Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M17016 GO_FILOPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a filopodium. 19/22 Gene Ontology CC GO:0031527 1.29945036082206e-06 4.3993507298375e-06 35 67.5454545454545 32 1.18131920759552e-07 10 3.09604785649149 3.21364239749534 1 7.94650572742474 17 93 111 32 263 32 11 10 29 132 13 2 M17059 GO_LATE_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a late endosome. 110/129 Gene Ontology CC GO:0031902 4.18316587410211e-07 3.31471465533457e-06 10 104.363636363636 35 3.80287879045983e-08 1 1.35743302300929 -1.22805722300363 -1 3.54090948711021 20 7 323 307 9 8 35 38 159 241 1 3 M17752 GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. 19/23 Gene Ontology CC GO:0033176 2.15397770399148e-07 2.23475186789116e-06 5 117.090909090909 41 1.95816174080302e-08 1 1.42324055735881 -1.42324055735881 -1 3.83198211559569 9 240 245 232 41 9 1 3 229 275 4 4 M17676 GO_NEUROMUSCULAR_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION.html The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. 91/122 Gene Ontology CC GO:0031594 2.75890445060881e-11 5.17072092194747e-10 20 48.6363636363636 48 2.50809495513038e-12 7 2.81481369835825 3.27449420472641 1 12.5491599161027 18 10 19 75 144 15 55 81 63 48 7 5 M17774 GO_COATED_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_MEMBRANE.html A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. 95/109 Gene Ontology CC GO:0048475 5.48986101954581e-07 3.31471465533457e-06 35 87.1818181818182 49 4.9907839904377e-08 15 1.49988774618094 -1.26078550482381 -1 3.91690801931682 45 15 283 56 32 20 31 93 73 262 49 6 M17227 GO_ACTIN_FILAMENT_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE.html An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. 83/106 Gene Ontology CC GO:0032432 6.4778272886831e-07 3.50797657915001e-06 45 61.9090909090909 50 5.88893563278065e-08 17 2.59235237118211 2.78802834558468 1 6.76965508806368 50 17 41 81 150 59 86 33 44 86 34 7 M17185 GO_CLATHRIN_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT.html A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. 53/66 Gene Ontology CC GO:0030118 7.81651178747937e-07 3.55843005277381e-06 75 88.6363636363636 52 7.10592233150551e-08 27 1.76906904923187 -1.38152133778284 -1 4.60113557658778 71 43 207 52 74 38 27 91 34 296 42 8 M17707 GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX.html Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). 42/45 Gene Ontology CC GO:0030119 3.03317153973561e-06 7.49816897630968e-06 25 123.636363636364 54 2.7574324742007e-07 3 1.28210749279421 -1.32839450678474 -1 3.12315806178658 25 54 300 241 212 11 8 24 187 295 3 9 M17816 GO_CLATHRIN_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_ADAPTOR_COMPLEX.html A membrane coat adaptor complex that links clathrin to a membrane. 31/34 Gene Ontology CC GO:0030131 3.78349586262184e-07 3.23266337674013e-06 70 92.6363636363636 62 3.43954228481508e-08 6 1.39619212076458 -1.51123728226786 -1 3.65053210814047 70 67 269 57 93 39 38 6 62 294 24 10 M17336 GO_CONTRACTILE_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_FIBER.html Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. 205/299 Gene Ontology CC GO:0043292 2.41707556109253e-09 3.26586256045293e-08 80 80.6363636363636 64 2.19734142158918e-10 15 2.49605594986369 2.84766861861565 1 8.95860274301137 85 191 30 77 15 80 255 22 64 37 31 11 M17494 GO_DENDRITE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MEMBRANE.html The portion of the plasma membrane surrounding a dendrite. 22/37 Gene Ontology CC GO:0032590 3.32701990004302e-05 5.02077548551947e-05 45 118.454545454545 64 3.02460928638529e-06 32 3.58199741150491 3.71577287698062 1 7.37594980537932 44 239 87 44 380 64 32 55 158 147 53 12 M17381 GO_CLATHRIN_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_VESICLE_COAT.html A clathrin coat found on a vesicle. 29/32 Gene Ontology CC GO:0030125 7.04717536348501e-07 3.55558405870747e-06 80 90.9090909090909 65 6.40652510989145e-08 30 1.61446749802399 -1.68910027568363 -1 4.19564120373192 43 76 238 58 57 77 33 30 83 240 65 13 M16979 GO_I_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_BAND.html A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. 134/198 Gene Ontology CC GO:0031674 1.65159777684413e-08 1.95832307825804e-07 95 78.4545454545455 68 1.50145253567555e-09 8 2.63598562298498 3.17950963753099 1 8.47547948386538 91 211 37 88 35 71 192 11 68 51 8 14 M17625 GO_T_TUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_TUBULE.html Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. 57/87 Gene Ontology CC GO:0030315 3.04572784579877e-06 7.49816897630968e-06 50 110.818181818182 70 2.76884732943528e-07 19 3.04452052857299 3.57858304336027 1 7.47396144512431 192 38 49 19 232 206 237 48 58 70 70 15 M17629 GO_NEURON_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a neuron projection. 46/74 Gene Ontology CC GO:0032589 4.9174887018555e-06 1.06891196867066e-05 70 108 72 4.47045426688137e-07 33 2.96938000224559 2.95340738456733 1 7.0682162387712 116 46 57 33 244 141 194 68 72 67 150 16 M17383 GO_ESCRT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_COMPLEX.html An endosomal sorting complex required for transport. 28/28 Gene Ontology CC GO:0036452 1.0578188265834e-06 4.14481212794304e-06 290 138 75 9.616539411012e-08 10 1.01700905154309 -0.925220100742379 -1 2.59483897733573 29 75 362 289 110 13 10 36 292 287 15 17 M17616 GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT.html A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. 14/15 Gene Ontology CC GO:0044322 3.00736662255746e-05 4.65941335388236e-05 55 141.090909090909 75 2.73400703053609e-06 18 1.47411520923534 -1.44848547896278 -1 3.03381516413407 52 111 260 250 359 49 18 70 27 281 75 18 M17848 GO_VACUOLAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_MEMBRANE.html The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. 648/795 Gene Ontology CC GO:0005774 5.50928179240115e-07 3.31471465533457e-06 40 165 75 5.50928315824998e-08 2 1.55979873274851 -1.42180547458686 -1 4.0750385643133 36 149 581 270 49 2 75 52 276 314 11 19 M17598 GO_MICROTUBULE_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_END.html Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. 27/27 Gene Ontology CC GO:1990752 4.66020075881971e-06 1.02559721245237e-05 75 122.818181818182 76 4.23655511856978e-07 30 1.62801392887538 1.52028145881117 1 3.87041738049925 74 73 204 205 241 76 30 78 43 277 50 20 M17465 GO_APICOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICOLATERAL_PLASMA_MEMBRANE.html The apical end of the lateral plasma membrane of epithelial cells. 23/27 Gene Ontology CC GO:0016327 3.20309666702711e-07 3.00161155410121e-06 150 127 78 2.91190648489367e-08 5 3.95134283632662 -3.93259388099564 -1 10.4693560832943 147 78 55 68 297 230 292 5 6 158 61 21 M17622 GO_ENDOSOMAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOMAL_PART.html Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. 481/614 Gene Ontology CC GO:0044440 7.16083244877118e-07 3.55558405870747e-06 50 120.363636363636 80 6.50984979960788e-08 7 1.61723789623351 -1.51026130691904 -1 4.2029128074018 47 157 299 37 63 7 96 80 228 289 21 22 M17391 GO_MICROTUBULE_PLUS_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_PLUS_END.html The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. 22/22 Gene Ontology CC GO:0035371 2.38500742565097e-06 6.59852054430101e-06 70 110.909090909091 81 2.16819091929801e-07 13 1.72843965222239 1.48434454865363 1 4.27121620793914 68 81 190 177 183 63 13 129 40 246 30 23 M17414 GO_POSTSYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE.html A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. 158/268 Gene Ontology CC GO:0045211 3.54230625271489e-09 4.67745439278943e-08 70 93.7272727272727 81 3.22027841674409e-10 26 2.60108807999992 2.93967539445052 1 9.1418701755307 67 198 32 89 192 26 113 130 81 43 60 24 M17355 GO_CORTICAL_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_ACTIN_CYTOSKELETON.html The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. 82/106 Gene Ontology CC GO:0030864 5.41296077242033e-07 3.31471465533457e-06 530 263.909090909091 83 4.92087464022321e-08 15 2.52935756316147 2.58411197433636 1 6.63411620671595 527 16 51 83 30 542 469 572 15 61 537 25 M17516 GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE.html The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. 14/14 Gene Ontology CC GO:0000940 8.95307554725538e-06 1.67797964288883e-05 5 107.909090909091 83 8.13919271156209e-07 2 2.5997039658952 2.5997039658952 1 5.93778599523879 4 106 92 265 398 17 2 41 107 83 72 26 M17824 GO_SYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_MEMBRANE.html A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 218/356 Gene Ontology CC GO:0097060 9.5561591173954e-12 1.98290301685955e-10 80 87.9090909090909 83 8.68741737948809e-13 17 2.47827961120284 2.76514363674164 1 11.5406905468875 79 185 17 78 133 44 132 83 103 25 88 27 M17433 GO_CELL_CELL_ADHERENS_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHERENS_JUNCTION.html An adherens junction which connects a cell to another cell. 68/93 Gene Ontology CC GO:0005913 1.365157692523e-08 1.68756727522525e-07 35 104.181818181818 85 1.24105245544925e-09 20 2.9864587729319 3.56010909061874 1 9.70089325152242 118 20 35 70 85 192 288 164 55 34 85 28 M17284 GO_ACTOMYOSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN.html Any complex of actin, myosin, and accessory proteins. 93/116 Gene Ontology CC GO:0042641 1.72622388552964e-06 5.24243919351518e-06 100 82.5454545454545 86 1.56929567273445e-07 12 2.34509440075019 2.67056658025849 1 5.92287861386891 100 12 59 86 160 123 137 27 42 115 47 29 M17092 GO_GLYCOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_COMPLEX.html A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. 17/23 Gene Ontology CC GO:0090665 6.11827936917492e-06 1.25166208221501e-05 5 81.8181818181818 87 5.56208762217893e-07 2 2.48018371089097 2.20078966757511 1 5.81495202782713 87 96 126 95 262 62 22 43 4 101 2 30 M17357 GO_GLIAL_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_PROJECTION.html A prolongation or process extending from a glial cell. 22/32 Gene Ontology CC GO:0097386 2.2798450843014e-06 6.36822112489958e-06 45 95.9090909090909 87 2.07258858808439e-07 29 2.52327662689034 2.89875004544255 1 6.27340491837604 111 87 146 43 182 101 43 37 31 245 29 31 M17452 GO_SPINDLE_MIDZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MIDZONE.html The area in the center of the spindle where the spindle microtubules from opposite poles overlap. 29/32 Gene Ontology CC GO:0051233 9.96935381226533e-06 1.82144483173779e-05 70 114.727272727273 88 9.06308998992963e-07 41 2.20759170936365 2.3356249838558 1 4.9979804739351 41 69 136 168 300 68 88 54 77 156 105 32 M17128 GO_SITE_OF_POLARIZED_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_POLARIZED_GROWTH.html Any part of a cell where non-isotropic growth takes place. 216/272 Gene Ontology CC GO:0030427 4.47382870483511e-09 5.77620995002044e-08 55 125.545454545455 92 4.06711701266626e-10 33 2.43567199863481 2.54909368074153 1 8.4503196236673 185 189 33 73 53 92 267 199 57 53 180 33 M17212 GO_CORTICAL_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON.html The portion of the cytoskeleton that lies just beneath the plasma membrane. 102/134 Gene Ontology CC GO:0030863 8.2078378310544e-07 3.55877147749448e-06 80 268.545454545455 93 7.46167353933198e-08 8 2.43089879178813 2.53947390769409 1 6.33811385937086 480 8 66 93 81 563 541 553 80 78 411 34 M17725 GO_ACTIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT.html A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. 93/112 Gene Ontology CC GO:0005884 5.09042078586456e-07 3.31471465533457e-06 95 208.545454545455 93 4.62765633063689e-08 13 2.21278189627041 2.69430939652615 1 5.79853853380201 449 13 93 90 22 522 500 170 47 93 295 35 M16974 GO_FILOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM.html Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. 140/172 Gene Ontology CC GO:0030175 3.20184618293616e-08 3.64759339663904e-07 155 96 95 2.91076929957758e-09 9 2.58597410432101 2.75916804976829 1 7.97741041506655 152 205 39 9 31 116 219 95 24 54 112 36 M17825 GO_EXOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an exocytic vesicle 55/80 Gene Ontology CC GO:0099501 5.81100416986211e-07 3.34276576503949e-06 90 162.272727272727 96 5.2827324588739e-08 18 2.52126841344959 -2.52154560472572 -1 6.60832082718425 360 39 86 18 44 368 310 98 96 88 278 37 M17379 GO_VOLTAGE_GATED_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_COMPLEX.html A sodium channel in a cell membrane whose opening is governed by the membrane potential. 5/14 Gene Ontology CC GO:0001518 4.33572101909113e-06 9.84005434410917e-06 50 152.090909090909 97 4.3357294784289e-07 19 4.47565264327766 4.47565264327766 1 10.7524613974398 46 123 533 30 484 97 19 23 59 141 118 38 M17654 GO_WNT_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALOSOME.html A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. 18/21 Gene Ontology CC GO:1990909 4.95512749082205e-06 1.06891196867066e-05 110 110.818181818182 97 4.50467150131173e-07 16 2.23060441650124 2.77584654605659 1 5.29922587362982 106 97 169 49 246 84 107 84 30 231 16 39 M17177 GO_POSTSYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPSE.html The part of a synapse that is part of the post-synaptic cell. 372/552 Gene Ontology CC GO:0098794 2.12443692304499e-12 5.1429077178714e-11 100 100.181818181818 98 1.93130629367912e-13 14 2.39647662657197 2.76869977071421 1 11.8349274580463 98 169 14 80 152 56 173 123 109 30 98 40 M17447 GO_LAMELLIPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a lamellipodium. 32/37 Gene Ontology CC GO:0031258 7.48188454235048e-08 8.20183947001062e-07 35 90.8181818181818 98 6.80171345163513e-09 1 2.46415940367308 2.70865352451225 1 7.18195792661865 33 233 122 133 104 36 98 1 91 142 6 41 M17488 GO_VACUOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PART.html Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. 743/967 Gene Ontology CC GO:0044437 5.11629944981525e-07 3.31471465533457e-06 55 156.090909090909 101 5.11630062775902e-08 1 1.64591441908258 -1.47761625188593 -1 4.30233444430008 54 146 544 219 38 1 95 101 223 284 12 42 M17803 GO_FILAMENTOUS_ACTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMENTOUS_ACTIN.html A two-stranded helical polymer of the protein actin. 34/46 Gene Ontology CC GO:0031941 6.73356028916088e-07 3.55558405870747e-06 10 137.181818181818 101 6.1214203182807e-08 9 2.60773436596309 3.51821321699724 1 6.80271876292637 262 57 114 101 54 389 359 15 9 139 10 43 M17343 GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX.html A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. 284/408 Gene Ontology CC GO:0005578 1.83945844532104e-57 3.56241785577174e-55 5 116.727272727273 102 1.67223495029185e-58 1 3.56586370742878 3.78370379145917 1 93.4798555787506 1 265 2 162 334 102 117 77 124 6 94 44 M17632 GO_SARCOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOLEMMA.html The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. 145/199 Gene Ontology CC GO:0042383 4.03366426916776e-11 7.32362168870771e-10 190 109.909090909091 102 3.66696751749246e-12 8 2.82862831679406 3.03256049151451 1 12.4049775041483 114 203 21 8 187 74 187 192 94 27 102 45 M17801 GO_PLASMA_MEMBRANE_RAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RAFT.html A membrane raft that is part of the plasma membrane. 114/155 Gene Ontology CC GO:0044853 1.40977760793158e-06 4.65386812618323e-06 105 107.181818181818 102 1.28161682848106e-07 5 2.27766526684804 2.79597653235506 1 5.80811306604229 102 5 79 130 141 103 196 14 281 84 44 46 M17057 GO_ENDOSOME_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_LUMEN.html The volume enclosed by the membrane of an endosome. 24/42 Gene Ontology CC GO:0031904 1.28990857402656e-05 2.23712501943113e-05 90 128.363636363636 103 1.17265103373401e-06 16 3.14904068001989 -3.66278346816942 -1 7.01188505948612 90 85 131 103 318 113 64 146 16 311 35 47 M17791 GO_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a transport vesicle. 154/216 Gene Ontology CC GO:0030658 4.29003352407736e-07 3.31471465533457e-06 100 113.363636363636 103 3.90003123694606e-08 10 2.08042570741134 -1.96767961633093 -1 5.44919432371565 96 200 103 27 10 138 133 72 207 95 166 48 M17199 GO_HOPS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOPS_COMPLEX.html A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. 16/16 Gene Ontology CC GO:0030897 2.77816172295702e-06 7.20585696891978e-06 20 147.545454545455 104 2.52560475566184e-07 5 1.03576914110905 -1.03576914110905 -1 2.52364781845563 28 104 307 315 287 14 5 17 212 317 17 49 M17690 GO_CORNIFIED_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORNIFIED_ENVELOPE.html A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). 16/67 Gene Ontology CC GO:0001533 4.06970781125451e-06 9.34934863781586e-06 65 155.545454545455 105 3.69974121790268e-07 16 2.84979018363599 -3.20832643683947 -1 6.86169695975223 63 105 90 306 228 61 16 190 446 150 56 50 M17595 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE.html A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. 40/42 Gene Ontology CC GO:0030140 2.92300462497611e-07 2.78404211001823e-06 95 120.272727272727 106 2.65727728485256e-08 3 1.80445551813287 -1.45542629323269 -1 4.7866499117033 92 230 193 48 3 106 53 56 151 272 119 51 M17215 GO_NEURONAL_POSTSYNAPTIC_DENSITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_POSTSYNAPTIC_DENSITY.html A postsynaptic density that is part of a neuron. 73/96 Gene Ontology CC GO:0097481 2.48628348274067e-06 6.79854579655109e-06 105 121.272727272727 108 2.26026026596892e-07 24 2.26276804556532 2.46990038852249 1 5.59044355903426 105 24 116 108 185 48 111 319 198 81 39 52 M17716 GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE.html A clathrin coat found on an endocytic vesicle. 15/17 Gene Ontology CC GO:0030128 2.64429194335676e-07 2.58214189461065e-06 55 122.636363636364 109 2.4039020556252e-08 1 1.83410515260853 -2.31975168167157 -1 4.89487546609651 197 109 222 54 1 216 156 51 23 254 66 53 M17116 GO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE.html A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. 1232/1632 Gene Ontology CC GO:0005773 8.91344658625697e-07 3.64698061029247e-06 110 167.181818181818 110 8.91345016148782e-08 3 1.77017401412797 -1.59235824669501 -1 4.59493339795012 78 135 516 300 109 3 110 109 238 218 23 54 M17060 GO_EXCITATORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. 236/315 Gene Ontology CC GO:0060076 1.56177858484308e-08 1.89040282873715e-07 40 109.090909090909 113 1.41979872357285e-09 36 2.38408781631037 2.77750216372647 1 7.67915046975188 84 184 36 91 165 40 155 163 113 52 117 55 M17213 GO_MYOSIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_FILAMENT.html A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. 12/29 Gene Ontology CC GO:0032982 2.0066739778031e-05 3.31215221904432e-05 25 141.454545454545 113 1.82426571036593e-06 25 4.1424715222479 4.95213276726611 1 8.8971085223636 166 113 89 107 372 249 186 46 25 178 25 56 M17296 GO_COSTAMERE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COSTAMERE.html Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. 28/29 Gene Ontology CC GO:0043034 1.08339334893986e-06 4.14989511278817e-06 75 112.090909090909 113 9.8490352950812e-08 7 2.49541827688435 2.63750802768436 1 6.42723085887723 154 74 129 100 113 189 253 19 7 124 71 57 M17648 GO_LAMELLAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLAR_BODY.html A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. 17/26 Gene Ontology CC GO:0042599 2.51831923107867e-06 6.79854579655109e-06 115 145.909090909091 113 2.28938373979958e-07 26 2.31988043947319 -2.4676057674555 -1 5.7326050612344 112 103 145 132 188 90 36 113 472 188 26 58 M17098 GO_EXOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE.html A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. 150/211 Gene Ontology CC GO:0070382 3.74376738502613e-07 3.23266337674013e-06 115 133.454545454545 114 3.40342547464348e-08 8 2.2613746250152 -2.09543077851048 -1 5.93865284607367 293 202 81 15 8 174 268 137 114 63 113 59 M17445 GO_LATE_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME.html A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. 238/279 Gene Ontology CC GO:0005770 5.32790828342874e-07 3.31471465533457e-06 10 123.727272727273 114 4.8435541579359e-08 6 1.65551859435582 -1.55391794324496 -1 4.32768394290143 24 187 258 226 29 6 39 114 206 263 9 60 M17408 GO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE.html The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. 747/1081 Gene Ontology CC GO:0045202 7.88787663790451e-17 3.05523755108168e-15 115 149.363636363636 115 7.88787663790455e-18 11 2.3657569339361 2.70379653188906 1 16.4986157977807 115 143 535 66 88 42 205 203 121 11 114 61 M17744 GO_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_COMPLEX.html An ion channel complex through which calcium ions pass. 56/87 Gene Ontology CC GO:0034704 2.53921589991667e-06 6.79854579655109e-06 50 138.181818181818 115 2.30838075514235e-07 46 2.50028325039182 2.79307060848607 1 6.18165530841344 48 226 115 204 193 50 46 90 296 201 51 62 M17236 GO_NUCLEAR_NUCLEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_NUCLEOSOME.html A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. 16/61 Gene Ontology CC GO:0000788 5.64667221549424e-05 8.02339928903444e-05 40 187.090909090909 116 5.13347013827116e-06 7 2.41112238337204 -2.64273923343695 -1 4.71476198007793 37 245 113 347 460 54 7 247 396 116 36 63 M17548 GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 17/20 Gene Ontology CC GO:0000780 5.66195130551484e-05 8.02339928903444e-05 25 148.818181818182 116 5.14736093413618e-06 21 2.52361883890853 2.69341928248836 1 4.93669651179895 21 298 133 222 459 45 29 65 116 162 87 64 M17302 GO_BASEMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE.html A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. 112/132 Gene Ontology CC GO:0005604 3.70532920978421e-24 2.15279627088463e-22 5 131.454545454545 117 3.36848109980383e-25 3 3.5016001257178 3.66142243422705 1 36.5031852650097 3 215 6 189 393 117 146 134 115 19 109 65 M17637 GO_LYTIC_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE.html A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. 553/770 Gene Ontology CC GO:0000323 7.94500271669352e-07 3.55843005277381e-06 225 167.181818181818 117 7.945005557233e-08 4 1.78478417261874 -1.60206910546006 -1 4.64238122183481 62 153 562 301 94 4 84 117 221 222 19 66 M17398 GO_EXTRACELLULAR_MATRIX_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_COMPONENT.html Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). 144/171 Gene Ontology CC GO:0044420 5.2617418684111e-29 4.36724575078122e-27 5 134.545454545455 119 4.78340169855558e-30 2 3.53480127864121 3.72004725260037 1 44.8399517553885 2 272 3 188 403 127 138 119 104 17 107 67 M17271 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. 22/48 Gene Ontology CC GO:0034364 1.15555727473263e-06 4.19513138275404e-06 125 161.636363636364 121 1.05050716517578e-07 16 3.63853496168979 -3.83523116088163 -1 9.38241336562012 283 84 62 16 121 224 167 309 290 121 101 68 M17437 GO_CONNEXON_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNEXON_COMPLEX.html An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. 7/20 Gene Ontology CC GO:0005922 0.000235453080771547 0.000293798054396477 75 190.909090909091 121 2.35478031661271e-05 54 3.19426436405562 3.19355563254197 1 5.39244244873372 72 121 539 200 467 154 81 120 54 100 192 69 M17821 GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX.html A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. 12/13 Gene Ontology CC GO:0036513 7.23309731665684e-05 9.93482160987618e-05 75 188 122 6.57575921392374e-06 50 1.31704919817165 -1.46802819920222 -1 2.49748580254918 75 386 304 185 421 122 61 74 50 293 97 70 M17195 GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION.html Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. 28/43 Gene Ontology CC GO:0098636 2.34148566023103e-05 3.80000885082186e-05 110 147.454545454545 123 2.12864598300668e-06 61 2.37911882237082 2.45208017080882 1 5.02358273533857 97 71 109 106 341 190 168 61 136 123 220 71 M16984 GO_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX.html A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants). 350/559 Gene Ontology CC GO:0031012 2.94379884066232e-63 8.55173563212403e-61 5 123.090909090909 124 2.67618076423849e-64 1 3.45760356584211 3.72586070750426 1 100 6 263 1 161 313 124 134 87 145 5 115 72 M17049 GO_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEMBRANE.html The lipid bilayer surrounding any membrane-bounded vesicle in the cell. 527/700 Gene Ontology CC GO:0012506 8.39112752532087e-07 3.56518231671945e-06 155 167.090909090909 126 8.39113069381851e-08 53 1.87023617097839 -1.72602650225707 -1 4.86591538877641 138 155 513 123 101 53 153 126 283 117 76 73 M17262 GO_CELL_CORTEX_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_REGION.html The complete extent of cell cortex that underlies some some region of the plasma membrane 16/25 Gene Ontology CC GO:0099738 7.7436423598222e-07 3.55843005277381e-06 460 211.545454545455 127 7.03967735041798e-08 2 2.53545827687008 -3.13759004193534 -1 6.61258769351615 458 99 127 36 73 575 478 107 2 149 223 74 M17375 GO_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_COMPLEX.html A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. 