Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M16044 GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 14/17 Gene Ontology BP GO:0060547 1.20716889799102e-05 0.00014889223152653 15 635.272727272727 66 1.09743229266929e-06 4 1.50423068150847 -1.56595472184924 -1 19.6718183494434 119 442 1285 66 4184 57 30 4 14 772 15 2 M13603 GO_PARTURITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARTURITION.html The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. 13/26 Gene Ontology BP GO:0007567 0.000152484488303072 0.00103321580537707 60 266.818181818182 123 1.38631871091904e-05 21 1.80424396803664 1.93260841940765 1 18.4076437606478 21 490 621 266 163 60 43 67 59 1022 123 3 M14269 GO_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 43/53 Gene Ontology BP GO:0033280 6.61637140207695e-08 1.725170415062e-06 35 810.909090909091 179 6.01488327369135e-09 34 1.79222397547385 1.77034577965832 1 35.3032613666403 34 926 158 2263 4265 42 35 179 462 69 487 4 M12234 GO_GPI_ANCHOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GPI_ANCHOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. 31/33 Gene Ontology BP GO:0006505 0.000227570031063468 0.00139265571564515 50 908.363636363636 200 2.06903249570134e-05 22 0.61514950230894 -0.623541668023183 -1 5.99630160488718 46 278 3807 187 200 22 108 120 552 4215 457 5 M10469 GO_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_PRESSURE.html Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 166/298 Gene Ontology BP GO:0008217 2.59882378245063e-12 2.15777490940541e-10 45 847 201 2.36256707495791e-13 31 1.33366740465583 1.30491397747983 1 44.0637433582449 44 2013 38 1795 1503 31 288 108 3253 201 43 6 M13529 GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN.html The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. 14/25 Gene Ontology BP GO:0032490 5.73905033738172e-05 0.000495432304635197 10 709.636363636364 216 5.21745459556071e-06 1 1.45219568015592 1.45219568015592 1 16.3986760491536 10 2335 1009 1831 216 1 31 115 1014 1146 98 7 M11939 GO_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHESION.html The attachment of a cell to the underlying substrate via adhesion molecules. 210/262 Gene Ontology BP GO:0031589 2.63888986231575e-07 5.50616795038348e-06 20 943.363636363636 232 2.3989910716813e-08 17 1.26398818029715 1.29950500553728 1 22.7168040943847 17 2514 171 2329 1384 69 514 129 2910 232 108 8 M13759 GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of a protein along a microtubule, mediated by motor proteins. 39/44 Gene Ontology BP GO:0098840 0.000497024072507012 0.00242416458005779 115 1118.54545454545 232 4.51942177936321e-05 4 0.92404589530424 -0.94884256704763 -1 8.25219682933838 143 232 3058 1259 2885 4 111 135 1097 3266 114 9 M16836 GO_INTRACILIARY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT.html The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. 39/44 Gene Ontology BP GO:0042073 0.000497024072507012 0.00242416458005779 115 1121.63636363636 233 4.51942177936321e-05 5 0.92404589530424 -0.94884256704763 -1 8.25219682933838 144 233 3059 1260 2886 5 112 158 1098 3268 115 10 M15636 GO_CELLULAR_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 52/58 Gene Ontology BP GO:0071295 1.59636050034198e-08 4.82328922603327e-07 5 1073.72727272727 239 1.45123682902315e-09 4 1.62977181538087 1.56996029948262 1 35.1864058069344 4 3041 114 2910 1907 27 75 521 2799 239 174 11 M15724 GO_LONG_CHAIN_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_TRANSPORT.html The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 37/73 Gene Ontology BP GO:0015909 0.000155857046728372 0.00104195810118838 190 527.272727272727 241 1.4169826307065e-05 60 1.15849591659236 1.15402845575542 1 11.8011450584415 189 241 1253 318 170 196 60 217 1668 1041 447 12 M14023 GO_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 140/211 Gene Ontology BP GO:0042471 3.47722681958952e-07 6.94400703500002e-06 60 1004.45454545455 243 3.16111579016854e-08 13 1.30336767707244 1.36441527072266 1 22.9758730035268 59 2539 177 1867 2740 59 225 243 2699 428 13 13 M13139 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET.html The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. 83/92 Gene Ontology BP GO:0002011 2.1683915708418e-06 3.39714679431883e-05 165 691.454545454545 246 1.9712670073473e-07 76 1.40029690959795 1.35140841294372 1 21.3843127312273 164 76 224 870 1713 246 566 2081 1280 199 187 14 M11960 GO_GLUTAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. 22/24 Gene Ontology BP GO:0006541 0.000175913292943466 0.0011404746855641 10 760.727272727273 252 1.59933964225987e-05 6 1.03549759425565 -1.09616989468173 -1 10.4081716283546 139 353 2718 498 2152 6 6 252 19 2059 166 15 M11994 GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of an acute inflammatory response. 