Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M17752 GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. 19/23 Gene Ontology CC GO:0033176 2.32978916303537e-07 2.55397642211991e-06 10 86 9 2.11799037250812e-08 2 1.50708009848124 -1.50708009848124 -1 4.58646636773856 6 88 236 228 33 9 2 2 7 331 4 2 M17156 GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PROTON_TRANSPORTING_V_TYPE_ATPASE_COMPLEX.html A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. 12/15 Gene Ontology CC GO:0016471 1.76189227629964e-07 2.04731882506018e-06 5 99.6363636363636 17 1.60172037945689e-08 1 1.60030332596143 -1.60030332596143 -1 4.95997125432033 9 238 222 187 94 17 3 1 4 319 2 3 M17598 GO_MICROTUBULE_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_END.html Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. 27/27 Gene Ontology CC GO:1990752 3.59174789095313e-06 1.04340276232188e-05 30 77.1818181818182 38 3.26523068627243e-07 15 1.91502332356953 1.71981175111798 1 5.20118084741183 28 67 165 32 179 38 15 46 24 227 28 4 M17391 GO_MICROTUBULE_PLUS_END http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_PLUS_END.html The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. 22/22 Gene Ontology CC GO:0035371 1.78963145839606e-06 7.65586034975779e-06 45 69.1818181818182 45 1.6269390129156e-07 19 1.98325298615533 1.76719367590302 1 5.53678335015715 45 75 151 30 97 43 19 70 19 182 30 5 M17227 GO_ACTIN_FILAMENT_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE.html An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. 83/106 Gene Ontology CC GO:0032432 6.33551509415354e-06 1.50857961873082e-05 30 65.5454545454545 49 5.75957576283104e-07 19 2.47316081523936 2.59714871919689 1 6.5204528469558 27 19 61 76 223 33 72 27 49 96 38 6 M17433 GO_CELL_CELL_ADHERENS_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHERENS_JUNCTION.html An adherens junction which connects a cell to another cell. 68/93 Gene Ontology CC GO:0005913 1.44017574816046e-08 1.9459118829796e-07 15 104.636363636364 49 1.30925068871656e-09 11 2.82821172212447 3.30140470684063 1 10.4242772944255 154 21 31 11 49 201 379 186 15 44 60 7 M17676 GO_NEUROMUSCULAR_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION.html The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. 91/122 Gene Ontology CC GO:0031594 7.4980142185061e-09 1.08908656523801e-07 30 90.7272727272727 51 6.81637658550978e-10 11 2.50456404973477 2.81290802747522 1 9.57184065215186 19 11 29 158 203 29 148 160 169 51 21 8 M17707 GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AP_TYPE_MEMBRANE_COAT_ADAPTOR_COMPLEX.html Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). 42/45 Gene Ontology CC GO:0030119 1.56988803152869e-05 2.84144843089773e-05 55 156.272727272727 57 1.42718112193953e-06 6 1.25362396242629 -1.31216822799254 -1 3.07640462196035 57 52 323 196 302 35 54 48 232 414 6 9 M17217 GO_INTERMEDIATE_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT.html A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. 81/224 Gene Ontology CC GO:0005882 2.25690917919432e-13 5.96029196869045e-12 35 96.6363636363636 58 2.05173561744959e-14 15 3.30487915712519 3.64303863943166 1 20.4480877267782 95 16 15 58 164 31 49 320 102 33 180 10 M17548 GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 17/20 Gene Ontology CC GO:0000780 1.70330558834016e-05 3.0496767763799e-05 95 87.6363636363636 59 1.54847161452979e-06 4 2.8044962012303 2.93894338757449 1 6.93001051613052 7 92 90 123 391 19 4 54 33 92 59 11 M17560 GO_INTRACILIARY_TRANSPORT_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE.html A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. 35/39 Gene Ontology CC GO:0030990 1.33955024526721e-06 7.1326376758392e-06 15 145.545454545455 60 1.21777369172903e-07 12 1.57234204097655 1.50487492592292 1 4.40038194227353 12 267 264 310 60 14 26 31 314 252 51 12 M17336 GO_CONTRACTILE_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_FIBER.html Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. 205/299 Gene Ontology CC GO:0043292 2.57556337255491e-08 3.18383472224341e-07 25 89.6363636363636 62 2.34142127518845e-09 22 2.39168167658857 2.58454698024689 1 8.52044405687052 62 182 35 152 24 39 241 22 116 71 42 13 M17516 GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_OUTER_KINETOCHORE.html The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. 14/14 Gene Ontology CC GO:0000940 4.02887968273314e-06 1.13094729371803e-05 5 78.0909090909091 63 3.66262460079587e-07 1 2.91605035309241 2.91605035309241 1 7.90381819068782 3 97 64 121 338 23 1 36 37 76 63 14 M17201 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_COMPLEX.html A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. 32/56 Gene Ontology CC GO:0008328 1.56756800124559e-06 7.17131502932038e-06 50 106.545454545455 65 1.42506283471578e-07 24 2.81056746116713 2.64370258334308 1 7.92278261272552 65 55 47 96 258 49 24 158 234 41 145 15 M17284 GO_ACTOMYOSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN.html Any complex of actin, myosin, and accessory proteins. 93/116 Gene Ontology CC GO:0042641 4.53857413661603e-06 1.22647049924368e-05 70 80.6363636363636 67 4.12598499969832e-07 13 2.36474134242883 2.58099207335736 1 6.34886498331818 67 13 73 82 218 57 129 19 38 139 52 16 M17059 GO_LATE_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a late endosome. 110/129 Gene Ontology CC GO:0031902 1.47317817745388e-06 7.1326376758392e-06 25 142.181818181818 68 1.33925378539443e-07 5 1.33140694753702 -1.18227105289307 -1 3.7142791637314 22 8 359 394 73 13 68 56 202 364 5 17 M17381 GO_CLATHRIN_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_VESICLE_COAT.html A clathrin coat found on a vesicle. 29/32 Gene Ontology CC GO:0030125 3.14184578181187e-06 9.70964042145052e-06 70 114.818181818182 70 2.85622751702511e-07 28 1.63741563657655 -1.89516007875813 -1 4.46433212375883 68 70 251 55 165 117 56 43 28 338 72 18 M17058 GO_INTERCALATED_DISC http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCALATED_DISC.html A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. 70/108 Gene Ontology CC GO:0014704 1.40434673663947e-06 7.1326376758392e-06 25 83.1818181818182 72 1.2766796664456e-07 23 2.62103632886018 2.81218864179061 1 7.38671346619823 111 25 44 23 139 82 156 39 72 50 174 19 M17465 GO_APICOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICOLATERAL_PLASMA_MEMBRANE.html The apical end of the lateral plasma membrane of epithelial cells. 23/27 Gene Ontology CC GO:0016327 3.40803279921065e-07 3.41390871782998e-06 10 97 72 3.09821211559192e-08 4 3.51174227960284 -4.18384438236003 -1 10.5449119580379 137 72 55 10 279 209 131 4 9 116 45 20 M17452 GO_SPINDLE_MIDZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MIDZONE.html The area in the center of the spindle where the spindle microtubules from opposite poles overlap. 29/32 Gene Ontology CC GO:0051233 1.08468483452927e-05 2.15822564678598e-05 50 96.9090909090909 74 9.86081984073351e-07 45 2.03080464982235 2.3338009374103 1 5.16563566873668 46 63 129 129 270 48 51 45 98 113 74 21 M17271 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. 22/48 Gene Ontology CC GO:0034364 5.60513376732126e-06 1.39170201658703e-05 225 107.363636363636 77 5.0955891346047e-07 13 3.88821516165756 -4.07302354129382 -1 10.3706943890041 222 77 60 13 212 192 67 146 23 107 62 22 M16979 GO_I_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_BAND.html A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. 134/198 Gene Ontology CC GO:0031674 2.43839860619448e-07 2.62353627814628e-06 85 99.5454545454545 79 2.21672625132509e-08 10 2.49920063334392 2.87499005815453 1 7.64040029414851 81 208 39 204 51 45 237 13 128 79 10 23 M17008 GO_CELL_CELL_CONTACT_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_CONTACT_ZONE.html Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. 83/126 Gene Ontology CC GO:0044291 2.92377774934902e-06 9.2988912839913e-06 175 113.909090909091 80 2.65798330457028e-07 17 2.48183493423048 2.73292674876219 1 6.83214953252767 173 17 49 26 154 161 249 64 80 55 225 24 M17029 GO_KINESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINESIN_COMPLEX.html Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. 51/57 Gene Ontology CC GO:0005871 3.35236128648363e-06 1.00324591598972e-05 80 89.5454545454545 81 3.04760581347692e-07 8 2.14028568698003 2.66186096843986 1 5.84224708964809 78 39 123 181 175 81 75 15 108 102 8 25 M17437 GO_CONNEXON_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNEXON_COMPLEX.html An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. 7/20 Gene Ontology CC GO:0005922 5.60987668523035e-05 8.4754695346622e-05 85 154.363636363636 83 5.61001830848605e-06 47 4.08990469472223 3.99883374198812 1 9.13711686983602 61 113 539 83 377 69 47 78 83 93 155 26 M17848 GO_VACUOLAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_MEMBRANE.html The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. 648/795 Gene Ontology CC GO:0005774 1.18973873160977e-06 6.94007103560441e-06 60 155 83 1.18973936857546e-07 2 1.61008252350649 -1.47749570638867 -1 4.518443101676 31 141 581 186 57 2 83 58 197 360 9 27 M17754 GO_PROTEIN_LIPID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX.html A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. 33/64 Gene Ontology CC GO:0032994 4.53397979771398e-06 1.22647049924368e-05 85 115.454545454545 85 4.12180831074499e-07 16 3.12079323922779 -3.12749380050291 -1 8.40337337903929 219 57 84 16 192 183 85 193 35 141 65 28 M17622 GO_ENDOSOMAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOMAL_PART.html Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. 481/614 Gene Ontology CC GO:0044440 1.62170112768875e-06 7.24775657836278e-06 40 139 86 1.47427483918698e-07 7 1.61896682092309 -1.49331571663172 -1 4.52692512018667 37 150 321 231 82 7 86 71 159 362 23 29 M17142 GO_APICAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PART_OF_CELL.html The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. 410/594 Gene Ontology CC GO:0045177 8.32056718660192e-35 9.66849907083143e-33 235 112.272727272727 87 7.56415198781999e-36 3 2.69301018793733 -2.71145543035878 -1 47.6255463641627 231 148 3 3 67 233 230 87 69 8 156 30 M17224 GO_AXON_INITIAL_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_INITIAL_SEGMENT.html Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. 17/26 Gene Ontology CC GO:0043194 1.40100899001176e-06 7.1326376758392e-06 500 257.545454545455 88 1.27364534746025e-07 3 3.00773114112626 2.89078055869285 1 8.48789130358194 499 81 80 88 66 559 473 371 3 72 541 31 M16974 GO_FILOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM.html Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. 140/172 Gene Ontology CC GO:0030175 1.41308934120323e-06 7.1326376758392e-06 85 137.272727272727 89 1.28462749895471e-07 45 2.39034843938781 2.77949490161156 1 6.72979130644348 245 201 45 84 89 149 324 81 84 86 122 32 M17597 GO_INHIBITORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INHIBITORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. 9/20 Gene Ontology CC GO:0060077 2.93744434615312e-07 3.10300939111811e-06 90 181.363636363636 89 2.93744473443925e-08 1 2.69962878497369 2.33900654573455 1 8.15043786267081 88 243 556 295 1 89 35 37 430 187 34 33 M17132 GO_MITOTIC_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE.html A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. 71/75 Gene Ontology CC GO:0072686 3.85526162959806e-06 1.1034024664022e-05 30 110.909090909091 90 3.50478944140265e-07 26 1.73895770771263 1.92872539925686 1 4.69253499577378 36 27 190 182 182 26 62 57 220 148 90 34 M17584 GO_SPINDLE_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_MICROTUBULE.html Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. 69/78 Gene Ontology CC GO:0005876 7.25472012827078e-06 1.6529381939315e-05 75 106.909090909091 91 6.59522186504249e-07 28 1.88890963010785 1.99456391097755 1 4.92038434977651 72 28 156 132 233 66 65 42 129 162 91 35 M17625 GO_T_TUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_TUBULE.html Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. 57/87 Gene Ontology CC GO:0030315 1.41840177144145e-06 7.1326376758392e-06 325 174.181818181818 92 1.28945698720521e-07 34 2.59911574811118 3.27119315933611 1 7.32429096416899 322 36 46 92 221 314 549 34 177 56 69 36 M17784 GO_CILIARY_BASAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASAL_BODY.html A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. 84/106 Gene Ontology CC GO:0036064 1.54330167491341e-06 7.17131502932038e-06 10 149.727272727273 93 1.40300250685616e-07 8 1.50152129025631 1.45108470452467 1 4.19675685941546 17 259 315 313 93 8 10 8 345 240 39 37 M17056 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. 17/18 Gene Ontology CC GO:0012510 9.47085287982035e-07 6.94007103560441e-06 175 108.909090909091 95 8.60986996087423e-08 15 1.68590558701217 -1.64277933433635 -1 4.73486055187076 174 95 193 44 15 179 63 18 36 250 131 38 M17189 GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMPA_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. 19/32 Gene Ontology CC GO:0032281 1.46026671944896e-05 2.70195848407595e-05 95 132.090909090909 95 1.32752401106396e-06 20 2.65623640068724 2.81911377531703 1 6.63684672552589 77 91 109 171 297 70 20 83 299 95 141 39 M17606 GO_APICAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the apical end of the cell. 326/492 Gene Ontology CC GO:0016324 4.08503290776314e-32 3.95567353235064e-30 160 84.8181818181818 96 3.71366627978471e-33 4 2.82639654503878 -2.75584240275982 -1 45.9037837721779 127 158 4 4 96 160 159 52 64 9 100 40 M17774 GO_COATED_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_MEMBRANE.html A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. 95/109 Gene Ontology CC GO:0048475 3.23112103708096e-06 9.82869802379076e-06 60 145.181818181818 96 2.9373870751003e-07 15 1.43953412865672 -1.24163597822483 -1 3.91128198658225 60 15 325 178 170 56 59 141 96 426 71 41 M17824 GO_SYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_MEMBRANE.html A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 218/356 Gene Ontology CC GO:0097060 8.99538229642318e-11 1.63322409819433e-09 80 122.636363636364 96 8.17762026981e-12 22 2.33292691704571 2.6720191633987 1 11.2650306777401 152 177 22 77 146 96 329 67 171 36 76 42 M17009 GO_MUSCLE_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_MYOSIN_COMPLEX.html A filament of myosin found in a muscle cell of any type. 11/27 Gene Ontology CC GO:0005859 2.44902034238584e-06 8.72933017746117e-06 15 85.8181818181818 97 2.22638460783423e-07 14 3.12293462935139 3.2183319629722 1 8.66436231403224 89 109 137 38 130 115 97 14 18 183 14 43 M17729 GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. 23/29 Gene Ontology CC GO:0031233 5.95153506278942e-05 8.91196358629035e-05 480 247.363636363636 98 5.41063279307785e-06 24 3.2223079717277 -3.90015100412619 -1 7.1436041569323 478 76 82 24 373 560 550 74 65 98 341 44 M17801 GO_PLASMA_MEMBRANE_RAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RAFT.html A membrane raft that is part of the plasma membrane. 114/155 Gene Ontology CC GO:0044853 2.81349444212642e-06 9.1513864675994e-06 100 98.7272727272727 98 2.55772549109226e-07 6 2.34376712253173 2.69458678011301 1 6.45678266248587 98 6 67 100 149 64 153 20 272 131 26 45 M17215 GO_NEURONAL_POSTSYNAPTIC_DENSITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_POSTSYNAPTIC_DENSITY.html A postsynaptic density that is part of a neuron. 73/96 Gene Ontology CC GO:0097481 1.06438394072755e-06 6.94007103560441e-06 100 131.181818181818 99 9.67622232444029e-08 24 2.20001639974235 2.43722552515282 1 6.20225775351873 162 24 88 99 27 98 286 286 168 130 75 46 M17733 GO_GOLGI_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LUMEN.html The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. 58/156 Gene Ontology CC GO:0005796 4.98070940529593e-11 9.33481343379656e-10 500 255.545454545455 99 4.52791764128062e-12 9 3.63046494743276 2.97298243625437 1 18.0613597869326 497 34 21 9 99 566 494 501 95 52 443 47 M17637 GO_LYTIC_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE.html A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. 553/770 Gene Ontology CC GO:0000323 1.41920818184595e-06 7.1326376758392e-06 70 162.272727272727 100 1.4192090882151e-07 5 1.80919277009694 -1.68760456805901 -1 5.07485381363672 66 250 562 205 77 5 100 94 251 156 19 48 M17803 GO_FILAMENTOUS_ACTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILAMENTOUS_ACTIN.html A two-stranded helical polymer of the protein actin. 34/46 Gene Ontology CC GO:0031941 1.35965937194198e-06 7.1326376758392e-06 285 169.363636363636 101 1.23605473840808e-07 17 2.34364773243901 2.98518080012301 1 6.59680327078607 285 56 121 101 63 438 543 17 41 166 32 49 M17488 GO_VACUOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_PART.html Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. 743/967 Gene Ontology CC GO:0044437 1.19886475652664e-06 6.94007103560441e-06 55 162 102 1.19886540330164e-07 1 1.65387593921071 -1.48744452949661 -1 4.64344015301932 52 138 544 226 59 1 96 102 211 340 13 50 M17445 GO_LATE_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATE_ENDOSOME.html A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. 238/279 Gene Ontology CC GO:0005770 1.8760218852799e-06 7.76905242654465e-06 25 146.272727272727 103 1.70547589548681e-07 6 1.70326425837137 -1.61426650426971 -1 4.73822462130282 23 289 272 252 103 6 61 98 136 349 20 51 M17262 GO_CELL_CORTEX_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_REGION.html The complete extent of cell cortex that underlies some some region of the plasma membrane 16/25 Gene Ontology CC GO:0099738 4.28098750124105e-07 4.07746514462467e-06 5 122 105 3.89180757661827e-08 1 2.61919232805167 -3.33249762137517 -1 7.73341098923454 279 87 105 28 2 287 281 21 1 136 115 52 M17419 GO_CATION_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_CHANNEL_COMPLEX.html An ion channel complex through which cations pass. 118/225 Gene Ontology CC GO:0034703 1.99072153827963e-14 6.08741691442351e-13 120 104.363636363636 105 1.80974685298149e-15 1 2.81050342704288 2.96520570082632 1 18.9185107815106 116 1 12 72 119 68 186 155 291 23 105 53 M17016 GO_FILOPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a filopodium. 19/22 Gene Ontology CC GO:0031527 3.74322031437373e-06 1.08199552370703e-05 55 121.454545454545 106 3.40293334849334e-07 11 2.49189991319557 2.82889376014308 1 6.76945568667667 53 230 125 106 325 101 114 16 48 207 11 54 M17540 GO_CHROMOCENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOCENTER.html A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure. 13/17 Gene Ontology CC GO:0010369 1.79981075284027e-05 3.16875771939454e-05 30 147.636363636364 106 1.63620497925912e-06 16 1.83685613502692 1.9649651962455 1 4.49542040843527 26 106 177 268 389 37 16 44 247 229 85 55 M17785 GO_TRANS_GOLGI_NETWORK_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_MEMBRANE.html The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. 82/97 Gene Ontology CC GO:0032588 1.44343834711145e-06 7.1326376758392e-06 150 140.090909090909 108 1.31221754014932e-07 22 1.37279671480495 -1.24974889685794 -1 3.83214341472256 150 22 320 46 68 65 78 249 120 315 108 56 M17447 GO_LAMELLIPODIUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_MEMBRANE.html The portion of the plasma membrane surrounding a lamellipodium. 32/37 Gene Ontology CC GO:0031258 1.00879313617555e-06 6.94007103560441e-06 115 101 109 9.17085089772914e-08 7 2.35244696705102 2.66789570090421 1 6.63733163715583 114 58 115 109 23 111 292 7 71 194 17 57 M17725 GO_ACTIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT.html A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. 93/112 Gene Ontology CC GO:0005884 9.49689082916437e-07 6.94007103560441e-06 540 229.818181818182 109 8.63354084432258e-08 9 2.23026452134557 2.55673904758194 1 6.28859324364383 540 9 94 80 16 526 433 282 45 109 394 58 M17602 GO_NONMOTILE_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM.html A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 149/208 Gene Ontology CC GO:0031513 1.13887983087162e-06 6.94007103560441e-06 115 160.818181818182 111 1.03534583676272e-07 30 2.1217203628209 1.91429360140875 1 5.9787818361994 106 198 111 122 36 30 189 569 111 103 194 59 M17358 GO_SPECIFIC_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFIC_GRANULE.html Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. 22/29 Gene Ontology CC GO:0042581 0.000101807314429464 0.000140498930364652 115 153.636363636364 113 9.25563872502627e-06 11 2.16547161336961 -2.30908764982778 -1 4.53851380209743 44 226 186 111 404 113 81 119 11 299 96 60 M17574 GO_CILIARY_BASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_BASE.html Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. 22/25 Gene Ontology CC GO:0097546 4.58463500719672e-06 1.23124345784652e-05 195 134.363636363636 115 4.16785869205466e-07 49 1.81039145039297 1.65400029592561 1 4.84077541429228 76 228 194 170 193 75 57 53 115 268 49 61 M17379 GO_VOLTAGE_GATED_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_SODIUM_CHANNEL_COMPLEX.html A sodium channel in a cell membrane whose opening is governed by the membrane potential. 5/14 Gene Ontology CC GO:0001518 6.87300716846175e-06 1.59092317325748e-05 35 170.636363636364 116 6.87302842575667e-07 21 4.52893430057324 4.52893430057324 1 11.9467407523975 34 116 533 208 449 60 21 26 200 129 101 62 M17685 GO_PRIMARY_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_CILIUM.html A cilium found on many different cell types that is typically present in a single copy per cell. A primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors. 233/307 Gene Ontology CC GO:0072372 7.39797660314295e-07 6.41526030809859e-06 65 126.545454545455 116 6.72543553715821e-08 7 1.95387246887274 1.80761056875468 1 5.53662116743173 64 179 132 225 7 11 116 317 164 74 103 63 M17257 GO_DENDRITIC_SHAFT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SHAFT.html Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. 47/67 Gene Ontology CC GO:0043198 2.12394464083128e-05 3.62944657742051e-05 110 144.454545454545 117 1.93087740572187e-06 44 2.29098096931714 2.56111820587373 1 5.55116177924942 139 44 96 107 318 109 218 117 187 174 80 64 M17835 GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_TRANS_GOLGI_NETWORK_VESICLE.html A clathrin coat found on a vesicle of the trans-Golgi network. 15/16 Gene Ontology CC GO:0030130 2.99293058538102e-06 9.2988912839913e-06 145 124.636363636364 117 2.72084968821851e-07 33 1.45856605127669 -1.69580308237606 -1 3.98343295706152 145 103 233 52 160 154 43 33 47 284 117 65 M17364 GO_LATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_PLASMA_MEMBRANE.html The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. 69/93 Gene Ontology CC GO:0016328 2.09719040937289e-08 2.64884266922967e-07 15 198.272727272727 118 1.90653675396794e-09 14 2.73756232178608 -2.82808619904063 -1 9.88482278578233 467 20 34 14 215 465 454 340 14 40 118 66 M17544 GO_SARCOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASM.html The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. 72/102 Gene Ontology CC GO:0016528 1.59234564929231e-06 7.22775642374086e-06 90 167 119 1.44758800165715e-07 79 2.26460814963591 2.45151579526033 1 6.36451599475528 87 215 119 290 79 95 209 278 292 89 84 67 M17620 GO_INTERMEDIATE_FILAMENT_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_CYTOSKELETON.html Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. 153/303 Gene Ontology CC GO:0045111 3.93580134625374e-07 3.81116763695571e-06 120 117.454545454545 119 3.57800186397184e-08 9 2.6425163630814 2.92827791236868 1 7.84585046854654 119 193 41 149 9 71 134 387 119 54 16 68 M17023 GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 18/21 Gene Ontology CC GO:0031362 1.92500259075004e-05 3.32865031317194e-05 95 231 121 1.7500176679561e-06 78 3.05898655420273 2.4597345602794 1 7.50152374140427 481 90 95 91 314 319 381 121 78 104 467 69 M17230 GO_CILIARY_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TIP.html Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. 55/63 Gene Ontology CC GO:0097542 2.17866205005795e-06 8.27321994172334e-06 30 189.636363636364 121 1.98060382508364e-07 12 1.37648101617941 1.3371929638655 1 3.79356952153335 24 355 324 419 121 12 29 30 449 257 66 70 M17357 GO_GLIAL_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_PROJECTION.html A prolongation or process extending from a glial cell. 22/32 Gene Ontology CC GO:0097386 1.2944674929221e-05 2.46585447012374e-05 125 137.636363636364 123 1.17679555414362e-06 15 2.4666858021053 2.76888252755943 1 6.21193182528392 123 270 160 173 286 106 44 51 40 246 15 71 M17128 GO_SITE_OF_POLARIZED_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_POLARIZED_GROWTH.html Any part of a cell where non-isotropic growth takes place. 216/272 Gene Ontology CC GO:0030427 1.05132477215603e-07 1.24657080127073e-06 115 147.545454545455 124 9.55749838542007e-09 36 2.31267999646145 2.55924611035699 1 7.47795111665744 273 180 36 78 112 124 341 143 114 60 162 72 M17304 GO_BRUSH_BORDER http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER.html The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. 117/186 Gene Ontology CC GO:0005903 9.82875898617937e-07 6.94007103560441e-06 125 202.272727272727 124 8.93523943390536e-08 18 2.41411928240821 -2.4418194239066 -1 6.81335941313998 407 210 65 124 18 455 294 122 86 101 343 73 M17605 GO_MICROTUBULE_ASSOCIATED_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ASSOCIATED_COMPLEX.html Any multimeric complex connected to a microtubule. 143/174 Gene Ontology CC GO:0005875 2.33980025142334e-06 8.47322892374399e-06 125 164.181818181818 125 2.1270933999193e-07 64 1.85044842006844 2.14173286865777 1 5.11575399653733 122 291 206 270 125 79 125 76 207 241 64 74 M17744 GO_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_CHANNEL_COMPLEX.html An ion channel complex through which calcium ions pass. 56/87 Gene Ontology CC GO:0034704 2.44681014553215e-06 8.72933017746117e-06 60 135.454545454545 125 2.22437533349584e-07 54 2.33644192461598 2.41129032487218 1 6.46287051102688 59 218 100 165 129 54 70 126 387 125 57 75 M17012 GO_IMMUNOLOGICAL_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE.html An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 36/68 Gene Ontology CC GO:0001772 2.34800319573629e-06 8.47322892374399e-06 535 246.090909090909 126 2.13455063791201e-07 17 2.21826955556206 2.57222689278523 1 6.14796335424417 532 47 93 22 126 531 428 263 17 73 575 76 M17116 GO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE.html A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. 