41/74 Gene Ontology CC GO:0016459 1.7279326097115e-06 5.24243919351518e-06 130 226.272727272727 127 1.57084906079326e-07 26 2.77370604905833 3.24845797939855 1 7.01306402619714 451 53 88 99 161 470 425 127 26 127 462 75 M17682 GO_LYTIC_VACUOLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_MEMBRANE.html The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. 320/391 Gene Ontology CC GO:0098852 1.25998379183335e-06 4.3993507298375e-06 275 163.818181818182 128 1.1454404667743e-07 5 1.57825074210332 -1.46213632538621 -1 4.0302777814633 26 267 360 271 128 5 45 88 273 319 20 76 M17190 GO_CLATHRIN_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE.html A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. 170/208 Gene Ontology CC GO:0030136 1.06197659246113e-06 4.14481212794304e-06 130 147.818181818182 129 9.65433731904769e-08 42 1.86773065284883 -1.63916264331739 -1 4.80048189962409 164 197 132 42 111 72 120 246 287 129 126 77 M17584 GO_SPINDLE_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MICROTUBULE.html Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. 69/78 Gene Ontology CC GO:0005876 8.06588320124682e-06 1.54662644881993e-05 100 150.181818181818 130 7.3326479758466e-07 31 2.08084267189916 1.91951535623914 1 4.77980836133391 103 31 163 286 283 130 100 100 53 206 197 78 M17620 GO_INTERMEDIATE_FILAMENT_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_CYTOSKELETON.html Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. 153/303 Gene Ontology CC GO:0045111 6.2775244613292e-07 3.47356353526882e-06 50 186.545454545455 130 5.70684204779221e-08 47 2.61586529962315 2.57886808193338 1 6.83683168273169 130 274 47 260 50 119 147 505 389 64 67 79 M17785 GO_TRANS_GOLGI_NETWORK_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_MEMBRANE.html The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. 82/97 Gene Ontology CC GO:0032588 5.56316841038888e-07 3.31471465533457e-06 135 154.545454545455 131 5.05742710650451e-08 19 1.37298100413569 -1.22713136910016 -1 3.58194721441153 131 19 314 155 36 57 83 191 230 393 91 80 M17451 GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. 66/89 Gene Ontology CC GO:0012507 1.2885436679064e-06 4.3993507298375e-06 90 157.727272727273 132 1.17140402055381e-07 32 1.69066962005863 -1.51732977038086 -1 4.32034155041418 95 32 235 210 132 86 87 59 331 315 153 81 M17224 GO_AXON_INITIAL_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_INITIAL_SEGMENT.html Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. 17/26 Gene Ontology CC GO:0043194 6.94463997862397e-06 1.39613696456074e-05 135 180.545454545455 133 6.31332900050013e-07 41 3.05409134102156 3.21836643740804 1 7.10042797569186 288 100 107 41 269 271 217 133 87 131 342 82 M17077 GO_BASAL_LAMINA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_LAMINA.html A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. 40/46 Gene Ontology CC GO:0005605 1.2803082163738e-13 3.54218606530085e-12 20 135.727272727273 134 1.16391656033988e-14 12 3.60233692295136 3.67640867906566 1 19.8273204961529 16 50 12 190 411 143 182 227 134 32 96 83 M17132 GO_MITOTIC_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE.html A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. 71/75 Gene Ontology CC GO:0072686 4.91327189754659e-06 1.06891196867066e-05 55 143.818181818182 139 4.46662079128872e-07 29 1.72867713832267 1.85421866618959 1 4.09736628834736 55 29 226 221 243 70 139 75 188 202 134 84 M17462 GO_NEURON_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION.html A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 1021/1429 Gene Ontology CC GO:0043005 8.06075926644694e-10 1.1422685692209e-08 140 171.181818181818 139 8.06075926937085e-11 5 2.29992002254092 2.63026034055776 1 8.75678485214631 182 138 541 5 79 126 297 177 139 24 175 85 M17172 GO_LIPID_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE.html An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. 70/94 Gene Ontology CC GO:0005811 1.16428248134365e-06 4.19513138275404e-06 80 158.090909090909 140 1.05843917954989e-07 28 1.94156934742674 -1.95194990286227 -1 4.98702022984344 80 284 210 328 122 28 50 140 316 143 38 86 M17263 GO_NEURON_SPINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_SPINE.html A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. 165/235 Gene Ontology CC GO:0044309 2.21571051137466e-06 6.21897491356849e-06 185 138.909090909091 140 2.01428431173729e-07 50 2.4686873580567 2.95590284629471 1 6.14902440826928 162 199 50 105 181 94 185 179 140 94 139 87 M17831 GO_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE.html A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. 517/725 Gene Ontology CC GO:0030425 1.28129880044221e-06 4.3993507298375e-06 140 184 140 1.28129953921978e-07 73 2.3614478000373 2.81429781637606 1 6.0510868714267 198 156 579 82 140 98 296 139 122 73 141 88 M17362 GO_ENDOPLASMIC_RETICULUM_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_LUMEN.html The volume enclosed by the membranes of the endoplasmic reticulum. 194/258 Gene Ontology CC GO:0005788 2.53606260090789e-10 3.98230370574996e-09 75 146.545454545455 142 2.30551145563658e-11 26 2.83342002844774 3.19014818250927 1 11.4223631848164 73 194 26 142 72 229 333 161 137 55 190 89 M17786 GO_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME.html A vacuole to which materials ingested by endocytosis are delivered. 860/1101 Gene Ontology CC GO:0005768 1.08592364522349e-06 4.14989511278817e-06 85 182.090909090909 142 1.08592417587742e-07 10 1.74615247141585 -1.61499379494511 -1 4.4848217407855 82 142 577 263 125 10 128 165 244 227 40 90 M17090 GO_MHC_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. 30/50 Gene Ontology CC GO:0042611 9.38832491575493e-06 1.73713910065402e-05 15 161.636363636364 144 8.5348772544761e-07 15 1.55251337838459 -1.4942463298471 -1 3.51783341170975 15 65 191 181 296 22 94 204 460 144 106 91 M17412 GO_CLATHRIN_COAT_OF_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_COATED_PIT.html The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. 20/22 Gene Ontology CC GO:0030132 3.6750118602633e-06 8.82306566451644e-06 145 172.090909090909 144 3.34092545385249e-07 51 1.56236286913583 -1.81931359908589 -1 3.7618343517574 144 242 270 61 221 188 122 96 51 354 144 92 M17029 GO_KINESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_COMPLEX.html Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. 51/57 Gene Ontology CC GO:0005871 3.9412453907383e-06 9.19623924505603e-06 170 125.454545454545 145 3.58295677399935e-07 21 2.06051964256515 2.43242377629647 1 4.95680290750255 81 44 168 172 286 148 145 21 90 166 59 93 M17129 GO_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. 305/423 Gene Ontology CC GO:0030139 7.16644282820587e-07 3.55558405870747e-06 145 185.636363636364 145 6.51495014787006e-08 45 1.89610041464056 -1.78713762755994 -1 4.93485730017234 309 177 141 45 64 186 350 145 349 140 136 94 M17531 GO_LAMELLIPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM.html A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. 234/281 Gene Ontology CC GO:0030027 1.17587163883134e-06 4.19513138275404e-06 75 160.818181818182 145 1.06897478847277e-07 65 2.11181521027529 2.4561003987932 1 5.42798231573923 223 181 71 85 124 200 380 220 75 65 145 95 M17709 GO_MYOSIN_II_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_II_COMPLEX.html A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. 15/31 Gene Ontology CC GO:0016460 5.24733469125494e-07 3.31471465533457e-06 150 145.363636363636 146 4.77030540256773e-08 7 2.90372625694514 3.4395941953213 1 7.62223422929044 237 107 144 127 149 228 246 7 18 190 146 96 M17139 GO_MYOFILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFILAMENT.html Any of the smallest contractile units of a myofibril (striated muscle fiber). 19/34 Gene Ontology CC GO:0036379 1.8538788025451e-07 1.95837015323401e-06 325 187.727272727273 147 1.68534450796939e-08 2 3.47333112181664 4.70497862421762 1 9.50804251345727 321 94 100 147 304 461 375 2 19 161 81 97 M17678 GO_SOMATODENDRITIC_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATODENDRITIC_COMPARTMENT.html The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. 721/1027 Gene Ontology CC GO:0036477 1.62582948769734e-07 1.74927209694843e-06 210 189.272727272727 148 1.62582960664681e-08 31 2.37338718983181 2.67290199819834 1 6.53979127940751 206 148 567 69 98 107 265 254 127 31 210 98 M17304 GO_BRUSH_BORDER http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER.html The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. 117/186 Gene Ontology CC GO:0005903 8.16371876522123e-07 3.55877147749448e-06 530 263.090909090909 149 7.42156526781843e-08 4 2.38936809726825 -2.45416767565115 -1 6.22911393926397 528 4 85 149 80 581 570 194 126 118 459 99 M17722 GO_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE.html Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. 369/538 Gene Ontology CC GO:0030133 3.65583508830981e-07 3.21824270652728e-06 240 150.272727272727 150 3.32348699619625e-08 7 2.1103148594179 -1.76536550977831 -1 5.54112361873286 239 168 67 11 7 145 233 355 150 77 201 100 M17775 GO_SYNAPSE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_PART.html Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 586/866 Gene Ontology CC GO:0044456 1.19179833722161e-11 2.38770632388192e-10 150 207.636363636364 150 1.19179833722801e-12 22 2.31229626786518 2.64468282475699 1 10.675080861885 265 150 576 67 105 150 339 268 125 22 217 101 M17009 GO_MUSCLE_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_MYOSIN_COMPLEX.html A filament of myosin found in a muscle cell of any type. 11/27 Gene Ontology CC GO:0005859 1.56510895801178e-06 4.94200165546111e-06 140 136.909090909091 151 1.42282733768364e-07 13 3.40994080898961 3.80453682101586 1 8.67344314342497 137 256 140 229 151 179 151 13 22 196 32 102 M17419 GO_CATION_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_COMPLEX.html An ion channel complex through which cations pass. 118/225 Gene Ontology CC GO:0034703 2.80258873729649e-12 6.26270790911254e-11 175 123.272727272727 151 2.54780794300004e-13 2 3.11025007563455 3.37997615685718 1 15.2441924301142 171 2 16 12 176 151 238 243 144 46 157 103 M17619 GO_CYTOPLASMIC_VESICLE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_VESICLE_PART.html Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. 589/882 Gene Ontology CC GO:0044433 7.51029452274782e-07 3.55843005277381e-06 210 194.727272727273 151 7.51029706095259e-08 82 1.99855076855167 -1.80627930384007 -1 5.20342938954319 210 151 559 121 82 100 224 166 295 91 143 104 M17828 GO_MHC_CLASS_I_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_COMPLEX.html A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. 22/39 Gene Ontology CC GO:0042612 6.86968201284438e-05 9.50306011776806e-05 250 193.363636363636 151 6.24536048520621e-06 13 1.19195073949989 -1.19195073949989 -1 2.2673609937924 13 82 247 239 400 37 66 147 498 247 151 105 M17182 GO_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON.html The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. 460/668 Gene Ontology CC GO:0030424 1.51860766719128e-11 2.94103684879377e-10 220 152.454545454545 153 1.38055242472887e-12 18 2.30350786283868 2.67834448438916 1 10.5339108531252 217 160 18 72 108 149 356 221 153 36 187 106 M17635 GO_CELL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_BODY.html The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. 535/774 Gene Ontology CC GO:0044297 8.78823047270895e-07 3.64698061029247e-06 115 193.727272727273 154 8.78823394819565e-08 40 2.39902871238938 2.62264567988126 1 6.24218115447828 235 154 561 76 107 112 252 244 111 40 239 107 M17674 GO_PRESYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPSE.html The part of a synapse that is part of the presynaptic cell. 272/414 Gene Ontology CC GO:0098793 4.72850926154403e-07 3.31471465533457e-06 445 194.909090909091 154 4.29864570713947e-08 17 2.12781268317458 -2.0374659673911 -1 5.57426868373683 445 178 53 79 17 310 452 311 110 35 154 108 M17754 GO_PROTEIN_LIPID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX.html A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. 33/64 Gene Ontology CC GO:0032994 8.40671217539699e-07 3.56518231671945e-06 85 203.090909090909 154 7.64246853436284e-08 66 3.33825910698329 -3.19062984162773 -1 8.71828120507553 336 66 83 122 84 227 209 549 269 154 135 109 M17150 GO_NEURON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PART.html Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 1276/1803 Gene Ontology CC GO:0097458 4.91946297283203e-14 1.50431999327127e-12 250 198.545454545455 156 4.91946297283215e-15 15 2.27848277278951 2.52568665897785 1 12.9335950429828 247 131 517 65 58 156 348 270 142 15 235 110 M17113 GO_T_CELL_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_COMPLEX.html A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. 10/24 Gene Ontology CC GO:0042101 2.53232177705369e-06 6.79854579655109e-06 480 217 157 2.30211335627357e-07 35 3.00955827533221 -3.29225422139861 -1 7.4493189033823 476 115 123 40 190 569 393 35 157 179 110 111 M17439 GO_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a coated vesicle. 158/202 Gene Ontology CC GO:0030662 8.09486475249854e-07 3.55877147749448e-06 230 165.090909090909 157 7.35897066453871e-08 60 1.67192544036166 -1.50434228175428 -1 4.34614055805367 132 201 229 157 78 60 93 186 361 226 93 112 M17515 GO_PHOTORECEPTOR_CONNECTING_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CONNECTING_CILIUM.html A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments. 49/62 Gene Ontology CC GO:0032391 1.66673296289684e-06 5.15091410342055e-06 205 159.363636363636 157 1.51521293238627e-07 18 1.68310330299303 1.73376010468806 1 4.2452875399498 38 48 202 288 157 18 62 466 202 204 68 113 M17176 GO_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COAT.html A membrane coat found on a coated vesicle. 51/55 Gene Ontology CC GO:0030120 5.99541371987613e-07 3.35908913643779e-06 160 163.727272727273 158 5.45037759430885e-08 46 1.43202556571382 -1.50219224782859 -1 3.73380711503394 109 228 308 158 46 170 121 85 88 328 160 114 M17358 GO_SPECIFIC_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFIC_GRANULE.html Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. 22/29 Gene Ontology CC GO:0042581 0.00020457676919229 0.000260655927413861 125 205.454545454545 158 1.85996177407772e-05 57 2.26767872541919 -2.32051909415754 -1 3.8728296813648 57 352 218 240 471 158 125 106 130 282 121 115 M17740 GO_CELL_LEADING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_LEADING_EDGE.html The area of a motile cell closest to the direction of movement. 448/544 Gene Ontology CC GO:0031252 7.14707864982635e-07 3.55558405870747e-06 60 221.818181818182 158 6.49734633788991e-08 57 2.07986850990773 2.33170668485722 1 5.41720267253034 362 158 63 74 60 352 440 339 117 57 418 116 M17091 GO_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. 467/581 Gene Ontology CC GO:0015629 6.52085147243032e-07 3.50797657915001e-06 110 251.909090909091 159 5.92804855020613e-08 51 1.92738332818937 2.21611342313268 1 5.02240220155062 425 159 106 145 51 500 528 269 108 106 374 117 M17364 GO_LATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_PLASMA_MEMBRANE.html The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. 69/93 Gene Ontology CC GO:0016328 1.17694735867282e-06 4.19513138275404e-06 375 207.636363636364 159 1.06995271664724e-07 17 2.71006888514115 -2.45950387622233 -1 6.97754824321416 374 22 44 17 255 336 493 420 95 69 159 118 M17344 GO_PHAGOCYTIC_CUP http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_CUP.html An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. 34/43 Gene Ontology CC GO:0001891 7.90475765120051e-06 1.53088806511583e-05 115 165.727272727273 160 7.18616913973097e-07 55 1.82849545799985 -2.04337041262182 -1 4.19898019890788 189 62 184 113 280 115 108 162 395 160 55 119 M17544 GO_SARCOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASM.html The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. 72/102 Gene Ontology CC GO:0016528 1.68818991170215e-06 5.18962083967698e-06 110 184.454545454545 161 1.5347192792285e-07 79 2.25865522536422 2.46805299945468 1 5.70780282804528 108 221 143 285 158 161 276 295 190 113 79 120 M17547 GO_CELL_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION.html A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. 434/593 Gene Ontology CC GO:0005911 1.05191239887995e-21 4.70123925960964e-20 235 192.181818181818 161 9.56283998981774e-23 2 2.52849989049496 2.63675240836046 1 23.4982146721076 233 161 8 2 116 240 256 530 156 12 400 121 M17277 GO_PARANODE_REGION_OF_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARANODE_REGION_OF_AXON.html An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. 18/35 Gene Ontology CC GO:0033270 1.76222345159495e-06 5.30493173770294e-06 575 273.272727272727 163 1.60202260286937e-07 8 2.97845606952805 -2.80023235526233 -1 7.52646784651721 575 88 105 34 163 552 569 382 8 152 378 122 M17662 GO_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE.html Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. 282/351 Gene Ontology CC GO:0030135 5.67916416802054e-07 3.33292361779791e-06 155 186.636363636364 163 5.16287784914748e-08 39 1.81355476405185 -1.44753374945581 -1 4.74273013730509 229 179 152 153 39 79 149 452 255 203 163 123 M17058 GO_INTERCALATED_DISC http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCALATED_DISC.html A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. 70/108 Gene Ontology CC GO:0014704 3.60070037210906e-06 8.68052662321728e-06 65 147.272727272727 164 3.27336933211273e-07 25 2.66593527863587 3.05328465595695 1 6.45770234365402 232 26 64 25 220 263 280 73 164 62 211 124 M17250 GO_NODE_OF_RANVIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NODE_OF_RANVIER.html An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. 19/32 Gene Ontology CC GO:0033268 2.61783491179821e-05 4.15563410861956e-05 105 179.181818181818 164 2.37987823871652e-06 39 3.1376618735519 3.5613863661092 1 6.5799186777828 275 91 101 39 351 231 164 206 128 103 282 125 M17285 GO_STEREOCILIUM_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEREOCILIUM_BUNDLE.html A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. 48/77 Gene Ontology CC GO:0032421 1.77431984956958e-06 5.3138135701027e-06 525 294.545454545455 164 1.61301934597833e-07 41 2.77202594158388 2.56547460770086 1 7.00094884331867 525 49 95 98 164 543 554 478 41 128 565 126 M17468 GO_FILOPODIUM_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_TIP.html The end of a filopodium distal to the body of the cell. 28/35 Gene Ontology CC GO:0032433 5.16987816832899e-07 3.31471465533457e-06 485 257.363636363636 164 4.69989034838375e-08 1 2.7710554645968 2.69945307625412 1 7.27205964694573 482 70 112 102 25 462 567 374 1 164 472 127 M17656 GO_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION.html A prolongation or process extending from a cell, e.g. a flagellum or axon. 1802/2503 Gene Ontology CC GO:0042995 1.13938729285484e-13 3.30992008574332e-12 165 210.181818181818 164 1.1393872928549e-14 16 2.15367941516822 2.4048532691481 1 11.8675785125539 214 127 564 163 66 164 295 292 161 16 250 128 M17455 GO_NUCLEAR_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE_PART.html Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. 13/16 Gene Ontology CC GO:0044453 1.36055548079005e-05 2.33870631461249e-05 205 161.818181818182 165 1.23687626818618e-06 45 1.7852189943361 -1.80364549637437 -1 3.94035499876035 205 112 205 173 321 165 79 158 89 228 45 129 M17529 GO_SEMAPHORIN_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_COMPLEX.html A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. 9/11 Gene Ontology CC GO:0002116 4.36892577760948e-05 6.37775345927414e-05 130 210.181818181818 166 4.36901167379224e-06 41 2.07567739977338 2.52734244669303 1 4.15266479547584 127 117 552 251 419 166 41 60 278 198 103 130 M17601 GO_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL.html Extracellular matrix material consisting of polysaccharides and protein. 16/23 Gene Ontology CC GO:0043205 7.60388138466643e-07 3.55843005277381e-06 175 161.818181818182 166 6.91262182982239e-08 8 3.98946842954243 4.62749103623901 1 10.4287579816101 141 297 80 166 435 214 174 8 38 175 52 131 M17108 GO_GOLGI_STACK http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_STACK.html The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. 152/184 Gene Ontology CC GO:0005795 1.15228974220185e-06 4.19513138275404e-06 170 184.818181818182 169 1.04753667794078e-07 55 1.56605770178674 -1.2760273728104 -1 4.0143892609083 169 204 240 341 120 55 143 168 300 236 57 132 M17491 GO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE.html The external part of the cell wall and/or plasma membrane. 680/1190 Gene Ontology CC GO:0009986 2.63385097887858e-23 1.39115219884405e-21 250 194 169 2.63385097887859e-24 1 2.49844491965172 2.68066097167918 1 25.0583095271666 248 147 547 1 86 134 304 169 205 7 286 133 M17721 GO_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE.html The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. 342/399 Gene Ontology CC GO:0005819 6.88575610942007e-06 1.38910565957398e-05 170 182 169 6.2597978737889e-07 47 1.68034152406244 1.80445385799103 1 3.8895231659333 58 264 278 303 268 47 78 112 169 256 169 134 M17765 GO_TERMINAL_BOUTON http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINAL_BOUTON.html Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. 63/105 Gene Ontology CC GO:0043195 1.85669750535923e-06 5.50077754121627e-06 35 283.090909090909 169 1.68790824757025e-07 31 2.2943056176724 -1.97087614979966 -1 5.77060893612246 550 34 120 31 166 517 501 493 70 169 463 135 M17085 GO_CYTOPLASMIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_REGION.html Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\ 351/475 Gene Ontology CC GO:0099568 1.14575555742544e-06 4.19513138275404e-06 85 310.545454545455 170 1.04159650375732e-07 82 2.06431258161882 -1.89030405838823 -1 5.3049434479077 553 170 82 87 118 565 580 508 99 85 569 136 M17156 GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. 12/15 Gene Ontology CC GO:0016471 2.57262008753575e-07 2.58214189461065e-06 5 136.636363636364 170 2.33874580760999e-08 3 1.28887996697912 -1.28887996697912 -1 3.42730842473826 19 252 259 236 170 12 3 4 252 291 5 137 M17142 GO_APICAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PART_OF_CELL.html The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. 410/594 Gene Ontology CC GO:0045177 2.36724341034597e-27 1.71921052676376e-25 5 223.272727272727 171 2.15203946395088e-28 3 2.64193183677624 -2.56124259609995 -1 31.473136419525 448 162 4 3 129 527 534 211 171 8 259 138 M17272 GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. 8/14 Gene Ontology CC GO:0017146 0.000138084100731587 0.000183166352796923 140 263.636363636364 171 1.38092681730527e-05 115 2.50496617842848 2.21155481783295 1 4.46734489177508 139 120 527 134 428 171 115 514 318 136 298 139 M17280 GO_AXONAL_GROWTH_CONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_GROWTH_CONE.html The migrating motile tip of a growing nerve cell axon. 37/44 Gene Ontology CC GO:0044295 2.95108413190459e-06 7.39043051998521e-06 205 151.636363636364 171 2.68280735500166e-07 47 2.28323494230661 2.48030852773472 1 5.60151688035519 99 60 135 47 209 181 201 248 112 205 171 140 M17365 GO_BANDED_COLLAGEN_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BANDED_COLLAGEN_FIBRIL.html A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). 22/23 Gene Ontology CC GO:0098643 2.12644075726698e-06 6.05618666652997e-06 115 182.090909090909 171 1.93312982964618e-07 7 4.28919493418679 4.28919493418679 1 10.7382808217754 7 291 48 195 515 114 112 252 178 171 120 141 M17606 GO_APICAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the apical end of the cell. 326/492 Gene Ontology CC GO:0016324 2.5512346150619e-26 1.64696367927885e-24 5 184.454545454545 171 2.3193041955108e-27 4 2.71904020990539 -2.64000967082387 -1 31.1076426022107 322 171 5 4 146 356 538 124 176 10 177 142 M17833 GO_ORGANELLE_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_SUBCOMPARTMENT.html A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. 349/420 Gene Ontology CC GO:0031984 7.22132390580862e-07 3.55558405870747e-06 175 193.545454545455 171 6.56484206922862e-08 41 1.49445891861587 -1.28857580231771 -1 3.88064864293619 156 172 331 343 65 41 135 171 291 332 92 143 M17453 GO_PRESYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_MEMBRANE.html A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. 53/95 Gene Ontology CC GO:0042734 1.94015401953595e-06 5.60810689229049e-06 430 241.272727272727 172 1.7637779368518e-07 29 2.26862938768219 1.76716064046713 1 5.69638839668159 428 40 99 29 172 357 505 424 154 79 367 144 M17602 GO_NONMOTILE_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM.html A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 149/208 Gene Ontology CC GO:0031513 7.1525391653007e-07 3.55558405870747e-06 160 197.363636363636 172 6.5023104460932e-08 62 2.0173112717856 2.05687980685984 1 5.25300553987879 158 207 121 199 62 73 218 567 268 126 172 145 M17008 GO_CELL_CELL_CONTACT_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_CONTACT_ZONE.html Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. 83/126 Gene Ontology CC GO:0044291 2.94898127074365e-06 7.39043051998521e-06 215 142.272727272727 173 2.68089565791028e-07 18 2.58313707423597 2.98243674491572 1 6.3427820901668 213 18 60 24 208 251 270 67 173 49 232 146 M17597 GO_INHIBITORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INHIBITORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. 