51/97 Gene Ontology BP GO:0002673 1.03594060565184e-05 0.000131744965238532 260 1062.27272727273 257 9.41768621584372e-07 51 1.47393448837351 1.55069486042362 1 19.5431788825389 153 181 257 939 4522 206 478 51 4095 546 257 16 M16483 GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. 59/79 Gene Ontology BP GO:0006521 0.000233349915517927 0.0014174636513119 15 922.090909090909 257 2.12158791078423e-05 15 0.768787244283315 -0.654742563698473 -1 7.47642617534369 15 113 3642 330 203 127 257 710 240 3722 784 17 M14264 GO_PROTEIN_DEGLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEGLYCOSYLATION.html The removal of sugar residues from a glycosylated protein. 21/22 Gene Ontology BP GO:0006517 0.000122168143958234 0.00087794000107648 115 849.454545454545 271 1.11068116910719e-05 26 0.731025166094765 -0.792954510757405 -1 7.6286473958692 112 348 3212 114 150 271 450 321 26 4078 262 18 M16412 GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. 13/15 Gene Ontology BP GO:0048711 0.000150312556818022 0.00102853577481508 280 806.818181818182 276 1.36657116126365e-05 53 1.19226304860113 1.31205789157722 1 12.1683813858708 276 1817 2053 2150 160 137 147 127 929 1026 53 19 M15639 GO_CELLULAR_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 25/29 Gene Ontology BP GO:0071305 1.70902343630141e-06 2.73267561825101e-05 30 1001.36363636364 279 1.5536588762923e-07 13 1.76218168103255 1.75586420865494 1 27.4830107922566 27 1686 279 2755 4462 68 13 102 800 119 704 20 M16847 GO_INNER_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. 123/188 Gene Ontology BP GO:0042472 2.90233930270556e-07 6.00203767799509e-06 40 644.272727272727 285 2.63849062326848e-08 17 1.32806935648557 1.3648039982797 1 23.6989901826804 36 754 173 854 2346 17 155 285 2110 324 33 21 M12465 GO_EAR_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_DEVELOPMENT.html The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 227/339 Gene Ontology BP GO:0043583 1.24043859672667e-10 6.87114379829664e-09 50 1145.36363636364 292 1.12767145163328e-11 48 1.31786922193004 1.36434957578855 1 36.7694438898148 121 2505 59 2291 3700 48 396 292 2986 151 50 22 M14997 GO_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_RESORPTION.html Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). 33/43 Gene Ontology BP GO:0045124 2.0126659653683e-08 5.96492658398644e-07 185 736.636363636364 294 1.82969634889195e-09 97 2.16718543818673 2.27307665200741 1 46.1089475498018 184 265 117 294 3422 1068 637 97 1143 115 761 23 M11443 GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. 31/34 Gene Ontology BP GO:1901889 5.63297535910839e-05 0.00049082835853804 305 518.454545454545 295 5.12101781220125e-06 20 1.52898440357536 1.59862604843648 1 17.2875595243992 305 261 1350 295 164 1228 1492 20 100 394 94 24 M15732 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY.html Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. 16/17 Gene Ontology BP GO:0010715 1.13319080991929e-06 1.91041189802698e-05 35 344.272727272727 299 1.03017399419206e-07 7 1.6406258061204 1.70438121048411 1 26.4585023920992 31 1126 631 516 7 43 73 205 482 299 374 25 M16408 GO_REGULATION_OF_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROPTOTIC_PROCESS.html Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. 16/18 Gene Ontology BP GO:0060544 0.000256085403867127 0.00150470614121629 225 732.090909090909 305 2.32832016087126e-05 56 1.48929063743526 -1.55769810581426 -1 14.3612065823722 225 462 2015 559 2766 305 117 66 56 1403 79 26 M11855 GO_REGULATION_OF_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENERGY_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of energy homeostasis. 22/44 Gene Ontology BP GO:2000505 0.000142582198104921 0.000985787470701634 45 573.090909090909 320 1.29628581553236e-05 5 1.1303017124263 1.18676937423976 1 11.6066876027015 41 346 1321 166 791 36 5 148 1581 1549 320 27 M14078 GO_CELLULAR_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 65/74 Gene Ontology BP GO:0031670 2.67390362413133e-06 4.09265577732996e-05 15 1014.90909090909 323 2.43082443093458e-07 13 1.50971140457181 1.52117479889435 1 22.6385157930878 13 2618 228 2940 1429 38 101 461 2836 323 177 28 M16545 GO_RESPONSE_TO_HISTAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HISTAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. 2/19 Gene Ontology BP GO:0034776 5.43339387321021e-05 0.000480638435210021 565 931.5 323.5 6.03725009506797e-06 2 1.99420860703883 -1.99420860703883 -1 22.613011636983 438 563 4633 NA 113 562 49 209 2 2540 206 29 M15024 GO_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOMINERAL_TISSUE_DEVELOPMENT.html Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. 