1232/1632 Gene Ontology CC GO:0005773 1.56262222550929e-06 7.17131502932038e-06 75 151.272727272727 126 1.56262332431507e-07 3 1.77908385165535 -1.63546520184625 -1 4.98680175997688 75 126 516 222 91 3 133 97 219 157 25 77 M17816 GO_CLATHRIN_ADAPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_ADAPTOR_COMPLEX.html A membrane coat adaptor complex that links clathrin to a membrane. 31/34 Gene Ontology CC GO:0030131 2.11927857013942e-06 8.10066348191448e-06 130 132.636363636364 126 1.92661873787373e-07 10 1.39318674376406 -1.54418096455218 -1 3.84760264664404 126 64 285 56 168 136 149 10 66 355 44 78 M17231 GO_PRONUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRONUCLEUS.html The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. 19/23 Gene Ontology CC GO:0045120 8.09752852469996e-06 1.7753449331512e-05 130 160.909090909091 128 7.36141666307686e-07 35 1.77455696053527 1.95811882906836 1 4.58737722407169 128 235 225 215 243 126 104 35 89 329 41 79 M17709 GO_MYOSIN_II_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_II_COMPLEX.html A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. 15/31 Gene Ontology CC GO:0016460 2.05069148260895e-06 8.00162624298156e-06 135 108.909090909091 128 1.86426672193419e-07 9 2.75865917433961 2.67153467426273 1 7.70240967571757 134 100 140 36 128 147 201 9 16 178 109 80 M17786 GO_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME.html A vacuole to which materials ingested by endocytosis are delivered. 860/1101 Gene Ontology CC GO:0005768 1.93499687256842e-06 7.91713509128348e-06 70 166.818181818182 128 1.93499855746629e-07 10 1.75479242698644 -1.62364705267101 -1 4.87593990069427 70 134 577 224 120 10 123 128 186 220 43 81 M17060 GO_EXCITATORY_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_SYNAPSE.html A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. 236/315 Gene Ontology CC GO:0060076 5.12061386885370e-09 7.8291490994842e-08 135 127.272727272727 131 4.65510352797471e-10 27 2.26384610658241 2.65418222364426 1 8.82401574412733 131 173 27 81 133 77 339 151 140 53 95 82 M17599 GO_SUPRAMOLECULAR_FIBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPRAMOLECULAR_FIBER.html A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. 562/821 Gene Ontology CC GO:0099512 4.09582811888733e-08 4.9576586189032e-07 135 158 131 4.09582819437845e-09 29 2.07412436846602 2.36022294315446 1 7.15818202647446 188 143 557 59 72 67 240 131 132 29 120 83 M17185 GO_CLATHRIN_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT.html A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. 53/66 Gene Ontology CC GO:0030118 5.15161289448314e-06 1.3185405690285e-05 45 150.363636363636 133 4.6832954161427e-07 41 1.73733264962622 -1.45710663059188 -1 4.6137154201564 138 41 231 113 205 133 82 203 44 377 87 84 M17494 GO_DENDRITE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MEMBRANE.html The portion of the plasma membrane surrounding a dendrite. 22/37 Gene Ontology CC GO:0032590 2.28463004832804e-05 3.84744944370605e-05 40 150.545454545455 133 2.07695797620873e-06 36 3.26927985930988 3.5741956888359 1 7.90873925107659 153 227 66 37 323 128 145 60 348 133 36 85 M17296 GO_COSTAMERE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COSTAMERE.html Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. 28/29 Gene Ontology CC GO:0043034 1.46095707338005e-06 7.1326376758392e-06 100 137 135 1.32814367596432e-07 23 2.25858060454748 2.32076301725163 1 6.35456046598841 99 225 138 207 69 135 265 23 61 203 82 86 M17348 GO_CYTOSKELETAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETAL_PART.html Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. 1329/1737 Gene Ontology CC GO:0044430 1.54464721630587e-06 7.17131502932038e-06 135 181.181818181818 135 1.54464828997768e-07 41 1.81027030296209 1.96547682605231 1 5.07556984417853 135 121 529 355 88 41 170 162 184 75 133 87 M17408 GO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE.html The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. 747/1081 Gene Ontology CC GO:0045202 3.22062583583338e-13 8.13558091573564e-12 165 174.545454545455 135 3.22062583583385e-14 16 2.22923059538822 2.55534299485591 1 13.6010268841818 165 135 535 60 92 61 358 194 198 16 106 88 M17682 GO_LYTIC_VACUOLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_MEMBRANE.html The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell. 320/391 Gene Ontology CC GO:0098852 2.52597955211633e-06 8.84092843240716e-06 25 152.454545454545 136 2.29634768398301e-07 4 1.63919849097567 -1.52509400304428 -1 4.5061949697254 25 287 313 188 136 4 69 92 217 322 24 89 M17277 GO_PARANODE_REGION_OF_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARANODE_REGION_OF_AXON.html An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. 18/35 Gene Ontology CC GO:0033270 2.31212787166277e-06 8.47322892374399e-06 515 250.545454545455 137 2.10193663785176e-07 29 2.7233126522874 2.8342433846363 1 7.56525605490842 512 84 107 35 124 475 495 214 29 137 544 90 M17791 GO_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a transport vesicle. 154/216 Gene Ontology CC GO:0030658 1.20457385258288e-06 6.94007103560441e-06 200 146.818181818182 137 1.09506773829819e-07 34 1.88541434645667 -1.76244559593692 -1 5.30430703707192 100 194 124 34 44 200 196 137 279 91 216 91 M17654 GO_WNT_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALOSOME.html A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. 18/21 Gene Ontology CC GO:1990909 6.60813196734702e-06 1.54811478751154e-05 170 141.545454545455 140 6.00741074204759e-07 18 1.96539941877157 2.3315559892216 1 5.15369572593809 109 94 170 140 227 127 167 135 178 192 18 92 M17796 GO_PHOTORECEPTOR_OUTER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT.html The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes. 72/111 Gene Ontology CC GO:0001750 9.40049994013621e-07 6.94007103560441e-06 25 234.272727272727 142 8.5459126881177e-08 14 2.42588472475785 2.24564456406364 1 6.84694084491016 550 23 86 21 14 498 552 209 92 142 390 93 M17323 GO_MICROVILLUS_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_MEMBRANE.html The portion of the plasma membrane surrounding a microvillus. 25/30 Gene Ontology CC GO:0031528 7.61490831630886e-06 1.68222879535188e-05 400 222.363636363636 143 6.9226678855327e-07 74 2.53280224480576 -2.19115933253477 -1 6.61324741881455 399 74 91 97 240 329 143 347 87 115 524 94 M17414 GO_POSTSYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE.html A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. 158/268 Gene Ontology CC GO:0045211 3.0122374628599e-09 5.00031418834743e-08 190 135.636363636364 143 2.73839769725841e-10 25 2.46346559223424 2.83767792458312 1 9.87429654072145 143 189 25 157 187 88 323 133 148 49 50 95 M17499 GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION.html The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 113/125 Gene Ontology CC GO:0000779 4.52511335046402e-06 1.22647049924368e-05 5 155.818181818182 143 4.11374787096307e-07 1 1.79218936832489 1.88621720236435 1 4.79300242578262 1 328 204 303 342 21 8 82 188 143 94 96 M17618 GO_LATERAL_ELEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_ELEMENT.html A proteinaceous core found between sister chromatids during meiotic prophase. 8/115 Gene Ontology CC GO:0000800 1.15591966542751e-05 2.26130245197045e-05 125 231.363636363636 143 1.15592567814776e-06 14 1.63574612230229 1.65574171897374 1 4.12740802098856 115 323 558 315 283 130 14 123 420 121 143 97 M17771 GO_RECYCLING_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME.html An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. 147/172 Gene Ontology CC GO:0055037 2.61888087930604e-06 8.90667278448563e-06 110 157.545454545455 143 2.38080363348007e-07 77 1.74039435738057 -1.63129309139759 -1 4.78604759248963 107 205 213 210 143 90 77 120 240 217 111 98 M17092 GO_GLYCOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_COMPLEX.html A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. 17/23 Gene Ontology CC GO:0090665 1.70805812695973e-05 3.0496767763799e-05 160 138.181818181818 144 1.55279217117941e-06 7 2.44211940853039 2.08318965018191 1 6.02459911767334 158 233 142 160 305 144 93 77 26 175 7 99 M17176 GO_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COAT.html A membrane coat found on a coated vesicle. 51/55 Gene Ontology CC GO:0030120 2.89279688715579e-06 9.28571818473764e-06 115 163 144 2.62981880993056e-07 45 1.41733524043788 -1.64174182966139 -1 3.86913176967284 112 45 329 115 153 198 144 89 46 383 179 100 M17782 GO_PHOTORECEPTOR_DISC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_DISC_MEMBRANE.html Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment. 19/33 Gene Ontology CC GO:0097381 3.21111794404327e-07 3.33153486694489e-06 440 202.181818181818 144 2.9191985570344e-08 3 2.62424823808671 -2.67294416738436 -1 7.8758932947163 436 85 144 41 86 508 481 3 13 209 218 101 M17255 GO_MICROVILLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS.html Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. 91/118 Gene Ontology CC GO:0005902 1.95839991947493e-07 2.23103990826458e-06 355 154.454545454545 145 1.78036372164377e-08 12 2.61324278298601 -2.86141743298388 -1 8.09432359467777 351 12 37 65 161 372 191 145 73 59 233 102 M17831 GO_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE.html A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. 517/725 Gene Ontology CC GO:0030425 2.79669881791291e-06 9.1513864675994e-06 240 199.090909090909 145 2.79670233760507e-07 58 2.25972131163504 2.58101266977516 1 6.22248145812643 240 145 579 79 162 139 424 91 154 58 119 103 M17057 GO_ENDOSOME_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_LUMEN.html The volume enclosed by the membrane of an endosome. 24/42 Gene Ontology CC GO:0031904 0.000177891850870672 0.000233307371006457 60 203.363636363636 147 1.61732942565679e-05 31 2.26105812710796 -2.52470793528525 -1 4.46670737322654 56 446 185 308 425 92 31 99 147 381 67 104 M17547 GO_CELL_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION.html A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. 434/593 Gene Ontology CC GO:0005911 2.60283255310726e-26 1.51224571335532e-24 355 215.181818181818 147 2.36621141191568e-27 5 2.51165748036441 2.66361325004963 1 33.0257054482895 352 147 6 5 54 284 453 554 67 11 434 105 M17740 GO_CELL_LEADING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_LEADING_EDGE.html The area of a motile cell closest to the direction of movement. 448/544 Gene Ontology CC GO:0031252 1.46188459469872e-06 7.1326376758392e-06 70 260.636363636364 149 1.32898687828336e-07 63 2.01496147055798 2.2022257560378 1 5.66081443526262 444 149 63 68 70 388 579 425 145 77 459 106 M17177 GO_POSTSYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPSE.html The part of a synapse that is part of the post-synaptic cell. 372/552 Gene Ontology CC GO:0098794 2.29379562384536e-12 5.12575099020829e-11 140 157.636363636364 150 2.0852687489525e-13 17 2.31138657760359 2.68808543540397 1 13.0828267093786 209 156 17 154 137 150 437 138 163 38 135 107 M17827 GO_ANCHORED_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 98/186 Gene Ontology CC GO:0031225 1.46545878379723e-27 9.46035059317992e-26 5 209.727272727273 151 1.33223525799749e-28 3 3.50264680554412 3.34224347008182 1 48.4194151961565 394 3 5 6 151 330 577 172 81 12 576 108 M17091 GO_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. 467/581 Gene Ontology CC GO:0015629 1.31717564383066e-06 7.1326376758392e-06 120 258 152 1.1974331204052e-07 58 1.94034751093811 2.10486897535084 1 5.448338766889 440 152 118 118 58 445 563 350 93 112 389 109 M17250 GO_NODE_OF_RANVIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NODE_OF_RANVIER.html An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. 19/32 Gene Ontology CC GO:0033268 1.02325524544607e-05 2.06427533890335e-05 80 166.727272727273 152 9.30236368001032e-07 60 2.74699920727229 3.01480677715734 1 7.04395402303798 241 78 76 108 268 207 282 152 60 65 297 110 M17468 GO_FILOPODIUM_TIP http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_TIP.html The end of a filopodium distal to the body of the cell. 28/35 Gene Ontology CC GO:0032433 9.90133782055573e-07 6.94007103560441e-06 385 235.454545454545 154 9.00122025160241e-08 19 2.58028664428354 2.43171161991706 1 7.28764144686383 383 65 114 102 19 355 537 523 22 154 316 111 M17355 GO_CORTICAL_ACTIN_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_ACTIN_CYTOSKELETON.html The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. 82/106 Gene Ontology CC GO:0030864 1.8384598386562e-06 7.7401823641975e-06 390 209 155 1.67132852271991e-07 18 2.50922282601868 2.63625569556362 1 7.01901846987519 390 18 78 87 101 285 387 373 42 155 383 112 M17629 GO_NEURON_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a neuron projection. 46/74 Gene Ontology CC GO:0032589 5.63273792281029e-06 1.39260456729905e-05 185 166.181818181818 155 5.12068394960036e-07 24 2.95045841122745 3.06064214205081 1 7.85043799650746 182 264 56 134 246 155 244 24 297 100 126 113 M17818 GO_GAP_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAP_JUNCTION.html A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons. 19/35 Gene Ontology CC GO:0005921 7.21173931112717e-06 1.65003149698352e-05 140 144.636363636364 155 6.55614813797618e-07 54 3.92700102138057 4.35916985851864 1 10.3142450004349 136 89 54 155 231 180 172 157 101 117 199 114 M17344 GO_PHAGOCYTIC_CUP http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_CUP.html An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. 34/43 Gene Ontology CC GO:0001891 2.56281562747495e-05 4.21811863898852e-05 40 142.545454545455 156 2.32985952965103e-06 37 1.93410446819298 -2.13072492465633 -1 4.60456194339785 200 59 182 40 331 156 110 166 68 219 37 115 M17172 GO_LIPID_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE.html An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. 70/94 Gene Ontology CC GO:0005811 2.10549330270889e-06 8.10066348191448e-06 160 171.363636363636 157 1.91408665250725e-07 33 1.81749325595741 -1.89236641339568 -1 5.04291042566587 157 33 210 415 118 114 140 235 222 180 61 116 M17158 GO_APICAL_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_COMPLEX.html A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. 136/174 Gene Ontology CC GO:0043296 5.49235734040718e-06 1.36955348273673e-05 70 177.090909090909 158 4.99306459297123e-07 12 2.3042376419463 -2.58523713325172 -1 6.12335455845718 281 207 68 12 211 416 325 142 59 69 158 117 M17212 GO_CORTICAL_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON.html The portion of the cytoskeleton that lies just beneath the plasma membrane. 102/134 Gene Ontology CC GO:0030863 2.51787959596647e-06 8.84092843240716e-06 345 216 160 2.28898407060085e-07 7 2.35120913554798 2.46462656212951 1 6.49702872576936 344 7 83 94 135 268 418 392 160 147 328 118 M17085 GO_CYTOPLASMIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_REGION.html Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm\ 351/475 Gene Ontology CC GO:0099568 2.62447867397614e-06 8.90667278448563e-06 475 291.090909090909 161 2.38589254985426e-07 87 2.06337309150399 2.24135624654225 1 5.68854472195552 471 161 87 156 144 376 524 563 138 146 436 119 M17141 GO_CELL_PROJECTION_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_MEMBRANE.html The portion of the plasma membrane surrounding a cell surface projection. 333/464 Gene Ontology CC GO:0031253 2.49837096693774e-11 4.83851177263609e-10 385 228.636363636364 162 2.27124633360556e-12 8 2.28240257185042 2.44871986380149 1 11.6865941675661 381 162 20 69 8 302 498 542 131 39 363 120 M17182 GO_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON.html The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. 460/668 Gene Ontology CC GO:0030424 2.16811651071276e-09 3.81719906886096e-08 165 163.727272727273 162 1.97101501168133e-10 23 2.19806809197602 2.56469880816775 1 8.9447962083217 261 151 23 75 127 162 443 174 191 31 163 121 M17764 GO_BRUSH_BORDER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRUSH_BORDER_MEMBRANE.html The portion of the plasma membrane surrounding the brush border. 60/96 Gene Ontology CC GO:0031526 8.60810086220267e-07 6.94007103560441e-06 330 186.181818181818 162 7.82554930032644e-08 10 2.68476383730408 -2.57202348927854 -1 7.58584474638251 328 217 75 162 10 408 307 86 100 118 237 122 M17531 GO_LAMELLIPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM.html A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. 234/281 Gene Ontology CC GO:0030027 2.09628760816545e-06 8.10066348191448e-06 75 185.454545454545 163 1.90571782330231e-07 71 2.00064943272473 2.25475785595972 1 5.55887705963098 272 171 71 73 117 163 438 308 104 127 196 123 M17573 GO_PODOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PODOSOME.html An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. 30/34 Gene Ontology CC GO:0002102 8.50486083404806e-05 0.000121110885896616 155 195.454545454545 164 7.73199057877437e-06 50 2.09168376683752 1.84538865364015 1 4.45587237169028 151 69 164 98 394 187 151 266 50 294 326 124 M17721 GO_SPINDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE.html The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. 342/399 Gene Ontology CC GO:0005819 7.76498031245372e-06 1.7088839248241e-05 270 160.727272727273 165 7.05909792670056e-07 28 1.62377374836035 1.77759942680488 1 4.20592398190608 47 165 270 266 242 28 58 80 236 260 116 125 M17513 GO_TRANSPORTER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORTER_COMPLEX.html A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. 208/394 Gene Ontology CC GO:1990351 5.96573994328461e-19 2.31072993803224e-17 110 154.727272727273 166 5.42339994844053e-20 10 2.73880168118103 2.74189668146949 1 25.132833109048 166 181 10 63 110 110 252 360 226 18 206 126 M17612 GO_CELL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX.html The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 298/408 Gene Ontology CC GO:0005938 1.6773832063356e-06 7.38302759758319e-06 435 268.909090909091 166 1.52489498659328e-07 58 2.12932266686102 2.245963122318 1 5.9688233128608 431 166 58 153 85 342 510 572 121 94 426 127 M17010 GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOLTAGE_GATED_CALCIUM_CHANNEL_COMPLEX.html A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. 30/54 Gene Ontology CC GO:0005891 1.62093104139156e-06 7.24775657836278e-06 250 208.363636363636 167 1.47357475970314e-07 77 3.36429691816666 3.86172326386296 1 9.4903282559029 250 302 77 167 81 255 346 163 411 128 112 128 M17070 GO_SARCOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the sarcoplasmic reticulum. 31/45 Gene Ontology CC GO:0033017 3.19189923728788e-06 9.81213469240347e-06 180 161.909090909091 167 2.90173078936974e-07 60 2.24200814580233 2.4332884691297 1 6.13554323064914 176 60 126 209 167 158 173 222 310 83 97 129 M17129 GO_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. 305/423 Gene Ontology CC GO:0030139 1.95684207195407e-06 7.94334698860095e-06 170 195.818181818182 167 1.77894892046885e-07 108 1.89543265463093 -1.79107803352095 -1 5.27140449374413 251 167 157 139 108 217 291 136 332 190 166 130 M17347 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_CATALYTIC_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. 14/16 Gene Ontology CC GO:0033178 6.95685536735375e-07 6.21835841297312e-06 130 156.636363636364 167 6.32441597023307e-08 2 1.50136963811712 -1.8654424496599 -1 4.24776461797259 129 237 250 135 6 227 177 47 2 346 167 131 M17113 GO_T_CELL_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_COMPLEX.html A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. 10/24 Gene Ontology CC GO:0042101 3.22330274718326e-06 9.82869802379076e-06 430 213.636363636364 169 2.93027951797731e-07 41 2.56112212875206 -2.80590994945743 -1 7.0187789758729 427 110 128 183 169 539 392 41 55 214 92 132 M17349 GO_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE.html Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. 403/498 Gene Ontology CC GO:0005874 2.74265724595405e-06 9.05388556760966e-06 155 173.545454545455 170 2.49332787738876e-07 85 1.78868543301157 1.99122946884063 1 4.91394104104194 217 154 154 223 148 102 235 248 173 85 170 133 M17455 GO_NUCLEAR_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE_PART.html Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. 13/16 Gene Ontology CC GO:0044453 9.54297182098305e-05 0.000132642742296439 170 195.545454545455 170 8.67580526635631e-06 33 1.20920384998586 -1.41637872792758 -1 2.51697699680914 170 107 266 311 447 151 37 75 261 293 33 134 M17659 GO_CILIARY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_MEMBRANE.html The portion of the plasma membrane surrounding a cilium. 66/102 Gene Ontology CC GO:0060170 1.49598472379104e-06 7.17131502932038e-06 35 202.363636363636 171 1.3599870373193e-07 31 2.17326693800745 2.02069698183642 1 6.1087914681361 373 31 131 31 75 247 331 208 91 171 537 135 M17515 GO_PHOTORECEPTOR_CONNECTING_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CONNECTING_CILIUM.html A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments. 49/62 Gene Ontology CC GO:0032391 3.40865732900317e-06 1.01042342252594e-05 65 189 174 3.09878419123015e-07 44 1.86958013390943 1.65338498138945 1 5.09035633972943 63 263 214 253 174 44 128 494 144 195 107 136 M17655 GO_ACTIN_BASED_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_BASED_CELL_PROJECTION.html A cell projection supported by an assembly of actin filaments, and which lacks microtubules. 227/302 Gene Ontology CC GO:0098858 2.67950803364414e-12 5.76590432424907e-11 65 246.090909090909 174 2.43591639422491e-13 18 2.42634844282458 2.56748751252536 1 13.6687513406203 416 174 18 62 64 370 571 506 82 35 409 137 M17719 GO_EXTRINSIC_COMPONENT_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_MEMBRANE.html The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 257/326 Gene Ontology CC GO:0019898 4.51391021644834e-06 1.22647049924368e-05 175 182.818181818182 174 4.10356316183072e-07 126 1.94563046872221 -1.89433312465023 -1 5.20996590454606 214 172 150 126 191 174 219 283 150 134 198 138 M17833 GO_ORGANELLE_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_SUBCOMPARTMENT.html A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. 349/420 Gene Ontology CC GO:0031984 1.79207746569201e-06 7.65586034975779e-06 175 196.909090909091 174 1.62916265953212e-07 98 1.50475124318734 -1.30179052531863 -1 4.18230949697558 180 163 331 230 98 104 174 171 263 281 171 139 M17035 GO_BASOLATERAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASOLATERAL_PLASMA_MEMBRANE.html The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 220/324 Gene Ontology CC GO:0016323 2.10103800308164e-20 9.39002369069566e-19 10 251.090909090909 175 1.91003454825604e-21 7 2.64110877549316 2.3995009125937 1 26.2663980529578 522 175 8 7 166 562 526 332 117 14 333 140 M17439 GO_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a coated vesicle. 158/202 Gene Ontology CC GO:0030662 3.98498610050805e-06 1.12940337775374e-05 150 190.363636363636 175 3.62272119887281e-07 114 1.67151434871955 -1.51114100451236 -1 4.49819471669432 147 200 261 114 184 118 155 175 319 298 123 141 M17049 GO_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEMBRANE.html The lipid bilayer surrounding any membrane-bounded vesicle in the cell. 527/700 Gene Ontology CC GO:0012506 2.672799103179e-06 8.92469125831608e-06 150 205.727272727273 176 2.67280231791921e-07 84 1.84366226787815 -1.73983137483798 -1 5.07371302978573 148 146 513 250 156 84 181 176 313 197 99 142 M17760 GO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM.html A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. 473/685 Gene Ontology CC GO:0005929 1.10436060691414e-06 6.94007103560441e-06 130 178.181818181818 176 1.00396469207616e-07 24 1.81669407162792 1.79751496519824 1 5.108162671921 130 251 184 357 31 24 176 299 231 126 151 143 M17472 GO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE.html A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 140/151 Gene Ontology CC GO:0000776 1.71153144268763e-05 3.0496767763799e-05 5 159.727272727273 177 1.55594978001266e-06 4 1.72422908404257 1.85985970909174 1 4.23092442401918 4 353 255 267 306 16 12 84 204 177 79 144 M17518 GO_CLATHRIN_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated vesicle. 80/104 Gene Ontology CC GO:0030665 2.96293464891117e-06 9.2988912839913e-06 240 195.454545454545 177 2.69358058124085e-07 26 1.93203218247841 -1.83504311753767 -1 5.3015330560138 237 26 174 48 157 177 169 355 330 223 254 145 M17272 GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NMDA_SELECTIVE_GLUTAMATE_RECEPTOR_COMPLEX.html An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. 8/14 Gene Ontology CC GO:0017146 4.0520814029915e-05 6.38010649088906e-05 95 206.363636363636 178 4.05215529202436e-06 34 2.63942362962393 2.48854468552782 1 6.04941153164495 92 114 527 213 359 63 34 178 384 82 224 146 M17383 GO_ESCRT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_COMPLEX.html An endosomal sorting complex required for transport. 28/28 Gene Ontology CC GO:0036452 3.54514675853337e-06 1.03504033502909e-05 380 199.636363636364 178 3.22286588300302e-07 17 0.982352090252212 -0.903435949194033 -1 2.63239475522586 32 303 380 378 178 27 17 50 419 385 27 147 M17686 GO_RUFFLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE.html Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. 232/276 Gene Ontology CC GO:0001726 1.85935622353976e-06 7.76905242654465e-06 520 290.818181818182 178 1.69032526818064e-07 89 2.00081946104905 -1.84268300530827 -1 5.5794516606001 519 178 127 89 102 545 432 484 99 145 479 148 M16984 GO_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX.html A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants). 350/559 Gene Ontology CC GO:0031012 9.31333483213116e-51 2.7055237687341e-48 5 180.545454545455 180 8.46666802921014e-52 1 3.00961935243012 3.2522788125598 1 79.1329148419195 21 157 1 146 355 246 410 180 265 5 200 149 M17285 GO_STEREOCILIUM_BUNDLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEREOCILIUM_BUNDLE.html A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. 