9/20 Gene Ontology CC GO:0060077 1.79843539268168e-06 5.35841519563105e-06 75 244.090909090909 173 1.79843684814977e-07 71 1.727386776318 1.46618433229317 1 4.34381541567292 110 305 556 331 173 136 71 125 520 285 73 147 M17010 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX.html A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. 30/54 Gene Ontology CC GO:0005891 1.53904702612289e-06 4.88626405561422e-06 180 171.090909090909 174 1.39913463890018e-07 28 3.18030435540121 3.759993974767 1 8.09406761304 177 323 94 174 148 162 180 115 274 207 28 148 M17691 GO_PERIKARYON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIKARYON.html The portion of the cell soma (cell body) that excludes the nucleus. 120/202 Gene Ontology CC GO:0043204 8.549689781274e-07 3.57364731145338e-06 175 209.909090909091 175 7.77244827625055e-08 76 2.62385312659913 2.74653452691493 1 6.84224503012471 347 217 76 175 89 325 360 148 131 174 267 149 M17612 GO_CELL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX.html The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 298/408 Gene Ontology CC GO:0005938 9.23155799316203e-07 3.71379197833004e-06 475 276.909090909091 176 8.39232896988751e-08 61 2.18837592143009 2.28529711057797 1 5.68207787387656 472 176 61 84 102 473 517 520 85 72 484 150 M17835 GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE.html A clathrin coat found on a vesicle of the trans-Golgi network. 15/16 Gene Ontology CC GO:0030130 1.31307539299222e-05 2.27052620038239e-05 125 185.909090909091 176 1.19371202743671e-06 42 1.43367433244677 -1.44188823777603 -1 3.16503773092967 125 301 261 60 319 176 82 42 253 302 124 151 M17070 GO_SARCOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the sarcoplasmic reticulum. 31/45 Gene Ontology CC GO:0033017 5.31201444819565e-06 1.12228377978243e-05 165 176.545454545455 178 4.82911570397657e-07 68 2.08101636348255 2.31236166442584 1 4.91982739450602 163 68 147 178 251 185 197 274 285 110 84 152 M17056 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. 17/18 Gene Ontology CC GO:0012510 2.20150651761864e-06 6.209103333672e-06 150 176.090909090909 180 2.00137156421436e-07 20 1.79273702195225 -1.47637271742299 -1 4.45447653012326 148 299 214 59 180 203 116 20 310 248 140 153 M17144 GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE.html The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 142/180 Gene Ontology CC GO:0031227 9.55099302692679e-07 3.8007718826332e-06 80 200.909090909091 180 8.68272470305423e-08 25 1.49264022678893 -1.31026868111896 -1 3.85505263950962 77 278 343 358 106 25 51 180 350 379 63 154 M17559 GO_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_COMPLEX.html Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 265/450 Gene Ontology CC GO:0043235 9.08157447642132e-13 2.29408468295686e-11 180 190.181818181818 180 8.25597679675008e-14 18 2.27535441595686 2.38742951972053 1 11.6189088280954 178 180 20 247 145 180 247 315 242 18 320 155 M17845 GO_COLLAGEN_TRIMER http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_TRIMER.html A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. 58/89 Gene Ontology CC GO:0005581 1.85416742705001e-13 4.89668761416389e-12 15 178.909090909091 181 1.68560675186378e-14 12 4.14400276816723 4.16603355483048 1 22.5342485048443 12 285 13 191 446 178 169 224 181 75 194 156 M17685 GO_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_CILIUM.html A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors. 233/307 Gene Ontology CC GO:0072372 8.87693981728953e-07 3.64698061029247e-06 185 212.727272727273 182 8.0699485446477e-08 66 1.8718958783473 1.92376698279273 1 4.86138781593954 157 190 181 340 96 66 215 434 315 182 164 157 M17763 GO_AXON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_PART.html A part of an axon, a cell projection of a neuron. 248/371 Gene Ontology CC GO:0033267 1.6074429110681e-06 5.02109855554068e-06 270 201.636363636364 182 1.46131280505173e-07 22 2.30133816520057 2.67483666292236 1 5.83235122464094 300 182 45 22 167 269 377 366 163 58 269 158 M17257 GO_DENDRITIC_SHAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SHAFT.html Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. 47/67 Gene Ontology CC GO:0043198 4.96740501791875e-06 1.06891196867066e-05 190 178.818181818182 183 4.51583293992225e-07 39 2.52035632003591 2.93713399114805 1 5.99303375727527 188 41 69 92 247 199 352 467 39 90 183 159 M17655 GO_ACTIN_BASED_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BASED_CELL_PROJECTION.html A cell projection supported by an assembly of actin filaments, and which lacks microtubules. 227/302 Gene Ontology CC GO:0098858 2.65982094333192e-12 6.18142387230339e-11 405 215.909090909091 183 2.41801903939557e-13 7 2.54039700179751 2.72037604812361 1 12.4504453503227 361 183 15 7 100 327 402 483 67 28 402 160 M17568 GO_PRESYNAPTIC_ACTIVE_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_ACTIVE_ZONE.html A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. 21/44 Gene Ontology CC GO:0048786 2.41207355180198e-06 6.64177598861115e-06 415 255.909090909091 184 2.19279654217856e-07 23 2.67439450870252 -2.68624458479643 -1 6.62809689480402 558 80 91 23 184 509 411 340 101 104 414 161 M17605 GO_MICROTUBULE_ASSOCIATED_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ASSOCIATED_COMPLEX.html Any multimeric complex connected to a microtubule. 143/174 Gene Ontology CC GO:0005875 2.5011840321886e-06 6.79854579655109e-06 160 209.727272727273 186 2.27380625072167e-07 102 1.77621628231576 1.91741362488169 1 4.3793416452666 149 312 242 344 186 159 199 102 166 290 158 162 M17686 GO_RUFFLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE.html Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. 232/276 Gene Ontology CC GO:0001726 7.02017529113867e-07 3.55558405870747e-06 500 319.545454545455 186 6.38197957388158e-08 56 1.96095379219057 2.0678936840014 1 5.1050812255907 497 186 137 97 56 530 545 566 177 153 571 163 M17084 GO_NEURON_PROJECTION_TERMINUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_TERMINUS.html The specialized, terminal region of a neuron projection such as an axon or a dendrite. 136/226 Gene Ontology CC GO:0044306 2.57815857417625e-06 6.84096788648375e-06 170 182 187 2.34378326863648e-07 26 2.47961036875456 2.94776399124217 1 6.12697065352876 203 214 68 26 194 187 293 370 170 107 170 164 M17270 GO_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an endocytic vesicle. 162/230 Gene Ontology CC GO:0030666 2.14999373244635e-06 6.09339687098211e-06 180 201.818181818182 187 1.95454166688485e-07 43 1.81136446081802 -1.62006746617121 -1 4.50832437963496 259 273 179 187 179 91 289 174 353 193 43 165 M17782 GO_PHOTORECEPTOR_DISC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_DISC_MEMBRANE.html Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment. 19/33 Gene Ontology CC GO:0097381 1.8651517652661e-06 5.50077754121627e-06 190 286.909090909091 187 1.69559395139697e-07 16 1.85371106854099 -1.91508873084693 -1 4.6543782815791 526 101 187 53 168 566 578 16 475 186 300 166 M17052 GO_AUTOPHAGOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME.html A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. 78/88 Gene Ontology CC GO:0005776 8.90584860265234e-06 1.67453010943075e-05 30 194.727272727273 189 8.09625877703469e-07 27 1.27862095699076 -1.17461559516085 -1 2.89964235042799 64 28 366 359 292 27 89 189 271 375 82 167 M17141 GO_CELL_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a cell surface projection. 333/464 Gene Ontology CC GO:0031253 6.97042761768907e-10 1.01245461146934e-08 320 202.727272727273 191 6.33675238172504e-11 13 2.33778884998202 2.59159420385704 1 8.96065655458158 317 174 31 13 52 258 332 513 191 23 326 168 M17777 GO_EARLY_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME.html A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. 351/455 Gene Ontology CC GO:0005769 2.53242487462476e-06 6.79854579655109e-06 255 192.636363636364 191 2.30220708155395e-07 52 1.71544350518744 -1.45437066094799 -1 4.22806888819444 155 175 252 182 191 52 251 285 250 252 74 169 M17513 GO_TRANSPORTER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_COMPLEX.html A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. 208/394 Gene Ontology CC GO:1990351 1.0526726581397e-14 3.39779341321758e-13 270 210 192 9.56975143763367e-16 10 2.79907460200021 2.99231917747244 1 16.7694459170368 269 192 11 10 174 267 397 492 185 26 287 170 M17599 GO_SUPRAMOLECULAR_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPRAMOLECULAR_FIBER.html A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. 562/821 Gene Ontology CC GO:0099512 1.53824655909636e-06 4.88626405561422e-06 195 217.272727272727 192 1.53824762388851e-07 59 2.04699030671197 2.18819670922259 1 5.19477160820402 201 152 557 192 159 147 286 181 261 59 195 171 M17197 GO_TRANS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. 208/247 Gene Ontology CC GO:0005802 5.31113024982074e-07 3.31471465533457e-06 350 200.363636363636 193 4.82830139273431e-08 27 1.44276498388243 -1.26920835347279 -1 3.76613678266258 143 193 346 255 27 65 131 290 267 349 138 172 M17403 GO_GOLGI_ASSOCIATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE.html Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. 98/113 Gene Ontology CC GO:0005798 2.66658371216246e-07 2.58214189461065e-06 155 192.636363636364 193 2.42416730488611e-08 2 1.53507007817192 -1.17511398574023 -1 4.08997130719075 153 218 297 136 2 108 85 333 193 381 213 173 M17733 GO_GOLGI_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LUMEN.html The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. 58/156 Gene Ontology CC GO:0005796 2.2090846677589e-10 3.56521719991089e-09 540 273.727272727273 193 2.00825878907338e-11 25 3.442152620663 -3.28725945534429 -1 13.9650211240187 538 36 25 193 154 555 533 425 138 68 346 174 M17771 GO_RECYCLING_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME.html An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. 147/172 Gene Ontology CC GO:0055037 1.45014626670466e-06 4.73334258963712e-06 205 188.363636363636 193 1.31831565689107e-07 143 1.77001094417199 -1.61698012763378 -1 4.49796369789041 204 209 206 201 143 163 193 185 165 255 148 175 M17827 GO_ANCHORED_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 98/186 Gene Ontology CC GO:0031225 3.58280207430082e-22 1.73467333764064e-20 10 190.727272727273 193 3.25709279481891e-23 7 3.44666065998805 3.37796841628623 1 32.7650851415662 297 9 7 116 202 242 389 193 152 13 478 176 M17229 GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM.html The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. 14/22 Gene Ontology CC GO:0097038 2.99839858217326e-05 4.65794004342958e-05 210 195.545454545455 194 2.72585404398232e-06 48 2.17251933969944 -2.41323596406316 -1 4.49118228863326 208 247 173 207 358 194 243 110 48 177 186 177 M17310 GO_COMPLEX_OF_COLLAGEN_TRIMERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEX_OF_COLLAGEN_TRIMERS.html A complex of collagen trimers such as a fibril or collagen network. 28/30 Gene Ontology CC GO:0098644 1.22412373683726e-08 1.54612150239662e-07 15 199.090909090909 194 1.1128397669532e-09 14 4.30387353168938 4.29954449331401 1 14.0775549269054 14 290 34 194 498 184 204 329 119 125 199 178 M17055 GO_ZYMOGEN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_GRANULE.html A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. 21/28 Gene Ontology CC GO:0042588 2.72216097301048e-06 7.15645034081035e-06 175 219.363636363636 195 2.47469485570093e-07 128 2.67185751818927 -2.36642256712065 -1 6.58005357110078 128 327 174 292 199 195 136 176 218 394 174 179 M17334 GO_LEADING_EDGE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEADING_EDGE_MEMBRANE.html The portion of the plasma membrane surrounding the leading edge of a motile cell. 184/233 Gene Ontology CC GO:0031256 5.16797816626027e-07 3.31471465533457e-06 215 172.727272727273 195 4.69816307296418e-08 24 2.19546933036296 2.3927209176144 1 5.75284331763084 211 195 70 96 24 226 334 266 183 47 248 180 M17647 GO_MAIN_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAIN_AXON.html The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. 68/108 Gene Ontology CC GO:0044304 1.42065931689262e-06 4.66329414189048e-06 280 186.090909090909 197 1.2915093039002e-07 27 2.38385008402353 2.41680543217096 1 6.07983334543049 279 27 72 35 197 241 284 367 146 39 360 181 M17067 GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 274/347 Gene Ontology CC GO:0031300 8.52221766155623e-07 3.57364731145338e-06 120 225 198 7.74747360258143e-08 87 1.58191974751583 -1.3772623917083 -1 4.10853454610343 117 269 352 417 87 96 127 198 282 362 168 182 M17446 GO_VACUOLAR_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_LUMEN.html The volume enclosed within the vacuolar membrane. 116/197 Gene Ontology CC GO:0005775 5.59108496080529e-07 3.31471465533457e-06 435 208.909090909091 198 5.08280580156854e-08 6 2.18747955591776 -2.1858746128089 -1 5.73175490864607 431 6 125 170 37 239 386 361 120 225 198 183 M17174 GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE.html The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 14/16 Gene Ontology CC GO:0031231 0.000242114698580834 0.000301217644272943 115 189.727272727273 200 2.20128498115033e-05 12 1.93270356818747 -0.983093536348969 -1 3.23607592008738 113 246 200 225 456 133 42 118 12 280 262 184 M17350 GO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON.html Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. 1838/2385 Gene Ontology CC GO:0005856 1.21413036557662e-06 4.30127891707327e-06 200 247.363636363636 200 1.21413102892778e-07 112 1.80430754362351 1.99857284621333 1 4.62206014522616 200 128 530 499 136 169 277 208 266 112 196 185 M17664 GO_CELL_PROJECTION_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_PART.html Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. 1003/1408 Gene Ontology CC GO:0044463 7.32550582223904e-12 1.57634032693366e-10 290 227.454545454545 201 7.32550582226317e-13 6 2.19773101694117 2.42238119180094 1 10.3349959573825 289 139 565 6 59 201 383 388 155 21 296 186 M17255 GO_MICROVILLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS.html Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. 91/118 Gene Ontology CC GO:0005902 7.90749005163783e-07 3.55843005277381e-06 445 229.181818181818 204 7.18862990349019e-08 14 2.62267636099421 -2.62367441213673 -1 6.8414987919753 441 14 42 119 204 483 474 250 148 56 290 187 M17347 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. 14/16 Gene Ontology CC GO:0033178 2.86394334377127e-06 7.28832635594392e-06 70 225.909090909091 205 2.60358824730712e-07 49 1.31276880400077 -1.31276880400077 -1 3.20664564425101 66 383 305 364 205 104 70 49 419 358 162 188 M17105 GO_CELL_CORTEX_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_PART.html Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 143/185 Gene Ontology CC GO:0044448 1.14665622634507e-06 4.19513138275404e-06 95 302.727272727273 206 1.04241529453745e-07 75 2.31036161444977 -2.20180648775185 -1 5.942247009559 568 206 75 94 119 544 564 387 102 92 579 189 M17160 GO_MICROBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY.html Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 142/169 Gene Ontology CC GO:0042579 2.91519944266277e-06 7.36404728776986e-06 55 205.181818181818 207 2.65018482324861e-07 51 1.63915566198969 -1.54106115552615 -1 4.01077864749494 51 367 320 419 207 51 63 62 222 365 130 190 M17348 GO_CYTOSKELETAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PART.html Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. 1329/1737 Gene Ontology CC GO:0044430 1.28209248169819e-06 4.3993507298375e-06 175 231.090909090909 207 1.2820932213913e-07 96 1.79934178079029 1.9372295187771 1 4.60073802025259 173 258 529 339 142 105 244 207 246 96 203 191 M17341 GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS.html A cell part consisting of multiple, closely packed actin-based cell projections. 149/238 Gene Ontology CC GO:0098862 5.3010645522023e-07 3.31471465533457e-06 520 264 208 4.81915075412172e-08 26 2.54423765827089 2.46734019085496 1 6.67339109908645 519 208 54 146 26 446 495 262 105 87 556 192 M17503 GO_SPERM_MIDPIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MIDPIECE.html The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. 12/16 Gene Ontology CC GO:0097225 2.71459245336249e-06 7.15645034081035e-06 475 241.272727272727 208 2.46781436629025e-07 49 1.94567678287273 1.44568833429339 1 4.78027233596445 475 114 208 180 198 427 399 82 49 242 280 193 M17549 GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX.html A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. 17/20 Gene Ontology CC GO:0005942 2.49341329779888e-05 4.01294494742701e-05 240 215.818181818182 208 2.26676505257966e-06 13 1.66796960235898 -2.10334684015906 -1 3.49041066747241 240 110 223 184 344 208 172 240 13 459 181 194 M17582 GO_RECYCLING_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a recycling endosome. 47/51 Gene Ontology CC GO:0055038 7.63636423177119e-07 3.55843005277381e-06 535 290.363636363636 208 6.94215171128318e-08 51 1.79174784526343 -1.67581813373495 -1 4.66065795848195 495 51 203 154 71 531 481 535 132 208 333 195 M17051 GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the cytoplasm. 14/16 Gene Ontology CC GO:0000153 3.57281973896357e-07 3.21824270652728e-06 400 251.363636363636 209 3.24801847199348e-08 5 0.947226672038852 -0.947226672038852 -1 2.46405334723856 121 480 396 399 5 152 15 209 466 397 125 196 M17540 GO_CHROMOCENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOCENTER.html A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure. 13/17 Gene Ontology CC GO:0010369 1.57172269836729e-05 2.64687213840985e-05 30 186.636363636364 209 1.42884902470146e-06 12 1.80070551828884 1.80070551828884 1 3.92827308287128 30 333 209 329 441 34 12 44 262 260 99 197 M17697 GO_MICROBODY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_PART.html Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 98/112 Gene Ontology CC GO:0044438 5.42716540875385e-06 1.1342385260741e-05 370 206.181818181818 209 4.93379890639858e-07 40 1.45751362408842 -1.3244382829224 -1 3.42998121457518 40 369 334 351 253 67 44 79 209 367 155 198 M16985 GO_PHAGOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. 134/188 Gene Ontology CC GO:0045335 3.00026573705571e-06 7.48134932716467e-06 85 195.727272727273 210 2.72751802608853e-07 37 1.61811977736726 -1.5737914903859 -1 3.95341923269502 83 216 249 365 210 43 142 58 430 320 37 199 M17499 GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 113/125 Gene Ontology CC GO:0000779 1.14010797978707e-05 2.02016391723283e-05 5 191.090909090909 210 1.03646717111071e-06 5 1.69949995931267 1.67692515727546 1 3.80119719103032 5 342 267 348 401 21 17 122 236 210 133 200 M17671 GO_KERATIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATIN_FILAMENT.html A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. 27/107 Gene Ontology CC GO:0045095 3.45602788701369e-10 5.28408474303935e-09 80 229.181818181818 210 3.14184353414236e-11 27 4.38894835865575 -4.10547227240368 -1 17.4564980625183 325 237 27 164 345 210 77 461 426 76 173 201 M17719 GO_EXTRINSIC_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 257/326 Gene Ontology CC GO:0019898 3.01565423042856e-06 7.48758593110681e-06 290 223.545454545455 211 2.74150760377302e-07 174 1.92135690574267 -1.94073419883196 -1 4.70181696480877 287 270 178 218 211 193 285 238 174 199 206 202 M17311 GO_EARLY_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding an early endosome. 144/194 Gene Ontology CC GO:0031901 1.73244117926836e-06 5.24243919351518e-06 245 193.090909090909 212 1.57494776683724e-07 51 1.7290782155482 -1.30959711271762 -1 4.3560246529087 245 210 225 51 162 153 307 241 240 212 78 203 M17371 GO_INTRACELLULAR_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_VESICLE.html Any vesicle that is part of the intracellular region. 1266/1799 Gene Ontology CC GO:0097708 6.77184187240102e-07 3.55558405870747e-06 355 249.636363636364 214 6.77184393600481e-08 41 2.04812979959586 -1.78583394703385 -1 5.33389648153301 353 132 532 214 68 177 364 394 264 41 207 204 M17076 GO_MICROBODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_MEMBRANE.html The lipid bilayer surrounding a microbody. 64/69 Gene Ontology CC GO:0031903 1.21676987086697e-05 2.1293472740172e-05 425 244.818181818182 215 1.10616054599635e-06 60 1.49375913653191 -1.12244581158316 -1 3.3195010978199 124 425 340 424 315 99 60 94 215 408 189 205 M17166 GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 1096/2062 Gene Ontology CC GO:0031226 9.46469021948572e-71 5.4989850175212e-68 305 241.545454545455 215 9.46469021948593e-72 1 2.62453842223325 2.76037915904666 1 84.9880458639803 303 134 519 62 67 215 374 398 194 1 390 206 M17659 GO_CILIARY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_MEMBRANE.html The portion of the plasma membrane surrounding a cilium. 66/102 Gene Ontology CC GO:0060170 1.09282952195627e-06 4.14989511278817e-06 510 281.181818181818 215 9.93481877099579e-08 35 2.0772519030408 2.18058283654805 1 5.34316940631276 508 35 156 131 114 426 468 215 376 146 518 207 M16981 GO_MULTIVESICULAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY.html A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 37/51 Gene Ontology CC GO:0005771 3.19647614841208e-06 7.80316236230008e-06 315 199.727272727273 216 2.90589162974675e-07 56 2.60882870718379 -2.52024238180088 -1 6.37662609357263 315 56 96 126 216 243 249 402 71 165 258 208 M17145 GO_SPINDLE_POLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_POLE.html Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. 146/171 Gene Ontology CC GO:0000922 1.14218220529112e-05 2.02016391723283e-05 310 203.727272727273 216 1.03835285022198e-06 49 1.58751568588489 1.74276850054251 1 3.5479638022568 49 341 294 309 309 58 67 141 216 279 178 209 M17158 GO_APICAL_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_COMPLEX.html A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. 136/174 Gene Ontology CC GO:0043296 3.72751490918148e-06 8.83953535605893e-06 220 246.636363636364 217 3.38865565892546e-07 73 2.35775018414638 -2.61086372927799 -1 5.69738414974383 399 212 73 144 223 528 503 217 97 98 219 210 M17349 GO_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE.html Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. 403/498 Gene Ontology CC GO:0005874 3.33275104818364e-06 8.10179229704894e-06 170 205.818181818182 217 3.02977826994096e-07 132 1.79723854285729 1.89747979439729 1 4.36573280123203 209 166 217 264 217 132 231 263 168 173 224 211 M17518 GO_CLATHRIN_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated vesicle. 80/104 Gene Ontology CC GO:0030665 8.29447455552915e-07 3.56518231671945e-06 330 222 217 7.54043425702419e-08 23 1.79736241776336 -1.67286004945075 -1 4.67468107703263 329 23 165 137 83 217 260 423 418 119 268 212 M17035 GO_BASOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASOLATERAL_PLASMA_MEMBRANE.html The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 220/324 Gene Ontology CC GO:0016323 9.45590897187024e-17 3.43367694541038e-15 525 276 218 8.59628088351839e-18 9 2.69058072208434 2.41653574468504 1 18.7039439192781 524 188 9 143 218 492 516 389 129 20 408 213 M17813 GO_CENTRIOLAR_SATELLITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLAR_SATELLITE.html A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. 30/33 Gene Ontology CC GO:0034451 2.81612216594122e-06 7.22391092651984e-06 220 215.181818181818 218 2.56011433703676e-07 18 1.59819840910553 -1.56698808107982 -1 3.91593796276038 218 373 268 277 305 191 202 18 135 339 41 214 M17235 GO_GOLGI_CISTERNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA.html Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. 115/145 Gene Ontology CC GO:0031985 1.52959765767182e-06 4.88626405561422e-06 275 199.818181818182 219 1.39054429196252e-07 3 1.59868298206186 -1.27377830141747 -1 4.04789123837178 271 3 224 342 147 89 157 314 305 219 127 215 M17007 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE.html A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. 32/33 Gene Ontology CC GO:0000407 3.701270156291e-06 8.83953535605893e-06 80 212.818181818182 222 3.36479671209638e-07 52 1.11285516317836 -1.23862822107088 -1 2.66701761634036 76 235 370 320 222 85 52 219 277 421 64 216 M17251 GO_COMPACT_MYELIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPACT_MYELIN.html The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. 23/26 Gene Ontology CC GO:0043218 1.30238954480559e-06 4.3993507298375e-06 430 257.181818181818 222 1.18399119619514e-07 20 2.27910783494807 -2.28640556657197 -1 5.83863286865181 429 86 175 104 134 474 487 440 20 258 222 217 M17608 GO_PHAGOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a phagocytic vesicle. 74/111 Gene Ontology CC GO:0030670 8.65357795911452e-06 1.63769667565001e-05 280 181.181818181818 222 7.86691999788258e-07 16 1.44052300931328 -1.50113732963192 -1 3.27881419552047 34 222 277 280 289 16 74 47 375 352 27 218 M17732 GO_SPERM_FLAGELLUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_FLAGELLUM.html A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. 52/88 Gene Ontology CC GO:0036126 1.93173678292795e-06 5.60810689229049e-06 175 238.545454545455 222 1.75612589010457e-07 31 1.51473741866431 1.49755956240092 1 3.78947738477506 172 288 266 448 171 222 214 31 314 346 152 219 M17746 GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. 15/34 Gene Ontology CC GO:0034361 6.01282736987143e-07 3.35908913643779e-06 460 255.272727272727 223 5.46620819385448e-08 35 3.35645622885348 3.55854616350525 1 8.80784356119506 459 249 138 223 47 570 535 45 35 191 316 220 M17592 GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX.html A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. 