INVADOPODIUM.html A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. 14/17 Gene Ontology CC GO:0071437 0.121810451883708 0.176049434190135 525 401.090909090909 498 0.0117389924105036 196 1.27173096957147 -0.921637140720579 -1 1.54594182843574 525 565 196 321 237 503 498 547 201 288 531 561 M17022 GO_U1_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U1_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U1. 17/22 Gene Ontology CC GO:0005685 0.346806675461823 0.427774993031891 500 477.727272727273 500 0.0379766516344162 310 0.480050521559518 -0.480050521559518 -1 0.247320744661003 479 501 396 443 310 500 519 551 569 500 487 562 M17031 GO_HOLO_TFIIH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOLO_TFIIH_COMPLEX.html A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. 12/12 Gene Ontology CC GO:0005675 0.668443171438689 0.690946349517695 505 474 500 0.0954879404589776 367 0.565419918995408 -0.636054668324094 -1 0.1041416492015 513 505 388 435 367 443 528 557 477 501 500 563 M17053 GO_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). 105/168 Gene Ontology CC GO:0015934 0.0468668714320567 0.0840421367346448 495 474.363636363636 500 0.00435419207024742 159 0.618525716350775 -0.629368067195922 -1 1.05770459688468 396 535 500 492 159 560 492 505 549 483 547 564 M17529 GO_SEMAPHORIN_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_COMPLEX.html A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. 9/11 Gene Ontology CC GO:0002116 0.0722259812275385 0.120584181302298 340 451.636363636364 500 0.00746867877599645 75 0.622567387767927 -0.595819655835696 -1 0.902882998721223 338 508 552 500 485 430 75 542 535 549 454 565 M17069 GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX.html A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. 16/16 Gene Ontology CC GO:0005671 0.159358362115306 0.22150049853826 505 472.272727272727 504 0.0156570272345468 253 0.492111660825371 -0.521495268753782 -1 0.488205239140779 428 569 435 540 253 504 450 488 511 505 512 566 M17484 GO_CATALYTIC_STEP_2_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_STEP_2_SPLICEOSOME.html A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. 103/158 Gene Ontology CC GO:0071013 0.68618940391 0.690946349517695 450 513.636363636364 505 0.1 447 0.556669443213415 -0.51365699935508 -1 0.101809489094693 447 536 505 578 498 552 455 577 450 480 572 567 M17107 GO_SMN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_COMPLEX.html A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. 12/13 Gene Ontology CC GO:0032797 0.334731111020665 0.416442774096374 510 448.090909090909 506 0.0363732715610874 261 0.575147473570594 0.575147473570594 1 0.316668687577441 515 506 362 566 307 422 350 261 567 509 564 568 M17657 GO_REPLISOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLISOME.html A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. 28/29 Gene Ontology CC GO:0030894 0.68618940391 0.690946349517695 545 497.454545454545 508 0.1 418 0.556814172297261 -0.618719103846491 -1 0.101848062013931 543 479 421 528 418 574 426 508 467 565 543 569 M17590 GO_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SUBUNIT.html Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. 175/272 Gene Ontology CC GO:0044391 0.68618940391 0.690946349517695 525 494.727272727273 509 0.1 373 0.716781669090309 -0.785158229346726 -1 0.144482293991846 405 525 509 494 373 557 461 545 522 490 561 570 M17140 GO_GEMINI_OF_COILED_BODIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_GEMINI_OF_COILED_BODIES.html Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). 10/11 Gene Ontology CC GO:0097504 0.679407150884692 0.690946349517695 580 468.909090909091 511 0.098248835312509 271 0.243556894537372 -0.294225394131143 -1 0.018359330136959 536 572 340 559 492 408 271 313 580 511 576 571 M17089 GO_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME.html An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. 235/339 Gene Ontology CC GO:0005840 0.68618940391 0.690946349517695 565 513.454545454545 514 0.1 374 0.760165182533288 -0.694042739878128 -1 0.156044785205532 564 519 506 491 514 480 573 569 374 493 565 572 M17241 GO_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of a ribosome. 70/104 Gene Ontology CC GO:0015935 0.0427235685348025 0.0790522080214021 470 486.727272727273 521 0.00396150310996597 153 0.872353594261238 -0.999369702304081 -1 1.54935951426258 483 539 470 548 153 553 521 578 468 463 578 573 M17540 GO_CHROMOCENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOCENTER.html A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure. 13/17 Gene Ontology CC GO:0010369 0.594803883362419 0.662783430142626 525 467.545454545455 524 0.0788439543508808 302 0.779301623879478 -0.993483979500233 -1 0.184524173463052 524 354 302 376 355 556 553 525 539 551 508 574 M17542 GO_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX.html Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. 190/251 Gene Ontology CC GO:0005681 0.68618940391 0.690946349517695 495 520 524 0.1 460 0.590240399671476 0.588126370726675 1 0.110756756346146 460 524 508 493 533 538 489 581 533 491 570 575 M17551 GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX.html RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 13/15 Gene Ontology CC GO:0005736 0.318838959371664 0.401833916257997 570 485.636363636364 528 0.0343029806717595 300 0.677106350039649 -0.660384168726014 -1 0.398490050818527 495 570 379 570 300 559 506 322 528 553 560 576 M17478 GO_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. 20/24 Gene Ontology CC GO:0071010 0.29546527883048 0.376459050439712 545 504.090909090909 529 0.031336477558414 295 0.457535773700288 -0.424726185790858 -1 0.275688137063447 503 499 415 543 295 577 508 529 570 544 562 577 M17379 GO_VOLTAGE_GATED_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_COMPLEX.html A sodium channel in a cell membrane whose opening is governed by the membrane potential. 5/14 Gene Ontology CC GO:0001518 0.887571644843969 0.887571644843969 560 480 533 0.196311811540985 272 1.46911405399095 -1.46911405399095 -1 0.0797628012906344 557 574 533 478 422 392 564 382 568 272 538 578 M17672 GO_RNAI_EFFECTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNAI_EFFECTOR_COMPLEX.html Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. 11/11 Gene Ontology CC GO:0031332 0.189237505640606 0.256286691788326 535 497.272727272727 534 0.0188902208019617 268 0.17366701389364 -0.152001986407619 -1 0.123900980081705 534 573 401 521 268 543 427 556 564 566 517 579 M17292 GO_EXON_EXON_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXON_EXON_JUNCTION_COMPLEX.html A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. 26/51 Gene Ontology CC GO:0035145 0.68618940391 0.690946349517695 525 506.545454545455 535 0.1 355 0.184096297344615 -0.153809302377878 -1 0.00251200524232133 407 556 471 547 571 540 535 355 544 524 522 580 M17441 GO_ENDORIBONUCLEASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_COMPLEX.html A protein complex which is capable of endoribonuclease activity. 21/22 Gene Ontology CC GO:1902555 0.63352874170601 0.690946349517695 540 497.181818181818 540 0.0872175835178386 352 0.537377017374524 -0.531257043776696 -1 0.0966677085760156 474 559 419 564 362 548 570 543 538 540 352 581 M17739 GO_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX.html A macromolecular complex containing both protein and RNA molecules. 755/991 Gene Ontology CC GO:1990904 0.6513215599 0.690946349517695 575 519.181818181818 564 0.1 416 0.752223640613812 -0.754797801741548 -1 0.153928220608067 416 576 572 551 431 564 451 576 427 573 574