48/77 Gene Ontology CC GO:0032421 2.93900045499616e-06 9.2988912839913e-06 495 280.181818181818 181 2.67182216476504e-07 25 2.57249035606614 2.26372001765115 1 7.08452855737756 491 42 101 25 155 486 576 439 70 181 516 150 M17462 GO_NEURON_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION.html A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 1021/1429 Gene Ontology CC GO:0043005 9.59279040435406e-09 1.35936859144627e-07 185 205.727272727273 181 9.59279044576378e-10 27 2.19394567466658 2.502453131299 1 8.25829931881254 287 131 541 61 83 190 452 127 183 27 181 151 M17632 GO_SARCOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOLEMMA.html The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. 145/199 Gene Ontology CC GO:0042383 1.70963075027552e-11 3.5474838068217e-10 185 157.818181818182 181 1.55420977298982e-12 19 2.59762479845789 2.95240968611892 1 13.5050082037671 221 195 19 71 181 132 383 187 185 25 137 152 M17412 GO_CLATHRIN_COAT_OF_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_COATED_PIT.html The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. 20/22 Gene Ontology CC GO:0030132 1.51700170946499e-05 2.77162890943133e-05 170 192.272727272727 182 1.37910197272191e-06 20 1.3763832303634 -1.64185834768452 -1 3.39343746818101 167 93 280 116 300 225 215 112 20 405 182 153 M17491 GO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE.html The external part of the cell wall and/or plasma membrane. 680/1190 Gene Ontology CC GO:0009986 2.01389280529359e-24 1.06370156352325e-22 320 246.272727272727 182 2.01389280529359e-25 7 2.45001719277922 2.54422951757335 1 29.7092823864708 318 139 547 147 104 175 456 281 182 7 353 154 M17197 GO_TRANS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. 208/247 Gene Ontology CC GO:0005802 1.19492805467183e-06 6.94007103560441e-06 125 195.636363636364 183 1.08629882154221e-07 43 1.46546313851886 -1.33952247348415 -1 4.10566423070081 125 183 348 217 43 78 139 280 244 335 160 155 M17263 GO_NEURON_SPINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_SPINE.html A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. 165/235 Gene Ontology CC GO:0044309 3.9715660324658e-06 1.12940337775374e-05 185 184.727272727273 183 3.61052109289313e-07 51 2.3302079420616 2.68846708266512 1 6.30119026898309 252 190 51 172 183 184 362 183 224 66 165 156 M17149 GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_AND_POLYADENYLATION_SPECIFICITY_FACTOR_COMPLEX.html A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. 14/15 Gene Ontology CC GO:0005847 0.00111234120546938 0.00131355739914169 170 266.090909090909 185 0.000101173092211917 138 1.70629329811129 -1.70629329811129 -1 2.64329682051939 185 456 342 281 508 170 138 169 139 389 150 157 M17732 GO_SPERM_FLAGELLUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_FLAGELLUM.html A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. 52/88 Gene Ontology CC GO:0036126 1.88543268871393e-06 7.76905242654465e-06 160 208.181818181818 185 1.71403118596337e-07 28 1.56418988459651 1.65557815278972 1 4.34504338084749 160 220 246 483 105 171 185 28 326 238 128 158 M17205 GO_SODIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_CHANNEL_COMPLEX.html An ion channel complex through which sodium ions pass. 8/17 Gene Ontology CC GO:0034706 2.89186924062164e-05 4.71959558652015e-05 340 237.454545454545 186 2.89190687439559e-06 85 4.51219676794871 4.52893430057324 1 10.7232842576151 243 112 520 85 337 186 130 416 125 120 338 159 M17639 GO_CONDENSED_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. 215/358 Gene Ontology CC GO:0000793 1.68357459248425e-05 3.02834934437569e-05 5 186.363636363636 188 1.53053406942277e-06 2 1.68814113893736 1.79528230970722 1 4.14360419999734 2 389 299 304 361 20 13 63 323 188 88 160 M17062 GO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CENTROMERIC_REGION.html The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. 202/318 Gene Ontology CC GO:0000775 1.71642737672329e-05 3.0496767763799e-05 310 175.818181818182 189 1.5604006984886e-06 5 1.66614897079811 1.79877625561682 1 4.08580918039825 5 352 303 307 307 22 22 85 259 189 83 161 M17619 GO_CYTOPLASMIC_VESICLE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_VESICLE_PART.html Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. 589/882 Gene Ontology CC GO:0044433 2.25792375114956e-06 8.47322892374399e-06 150 224.909090909091 189 2.25792604535169e-07 131 1.98210952357031 -1.85617378440918 -1 5.48523201170972 189 249 559 206 131 137 200 179 328 149 147 162 M17648 GO_LAMELLAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLAR_BODY.html A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. 17/26 Gene Ontology CC GO:0042599 3.36717648223745e-06 1.00324591598972e-05 215 191.727272727273 189 3.06107421439014e-07 48 2.34737359672874 -2.30117050472919 -1 6.41498844551004 211 274 162 189 173 194 76 124 407 251 48 163 M17581 GO_DESMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DESMOSOME.html A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. 30/36 Gene Ontology CC GO:0030057 2.98449389464874e-06 9.2988912839913e-06 530 278.727272727273 190 2.71317994853221e-07 66 2.61427309396809 2.94636822125315 1 7.20084908662699 526 66 113 125 159 425 419 363 190 153 527 164 M17190 GO_CLATHRIN_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_VESICLE.html A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. 170/208 Gene Ontology CC GO:0030136 5.04129769699191e-06 1.30501955810939e-05 205 184.363636363636 191 4.58300840832488e-07 42 1.99088409173413 -1.69430455935632 -1 5.30324133203318 201 191 158 42 201 134 171 323 230 184 193 165 M17213 GO_MYOSIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_FILAMENT.html A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. 12/29 Gene Ontology CC GO:0032982 7.05026752720625e-05 0.000102661790308442 195 201.090909090909 192 6.40953952267679e-06 47 3.86218017340519 4.61974097876247 1 8.44618286563289 192 239 110 133 407 286 364 66 124 244 47 166 M17777 GO_EARLY_ENDOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME.html A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. 351/455 Gene Ontology CC GO:0005769 5.25503353576961e-06 1.33911161591322e-05 195 201.181818181818 192 4.77731462568716e-07 80 1.72445293370487 -1.54153631080199 -1 4.57252500194319 191 164 248 192 206 80 250 285 175 333 89 167 M17397 GO_CELL_DIVISION_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION_SITE.html The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. 66/80 Gene Ontology CC GO:0032153 4.31763293556146e-06 1.2002606390245e-05 195 186.818181818182 193 3.92512855381843e-07 35 1.55564848339508 1.80932961803087 1 4.15829715254177 193 261 273 238 188 119 146 211 85 306 35 168 M17664 GO_CELL_PROJECTION_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_PART.html Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. 1003/1408 Gene Ontology CC GO:0044463 3.77938049829358e-13 8.78328027803428e-12 280 223.090909090909 193 3.77938049829422e-14 17 2.10592254608622 2.27789187058493 1 12.8056673865351 278 130 565 148 30 123 384 344 193 17 242 169 M17334 GO_LEADING_EDGE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEADING_EDGE_MEMBRANE.html The portion of the plasma membrane surrounding the leading edge of a motile cell. 184/233 Gene Ontology CC GO:0031256 1.11161172699261e-06 6.94007103560441e-06 375 237.818181818182 195 1.01055662606002e-07 32 2.16231765893116 2.4438578081207 1 6.09465638548248 371 185 72 95 32 331 545 365 195 111 314 170 M17350 GO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON.html Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. 1838/2385 Gene Ontology CC GO:0005856 1.72756462882871e-06 7.546729694357e-06 200 214.090909090909 196 1.72756597184598e-07 87 1.80454902183436 1.95738652915343 1 5.03715941335628 198 118 530 412 106 94 264 196 210 87 140 171 M17595 GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE.html A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. 40/42 Gene Ontology CC GO:0030140 1.1264523904564e-06 6.94007103560441e-06 200 160.181818181818 196 1.02404815202479e-07 35 1.59965938246611 -1.36200245600507 -1 4.4886929240561 196 265 221 45 35 214 101 181 58 243 203 172 M17341 GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS.html A cell part consisting of multiple, closely packed actin-based cell projections. 149/238 Gene Ontology CC GO:0098862 5.46902369290425e-07 4.99535120992875e-06 565 256.636363636364 197 4.97184095678199e-08 3 2.48590283869231 2.38973123942347 1 7.21465640247594 564 197 42 119 3 569 447 220 88 84 490 173 M17529 GO_SEMAPHORIN_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_RECEPTOR_COMPLEX.html A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. 9/11 Gene Ontology CC GO:0002116 4.92688046199946e-05 7.57279774714732e-05 180 236.272727272727 197 4.92698969908795e-06 59 2.28430794649292 2.94395968775441 1 5.13106011570131 178 281 552 249 423 197 187 59 126 237 110 174 M17343 GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEINACEOUS_EXTRACELLULAR_MATRIX.html A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. 284/408 Gene Ontology CC GO:0005578 4.60074171363267e-47 8.91010311873528e-45 10 190.454545454545 198 4.18249246693883e-48 2 3.09993155844476 3.28910996096399 1 75.4764882280754 10 253 2 198 381 232 368 173 285 6 187 175 M17656 GO_CELL_PROJECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION.html A prolongation or process extending from a cell, e.g. a flagellum or axon. 1802/2503 Gene Ontology CC GO:0042995 8.76767408319428e-16 2.83001035685326e-14 245 219.636363636364 199 8.76767408319429e-17 13 2.09575115268904 2.25859114196719 1 15.6329330268675 244 117 564 199 34 142 396 305 162 13 240 176 M16985 GO_PHAGOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE.html A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. 134/188 Gene Ontology CC GO:0045335 5.01410273414817e-06 1.30501955810939e-05 95 187.090909090909 200 4.55828560183157e-07 55 1.70688346518975 -1.6857123602641 -1 4.53572952668938 94 256 238 195 200 105 223 61 303 328 55 177 M17362 GO_ENDOPLASMIC_RETICULUM_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_LUMEN.html The volume enclosed by the membranes of the endoplasmic reticulum. 194/258 Gene Ontology CC GO:0005788 1.79107696888887e-06 7.65586034975779e-06 105 193 200 1.62825311550243e-07 48 2.39802058153116 2.64827160934788 1 6.71084775293016 103 184 48 284 132 260 393 200 225 90 204 178 M17559 GO_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_COMPLEX.html Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 265/450 Gene Ontology CC GO:0043235 1.30800941913829e-13 3.61882605961595e-12 385 263 201 1.18909947194397e-14 14 2.36236850596338 2.35804927686375 1 14.877796347256 384 168 14 200 80 322 530 504 201 20 470 179 M17186 GO_BASAL_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PLASMA_MEMBRANE.html The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. 43/58 Gene Ontology CC GO:0009925 1.8936552419611e-05 3.30151694981917e-05 515 233.272727272727 202 1.72151958349103e-06 17 3.18208335012199 -4.22140948060796 -1 7.81275478831573 514 46 57 17 327 512 528 250 32 81 202 180 M17503 GO_SPERM_MIDPIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MIDPIECE.html The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. 12/16 Gene Ontology CC GO:0097225 1.81305894663648e-06 7.68895801456785e-06 100 202.818181818182 202 1.64823676437471e-07 96 1.62974300524696 1.28266977791463 1 4.53442881048444 393 108 202 138 100 288 245 96 264 245 152 181 M17762 GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 145/190 Gene Ontology CC GO:0019897 4.76467269653345e-06 1.26405243684289e-05 165 241.454545454545 202 4.33153001427616e-07 99 1.97830393871141 -1.97232619281282 -1 5.28440556389499 346 202 133 163 196 332 327 375 165 99 318 182 M17105 GO_CELL_CORTEX_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CORTEX_PART.html Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. 143/185 Gene Ontology CC GO:0044448 3.32439634709325e-06 1.0017642089771e-05 90 291.909090909091 203 3.02218306414859e-07 89 2.31984152055246 2.39669381999107 1 6.33966710531312 473 203 89 90 171 420 503 532 137 144 449 183 M17311 GO_EARLY_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding an early endosome. 144/194 Gene Ontology CC GO:0031901 5.05386231625839e-06 1.30501955810939e-05 210 182.636363636364 204 4.59443084189046e-07 53 1.74177689033273 -1.34327428893667 -1 4.63002902191226 210 206 240 53 202 145 220 204 161 275 93 184 M17416 GO_RUFFLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_MEMBRANE.html The portion of the plasma membrane surrounding a ruffle. 127/146 Gene Ontology CC GO:0032587 1.0318528135661e-06 6.94007103560441e-06 545 308.181818181818 205 9.38048452300146e-08 2 1.87983488479422 2.15487310471645 1 5.28838189753497 579 2 161 168 25 542 482 545 155 205 526 185 M17647 GO_MAIN_AXON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAIN_AXON.html The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. 68/108 Gene Ontology CC GO:0044304 5.35058786417127e-06 1.35160502134065e-05 445 263.545454545455 208 4.86418261572924e-07 29 2.4712965741885 2.67310234508687 1 6.58072766012246 441 29 74 104 208 461 565 405 112 68 432 186 M17839 GO_PRIMARY_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_LYSOSOME.html A lysosome before it has fused with a vesicle or vacuole. 18/68 Gene Ontology CC GO:0005766 0.000220070107573642 0.000282877726770544 195 235.090909090909 209 2.00083749709845e-05 96 1.6390125045239 -1.61318262772621 -1 3.14076519771156 144 96 209 220 435 193 166 237 463 193 230 187 M17133 GO_ANAPHASE_PROMOTING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX.html A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. 23/24 Gene Ontology CC GO:0005680 5.39736332785009e-06 1.3516672816728e-05 310 225.363636363636 210 4.9067059722732e-07 105 1.24704246680353 1.34512142570488 1 3.28248491385875 118 307 314 373 210 148 111 105 276 308 209 188 M16990 GO_CONDENSED_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONDENSED_NUCLEAR_CHROMOSOME.html A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. 89/221 Gene Ontology CC GO:0000794 8.26187575123047e-05 0.000118522217567035 25 189.636363636364 211 7.51107821260571e-06 20 1.70036179361394 1.8720845468714 1 3.61664619843631 20 294 257 309 413 25 23 68 389 211 77 189 M17253 GO_MOTILE_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM.html A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles. 90/165 Gene Ontology CC GO:0031514 5.12882247645537e-06 1.31851586673477e-05 215 243.545454545455 212 4.66257675748251e-07 95 1.52669257519466 1.47818131922944 1 4.04498912378483 212 213 296 535 204 159 193 95 327 259 186 190 M17270 GO_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an endocytic vesicle. 162/230 Gene Ontology CC GO:0030666 3.49426909513351e-06 1.03054332196577e-05 295 236.181818181818 212 3.17661331373446e-07 98 1.72861364456461 -1.54312158752151 -1 4.69253815664319 291 192 175 221 176 188 370 301 374 212 98 191 M17511 GO_MEMBRANE_MICRODOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_MICRODOMAIN.html A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. 360/491 Gene Ontology CC GO:0098857 3.44681349420786e-13 8.34416100056153e-12 470 268 212 3.13346681291673e-14 16 2.32039855768955 2.55017897942829 1 14.1463018762036 466 159 16 64 78 516 497 462 212 32 446 192 M17691 GO_PERIKARYON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIKARYON.html The portion of the cell soma (cell body) that excludes the nucleus. 120/202 Gene Ontology CC GO:0043204 1.65045351847812e-06 7.31995033767777e-06 550 248.636363636364 212 1.50041341514526e-07 69 2.41962834961192 -2.27695431225644 -1 6.79809893313289 547 212 69 93 84 458 348 251 113 140 420 193 M17251 GO_COMPACT_MYELIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPACT_MYELIN.html The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. 23/26 Gene Ontology CC GO:0043218 8.98809851780924e-06 1.87171513937175e-05 215 246.545454545455 213 8.17103203535428e-07 143 2.17329846745218 -2.20618077753666 -1 5.60788160506167 300 271 207 211 256 354 390 213 143 198 169 194 M17716 GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_OF_ENDOCYTIC_VESICLE.html A clathrin coat found on an endocytic vesicle. 15/17 Gene Ontology CC GO:0030128 5.72354401739105e-06 1.4031135333773e-05 325 223.636363636364 214 5.2032353707999e-07 8 1.60159551882298 -2.19419557333124 -1 4.22329642939638 321 101 258 57 214 387 462 109 8 399 144 195 M17722 GO_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSPORT_VESICLE.html Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. 369/538 Gene Ontology CC GO:0030133 1.2542645342896e-06 7.00306979348224e-06 315 220.909090909091 214 1.14024113579252e-07 53 1.9225461644773 -1.68478549959765 -1 5.40611560624305 311 160 112 128 53 259 302 503 214 80 308 196 M17145 GO_SPINDLE_POLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_POLE.html Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. 146/171 Gene Ontology CC GO:0000922 1.30797823799708e-05 2.47691855928236e-05 45 178.181818181818 215 1.18907819496144e-06 34 1.58443171440036 1.74859682448149 1 3.96083468716233 43 255 294 269 287 34 41 104 215 272 146 197 M17403 GO_GOLGI_ASSOCIATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE.html Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. 98/113 Gene Ontology CC GO:0005798 1.35112121280016e-06 7.1326376758392e-06 215 226.454545454545 215 1.22829276598779e-07 61 1.42203788577396 -1.18242059995066 -1 3.97236584449902 215 258 344 141 61 181 107 430 127 365 262 198 M17662 GO_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_VESICLE.html Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. 282/351 Gene Ontology CC GO:0030135 2.97759030079493e-06 9.2988912839913e-06 170 236.636363636364 216 2.70690393711143e-07 158 1.76827144485598 -1.42416033248977 -1 4.84563340398006 260 170 216 176 158 167 204 464 298 242 248 199 M17678 GO_SOMATODENDRITIC_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATODENDRITIC_COMPARTMENT.html The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon. 721/1027 Gene Ontology CC GO:0036477 5.22231003616881e-07 4.89380988873238e-06 320 236.545454545455 216 5.2223112634327e-08 37 2.24789007396366 2.51007878510273 1 6.52759779630992 317 140 567 67 111 216 475 284 166 37 222 200 M17731 GO_CILIARY_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PLASM.html All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. 74/119 Gene Ontology CC GO:0097014 7.56007192706512e-06 1.67648923268124e-05 190 232 216 6.87281627872139e-07 125 1.97573007531491 1.92648194333493 1 5.14336957221248 194 297 189 362 239 125 211 227 304 216 188 201 M17108 GO_GOLGI_STACK http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_STACK.html The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. 152/184 Gene Ontology CC GO:0005795 4.99133344138442e-06 1.30501955810939e-05 200 226.363636363636 217 4.53758615063404e-07 148 1.51817519575305 -1.21663798238267 -1 4.02574535404519 223 199 274 306 199 172 217 198 281 273 148 202 M17229 GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_ENDOPLASMIC_RETICULUM.html The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. 14/22 Gene Ontology CC GO:0097038 0.000417225778959345 0.000512285721839199 175 246.545454545455 217 3.79368114584309e-05 120 1.76073838118123 -1.93856073404415 -1 3.12848984585259 175 319 217 277 459 185 120 212 283 270 195 203 M17375 GO_MYOSIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOSIN_COMPLEX.html A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. 41/74 Gene Ontology CC GO:0016459 5.85484200483446e-06 1.42329004385306e-05 500 280.181818181818 217 5.32259780575968e-07 27 2.87801383526187 2.82959095658997 1 7.64071437596219 500 49 103 27 217 558 517 304 57 185 565 204 M17150 GO_NEURON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PART.html Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 1276/1803 Gene Ontology CC GO:0097458 1.90597888345431e-11 3.81853010788606e-10 350 222.363636363636 218 1.90597888347066e-12 8 2.1666987029456 2.39808537924601 1 11.2135030742862 348 122 517 8 55 218 485 255 181 21 236 205 M17295 GO_CILIARY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_PART.html Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 291/415 Gene Ontology CC GO:0044441 8.73799778740199e-07 6.94007103560441e-06 225 172.181818181818 218 7.94363750725172e-08 11 1.74457644759606 1.70296597359148 1 4.90232144650138 97 288 223 358 11 18 92 225 262 218 102 206 M17775 GO_SYNAPSE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_PART.html Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 586/866 Gene Ontology CC GO:0044456 4.71451361022582e-09 7.40306056092217e-08 360 244.454545454545 219 4.71451362022781e-10 24 2.1735983298545 2.51967798734234 1 8.49840163722507 357 142 576 66 107 235 529 242 192 24 219 207 M17302 GO_BASEMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE.html A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. 112/132 Gene Ontology CC GO:0005604 1.53197837608143e-17 5.23576139119595e-16 10 200.181818181818 220 1.39270761461948e-18 8 2.88470233233841 3.09517524034385 1 24.3127421066136 8 211 11 246 440 220 354 224 289 22 177 208 M17765 GO_TERMINAL_BOUTON http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINAL_BOUTON.html Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. 63/105 Gene Ontology CC GO:0043195 6.30384315572552e-06 1.50721517427018e-05 260 231.272727272727 222 5.73078292611326e-07 37 1.93387077259106 -1.66480525716289 -1 5.0822255422823 401 37 143 112 222 257 197 438 260 167 310 209 M17077 GO_BASAL_LAMINA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_LAMINA.html A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. 40/46 Gene Ontology CC GO:0005605 1.95605506195458e-08 2.52548442443469e-07 15 219.090909090909 223 1.77823189031471e-09 15 2.89869911128564 2.86263445327562 1 10.5044147856749 15 223 33 203 467 226 388 359 294 43 159 210 M17098 GO_EXOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE.html A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. 150/211 Gene Ontology CC GO:0070382 9.94671577493343e-07 6.94007103560441e-06 335 220.909090909091 223 9.04247297461787e-08 21 2.01884682530887 -1.84063822583666 -1 5.68515575923141 334 196 104 131 21 290 366 466 242 57 223 211 M17840 GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_RICH_LIPOPROTEIN_PARTICLE.html A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood. 15/34 Gene Ontology CC GO:0034385 2.03534114287587e-06 8.00162624298156e-06 560 262.090909090909 223 1.85031184171315e-07 6 2.41029367173784 -2.63190769037698 -1 6.72000449723533 558 105 146 19 114 518 436 223 6 226 532 212 M17090 GO_MHC_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. 30/50 Gene Ontology CC GO:0042611 5.61627499284845e-05 8.4754695346622e-05 40 232.363636363636 224 5.1058348847059e-06 40 1.4102715131636 -1.32742358892483 -1 3.10010949477588 40 224 235 241 370 107 198 312 453 169 207 213 M17187 GO_MCM_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MCM_COMPLEX.html A hexameric protein complex required for the initiation and regulation of DNA replication. 11/11 Gene Ontology CC GO:0042555 0.00197412037240017 0.00227572209596131 40 231.363636363636 224 0.000179626730305541 38 1.66140188331813 1.66140188331813 1 2.35232831046175 38 320 224 294 498 122 50 201 380 150 268 214 M17746 GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. 15/34 Gene Ontology CC GO:0034361 2.03534114287587e-06 8.00162624298156e-06 560 263 225 1.85031184171315e-07 5 2.41029367173784 -2.63190769037698 -1 6.72000449723533 557 104 145 18 113 517 435 243 5 225 531 215 M17409 GO_CHLORIDE_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_CHANNEL_COMPLEX.html An ion channel complex through which chloride ions pass. 20/50 Gene Ontology CC GO:0034707 6.58955714525181e-06 1.54811478751154e-05 545 273.909090909091 226 5.99052443884274e-07 10 2.91826283794944 2.53341830167966 1 7.68969754160482 543 79 106 74 226 564 427 272 10 160 552 216 M17828 GO_MHC_CLASS_I_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_I_PROTEIN_COMPLEX.html A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. 22/39 Gene Ontology CC GO:0042612 0.00037032465423873 0.000460725105166385 15 235.090909090909 227 3.36715459505e-05 14 1.07572717837907 -1.06734108817112 -1 1.90877407910438 14 80 289 279 454 108 154 217 495 269 227 217 M16986 GO_ENDOLYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME.html An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. 35/66 Gene Ontology CC GO:0036019 9.26390363655225e-06 1.91541922165013e-05 345 226 228 8.42176604166591e-07 62 2.27885484609754 -2.38346641831396 -1 5.87136126701107 342 62 153 212 259 373 295 132 118 312 228 218 M17674 GO_PRESYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPSE.html The part of a synapse that is part of the presynaptic cell. 272/414 Gene Ontology CC GO:0098793 1.5325276664353e-06 7.17131502932038e-06 440 254.454545454545 228 1.39320794000041e-07 62 1.94893956618979 -1.82595635844866 -1 5.47027345162993 439 169 98 127 76 353 415 557 228 62 275 219 M17737 GO_COHESIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_COHESIN_COMPLEX.html A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). 10/14 Gene Ontology CC GO:0008278 1.4510531375094e-05 2.6934884117986e-05 115 255.454545454545 228 1.31914791663933e-06 113 2.11630652291784 2.42010609698555 1 5.27370293154764 113 384 228 337 296 215 115 559 149 253 161 220 M17169 GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ASSOCIATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. 54/63 Gene Ontology CC GO:0030660 1.20968281874748e-06 6.94007103560441e-06 290 183.454545454545 229 1.09971225809012e-07 43 1.52502008331397 -1.39014409449166 -1 4.27565422501146 290 43 305 51 48 270 105 257 77 343 229 221 M17036 GO_NUCLEAR_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE.html The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. 21/30 Gene Ontology CC GO:0005640 2.2903080328768e-06 8.47322892374399e-06 400 238.818181818182 232 2.08210037927582e-07 53 1.62016510012474 -1.97013028888322 -1 4.46951435766857 398 272 218 232 123 487 386 134 62 262 53 222 M17139 GO_MYOFILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFILAMENT.html Any of the smallest contractile units of a myofibril (striated muscle fiber). 