4/20 Gene Ontology CC GO:0005892 5.41964805285837e-06 1.1342385260741e-05 260 218.363636363636 224 5.419661270567e-07 33 2.07200873922014 -2.50306496400483 -1 4.89375777534369 258 125 555 129 261 256 392 40 33 224 129 221 M17802 GO_MICROBODY_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_LUMEN.html The volume enclosed by the membranes of a microbody. 43/53 Gene Ontology CC GO:0031907 3.81684415857126e-06 9.01457908995895e-06 30 190.909090909091 224 3.46986434594689e-07 24 1.38618713778758 -1.52240426205939 -1 3.32668556219033 31 289 291 478 224 29 24 29 317 305 83 222 M17840 GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE.html A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood. 15/34 Gene Ontology CC GO:0034385 6.01282736987143e-07 3.35908913643779e-06 40 255.636363636364 224 5.46620819385448e-08 36 3.35645622885348 3.55854616350525 1 8.80784356119506 460 250 139 224 48 571 536 39 36 192 317 223 M17320 GO_PLATELET_ALPHA_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet alpha granule. 51/92 Gene Ontology CC GO:0031093 1.89034266896881e-06 5.54691459934789e-06 250 232.181818181818 225 1.71849481203764e-07 47 3.12479837171969 3.53516617134443 1 7.86917299929053 249 47 56 217 169 314 271 456 225 138 412 224 M17201 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX.html A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. 32/56 Gene Ontology CC GO:0008328 3.03200248955694e-05 4.68508895327815e-05 180 230 226 2.75640388809506e-06 59 2.3455869611428 2.64713912023793 1 4.84944847026594 226 59 102 176 360 234 178 559 280 71 285 225 M17111 GO_CD40_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD40_RECEPTOR_COMPLEX.html A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. 15/16 Gene Ontology CC GO:0035631 0.00101980726789226 0.0011873908269447 280 251.818181818182 227 9.27527550272337e-05 21 2.37536231204584 -2.84544109775017 -1 3.30525543293598 276 300 172 227 488 268 176 503 21 223 116 226 M17012 GO_IMMUNOLOGICAL_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE.html An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 36/68 Gene Ontology CC GO:0001772 6.42173219431669e-06 1.30913207189403e-05 505 270.181818181818 229 5.83795539930149e-07 58 2.64594281264991 2.98364155051429 1 6.18153915439914 503 58 119 112 264 443 464 229 98 157 525 227 M17764 GO_BRUSH_BORDER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER_MEMBRANE.html The portion of the plasma membrane surrounding the brush border. 60/96 Gene Ontology CC GO:0031526 1.36750189307903e-06 4.55874138450338e-06 365 273.272727272727 230 1.24318431191608e-07 98 2.66951805352396 -2.42681120842127 -1 6.8260964527497 365 286 98 230 137 457 556 188 210 155 324 228 M17737 GO_COHESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_COHESIN_COMPLEX.html A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). 10/14 Gene Ontology CC GO:0008278 8.78137519261035e-06 1.65648668406059e-05 60 216.545454545455 232 7.98310022178676e-07 56 1.66534104083265 1.66534104083265 1 3.79309872395725 60 336 232 352 291 118 56 354 208 253 122 229 M17313 GO_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 264/357 Gene Ontology CC GO:0005667 4.27850603001843e-06 9.74828236643415e-06 130 280.909090909091 233 3.88955850070423e-07 126 1.51680587921793 1.66128770130439 1 3.61927787087249 142 366 393 479 233 129 126 195 360 451 216 230 M17810 GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the plasma membrane. 405/687 Gene Ontology CC GO:0098797 2.74476336867588e-16 9.38063245412167e-15 475 269.090909090909 233 2.49523942606898e-17 10 2.37676628503558 2.67122223533971 1 16.0178306019055 471 165 10 71 131 521 561 350 233 14 433 231 M17239 GO_GOLGI_APPARATUS_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS_PART.html Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. 903/1202 Gene Ontology CC GO:0044431 4.45816191059435e-07 3.31471465533457e-06 320 238.090909090909 234 4.45816280497893e-08 18 1.86394031164197 -1.56124999118282 -1 4.87779739674 316 141 522 246 18 140 234 379 224 159 240 232 M17353 GO_COPI_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE.html A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. 30/32 Gene Ontology CC GO:0030137 7.5009559959266e-07 3.55843005277381e-06 70 234.363636363636 234 6.81905323036169e-08 69 0.956626485863224 -0.814621920294142 -1 2.46881265888877 151 234 403 257 69 146 102 360 69 493 294 233 M17438 GO_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the Golgi apparatus. 761/943 Gene Ontology CC GO:0000139 4.54248023595572e-07 3.31471465533457e-06 335 241.909090909091 234 4.54248116449169e-08 20 1.79716170946591 -1.48186416826696 -1 4.70154029664543 332 144 540 283 20 157 227 305 234 181 238 234 M17574 GO_CILIARY_BASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASE.html Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. 22/25 Gene Ontology CC GO:0097546 2.32274316376232e-05 3.78015063906417e-05 220 247.272727272727 234 2.11160698860852e-06 90 1.36863799479739 1.44119982304683 1 2.87361131932277 219 90 273 234 340 300 321 230 180 372 161 235 M16998 GO_ER_TO_GOLGI_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE.html A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. 97/130 Gene Ontology CC GO:0030134 9.01425365849604e-07 3.66243452838196e-06 420 263.818181818182 235 8.19477941089788e-08 11 2.08377366708843 -1.45408469247772 -1 5.41454591930876 416 11 128 150 97 347 317 555 201 235 445 236 M17097 GO_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_PIT.html A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. 81/85 Gene Ontology CC GO:0005905 1.10978057358853e-06 4.18689943672038e-06 115 280.272727272727 235 1.00889193946635e-07 21 1.85274347151107 -1.73287230955926 -1 4.75770929504025 513 21 188 115 115 476 496 342 235 216 366 237 M17734 GO_ESCRT_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_III_COMPLEX.html An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. 12/12 Gene Ontology CC GO:0000815 4.40271900957462e-06 9.95322857806558e-06 35 163 235 4.00247983679882e-07 4 0.959922545891218 -0.959922545891218 -1 2.27091513847456 35 255 321 238 235 31 4 26 342 292 14 238 M17205 GO_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_COMPLEX.html An ion channel complex through which sodium ions pass. 8/17 Gene Ontology CC GO:0034706 4.05955892140484e-05 5.98630389171627e-05 120 233.454545454545 236 4.05963308339545e-06 21 4.52166233164954 4.47565264327766 1 9.15550738890421 268 116 520 21 381 236 119 332 52 135 388 239 M17560 GO_INTRACILIARY_TRANSPORT_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE.html A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. 35/39 Gene Ontology CC GO:0030990 4.47171403542584e-06 1.00622212585881e-05 170 244.727272727273 236 4.06520284058684e-07 132 1.34216524973183 1.47065200063677 1 3.18883708152045 167 232 309 274 236 221 458 132 245 251 167 240 M17005 GO_LYSOSOMAL_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_LUMEN.html The volume enclosed within the lysosomal membrane. 93/120 Gene Ontology CC GO:0043202 4.34727523773074e-07 3.31471465533457e-06 220 305.090909090909 239 3.95206917887948e-08 11 2.05730860256102 2.28936268728286 1 5.38817846338427 540 219 154 304 11 478 515 218 179 239 499 241 M17472 GO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE.html A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 140/151 Gene Ontology CC GO:0000776 3.27857982030562e-05 4.97351142453673e-05 10 204.909090909091 241 2.98057152800474e-06 10 1.6494566545481 1.65576000542121 1 3.37715563350671 10 392 319 355 367 19 28 143 241 249 131 242 M17168 GO_LUMENAL_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUMENAL_SIDE_OF_MEMBRANE.html Any side (leaflet) of a membrane that faces the lumen of an organelle. 43/66 Gene Ontology CC GO:0098576 2.56403006383297e-05 4.09258644804108e-05 90 227.363636363636 243 2.33096358843261e-06 35 1.44117970864778 -1.35240298402714 -1 3.0042015097439 88 320 275 243 348 35 58 297 514 234 89 243 M17519 GO_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of a membrane. 882/1255 Gene Ontology CC GO:0098796 7.89984012516655e-07 3.55843005277381e-06 175 258.545454545455 243 7.89984293350428e-08 92 1.86969311500988 -1.60266406134333 -1 4.86523178622118 236 260 550 266 92 172 175 368 243 194 288 244 M17642 GO_NUCLEAR_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PERIPHERY.html The portion of the nuclear lumen proximal to the inner nuclear membrane. 137/182 Gene Ontology CC GO:0034399 1.37217384957897e-05 2.3517197834967e-05 245 248.909090909091 244 1.24743855283011e-06 103 1.80103068869111 1.94662781280225 1 3.97353549422275 146 368 262 313 322 244 181 103 123 435 241 245 M17675 GO_A_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_A_BAND.html The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. 45/72 Gene Ontology CC GO:0031672 5.52936972318202e-07 3.31471465533457e-06 545 304.636363636364 244 5.02670101173326e-08 33 1.7528802924397 1.93015602275527 1 4.58466282543783 544 52 189 46 33 533 543 531 60 244 576 246 M17460 GO_COP9_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_COP9_SIGNALOSOME.html A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. 43/56 Gene Ontology CC GO:0008180 2.76848649457622e-06 7.20585696891978e-06 255 259.181818181818 246 2.51680907132176e-07 118 1.88491103422522 1.60510981443777 1 4.62695636896062 246 397 254 156 200 252 118 347 232 404 245 247 M17088 GO_SECRETORY_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_LUMEN.html The volume enclosed by the membrane of a secretory granule. 65/169 Gene Ontology CC GO:0034774 9.26849977380132e-07 3.71379197833004e-06 360 279.727272727273 248 8.42591243507304e-08 46 3.16365867767454 3.36302629073037 1 8.2330696736151 359 223 46 120 103 408 366 574 248 108 522 248 M17603 GO_NUCLEAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MATRIX.html The dense fibrillar network lying on the inner side of the nuclear membrane. 114/158 Gene Ontology CC GO:0016363 5.0881141514587e-06 1.08285506300275e-05 200 242.454545454545 249 4.62556901743743e-07 106 1.93312557045095 2.12360332011804 1 4.58167497617842 199 313 221 308 249 295 229 111 106 376 260 249 M17397 GO_CELL_DIVISION_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION_SITE.html The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. 66/80 Gene Ontology CC GO:0032153 1.5921906719871e-06 5.00033935364596e-06 360 213.181818181818 250 1.44744711299393e-07 33 1.5753820028691 1.98144377309628 1 3.98067609915421 358 33 250 186 153 306 340 273 93 267 86 250 M17760 GO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM.html A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. 473/685 Gene Ontology CC GO:0005929 1.26463256472854e-06 4.3993507298375e-06 255 268.909090909091 251 1.14966662880149e-07 125 1.74945384167738 1.82529178574185 1 4.47201690234536 253 164 251 542 130 125 299 390 321 237 246 251 M17186 GO_BASAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 43/58 Gene Ontology CC GO:0009925 2.82517051798867e-05 4.41327290938812e-05 545 303.909090909091 252 2.5683698168986e-06 78 2.9049205452372 -3.77671342568782 -1 6.05217819836952 545 229 78 151 355 559 562 257 175 180 252 252 M17418 GO_CELL_TRAILING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_TRAILING_EDGE.html The area of a motile cell opposite to the direction of movement. 14/27 Gene Ontology CC GO:0031254 1.3223887509226e-05 2.2798452946173e-05 520 282.636363636364 253 1.20217881789131e-06 78 2.7388492201697 -2.10864051668331 -1 6.08222257730367 520 108 151 114 320 420 405 253 78 209 531 253 M17521 GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. 12/14 Gene Ontology CC GO:0031235 5.07920463454929e-06 1.08285506300275e-05 390 289.181818181818 253 4.61746941917833e-07 149 2.09421050424379 1.79174509893127 1 4.96695443463487 388 253 199 268 248 280 236 564 149 211 385 254 M17306 GO_PLATELET_DENSE_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_TUBULAR_NETWORK.html A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. 13/14 Gene Ontology CC GO:0031094 1.20015947173297e-05 2.10662432953734e-05 580 290.090909090909 254 1.09106001725212e-06 84 2.14835517548321 -1.44106323749223 -1 4.79737246450516 578 254 177 209 314 487 343 154 84 195 396 255 M17464 GO_BETA_CATENIN_DESTRUCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX.html A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. 17/18 Gene Ontology CC GO:0030877 0.000257863356172122 0.000320125234905989 300 264.818181818182 254 2.34448714050585e-05 76 1.73394347951684 1.65823567212958 1 2.87688133523 296 332 236 254 454 246 207 156 76 286 370 256 M17522 GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK.html The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. 957/1316 Gene Ontology CC GO:0042175 5.1847142640855e-07 3.31471465533457e-06 310 275 254 5.18471547374267e-08 40 1.78051334575339 -1.5579125024858 -1 4.65759819223372 221 309 551 476 40 155 195 307 254 243 274 257 M17169 GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. 54/63 Gene Ontology CC GO:0030660 4.50508453633683e-07 3.31471465533457e-06 295 234.090909090909 255 4.09553223533895e-08 14 1.52758204714361 -1.20380981251959 -1 3.99000504467767 294 227 298 139 14 255 163 291 307 343 244 258 M17384 GO_CELL_SUBSTRATE_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION.html A cell junction that forms a connection between a cell and the extracellular matrix. 532/642 Gene Ontology CC GO:0030055 6.50179259896786e-07 3.50797657915001e-06 255 276.909090909091 255 6.50179450126745e-08 61 1.91236657071033 2.21543494591047 1 4.98294461607683 255 262 534 386 61 308 354 213 247 189 237 259 M17208 GO_M_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_M_BAND.html The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. 28/40 Gene Ontology CC GO:0031430 4.88380994025743e-06 1.06891196867066e-05 490 268 256 4.43983707447934e-07 65 1.74553484556981 -1.62244326928657 -1 4.137731890939 489 77 228 183 242 378 390 256 65 325 315 260 M17493 GO_HEMOGLOBIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_COMPLEX.html An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. 3/15 Gene Ontology CC GO:0005833 0.000141837470374825 0.000186865238747785 260 305.545454545455 257 1.41846524228747e-05 9 2.11237614768737 -2.11237614768737 -1 3.75179496358973 159 257 548 278 492 142 9 571 469 257 179 261 M17119 GO_SECRETORY_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_VESICLE.html A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. 434/739 Gene Ontology CC GO:0099503 4.46672746345651e-11 7.86414744323707e-10 495 280.454545454545 258 4.06066133049747e-12 22 2.40250890972344 -2.11308466359481 -1 10.494120650758 494 163 22 117 75 472 530 494 258 44 416 262 M17505 GO_SECRETORY_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_MEMBRANE.html The lipid bilayer surrounding a secretory granule. 81/123 Gene Ontology CC GO:0030667 1.28922343736757e-05 2.23712501943113e-05 320 281.454545454545 259 1.17202817492385e-06 185 2.07356621183699 -1.95403359745554 -1 4.60283356788901 228 316 185 233 317 245 266 444 382 259 221 263 M17784 GO_CILIARY_BASAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASAL_BODY.html A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. 84/106 Gene Ontology CC GO:0036064 7.43295370614671e-06 1.45896827813217e-05 140 237.727272727273 260 6.75725347214251e-07 53 1.48795633392673 1.46934480912989 1 3.42413012038131 140 370 378 356 276 111 170 53 260 345 156 264 M17003 GO_MICROTUBULE_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. 1124/1355 Gene Ontology CC GO:0015630 1.91862294227596e-06 5.60160768574035e-06 220 293.272727272727 261 1.91862459877927e-07 160 1.59591573647979 1.70023201106869 1 3.99519874403149 220 308 511 477 178 160 235 258 270 348 261 265 M17618 GO_LATERAL_ELEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_ELEMENT.html A proteinaceous core found between sister chromatids during meiotic prophase. 8/115 Gene Ontology CC GO:0000800 4.43663671488499e-05 6.44421482837045e-05 95 269.909090909091 261 4.436725294228e-06 6 1.34113624665691 1.34113624665691 1 2.66537116997987 94 413 558 449 405 110 6 71 453 261 149 266 M17474 GO_EXTRACELLULAR_SPACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_SPACE.html That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. 1040/2139 Gene Ontology CC GO:0005615 2.09013657332519e-46 3.03592337275483e-44 335 265.181818181818 263 2.09013657332517e-47 2 2.8923217863022 3.09519626928099 1 60.586554241192 331 137 543 160 42 353 414 249 263 2 423 267 M17231 GO_PRONUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRONUCLEUS.html The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. 19/23 Gene Ontology CC GO:0045120 4.93372934145918e-06 1.06891196867066e-05 50 216.090909090909 264 4.48521855081481e-07 25 1.57225581843602 1.64974430810975 1 3.72281708406715 65 405 264 393 349 83 48 25 293 406 46 268 M17792 GO_NEURONAL_CELL_BODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_CELL_BODY_MEMBRANE.html The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. 23/44 Gene Ontology CC GO:0032809 1.12166248873779e-05 2.00518740294356e-05 265 248.818181818182 264 1.01969837048774e-06 89 2.28370233758065 2.0243196620472 1 5.12582640767287 264 89 130 314 307 282 245 201 417 134 354 269 M17409 GO_CHLORIDE_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_COMPLEX.html An ion channel complex through which chloride ions pass. 20/50 Gene Ontology CC GO:0034707 6.53442998718118e-06 1.32744888900429e-05 445 261.818181818182 265 5.94040854163282e-07 92 2.69293562066885 2.55170892223908 1 6.28424260074174 442 92 108 249 265 363 305 464 100 120 372 270 M17553 GO_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATION_FORK.html The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 74/81 Gene Ontology CC GO:0005657 0.000187925727954541 0.0002414088933645 25 235.545454545455 265 1.70856166034385e-05 23 1.48690604035444 1.55310736657179 1 2.54881856006371 23 318 265 390 439 75 34 172 356 310 209 271 M17796 GO_PHOTORECEPTOR_OUTER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT.html The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes. 72/111 Gene Ontology CC GO:0001750 7.53699545525774e-07 3.55843005277381e-06 100 255.636363636364 265 6.85181639760322e-08 25 2.21039402568086 2.08293904118386 1 5.75942959497754 541 25 97 28 70 404 497 265 303 97 485 272 M17217 GO_INTERMEDIATE_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT.html A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. 81/224 Gene Ontology CC GO:0005882 1.02731610671432e-10 1.70534473714577e-09 245 272.181818181818 267 9.3392373342026e-12 24 3.1772926726899 2.99133276097825 1 13.3774072440816 241 314 24 215 267 254 387 407 411 50 424 273 M17624 GO_PSEUDOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOPODIUM.html A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. 19/28 Gene Ontology CC GO:0031143 5.31868879890904e-07 3.31471465533457e-06 510 262.545454545455 267 4.83517280431648e-08 28 2.07780956775207 -2.4941728765813 -1 5.4422892197638 509 98 211 50 28 493 473 267 37 273 449 274 M17639 GO_CONDENSED_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. 215/358 Gene Ontology CC GO:0000793 3.16399282928726e-05 4.83757851004184e-05 25 221.181818181818 269 2.87639848551814e-06 8 1.55621765145789 1.54524397665566 1 3.19290607575967 8 391 374 357 412 23 25 97 345 269 132 275 M17783 GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX.html A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. 20/24 Gene Ontology CC GO:0000159 7.39804311910466e-05 0.000101374128589618 80 262.181818181818 270 6.72571991661904e-06 14 1.93802732400425 2.64041202727635 1 3.68661711764726 270 475 274 334 413 264 80 76 14 450 234 276 M16999 GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX.html A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. 24/29 Gene Ontology CC GO:0005669 5.37434060413366e-05 7.67197024816131e-05 225 299.090909090909 271 4.88588354311652e-06 173 1.70681263230599 1.97524922642108 1 3.34128216642117 191 402 271 453 389 218 223 173 330 415 225 277 M17073 GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX.html Any protein complex that is part of the plasma membrane and which functions as a receptor. 134/236 Gene Ontology CC GO:0098802 2.60911141727232e-07 2.58214189461065e-06 215 305.363636363636 272 2.37191975154771e-08 33 2.17468688746535 2.16850642550157 1 5.81160958282204 454 213 58 171 214 415 437 522 272 33 570 278 M17533 GO_MIDBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBODY.html A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. 172/198 Gene Ontology CC GO:0030496 1.37311487485042e-06 4.55874138450338e-06 275 275.818181818182 272 1.24828702897398e-07 138 1.61781304970167 1.90999056958695 1 4.1203118429842 314 271 279 272 138 313 347 294 265 270 271 279 M17065 GO_PLATELET_ALPHA_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE.html A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). 71/117 Gene Ontology CC GO:0031091 3.42764737946616e-06 8.29776303112432e-06 185 258.181818181818 273 3.11604792711477e-07 65 2.76249925977174 3.25049351191203 1 6.71918939710055 181 282 65 262 219 304 273 343 354 163 394 280 M17525 GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN.html The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. 23/28 Gene Ontology CC GO:0035327 7.20941723509227e-06 1.42958068723161e-05 295 237.454545454545 273 6.55403714592492e-07 77 2.13167091541313 -2.5113016405357 -1 4.93268044408008 291 326 192 311 273 291 148 202 203 298 77 281 M17714 GO_CYTOPLASMIC_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE.html Any microtubule in the cytoplasm of a cell. 66/84 Gene Ontology CC GO:0005881 2.74972277914029e-05 4.32950930807726e-05 270 288.363636363636 273 2.49977922528319e-06 212 1.86726001716584 1.80291881963938 1 3.88279882270036 267 319 212 287 354 273 241 383 231 268 337 282 M17528 GO_SCHMIDT_LANTERMAN_INCISURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHMIDT_LANTERMAN_INCISURE.html Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. 18/21 Gene Ontology CC GO:0043220 7.30599332010615e-06 1.44182158857833e-05 395 259.090909090909 274 6.641834166124e-07 5 1.98430273100703 -1.98737920058234 -1 4.58523272088516 395 102 216 110 274 422 548 405 5 304 69 283 M17223 GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the rough endoplasmic reticulum. 25/30 Gene Ontology CC GO:0030867 7.32078087143904e-06 1.44182158857833e-05 400 274.818181818182 275 6.65527748398682e-07 105 1.33078631044984 -1.02890699065611 -1 3.06130762414871 175 401 303 396 275 196 105 153 362 400 257 284 M17634 GO_IKAPPAB_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IKAPPAB_KINASE_COMPLEX.html A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 10/12 Gene Ontology CC GO:0008385 3.94400264113835e-05 5.84557534311576e-05 240 262 275 3.58552122561028e-06 95 1.23932857329855 -1.49744558070943 -1 2.48513287314847 400 119 286 275 374 387 161 239 237 309 95 285 M17081 GO_PLATELET_ALPHA_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_MEMBRANE.html The lipid bilayer surrounding the platelet alpha granule. 15/16 Gene Ontology CC GO:0031092 0.00091349024695078 0.00106573862144258 180 283.636363636364 276 8.30790699640353e-05 93 2.58650250621329 2.84848524390549 1 3.66126431922385 93 408 164 318 506 213 177 178 486 301 276 286 M17273 GO_BLOOD_MICROPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_MICROPARTICLE.html A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. 140/447 Gene Ontology CC GO:0072562 1.38718120097781e-09 1.91893399468597e-08 280 259.545454545455 276 1.26107381986589e-10 29 2.69532724274432 -2.53857138678725 -1 9.97698270507179 252 276 29 248 196 276 363 563 289 60 303 287 M17510 GO_POLE_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLE_PLASM.html Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. 6/18 Gene Ontology CC GO:0045495 7.11521878188282e-05 9.79607135609933e-05 365 270.909090909091 276 7.11544661067196e-06 46 3.00232368241881 3.24081038732547 1 5.75571767198199 363 124 549 206 406 344 275 86 46 276 305 288 M17240 GO_POTASSIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_COMPLEX.html An ion channel complex through which potassium ions pass. 57/123 Gene Ontology CC GO:0034705 3.35868032028243e-08 3.75267935785402e-07 40 272.545454545455 277 3.0533457923259e-09 14 3.27842405287639 -2.92064977122549 -1 10.105282203428 555 37 40 14 277 489 529 381 86 66 524 289 M17246 GO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME.html A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. 553/639 Gene Ontology CC GO:0005813 2.82242302981068e-06 7.22391092651984e-06 130 284.363636363636 278 2.82242661454938e-07 78 1.45399169916594 1.53035005653087 1 3.55881613353305 129 339 523 485 213 78 130 278 325 402 226 290 M17307 GO_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION.html A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. 1230/1673 Gene Ontology CC GO:0030054 1.04027132004593e-17 4.3171259781906e-16 280 245.363636363636 278 1.04027132004593e-18 9 2.27152601102777 2.48997163752157 1 16.7696602505042 278 133 528 141 99 289 342 334 182 9 364 291 M17323 GO_MICROVILLUS_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_MEMBRANE.html The portion of the plasma membrane surrounding a microvillus. 25/30 Gene Ontology CC GO:0031528 7.68312594712256e-06 1.50299534521152e-05 535 317.818181818182 278 6.98468434478618e-07 20 3.24986519829116 -2.77354746801048 -1 7.50812912358147 532 79 84 20 278 573 525 568 184 109 544 292 M17264 GO_ENDOPLASMIC_RETICULUM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_PART.html Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. 