19/34 Gene Ontology CC GO:0036379 3.77325102466263e-07 3.71569295818473e-06 345 255.545454545455 232 3.43022879256218e-08 5 2.77253054935868 3.99918367482844 1 8.25257018034695 345 232 120 248 344 523 560 5 94 208 132 223 M17280 GO_AXONAL_GROWTH_CONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_GROWTH_CONE.html The migrating motile tip of a growing nerve cell axon. 37/44 Gene Ontology CC GO:0044295 7.21356282674379e-06 1.65003149698352e-05 275 231.636363636364 232 6.55780589031565e-07 54 2.15486144643047 2.59218346573888 1 5.62492721504769 203 54 130 174 232 271 343 461 238 170 272 224 M17154 GO_ROUGH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM.html The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. 79/110 Gene Ontology CC GO:0005791 8.9358801854677e-07 6.94007103560441e-06 555 278.090909090909 234 8.12353074092105e-08 13 2.41969453460707 2.51037614923454 1 6.82927253784485 552 214 134 103 13 492 342 417 90 234 468 225 M17160 GO_MICROBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY.html Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 142/169 Gene Ontology CC GO:0042579 7.39332114667417e-06 1.6649300721774e-05 370 255.636363636364 235 6.72122362980905e-07 84 1.54293198135142 -1.44866089738411 -1 4.00234757211465 84 390 343 368 235 131 126 192 367 363 213 226 M17533 GO_MIDBODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBODY.html A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. 172/198 Gene Ontology CC GO:0030496 1.06766081944175e-06 6.94007103560441e-06 230 257.454545454545 235 9.70601215980269e-08 28 1.69060371070637 1.98136827931647 1 4.74827013865857 362 188 229 229 28 337 414 358 151 235 301 227 M17282 GO_APICAL_DENDRITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_DENDRITE.html A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. 21/30 Gene Ontology CC GO:0097440 4.39087997833581e-05 6.83941358555793e-05 360 319.181818181818 236 3.99178874214709e-06 141 2.71933437101714 3.1617174290732 1 6.18947243472178 555 231 141 164 357 536 357 216 146 236 572 228 M17003 GO_MICROTUBULE_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON.html The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. 1124/1355 Gene Ontology CC GO:0015630 2.00859598141601e-06 8.00162624298156e-06 190 249.272727272727 238 2.00859779692434e-07 58 1.60646131909344 1.70095999979145 1 4.45316389455904 187 246 511 481 122 58 178 238 256 276 189 229 M17553 GO_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATION_FORK.html The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 74/81 Gene Ontology CC GO:0005657 0.000374892504844731 0.000464917372386914 20 218.181818181818 239 3.40869458093855e-05 16 1.64615438813812 1.77309996025999 1 2.95825558643967 16 332 271 366 455 53 27 154 239 261 226 230 M17521 GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_THE_CYTOPLASMIC_SIDE_OF_THE_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. 12/14 Gene Ontology CC GO:0031235 2.56354697952464e-06 8.89573661322095e-06 525 291.636363636364 240 2.33049996972647e-07 31 2.58263474689064 2.38486239455134 1 7.14027625681722 524 240 155 161 141 428 491 258 31 206 573 231 M17734 GO_ESCRT_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESCRT_III_COMPLEX.html An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. 12/12 Gene Ontology CC GO:0000815 8.84192445512167e-06 1.86959727212026e-05 35 201.181818181818 241 8.03814544683291e-07 5 0.832538952547175 -0.832538952547175 -1 2.10089310173095 33 241 332 396 252 50 5 40 423 410 31 232 M17198 GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_OUTER_SEGMENT_MEMBRANE.html The membrane surrounding the outer segment of a vertebrate photoreceptor. 11/19 Gene Ontology CC GO:0042622 2.65278046512457e-06 8.90904884530275e-06 370 263.454545454545 242 2.41162151261576e-07 12 1.95797078811409 -2.02251393061146 -1 5.39389433538131 366 242 201 214 341 433 356 12 189 305 239 233 M17199 GO_HOPS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOPS_COMPLEX.html A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. 16/16 Gene Ontology CC GO:0030897 8.9135704712102e-06 1.86959727212026e-05 30 199.636363636364 242 8.1032787144015e-07 6 1.10021623610362 -1.10021623610362 -1 2.80116739207382 35 344 336 242 412 42 6 29 355 366 29 234 M17635 GO_CELL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_BODY.html The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. 535/774 Gene Ontology CC GO:0044297 2.31381376728099e-06 8.47322892374399e-06 370 259.454545454545 242 2.31381617646488e-07 64 2.26901240556766 2.46428737320837 1 6.29036203544611 367 144 561 70 138 242 480 336 167 64 285 235 M17084 GO_NEURON_PROJECTION_TERMINUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_TERMINUS.html The specialized, terminal region of a neuron projection such as an axon or a dendrite. 136/226 Gene Ontology CC GO:0044306 8.23794134580954e-06 1.79933982026893e-05 380 280 244 7.48906563008857e-07 78 2.18442071710198 2.70980336943146 1 5.65767528000255 379 209 85 169 244 436 561 423 258 78 238 236 M17398 GO_EXTRACELLULAR_MATRIX_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_COMPONENT.html Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). 144/171 Gene Ontology CC GO:0044420 9.27888469886161e-21 4.49252667503216e-19 245 218.454545454545 245 8.43534972623784e-22 7 2.87843561559168 3.17178767856614 1 29.1435142772121 13 254 7 245 446 250 394 241 343 19 191 237 M17592 GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_GATED_CHANNEL_COMPLEX.html A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. 4/20 Gene Ontology CC GO:0005892 7.21449147987361e-07 6.35093871182813e-06 260 217.636363636364 245 7.21449382207461e-08 6 2.59116086386095 -3.67500716948362 -1 7.37391283115395 259 245 555 191 340 252 165 6 21 282 78 238 M17111 GO_CD40_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD40_RECEPTOR_COMPLEX.html A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. 15/16 Gene Ontology CC GO:0035631 0.000294472103543899 0.000372741377252735 155 251.818181818182 246 2.67737751185638e-05 99 1.68870721232112 -1.86846717810319 -1 3.12638767853433 246 99 176 272 444 263 163 535 267 151 154 239 M17451 GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE.html The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. 66/89 Gene Ontology CC GO:0012507 6.7269068571486e-06 1.56961160000134e-05 260 231.090909090909 247 6.11538856908946e-07 107 1.58301873089515 -1.38444517072359 -1 4.13076160149904 141 216 260 262 228 231 257 107 302 291 247 240 M17453 GO_PRESYNAPTIC_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_MEMBRANE.html A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. 53/95 Gene Ontology CC GO:0042734 8.59437518826059e-06 1.84938221643682e-05 475 281.363636363636 249 7.81309887514964e-07 40 2.06029643040954 1.78635304364896 1 5.31822878079856 472 40 147 185 249 393 554 106 271 114 564 241 M17223 GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUGH_ENDOPLASMIC_RETICULUM_MEMBRANE.html The lipid bilayer surrounding the rough endoplasmic reticulum. 25/30 Gene Ontology CC GO:0030867 8.4908083844588e-06 1.84073122066066e-05 305 235.454545454545 253 7.71894650414294e-07 133 1.8527638997128 -2.04341122891618 -1 4.77684533748536 266 304 253 175 247 273 136 247 133 301 255 242 M17306 GO_PLATELET_DENSE_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_TUBULAR_NETWORK.html A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. 13/14 Gene Ontology CC GO:0031094 5.69146636069435e-06 1.40116184557772e-05 255 294.454545454545 254 5.17407371340258e-07 110 2.11036671131148 -1.36973051978251 -1 5.59009619784559 533 318 166 254 213 477 253 339 110 152 424 243 M17356 GO_PERICENTRIC_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIC_HETEROCHROMATIN.html Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. 17/18 Gene Ontology CC GO:0005721 8.88556513973563e-06 1.86959727212026e-05 75 237.818181818182 254 8.07781911617053e-07 28 1.50064820719775 1.61905555082022 1 3.8487430797186 71 486 291 466 254 73 28 79 403 379 86 244 M17446 GO_VACUOLAR_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_LUMEN.html The volume enclosed within the vacuolar membrane. 116/197 Gene Ontology CC GO:0005775 2.50941617279459e-06 8.84092843240716e-06 375 253.636363636364 255 2.28129003195358e-07 5 1.98610406375444 -1.85505610120565 -1 5.47616828362521 375 5 168 227 134 304 352 455 280 255 235 245 M17582 GO_RECYCLING_ENDOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECYCLING_ENDOSOME_MEMBRANE.html The lipid bilayer surrounding a recycling endosome. 47/51 Gene Ontology CC GO:0055038 3.8333357267336e-06 1.10255844417437e-05 260 253.727272727273 256 3.48485673277378e-07 164 1.63646476217044 -1.58935960895776 -1 4.41171557017108 216 222 259 237 180 309 164 378 275 295 256 246 M17841 GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_SUBCOMPARTMENT.html A distinct region of the endoplasmic reticulum 21/22 Gene Ontology CC GO:0098827 2.73567520745721e-06 9.05388556760966e-06 385 270.454545454545 256 2.48698055385857e-07 68 1.4297960767822 1.8579220186223 1 3.91251285083228 385 82 256 234 147 386 458 566 105 288 68 247 M17208 GO_M_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_M_BAND.html The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. 28/40 Gene Ontology CC GO:0031430 9.02208322554996e-06 1.87208226930162e-05 425 235.818181818182 257 8.20192747713347e-07 43 1.93799236634724 1.67611408923923 1 4.99226669953652 425 73 198 137 257 397 332 165 43 302 265 248 M17608 GO_PHAGOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a phagocytic vesicle. 74/111 Gene Ontology CC GO:0030670 1.14725421824315e-05 2.2595074603365e-05 40 200.090909090909 260 1.04296381907166e-06 40 1.32354521897524 -1.40379675975894 -1 3.32517748419024 51 260 283 261 273 40 142 73 424 354 40 249 M17832 GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the nucleus. 43/47 Gene Ontology CC GO:0000152 9.36466448480291e-06 1.9293865481101e-05 135 284.454545454545 260 8.51336758844212e-07 95 1.11580174408173 1.30614488930781 1 2.83350072825268 133 474 374 490 260 121 95 167 442 352 221 250 M17246 GO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME.html A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. 553/639 Gene Ontology CC GO:0005813 2.57809133267918e-06 8.89573661322095e-06 105 244.727272727273 261 2.57809432363378e-07 32 1.52369320069422 1.57106796622551 1 4.18097096153549 105 325 523 416 150 32 94 261 300 311 175 251 M17240 GO_POTASSIUM_CHANNEL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_CHANNEL_COMPLEX.html An ion channel complex through which potassium ions pass. 57/123 Gene Ontology CC GO:0034705 3.707677648533e-09 5.9837797605491e-08 35 227.909090909091 262 3.37061604980143e-10 26 2.94329989637201 3.16408473217015 1 11.6856476064447 414 35 26 86 262 385 408 351 213 34 293 252 M17127 GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinase (CDK) complex found in the nucleus. 16/20 Gene Ontology CC GO:0019908 0.00320957269076504 0.0036068892327553 185 300.909090909091 265 0.00029220588288586 172 0.992009929122247 -1.16759692364178 -1 1.26370077706947 184 317 347 243 520 265 224 230 172 481 327 253 M17371 GO_INTRACELLULAR_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_VESICLE.html Any vesicle that is part of the intracellular region. 1266/1799 Gene Ontology CC GO:0097708 1.52575333221905e-06 7.17131502932038e-06 275 245 265 1.52575437978551e-07 46 1.99239643886891 -1.77066940204626 -1 5.59396765765481 298 124 532 265 87 191 273 398 273 46 208 254 M17640 GO_ESC_E_Z_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESC_E_Z_COMPLEX.html A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. 19/20 Gene Ontology CC GO:0035098 7.86067609621567e-05 0.000113045861680725 275 262 265 7.14632452267444e-06 130 1.3368069699868 1.45714338222562 1 2.84207636674712 265 273 304 259 390 245 275 130 235 330 176 255 M17675 GO_A_BAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_A_BAND.html The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. 45/72 Gene Ontology CC GO:0031672 1.18046255443503e-06 6.94007103560441e-06 45 288.818181818182 265 1.07314835258262e-07 42 1.90623507862906 1.85886584833264 1 5.36373446666397 482 48 179 43 42 505 534 528 56 265 495 256 M16980 GO_AGGRESOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGGRESOME.html An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. 38/47 Gene Ontology CC GO:0016235 1.22627481138927e-06 6.94007103560441e-06 240 273.727272727273 266 1.1147959044659e-07 50 1.36983051029321 -1.30791023732094 -1 3.83270546856288 236 266 279 465 50 238 229 433 318 384 113 257 M17763 GO_AXON_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_PART.html A part of an axon, a cell projection of a neuron. 248/371 Gene Ontology CC GO:0033267 4.87134929887963e-06 1.28065789260139e-05 410 266.454545454545 266 4.42850916845155e-07 45 2.15186431366977 2.6149276138187 1 5.74803429842493 408 176 62 166 198 426 562 331 266 45 291 258 M17460 GO_COP9_SIGNALOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_COP9_SIGNALOSOME.html A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. 43/56 Gene Ontology CC GO:0008180 4.02936471255822e-06 1.13094729371803e-05 255 261.909090909091 267 3.66306553861558e-07 47 1.80419961802021 1.55403243674497 1 4.86079250651054 254 406 267 47 185 205 106 390 274 369 378 259 M16999 GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFIID_COMPLEX.html A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. 24/29 Gene Ontology CC GO:0005669 0.000160611680755058 0.000212563522821614 280 283 268 1.46021279508258e-05 25 1.83506775859419 2.21091204226041 1 3.65169524566227 280 410 268 260 422 249 231 240 25 444 284 260 M17610 GO_PHOTORECEPTOR_INNER_SEGMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_INNER_SEGMENT.html The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. 35/55 Gene Ontology CC GO:0001917 2.58757226787322e-06 8.89573661322095e-06 440 311.545454545455 268 2.35234119209188e-07 61 1.95803200624773 1.79927251706529 1 5.39476895807046 576 61 173 194 142 446 440 268 439 200 488 261 M17708 GO_BAF_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BAF_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family. 20/23 Gene Ontology CC GO:0090544 0.000375294746384617 0.000464917372386914 110 269.272727272727 271 3.41235256958444e-05 110 1.40154671639172 1.15789722924837 1 2.50721826676174 110 311 307 239 456 182 271 292 176 375 243 262 M17798 GO_BASAL_PART_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASAL_PART_OF_CELL.html The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. 63/84 Gene Ontology CC GO:0045178 8.80733666666019e-06 1.86959727212026e-05 55 267.545454545455 271 8.00670175052328e-07 30 2.73831394722667 -3.55180709416655 -1 7.08661775576545 517 30 53 120 271 568 535 352 51 88 358 263 M16981 GO_MULTIVESICULAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY.html A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 37/51 Gene Ontology CC GO:0005771 1.12943304849022e-05 2.23959249547037e-05 295 226 272 1.02676258800012e-06 29 2.41002824551033 -2.21698269983961 -1 6.12321418424911 294 53 116 29 272 356 314 480 39 196 337 264 M17713 GO_SWI_SNF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_COMPLEX.html A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components. 13/15 Gene Ontology CC GO:0016514 9.27038713001446e-05 0.000129162947782695 205 256.636363636364 273 8.42797980888825e-06 34 1.2904487159784 0.926506877143149 1 2.69951480994664 204 279 297 235 400 178 256 291 34 376 273 265 M17623 GO_ACROSOMAL_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_VESICLE.html A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. 80/154 Gene Ontology CC GO:0001669 9.99123406515149e-06 2.03306834829652e-05 250 303.363636363636 274 9.08298130939096e-07 201 1.98381915621104 -1.79129676652838 -1 5.07281513931981 248 430 220 424 265 274 303 300 402 201 270 266 M17528 GO_SCHMIDT_LANTERMAN_INCISURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHMIDT_LANTERMAN_INCISURE.html Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. 18/21 Gene Ontology CC GO:0043220 1.66968546197889e-05 3.01269333357061e-05 335 268.818181818182 275 1.5179073946881e-06 81 2.15793950484869 -2.10799061600585 -1 5.32089218661937 335 275 219 136 303 421 488 309 157 233 81 267 M17407 GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_GOLGI_MEMBRANE.html The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 53/65 Gene Ontology CC GO:0031228 6.39067374106797e-06 1.51550263002469e-05 290 273.636363636364 276 5.80972027736632e-07 191 1.99842559069598 2.44296991872617 1 5.25181732580096 289 300 191 360 224 256 212 318 352 232 276 268 M17073 GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_RECEPTOR_COMPLEX.html Any protein complex that is part of the plasma membrane and which functions as a receptor. 134/236 Gene Ontology CC GO:0098802 5.76833077420868e-09 8.59333379439806e-08 30 295.818181818182 277 5.24393708121189e-10 20 2.40101011412236 2.33702874894404 1 9.30959366549019 578 204 28 20 90 471 559 513 277 28 486 269 M17165 GO_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_NUCLEUS.html The nucleus of a germ cell, a reproductive cell in multicellular organisms. 20/37 Gene Ontology CC GO:0043073 0.00181036898392945 0.0020994498596068 210 300.181818181818 277 0.000164714586002516 108 1.79202457516291 1.93968000229343 1 2.57805330475381 208 417 226 371 491 173 108 270 461 277 300 270 M17616 GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_QUALITY_CONTROL_COMPARTMENT.html A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. 14/15 Gene Ontology CC GO:0044322 0.00166072811125219 0.00193363333193893 105 254.818181818182 277 0.000151089371111034 74 0.986524527014275 -0.90745682946197 -1 1.40407701306777 102 277 317 339 490 165 74 297 180 347 215 271 M17714 GO_CYTOPLASMIC_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE.html Any microtubule in the cytoplasm of a cell. 66/84 Gene Ontology CC GO:0005881 1.9943378982947e-05 3.42813703819297e-05 280 233.363636363636 277 1.81305088867341e-06 32 2.15371196280562 2.26648601956446 1 5.24346246744645 277 32 152 159 316 280 284 412 135 172 348 272 M17055 GO_ZYMOGEN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_GRANULE.html A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. 21/28 Gene Ontology CC GO:0042588 1.87812913473844e-05 3.28672598579227e-05 265 280 278 1.70740469856885e-06 200 1.97982803132921 -1.81781986758095 -1 4.83393555582708 225 309 200 216 311 347 261 388 282 263 278 273 M17209 GO_NPBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NPBAF_COMPLEX.html A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. 14/15 Gene Ontology CC GO:0071564 6.73068530327869e-05 9.82544764121839e-05 70 238.272727272727 278 6.11899202804307e-06 65 0.917546967447353 0.917546967447353 1 1.95745217537866 69 278 341 298 461 87 183 65 321 391 127 274 M17430 GO_SYNAPTONEMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX.html A proteinaceous scaffold found between homologous chromosomes during meiosis. 31/151 Gene Ontology CC GO:0000795 0.000167552289093047 0.000221245181734228 165 272.727272727273 278 1.52331864780162e-05 12 1.57912126774986 1.686015385477 1 3.11642770947496 164 477 292 431 483 85 36 246 496 278 12 275 M17838 GO_CHYLOMICRON http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHYLOMICRON.html A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. 5/15 Gene Ontology CC GO:0042627 1.06278835671499e-05 2.1219245197643e-05 510 302.090909090909 278 1.06279343958512e-06 53 1.93818377038672 -1.46322220195719 -1 4.93442422850766 510 244 580 184 278 363 53 313 76 186 536 276 M17313 GO_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 264/357 Gene Ontology CC GO:0005667 1.01948405791314e-05 2.06383358065344e-05 260 348 279 9.26807983865201e-07 212 1.47259820533829 1.63221467935371 1 3.74038533756549 258 466 429 536 267 212 279 277 398 446 260 277 M17741 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding a clathrin-coated endocytic vesicle. 42/55 Gene Ontology CC GO:0030669 2.63674306184428e-06 8.90667278448563e-06 505 326.909090909091 279 2.39704202003432e-07 51 1.88062783578024 1.79699004418745 1 5.17790098201451 503 51 203 142 145 501 484 552 179 279 557 278 M17401 GO_TCTN_B9D_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TCTN_B9D_COMPLEX.html A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins. 12/12 Gene Ontology CC GO:0036038 3.38947601757613e-05 5.47023768392148e-05 55 243.636363636364 280 3.08138930852161e-06 46 1.250221249966 1.250221249966 1 2.8710681775431 93 423 308 484 436 74 46 55 427 280 54 279 M17757 GO_NBAF_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NBAF_COMPLEX.html A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. 14/16 Gene Ontology CC GO:0071565 0.00015004627025027 0.000199489434817865 90 245.636363636364 280 1.36415004373455e-05 86 1.22582471568245 1.22582471568245 1 2.43242457402901 86 280 310 319 437 120 175 93 356 392 134 280 M17007 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE.html A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes. 32/33 Gene Ontology CC GO:0000407 1.25001875354885e-05 2.39690064624383e-05 80 270.181818181818 282 1.13638714190108e-06 45 0.978189612288134 -1.06753153964972 -1 2.42353242188045 80 356 408 491 282 91 45 274 413 462 70 281 M17566 GO_GAMMA_TUBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_TUBULIN_COMPLEX.html A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. 22/25 Gene Ontology CC GO:0000930 0.000181941105657973 0.000237012964993907 285 287.454545454545 282 1.65414685473808e-05 159 1.59091181017836 1.83384590026649 1 3.11395470086569 331 340 281 346 428 282 168 159 243 327 257 282 M17718 GO_PIGMENT_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE.html A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. 115/141 Gene Ontology CC GO:0048770 8.7660635357258e-06 1.86959727212026e-05 285 280.727272727273 282 7.96918042268402e-07 110 1.9386070277656 -1.71791652072021 -1 4.9944932838366 282 393 230 110 251 316 234 404 248 296 324 283 M17168 GO_LUMENAL_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUMENAL_SIDE_OF_MEMBRANE.html Any side (leaflet) of a membrane that faces the lumen of an organelle. 43/66 Gene Ontology CC GO:0098576 0.000114867202629253 0.000155810682437693 110 260.818181818182 285 1.04430182323619e-05 83 1.37088753224114 -1.30888294171493 -1 2.81080657324735 108 334 288 244 410 83 137 364 491 285 125 284 M17239 GO_GOLGI_APPARATUS_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS_PART.html Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. 903/1202 Gene Ontology CC GO:0044431 1.09916910015109e-06 6.94007103560441e-06 360 276.545454545455 285 1.09916964382919e-07 47 1.85616206149164 -1.62530431275885 -1 5.22081390672606 359 133 522 285 47 269 287 396 208 213 323 285 M17384 GO_CELL_SUBSTRATE_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION.html A cell junction that forms a connection between a cell and the extracellular matrix. 532/642 Gene Ontology CC GO:0030055 9.8257350064864e-07 6.94007103560441e-06 290 323.636363636364 287 9.82573935101716e-08 29 1.84093971051773 2.18419323564861 1 5.17736561762475 415 286 534 247 29 456 569 287 216 210 311 286 M17601 GO_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL.html Extracellular matrix material consisting of polysaccharides and protein. 16/23 Gene Ontology CC GO:0043205 0.000133742580647808 0.00017987138739902 100 287.181818181818 287 1.21591556208907e-05 90 2.90425030876838 3.73263387572141 1 5.94079503982836 422 98 99 287 473 579 312 90 468 163 168 287 M17442 GO_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATPASE_COMPLEX.html A protein complex which is capable of ATPase activity. 24/33 Gene Ontology CC GO:1904949 0.000130011783808172 0.000175667084633832 560 326.818181818182 288 1.18199516049798e-05 88 2.41381510853866 -2.15445744778728 -1 4.93827895277147 556 362 159 256 417 547 476 88 288 179 267 288 M17005 GO_LYSOSOMAL_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_LUMEN.html The volume enclosed within the lysosomal membrane. 93/120 Gene Ontology CC GO:0043202 1.46740439553952e-06 7.1326376758392e-06 550 311.727272727273 289 1.33400488572918e-07 14 1.91902711559576 -1.57655940312932 -1 5.38762539269691 549 14 178 289 71 549 573 232 331 224 419 289 M17235 GO_GOLGI_CISTERNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA.html Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. 115/145 Gene Ontology CC GO:0031985 8.86054414598666e-06 1.86959727212026e-05 285 280.454545454545 289 8.05507257473384e-07 4 1.55814528005737 -1.20229193200677 -1 3.99916197727543 310 4 265 363 253 289 336 386 315 283 281 290 M17327 GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COATED_ENDOCYTIC_VESICLE.html A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. 55/77 Gene Ontology CC GO:0045334 6.11769728032412e-06 1.47484735264245e-05 220 311.363636363636 290 5.56155844755321e-07 143 1.90625614872021 -1.86445441997899 -1 5.01849693644333 428 219 196 143 220 411 423 516 290 258 321 291 M17825 GO_EXOCYTIC_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTIC_VESICLE_MEMBRANE.html The lipid bilayer surrounding an exocytic vesicle 55/80 Gene Ontology CC GO:0099501 9.78418367360064e-07 6.94007103560441e-06 315 210.818181818182 290 8.89471638634395e-08 17 2.23604609306481 -2.08054142386952 -1 6.30509525440076 314 38 92 130 17 378 290 333 306 70 351 292 M17766 GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORED_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. 34/45 Gene Ontology CC GO:0046658 1.06005867474337e-06 6.94007103560441e-06 50 266.636363636364 291 9.63690168661396e-08 15 3.10469789615657 2.86009581586931 1 8.78443860509644 553 50 43 15 291 482 513 442 54 48 442 293 M17038 GO_CATION_TRANSPORTING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORTING_ATPASE_COMPLEX.html Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 14/21 Gene Ontology CC GO:0090533 1.13599429371255e-05 2.24494110424148e-05 520 316.909090909091 292 1.03272741780631e-06 32 2.09466381061117 -2.62014202851752 -1 5.31066785510108 516 276 148 292 393 557 493 32 410 135 234 294 M17166 GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PLASMA_MEMBRANE.html The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 1096/2062 Gene Ontology CC GO:0031226 4.19059644740749e-73 2.43473653594375e-70 415 296.090909090909 292 4.19059644740759e-74 1 2.59827424732744 2.72261196434161 1 100 412 125 519 117 46 292 541 564 199 1 441 295 M17273 GO_BLOOD_MICROPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_MICROPARTICLE.html A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. 140/447 Gene Ontology CC GO:0072562 3.29234355270086e-07 3.35588000722667e-06 295 274.545454545455 292 2.99304004127882e-08 40 2.83564248794204 -2.5828673495258 -1 8.51158121794636 202 292 40 328 293 296 270 546 320 159 274 296 M17642 GO_NUCLEAR_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PERIPHERY.html The portion of the nuclear lumen proximal to the inner nuclear membrane. 137/182 Gene Ontology CC GO:0034399 1.9210147348309e-05 3.32865031317194e-05 315 274.727272727273 293 1.74639228101456e-06 63 1.99290100556365 2.14037910292893 1 4.86029391417365 226 392 244 336 313 312 293 156 63 418 269 297 M17195 GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_INVOLVED_IN_CELL_ADHESION.html Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. 28/43 Gene Ontology CC GO:0098636 2.25237256771122e-05 3.81524332898023e-05 300 220.818181818182 294 2.04763238905524e-06 33 2.38135930374933 2.60411527477351 1 5.74462770482932 299 68 108 33 321 294 367 316 203 105 315 298 M17477 GO_ENDOLYSOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOLYSOSOME_MEMBRANE.html The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. 29/50 Gene Ontology CC GO:0036020 2.34353528027795e-05 3.92390201107057e-05 465 284.545454545455 294 2.13050931363912e-06 101 2.16440416900717 -2.0474805042473 -1 5.1996283908089 461 268 187 177 324 495 377 101 107 339 294 299 M17680 GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE.html The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. 179/420 Gene Ontology CC GO:0009897 5.76303084164222e-14 1.67416045949707e-12 375 256.363636363636 295 5.2391189469476e-15 5 2.72273771967615 2.67063508438054 1 17.6634289607582 372 186 13 201 5 321 522 441 295 26 438 300 M17750 GO_MICROTUBULE_ORGANIZING_CENTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER.html An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. 703/819 Gene Ontology CC GO:0005815 2.32601051361923e-06 8.47322892374399e-06 325 275.636363636364 295 2.32601294826903e-07 55 1.49809114548396 1.58441027107706 1 4.12694057342046 168 324 574 482 140 55 157 295 309 323 205 301 M17768 GO_MAST_CELL_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_GRANULE.html Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. 22/48 Gene Ontology CC GO:0042629 1.5071435613012e-05 2.77104559846835e-05 420 296.909090909091 295 1.37013989665192e-06 49 2.00683053825074 -2.48185496613198 -1 4.98321683051931 418 229 172 305 298 556 566 49 156 222 295 302 M17097 GO_COATED_PIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COATED_PIT.html A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. 81/85 Gene Ontology CC GO:0005905 1.51214913502582e-05 2.77147838312303e-05 300 263.272727272727 296 1.37469048067227e-06 54 1.87636162794796 -1.82635357782343 -1 4.65416143189811 305 295 237 54 299 369 333 202 196 310 296 303 M17624 GO_PSEUDOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOPODIUM.html A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. 19/28 Gene Ontology CC GO:0031143 9.98532120450233e-07 6.94007103560441e-06 435 286.818181818182 297 9.07756885147745e-08 22 2.01903093742891 -2.05332719327747 -1 5.68568125996598 435 234 208 50 22 464 376 448 74 297 547 304 M17438 GO_GOLGI_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the Golgi apparatus. 761/943 Gene Ontology CC GO:0000139 1.35951660415435e-06 7.1326376758392e-06 330 288.272727272727 299 1.3595174358835e-07 74 1.77630751686737 -1.51541896541114 -1 4.98120758181647 374 137 540 329 74 293 299 330 209 267 319 305 M17399 GO_NUCLEAR_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_HETEROCHROMATIN.html A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. 37/40 Gene Ontology CC GO:0005720 7.4732284934676e-05 0.000107740589446766 190 282.454545454545 300 6.79407487753366e-06 56 1.36118399802362 1.36879966538472 1 2.91103068823457 186 441 300 428 388 153 84 221 472 378 56 306 M17550 GO_INTRACILIARY_TRANSPORT_PARTICLE_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT_PARTICLE_B.html The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. 22/24 Gene Ontology CC GO:0030992 1.48884147469305e-05 2.74608538665607e-05 45 216.636363636364 300 1.35350140951409e-06 3 1.33869423189191 1.33869423189191 1 3.3013827158934 41 367 319 489 348 15 18 38 445 300 3 307 M17064 GO_DNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_POLYMERASE_COMPLEX.html A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. 13/13 Gene Ontology CC GO:0042575 9.81683737133919e-06 2.00830370167186e-05 395 305.636363636364 301 8.92443743299349e-07 206 1.38559537567916 1.78570304303101 1 3.52392351512825 392 347 301 316 264 275 248 206 434 334 245 308 M17315 GO_MYELIN_SHEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_SHEATH.html An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. 237/303 Gene Ontology CC GO:0043209 1.30880206144524e-05 2.47691855928236e-05 290 383.363636363636 301 1.18982713427709e-06 218 1.74427544964591 1.83106703865734 1 4.36819989412267 520 290 269 218 288 488 539 465 301 290 549 309 M17385 GO_CILIARY_TRANSITION_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIARY_TRANSITION_ZONE.html A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition. 25/25 Gene Ontology CC GO:0035869 1.55851803398522e-05 2.82968430545441e-05 50 235.363636363636 301 1.41684461355083e-06 11 1.17782679221088 1.21756561993586 1 2.88690878815096 85 363 340 513 301 46 11 153 373 358 46 310 M17527 GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CHAPERONE_COMPLEX.html A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. 18/26 Gene Ontology CC GO:0034663 0.00364828523567309 0.00407625715755012 305 340.181818181818 301 0.000332213573835004 159 2.85382822598142 2.85382822598142 1 3.69628851863739 159 551 262 301 572 297 225 236 441 394 304 311 M17603 GO_NUCLEAR_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MATRIX.html The dense fibrillar network lying on the inner side of the nuclear membrane. 114/158 Gene Ontology CC GO:0016363 8.68991012491083e-06 1.86303977216723e-05 200 281.818181818182 303 7.89994949990058e-07 52 2.13231762003293 2.38048291598183 1 5.50306257868 303 329 197 291 250 384 422 197 52 368 307 312 M17823 GO_DENSE_CORE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENSE_CORE_GRANULE.html Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. 10/17 Gene Ontology CC GO:0031045 4.71425152390689e-06 1.25641290614216e-05 340 294.636363636364 306 4.28569238711953e-07 87 1.76134223287942 -1.64779029029271 -1 4.69896930568744 340 348 188 273 195 306 87 558 359 215 372 313 M17506 GO_DNA_PACKAGING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING_COMPLEX.html A protein complex that plays a role in the process of DNA packaging. 41/109 Gene Ontology CC GO:0044815 0.00103065625089812 0.00121957491195888 485 299.454545454545 307 9.37399463432953e-05 147 1.64513916804592 1.63445317880963 1 2.57514287413392 307 337 241 364 484 169 147 188 482 314 261 314 M17514 GO_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIDE_OF_MEMBRANE.html A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. 395/702 Gene Ontology CC GO:0098552 2.77553688302125e-09 4.74290273245691e-08 535 307.818181818182 307 2.52321535138445e-10 12 2.20046803744044 -2.07941174433409 -1 8.83983663000146 531 155 24 202 12 570 477 571 307 30 507 315 M17810 GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the plasma membrane. 405/687 Gene Ontology CC GO:0098797 3.67569648683095e-20 1.52541404203485e-18 155 258.454545454545 308 3.3415422607554e-21 9 2.40602800303573 2.71133149944364 1 23.6410837305746 470 153 9 151 95 377 578 311 308 15 376 316 M17821 GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERLIN_1_RETROTRANSLOCATION_COMPLEX.html A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. 12/13 Gene Ontology CC GO:0036513 0.00192577626769451 0.0022288366763556 165 288.727272727273 308 0.000175224006381016 53 1.14697662797859 -1.14697662797859 -1 1.60582674457261 163 457 326 240 492 320 308 215 53 412 190 317 M17505 GO_SECRETORY_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_MEMBRANE.html The lipid bilayer surrounding a secretory granule. 81/123 Gene Ontology CC GO:0030667 5.23669658329847e-05 8.02775914220689e-05 260 320.909090909091 309 4.76074657946554e-06 205 1.87360867758728 -1.6386672793086 -1 4.16840588521142 230 296 205 258 366 349 320 519 422 256 309 318 M17690 GO_CORNIFIED_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORNIFIED_ENVELOPE.html A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). 16/67 Gene Ontology CC GO:0001533 5.81035531738264e-05 8.74563844403968e-05 375 284.545454545455 310 5.28228070785716e-06 117 3.03084957095289 -2.55705542423731 -1 6.72829408870338 171 316 117 359 371 310 371 245 486 164 220 319 M17555 GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEOLAR_RIBONUCLEOPROTEIN_COMPLEX.html A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. 18/22 Gene Ontology CC GO:0005732 0.00013975585894209 0.000186945024792137 480 270.363636363636 312 1.27058852524771e-05 9 0.824898423677419 0.855168831670688 1 1.6245087459481 18 312 354 341 477 76 9 233 479 425 250 320 M17568 GO_PRESYNAPTIC_ACTIVE_ZONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_ACTIVE_ZONE.html A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. 21/44 Gene Ontology CC GO:0048786 1.89794606065336e-05 3.30151694981917e-05 455 315 312 1.72542039498552e-06 86 2.68532082317529 2.35995673984236 1 6.58104727164936 452 86 122 105 312 491 538 391 253 204 511 321 M17289 GO_NUCLEAR_REPLICATION_FORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_REPLICATION_FORK.html The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. 41/42 Gene Ontology CC GO:0043596 0.00020187556414769 0.000261137370379243 40 239.181818181818 313 1.83540082687838e-05 39 1.41212304065055 1.54466897303584 1 2.72244595413041 39 338 335 421 432 59 42 116 351 313 185 322 M17483 GO_SPERM_PRINCIPAL_PIECE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PRINCIPAL_PIECE.html The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. 20/29 Gene Ontology CC GO:0097228 2.33708163962347e-06 8.47322892374399e-06 265 297.181818181818 313 2.12462192939271e-07 11 1.4977413677359 1.85052980306158 1 4.12595899887286 284 313 263 369 263 407 490 11 388 342 139 323 M17792 GO_NEURONAL_CELL_BODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_CELL_BODY_MEMBRANE.html The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. 23/44 Gene Ontology CC GO:0032809 1.22083689499381e-05 2.3486961456669e-05 415 302.727272727273 317 1.10985788162373e-06 83 2.72996567383901 2.65183776381228 1 6.91512181951881 421 83 102 271 281 399 430 415 317 199 412 324 M17052 GO_AUTOPHAGOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME.html A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. 78/88 Gene Ontology CC GO:0005776 2.18787979779756e-05 3.72773654698059e-05 105 283 319 1.98900141487653e-06 103 1.16446768122933 -1.10502372035996 -1 2.77616368719591 104 331 413 432 319 103 160 265 412 396 178 325 M17570 GO_EXOCYST http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYST.html A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. 20/21 Gene Ontology CC GO:0000145 8.30650750318038e-05 0.000118868986683443 375 315.181818181818 320 7.55165558848766e-06 69 1.9362302758023 -2.01973774681274 -1 4.12767430246144 271 483 286 320 478 374 267 69 335 374 210 326 M17565 GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_CYTOPLASMIC_SIDE_OF_PLASMA_MEMBRANE.html The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. 105/135 Gene Ontology CC GO:0031234 5.39134405121171e-06 1.3516672816728e-05 360 271.818181818182 321 4.90123387576701e-07 10 1.8452340034847 -1.79730877728918 -1 4.89404947553926 388 10 195 334 209 360 347 321 312 158 356 327 M17418 GO_CELL_TRAILING_EDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_TRAILING_EDGE.html The area of a motile cell opposite to the direction of movement. 14/27 Gene Ontology CC GO:0031254 2.68591147400105e-05 4.39581567998482e-05 325 278.272727272727 322 2.44176751456192e-06 27 2.32606110518446 -1.86364283889096 -1 5.53026678798839 534 102 149 39 332 571 459 324 27 202 322 328 M16978 GO_CLATHRIN_SCULPTED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_SCULPTED_VESICLE.html A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. 17/26 Gene Ontology CC GO:0060198 0.0027846454550177 0.00316610373652697 200 333.545454545455 323 0.000253470579344408 190 1.98169174027265 -1.92850012559081 -1 2.66344647509769 323 420 199 197 501 261 190 408 500 249 421 329 M16998 GO_ER_TO_GOLGI_TRANSPORT_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_TRANSPORT_VESICLE.html A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport. 97/130 Gene Ontology CC GO:0030134 5.75589473712777e-06 1.4051154799459e-05 220 354.636363636364 324 5.23264526947383e-07 180 1.76146973742179 -1.2913874465793 -1 4.65196881563189 454 257 180 219 216 503 431 561 324 231 525 330 M17367 GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. 28/32 Gene Ontology CC GO:0031312 4.7887242947167e-05 7.37997033217613e-05 390 310.363636363636 324 4.35348048519375e-06 103 1.38463638895951 -1.71514708250452 -1 3.08840582492086 387 359 302 317 362 490 369 103 252 324 149 331 M17099 GO_RNA_POLYMERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_COMPLEX.html Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. 124/133 Gene Ontology CC GO:0030880 1.40800007947157e-05 2.63037956968804e-05 235 363.181818181818 325 1.28000826432121e-06 214 1.03358100168477 1.20921820059596 1 2.54205001646254 232 505 488 565 294 234 214 273 334 531 325 332 M17226 GO_U2_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U2. 19/24 Gene Ontology CC GO:0005686 0.00344816608731461 0.00386008573551019 85 317.818181818182 325 0.000313962041190473 83 0.659590039734882 0.659590039734882 1 0.803641196167617 83 373 425 325 511 138 109 234 505 495 298 333 M17657 GO_REPLISOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLISOME.html A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. 28/29 Gene Ontology CC GO:0030894 0.000384980704939818 0.000473885147394141 45 259.363636363636 325 3.50043717905211e-05 33 1.19291907310851 1.23906540999893 1 2.11704876718576 42 361 353 422 458 72 33 149 426 325 212 334 M17389 GO_ENDOCYTIC_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_VESICLE_LUMEN.html The volume enclosed by the membrane of an endocytic vesicle. 21/38 Gene Ontology CC GO:0071682 6.50645698575303e-05 9.57025698410762e-05 380 301.909090909091 326 5.91513583719455e-06 135 3.98139269759781 -4.19938917784562 -1 8.77642404738234 380 413 135 190 382 440 326 353 254 264 184 335 M17643 GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX.html Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. 134/172 Gene Ontology CC GO:0031461 2.46700947918445e-05 4.10696993526122e-05 300 357.636363636364 326 2.24276103988388e-06 189 1.44478067820105 1.69938823705874 1 3.42937742895121 297 503 423 543 326 189 316 322 344 427 244 336 M17802 GO_MICROBODY_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_LUMEN.html The volume enclosed by the membranes of a microbody. 43/53 Gene Ontology CC GO:0031907 3.90445333274387e-05 6.21503393513476e-05 330 239.272727272727 326 3.54956602619119e-06 54 1.42602054544199 -1.48323509123884 -1 3.24188632377147 54 336 330 374 349 93 64 118 405 326 183 337 M17813 GO_CENTRIOLAR_SATELLITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLAR_SATELLITE.html A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. 30/33 Gene Ontology CC GO:0034451 7.37844035760125e-06 1.6649300721774e-05 410 289.454545454545 326 6.70769554890929e-07 25 1.78711774512764 -1.97227314617809 -1 4.64796826265578 326 408 290 274 365 406 444 25 194 348 104 338 M17301 GO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. 413/549 Gene Ontology CC GO:0000785 2.48477233961824e-05 4.11297073879828e-05 195 302.363636363636 328 2.2589094582943e-06 130 1.44365699904994 1.57539371220756 1 3.42614375028522 195 426 453 487 328 146 213 164 369 415 130 339 M17080 GO_CYTOPLASMIC_SIDE_OF_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SIDE_OF_MEMBRANE.html The side of a membrane that faces the cytoplasm. 184/232 Gene Ontology CC GO:0098562 2.05205216902625e-06 8.00162624298156e-06 450 300.181818181818 331 1.86550371189312e-07 115 1.88158866556241 -1.78102351882842 -1 5.22903443252723 449 187 167 331 115 473 421 399 218 138 404 340 M17365 GO_BANDED_COLLAGEN_FIBRIL http://www.broadinstitute.org/gsea/msigdb/cards/GO_BANDED_COLLAGEN_FIBRIL.html A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). 22/23 Gene Ontology CC GO:0098643 0.00342417449689134 0.00384062815191866 30 290.090909090909 332 0.000311774151937584 29 2.91294327077796 2.91294327077796 1 3.81612992697575 29 366 97 332 548 281 361 432 399 132 214 341 M17353 GO_COPI_COATED_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE.html A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. 30/32 Gene Ontology CC GO:0030137 2.27840957816051e-05 3.84744944370605e-05 450 339.545454545455 333 2.07130288603631e-06 199 0.870117581579555 -0.730094929186307 -1 2.04831065515157 242 357 450 264 322 258 199 450 333 474 386 342 M17369 GO_PLATELET_DENSE_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet dense granule. 9/15 Gene Ontology CC GO:0031089 0.0130538302043237 0.014097166075673 335 332.727272727273 333 0.00131311513386423 158 2.59146802890695 -2.33066623351612 -1 2.57673258235763 224 386 531 333 544 334 233 298 158 274 345 343 M17140 GO_GEMINI_OF_COILED_BODIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_GEMINI_OF_COILED_BODIES.html Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). 10/11 Gene Ontology CC GO:0097504 0.00442990044556883 0.0049117789291517 245 361.363636363636 334 0.000403531425525002 188 1.74224345256618 1.74224345256618 1 2.14845988103742 313 460 334 441 530 243 188 244 516 386 320 344 M17554 GO_IMMUNOGLOBULIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_COMPLEX.html A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. 3/117 Gene Ontology CC GO:0019814 2.48132270725909e-05 4.11297073879828e-05 425 349.818181818182 334 2.48135041402521e-06 176 4.15821491061208 3.68660263418394 1 10.0134580581119 423 284 553 312 334 291 236 449 397 176 393 345 M17614 GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_HOLOENZYME.html Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA. 101/110 Gene Ontology CC GO:0016591 3.08317929277292e-05 5.01772316274808e-05 335 347.090909090909 334 2.80292954789713e-06 237 1.04732364478596 1.20807446094226 1 2.41433814184072 257 399 481 408 335 237 242 314 284 527 334 346 M17219 GO_SNARE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNARE_COMPLEX.html A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. 47/55 Gene Ontology CC GO:0031201 4.09971053886747e-05 6.4376535758973e-05 80 258.181818181818 335 3.72707903560271e-06 47 0.971825524188843 -0.928021542929035 -1 2.17654588231809 79 335 442 389 353 47 55 139 470 458 73 347 M17137 GO_MALE_GERM_CELL_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GERM_CELL_NUCLEUS.html The nucleus of a male germ cell, a reproductive cell in males. 18/33 Gene Ontology CC GO:0001673 0.0024526687249069 0.00280511915191123 290 337.272727272727 336 0.000223218850599487 210 1.84523848014495 2.05028514502193 1 2.52841490913344 286 419 234 370 496 241 210 342 460 316 336 348 M17549 GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_COMPLEX.html A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. 17/20 Gene Ontology CC GO:0005942 5.35842503685353e-05 8.19274985897868e-05 345 314.818181818182 336 4.87141413969325e-06 106 1.8657310904919 -2.13143199502489 -1 4.14143483108341 274 343 232 278 367 336 450 451 106 344 282 349 M17683 GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. 49/80 Gene Ontology CC GO:0031463 2.07510815443896e-05 3.55645379861072e-05 340 359.181818181818 336 1.88647975250945e-06 142 1.88177233972283 2.13635539356288 1 4.55503964738308 336 522 312 560 317 300 400 289 378 395 142 350 M17249 GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_1_COMPLEX.html A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. 10/11 Gene Ontology CC GO:0000164 0.0021055935288234 0.00242247493118098 275 356.909090909091 337 0.000191601042860073 60 1.2456895265536 -1.2456895265536 -1 1.72573030233804 275 564 337 495 557 223 60 207 510 440 258 351 M17501 GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_CYCLE_ENZYME_COMPLEX.html Any of the heteromeric enzymes that act in the TCA cycle. 10/13 Gene Ontology CC GO:0045239 2.52266257706349e-05 4.16382658316445e-05 215 303.909090909091 337 2.29335591273805e-06 25 0.801667857708639 0.801667857708639 1 1.86588587355927 213 459 356 514 329 140 25 337 471 441 58 352 M17290 GO_INVADOPODIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_INVADOPODIUM.html A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate. 14/17 Gene Ontology CC GO:0071437 9.12349991142656e-05 0.000127728998759972 355 327.818181818182 338 8.29443480825412e-06 161 1.83154561609323 1.94032166045025 1 3.86869796083521 354 345 212 296 398 451 467 161 338 271 313 353 M17360 GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTRIMERIC_G_PROTEIN_COMPLEX.html Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. 30/41 Gene Ontology CC GO:0005834 0.000109378237109533 0.000149526484142679 475 342.454545454545 338 9.94397049886406e-06 184 1.72870401842292 -1.47170431986595 -1 3.58168868126331 475 269 249 342 409 430 184 338 322 318 431 354 M17382 GO_SIN3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_COMPLEX.html A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. 17/19 Gene Ontology CC GO:0016580 0.000466299746256579 0.000569159984401413 325 353.545454545455 339 4.23998736264749e-05 239 1.00273755159922 0.71019224191628 1 1.72310079956835 324 452 355 324 464 272 239 276 425 419 339 355 M17479 GO_CHD_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHD_TYPE_COMPLEX.html A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. 20/23 Gene Ontology CC GO:0090545 0.000137860236367166 0.000184981056187814 375 291.090909090909 339 1.25335341785139e-05 98 1.07336347660446 0.99190863551272 1 2.13977604247229 268 368 350 375 418 213 98 168 339 373 232 356 M17538 GO_HETEROCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN.html A compact and highly condensed form of chromatin. 76/86 Gene Ontology CC GO:0000792 3.27793394876261e-05 5.30495717056011e-05 210 328.090909090909 339 2.97998435455738e-06 129 1.26476414114278 1.28224398431787 1 2.91468647118406 206 432 389 492 339 240 205 294 467 416 129 357 M17783 GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHATASE_TYPE_2A_COMPLEX.html A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. 20/24 Gene Ontology CC GO:0000159 0.000107603556240748 0.000147447325886497 410 302.272727272727 340 9.78261996065551e-06 12 1.52556303191679 -0.732966730184343 -1 3.15687263643147 426 369 278 340 408 389 263 129 12 406 305 358 M17119 GO_SECRETORY_VESICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_VESICLE.html A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. 434/739 Gene Ontology CC GO:0099503 2.19602945342875e-07 2.4536406008502e-06 395 293.181818181818 341 1.99639061148672e-08 38 2.13585975089777 -1.90519860830968 -1 6.55276570842633 395 252 38 330 116 429 359 531 341 42 392 359 M17689 GO_DENDRITE_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_CYTOPLASM.html All of the contents of a dendrite, excluding the surrounding plasma membrane. 19/26 Gene Ontology CC GO:0032839 3.14259887742261e-05 5.10013951894563e-05 505 353.545454545455 341 2.85694888081895e-06 144 1.89214593509909 -1.54007061740384 -1 4.41666539954224 504 341 215 144 336 546 508 395 170 239 491 360 M17701 GO_PERICENTRIOLAR_MATERIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICENTRIOLAR_MATERIAL.html A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. 23/25 Gene Ontology CC GO:0000242 1.96874693004912e-06 7.94334698860095e-06 275 333.545454545455 341 1.78977153804851e-07 109 1.58442403648358 1.38773084535371 1 4.39380097548962 494 305 275 275 109 423 375 414 123 341 535 361 M17081 GO_PLATELET_ALPHA_GRANULE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_MEMBRANE.html The lipid bilayer surrounding the platelet alpha granule. 15/16 Gene Ontology CC GO:0031092 0.0025501016989059 0.00290511585698888 265 341.727272727273 343 0.00023209658383989 169 2.28025979042833 2.76668040607195 1 3.12348712238877 264 374 169 343 499 295 365 279 485 317 369 362 M17822 GO_PLATELET_DENSE_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DENSE_GRANULE.html Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. 22/31 Gene Ontology CC GO:0042827 3.5350554400508e-05 5.68938285504021e-05 385 334.363636363636 343 3.21373840375731e-06 192 2.04238915221735 -1.96173808395114 -1 4.71983057923778 295 411 192 314 343 382 259 381 480 247 374 363 M17174 GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_PEROXISOMAL_MEMBRANE.html The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 14/16 Gene Ontology CC GO:0031231 0.00959919710206357 0.0104050998438413 305 338 344 0.000876485332288434 195 1.84518244392838 -0.829636972794348 -1 1.94712629880205 304 380 247 344 527 367 195 302 245 390 417 364 M17354 GO_NUCLEAR_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EUCHROMATIN.html The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin. 33/47 Gene Ontology CC GO:0005719 0.000230543693678684 0.000295686282621006 460 336.090909090909 345 2.09607142267266e-05 22 1.356197790207 1.33770121584312 1 2.57108081250775 459 358 282 345 485 327 317 259 476 367 22 365 M17697 GO_MICROBODY_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_PART.html Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). 98/112 Gene Ontology CC GO:0044438 3.61105799732558e-05 5.79564833272421e-05 395 288.454545454545 345 3.28283388202952e-06 74 1.42014442601837 -1.27341249887249 -1 3.25205091974656 74 395 391 468 345 141 88 229 366 423 253 366 M17710 GO_MICROTUBULE_ORGANIZING_CENTER_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_PART.html Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow. 163/194 Gene Ontology CC GO:0044450 7.5114364821935e-06 1.67208605216644e-05 255 315.818181818182 345 6.82860193503033e-07 97 1.52618128139825 1.49969731659953 1 3.95648631280992 255 499 417 429 238 97 135 345 381 432 246 367 M17804 GO_METHYLOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLOSOME.html A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. 