1099/1512 Gene Ontology CC GO:0044432 4.47603954934622e-07 3.31471465533457e-06 350 294.454545454545 281 4.47604045091832e-08 19 1.97650312388927 -1.6574526637841 -1 5.17489847730603 350 259 525 385 19 232 281 449 197 114 428 293 M17573 GO_PODOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PODOSOME.html An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. 30/34 Gene Ontology CC GO:0002102 2.68148200539822e-05 4.24507096767402e-05 150 228.818181818182 281 2.4377406266779e-06 45 2.17659069663366 2.09498143818232 1 4.54193870245088 281 72 148 148 352 293 306 312 45 184 376 294 M17581 GO_DESMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DESMOSOME.html A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. 30/36 Gene Ontology CC GO:0030057 5.92147208281046e-06 1.21568031099395e-05 560 348.363636363636 283 5.38317092815982e-07 142 2.33825533303715 2.32603488840141 1 5.49405981416552 556 236 142 267 260 551 559 283 495 145 338 295 M17731 GO_CILIARY_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PLASM.html All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. 74/119 Gene Ontology CC GO:0097014 8.12046960622852e-06 1.55197132934828e-05 285 263.727272727273 283 7.38227234548353e-07 194 1.8862574615117 1.98427724557636 1 4.32755303290699 292 283 194 349 284 235 283 299 211 266 205 296 M17187 GO_MCM_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MCM_COMPLEX.html A hexameric protein complex required for the initiation and regulation of DNA replication. 11/11 Gene Ontology CC GO:0042555 0.00874095737115369 0.00960018191425387 55 278.363636363636 284 0.000797807366371084 53 1.15229250549492 1.15229250549492 1 1.07798926075667 53 338 284 295 528 173 101 259 493 232 306 297 M17762 GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 145/190 Gene Ontology CC GO:0019897 4.65627223316775e-06 1.02559721245237e-05 415 314.363636363636 284 4.23298371648942e-07 148 1.85239034226801 -1.78967565638563 -1 4.40962599185356 412 275 182 269 239 394 472 404 284 148 379 298 M17133 GO_ANAPHASE_PROMOTING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX.html A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. 23/24 Gene Ontology CC GO:0005680 8.26675702359339e-06 1.57474945269107e-05 285 313 285 7.51526189732919e-07 184 1.29622039680351 1.42400260954705 1 2.95679050528026 184 432 326 426 285 261 257 216 393 380 283 299 M17718 GO_PIGMENT_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE.html A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. 115/141 Gene Ontology CC GO:0048770 5.71733577151573e-06 1.19059931299306e-05 310 296.727272727273 285 5.19759148156274e-07 211 1.8678643328049 -1.73484638219388 -1 4.38852015339971 310 280 253 211 256 285 226 454 347 323 319 300 M17367 GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 28/32 Gene Ontology CC GO:0031312 1.39183895933657e-05 2.37840716286632e-05 325 265.090909090909 287 1.26531614994584e-06 50 1.54187012724007 -1.93697811863286 -1 3.39208719157948 326 324 280 279 323 334 287 50 239 366 108 301 M17818 GO_GAP_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION.html A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons. 19/35 Gene Ontology CC GO:0005921 4.70977022625609e-05 6.82388154976257e-05 330 274.272727272727 287 4.28170096023457e-06 110 2.87912007341888 3.25970824051366 1 5.73556580001979 170 328 110 220 383 323 326 287 464 133 273 302 M16983 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. 10/18 Gene Ontology CC GO:0034362 8.58241236292158e-06 1.62953646498609e-05 575 289.181818181818 288 7.80222349447592e-07 3 3.6590348098598 -2.87205949379093 -1 8.39683351580231 572 335 149 128 288 502 471 63 3 214 456 303 M17045 GO_SECRETORY_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE.html A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. 326/584 Gene Ontology CC GO:0030141 1.88383710623711e-08 2.18901871744752e-07 585 344.727272727273 288 1.71257920215291e-09 38 2.49799134723755 -2.19338756193271 -1 7.97139632663043 581 266 38 165 126 560 573 580 288 105 510 304 M17295 GO_CILIARY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PART.html Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 291/415 Gene Ontology CC GO:0044441 1.06295526172722e-06 4.14481212794304e-06 315 303.545454545455 288 9.66323432096914e-08 112 1.67728606567545 1.70324016500924 1 4.30672136134414 311 268 287 418 112 212 412 438 312 288 281 305 M17457 GO_XY_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XY_BODY.html A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. 21/32 Gene Ontology CC GO:0001741 6.28128605451653e-05 8.74758155166052e-05 440 301.727272727273 290 5.71042309142676e-06 66 2.16421869136145 -3.22702832019907 -1 4.18854340403602 439 296 195 208 396 412 290 534 66 265 218 306 M17561 GO_ANCHORING_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORING_JUNCTION.html A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. 638/772 Gene Ontology CC GO:0070161 8.02331044601325e-07 3.55843005277381e-06 290 287 290 8.02331334282268e-08 74 2.04536376904517 2.35936278700237 1 5.3262939935155 290 261 554 284 95 337 398 320 251 74 293 307 M16986 GO_ENDOLYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME.html An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. 35/66 Gene Ontology CC GO:0036019 7.15439772215524e-06 1.4235291358124e-05 230 328.090909090909 291 6.50401908032287e-07 159 2.36740321804925 -2.78022344459054 -1 5.48490237625656 473 350 159 291 272 482 491 357 227 278 229 308 M17329 GO_ARP2_3_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_PROTEIN_COMPLEX.html A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. 10/11 Gene Ontology CC GO:0005885 9.15723257908759e-06 1.71072415705784e-05 295 298.454545454545 293 8.32479154107019e-07 118 1.00212553158076 -0.886860890444157 -1 2.25905838037615 382 118 316 293 293 349 274 235 259 396 368 309 M17511 GO_MEMBRANE_MICRODOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_MICRODOMAIN.html A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. 360/491 Gene Ontology CC GO:0098857 4.1970800205985e-10 6.25257305632751e-09 30 247.636363636364 293 3.8155272921811e-11 28 2.3711091540767 2.732682539651 1 9.3280367317174 354 173 28 167 139 398 455 293 301 29 387 310 M17841 GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT.html A distinct region of the endoplasmic reticulum 21/22 Gene Ontology CC GO:0098827 7.72464146239744e-06 1.50604586901104e-05 405 318.454545454545 294 7.02242598663363e-07 92 1.53362503930387 1.97334396127055 1 3.52032257651701 405 294 281 252 279 458 514 465 92 359 104 311 M17823 GO_DENSE_CORE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENSE_CORE_GRANULE.html Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. 10/17 Gene Ontology CC GO:0031045 1.61789328347456e-06 5.02671656523378e-06 340 276 297 1.47081315753116e-07 153 2.63994152174353 -2.80755031637882 -1 6.69603615892114 345 337 153 228 155 338 269 393 306 215 297 312 M17036 GO_NUCLEAR_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE.html The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. 21/30 Gene Ontology CC GO:0005640 1.42558465068594e-05 2.42892868635933e-05 300 266.363636363636 298 1.29599444405347e-06 62 1.43944517131197 -1.78082249063054 -1 3.15763913910081 298 404 288 421 324 262 159 66 340 306 62 313 M17135 GO_CELL_PROJECTION_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_CYTOPLASM.html All of the contents of a cell projection, excluding the plasma membrane surrounding the projection. 59/73 Gene Ontology CC GO:0032838 9.83214286856829e-06 1.80968378776423e-05 365 270 298 8.93835164565639e-07 100 1.38338140828567 -1.09219655430352 -1 3.11818992858238 250 287 315 368 298 144 154 365 365 324 100 314 M17327 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE.html A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. 55/77 Gene Ontology CC GO:0045334 1.24844877198802e-06 4.39605294863661e-06 510 295.727272727273 298 1.13495407314017e-07 42 1.89231311617929 -1.83833289973753 -1 4.84091998982502 507 42 157 135 127 480 546 560 298 99 302 315 M16990 GO_CONDENSED_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. 89/221 Gene Ontology CC GO:0000794 0.000193459468252926 0.000247576984702533 35 225.727272727273 299 1.75887711293615e-05 30 1.57519548246255 1.5935009121267 1 2.69433846505304 32 344 306 332 450 30 37 104 421 299 128 316 M17017 GO_PHOSPHATASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_COMPLEX.html A protein complex which is capable of phosphatase activity. 49/58 Gene Ontology CC GO:1903293 2.872679407076e-06 7.28832635594392e-06 300 330.818181818182 299 2.61153014374763e-07 189 1.28153305930618 1.64857851761923 1 3.12934964928843 299 464 386 514 206 286 189 281 200 496 318 317 M17075 GO_ACROSOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_MEMBRANE.html The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. 15/29 Gene Ontology CC GO:0002080 0.000100365142089297 0.000135295005925479 165 296.272727272727 300 9.12452009923995e-06 92 1.22757216858374 -1.29863149040077 -1 2.24565729256344 165 381 290 435 417 135 92 351 505 300 188 318 M17430 GO_SYNAPTONEMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX.html A proteinaceous scaffold found between homologous chromosomes during meiosis. 31/151 Gene Ontology CC GO:0000795 0.000182732035963622 0.000235927361988587 25 277.272727272727 300 1.66133832231525e-05 21 1.49100583477533 1.39457943534445 1 2.5631259285049 135 430 295 432 494 87 21 300 490 344 22 319 M17680 GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. 179/420 Gene Ontology CC GO:0009897 8.39757729883185e-11 1.4349977678298e-09 325 223.363636363636 301 7.63416118104763e-12 23 2.56882925397716 2.65958853107885 1 10.9003078503056 301 196 23 118 34 322 417 323 335 38 350 320 M17399 GO_NUCLEAR_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_HETEROCHROMATIN.html A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. 37/40 Gene Ontology CC GO:0005720 4.35431620448799e-05 6.3724375687847e-05 125 280.454545454545 302 3.95854762637337e-06 69 1.35746778658388 1.11807352843011 1 2.7015197843502 122 372 302 490 378 131 69 197 447 363 214 321 M17570 GO_EXOCYST http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYST.html A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. 20/21 Gene Ontology CC GO:0000145 5.65956057661148e-05 8.02339928903444e-05 245 303.181818181818 302 5.14518743237227e-06 64 1.53981356834475 -1.65705412697003 -1 2.99583214424202 243 377 289 361 438 298 302 64 465 356 142 322 M17585 GO_GOLGI_TRANSPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TRANSPORT_COMPLEX.html A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). 12/12 Gene Ontology CC GO:0017119 1.67177265097967e-05 2.79109169603215e-05 60 227.545454545455 303 1.51980486805396e-06 14 0.728305540122146 -0.728305540122146 -1 1.55575619801067 59 303 363 397 331 24 14 69 473 412 58 323 M17798 GO_BASAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PART_OF_CELL.html The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. 63/84 Gene Ontology CC GO:0045178 1.05542668770125e-05 1.89260156035317e-05 490 315.454545454545 303 9.59483410029961e-07 74 2.74248139734726 1.96683427524754 1 6.19714327410906 486 224 74 198 303 440 429 472 172 170 502 324 M17198 GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE.html The membrane surrounding the outer segment of a vertebrate photoreceptor. 11/19 Gene Ontology CC GO:0042622 4.60302360335452e-06 1.02465774465478e-05 555 321.727272727273 304 4.18457566746624e-07 28 2.13622941396315 -2.40174249232897 -1 5.09214141916454 551 304 197 179 238 550 575 28 363 233 321 325 M17610 GO_PHOTORECEPTOR_INNER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_INNER_SEGMENT.html The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. 35/55 Gene Ontology CC GO:0001917 2.80915294101719e-06 7.22391092651984e-06 555 334.363636363636 304 2.55377866181495e-07 64 1.7294879654118 1.62944667931362 1 4.24107100633498 554 64 198 273 203 567 511 304 428 167 409 326 M17407 GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE.html The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 53/65 Gene Ontology CC GO:0031228 1.31708812483465e-06 4.42328439612099e-06 445 323.181818181818 305 1.19735355758629e-07 45 2.03316248993835 2.47057696525141 1 5.20173581013724 485 45 167 305 135 445 444 547 214 213 555 327 M17103 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX.html A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. 99/124 Gene Ontology CC GO:0090575 1.12583977793175e-05 2.00648132201947e-05 240 353.090909090909 308 1.02349594491435e-06 212 1.22949006962937 1.38895248111261 1 2.74009771670133 238 455 443 558 308 257 222 212 412 495 284 328 M17209 GO_NPBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NPBAF_COMPLEX.html A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. 14/15 Gene Ontology CC GO:0071564 0.000503385728012814 0.000603024964897825 175 303.181818181818 308 4.57728132240258e-05 150 0.997889219591114 1.01358379274184 1 1.50566120789703 174 334 353 296 487 219 416 150 308 398 200 329 M17750 GO_MICROTUBULE_ORGANIZING_CENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER.html An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. 703/819 Gene Ontology CC GO:0005815 2.30122593709637e-06 6.39718789211959e-06 310 301.818181818182 308 2.30122832013821e-07 120 1.4708810075783 1.56501651784657 1 3.63803889717582 180 310 574 480 189 120 191 308 320 382 266 330 M17741 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated endocytic vesicle. 42/55 Gene Ontology CC GO:0030669 5.12944333878912e-07 3.31471465533457e-06 55 296.090909090909 309 4.66313139522968e-08 23 1.86376903654703 1.89624841089853 1 4.87734532900319 491 55 176 55 23 505 475 488 309 137 543 331 M17766 GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 34/45 Gene Ontology CC GO:0046658 2.90613458707093e-05 4.52671365975391e-05 375 265.636363636364 309 2.64197543359519e-06 63 2.86126695167161 2.69134618182484 1 5.94540794480977 375 63 77 302 357 309 311 380 147 82 519 332 M17315 GO_MYELIN_SHEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_SHEATH.html An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. 237/303 Gene Ontology CC GO:0043209 5.8670605698123e-06 1.2130826302708e-05 520 379.818181818182 311 5.33370565128731e-07 192 1.8716677675618 -1.73636326973607 -1 4.39021672838773 561 311 233 253 258 518 499 518 192 297 538 333 M17416 GO_RUFFLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_MEMBRANE.html The portion of the plasma membrane surrounding a ruffle. 127/146 Gene Ontology CC GO:0032587 4.36522140852514e-07 3.31471465533457e-06 380 255 311 3.96838388606265e-08 1 1.8730338718433 2.05942796729955 1 4.90179916524654 379 1 170 109 12 399 459 453 311 130 382 334 M17023 GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 18/21 Gene Ontology CC GO:0031362 0.00014111286428075 0.000186757572089101 390 316 312 1.28292651258865e-05 134 2.53278213443849 1.8342495689902 1 4.50712964763581 390 243 134 312 425 350 362 272 279 200 509 335 M17062 GO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CENTROMERIC_REGION.html The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 202/318 Gene Ontology CC GO:0000775 3.24488604083843e-05 4.93528478986159e-05 15 230.545454545455 313 2.94993991110454e-06 11 1.49994863948626 1.55750771839813 1 3.06966786738698 11 419 412 360 366 33 40 135 324 313 123 336 M17194 GO_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LUMEN.html The volume enclosed by the membrane or protein that forms a vesicle. 89/213 Gene Ontology CC GO:0031983 3.43976282653054e-07 3.17222571780039e-06 565 316.454545454545 315 3.12705760395218e-08 4 2.95083720829708 -2.79675910816557 -1 7.77370285842527 564 315 43 261 4 535 513 419 286 102 439 337 M17628 GO_PLASMA_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_REGION.html A membrane that is a (regional) part of the plasma membrane. 883/1317 Gene Ontology CC GO:0098590 2.52877835798979e-36 2.93844045198413e-34 385 288.272727272727 315 2.52877835798979e-37 3 2.49093948548582 2.66200198826095 1 40.1913264940859 385 140 560 63 91 315 379 528 162 3 545 338 M17064 GO_DNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_COMPLEX.html A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. 13/13 Gene Ontology CC GO:0042575 2.57860923776238e-06 6.84096788648375e-06 320 385.909090909091 316 2.34419296376601e-07 195 1.34648123198353 1.32119660649783 1 3.30791308032383 529 251 276 316 195 556 443 548 304 316 511 339 M17245 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX.html A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. 42/53 Gene Ontology CC GO:0016469 1.2776094968164e-05 2.22910245540639e-05 30 261.727272727273 316 1.16146992396242e-06 27 1.27331372405286 -1.31969341267031 -1 2.81123336051089 27 398 409 326 316 128 90 121 432 439 193 340 M17757 GO_NBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NBAF_COMPLEX.html A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 14/16 Gene Ontology CC GO:0071565 0.00113284878187696 0.00130851916952388 245 316.727272727273 316 0.000103039322000994 74 1.31235422439142 1.38307539386732 1 1.78067367509033 244 385 324 212 493 316 523 286 74 399 228 341 M17078 GO_COPI_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_VESICLE_COAT.html One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. 13/13 Gene Ontology CC GO:0030126 2.07980419961502e-06 5.95254305407058e-06 425 297.090909090909 318 1.89073287799351e-07 11 1.3175013616079 -1.15026699357476 -1 3.27415614856241 393 302 311 138 177 345 318 430 11 422 421 342 M17564 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. 89/112 Gene Ontology CC GO:0033116 4.53481764128007e-06 1.01335732676297e-05 550 359.818181818182 318 4.12256998985394e-07 79 2.51923792438437 -1.68059006024149 -1 6.01848346437819 566 220 124 197 237 549 557 550 79 318 561 343 M17219 GO_SNARE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_COMPLEX.html A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. 47/55 Gene Ontology CC GO:0031201 2.40179635198645e-05 3.88702975070787e-05 110 256.363636363636 321 2.18347506673927e-06 46 1.00314382563947 -1.00990782106587 -1 2.08916556539743 107 321 454 375 342 46 65 128 436 492 54 344 M17550 GO_INTRACILIARY_TRANSPORT_PARTICLE_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE_B.html The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. 22/24 Gene Ontology CC GO:0030992 6.29344077210688e-05 8.74758155166052e-05 265 287.727272727273 321 5.72147346630819e-06 33 1.19302815634964 1.32873294555895 1 2.29012223830254 261 353 330 319 397 247 384 105 415 321 33 345 M17704 GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX.html Any complex formed of proteins that act in nucleotide-excision repair. 15/16 Gene Ontology CC GO:0000109 0.000212717416205185 0.000268671345250462 230 303.818181818182 321 1.93398169618443e-05 103 0.970758954823296 1.04408115387317 1 1.62776701463778 230 382 354 321 516 233 103 108 438 445 212 346 M17799 GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX.html Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. 8/14 Gene Ontology CC GO:0005890 9.8426863499741e-06 1.80968378776423e-05 420 314.454545454545 321 9.84272994555944e-07 34 3.01537976078611 2.02541439806629 1 6.84624009793815 420 122 578 203 447 321 312 34 326 217 479 347 M17289 GO_NUCLEAR_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_REPLICATION_FORK.html The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 41/42 Gene Ontology CC GO:0043596 6.22003041722408e-05 8.68710978944036e-05 325 242.636363636364 322 5.65473298388073e-06 39 1.25214792515517 1.31237237617488 1 2.40750286300548 39 349 325 422 395 82 49 131 322 370 185 348 M17566 GO_GAMMA_TUBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_COMPLEX.html A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. 22/25 Gene Ontology CC GO:0000930 0.000235645255333491 0.000293798054396477 290 329.909090909091 322 2.14245908573691e-05 76 1.47379699556261 1.73926204521131 1 2.46542563487683 286 535 322 512 503 238 76 116 399 427 215 349 M17136 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. 19/26 Gene Ontology CC GO:0033177 3.89665573695765e-05 5.80489630718769e-05 65 266.818181818182 323 3.54247705137661e-06 61 1.32309922139582 -1.32309922139582 -1 2.65787914025585 61 406 337 323 373 183 109 142 359 438 204 350 M17826 GO_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of acetyltransferase activity. 100/110 Gene Ontology CC GO:1902493 0.000332975866787306 0.000408141305070517 190 359.818181818182 323 3.02751158412771e-05 152 1.20373986490198 1.37073756919368 1 1.92320295957748 190 506 480 571 463 266 152 182 294 531 323 351 M17149 GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX.html A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. 14/15 Gene Ontology CC GO:0005847 0.00203192759567894 0.00231480379037149 230 329.727272727273 325 0.000184891520114968 166 0.791218119373576 -0.791218119373576 -1 0.962500146638236 227 479 399 325 504 205 166 214 448 433 227 352 M17189 GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. 19/32 Gene Ontology CC GO:0032281 8.36068783539347e-05 0.000113827476473135 320 309.636363636364 325 7.60091416779717e-06 95 2.22887798946401 2.87932597388569 1 4.19215709748928 337 95 155 317 408 379 329 557 319 185 325 353 M17604 GO_AXOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXOLEMMA.html The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. 22/34 Gene Ontology CC GO:0030673 1.45116012479304e-05 2.46527494884432e-05 575 289.545454545455 325 1.31924517908936e-06 17 2.5968541120159 2.28375378161126 1 5.7222374448587 571 83 117 38 325 515 519 479 17 122 399 354 M17657 GO_REPLISOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLISOME.html A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. 28/29 Gene Ontology CC GO:0030894 0.000181896057633014 0.000235371067894836 425 263.272727272727 325 1.65373725949881e-05 23 1.02561230226334 1.05715527619714 1 1.75050512164537 42 325 357 425 436 88 23 152 422 418 208 355 M17154 GO_ROUGH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM.html The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. 79/110 Gene Ontology CC GO:0005791 4.7246971333691e-07 3.31471465533457e-06 530 334.909090909091 326 4.29518013458222e-08 16 2.17081106027052 -1.51532060824408 -1 5.68775966750618 530 317 171 276 16 441 483 384 167 326 573 356 M17301 GO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. 413/549 Gene Ontology CC GO:0000785 1.7792695776883e-05 2.94517271976325e-05 390 327.818181818182 327 1.61753087986571e-06 212 1.59750877562471 1.65171656351978 1 3.44457610429398 212 390 423 505 333 225 278 231 327 390 292 357 M17743 GO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM.html The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). 1541/2134 Gene Ontology CC GO:0005783 4.62622915140435e-07 3.31471465533457e-06 435 311.090909090909 327 4.62623011449446e-08 21 2.05814158406953 -1.69681347509405 -1 5.39037705545326 434 129 573 415 21 281 327 558 186 45 453 358 M17640 GO_ESC_E_Z_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESC_E_Z_COMPLEX.html A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. 19/20 Gene Ontology CC GO:0035098 0.000168299098236966 0.000218751176903081 305 334 328 1.53010885843682e-05 210 1.03280848636583 1.30676446834603 1 1.77890321844349 305 355 350 282 433 328 324 210 444 407 236 359 M17356 GO_PERICENTRIC_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIC_HETEROCHROMATIN.html Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. 17/18 Gene Ontology CC GO:0005721 2.52863230128119e-05 4.05838499183528e-05 150 313.272727272727 329 2.29878305936391e-06 150 1.18115121100046 1.36548484541562 1 2.45666857620616 150 477 329 486 346 253 220 157 471 392 165 360 M17530 GO_AXON_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_CYTOPLASM.html Any cytoplasm that is part of a axon. 34/40 Gene Ontology CC GO:1904115 6.14539876930758e-05 8.60355827703061e-05 205 285.909090909091 329 5.5868822175648e-06 47 1.29733860711934 -0.985803271626122 -1 2.49852717373519 202 399 312 362 394 167 47 416 341 329 176 361 M17708 GO_BAF_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BAF_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family. 20/23 Gene Ontology CC GO:0090544 0.000609331181203904 0.000716642543075846 330 312.090909090909 329 5.54090920317632e-05 118 1.20596108276162 1.20752838035594 1 1.78480503324514 196 329 342 256 483 278 451 330 118 385 265 362 M17282 GO_APICAL_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_DENDRITE.html A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. 21/30 Gene Ontology CC GO:0097440 7.85133109234111e-05 0.000107332314462357 430 314.727272727273 331 7.13782845783071e-06 28 2.30515242283989 2.77180539152786 1 4.36538451430124 427 241 166 111 407 455 547 331 28 307 442 363 M17242 GO_COPI_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a COPI-coated vesicle. 20/20 Gene Ontology CC GO:0030663 3.63747538128286e-07 3.21824270652728e-06 400 303.545454545455 332 3.30679634791128e-08 6 1.1280961359459 -0.929821829849066 -1 2.94256224832509 398 295 336 242 6 332 258 519 32 448 473 364 M17463 GO_BLOC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_COMPLEX.html Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. 20/21 Gene Ontology CC GO:0031082 1.72152881962659e-05 2.86592620115486e-05 160 280.636363636364 332 1.56503844632973e-06 48 0.86453602848375 -0.894823348432697 -1 1.84982079256054 160 439 391 509 332 137 54 89 515 413 48 365 M16980 GO_AGGRESOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGGRESOME.html An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. 