12/17 Gene Ontology CC GO:0034709 9.93223517481216e-05 0.000137529566747092 30 284.181818181818 345 9.02971237185882e-06 7 0.743748151915784 0.743748151915784 1 1.51197063885537 30 346 345 377 513 99 7 219 487 411 292 368 M17144 GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ENDOPLASMIC_RETICULUM_MEMBRANE.html The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 142/180 Gene Ontology CC GO:0031227 4.42078738477338e-06 1.21728790073618e-05 310 349.545454545455 346 4.01890569831303e-07 190 1.43783331092233 -1.36807140399083 -1 3.83266569551678 309 326 384 397 190 303 401 468 346 422 299 369 M17194 GO_VESICLE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LUMEN.html The volume enclosed by the membrane or protein that forms a vesicle. 89/213 Gene Ontology CC GO:0031983 1.16069496952589e-06 6.94007103560441e-06 435 301.454545454545 347 1.05517780172346e-07 41 3.07497679164351 -3.16556301060692 -1 8.69960734982532 434 398 52 356 41 507 404 325 347 110 342 370 M16983 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. 10/18 Gene Ontology CC GO:0034362 0.000360438653937879 0.000450354533199802 540 358.727272727273 349 3.2772520020382e-05 79 2.30231206323711 -1.7366715053618 -1 4.18576502368045 537 349 183 193 451 548 575 205 79 292 534 371 M17051 GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex found in the cytoplasm. 14/16 Gene Ontology CC GO:0000153 7.31268123391296e-06 1.6596358581654e-05 295 353.909090909091 349 6.64791412816703e-07 117 0.761080993174179 -0.800890464600393 -1 1.93573673463673 292 490 403 496 234 339 117 349 504 428 241 372 M17297 GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX.html A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. 74/83 Gene Ontology CC GO:0070603 1.32591229215352e-05 2.49305838751196e-05 220 340 349 1.20538207575213e-06 220 1.20749707178455 1.12987710789083 1 2.99832409267421 220 433 422 426 290 236 268 374 255 467 349 373 M17845 GO_COLLAGEN_TRIMER http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_TRIMER.html A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. 58/89 Gene Ontology CC GO:0005581 1.9166750287591e-08 2.52548442443469e-07 75 293.454545454545 350 1.74243185950679e-09 32 2.96922307947708 3.22614155282262 1 10.7618585753752 73 262 32 461 509 350 442 370 365 61 303 374 M17103 GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX.html A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. 99/124 Gene Ontology CC GO:0090575 1.78243885350414e-05 3.15096262637403e-05 365 370.090909090909 351 1.62041208634386e-06 286 1.25835984454621 1.42018451631568 1 3.05705414029339 363 396 452 472 308 318 351 303 286 493 329 375 M17107 GO_SMN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_COMPLEX.html A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. 12/13 Gene Ontology CC GO:0032797 0.000671002712006349 0.000807148189804739 280 349.181818181818 351 6.10188596447353e-05 203 1.36683431104439 1.36683431104439 1 2.26202810457543 276 458 351 440 472 210 203 231 513 407 280 376 M17124 GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription. 25/28 Gene Ontology CC GO:0090568 4.02472652390248e-05 6.35425573474822e-05 305 357.545454545455 352 3.65890923180588e-06 276 1.02508608873802 1.00460704574284 1 2.30326932917278 302 445 377 430 352 276 305 288 459 393 306 377 M17413 GO_SIN3_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIN3_TYPE_COMPLEX.html Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. 20/22 Gene Ontology CC GO:0070822 0.000132753330509666 0.000178955185675443 375 346.545454545455 352 1.20692128949168e-05 227 1.07775817264121 0.754040678977955 1 2.15742955619642 339 371 352 322 416 267 227 341 395 372 410 378 M17047 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_OUTER_MEMBRANE.html The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 21/28 Gene Ontology CC GO:0031306 0.00193361548515374 0.00223346043116168 310 376.454545454545 353 0.000175937915011369 246 0.719583261290183 0.800128530399145 1 0.978357235127814 308 448 428 353 493 254 246 334 488 502 287 379 M17698 GO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_APPARATUS.html A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. 1482/1929 Gene Ontology CC GO:0005794 9.48745356907891e-07 6.94007103560441e-06 420 307.363636363636 353 9.48745761961121e-08 26 1.86666734485075 -1.63251800999441 -1 5.25079853848632 419 120 569 302 26 368 353 496 205 123 400 380 M17237 GO_PCG_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PCG_PROTEIN_COMPLEX.html A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. 50/52 Gene Ontology CC GO:0031519 4.15802884617556e-05 6.51163007985984e-05 230 322.454545454545 354 3.78009766867768e-06 121 1.0885537739348 1.26198889560061 1 2.44425080251432 229 472 437 446 354 202 228 184 454 420 121 381 M17031 GO_HOLO_TFIIH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOLO_TFIIH_COMPLEX.html A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. 12/12 Gene Ontology CC GO:0005675 0.000536635771088021 0.000652270675736695 315 362.090909090909 355 4.87969740795878e-05 208 0.8303115564617 0.884167100421434 1 1.38634885109382 355 383 369 348 466 311 208 315 483 456 289 382 M17510 GO_POLE_PLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLE_PLASM.html Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. 6/18 Gene Ontology CC GO:0045495 8.91630021762166e-05 0.000125737146272771 430 311.272727272727 355 8.91665798966825e-06 103 1.70492108361827 1.65526001575433 1 3.60234126538832 430 115 549 233 401 457 355 147 103 228 406 383 M17015 GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TUBULAR_NETWORK.html A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. 15/15 Gene Ontology CC GO:0071782 6.45221775330357e-06 1.52387744498755e-05 260 363.363636363636 356 5.86566970601352e-07 225 1.14639682800527 -0.929446323763992 -1 2.97830519522463 507 236 306 257 225 493 460 472 257 356 428 384 M17076 GO_MICROBODY_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROBODY_MEMBRANE.html The lipid bilayer surrounding a microbody. 64/69 Gene Ontology CC GO:0031903 4.23461505959475e-05 6.61374018716276e-05 175 306.818181818182 356 3.84972415520159e-06 73 1.38801463815292 -1.1048413064592 -1 3.13269072752879 172 435 367 516 356 176 73 199 362 453 266 385 M17075 GO_ACROSOMAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOMAL_MEMBRANE.html The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. 15/29 Gene Ontology CC GO:0002080 0.00295593946213224 0.00334775989765854 335 371.272727272727 357 0.000269083506861655 276 1.6723020932195 -1.54866386732028 -1 2.21315905093869 332 421 276 349 503 343 297 400 429 357 377 386 M17147 GO_SEX_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_CHROMOSOME.html A chromosome involved in sex determination. 35/46 Gene Ontology CC GO:0000803 3.72415187087128e-05 5.96069486770307e-05 410 352.727272727273 357 3.38564992242785e-06 115 1.56730378191773 1.38880490401745 1 3.58645420707351 410 442 277 423 346 434 407 115 357 337 332 387 M17045 GO_SECRETORY_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE.html A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. 326/584 Gene Ontology CC GO:0030141 2.88346181025401e-06 9.28571818473764e-06 400 318.909090909091 358 2.62133235410169e-07 50 2.20322995572032 -1.95848489414252 -1 6.05728122051191 400 351 50 392 152 437 338 541 358 67 422 388 M17546 GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_II_CORE_COMPLEX.html RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 20/22 Gene Ontology CC GO:0005665 0.00498255777608176 0.00550354765761123 360 390.272727272727 359 0.000453988925273307 301 0.745813632212439 0.860071515062817 1 0.855209778475802 301 372 404 323 517 335 349 357 503 473 359 389 M17611 GO_EUCHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUCHROMATIN.html A dispersed and relatively uncompacted form of chromatin. 41/56 Gene Ontology CC GO:0000791 2.57491953094646e-05 4.2260684957059e-05 360 309.181818181818 359 2.34086333523741e-06 1 1.36917157829111 1.36215859165047 1 3.23646813237813 360 440 311 399 470 244 226 114 477 359 1 390 M17310 GO_COMPLEX_OF_COLLAGEN_TRIMERS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEX_OF_COLLAGEN_TRIMERS.html A complex of collagen trimers such as a fibril or collagen network. 28/30 Gene Ontology CC GO:0098644 0.000313717576879015 0.000396238939492843 50 309.727272727273 360 2.85238474175422e-05 50 3.05648524688219 3.11076892595767 1 5.67619111669128 50 360 79 393 538 326 416 470 379 106 290 391 M17100 GO_MRNA_CLEAVAGE_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE_FACTOR_COMPLEX.html Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. 19/20 Gene Ontology CC GO:0005849 0.00858066913742917 0.00931844629690906 235 348.272727272727 361 0.000783120022754351 152 1.45958831997318 -1.70629329811129 -1 1.56279718683329 234 488 385 470 526 230 152 296 361 437 252 392 M17806 GO_GOLGI_CISTERNA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_CISTERNA_MEMBRANE.html The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. 72/86 Gene Ontology CC GO:0032580 6.11681126425792e-06 1.47484735264245e-05 245 391.363636363636 361 5.56075297392278e-07 219 1.76688150468335 2.19433133125669 1 4.64593403902362 523 298 242 361 219 529 580 507 241 307 498 393 M17556 GO_SMN_SM_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMN_SM_PROTEIN_COMPLEX.html A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. 16/21 Gene Ontology CC GO:0034719 0.000611994318129997 0.000737694395920184 55 302.090909090909 362 5.5651329870255e-05 39 0.91435386634957 0.91435386634957 1 1.5074383099985 55 451 362 435 471 86 39 226 511 404 283 394 M17671 GO_KERATIN_FILAMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATIN_FILAMENT.html A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. 27/107 Gene Ontology CC GO:0045095 1.10950077540622e-08 1.53480940597861e-07 565 302.363636363636 363 1.00863707363785e-09 30 4.13909138514803 -2.56175356134551 -1 15.5277310393988 563 71 30 150 363 424 521 476 141 47 540 395 M16982 GO_RNA_CAP_BINDING_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAP_BINDING_COMPLEX.html Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. 15/20 Gene Ontology CC GO:0034518 0.000602707238518879 0.000728010198709914 270 346.818181818182 364 5.4806583476924e-05 52 1.25669343078665 1.4045686659799 1 2.10469828452098 270 550 364 518 512 221 52 140 436 475 277 396 M16989 GO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME.html A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. 863/1183 Gene Ontology CC GO:0005694 4.55875689860046e-05 7.04482051424787e-05 425 273.090909090909 364 4.55885042149074e-06 51 1.45307238124865 1.56384676688887 1 3.26109090582904 58 425 510 425 364 51 103 111 376 457 124 397 M17522 GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK.html The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. 957/1316 Gene Ontology CC GO:0042175 1.03914900081371e-06 6.94007103560441e-06 385 334.818181818182 365 1.03914948673782e-07 38 1.78458347141543 -1.62273729625304 -1 5.01651121521497 347 285 551 391 38 365 385 420 233 286 382 398 M17551 GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_I_COMPLEX.html RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 13/15 Gene Ontology CC GO:0005736 0.00174957627747534 0.00203300763442635 510 348.363636363636 365 0.000159179018180722 48 0.833925846219438 0.927283977492688 1 1.16491782540909 227 560 365 448 510 211 48 191 506 464 302 399 M17561 GO_ANCHORING_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANCHORING_JUNCTION.html A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. 638/772 Gene Ontology CC GO:0070161 9.00772198330049e-07 6.94007103560441e-06 435 312.818181818182 365 9.00772563456006e-08 20 2.02078996240372 2.37634989001302 1 5.69070194473227 433 248 554 180 20 472 548 406 152 63 365 400 M17649 GO_CHROMATOID_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATOID_BODY.html A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). 8/15 Gene Ontology CC GO:0033391 0.000379304867270895 0.000468885378477425 370 392.727272727273 367 3.79369625310078e-05 30 1.87486658538155 -2.01975851231926 -1 3.37615411955883 571 350 563 251 460 543 514 367 30 304 367 401 M17704 GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_COMPLEX.html Any complex formed of proteins that act in nucleotide-excision repair. 15/16 Gene Ontology CC GO:0000109 0.000282816883737505 0.000358769889632076 180 307.090909090909 368 2.57139315706827e-05 30 1.42380149003714 1.42380149003714 1 2.63692678164985 179 492 368 383 560 152 30 110 473 439 192 402 M17220 GO_DNA_REPLICATION_FACTOR_A_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_FACTOR_A_COMPLEX.html A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. 14/14 Gene Ontology CC GO:0005662 0.000181551954220622 0.000237012964993907 430 308.363636363636 370 1.65060852977707e-05 38 0.937671854523373 0.937671854523373 1 1.80367470456159 121 553 370 445 427 100 38 190 501 430 217 403 M17634 GO_IKAPPAB_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_IKAPPAB_KINASE_COMPLEX.html A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 10/12 Gene Ontology CC GO:0008385 0.000170021574230136 0.000223996677160338 375 323.909090909091 370 1.5457701395456e-05 111 1.01098745079403 -1.03376049202156 -1 1.96445411989196 370 111 309 372 424 419 269 377 375 336 201 404 M17130 GO_CHROMOSOMAL_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOMAL_REGION.html Any subdivision of a chromosome along its length. 337/530 Gene Ontology CC GO:0098687 7.17749724784977e-05 0.000104253147525018 385 249.181818181818 371 6.5252103857307e-06 11 1.5078909903597 1.63483823892136 1 3.24501324777073 11 427 474 380 384 36 40 100 371 382 136 405 M17210 GO_OUTER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the outer mitochondrial membrane. 11/12 Gene Ontology CC GO:0098799 0.0162964420880211 0.0175013546268766 200 355 371 0.00149258404162391 99 0.691392387057801 0.592317884192076 1 0.59497752890115 199 424 360 381 533 229 99 362 497 450 371 406 M17281 GO_PROTEIN_DNA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX.html A macromolecular complex containing both protein and DNA molecules. 110/191 Gene Ontology CC GO:0032993 0.000103795806010276 0.000142565870666596 200 311.909090909091 371 9.4364275827942e-06 108 1.43078433893927 1.51280176665402 1 2.96752896002514 197 469 371 538 406 143 206 108 458 397 138 407 M17054 GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_H4_HISTONE_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of H4 histone acetyltransferase activity. 23/27 Gene Ontology CC GO:1902562 6.30670760942567e-05 9.3194536929535e-05 455 320.636363636364 372 5.73353491830946e-06 62 1.60322242380331 2.27419047411098 1 3.49824277059207 455 447 245 321 438 427 372 62 206 401 153 408 M17245 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX.html A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. 42/53 Gene Ontology CC GO:0016469 1.37143593927859e-05 2.57033638942212e-05 375 345.727272727273 372 1.24676771691834e-06 156 1.21980025055555 -1.49837570698255 -1 3.02071220069533 156 525 372 537 292 375 426 195 174 472 279 409 M17604 GO_AXOLEMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXOLEMMA.html The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. 22/34 Gene Ontology CC GO:0030673 6.02422846714433e-05 8.97455574207912e-05 375 336 372 5.47672130368473e-06 49 2.76039710986659 2.66274605437268 1 6.10388612245007 488 306 136 49 375 510 519 372 142 221 578 410 M17134 GO_NUCLEAR_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INCLUSION_BODY.html An intranuclear focus at which aggregated proteins have been sequestered. 14/14 Gene Ontology CC GO:0042405 8.7630981597924e-05 0.000124095865061177 230 356.090909090909 375 7.96677021209203e-06 72 1.52957453028243 1.52957453028243 1 3.22874743528292 228 562 375 449 580 283 202 72 474 429 263 411 M17338 GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FACTOR_TFTC_COMPLEX.html A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. 15/19 Gene Ontology CC GO:0033276 1.00078751740586e-05 2.03306834829652e-05 375 381.727272727273 376 9.09810972774062e-07 194 0.783279391213068 0.837303291974707 1 1.95624760407739 442 376 373 400 266 352 194 547 400 476 373 412 M17457 GO_XY_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XY_BODY.html A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. 21/32 Gene Ontology CC GO:0001741 0.000202257860018347 0.000261137370379243 380 379.636363636364 377 1.83887688243123e-05 228 1.61896804406563 -2.06853729436821 -1 3.13252140820474 463 310 252 376 433 524 470 228 377 287 456 413 M17001 GO_CENTRIOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE.html A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. 111/137 Gene Ontology CC GO:0005814 6.30293359881424e-05 9.3194536929535e-05 470 290.272727272727 379 5.73010380291152e-06 52 1.40888866142296 1.50465199339244 1 3.06485660402548 161 470 449 499 379 52 66 113 466 424 114 414 M17579 GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXY_TERMINAL_DOMAIN_PROTEIN_KINASE_COMPLEX.html A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. 23/27 Gene Ontology CC GO:0032806 0.00216549393889452 0.00248646636066743 280 358.636363636364 379 0.000197057128177707 268 1.08072635136002 -1.2924872727531 -1 1.48021252132128 402 308 383 280 494 379 280 275 268 485 391 415 M17464 GO_BETA_CATENIN_DESTRUCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX.html A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. 17/18 Gene Ontology CC GO:0030877 0.000182586656222365 0.000237321805962404 490 372.909090909091 380 1.66001646880301e-05 75 1.58996795181464 1.48461216818274 1 3.1115639755089 489 315 239 255 429 532 553 264 75 380 571 416 M17653 GO_TOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_COMPLEX.html A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. 15/17 Gene Ontology CC GO:0038201 0.000382882399149431 0.000472302916997493 440 387.818181818182 380 3.4813550115267e-05 239 0.934946652824234 -1.070304623192 -1 1.64330358002798 239 455 357 439 457 305 380 328 533 438 335 417 M17202 GO_ORGANELLE_MEMBRANE_CONTACT_SITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_CONTACT_SITE.html A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. 12/13 Gene Ontology CC GO:0044232 0.000210342330700686 0.000270973157731926 540 365.636363636364 381 1.91238585686253e-05 125 1.27021948620406 0.692886294276303 1 2.42983345390186 538 381 298 299 434 537 501 125 250 408 251 418 M17022 GO_U1_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U1_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U1. 17/22 Gene Ontology CC GO:0005685 0.00748342582395906 0.00815138956312727 385 370.545454545455 382 0.000682636637387354 161 0.738599691596321 0.759410019369275 1 0.776478353672463 235 375 382 382 524 248 161 437 528 454 350 419 M17307 GO_CELL_JUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION.html A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. 1230/1673 Gene Ontology CC GO:0030054 9.44553271760401e-19 3.42990906807996e-17 410 288.545454545455 382 9.44553271760402e-20 10 2.21439504430665 2.50139660602138 1 20.0956417125922 409 123 528 179 45 391 570 382 130 10 407 420 M17191 GO_PROTEIN_KINASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_COMPLEX.html A protein complex which is capable of protein kinase activity. 95/131 Gene Ontology CC GO:1902911 6.26839633531072e-05 9.31442012996299e-05 410 384 383 5.69870449639847e-06 246 1.30511298906428 -1.09193866830194 -1 2.8335946026823 406 293 402 318 378 383 321 538 246 466 473 421 M17679 GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_AUTOPHAGOSOMAL_STRUCTURE_MEMBRANE.html A cellular membrane associated with the pre-autophagosomal structure. 18/18 Gene Ontology CC GO:0034045 1.41948191183146e-05 2.64333009863486e-05 350 366.090909090909 384 1.29044642789264e-06 162 0.781555918519316 -0.873403927477894 -1 1.90247671351283 349 416 409 442 295 328 162 384 465 491 286 422 M17663 GO_INTERCELLULAR_BRIDGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERCELLULAR_BRIDGE.html A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. 49/52 Gene Ontology CC GO:0045171 5.50262439647917e-07 4.99535120992875e-06 480 378.454545454545 385 5.00238706617469e-08 4 1.44773491845231 1.4800498159628 1 4.16944800646535 476 520 346 542 4 414 304 369 452 351 385 423 M17171 GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the cytoplasm. 17/18 Gene Ontology CC GO:0000177 0.000349993362451335 0.000438245999103935 235 376.636363636364 386 3.18226413238092e-05 113 0.73598448106433 0.801452127900089 1 1.29042209011046 233 539 386 544 450 251 113 267 512 484 364 424 M17178 GO_PRECATALYTIC_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRECATALYTIC_SPLICEOSOME.html A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. 22/27 Gene Ontology CC GO:0071011 0.00504808997702415 0.00556535156859778 90 340.181818181818 387 0.000459973691173984 71 0.666719738327285 0.666719738327285 1 0.754546284257611 90 415 439 387 518 164 71 293 521 504 340 425 M17329 GO_ARP2_3_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_PROTEIN_COMPLEX.html A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. 10/11 Gene Ontology CC GO:0005885 9.17615619271175e-05 0.000128157373749171 340 385.181818181818 387 8.34230813700927e-06 338 1.00592871901813 -0.978283317339419 -1 2.08920674567997 405 385 338 347 399 439 434 366 340 387 397 426 M17703 GO_TELOMERE_CAP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAP_COMPLEX.html A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. 14/14 Gene Ontology CC GO:0000782 0.00145707150191865 0.00169991675223842 240 373.272727272727 387 0.000132548856703634 182 0.819450589700398 0.787020203008148 1 1.17859262129933 238 557 387 471 506 266 272 182 498 470 259 427 M17380 GO_DNA_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR_COMPLEX.html A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 40/43 Gene Ontology CC GO:1990391 0.00130279346985454 0.00152913738582927 495 324.090909090909 388 0.000118505963345567 112 1.09052303625715 1.11217166274407 1 1.62172491695375 146 476 463 388 500 112 119 177 493 494 197 428 M17469 GO_MISMATCH_REPAIR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR_COMPLEX.html Any complex formed of proteins that act in mismatch repair. 10/12 Gene Ontology CC GO:0032300 0.0152970571828841 0.0164890356646673 350 400.181818181818 388 0.00140040616858689 255 0.903614472896881 0.793266271214523 1 0.814215507045196 396 497 349 401 531 351 255 346 508 388 380 429 M16997 GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases found in the nucleus. 15/15 Gene Ontology CC GO:0000176 0.000196695845887811 0.000255089925135755 135 353 390 1.78830394649754e-05 32 0.695864046823479 0.678475283752477 1 1.30636220209717 132 491 390 519 431 166 32 310 525 541 346 430 M17028 GO_NUCLEOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOID.html The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. 64/68 Gene Ontology CC GO:0009295 0.00116804049422015 0.0013765345378132 220 359.727272727273 390 0.000106241918216474 179 0.885183226987182 1.00711732923249 1 1.32420301589701 218 471 476 390 486 222 179 218 532 516 249 431 M17626 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT.html A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. 141/169 Gene Ontology CC GO:0005793 4.79322770702433e-06 1.26584786262779e-05 565 403.181818181818 391 4.35748922750225e-07 197 1.83664200286851 2.01310097521293 1 4.89985199168571 562 391 243 338 197 576 518 485 293 320 512 432 M17112 GO_BLOC_1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_1_COMPLEX.html A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. 15/16 Gene Ontology CC GO:0031083 0.000513233003227345 0.000625132861373349 390 436.909090909091 392 4.66684339370958e-05 271 0.730732317662372 -0.707340599289334 -1 1.21829638424506 389 555 392 547 465 390 328 271 566 549 354 433 M17320 GO_PLATELET_ALPHA_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE_LUMEN.html The volume enclosed by the membrane of the platelet alpha granule. 51/92 Gene Ontology CC GO:0031093 6.84215714754968e-06 1.59011732109054e-05 270 319 393 6.22016220658163e-07 70 3.07191298272654 3.0853920974609 1 8.07886988319819 269 405 70 414 230 308 398 458 393 119 445 434 M17847 GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIN_DEPENDENT_PROTEIN_KINASE_HOLOENZYME_COMPLEX.html Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. 32/39 Gene Ontology CC GO:0000307 0.00139692433992237 0.00163302422835996 430 357.454545454545 393 0.000127073829830723 97 1.50236037967685 -1.09149906376994 -1 2.23956827319696 429 301 295 236 489 402 345 393 97 417 528 435 M17110 GO_SCF_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). 35/37 Gene Ontology CC GO:0019005 7.3020630101302e-05 0.000105534791265812 465 407.636363636364 395 6.63845944144893e-06 289 1.28257204065963 1.50262988463817 1 2.74483209250934 464 339 328 486 387 381 395 497 409 289 509 436 M17417 GO_EXTERNAL_ENCAPSULATING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTERNAL_ENCAPSULATING_STRUCTURE.html A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space. 8/13 Gene Ontology CC GO:0030312 2.31948798159773e-05 3.89486276678695e-05 555 393.909090909091 395 2.31951219206362e-06 260 1.58723114683914 -1.00004847304575 -1 3.7953310513999 551 282 536 395 330 435 260 428 270 303 543 437 M17525 GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONALLY_ACTIVE_CHROMATIN.html The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. 23/28 Gene Ontology CC GO:0035327 5.90408261935132e-05 8.86375194274707e-05 365 405.272727272727 397 5.36749188329997e-06 254 1.66064555494233 -1.84357498889705 -1 3.64630827565239 417 365 254 365 372 575 558 397 443 309 403 438 M17564 GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_GOLGI_INTERMEDIATE_COMPARTMENT_MEMBRANE.html The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. 