38/47 Gene Ontology CC GO:0016235 5.80933343010391e-07 3.34276576503949e-06 355 295.454545454545 333 5.281213603746e-08 43 1.43920160743973 -1.38352782270823 -1 3.75419438821297 351 61 272 392 43 340 457 542 333 312 147 366 M16982 GO_RNA_CAP_BINDING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING_COMPLEX.html Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. 15/20 Gene Ontology CC GO:0034518 0.000887255924335502 0.00103930583072364 335 341 334 8.06921777429849e-05 72 1.11307468442554 1.36069852007851 1 1.55754782378783 333 547 356 371 496 283 72 175 334 480 304 367 M17666 GO_MHC_CLASS_II_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. 8/11 Gene Ontology CC GO:0042613 1.7626862334814e-05 2.92605914757913e-05 375 324 335 1.76270021541991e-06 89 2.40884964573575 -2.64296957316649 -1 5.21858116294733 372 306 566 202 335 339 320 378 408 89 249 368 M17011 GO_INFLAMMASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMASOME_COMPLEX.html A cytosolic protein complex that is capable of activating caspase-1. 6/12 Gene Ontology CC GO:0061702 0.00265047649867694 0.00299596662593639 245 341.363636363636 336 0.000265364307705139 124 1.70490477784314 1.11266677753296 1 2.03040784350313 242 364 512 481 510 259 124 233 474 220 336 369 M17281 GO_PROTEIN_DNA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX.html A macromolecular complex containing both protein and DNA molecules. 110/191 Gene Ontology CC GO:0032993 4.82527232808621e-05 6.95653405116151e-05 310 342.636363636364 336 4.38670742209493e-06 228 1.74565927705228 1.4215467423159 1 3.45403163579317 307 420 282 428 384 272 322 228 386 336 404 370 M17069 GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX.html A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. 16/16 Gene Ontology CC GO:0005671 0.0115804195191028 0.0126233090817988 340 385.454545454545 337 0.00105834817081362 99 0.535726634178644 0.50270146195588 1 0.448063242157269 312 487 429 337 533 277 99 337 554 543 332 371 M17137 GO_MALE_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GERM_CELL_NUCLEUS.html The nucleus of a male germ cell, a reproductive cell in males. 18/33 Gene Ontology CC GO:0001673 0.000585480129920905 0.00069279828000824 310 353.181818181818 337 5.32396363875169e-05 201 1.96342511350079 1.89474048780443 1 2.9460775619159 306 380 201 333 481 294 316 428 420 337 389 372 M17538 GO_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN.html A compact and highly condensed form of chromatin. 76/86 Gene Ontology CC GO:0000792 2.25518318190514e-05 3.68050963114294e-05 220 350.272727272727 338 2.05018754522026e-06 216 1.29985007324645 1.21166146528418 1 2.73433939808832 216 395 401 510 338 326 300 288 449 377 253 373 M17839 GO_PRIMARY_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_LYSOSOME.html A lysosome before it has fused with a vesicle or vacuole. 18/68 Gene Ontology CC GO:0005766 0.00286953857395453 0.00323728526498559 340 342.181818181818 338 0.000261208024053623 248 1.74840346404221 -2.1134247050642 -1 2.0549468791759 356 331 248 258 509 305 262 426 392 338 339 374 M17140 GO_GEMINI_OF_COILED_BODIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_GEMINI_OF_COILED_BODIES.html Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). 10/11 Gene Ontology CC GO:0097504 0.00104201247838924 0.00121081849988829 260 337.181818181818 339 9.47733042559345e-05 106 0.958263647672789 1.05227000554524 1 1.30446604194527 256 446 339 433 536 202 106 184 513 395 299 375 M17623 GO_ACROSOMAL_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_VESICLE.html A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. 80/154 Gene Ontology CC GO:0001669 5.26698529568838e-06 1.1168315535748e-05 345 349.181818181818 342 4.78817991394277e-07 230 1.95060403735376 -1.73116911639951 -1 4.61087294287199 430 345 230 423 250 407 490 275 337 342 312 376 M17253 GO_MOTILE_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM.html A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles. 90/165 Gene Ontology CC GO:0031514 3.99490206476164e-06 9.24716374353194e-06 375 332.545454545455 343 3.63173574452839e-07 138 1.4429625173707 1.43628385323921 1 3.45696780161548 373 343 313 501 227 384 395 138 338 374 272 377 M17442 GO_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COMPLEX.html A protein complex which is capable of ATPase activity. 24/33 Gene Ontology CC GO:1904949 1.01474334099104e-05 1.83941640207471e-05 470 303.545454545455 344 9.22498201358371e-07 32 2.45323020309982 -2.23735807191431 -1 5.55373234809471 468 351 158 290 410 451 344 32 424 168 243 378 M17698 GO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS.html A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. 1482/1929 Gene Ontology CC GO:0005794 5.29395680604821e-07 3.31471465533457e-06 440 307.727272727273 344 5.29395806721766e-08 45 1.92569021709983 -1.64229086046423 -1 5.04078162989929 436 130 569 384 45 260 365 515 226 111 344 379 M17729 GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. 23/29 Gene Ontology CC GO:0031233 0.000206252364735799 0.00026221580724617 500 328.727272727273 345 1.87519730595454e-05 118 2.68726412388276 -3.54027867877533 -1 4.59381851183247 500 238 118 346 443 519 494 155 275 183 345 380 M17806 GO_GOLGI_CISTERNA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA_MEMBRANE.html The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. 72/86 Gene Ontology CC GO:0032580 1.12532722693946e-06 4.19513138275404e-06 560 328 345 1.02302527505334e-07 30 1.61970165139554 -1.16544288667525 -1 4.15333506269985 560 30 227 345 117 372 400 496 249 271 541 381 M17230 GO_CILIARY_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TIP.html Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. 55/63 Gene Ontology CC GO:0097542 1.01943559633056e-05 1.83941640207471e-05 235 329.363636363636 347 9.26763927472731e-07 205 1.23971290274143 1.18989781476398 1 2.78577497934034 234 371 369 484 302 237 422 205 397 347 255 382 M17768 GO_MAST_CELL_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_GRANULE.html Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. 22/48 Gene Ontology CC GO:0042629 1.63691076434088e-05 2.7407641328013e-05 490 361.818181818182 347 1.48811176718907e-06 136 1.97212908873613 -2.21618006327883 -1 4.29184780452442 488 293 183 387 329 561 555 136 379 322 347 383 M16989 GO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME.html A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. 863/1183 Gene Ontology CC GO:0005694 4.13858620546764e-05 6.08738882373848e-05 70 298.454545454545 351 4.13866328301894e-06 69 1.48851391054142 1.52411122523199 1 2.98061497568612 69 415 510 465 382 93 144 167 351 485 202 384 M17107 GO_SMN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_COMPLEX.html A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. 12/13 Gene Ontology CC GO:0032797 0.000164643851399719 0.000214479994760621 225 312.454545454545 351 1.49687431205653e-05 129 0.836117184735819 0.931239195857177 1 1.43558640599745 225 363 351 430 432 175 129 159 501 409 263 385 M17490 GO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION.html A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 1734/2090 Gene Ontology CC GO:0005739 1.50558155873949e-06 4.88626405561422e-06 550 400.727272727273 351 1.50558257878959e-07 156 1.51525943813758 -1.3982476081359 -1 3.83447330016775 273 568 546 550 156 343 351 336 348 564 373 386 M17165 GO_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_NUCLEUS.html The nucleus of a germ cell, a reproductive cell in multicellular organisms. 20/37 Gene Ontology CC GO:0043073 0.000894056070917894 0.00104516413924205 280 339.545454545455 353 8.13108738574964e-05 215 1.87566772935466 1.78536226735362 1 2.65118331689802 280 379 215 297 486 270 254 410 429 353 362 387 M17389 GO_ENDOCYTIC_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_LUMEN.html The volume enclosed by the membrane of an endocytic vesicle. 21/38 Gene Ontology CC GO:0071682 5.9214046453204e-05 8.33011161968802e-05 235 331.636363636364 353 5.38324002613534e-06 150 2.85780084518897 -2.92441938722476 -1 5.57354776762604 338 378 150 231 392 405 353 536 370 264 231 388 M17470 GO_AXONEME_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_PART.html Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 18/32 Gene Ontology CC GO:0044447 7.96242787186071e-06 1.53693375201032e-05 535 384.272727272727 354 7.23859699118695e-07 186 2.16325742704635 1.75110130576164 1 4.97362531958882 535 354 186 353 281 508 477 511 257 230 535 389 M17483 GO_SPERM_PRINCIPAL_PIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PRINCIPAL_PIECE.html The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. 20/29 Gene Ontology CC GO:0097228 1.07602379316656e-06 4.14989511278817e-06 190 308.818181818182 354 9.78203926774563e-08 9 1.23835824929407 1.38765501517663 1 3.16840756578268 186 356 293 450 330 354 415 9 483 384 137 390 M17080 GO_CYTOPLASMIC_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SIDE_OF_MEMBRANE.html The side of a membrane that faces the cytoplasm. 184/232 Gene Ontology CC GO:0098562 2.05034927631364e-06 5.89729173038726e-06 175 352.818181818182 355 1.86395562472217e-07 172 1.84374847055782 -1.79700382645069 -1 4.60229219423861 481 340 213 310 175 471 508 412 355 172 444 391 M17440 GO_SMOOTH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_ENDOPLASMIC_RETICULUM.html The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. 43/64 Gene Ontology CC GO:0005790 2.82571002115728e-05 4.41327290938812e-05 455 338.818181818182 356 2.56886028692275e-06 159 1.49886282891528 -1.27278592069996 -1 3.10246861491468 453 348 310 159 356 403 369 226 380 388 335 392 M17555 GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX.html A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. 18/22 Gene Ontology CC GO:0005732 0.000350757630072961 0.000428130636706703 360 305.272727272727 357 3.18921423365386e-05 20 0.872129834404538 0.938025487408848 1 1.37311762149315 56 357 358 504 489 139 20 236 492 430 277 393 M17717 GO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOST.html Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. 17/20 Gene Ontology CC GO:0018995 3.15919581571371e-05 4.83757851004184e-05 355 349.181818181818 357 2.87203743874327e-06 248 1.6364270820861 -1.43619954539671 -1 3.35963377886365 413 248 256 354 364 419 372 359 346 357 353 394 M17171 GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the cytoplasm. 17/18 Gene Ontology CC GO:0000177 0.000158543465080962 0.0002069971982293 305 355.727272727273 358 1.4414081063832e-05 158 1.24726482384719 1.6791336165915 1 2.17139916831972 304 478 341 506 431 301 158 200 445 391 358 395 M17532 GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 124/154 Gene Ontology CC GO:0044798 1.01903127352467e-05 1.83941640207471e-05 320 399.818181818182 358 9.26396357879739e-07 279 1.25510945326212 1.41802880277762 1 2.82089355198414 319 500 468 564 301 318 279 358 434 509 348 396 M17679 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE.html A cellular membrane associated with the pre-autophagosomal structure. 18/18 Gene Ontology CC GO:0034045 5.90173778031863e-06 1.21568031099395e-05 355 362 358 5.36523055675232e-07 259 0.775653594559964 -0.883211513342816 -1 1.79448442615012 355 330 407 401 259 358 313 362 457 465 275 397 M17038 GO_CATION_TRANSPORTING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_COMPLEX.html Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 14/21 Gene Ontology CC GO:0090533 1.52725276642785e-06 4.88626405561422e-06 460 322.636363636364 359 1.38841256968783e-07 12 2.26639119135317 -2.68866645753488 -1 5.75605301915396 457 359 162 330 453 547 447 12 364 176 242 398 M17683 GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. 49/80 Gene Ontology CC GO:0031463 1.1590142314522e-05 2.04056748022342e-05 315 406.272727272727 360 1.05365485224537e-06 270 1.80130464806391 2.12480542972522 1 4.02762439245985 521 516 301 500 312 557 542 277 313 360 270 399 M17134 GO_NUCLEAR_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INCLUSION_BODY.html An intranuclear focus at which aggregated proteins have been sequestered. 14/14 Gene Ontology CC GO:0042405 0.000133705565157483 0.000177764149557203 225 343.909090909091 361 1.21557901671839e-05 92 1.06974182998317 1.19416860694044 1 1.89044642657686 222 557 361 372 547 292 198 92 454 432 256 400 M17593 GO_CIS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. 49/52 Gene Ontology CC GO:0005801 4.07123099030536e-06 9.34934863781586e-06 420 353.181818181818 361 3.70112593125476e-07 229 1.12929316435014 -0.864330231633595 -1 2.69378498152431 417 347 392 483 229 274 232 403 328 419 361 401 M17626 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT.html A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. 141/169 Gene Ontology CC GO:0005793 7.98505998807577e-07 3.55843005277381e-06 395 300.909090909091 361 7.25914807846622e-08 77 2.06574245832545 -1.57711021411843 -1 5.37977955439605 394 277 180 152 77 380 413 517 133 361 426 402 M17689 GO_DENDRITE_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_CYTOPLASM.html All of the contents of a dendrite, excluding the surrounding plasma membrane. 19/26 Gene Ontology CC GO:0032839 3.05141518139567e-05 4.69105507430133e-05 405 339.545454545455 361 2.77405227777879e-06 140 1.83097101465983 -1.45841356393578 -1 3.77580410786531 404 244 234 140 361 452 565 376 384 274 301 403 M17759 GO_MEDIATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEDIATOR_COMPLEX.html A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. 36/36 Gene Ontology CC GO:0016592 1.174302321611e-06 4.19513138275404e-06 365 345.181818181818 361 1.06754813493024e-07 123 1.13255398555248 -1.18219905449918 -1 2.89155021063253 435 322 404 543 123 361 361 245 329 423 251 404 M17767 GO_AXONEMAL_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX.html A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 13/21 Gene Ontology CC GO:0005858 9.28949186831696e-06 1.72434337875149e-05 500 381.818181818182 361 8.44502826672174e-07 161 2.53476665635699 2.11224190294532 1 5.77396759112759 498 361 161 350 295 467 484 561 220 229 574 405 M17290 GO_INVADOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_INVADOPODIUM.html A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. 14/17 Gene Ontology CC GO:0071437 0.000521510176998055 0.000619626611116299 330 361.181818181818 363 4.74212583700144e-05 187 1.55285431630203 2.08459380123167 1 2.3575162881113 327 444 257 363 477 400 423 187 437 330 328 406 M17554 GO_IMMUNOGLOBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_COMPLEX.html A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. 3/117 Gene Ontology CC GO:0019814 2.7842639373943e-05 4.37204688547591e-05 465 322.545454545455 363 2.78429882257498e-06 82 4.15742999654114 2.91825454216393 1 8.68792775649105 461 126 553 124 363 409 323 445 82 187 475 407 M17112 GO_BLOC_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_1_COMPLEX.html A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. 15/16 Gene Ontology CC GO:0031083 3.21337345920864e-05 4.90018367401632e-05 275 341 365 2.92129126862001e-06 144 0.814451215999493 -0.850563842714524 -1 1.64883906326874 274 483 372 494 365 275 179 144 540 443 182 408 M17220 GO_DNA_REPLICATION_FACTOR_A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_FACTOR_A_COMPLEX.html A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. 14/14 Gene Ontology CC GO:0005662 3.29878480749241e-05 4.99113013841951e-05 370 293.909090909091 365 2.99894024734702e-06 26 0.832316875366009 0.812347293371146 1 1.68272561659438 133 443 365 370 368 109 26 225 484 477 233 409 M17050 GO_SAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_COMPLEX.html A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. 8/9 Gene Ontology CC GO:0000124 0.0039140087304809 0.00436475829637122 260 366.818181818182 367 0.000392091962682284 97 0.712850468115504 0.728579206025243 1 0.768434290008838 260 414 514 367 517 296 97 303 491 420 356 410 M17514 GO_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIDE_OF_MEMBRANE.html A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. 395/702 Gene Ontology CC GO:0098552 6.81447420740252e-07 3.55558405870747e-06 55 333.272727272727 368 6.19497847107166e-08 42 2.12135998401839 -1.9867817955711 -1 5.5261074337213 567 167 52 216 55 539 544 565 368 42 551 411 M17527 GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX.html A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. 18/26 Gene Ontology CC GO:0034663 0.14490016393597 0.151415459076975 370 358.818181818182 368 0.0141298639037694 213 2.13443929077252 2.35083044857912 1 0.800958419367686 257 544 241 213 573 370 368 392 217 429 343 412 M17551 GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX.html RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 13/15 Gene Ontology CC GO:0005736 0.000505776984615407 0.000604264303979818 180 334.363636363636 368 4.59902999535947e-05 68 0.728865504986853 0.787373706034565 1 1.08812798138347 176 489 368 459 480 211 68 151 528 469 279 413 M17054 GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of H4 histone acetyltransferase activity. 23/27 Gene Ontology CC GO:1902562 3.90656532893354e-05 5.80489630718769e-05 425 287.090909090909 369 3.55148609089857e-06 57 2.59578721850466 3.83641123993702 1 5.25482603315744 424 434 239 369 466 385 206 57 61 437 80 414 M17110 GO_SCF_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). 35/37 Gene Ontology CC GO:0019005 3.60863673202432e-05 5.4036544879024e-05 415 387.818181818182 371 3.28063265951845e-06 292 1.83272641823494 -1.61619890046836 -1 3.72524539001958 414 466 292 482 371 433 520 322 302 334 330 415 M17611 GO_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUCHROMATIN.html A dispersed and relatively uncompacted form of chromatin. 41/56 Gene Ontology CC GO:0000791 0.000220643116864927 0.000278077333836275 390 367.636363636364 371 2.00604771621717e-05 244 1.89757105859858 1.40223241629333 1 3.20821908146382 357 428 244 452 448 342 319 386 390 371 307 416 M17506 GO_DNA_PACKAGING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING_COMPLEX.html A protein complex that plays a role in the process of DNA packaging. 41/109 Gene Ontology CC GO:0044815 5.88999938632317e-05 8.30604282391689e-05 450 331.818181818182 372 5.35468825778614e-06 80 2.43265525735933 -3.0082099157618 -1 4.73962377996879 450 231 104 416 391 297 282 499 372 80 528 417 M17575 GO_AUTOPHAGOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_MEMBRANE.html The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. 27/34 Gene Ontology CC GO:0000421 1.54801450708665e-05 2.622147022208e-05 355 341.363636363636 373 1.40729581789911e-06 18 1.13338041250631 -1.17061735914896 -1 2.45917598844967 352 525 373 515 326 197 141 506 413 389 18 418 M17638 GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. 26/29 Gene Ontology CC GO:0080008 0.00051209994650381 0.000609692764177692 210 313.454545454545 374 4.65653807502786e-05 57 0.739181385829065 -0.71000983206832 -1 1.10273916955333 207 374 433 441 476 95 57 264 489 501 111 419 M17710 GO_MICROTUBULE_ORGANIZING_CENTER_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_PART.html Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. 163/194 Gene Ontology CC GO:0044450 9.2427868044681e-06 1.72117279916537e-05 285 353.636363636364 374 8.40256876009925e-07 182 1.3984574831027 1.38215584427536 1 3.16729910280218 285 450 458 374 294 182 212 414 403 455 363 420 M17701 GO_PERICENTRIOLAR_MATERIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIOLAR_MATERIAL.html A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. 23/25 Gene Ontology CC GO:0000242 5.79349971032184e-06 1.20215118989178e-05 535 407 375 5.26683178821103e-07 257 1.44259690936357 -1.4612430509883 -1 3.37689945171648 531 375 328 322 257 578 581 317 402 351 435 421 M17001 GO_CENTRIOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE.html A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. 111/137 Gene Ontology CC GO:0005814 5.83587077426042e-05 8.24973459816375e-05 165 302.727272727273 376 5.30547780574314e-06 81 1.25128766752343 1.26513553179726 1 2.41934243818002 161 421 469 376 390 81 104 223 462 452 191 422 M17369 GO_PLATELET_DENSE_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet dense granule. 9/15 Gene Ontology CC GO:0031089 3.83170919623086e-05 5.72293841390779e-05 535 391.909090909091 376 3.83177526681337e-06 169 2.92078981758925 -3.62615254854185 -1 5.9266889256398 563 307 531 169 376 576 539 316 204 197 533 423 M17804 GO_METHYLOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLOSOME.html A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. 12/17 Gene Ontology CC GO:0034709 0.00308397087961819 0.00346573903492876 540 348.363636363636 377 0.000280754773506727 59 0.567106636686149 0.567106636686149 1 0.630114576873218 86 388 377 402 538 207 59 298 538 580 359 424 M17713 GO_SWI_SNF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_COMPLEX.html A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. 13/15 Gene Ontology CC GO:0016514 0.00136745699312194 0.00157325250099772 355 397.909090909091 378 0.000124391609600692 298 1.03617452830283 0.971081042189097 1 1.3571753853336 378 411 347 298 497 359 560 433 352 387 355 425 M17838 GO_CHYLOMICRON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHYLOMICRON.html A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. 5/15 Gene Ontology CC GO:0042627 1.04324598634296e-05 1.8765508299234e-05 390 320.363636363636 378 1.04325088400516e-06 90 2.67502960802202 3.50935541413278 1 6.04845822332744 421 389 580 388 311 477 378 99 141 250 90 426 M17124 GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription. 25/28 Gene Ontology CC GO:0090568 4.40514736271204e-05 6.41451282640525e-05 370 402.272727272727 379 4.00475961018156e-06 366 1.19675155177233 1.09952656781615 1 2.37506348302589 369 431 375 366 379 392 442 487 439 368 377 427 M17404 GO_PROTEASOME_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_CORE_COMPLEX.html A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. 18/22 Gene Ontology CC GO:0005839 0.0119049581055218 0.01295277277024 385 343.545454545455 383 0.00108817020488757 120 1.34384239486984 -1.34384239486984 -1 1.17995387748568 120 410 385 400 551 279 230 271 383 428 322 428 M17556 GO_SMN_SM_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_SM_PROTEIN_COMPLEX.html A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. 16/21 Gene Ontology CC GO:0034719 0.00163648209533042 0.00187164586099798 105 339.727272727273 383 0.000148881879158617 91 0.753890732593709 0.763596502410993 1 0.948628145916161 104 409 383 493 501 168 91 276 522 456 334 429 M17649 GO_CHROMATOID_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATOID_BODY.html A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). 8/15 Gene Ontology CC GO:0033391 0.0216349485982453 0.0232345751119787 565 383.363636363636 383 0.00218485127031105 56 2.62651066126981 2.00295848022077 1 2.02515764008849 433 563 563 235 553 383 216 302 56 364 549 430 M17202 GO_ORGANELLE_MEMBRANE_CONTACT_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_CONTACT_SITE.html A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. 12/13 Gene Ontology CC GO:0044232 0.00044335065148698 0.000535523344103816 560 376.818181818182 387 4.03127292787302e-05 183 1.29016400356844 -1.48394134373245 -1 1.99098095743837 559 387 317 324 472 529 330 183 404 410 230 431 M17269 GO_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME.html A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. 501/765 Gene Ontology CC GO:0000228 6.67889181081453e-05 9.26118410998388e-05 105 320.727272727273 387 6.67909255348713e-06 101 1.43572646679425 1.47056800472609 1 2.74739731271911 101 416 526 471 404 121 162 196 387 490 254 432 M17489 GO_MITOCHONDRIAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PART.html Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 988/1145 Gene Ontology CC GO:0044429 4.48556851286455e-06 1.00622212585881e-05 575 422.363636363636 388 4.48557756703647e-07 245 1.37388717261481 -1.25950787576994 -1 3.26519596286715 254 571 545 574 245 367 388 346 388 563 405 433 M17021 GO_SPERM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PART.html Any constituent part of a sperm, a mature male germ cell that develops from a spermatid. 128/232 Gene Ontology CC GO:0097223 2.77522086890866e-06 7.20585696891978e-06 470 383.363636363636 389 2.52293124523286e-07 201 1.81252136004406 1.76301253627677 1 4.44764850309293 469 279 231 389 201 488 504 497 297 341 521 434 M16988 GO_CYTOCHROME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX.html A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 18/29 Gene Ontology CC GO:0070069 0.0249134313357454 0.0266569127183574 395 369.363636363636 391 0.00229091942502533 10 2.00251307558157 -0.601558457331708 -1 1.47650362038145 377 358 255 237 535 391 391 516 10 463 530 435 M17147 GO_SEX_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_CHROMOSOME.html A chromosome involved in sex determination. 35/46 Gene Ontology CC GO:0000803 3.33689620071677e-05 5.02263391869545e-05 580 395 391 3.03358801351404e-06 160 1.84401969481434 1.18784369228236 1 3.77666572392959 467 465 246 391 369 534 577 251 160 308 577 436 M17308 GO_NUCLEAR_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. 275/368 Gene Ontology CC GO:0000790 4.32130784029522e-05 6.34010064447354e-05 395 391.909090909091 391 3.92853883917325e-06 328 1.57057732891744 1.62463811457951 1 3.13388728373995 391 365 400 457 377 371 428 328 343 405 446 437 M17259 GO_PML_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PML_BODY.html A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. 