89/112 Gene Ontology CC GO:0033116 4.01814553395486e-05 6.35425573474822e-05 555 408.545454545455 397 3.65292629494403e-06 163 2.0974921691533 2.44465874470783 1 4.79354599854617 536 397 163 335 350 567 547 553 237 254 555 439 M17207 GO_CCR4_NOT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CCR4_NOT_COMPLEX.html The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins. 18/18 Gene Ontology CC GO:0030014 0.000579976722172244 0.000703479072196396 465 417 398 5.27390614040008e-05 314 0.883918054398819 -0.857850110719631 -1 1.46478063592801 462 314 358 398 468 394 335 526 464 353 515 440 M17065 GO_PLATELET_ALPHA_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ALPHA_GRANULE.html A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). 71/117 Gene Ontology CC GO:0031091 1.05966199403814e-05 2.1219245197643e-05 465 350.454545454545 401 9.63333725535138e-07 81 2.63547799173551 2.9219896583529 1 6.73741291934251 316 401 81 463 269 359 464 422 435 173 472 441 M17585 GO_GOLGI_TRANSPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TRANSPORT_COMPLEX.html A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). 12/12 Gene Ontology CC GO:0017119 0.000942476440982484 0.00111979307200577 170 338.727272727273 401 8.57164035169675e-05 141 0.575096971486394 -0.575096971486394 -1 0.861834079808948 169 495 401 406 481 157 141 185 550 569 172 442 M17259 GO_PML_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PML_BODY.html A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. 109/135 Gene Ontology CC GO:0016605 8.40025844071677e-05 0.000119915237200404 450 368.363636363636 402 7.63689018624749e-06 109 1.90151807231711 -1.70330438879637 -1 4.04828775253998 450 330 287 297 392 462 411 487 109 402 425 443 M17308 GO_NUCLEAR_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMATIN.html The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. 275/368 Gene Ontology CC GO:0000790 9.94189639135608e-05 0.000137529566747092 315 352.818181818182 402 9.03849608948761e-06 195 1.34363653202942 1.49607550175606 1 2.79369380467151 312 428 456 444 402 195 274 262 414 483 211 444 M17440 GO_SMOOTH_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_ENDOPLASMIC_RETICULUM.html The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. 43/64 Gene Ontology CC GO:0005790 0.000333902553135498 0.000419000828016683 445 398.454545454545 402 3.03593855995377e-05 300 1.50093101578585 -1.25529027415698 -1 2.72797925174313 443 439 339 300 448 460 389 319 401 443 402 445 M17269 GO_NUCLEAR_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME.html A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. 501/765 Gene Ontology CC GO:0000228 9.10866894474796e-05 0.000127728998759972 85 299.818181818182 403 9.10904232161235e-06 62 1.38890228812966 1.52892444257978 1 2.91508172470915 82 463 526 447 403 62 112 144 416 479 164 446 M17795 GO_HISTONE_DEACETYLASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEACETYLASE_COMPLEX.html A protein complex that possesses histone deacetylase activity. 63/70 Gene Ontology CC GO:0000118 6.59073776972242e-05 9.64538701312022e-05 435 368.818181818182 403 5.99175929332727e-06 192 1.11306708662147 0.972902640031697 1 2.39594698935073 320 403 435 436 383 228 192 424 446 433 357 447 M17153 GO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAJAL_BODY.html A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. 57/64 Gene Ontology CC GO:0015030 4.55912652901411e-05 7.04482051424787e-05 405 411.909090909091 404 4.14474637446644e-06 360 1.20795656392031 1.06533883553379 1 2.69797428826133 404 404 400 379 360 444 403 403 408 455 471 448 M17724 GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX.html Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. 47/50 Gene Ontology CC GO:0008023 0.000102950592063312 0.000141740033148778 325 405.181818181818 405 9.35958272967421e-06 283 0.932023797482352 -1.06414649887895 -1 1.90748727886376 325 438 466 454 405 358 283 379 478 501 370 449 M17532 GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX.html A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. 124/154 Gene Ontology CC GO:0044798 1.78428004144072e-05 3.15096262637403e-05 400 406.090909090909 406 1.62208592069576e-06 309 1.24853815515928 1.44981687685672 1 3.03259140693475 397 429 471 452 309 362 406 440 349 492 360 450 M17800 GO_SITE_OF_DOUBLE_STRAND_BREAK http://www.broadinstitute.org/gsea/msigdb/cards/GO_SITE_OF_DOUBLE_STRAND_BREAK.html A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. 35/46 Gene Ontology CC GO:0035861 0.000417940502842995 0.000512285721839199 380 385.363636363636 407 3.80018110326187e-05 232 1.14221570275236 1.27924003883615 1 2.00240279915719 377 407 378 433 462 239 232 482 455 413 361 451 M17218 GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_SMALL_RIBOSOMAL_SUBUNIT.html The small subunit of a ribosome located in the cytosol. 47/76 Gene Ontology CC GO:0022627 0.0265817198525761 0.0281824438582969 390 402.909090909091 409 0.00244622148204819 127 0.600447392665401 -0.470237609010699 -1 0.437830601569853 177 531 482 409 550 277 127 389 579 524 387 452 M17797 GO_U12_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U12_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. 29/35 Gene Ontology CC GO:0005689 0.000367997699891006 0.000458812582911319 450 325.363636363636 409 3.34599336276476e-05 79 0.72211540408388 0.726491086411006 1 1.25669388650644 101 409 446 450 453 129 79 253 507 488 264 453 M16988 GO_CYTOCHROME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX.html A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 18/29 Gene Ontology CC GO:0070069 0.0429709463356498 0.0449839996775001 265 402 410 0.00398490537081384 263 1.93054189804352 2.46154100963654 1 1.36162239604316 263 541 284 469 581 410 340 343 305 459 427 454 M17146 GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FANCONI_ANAEMIA_NUCLEAR_COMPLEX.html A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. 13/13 Gene Ontology CC GO:0043240 0.0325742699545858 0.0344729523563103 285 404.454545454545 410 0.00300607466736519 150 0.900537067818123 0.900537067818123 1 0.651594991353725 283 561 381 521 541 224 150 410 553 463 362 455 M17339 GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_LARGE_RIBOSOMAL_SUBUNIT.html The large subunit of a ribosome located in the cytosol. 69/129 Gene Ontology CC GO:0022625 0.00506980009511739 0.00557870048345304 125 374.636363636364 410 0.000461956459205554 118 0.537748586143205 -0.538217327018397 -1 0.593357369432767 124 523 496 410 528 208 118 252 580 535 347 456 M17443 GO_NUCLEAR_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. 59/73 Gene Ontology CC GO:0005637 2.23075794937671e-05 3.78967944031541e-05 470 392.818181818182 410 2.02798233559731e-06 290 1.11600849205707 -1.06383795044511 -1 2.65300498477934 468 333 410 434 320 412 360 290 448 371 475 457 M17101 GO_PERINUCLEAR_REGION_OF_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERINUCLEAR_REGION_OF_CYTOPLASM.html Cytoplasm situated near, or occurring around, the nucleus. 774/983 Gene Ontology CC GO:0048471 1.047597193681e-06 6.94007103560441e-06 530 336.545454545455 411 1.04759768753827e-07 39 1.94815204129124 2.0763482106547 1 5.48337566499904 529 136 515 286 39 530 463 467 229 97 411 458 M17473 GO_INTERSTITIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTITIAL_MATRIX.html A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. 16/18 Gene Ontology CC GO:0005614 0.000115047818873959 0.000155810682437693 450 357.090909090909 411 1.04594396071263e-05 139 2.77003027273953 -2.89176394171974 -1 5.75825966353807 448 418 139 288 411 522 489 189 311 266 447 459 M17630 GO_INTEGRATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRATOR_COMPLEX.html A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. 14/14 Gene Ontology CC GO:0032039 0.0106319617583866 0.0115031094629844 390 436.636363636364 411 0.000971244844564721 243 0.655207185334059 0.671743264695287 1 0.625873973297763 386 554 411 520 529 315 243 361 534 571 379 460 M17781 GO_CYTOSOLIC_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_RIBOSOME.html A ribosome located in the cytosol. 124/214 Gene Ontology CC GO:0022626 0.00392710426157604 0.00437936195004929 95 372.090909090909 411 0.000357648354327866 91 0.696033442076625 -0.684576989200772 -1 0.831195419347542 91 512 509 411 523 219 122 239 557 580 330 461 M16994 GO_RETROMER_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROMER_COMPLEX.html A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. 23/25 Gene Ontology CC GO:0030904 8.75595703950215e-05 0.000124095865061177 415 392.363636363636 412 7.96027776754659e-06 326 0.845439411483397 -0.977988061784978 -1 1.7501254360629 446 412 419 351 395 415 344 326 417 460 331 462 M17088 GO_SECRETORY_GRANULE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_LUMEN.html The volume enclosed by the membrane of a secretory granule. 65/169 Gene Ontology CC GO:0034774 3.32771931725612e-06 1.0017642089771e-05 530 386.545454545455 413 3.02520395524907e-07 59 3.11031204186077 3.1103595116886 1 8.52614576662135 530 402 59 413 172 519 574 576 350 124 533 463 M17530 GO_AXON_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_CYTOPLASM.html Any cytoplasm that is part of a axon. 34/40 Gene Ontology CC GO:1904115 0.000676398052871051 0.000811957166772894 415 426.909090909091 413 6.1509645771463e-05 333 1.36507787417606 -0.784224664951747 -1 2.25707367272291 413 529 333 386 474 396 382 456 391 431 505 464 M17258 GO_CYTOSOLIC_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PROTEASOME_COMPLEX.html A proteasome complex found in the cytosol of a cell. 13/14 Gene Ontology CC GO:0031597 0.0491296830293435 0.0513387515108787 545 420.272727272727 416 0.00456930976226544 300 0.447199928115536 0.453911885937583 1 0.241954793977103 306 382 416 352 545 340 300 426 541 555 460 465 M17467 GO_CATALYTIC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_COMPLEX.html A protein complex which is capable of catalytic activity. 1033/1220 Gene Ontology CC GO:1902494 1.16762605093139e-05 2.26130245197045e-05 420 446.545454545455 416 1.16763218605443e-06 285 1.24795777965062 1.36497398104601 1 3.13063451803367 420 569 542 578 285 338 413 407 383 561 416 466 M17021 GO_SPERM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_PART.html Any constituent part of a sperm, a mature male germ cell that develops from a spermatid. 128/232 Gene Ontology CC GO:0097223 3.51501885182318e-06 1.03142724894408e-05 565 399 417 3.19547678900668e-07 161 1.81751659978296 1.89685741269868 1 4.93746840698399 565 327 211 417 177 563 556 495 364 161 553 467 M17061 GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS.html A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 247/294 Gene Ontology CC GO:0061695 1.27244557978255e-05 2.43187790083442e-05 480 416.818181818182 418 1.15677539951663e-06 278 1.25066982630204 1.3571085591624 1 3.11575043593752 479 388 487 505 284 398 455 368 278 525 418 468 M17087 GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_REGULATORY_PARTICLE_BASE_SUBCOMPLEX.html The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. 13/15 Gene Ontology CC GO:0008540 0.109067613644173 0.112554677668321 290 425.545454545455 418 0.010443874524105 247 0.481489088633694 0.474500965414042 1 0.175597860616224 288 559 418 354 555 298 247 413 565 547 437 469 M17470 GO_AXONEME_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_PART.html Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 18/32 Gene Ontology CC GO:0044447 8.38709787544638e-06 1.82505762757841e-05 575 410.181818181818 418 7.62466349990424e-07 181 2.19102670970642 2.01139141393727 1 5.6675463420092 575 342 181 418 245 550 581 533 386 191 510 470 M17780 GO_PROTEASOME_ACCESSORY_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ACCESSORY_COMPLEX.html A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. 25/28 Gene Ontology CC GO:0022624 0.0264507266878563 0.0280948303576682 335 434.272727272727 418 0.00243401849343427 288 0.512108659768619 0.4814283574884 1 0.362452892175658 333 414 469 407 537 325 288 418 543 579 464 471 M17593 GO_CIS_GOLGI_NETWORK http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIS_GOLGI_NETWORK.html The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. 49/52 Gene Ontology CC GO:0005801 9.42261125872307e-06 1.93446542096046e-05 420 414.181818181818 420 8.56604692368846e-07 221 1.04129303769514 -0.777747477504816 -1 2.63848326072465 506 221 397 420 261 494 505 488 418 350 496 472 M17078 GO_COPI_VESICLE_COAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_VESICLE_COAT.html One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. 13/13 Gene Ontology CC GO:0030126 1.15639556322199e-05 2.26130245197045e-05 425 356.454545454545 421 1.05127421970817e-06 122 0.946688060271723 -0.803890537351794 -1 2.35624900797389 438 422 366 145 274 422 296 521 122 421 494 473 M17463 GO_BLOC_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOC_COMPLEX.html Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. 20/21 Gene Ontology CC GO:0031082 0.000252508579946701 0.000322434032855018 250 348.272727272727 421 2.29579606079787e-05 89 0.766502664202166 -0.754904343441395 -1 1.4036514675573 247 542 421 506 441 199 89 170 559 500 157 474 M17767 GO_AXONEMAL_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX.html A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 13/21 Gene Ontology CC GO:0005858 6.00499525659561e-05 8.96890037039088e-05 525 405.272727272727 421 5.45923561073186e-06 171 2.69688322101989 2.46168549611871 1 5.96207596057268 521 454 171 367 374 463 499 421 390 230 568 475 M17425 GO_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLTRANSFERASE_COMPLEX.html A protein complex that possesses methyltransferase activity. 103/119 Gene Ontology CC GO:0034708 0.000154773396422836 0.000205304436807461 425 422.363636363636 424 1.40712987311614e-05 316 1.05342069978268 1.26996387049945 1 2.07220038274188 424 394 470 457 421 452 466 348 316 514 384 476 M17448 GO_EXOSOME_RNASE_COMPLEX_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOSOME_RNASE_COMPLEX_.html Complex of 3'-5' exoribonucleases. 22/25 Gene Ontology CC GO:0000178 0.000273007780917683 0.000347845440160469 155 364.545454545455 426 2.48219695958158e-05 80 0.696528992307429 0.733381238527008 1 1.25577549853873 155 536 426 546 442 196 80 260 520 505 344 477 M17706 GO_NUCLEAR_PORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE.html Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. 82/99 Gene Ontology CC GO:0005643 0.000179968624578804 0.000235499483964607 515 360.272727272727 426 1.63621225821909e-05 102 0.964010532132661 0.918534568783649 1 1.85798922291589 140 514 485 550 426 203 102 269 475 511 288 478 M17247 GO_SET1C_COMPASS_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SET1C_COMPASS_COMPLEX.html A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. 9/11 Gene Ontology CC GO:0048188 0.000171130790586031 0.000224947939661728 435 429.363636363636 430 1.71143970600909e-05 282 0.502625291586439 0.476145853357983 1 0.937360891112665 432 322 524 282 430 409 412 502 481 554 375 479 M17388 GO_U5_SNRNP http://www.broadinstitute.org/gsea/msigdb/cards/GO_U5_SNRNP.html A ribonucleoprotein complex that contains small nuclear RNA U5. 16/20 Gene Ontology CC GO:0005682 0.00577323454429378 0.0063049798312682 340 406.727272727273 430 0.000526221867859292 124 0.575524819050689 0.611909132082112 1 0.623532907974723 337 489 430 504 522 253 124 356 548 556 355 480 M17799 GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_POTASSIUM_EXCHANGING_ATPASE_COMPLEX.html Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. 8/14 Gene Ontology CC GO:0005890 0.00032777954550102 0.000412207610251283 465 387.090909090909 431 3.27827903283795e-05 148 2.3206727595743 1.93168226141289 1 4.26911675022304 465 321 578 293 452 380 504 148 431 165 521 481 M17131 GO_INCLUSION_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INCLUSION_BODY.html A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. 78/96 Gene Ontology CC GO:0016234 1.16207672590115e-05 2.26130245197045e-05 570 432.090909090909 434 1.05643896748164e-06 256 1.37303490623988 -1.23576976973611 -1 3.45213352122031 569 434 361 404 275 540 572 256 428 452 462 482 M17474 GO_EXTRACELLULAR_SPACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_SPACE.html That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. 1040/2139 Gene Ontology CC GO:0005615 5.28769368074067e-41 7.68037507127582e-39 510 351.454545454545 435 5.28769368074066e-42 2 2.83082725542357 2.86694889289682 1 59.6210426336261 508 128 543 327 56 500 540 435 269 2 558 483 M17135 GO_CELL_PROJECTION_CYTOPLASM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_CYTOPLASM.html All of the contents of a cell projection, excluding the plasma membrane surrounding the projection. 59/73 Gene Ontology CC GO:0032838 5.56795037646686e-05 8.44642080607636e-05 325 414.272727272727 436 5.06190118178771e-06 322 1.56560662230853 -1.10926821617034 -1 3.45135915437325 460 436 322 326 369 450 492 527 325 370 480 484 M17497 GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U4_U6_X_U5_TRI_SNRNP_COMPLEX.html A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. 19/24 Gene Ontology CC GO:0046540 0.00427517054322326 0.00474928123444114 265 389.909090909091 436 0.000389409180055513 182 0.695737867814866 0.804633774811354 1 0.8172529765866 262 487 436 455 515 262 182 329 524 469 368 485 M17617 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_MEMBRANE.html The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 49/59 Gene Ontology CC GO:0098573 4.42303288766109e-05 6.87107515436121e-05 380 430.181818181818 437 4.02101983081e-06 311 0.947756889750346 0.712622671076153 1 2.10589189880656 376 437 465 522 358 317 311 529 396 515 506 486 M17699 GO_NUCLEOLUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLUS.html A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. 971/1232 Gene Ontology CC GO:0005730 5.54679311060669e-05 8.43635287241488e-05 575 472.272727272727 440 5.54693156658278e-06 369 1.29246883945335 1.378666045435 1 2.83614582362271 369 571 570 558 376 418 451 429 440 574 439 487 M17069 GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADA2_GCN5_ADA3_TRANSCRIPTION_ACTIVATOR_COMPLEX.html A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. 16/16 Gene Ontology CC GO:0005671 0.0249832075104804 0.0265846951714086 345 424.272727272727 441 0.00229741009233234 121 0.622211532767401 0.59271318662596 1 0.465222011456427 341 558 441 477 567 307 121 383 561 545 366 488 M17390 GO_HISTONE_METHYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLTRANSFERASE_COMPLEX.html A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. 84/95 Gene Ontology CC GO:0035097 9.03668943974522e-05 0.000127126309067602 400 449.272727272727 444 8.21550968262952e-06 249 1.12782997615054 1.483148628738 1 2.35391790132273 580 400 443 474 397 565 496 385 249 509 444 489 M17136 GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_TWO_SECTOR_ATPASE_COMPLEX_PROTON_TRANSPORTING_DOMAIN.html A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. 19/26 Gene Ontology CC GO:0033177 0.000318259626720669 0.000401103781181581 250 413.090909090909 445 2.89368796898432e-05 249 1.12203445079833 -1.26061606362293 -1 2.03162567243166 249 485 363 494 445 447 531 307 438 468 317 490 M17066 GO_TELOMERASE_HOLOENZYME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERASE_HOLOENZYME_COMPLEX.html Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. 21/23 Gene Ontology CC GO:0005697 0.00529482299265891 0.00581529708645525 210 386.090909090909 447 0.00048250994058662 132 0.579112886054377 0.606368347415033 1 0.639151612810123 207 537 447 507 539 206 132 254 562 544 312 491 M17242 GO_COPI_COATED_VESICLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPI_COATED_VESICLE_MEMBRANE.html The lipid bilayer surrounding a COPI-coated vesicle. 20/20 Gene Ontology CC GO:0030663 5.29861595721886e-06 1.34432134111099e-05 450 421.454545454545 447 4.81693519888728e-07 207 0.940493554257541 -0.716749027613435 -1 2.45785496994288 535 370 405 263 207 513 448 540 329 447 579 492 M17248 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY.html A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. 71/84 Gene Ontology CC GO:0000932 0.000947927081901073 0.00112397068282556 485 436.363636363636 447 8.62123424936959e-05 299 1.22298508632884 -1.28031629116318 -1 1.91854327082951 447 299 438 384 482 511 512 483 363 486 395 493 M17519 GO_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of a membrane. 882/1255 Gene Ontology CC GO:0098796 1.26561502291848e-06 7.00306979348224e-06 250 391.545454545455 448 1.26561574372068e-07 65 1.86794459729291 -1.69242146107524 -1 5.25038802708666 445 247 550 462 65 534 520 492 296 248 448 494 M17236 GO_NUCLEAR_NUCLEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_NUCLEOSOME.html A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures. 16/61 Gene Ontology CC GO:0000788 0.0905542381264597 0.0936156803406995 320 441.909090909091 449 0.00859195976325674 318 0.954127141802788 -1.2168781792203 -1 0.465914673874783 319 378 318 438 553 481 330 567 554 449 474 495 M17011 GO_INFLAMMASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMASOME_COMPLEX.html A cytosolic protein complex that is capable of activating caspase-1. 6/12 Gene Ontology CC GO:0061702 0.311830772682997 0.31693222320079 455 449.363636363636 452 0.0366823337994851 266 2.18336715678298 1.59721443687751 1 0.52573094536251 451 498 512 427 577 443 266 474 522 321 452 496 M17435 GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_ACETYLTRANSFERASE_COMPLEX.html A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. 9/10 Gene Ontology CC GO:0031414 0.443840832042371 0.448472214637596 570 476.181818181818 452 0.0569821572252275 327 0.569755087420228 0.569755087420228 1 0.0326639218959614 327 566 538 405 579 413 399 452 567 559 433 497 M17264 GO_ENDOPLASMIC_RETICULUM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_PART.html Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. 1099/1512 Gene Ontology CC GO:0044432 1.03684063764893e-06 6.94007103560441e-06 455 365.636363636364 453 1.03684112141657e-07 37 1.88330137953903 -1.67844760227986 -1 5.29827611598381 453 129 525 512 37 459 445 544 221 168 529 498 M17167 GO_PORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX.html Any small opening in a membrane that allows the passage of gases and/or liquids. 16/21 Gene Ontology CC GO:0046930 4.01846067425032e-05 6.35425573474822e-05 485 418 455 3.65321279658764e-06 227 1.99588390840822 0.827074066136931 1 4.55759742853146 485 377 227 488 351 544 483 394 462 332 455 499 M17317 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX.html A spliceosomal snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. 24/31 Gene Ontology CC GO:0097526 0.00458161466780356 0.00507032023236927 150 369 455 0.000417380366452402 91 0.668178754242073 0.734651778112444 1 0.771323276167869 149 481 455 458 516 204 91 327 537 489 352 500 M17288 GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTIONAL_REPRESSOR_COMPLEX.html A protein complex that possesses activity that prevents or downregulates transcription. 84/99 Gene Ontology CC GO:0017053 1.99406059082438e-05 3.42813703819297e-05 460 448.363636363636 457 1.81279878640273e-06 315 1.16322892382499 1.07430880134438 1 2.79654734650247 457 431 440 497 315 489 515 471 451 461 405 501 M17114 GO_CYTOSOLIC_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_PART.html Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. 219/339 Gene Ontology CC GO:0044445 7.49399790037852e-06 1.67208605216644e-05 460 441.818181818182 458 6.81274857070459e-07 237 0.960005697829633 -0.833092499643127 -1 2.46011655818841 329 581 501 533 237 395 310 457 509 550 458 502 M17155 GO_TRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFERASE_COMPLEX.html A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). 713/832 Gene Ontology CC GO:1990234 1.54915118778411e-05 2.82149479655977e-05 405 455.272727272727 458 1.54916198730238e-06 304 1.19093025045311 1.33759171173514 1 2.92071341233574 458 572 518 556 304 403 469 401 368 551 408 503 M17206 GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EUKARYOTIC_TRANSLATION_INITIATION_FACTOR_3_COMPLEX.html A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. 17/18 Gene Ontology CC GO:0005852 0.445297475390733 0.449162904864611 460 470.545454545455 459 0.0521650028461814 337 0.484510087504403 -0.484510087504403 -1 0.0160586680917598 350 556 458 529 576 357 337 459 573 552 429 504 M17808 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX.html A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. 22/28 Gene Ontology CC GO:0045259 0.235577813212319 0.240546062348607 190 446.818181818182 459 0.0241255786029572 190 0.543259856375688 0.543259856375688 1 0.108877255682228 190 546 459 551 562 323 258 436 574 581 435 505 M17717 GO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOST.html Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. 17/20 Gene Ontology CC GO:0018995 0.000898690368792156 0.00107215421820994 550 460.181818181818 464 8.1732517269036e-05 293 1.7015771395167 -1.50094646034287 -1 2.71880779833992 548 450 293 464 479 580 546 402 385 345 570 506 M17048 GO_OXIDOREDUCTASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTASE_COMPLEX.html Any protein complex that possesses oxidoreductase activity. 90/106 Gene Ontology CC GO:1990204 0.0493200663372221 0.0514451679388259 515 439.818181818182 465 0.00458743006491989 205 1.06832881277254 1.05690315226163 1 0.684600569840965 205 511 479 564 546 344 319 445 447 513 465 507 M17067 GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE.html The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 274/347 Gene Ontology CC GO:0031300 4.40628805397863e-06 1.21728790073618e-05 480 438.454545454545 465 4.00572443561233e-07 189 1.50496611535408 -1.40797334833019 -1 4.01521476129147 477 387 414 485 189 572 567 500 337 465 430 508 M17755 GO_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REGION.html A membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane. 1088/1581 Gene Ontology CC GO:0098589 3.48696408505066e-28 2.53240766676804e-26 5 313.909090909091 465 3.48696408505069e-29 1 2.37825056795113 2.48837632900683 1 33.6045512617864 559 127 575 1 40 581 465 479 153 4 469 509 M17422 GO_MLL1_2_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MLL1_2_COMPLEX.html A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. 31/35 Gene Ontology CC GO:0044665 0.000139967445412357 0.000186945024792137 460 476.636363636364 466 1.2725122832153e-05 419 0.744876681598258 -0.777686072597942 -1 1.45943679316405 487 443 460 451 419 527 564 491 457 478 466 510 M17586 GO_OUTER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_MEMBRANE.html The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. 