109/135 Gene Ontology CC GO:0016605 0.000133362874774859 0.000177715206982094 455 365.090909090909 393 1.21246327136622e-05 208 1.80778779568633 1.79051359581383 1 3.22375521552919 343 393 318 454 424 312 208 476 219 414 455 438 M17565 GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. 105/135 Gene Ontology CC GO:0031234 5.35402861377527e-06 1.12706182050849e-05 455 361.909090909091 394 4.86731058513457e-07 221 1.719904403786 -1.70575706126759 -1 4.0573008219342 452 281 243 420 252 423 510 348 394 221 437 439 M17354 GO_NUCLEAR_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EUCHROMATIN.html The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. 33/47 Gene Ontology CC GO:0005719 0.000309475719896136 0.000380943629787405 455 398.636363636364 395 2.81381147875552e-05 220 2.02490068276569 -2.54151129359542 -1 3.29298090304966 455 429 220 395 461 386 341 576 367 340 415 440 M17703 GO_TELOMERE_CAP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAP_COMPLEX.html A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. 14/14 Gene Ontology CC GO:0000782 0.00104974439955972 0.00121736825577684 310 382.090909090909 395 9.54768751665642e-05 203 0.82345131855905 0.842243506081858 1 1.11411998749052 308 485 395 508 490 284 203 242 497 478 313 441 M17031 GO_HOLO_TFIIH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOLO_TFIIH_COMPLEX.html A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. 12/12 Gene Ontology CC GO:0005675 0.00182341042588384 0.00208133881618568 460 396.727272727273 397 0.000165902133289976 239 0.817614787689563 0.896404715090889 1 1.01419395758061 397 488 379 456 502 362 239 289 482 460 310 442 M17101 GO_PERINUCLEAR_REGION_OF_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_REGION_OF_CYTOPLASM.html Cytoplasm situated near, or occurring around, the nucleus. 774/983 Gene Ontology CC GO:0048471 7.77536205742123e-07 3.55843005277381e-06 540 332.636363636364 397 7.77536477795405e-08 90 1.88976104172378 -1.72163036127378 -1 4.91790172496161 536 145 515 196 90 442 522 409 256 151 397 443 M17130 GO_CHROMOSOMAL_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOMAL_REGION.html Any subdivision of a chromosome along its length. 337/530 Gene Ontology CC GO:0098687 9.32386561187165e-05 0.000126274263881059 445 281.363636363636 398 8.47660072000084e-06 22 1.40301190444908 1.43613072658966 1 2.59284257934013 22 418 482 444 415 69 73 149 398 441 184 444 M17443 GO_NUCLEAR_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. 59/73 Gene Ontology CC GO:0005637 3.85104494896886e-06 9.05853083138019e-06 225 376.363636363636 400 3.50095608194836e-07 225 1.34108251766728 -1.26516956037928 -1 3.21571084263894 493 225 344 502 225 411 432 400 371 303 434 445 M17738 GO_MITOCHONDRIAL_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ENVELOPE.html The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. 713/833 Gene Ontology CC GO:0005740 5.00779463505028e-06 1.073626820282e-05 575 423.454545454545 400 5.00780592018927e-07 251 1.35345643156389 -1.24172288110981 -1 3.19765812667077 251 575 571 498 254 377 382 345 400 575 430 446 M17755 GO_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REGION.html A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane. 1088/1581 Gene Ontology CC GO:0098589 7.86996142864385e-33 7.62074598340346e-31 575 310.454545454545 401 7.86996142864383e-34 4 2.39454504767401 2.58317798332184 1 34.6967440192769 426 136 575 64 76 401 435 527 199 4 572 447 M17448 GO_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases. 22/25 Gene Ontology CC GO:0000178 0.000390473627471884 0.00047263578658576 270 374.454545454545 402 3.55039044623474e-05 183 1.24726482384719 1.6791336165915 1 1.95597858563655 266 536 402 464 470 299 183 232 458 426 383 448 M17832 GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the nucleus. 43/47 Gene Ontology CC GO:0000152 9.89577845341497e-06 1.81370576701391e-05 370 405 402 8.99620269609951e-07 299 1.1415127771234 1.3297723026614 1 2.56514796943651 349 427 389 489 299 402 482 369 456 424 369 449 M16997 GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the nucleus. 15/15 Gene Ontology CC GO:0000176 0.00163367436900394 0.00187164586099798 305 384.545454545455 403 0.000148626251308377 114 1.0426849711833 1.27484418111772 1 1.32808410466615 302 490 390 461 500 311 114 321 511 403 427 450 M17131 GO_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INCLUSION_BODY.html A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. 78/96 Gene Ontology CC GO:0016234 3.19516272446953e-06 7.80316236230008e-06 440 384.090909090909 403 2.9046976045118e-07 215 1.43240708793895 1.50124215571967 1 3.48224994116379 440 457 332 403 215 376 294 338 407 416 547 451 M17479 GO_CHD_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHD_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. 20/23 Gene Ontology CC GO:0090545 0.000188224145773009 0.0002414088933645 440 392.636363636364 403 1.71127501352819e-05 281 1.18682359785558 1.07372250818609 1 2.02596169288993 415 376 348 281 440 438 441 523 299 355 403 452 M17663 GO_INTERCELLULAR_BRIDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCELLULAR_BRIDGE.html A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. 49/52 Gene Ontology CC GO:0045171 4.37138815497133e-07 3.31471465533457e-06 405 401.909090909091 404 3.97399002142185e-08 13 1.33232236453379 -1.22380274867253 -1 3.47463179185854 505 396 367 488 13 516 404 363 461 401 507 453 M17099 GO_RNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_COMPLEX.html Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. 124/133 Gene Ontology CC GO:0030880 7.0306995450776e-06 1.40856428816899e-05 330 417 406 6.39156546699503e-07 270 1.02713424994299 1.17955120581458 1 2.35824023927059 330 501 491 569 270 388 406 279 435 526 392 454 M17847 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. 32/39 Gene Ontology CC GO:0000307 0.000608741199715166 0.000716642543075846 380 388.909090909091 406 5.53554276378206e-05 160 1.46463012167451 1.79551661436642 1 2.17662576377026 383 527 376 406 543 416 200 160 416 471 380 455 M17338 GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX.html A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. 15/19 Gene Ontology CC GO:0033276 2.42405508893221e-05 3.91215557408226e-05 485 407.181818181818 408 2.20371072602812e-06 225 0.774190814206785 0.771079757512862 1 1.60172976483006 408 482 398 439 343 365 225 474 499 481 365 456 M17688 GO_WASH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_WASH_COMPLEX.html A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. 10/11 Gene Ontology CC GO:0071203 0.1621436441025 0.168826984271599 570 444.727272727273 410 0.0159539660591318 240 0.501623438027099 0.501623438027099 1 0.144736454921129 410 567 397 443 572 375 240 396 570 573 349 457 M17401 GO_TCTN_B9D_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TCTN_B9D_COMPLEX.html A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins. 12/12 Gene Ontology CC GO:0036038 0.0216243359211568 0.0232345751119787 415 399.363636363636 411 0.00198544167977567 264 0.961656025927069 -0.627866516746337 -1 0.714900132872081 418 362 335 451 558 414 409 301 470 411 264 458 M17247 GO_SET1C_COMPASS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SET1C_COMPASS_COMPLEX.html A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. 9/11 Gene Ontology CC GO:0048188 0.000777263398302412 0.00091230309982566 370 400.272727272727 412 7.77535394482303e-05 210 0.484600780704228 0.535429076424547 1 0.667647962995792 368 412 524 259 485 303 210 459 517 552 314 459 M17297 GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX.html A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. 74/83 Gene Ontology CC GO:0070603 1.60883382098276e-05 2.7015388728063e-05 280 376.181818181818 413 1.46258689664863e-06 196 1.24534959662819 1.21946582766215 1 2.69849533443383 277 424 435 427 328 320 381 462 196 475 413 460 M17684 GO_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENVELOPE.html A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. 1138/1396 Gene Ontology CC GO:0031975 3.72095661833248e-06 8.83953535605893e-06 570 445.181818181818 413 3.72096284883033e-07 230 1.40598403971562 -1.34011853799735 -1 3.3805620698654 376 569 568 554 230 413 408 401 381 572 425 461 M17477 GO_ENDOLYSOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME_MEMBRANE.html The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. 29/50 Gene Ontology CC GO:0036020 0.00010378245111997 0.000139577787270144 580 420.181818181818 414 9.43521338729286e-06 237 1.83852951854936 1.92300497284237 1 3.37219492262257 576 469 237 398 418 546 527 318 414 333 386 462 M17822 GO_PLATELET_DENSE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE.html Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. 22/31 Gene Ontology CC GO:0042827 8.95054346454283e-05 0.000121501536282696 560 372.181818181818 414 8.13718875616142e-06 125 2.61915470526603 -3.34033298492967 -1 4.89779929971042 557 433 196 125 414 520 521 234 373 283 438 463 M17022 GO_U1_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U1_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U1. 17/22 Gene Ontology CC GO:0005685 0.0907143812988453 0.0954801730699803 420 424.636363636364 418 0.0086078315616797 188 0.580240978286916 0.581778545384708 1 0.243175217100804 231 550 418 524 545 290 188 417 574 541 393 464 M17153 GO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAJAL_BODY.html A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. 57/64 Gene Ontology CC GO:0015030 0.000121774322185714 0.000163396954249191 420 425.454545454545 420 1.10710057414609e-05 308 1.3190073979411 1.18009642098404 1 2.36397307534294 396 462 405 555 420 417 308 422 357 425 513 465 M17402 GO_PRC1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRC1_COMPLEX.html A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. 12/12 Gene Ontology CC GO:0035102 0.0169529667071212 0.0183079436000696 495 434.454545454545 421 0.0015531846758149 327 0.898164706051325 -0.97908039734302 -1 0.709707290058799 392 491 327 492 532 373 421 471 556 373 351 466 M17425 GO_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLTRANSFERASE_COMPLEX.html A protein complex that possesses methyltransferase activity. 103/119 Gene Ontology CC GO:0034708 0.000336459335884025 0.00041154289294446 390 405.090909090909 422 3.05918912427208e-05 189 1.09639790744541 1.27550140062059 1 1.74606085177546 387 422 473 411 464 432 426 326 189 528 398 467 M17699 GO_NUCLEOLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLUS.html A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. 971/1232 Gene Ontology CC GO:0005730 2.06332301505355e-05 3.39600756868587e-05 575 413.272727272727 422 2.06334217316229e-06 179 1.26752627676463 1.27237196869568 1 2.68663311399978 179 572 570 577 339 307 248 335 423 574 422 468 M17706 GO_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE.html Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. 82/99 Gene Ontology CC GO:0005643 0.000126923534280943 0.000169913763634166 125 370.181818181818 422 1.15391688554922e-05 123 0.868456732491686 0.765442111132224 1 1.53505113216799 123 458 487 533 422 220 160 325 494 523 327 469 M17066 GO_TELOMERASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_HOLOENZYME_COMPLEX.html Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. 21/23 Gene Ontology CC GO:0005697 0.000506500371838505 0.000604264303979818 535 410.909090909091 425 4.60560927020772e-05 184 0.687941354688259 0.727996462170102 1 1.02467761621921 313 533 425 516 475 265 184 373 532 503 401 470 M17385 GO_CILIARY_TRANSITION_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TRANSITION_ZONE.html A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition. 25/25 Gene Ontology CC GO:0035869 1.56660858418016e-05 2.64592903316475e-05 330 420.272727272727 425 1.42419976366347e-06 292 0.991246530236738 -0.81966458706437 -1 2.14364709208899 456 292 381 503 327 485 524 532 425 369 329 471 M17276 GO_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME.html Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. 60/70 Gene Ontology CC GO:0030684 0.00296734785914848 0.00334114167861486 130 408.272727272727 426 0.000270123434144147 126 0.75175405236591 0.795307074027237 1 0.854688165447649 126 426 486 534 511 329 301 310 524 527 417 472 M17305 GO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MATRIX.html The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. 443/496 Gene Ontology CC GO:0005759 4.65951588648812e-06 1.02559721245237e-05 335 439.818181818182 427 4.23593250472171e-07 240 1.31455255325718 -1.21429236735564 -1 3.11712486412173 334 577 502 565 240 424 427 415 378 529 447 473 M17501 GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX.html Any of the heteromeric enzymes that act in the TCA cycle. 10/13 Gene Ontology CC GO:0045239 3.05201173508761e-05 4.69105507430133e-05 435 382.272727272727 429 2.77459461436289e-06 150 1.2301855611309 1.616939749887 1 2.52311312730199 432 492 338 507 362 317 150 429 443 446 289 474 M17100 GO_MRNA_CLEAVAGE_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_FACTOR_COMPLEX.html Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. 19/20 Gene Ontology CC GO:0005849 0.00446501455479986 0.00496017869280826 520 439.727272727273 430 0.00040673657879112 346 0.780779090133513 -0.791218119373576 -1 0.824768453563762 367 537 430 551 519 346 358 385 519 473 352 475 M17232 GO_ORGANELLE_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. 527/618 Gene Ontology CC GO:0019866 3.92978007279542e-06 9.19623924505603e-06 195 407.272727272727 431 3.92978702223985e-07 193 1.20865863669584 -1.1740604414573 -1 2.89022317305385 193 494 521 536 234 369 345 364 442 551 431 476 M17435 GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX.html A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. 9/10 Gene Ontology CC GO:0031414 0.0941495322701616 0.0987380473808013 265 429.545454545455 431 0.00983937676467847 263 0.812642145167861 0.812642145167861 1 0.351664448657803 263 493 538 511 559 330 272 375 547 431 406 477 M17653 GO_TOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_COMPLEX.html A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. 15/17 Gene Ontology CC GO:0038201 0.00519832607422013 0.00575281418880362 350 465.272727272727 431 0.000473695441653959 348 0.524889154559317 -0.624658999779155 -1 0.524440557181617 348 559 411 527 521 351 401 431 580 570 419 478 M17390 GO_HISTONE_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_COMPLEX.html A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. 84/95 Gene Ontology CC GO:0035097 0.000155973596891698 0.000204100585121794 510 432.636363636364 432 1.41804232784963e-05 143 1.19700988094501 1.55141102991976 1 2.08574814112875 510 394 446 410 430 553 566 353 143 522 432 479 M17567 GO_POLYSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSOME.html A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. 45/60 Gene Ontology CC GO:0005844 4.02000381179514e-05 5.94305907036381e-05 375 427.181818181818 433 3.65461570016117e-06 261 1.08676060006159 1.19383542752079 1 2.17027753694522 371 521 463 557 375 341 261 448 433 500 429 480 M17617 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE.html The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 49/59 Gene Ontology CC GO:0098573 0.000129841380172564 0.000173420326161517 390 427.545454545455 434 1.18044585354032e-05 255 0.922317352618577 -1.19181568874241 -1 1.62891245563962 389 515 471 440 423 479 434 255 409 497 391 481 M16987 GO_90S_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_90S_PRERIBOSOME.html A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 24/28 Gene Ontology CC GO:0030686 0.0103959966261174 0.0113535226311545 455 423.454545454545 436 0.00094958635412111 284 0.593039714289088 0.595329279669045 1 0.513636465882936 284 436 452 407 527 335 337 356 533 539 452 482 M17015 GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK.html A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. 15/15 Gene Ontology CC GO:0071782 2.61683823322812e-05 4.15563410861956e-05 520 436.818181818182 436 2.37897214572959e-06 345 0.979174692535203 -0.830074764157182 -1 2.02455790954642 517 360 345 394 350 436 456 556 374 442 575 483 M17288 GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex that possesses activity that prevents or downregulates transcription. 84/99 Gene Ontology CC GO:0017053 2.20780448779261e-05 3.61333635889439e-05 440 448.090909090909 439 2.00711513133684e-06 337 1.29833614052955 1.20878723870209 1 2.73610873243501 381 456 439 520 337 428 431 562 467 472 436 484 M17563 GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR.html A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. 22/26 Gene Ontology CC GO:0030687 0.00114040527360648 0.00131463385707414 350 419.727272727273 440 0.000103726986393074 272 0.824915816050845 0.890431798545102 1 1.10291132553382 272 476 432 469 495 348 346 324 531 484 440 485 M17795 GO_HISTONE_DEACETYLASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_COMPLEX.html A protein complex that possesses histone deacetylase activity. 63/70 Gene Ontology CC GO:0000118 5.31621257449917e-05 7.62646791551609e-05 435 446.363636363636 440 4.8330373118269e-06 346 1.14100143830148 1.10148884948585 1 2.22116068289471 484 346 448 434 387 435 438 489 459 440 550 486 M17800 GO_SITE_OF_DOUBLE_STRAND_BREAK http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_DOUBLE_STRAND_BREAK.html A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. 35/46 Gene Ontology CC GO:0035861 0.000601668647388735 0.000710507081570844 440 431.909090909091 440 5.47121143835413e-05 335 1.32739597004762 1.27685126805006 1 1.97113696312163 478 467 364 437 482 374 355 504 440 335 515 487 M17018 GO_TRANSCRIPTION_EXPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_EXPORT_COMPLEX.html The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. 20/40 Gene Ontology CC GO:0000346 0.00496888526792761 0.00550939377989684 295 437.363636363636 441 0.000452740320790303 242 0.537987277956014 0.570035906682819 1 0.543439652756632 295 546 438 560 520 287 242 441 571 540 371 488 M17473 GO_INTERSTITIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTITIAL_MATRIX.html A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. 16/18 Gene Ontology CC GO:0005614 0.000224260345106815 0.000282024373391903 450 394.909090909091 441 2.03893826080942e-05 160 2.87580226367452 2.37879025372921 1 4.87525043043348 474 441 160 447 449 497 373 418 339 238 508 489 M17614 GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME.html Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. 101/110 Gene Ontology CC GO:0016591 2.12073184709809e-05 3.48063616712991e-05 385 445.272727272727 441 1.92795662779275e-06 336 1.07161625657088 1.27696139625919 1 2.25938547052684 384 504 483 567 336 431 460 344 427 521 441 490 M17226 GO_U2_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U2. 19/24 Gene Ontology CC GO:0005686 0.0686645643082629 0.0725347488420013 550 423.272727272727 444 0.00644602290518009 215 0.586769603208889 0.586769603208889 1 0.280120896825786 215 481 444 472 549 302 325 352 559 550 407 491 M17469 GO_MISMATCH_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR_COMPLEX.html Any complex formed of proteins that act in mismatch repair. 10/12 Gene Ontology CC GO:0032300 0.0100874032396349 0.0110372528855516 450 433.454545454545 447 0.000921268630472565 331 1.06752572238004 -1.15203128735219 -1 0.964451987623203 518 447 333 431 526 448 331 406 496 350 482 492 M17237 GO_PCG_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PCG_PROTEIN_COMPLEX.html A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. 50/52 Gene Ontology CC GO:0031519 2.54656122391628e-05 4.07590102230126e-05 465 398.727272727273 448 2.31508245595348e-06 247 1.0157041961071 1.14272880277254 1 2.10576768156592 318 463 455 521 347 360 448 280 485 462 247 493 M17249 GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX.html A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. 10/11 Gene Ontology CC GO:0000164 0.0588381899626423 0.0622677383757654 450 455.363636363636 448 0.00549757804634445 221 0.615461398779248 -0.606477577580474 -1 0.315518859540774 447 564 371 517 554 425 221 341 568 553 448 494 M17413 GO_SIN3_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_TYPE_COMPLEX.html Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. 20/22 Gene Ontology CC GO:0070822 0.000277592376148514 0.000343151426685717 440 447.090909090909 449 2.52388553168994e-05 373 0.936056172791951 0.882589041205694 1 1.52016534977634 463 438 413 373 457 430 507 436 451 449 501 495 M17396 GO_SAGA_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_TYPE_COMPLEX.html A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. 31/36 Gene Ontology CC GO:0070461 0.00106446469092054 0.00123198005064708 495 373.636363636364 450 9.6816370794825e-05 165 0.737776820936717 0.757168519824727 1 0.991999103631837 194 470 450 495 491 223 165 306 510 498 308 496 M17191 GO_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_COMPLEX.html A protein complex which is capable of protein kinase activity. 95/131 Gene Ontology CC GO:1902911 0.000209813216451223 0.000266160433969782 480 439.636363636364 451 1.90757480850015e-05 282 1.2575330583277 1.43938634167419 1 2.12348696301712 479 423 451 467 444 512 467 282 385 476 450 497 M17325 GO_RIBONUCLEOPROTEIN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_GRANULE.html A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. 167/225 Gene Ontology CC GO:0035770 4.88797115933172e-05 7.02948327616764e-05 520 437.727272727273 451 4.44370887627369e-06 195 1.72832809826417 1.83092651208696 1 3.41555146918634 516 451 394 519 385 494 407 397 195 489 568 498 M17102 GO_NUCLEOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLAR_PART.html Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. 60/65 Gene Ontology CC GO:0044452 0.000230177674340741 0.000288218165499936 120 378.272727272727 452 2.09274327716235e-05 119 0.77873748584769 0.812071779681791 1 1.28605040458498 119 461 476 556 452 248 190 260 526 516 357 499 M17292 GO_EXON_EXON_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXON_EXON_JUNCTION_COMPLEX.html A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. 26/51 Gene Ontology CC GO:0035145 0.00786227838932108 0.0086679008428758 440 457.727272727273 453 0.000717319790764757 303 0.694654114730375 0.586313473115909 1 0.648051831337363 438 435 453 446 523 410 303 480 537 514 496 500 M17650 GO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. 147/223 Gene Ontology CC GO:0000781 0.000368180485440429 0.000447516447784287 185 370.181818181818 453 3.34765560581749e-05 140 1.13518537995976 1.04000631337593 1 1.78941474872393 183 453 485 570 468 204 140 237 479 513 340 501 M16976 GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. 117/187 Gene Ontology CC GO:0000784 0.00052826822135691 0.000626375176751764 480 371.818181818182 454 4.80359193450085e-05 171 1.13690975372401 0.982849073674491 1 1.71222811885788 187 454 474 566 478 209 171 222 478 510 341 502 M17061 GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 247/294 Gene Ontology CC GO:0061695 8.06409143209435e-06 1.54662644881993e-05 425 437.727272727273 454 7.33101908285616e-07 282 1.22435868332552 1.26174082857879 1 2.79515845676617 423 496 489 563 282 447 466 327 344 524 454 503 M17380 GO_DNA_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR_COMPLEX.html A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 40/43 Gene Ontology CC GO:1990391 0.000478202802523502 0.000576422880220237 520 397.636363636364 454 4.34824344250179e-05 261 1.02035110250239 1.03004802131439 1 1.5501268897881 324 520 457 518 473 288 291 261 477 454 311 504 M17586 GO_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MEMBRANE.html The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. 205/257 Gene Ontology CC GO:0019867 3.52904313648891e-05 5.29812419198981e-05 455 453.090909090909 454 3.2082724977385e-06 332 1.62417631530567 -1.36954709588238 -1 3.30327072217225 470 579 441 552 370 381 454 463 332 491 451 505 M17360 GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX.html Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. 30/41 Gene Ontology CC GO:0005834 0.000264976250701668 0.000328254161316992 580 452.636363636364 455 2.4091651892508e-05 285 1.67773254842338 1.87686585917179 1 2.77345838032673 577 471 285 429 455 532 436 482 369 383 560 506 M17576 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE.html The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 21/24 Gene Ontology CC GO:0031304 0.000210680157408299 0.000266677933451463 500 462.090909090909 455 1.91545759660623e-05 371 0.78838488893376 0.559044272650349 1 1.31531287387185 496 437 414 455 445 536 450 371 480 504 495 507 M17643 GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX.html Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. 134/172 Gene Ontology CC GO:0031461 1.14394824228847e-05 2.02016391723283e-05 455 462.818181818182 455 1.039958355085e-06 310 1.58593366236605 1.88927093246782 1 3.54438632512961 547 452 410 544 310 554 571 455 323 436 489 508 M17146 GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX.html A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. 13/13 Gene Ontology CC GO:0043240 0.000278349975485306 0.000343357400757883 540 437.181818181818 458 2.53077453926962e-05 213 0.976343403789861 -0.925257573339736 -1 1.58727445415622 462 445 359 545 458 333 213 538 534 386 536 509 M17543 GO_NADH_DEHYDROGENASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX.html An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. 