205/257 Gene Ontology CC GO:0019867 1.18203046094804e-05 2.28159368043459e-05 470 456.636363636364 467 1.07457891989706e-06 280 1.47660048907373 -1.32368582633796 -1 3.71516946861022 492 467 407 467 280 555 516 551 336 448 504 511 M17104 GO_INO80_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INO80_TYPE_COMPLEX.html A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. 23/26 Gene Ontology CC GO:0097346 1.31544353707067e-05 2.48140485401967e-05 575 457.727272727273 468 1.19586491141211e-06 289 0.735283111568393 0.797005053764699 1 1.79644143141402 573 364 412 437 289 509 468 568 484 434 497 512 M17575 GO_AUTOPHAGOSOME_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_MEMBRANE.html The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. 27/34 Gene Ontology CC GO:0000421 6.31990491398224e-05 9.3194536929535e-05 545 434.272727272727 469 5.74553315653152e-06 173 0.905579058360589 -0.815382356094498 -1 1.94241953083987 541 479 406 502 380 506 391 469 494 436 173 513 M17743 GO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM.html The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). 1541/2134 Gene Ontology CC GO:0005783 1.23033961560629e-06 6.94007103560441e-06 525 377.727272727273 471 1.23034029678783e-07 62 1.9346412268927 -1.67093529008507 -1 5.44481251723111 525 119 573 460 62 528 471 505 223 108 581 514 M16993 GO_NUCLEAR_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE.html The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). 452/592 Gene Ontology CC GO:0005635 8.53783354968333e-06 1.84404509009889e-05 545 472.727272727273 472 7.76169698524839e-07 248 1.42734492123355 1.41487056954707 1 3.66169324048968 545 464 480 540 248 470 472 573 392 471 545 515 M17039 GO_CYTOPLASMIC_STRESS_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_STRESS_GRANULE.html A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. 36/44 Gene Ontology CC GO:0010494 0.000459229310551467 0.000561709956695584 445 477.454545454545 474 4.17568362158583e-05 444 1.13550400831409 -1.27338934773252 -1 1.96505281132058 474 444 445 453 463 553 523 446 489 480 482 516 M17415 GO_SMALL_SUBUNIT_PROCESSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_SUBUNIT_PROCESSOME.html A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 32/36 Gene Ontology CC GO:0032040 0.479844367906508 0.482334909608445 475 483.545454545455 475 0.0576897030234145 343 0.790099193754539 0.825937971332248 1 0.0613026985063412 343 535 475 459 566 474 479 454 551 520 463 517 M17650 GO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins. 147/223 Gene Ontology CC GO:0000781 0.000691265620826661 0.000828093455052145 185 366.090909090909 475 6.28620836482051e-05 158 1.12543036180673 1.16719081547548 1 1.84196979797595 183 504 490 555 475 168 158 210 492 521 271 518 M17759 GO_MEDIATOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEDIATOR_COMPLEX.html A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. 36/36 Gene Ontology CC GO:0016592 4.1833668298537e-06 1.1685269846851e-05 445 468.636363636364 475 3.80306798606726e-07 186 1.13065636628448 -0.936376492551843 -1 3.00849007830818 581 475 431 561 186 541 441 490 456 445 548 519 M16976 GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_TELOMERIC_REGION.html The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. 117/187 Gene Ontology CC GO:0000784 0.000713021994648913 0.00085239872199798 120 338.272727272727 476 6.4841199148528e-05 90 1.14408605934756 1.17399786033704 1 1.86582879522577 117 508 478 553 476 116 90 150 490 512 231 520 M17543 GO_NADH_DEHYDROGENASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX.html An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. 45/51 Gene Ontology CC GO:0030964 0.175170340380595 0.180450297448805 480 426.636363636364 477 0.017354766792949 142 0.768099461997276 0.804131187465649 1 0.238913091527808 142 528 477 480 561 324 222 444 546 518 451 521 M17018 GO_TRANSCRIPTION_EXPORT_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_EXPORT_COMPLEX.html The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. 20/40 Gene Ontology CC GO:0000346 0.00298997799639802 0.00337972220993628 340 451.363636363636 478 0.000272186306106074 289 0.64412849681308 0.445764736034188 1 0.80356459266309 338 547 444 478 504 313 289 579 560 499 414 522 M17221 GO_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_LIGASE_COMPLEX.html A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. 256/305 Gene Ontology CC GO:0000151 1.16456574768289e-05 2.26130245197045e-05 480 455.636363636364 478 1.05870173848623e-06 276 1.2595918143002 1.43802420649051 1 3.16053871110935 490 579 491 548 276 361 478 478 415 508 388 523 M17576 GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_COMPONENT_OF_MITOCHONDRIAL_INNER_MEMBRANE.html The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. 21/24 Gene Ontology CC GO:0031304 0.00427212733868794 0.00474928123444114 515 453.454545454545 478 0.000389131445852837 301 0.726610295782318 0.638496617111591 1 0.856939733861617 378 484 433 473 514 366 301 543 515 503 478 524 M17628 GO_PLASMA_MEMBRANE_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_REGION.html A membrane that is a (regional) part of the plasma membrane. 883/1317 Gene Ontology CC GO:0098590 1.64231943358565e-30 1.36312512987609e-28 545 315.545454545455 479 1.64231943358565e-31 2 2.45477185490506 2.54906492943754 1 37.7700519137899 542 132 560 2 52 479 542 512 134 3 513 525 M17745 GO_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATION_PREINITIATION_COMPLEX.html A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. 16/16 Gene Ontology CC GO:0070993 0.0399652081898504 0.0419887630349062 365 461.909090909091 479 0.00370093040459734 309 0.44250793875397 -0.484510087504403 -1 0.259984311528202 365 493 451 479 543 348 309 524 569 577 423 526 M17567 GO_POLYSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSOME.html A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. 45/60 Gene Ontology CC GO:0005844 7.21357175938065e-05 0.000104515840204493 480 475.090909090909 480 6.55800754161185e-06 353 1.11331269309632 1.46990729685811 1 2.37501778703507 498 527 454 562 385 480 461 522 353 507 477 527 M17846 GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX.html A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs. 61/70 Gene Ontology CC GO:0030532 0.000929257845538619 0.001106350016922 520 409.363636363636 480 8.45136897236738e-05 180 0.746304025213907 0.743572403885555 1 1.14352882293969 253 518 486 509 480 264 180 380 518 519 396 528 M17458 GO_MITOCHONDRIAL_MEMBRANE_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_PART.html Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. 170/199 Gene Ontology CC GO:0044455 0.0205841579418851 0.0219438454389637 505 419.636363636364 481 0.00188902849698872 96 0.998052465635512 0.885770931209915 1 0.838830868774399 96 502 503 571 536 279 221 481 450 537 440 529 M17017 GO_PHOSPHATASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATASE_COMPLEX.html A protein complex which is capable of phosphatase activity. 49/58 Gene Ontology CC GO:1903293 4.59862014376411e-06 1.23124345784652e-05 530 435 482 4.18057250564056e-07 194 1.20284840841072 -0.901626766578981 -1 3.19039455629596 528 473 398 517 194 515 334 556 227 482 561 530 M17102 GO_NUCLEOLAR_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOLAR_PART.html Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. 60/65 Gene Ontology CC GO:0044452 0.00246289094312488 0.00281127630246671 185 417.909090909091 483 0.000224150224408153 181 0.780018988187733 0.840711506332081 1 1.0238783020435 181 519 483 552 497 301 277 354 530 522 381 531 M17563 GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR.html A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. 22/26 Gene Ontology CC GO:0030687 0.00290020168569713 0.00329104917849616 450 476.636363636364 483 0.000264002910523955 403 0.641005504453498 0.680452844707282 1 0.803389845776101 403 449 448 456 502 483 509 443 544 506 500 532 M17638 GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CUL4_RING_E3_UBIQUITIN_LIGASE_COMPLEX.html A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. 26/29 Gene Ontology CC GO:0080008 0.00572099374583742 0.00625969372190497 525 485.909090909091 483 0.000521447754766454 401 0.65681171612657 -0.574198951696274 -1 0.723631068777367 483 480 462 525 521 454 474 520 527 498 401 533 M17436 GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTON_TRANSPORTING_ATP_SYNTHASE_COMPLEX_COUPLING_FACTOR_F_O_.html All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. 11/16 Gene Ontology CC GO:0045263 0.232650201696328 0.238394651120929 565 471.272727272727 484 0.0237864014738059 238 0.636998805912256 0.636998805912256 1 0.142346699277527 353 565 394 563 570 405 238 475 577 560 484 534 M17053 GO_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). 105/168 Gene Ontology CC GO:0015934 0.000243875235454823 0.000312095840967516 365 473.545454545455 485 2.21729339819363e-05 364 0.615831331231489 -0.590229177004229 -1 1.11739807395729 364 515 499 534 439 467 373 419 571 543 485 535 M17396 GO_SAGA_TYPE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_TYPE_COMPLEX.html A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. 31/36 Gene Ontology CC GO:0070461 0.0161837447512678 0.0174125105564566 535 451.454545454545 486 0.00148218518942081 313 0.732417927114263 0.773520338560323 1 0.635754075631123 361 532 464 527 532 333 313 486 502 517 399 536 M17583 GO_ORGANELLE_ENVELOPE_LUMEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ENVELOPE_LUMEN.html The region between the inner and outer lipid bilayers of an organelle envelope. 95/115 Gene Ontology CC GO:0031970 8.97102375921898e-06 1.87171513937175e-05 510 458.454545454545 486 8.15550940082996e-07 255 1.193755859707 1.01707927872141 1 3.04555295278904 509 354 432 539 255 497 486 577 444 400 550 537 M17325 GO_RIBONUCLEOPROTEIN_GRANULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_GRANULE.html A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. 167/225 Gene Ontology CC GO:0035770 3.73655788656904e-05 5.96412124202366e-05 515 454.727272727273 487 3.3969285010001e-06 287 1.50994095595483 -1.28174171120308 -1 3.45215990280828 501 468 395 515 347 551 506 431 287 487 514 538 M17402 GO_PRC1_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRC1_COMPLEX.html A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. 12/12 Gene Ontology CC GO:0035102 0.0396389731329705 0.0417214554171302 495 451.727272727273 493 0.00367015713632931 276 0.755581856939752 -0.56892597909271 -1 0.499647437649708 546 494 327 493 542 364 276 493 564 409 461 539 M17711 GO_NUCLEAR_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_MEMBRANE.html Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. 311/392 Gene Ontology CC GO:0031965 7.45976205682254e-06 1.67208605216644e-05 570 474 493 6.7816248650098e-07 236 1.44228306834683 1.38762114556383 1 3.73474812395049 567 465 468 541 236 533 507 580 421 403 493 540 M17495 GO_RESPIRATORY_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN.html The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. 76/93 Gene Ontology CC GO:0070469 0.187516360148971 0.192826557958499 120 437 494 0.0187010604352372 120 0.716264450456733 0.760720945321419 1 0.206168176251624 120 517 494 569 558 341 254 434 542 528 450 541 M17484 GO_CATALYTIC_STEP_2_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATALYTIC_STEP_2_SPLICEOSOME.html A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. 103/158 Gene Ontology CC GO:0071013 0.00221478232229586 0.00253804443639821 295 444.454545454545 495 0.000201546830349164 262 0.642983454438187 0.65497912650487 1 0.84624896200927 293 509 505 511 495 346 262 427 549 538 454 542 M17577 GO_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DYNEIN_COMPLEX.html Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. 35/52 Gene Ontology CC GO:0030286 0.0166913204402295 0.0178923564128659 570 457.363636363636 496 0.00152902895725133 306 2.01101386780055 -1.86700350581045 -1 1.86710193172781 566 530 316 501 540 496 409 306 437 361 569 543 M17688 GO_WASH_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_WASH_COMPLEX.html A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. 10/11 Gene Ontology CC GO:0071203 0.0825345068984774 0.0856295509071703 570 487 496 0.00780035531507401 379 1.00239705763675 -0.855293879974763 -1 0.514864977815852 570 496 379 385 551 538 457 489 531 442 519 544 M17526 GO_U2_TYPE_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. 15/18 Gene Ontology CC GO:0071004 0.0847615492049547 0.0877833513156482 505 487.454545454545 499 0.00801954735008894 388 0.575845189452816 0.54403991303214 1 0.259517599242975 505 453 388 443 552 468 439 510 538 567 499 545 M17539 GO_DNA_HELICASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_HELICASE_COMPLEX.html A protein complex that possesses DNA helicase activity. 15/18 Gene Ontology CC GO:0033202 5.39191260387171e-05 8.22231292086473e-05 380 473.363636363636 499 4.90185887012765e-06 368 0.773304498445189 -0.679840442227494 -1 1.67070670154083 568 379 376 402 368 577 502 578 499 398 560 546 M17542 GO_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX.html Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. 190/251 Gene Ontology CC GO:0005681 0.00119309646675764 0.00140321669470889 500 455.909090909091 499 0.00010852218131204 285 0.772596518847805 0.7154353600129 1 1.14240375520278 296 500 506 557 487 345 285 499 519 568 453 547 M17089 GO_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME.html An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. 235/339 Gene Ontology CC GO:0005840 8.7785543098354e-05 0.000124095865061177 370 486 500 7.98082237803656e-06 368 0.739266194344083 -0.725533192924046 -1 1.52065314283267 368 501 500 581 396 514 446 453 552 548 487 548 M17404 GO_PROTEASOME_CORE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_CORE_COMPLEX.html A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. 18/22 Gene Ontology CC GO:0005839 0.479213427614229 0.482334909608445 540 474.363636363636 500 0.0575858505422503 298 0.657592094471416 0.485859102052193 1 0.0380872817147947 391 545 434 500 571 400 298 536 514 490 539 549 M17826 GO_ACETYLTRANSFERASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLTRANSFERASE_COMPLEX.html A protein complex which is capable of acetyltransferase activity. 100/110 Gene Ontology CC GO:1902493 0.00550505270837333 0.00603478419540548 535 484.727272727273 500 0.000501716039574439 376 1.0019481751199 1.32784097134205 1 1.15321535643255 495 513 484 531 519 521 500 376 404 532 457 550 M17241 GO_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of a ribosome. 70/104 Gene Ontology CC GO:0015935 0.516607097084278 0.517497798975803 500 501.636363636364 502 0.0639478943966976 358 0.62482160410684 -0.505445505461407 -1 0.0217810129479417 358 526 495 532 568 499 429 498 575 536 502 551 M17292 GO_EXON_EXON_JUNCTION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXON_EXON_JUNCTION_COMPLEX.html A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. 26/51 Gene Ontology CC GO:0035145 0.00749198283426844 0.00815138956312727 530 486.818181818182 502 0.000683419880775863 322 0.691865180765512 -0.781351090912034 -1 0.72246712752867 502 534 457 475 525 442 322 565 526 477 530 552 M17305 GO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MATRIX.html The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. 443/496 Gene Ontology CC GO:0005759 1.8605157486741e-05 3.2657391238056e-05 385 462.363636363636 502 1.69139225730635e-06 310 1.30003342481687 1.26367505135431 1 3.14967322980408 382 577 502 566 310 392 350 562 370 529 546 553 M17493 GO_HEMOGLOBIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_COMPLEX.html An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. 3/15 Gene Ontology CC GO:0005833 0.356061390867445 0.361032579570655 505 487.454545454545 503 0.0430605770979437 278 0.315038860149213 -0.315038860149213 -1 0 456 462 548 350 578 502 278 539 581 565 503 554 M17461 GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_PROTEIN_COMPLEX.html Any protein complex that is part of the inner mitochondrial membrane. 105/124 Gene Ontology CC GO:0098800 0.0393924772107654 0.0415372581841283 415 419.363636363636 504 0.0036469118445204 49 0.729473335103819 0.742887357979422 1 0.480493168669109 49 510 504 575 556 299 216 411 539 539 415 555 M17590 GO_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SUBUNIT.html Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. 175/272 Gene Ontology CC GO:0044391 0.00315087349580869 0.00354778585477684 510 486.363636363636 506 0.000286854117642513 315 0.619363224146805 -0.556761938237326 -1 0.762481465055308 315 506 507 580 507 478 363 460 572 570 492 556 M17748 GO_MITOCHONDRIAL_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PROTEIN_COMPLEX.html A protein complex that is part of a mitochondrion. 133/156 Gene Ontology CC GO:0098798 0.036492715376761 0.0385495775161785 510 419.363636363636 507 0.00337386210886943 48 0.732884158013254 0.751473812504016 1 0.496246034114906 48 507 508 576 554 278 207 409 535 578 413 557 M17478 GO_PRESPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESPLICEOSOME.html A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. 20/24 Gene Ontology CC GO:0071010 0.0180163950411049 0.0192417748508859 515 494.818181818182 508 0.00165142274636551 397 0.560885803333984 0.53805052276892 1 0.455334764638464 513 482 424 498 535 466 397 508 540 562 518 558 M17441 GO_ENDORIBONUCLEASE_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDORIBONUCLEASE_COMPLEX.html A protein complex which is capable of endoribonuclease activity. 21/22 Gene Ontology CC GO:1902555 0.0176660972445441 0.0189023987091715 520 473.727272727273 509 0.00161905203247452 318 0.774830636734683 0.828292381430545 1 0.661749405085758 518 544 427 523 534 431 318 509 558 451 398 559 M17276 GO_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRERIBOSOME.html Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. 60/70 Gene Ontology CC GO:0030684 0.0650176581509198 0.0676975974653843 550 491.545454545455 510 0.00609296537722062 330 0.699203417135157 0.751154294133588 1 0.375286730538344 330 524 492 510 547 476 527 447 547 526 481 560 M17578 GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_LARGE_RIBOSOMAL_SUBUNIT.html The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). 33/36 Gene Ontology CC GO:0000315 0.283652149711897 0.289126138565986 270 459.545454545455 510 0.029871080482921 251 0.836873677920399 0.751307985367522 1 0.1724129369869 267 533 473 530 574 371 251 514 556 510 476 561 M17502 GO_STAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAGA_COMPLEX.html A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs. 15/17 Gene Ontology CC GO:0030914 0.526720470256085 0.526720470256085 570 495.454545454545 511 0.0657453946702805 374 0.558717184517257 0.517886837672915 1 0.0089455757726725 480 552 420 526 569 401 374 511 568 566 483 562 M17666 GO_MHC_CLASS_II_PROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_MHC_CLASS_II_PROTEIN_COMPLEX.html A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. 8/11 Gene Ontology CC GO:0042613 0.000111933747878123 0.000152303296293184 545 433.272727272727 515 1.11939386401611e-05 122 2.27052837403812 -2.43277421712809 -1 4.71842408903077 544 283 566 276 415 578 551 515 354 122 562 563 M16987 GO_90S_PRERIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_90S_PRERIBOSOME.html A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. 24/28 Gene Ontology CC GO:0030686 0.438298062319922 0.443643160640896 545 513.090909090909 517 0.0510839090861086 437 0.607962510677701 0.625400640272253 1 0.0416077972622308 437 543 472 508 565 485 544 463 570 540 517 564 M17498 GO_PRP19_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRP19_COMPLEX.html A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. 19/20 Gene Ontology CC GO:0000974 0.214960921584171 0.220657765795765 555 492.727272727273 520 0.021761701953011 283 0.707576880393696 0.837841926348714 1 0.179808987153526 554 548 399 283 559 520 487 473 578 496 523 565 M17232 GO_ORGANELLE_INNER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INNER_MEMBRANE.html The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. 527/618 Gene Ontology CC GO:0019866 2.45642187324554e-05 4.10109513895305e-05 580 486.181818181818 521 2.45644902670586e-06 333 1.17600606891961 1.04965199641071 1 2.77746253535849 411 576 521 577 333 441 378 575 432 553 551 566 M17286 GO_ORGANELLAR_RIBOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_RIBOSOME.html A ribosome contained within a subcellular membrane-bounded organelle. 71/80 Gene Ontology CC GO:0000313 0.503572864852757 0.505312322071592 525 476.363636363636 521 0.0616810201079852 256 0.785765016791863 0.766122703743176 1 0.0517563436487915 256 521 493 574 573 404 306 534 555 523 501 567 M17429 GO_NUCLEOPLASM_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPLASM_PART.html Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. 746/883 Gene Ontology CC GO:0044451 6.58566367635375e-05 9.64538701312022e-05 515 508.272727272727 522 6.58585885384175e-06 386 1.23273267776969 1.28296289036061 1 2.66182626200001 511 573 537 579 386 484 511 525 406 557 522 568 M17475 GO_CYTOPLASMIC_DYNEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_DYNEIN_COMPLEX.html Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. 23/29 Gene Ontology CC GO:0005868 0.0400452466471601 0.0419969102924188 525 487.272727272727 523 0.00370848176564004 335 1.21957977233894 -1.02154558682169 -1 0.851910392394836 561 540 393 528 575 525 425 335 523 435 520 569 M17739 GO_RIBONUCLEOPROTEIN_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX.html A macromolecular complex containing both protein and RNA molecules. 755/991 Gene Ontology CC GO:1990904 0.000109678205610125 0.000149584594975311 575 526.727272727273 527 1.09683619175124e-05 414 1.02676385345435 1.07113509545751 1 2.09593225814121 527 575 572 559 414 504 525 517 469 576 556 570 M17571 GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DIRECTED_RNA_POLYMERASE_III_COMPLEX.html RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. 19/21 Gene Ontology CC GO:0005666 0.000282293991960749 0.000358769889632076 560 516.636363636364 529 2.56663837409135e-05 415 0.753974066278823 -0.583107146226808 -1 1.36010170267841 560 549 415 524 443 573 533 518 529 497 542 571 M17050 GO_SAGA_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_SAGA_COMPLEX.html A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. 8/9 Gene Ontology CC GO:0000124 0.233103078591398 0.238438184263385 540 518.181818181818 532 0.0261911896230841 403 0.647888646486067 0.725356557265558 1 0.146070238580933 539 461 514 403 563 561 532 530 517 542 538 572 M16996 GO_PROTEASOME_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_COMPLEX.html A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. 77/87 Gene Ontology CC GO:0000502 0.0716440167373078 0.0744636381473629 570 516.636363636364 534 0.00673539820904034 402 0.613381129546436 -0.691040311191985 -1 0.305716044372224 515 516 498 568 549 449 402 549 536 534 567 573 M17672 GO_RNAI_EFFECTOR_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNAI_EFFECTOR_COMPLEX.html Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. 11/11 Gene Ontology CC GO:0031332 0.00138900346304406 0.00162703833070282 490 518.272727272727 535 0.000126352837041281 396 0.450019470193456 -0.451342112236787 -1 0.617219076298061 469 563 396 503 488 535 536 574 576 572 489 574 M17431 GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLAR_SMALL_RIBOSOMAL_SUBUNIT.html The smaller of the two subunits of an organellar ribosome. 24/29 Gene Ontology CC GO:0000314 0.312022773960158 0.31693222320079 550 488.818181818182 538 0.0334284552307022 315 0.630116843222337 0.620796681572791 1 0.0968593365215537 356 538 461 549 564 417 315 548 563 558 508 575 M17071 GO_U2_TYPE_SPLICEOSOMAL_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_U2_TYPE_SPLICEOSOMAL_COMPLEX.html Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. 32/43 Gene Ontology CC GO:0005684 0.00304215255943138 0.00343202065442647 480 523.363636363636 545 0.000276942490866846 467 0.610507833696163 0.509594830609533 1 0.755343866191558 577 478 467 476 505 554 555 477 545 546 577 576 M17489 GO_MITOCHONDRIAL_PART http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_PART.html Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 988/1145 Gene Ontology CC GO:0044429 1.06145367984472e-05 2.1219245197643e-05 495 488.090909090909 545 1.06145874995642e-06 277 1.35574536379348 1.3091845991989 1 3.42841739804204 493 570 545 573 277 448 405 555 360 563 580 577 M17490 GO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION.html A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. 1734/2090 Gene Ontology CC GO:0005739 2.81944608898501e-06 9.1513864675994e-06 575 483 545 2.81944966616571e-07 163 1.48506065512074 1.50141028071775 1 4.0628982159077 572 567 546 545 163 469 449 537 342 564 559 578 M17738 GO_MITOCHONDRIAL_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ENVELOPE.html The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. 713/833 Gene Ontology CC GO:0005740 7.02439965267529e-06 1.6195143643668e-05 575 491.363636363636 550 7.02442185675978e-07 241 1.31138689356065 1.2542884643579 1 3.39886360759654 496 574 571 572 241 453 417 550 382 575 574 579 M17120 GO_NUCLEAR_SPECK http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_SPECK.html A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. 232/306 Gene Ontology CC GO:0016607 0.000595457691752529 0.000720751914392124 570 528.181818181818 554 5.41471746335851e-05 433 1.33391751673825 -1.24624135835224 -1 2.24198345921219 484 580 489 570 469 574 557 570 433 530 554 580 M17684 GO_ENVELOPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENVELOPE.html A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. 1138/1396 Gene Ontology CC GO:0031975 6.18458759998506e-06 1.48481214693856e-05 570 486 554 6.18460481215819e-07 229 1.35842130754869 1.32303917853966 1 3.5518794866431 486 568 568 554 229 432 420 581 372 573 563 581 M17188 GO_NUCLEAR_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_BODY.html Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. 396/505 Gene Ontology CC GO:0016604 0.000142025220191636 0.000189258378282891 570 528.090909090909 560 1.29122172482653e-05 394 1.4006666219943 1.45103296081247 1 2.808086385046 574 578 497 567 420 552 568 560 394 533 566