45/51 Gene Ontology CC GO:0030964 0.294916987885655 0.304584122304504 170 428.272727272727 460 0.0312679704946824 168 0.880513002945248 -0.892057373855815 -1 0.177042755926933 168 524 481 380 568 366 263 447 536 518 460 510 M17155 GO_TRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX.html A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). 713/832 Gene Ontology CC GO:1990234 1.01279802156218e-05 1.83941640207471e-05 445 464.272727272727 461 1.01280263751103e-06 306 1.22428761605727 1.32403849728341 1 2.75059086129771 443 573 518 576 306 454 461 395 358 547 476 511 M17502 GO_STAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAGA_COMPLEX.html A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. 15/17 Gene Ontology CC GO:0030914 0.014100335638278 0.0152841324735811 465 445.818181818182 461 0.00129013885798156 309 0.623544254459609 0.578932524872766 1 0.503435050882738 419 484 408 462 530 364 309 349 552 566 461 512 M17711 GO_NUCLEAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE.html Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. 311/392 Gene Ontology CC GO:0031965 4.17486208534649e-06 9.54958610860753e-06 565 467.909090909091 461 3.7953363707777e-07 231 1.47332387243045 -1.50793525750376 -1 3.52066964216441 565 449 461 546 231 558 563 546 406 447 375 513 M17797 GO_U12_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U12_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. 29/35 Gene Ontology CC GO:0005689 0.00237656959336806 0.00269684947997431 530 377.454545454545 464 0.00021628552666042 123 0.632311594233474 0.641573175884064 1 0.740565674234739 134 528 464 530 507 198 123 284 560 515 309 514 M17415 GO_SMALL_SUBUNIT_PROCESSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_SUBUNIT_PROCESSOME.html A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 32/36 Gene Ontology CC GO:0032040 0.00916544948195821 0.0100474078283353 525 403.636363636364 465 0.000836714362847622 136 0.750530173118966 0.783598229482502 1 0.680364375947728 136 472 465 528 525 319 259 313 525 517 381 515 M17495 GO_RESPIRATORY_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN.html The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. 76/93 Gene Ontology CC GO:0070469 0.440694057828278 0.45078036548984 145 433.181818181818 466 0.0514525968581913 145 0.729202052277878 -0.729989638391865 -1 0.0796106517124856 145 513 497 381 569 355 315 451 539 534 466 516 M17780 GO_PROTEASOME_ACCESSORY_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ACCESSORY_COMPLEX.html A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. 25/28 Gene Ontology CC GO:0022624 0.424999849235244 0.435493672673152 440 466.818181818182 466 0.0490632476255523 346 0.643329554454001 -0.736123482527693 -1 0.069940421873955 346 532 466 496 575 439 396 437 516 512 420 517 M17475 GO_CYTOPLASMIC_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_DYNEIN_COMPLEX.html Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. 23/29 Gene Ontology CC GO:0005868 0.000312127604414097 0.000383395640939937 470 456.454545454545 467 2.83792633350321e-05 314 1.31718731352144 0.977535832572318 1 2.1256431693575 511 474 349 460 462 507 314 468 455 467 554 518 M16994 GO_RETROMER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROMER_COMPLEX.html A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. 23/25 Gene Ontology CC GO:0030904 0.000171609030821119 0.000222555461846139 580 482.545454545455 468 1.5602038044727e-05 335 0.957357014132639 0.939383989280194 1 1.64242966125077 580 473 426 335 434 568 419 577 468 466 562 519 M17039 GO_CYTOPLASMIC_STRESS_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_STRESS_GRANULE.html A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. 36/44 Gene Ontology CC GO:0010494 0.00020106640598612 0.000256746333797661 470 481.272727272727 468 1.82804349604386e-05 372 1.07009506443083 -1.41778906396002 -1 1.80878774103782 539 468 434 463 442 572 568 372 463 470 503 520 M17048 GO_OXIDOREDUCTASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_COMPLEX.html Any protein complex that possesses oxidoreductase activity. 90/106 Gene Ontology CC GO:1990204 0.543479101014469 0.554940874673825 510 454 468 0.068802334518028 282 1.23900364135953 -1.0943333032196 -1 0.11070339853141 282 508 484 531 576 397 349 450 441 508 468 521 M17028 GO_NUCLEOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOID.html The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. 64/68 Gene Ontology CC GO:0009295 0.00037538746028225 0.000455323829695172 445 477.909090909091 469 3.41319571090019e-05 444 0.936441531044802 0.96340268042475 1 1.46540134423366 444 460 472 445 469 444 553 486 521 506 457 522 M17188 GO_NUCLEAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_BODY.html Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. 396/505 Gene Ontology CC GO:0016604 0.000141624080284711 0.000186865238747785 500 454.272727272727 469 1.28757452815837e-05 298 1.39348713841096 1.41897440838432 1 2.46070422320875 320 578 498 575 426 390 298 469 410 536 497 523 M17458 GO_MITOCHONDRIAL_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_PART.html Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. 170/199 Gene Ontology CC GO:0044455 0.259600966003202 0.268855902402603 345 461.363636363636 469 0.0269542536154004 344 1.0180809719827 -1.05505001024531 -1 0.237828068594415 344 499 503 382 579 469 424 408 450 537 480 524 M17317 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX.html A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. 24/31 Gene Ontology CC GO:0097526 0.0471663361033296 0.0500066446642966 565 481.727272727273 474 0.00438263447061213 340 0.585683880289284 0.526486888090759 1 0.325091875176605 340 539 459 562 542 393 403 470 563 554 474 525 M16996 GO_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_COMPLEX.html A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. 77/87 Gene Ontology CC GO:0000502 0.0203393051788367 0.0219241861018629 90 386.454545454545 476 0.00186634684499649 89 0.82786609884894 -0.919430083665326 -1 0.619659633366391 89 512 495 535 560 250 228 296 476 519 291 526 M17526 GO_U2_TYPE_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. 15/18 Gene Ontology CC GO:0071004 0.590040965586471 0.599324826933112 570 485.636363636364 477 0.0778648274620915 335 0.475087140285628 0.443110995147451 1 0.00894747629613825 380 562 415 473 570 406 335 578 579 567 477 527 M17724 GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX.html Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. 47/50 Gene Ontology CC GO:0008023 0.000153937027404986 0.000201890322623694 450 492.272727272727 477 1.39952545132625e-05 429 0.728055827372242 -0.771630644903895 -1 1.25384222141148 446 518 477 561 429 456 552 475 523 511 467 528 M16993 GO_NUCLEAR_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE.html The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). 452/592 Gene Ontology CC GO:0005635 3.96292723965966e-06 9.20984290496905e-06 565 456.090909090909 479 3.60266761656329e-07 226 1.46876846764975 -1.48957230995767 -1 3.52078473770658 562 417 479 487 226 548 531 545 366 461 395 529 M17417 GO_EXTERNAL_ENCAPSULATING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_ENCAPSULATING_STRUCTURE.html A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space. 8/13 Gene Ontology CC GO:0030312 0.000502384814298759 0.000603024964897825 545 436.363636363636 479 5.02498426174853e-05 213 2.50026594692862 2.82836388557359 1 3.83564871098339 542 448 536 294 479 577 502 551 213 327 331 530 M17546 GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX.html RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 20/22 Gene Ontology CC GO:0005665 0.0416717026091562 0.0442618998462884 545 481.454545454545 479 0.00386205657760221 401 0.792613003533706 0.9758096167618 1 0.475000142245592 401 542 419 522 541 459 540 421 529 479 443 531 M16978 GO_CLATHRIN_SCULPTED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_SCULPTED_VESICLE.html A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. 17/26 Gene Ontology CC GO:0060198 0.00229460767145853 0.00260893748946655 515 423.818181818182 480 0.00020881858688985 219 1.99234940526732 1.51439786823812 1 2.43745324111432 515 442 219 244 505 499 480 377 527 331 523 532 M17089 GO_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME.html An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. 235/339 Gene Ontology CC GO:0005840 6.9813448688859e-05 9.63458757440074e-05 500 479.909090909091 481 6.34687856403516e-06 364 0.75262595184314 -0.820484176909528 -1 1.41404582139331 364 498 500 580 402 450 462 435 561 546 481 533 M17583 GO_ORGANELLE_ENVELOPE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ENVELOPE_LUMEN.html The region between the inner and outer lipid bilayers of an organelle envelope. 95/115 Gene Ontology CC GO:0031970 9.49439249540308e-05 0.000128284698600679 470 483 481 8.6316384211747e-06 416 1.31600776609163 -1.44292735559923 -1 2.42510524118824 466 505 467 526 416 524 512 446 481 453 517 534 M17441 GO_ENDORIBONUCLEASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_COMPLEX.html A protein complex which is capable of endoribonuclease activity. 21/22 Gene Ontology CC GO:1902555 0.00328792828778473 0.00368781145792071 515 467.727272727273 482 0.000299350222261338 338 0.790603667649388 -0.786543043822228 -1 0.884696983640544 514 440 406 458 512 437 338 502 530 482 526 535 M17047 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE.html The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 21/28 Gene Ontology CC GO:0031306 0.154993179932173 0.161671521616862 435 483.818181818182 483 0.0151934497457929 431 0.701740773177924 -0.727548779489707 -1 0.225563790019478 506 530 431 442 550 511 476 432 503 458 483 536 M17388 GO_U5_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U5_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U5. 16/20 Gene Ontology CC GO:0005682 0.0086540779229135 0.00952276377502414 430 487.545454545455 484 0.000789846262616172 422 0.554589150814598 0.459275469946789 1 0.49801602676318 422 549 427 523 524 429 430 484 548 556 471 537 M17436 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_.html All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. 11/16 Gene Ontology CC GO:0045263 0.295147781165982 0.304584122304504 370 460.090909090909 485 0.0312968014151555 264 0.819077472470632 -0.819077472470632 -1 0.161764290787479 366 565 387 378 567 421 264 485 576 559 493 538 M17382 GO_SIN3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_COMPLEX.html A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. 17/19 Gene Ontology CC GO:0016580 0.00547062508160342 0.00604264861675206 485 480.181818181818 486 0.000498570558771044 377 0.774965341760933 0.90344180368533 1 0.786312760381185 483 543 422 377 522 495 579 399 518 486 458 539 M17808 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX.html A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. 22/28 Gene Ontology CC GO:0045259 0.683421029147642 0.68618940391 410 485.272727272727 486 0.0992810943904768 357 0.532260964290027 -0.57915178196564 -1 0 407 486 456 379 571 475 357 521 578 581 527 540 M17104 GO_INO80_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INO80_TYPE_COMPLEX.html A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. 23/26 Gene Ontology CC GO:0097346 5.34015134439426e-05 7.64194071697799e-05 490 479.090909090909 487 4.8548008841002e-06 388 0.715893680451233 -0.722195170167553 -1 1.37768674278478 537 403 428 438 388 491 489 541 487 487 581 541 M17218 GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT.html The small subunit of a ribosome located in the cytosol. 47/76 Gene Ontology CC GO:0022627 0.68618940391 0.68618940391 490 482.545454545455 487 0.1 403 1.139300708796 -1.3515642831352 -1 0.0478241967560698 403 529 478 412 563 463 420 490 543 520 487 542 M17578 GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). 33/36 Gene Ontology CC GO:0000315 0.381189532050552 0.391984279860833 330 473.727272727273 488 0.0426941880023266 328 0.743019617934348 -0.795823306126147 -1 0.103637121403942 328 526 470 553 566 434 370 427 542 507 488 543 M17120 GO_NUCLEAR_SPECK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_SPECK.html A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. 232/306 Gene Ontology CC GO:0016607 0.000481414009417025 0.000579092214226277 440 497.818181818182 490 4.3774489718649e-05 385 1.35543854662211 1.44961187998471 1 2.07165575111025 437 580 490 573 474 484 385 529 431 535 558 544 M17178 GO_PRECATALYTIC_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRECATALYTIC_SPLICEOSOME.html A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. 22/27 Gene Ontology CC GO:0071011 0.122452566092342 0.128189082702074 560 475.636363636364 490 0.0118047048173092 342 0.623161227176774 0.561675843152085 1 0.225861722202755 342 538 449 559 548 382 376 443 557 548 490 545 M17577 GO_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_COMPLEX.html Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. 35/52 Gene Ontology CC GO:0030286 2.69308050211105e-05 4.25184720577859e-05 525 449.363636363636 491 2.44828497219554e-06 296 1.71445653993112 -1.84613042260979 -1 3.5681181460187 522 523 296 491 353 501 550 570 336 417 384 546 M17248 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY.html A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. 71/84 Gene Ontology CC GO:0000932 0.00254121119305258 0.0028780579009036 510 487.727272727273 492 0.000231286481051191 401 1.28641022106092 -1.27951994968887 -1 1.53252562897555 492 459 447 470 508 537 576 509 401 502 464 547 M17781 GO_CYTOSOLIC_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_RIBOSOME.html A ribosome located in the cytosol. 124/214 Gene Ontology CC GO:0022626 0.392657028169199 0.403063133156015 510 494.727272727273 492 0.0443206924145226 402 0.834466046610984 -0.956417399560139 -1 0.116687633520732 402 510 509 414 556 468 492 460 566 579 486 548 M17846 GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX.html A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. 61/70 Gene Ontology CC GO:0030532 0.0133237821347295 0.0144693783556595 495 477.909090909091 492 0.00121865139602511 341 0.699711157874238 0.620624162566642 1 0.578071118637899 341 517 492 572 529 395 371 458 558 532 492 549 M17221 GO_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIGASE_COMPLEX.html A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. 256/305 Gene Ontology CC GO:0000151 6.56372550027577e-06 1.32875418664119e-05 535 469.727272727273 495 5.96704098482608e-07 266 1.32911882593086 1.50415794303095 1 3.08012577723254 534 495 488 549 266 418 532 579 391 505 410 550 M17429 GO_NUCLEOPLASM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPLASM_PART.html Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. 746/883 Gene Ontology CC GO:0044451 4.76258507026617e-05 6.88323862145434e-05 370 465.909090909091 495 4.7626871433195e-06 328 1.21756867950497 1.26368362198444 1 2.39914283459848 370 574 537 579 386 396 328 495 405 557 498 551 M17339 GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT.html The large subunit of a ribosome located in the cytosol. 69/129 Gene Ontology CC GO:0022625 0.637374383866097 0.64627315362339 490 515 496 0.0880925350715279 475 0.532299047209265 -0.483028014058443 -1 0.00667657886504269 490 519 496 475 562 486 488 481 581 555 532 552 M17286 GO_ORGANELLAR_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_RIBOSOME.html A ribosome contained within a subcellular membrane-bounded organelle. 71/80 Gene Ontology CC GO:0000313 0.569533851877334 0.57950817502755 500 486.090909090909 497 0.0737638486793332 323 0.72139212250533 -0.766280714671242 -1 0.0404002118130847 323 514 494 497 565 481 445 457 546 525 500 553 M17497 GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX.html A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. 19/24 Gene Ontology CC GO:0046540 0.0243825436942755 0.0261370071704319 410 499.727272727273 498 0.00224154941373123 406 0.60432408557573 0.541474329772932 1 0.418795189072805 406 548 436 529 534 464 498 473 553 565 491 554 M17422 GO_MLL1_2_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MLL1_2_COMPLEX.html A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. 31/35 Gene Ontology CC GO:0044665 0.000183662231678799 0.000236602564535216 550 500.181818181818 499 1.66979605558541e-05 400 0.753388042325465 -0.762109692037261 -1 1.27392284693072 549 400 462 405 437 580 574 569 488 499 539 555 M17542 GO_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX.html Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. 190/251 Gene Ontology CC GO:0005681 0.00148348495185434 0.00170336908503433 500 442.909090909091 499 0.000134953293450076 195 0.804906760621287 0.682426044783153 1 1.03152295198064 195 497 506 539 499 324 250 512 512 568 470 556 M17539 GO_DNA_HELICASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_COMPLEX.html A protein complex that possesses DNA helicase activity. 15/18 Gene Ontology CC GO:0033202 0.000143869158535706 0.000189113079432682 385 489.272727272727 500 1.30798697937408e-05 384 0.70377010060352 -0.738641790708337 -1 1.22024454378928 569 384 384 436 427 562 572 552 500 444 552 557 M17087 GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX.html The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. 13/15 Gene Ontology CC GO:0008540 0.68618940391 0.68618940391 420 497.090909090909 501 0.1 408 0.693877007924747 -0.693877007924747 -1 0.0127325394089553 464 566 420 408 577 513 418 501 562 545 494 558 M17258 GO_CYTOSOLIC_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PROTEASOME_COMPLEX.html A proteasome complex found in the cytosol of a cell. 13/14 Gene Ontology CC GO:0031597 0.68618940391 0.68618940391 500 493.545454545455 502 0.1 336 0.740520395976363 -0.876730429495364 -1 0.0164072288963225 499 560 417 336 581 540 479 533 502 468 514 559 M17498 GO_PRP19_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRP19_COMPLEX.html A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. 19/20 Gene Ontology CC GO:0000974 0.00440919200728967 0.00490754895830517 555 471.818181818182 503 0.000401641244387029 245 0.854644124016192 0.791577723195639 1 0.908669239610101 552 407 355 245 518 503 463 544 549 474 580 560 M17748 GO_MITOCHONDRIAL_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PROTEIN_COMPLEX.html A protein complex that is part of a mitochondrion. 133/156 Gene Ontology CC GO:0098798 0.68618940391 0.68618940391 580 482.363636363636 503 0.1 339 0.749223470465384 -0.744182628645499 -1 0.0170928801251138 339 503 508 383 578 460 410 491 544 578 512 561 M17210 GO_OUTER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the outer mitochondrial membrane. 11/12 Gene Ontology CC GO:0098799 0.568451575425947 0.579421693548203 565 496.272727272727 504 0.0735523866293476 388 0.630006796385395 0.42630917261811 1 0.0299899908329595 487 561 388 404 561 504 439 554 545 457 559 562 M17241 GO_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of a ribosome. 70/104 Gene Ontology CC GO:0015935 0.68618940391 0.68618940391 410 496.272727272727 504 0.1 409 0.925777894139816 -1.00111488068253 -1 0.031002304627182 409 522 493 413 564 490 470 510 551 533 504 563 M17461 GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the inner mitochondrial membrane. 105/124 Gene Ontology CC GO:0098800 0.68618940391 0.68618940391 335 472.909090909091 504 0.1 327 0.738538910955544 -0.740963667270308 -1 0.0162511222651464 335 509 504 327 574 453 394 498 550 538 520 564 M17484 GO_CATALYTIC_STEP_2_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_STEP_2_SPLICEOSOME.html A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. 103/158 Gene Ontology CC GO:0071013 0.0036169294381373 0.00404122308376494 225 438.363636363636 505 0.000329353600533627 211 0.645375724968585 0.653647663456076 1 0.702126850298919 224 507 505 537 514 331 211 411 555 562 465 565 M17590 GO_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SUBUNIT.html Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. 175/272 Gene Ontology CC GO:0044391 0.0151411635831078 0.0163817803385207 505 499.727272727273 505 0.00138603505244561 386 0.724270659437362 -0.787103484111098 -1 0.581024873367696 386 502 507 541 531 465 449 477 565 569 505 566 M17053 GO_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). 105/168 Gene Ontology CC GO:0015934 0.00349696845770504 0.00391471806151566 515 492.545454545455 506 0.000318412672644656 411 0.613094254084285 -0.648625521623698 -1 0.668988281879381 411 511 499 540 513 449 433 439 575 542 506 567 M17630 GO_INTEGRATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRATOR_COMPLEX.html A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. 14/14 Gene Ontology CC GO:0032039 0.000351711158299533 0.000428394513568194 545 486.454545454545 507 3.19788544087255e-05 336 0.775670728849991 -0.692258577568449 -1 1.21651054176692 543 552 382 547 465 496 336 543 507 434 546 568 M17207 GO_CCR4_NOT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR4_NOT_COMPLEX.html The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins. 18/18 Gene Ontology CC GO:0030014 0.04095706322523 0.0435825159960781 540 499.454545454545 509 0.00379454903982215 413 0.904047651032413 -0.510395354675872 -1 0.550601896312662 579 545 416 466 540 538 509 413 508 464 516 569 M17672 GO_RNAI_EFFECTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNAI_EFFECTOR_COMPLEX.html Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. 11/11 Gene Ontology CC GO:0031332 0.00022995320354972 0.000288218165499936 515 514.181818181818 514 2.09070220671244e-05 380 0.560636867567358 -0.568520427633535 -1 0.9141227770178 504 558 380 513 451 514 551 581 564 571 469 570 M17127 GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinase (CDK) complex found in the nucleus. 16/20 Gene Ontology CC GO:0019908 0.226179288861839 0.234661012194158 560 501.090909090909 523 0.023040871073975 409 0.631478424468453 -0.715889132878284 -1 0.149562802391644 523 556 424 409 552 579 446 442 541 483 557 571 M17579 GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX.html A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. 23/27 Gene Ontology CC GO:0032806 0.0388438964965607 0.0414097318614712 535 515.181818181818 525 0.00359519852335197 442 0.765790223459299 0.848397906882917 1 0.468177184250478 570 534 442 525 539 564 465 500 506 488 534 572 M17114 GO_CYTOSOLIC_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PART.html Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. 219/339 Gene Ontology CC GO:0044445 7.14976823329368e-06 1.4235291358124e-05 505 506.909090909091 526 6.49981042672086e-07 271 1.16605965645101 -1.12973395375244 -1 2.68029859919687 502 581 501 538 271 510 526 573 504 530 540 573 M17739 GO_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX.html A macromolecular complex containing both protein and RNA molecules. 755/991 Gene Ontology CC GO:1990904 5.97618689533197e-05 8.38687098113014e-05 580 514.727272727273 526 5.97634761805936e-06 399 1.04941483029873 1.03305046274213 1 2.01864048345791 465 576 572 581 399 498 453 526 452 576 564 574 M17478 GO_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. 20/24 Gene Ontology CC GO:0071010 0.32578968410992 0.335609585935928 555 503.090909090909 529 0.0352029989676691 367 0.471767986371354 0.441473805860019 1 0.0658184051289581 477 551 437 474 555 466 367 540 577 561 529 575 M17431 GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of an organellar ribosome. 24/29 Gene Ontology CC GO:0000314 0.68618940391 0.68618940391 545 528.454545454545 532 0.1 460 0.606644585804505 -0.624661257049328 -1 0.005860138455403 501 541 460 532 580 523 485 524 567 558 542 576 M17071 GO_U2_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. 32/43 Gene Ontology CC GO:0005684 0.0939532610681851 0.098710388210878 535 536.454545454545 533 0.00892938376754445 475 0.49787962302686 0.450939610759365 1 0.199240666258169 533 531 475 568 546 525 518 525 573 544 563 577 M17571 GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX.html RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 19/21 Gene Ontology CC GO:0005666 8.36563381308583e-05 0.000113827476473135 540 508.909090909091 535 7.60541085303244e-06 409 0.735992884835202 -0.642970127687988 -1 1.35619660141054 546 540 421 468 409 506 537 575 535 494 567 578 M17745 GO_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_PREINITIATION_COMPLEX.html A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. 16/16 Gene Ontology CC GO:0070993 0.0299497643855383 0.0319867888014665 575 517.818181818182 541 0.00276049367741372 299 0.415441173478986 -0.456185078883427 -1 0.257240733097289 574 555 440 299 537 541 486 537 572 577 578 579 M17206 GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX.html A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. 17/18 Gene Ontology CC GO:0005852 0.0743243704063043 0.0783710693394969 570 519 544 0.00699644626432241 338 0.575084732451095 -0.456185078883427 -1 0.264397326794561 573 554 445 338 544 526 506 539 569 549 566 580 M17467 GO_CATALYTIC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_COMPLEX.html A protein complex which is capable of catalytic activity. 1033/1220 Gene Ontology CC GO:1902494 7.87872137534175e-06 1.53088806511583e-05 545 507.545454545455 545 7.87874930889385e-07 290 1.28534001871179 1.3981281017837 1 2.93921495223004 512 570 542 578 290 545 549 507 377 560 553 581 M17167 GO_PORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX.html Any small opening in a membrane that allows the passage of gases and/or liquids. 16/21 Gene Ontology CC GO:0046930 0.164540968918481 0.171016642113842 550 493.363636363636 548 0.0162102642475392 263 1.86239757874604 -1.66108267386468 -1 0.64610143782456 548 553 263 548 557 574 558 391 509 378 548