84/111 Gene Ontology BP GO:0031214 4.17697760189182e-11 2.59139690421368e-09 25 878.636363636364 325 3.79725236542831e-12 23 1.55398518818766 1.61051399800226 1 45.6091764208063 23 1492 51 2290 2648 198 325 571 1759 167 141 30 M15460 GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 15/21 Gene Ontology BP GO:0035413 3.42333866518135e-05 0.000335904000263133 310 591.818181818182 327 3.11217448695381e-06 10 1.33812561123577 1.5538091563737 1 15.8818370204201 307 1158 1667 433 427 327 88 10 172 1768 153 31 M12603 GO_RESPONSE_TO_PROSTAGLANDIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 49/107 Gene Ontology BP GO:0034694 7.45687340988477e-05 0.000599254438276232 295 1098.36363636364 335 6.77920561063825e-06 47 1.27938885933341 1.22030838556388 1 14.0845914776146 295 892 335 2789 3207 120 47 153 3019 305 920 32 M11663 GO_CYTOKINETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINETIC_PROCESS.html A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). 18/20 Gene Ontology BP GO:0032506 0.000693014487716392 0.0030681221801564 180 1074.45454545455 339 6.30211716514937e-05 11 0.863081555731572 -0.896809452841874 -1 7.40514990815204 179 1121 3293 2050 339 11 54 247 770 3592 163 33 M11799 GO_LIPID_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. 17/42 Gene Ontology BP GO:0044241 2.53527049529506e-05 0.000268715572086741 310 754.090909090909 339 2.30481792010372e-06 22 2.11396522080623 2.08621149347742 1 25.7967513316388 310 1119 285 296 3873 168 22 375 781 727 339 34 M10947 GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 248/324 Gene Ontology BP GO:0031668 8.43578944151228e-07 1.48680788906654e-05 340 902.727272727273 340 7.66890243288644e-08 2 1.36749154999683 1.33046531459326 1 22.5608883345353 172 2500 202 1865 998 2 340 592 2686 339 234 35 M12239 GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. 18/18 Gene Ontology BP GO:0042982 0.000702132825449182 0.00309122433779457 100 662.818181818182 348 6.38506374743508e-05 18 1.9316889582604 -1.9316889582604 -1 16.5653759298821 97 1751 1491 348 1428 18 191 143 500 1184 140 36 M14703 GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. 5/18 Gene Ontology BP GO:0045653 0.000666615973125956 0.00299109365762302 560 927.909090909091 348 6.66816027176994e-05 141 1.32676798269492 -1.55253743027136 -1 11.4393507525453 560 555 4513 174 348 1086 235 167 141 2236 192 37 M15439 GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 13/19 Gene Ontology BP GO:0050746 0.000308617717744268 0.00174060392807767 1480 658.090909090909 354 2.80600926711874e-05 33 2.37567372609153 2.83178110071845 1 22.4012095435957 1476 501 1181 354 232 794 277 88 33 2105 198 38 M10293 GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of adipocyte differentiation. 114/139 Gene Ontology BP GO:0045598 0.0001222663057592 0.00087794000107648 240 710.909090909091 361 1.11157364827682e-05 31 1.22021950632975 1.23259021044471 1 12.7407932609328 240 31 361 1820 1545 157 451 334 2036 600 245 39 M16514 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 39/77 Gene Ontology BP GO:1903556 0.000787399805180474 0.00335817717094844 135 453.090909090909 361 7.16074330864666e-05 132 1.30101194649859 1.45926069535004 1 10.9934545115696 132 930 607 144 361 438 243 203 1157 536 233 40 M14836 GO_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 130/167 Gene Ontology BP GO:0033273 3.07125344089821e-10 1.48859815213535e-08 65 872.454545454545 371 2.79204858302451e-11 63 1.49541975157928 1.4561669128131 1 40.0080587959141 63 1441 69 2338 2253 175 195 799 1754 139 371 41 M13198 GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 21/28 Gene Ontology BP GO:0009218 0.0010899361946715 0.00421996384899269 205 1572.72727272727 372 9.91342319753759e-05 50 0.890057737361806 -0.890057737361806 -1 7.21566663212455 202 3154 3475 2092 3980 50 115 189 372 3376 295 42 M12893 GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT.html The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 21/44 Gene Ontology BP GO:0015697 1.42509351952145e-05 0.000171786532288428 355 820 373 1.29554795539122e-06 36 0.884665786073831 0.896937536747579 1 11.3770862260211 897 373 2603 353 36 682 353 110 207 2428 978 43 M11866 GO_AMINO_ACID_BETAINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_TRANSPORT.html The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/40 Gene Ontology BP GO:0015838 1.65804795499691e-05 0.000192177200865618 45 749.818181818182 374 1.50732768285681e-06 41 0.884665786073831 0.896937536747579 1 11.2297483857258 891 374 2547 333 43 476 160 41 125 2352 906 44 M10971 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 41/75 Gene Ontology BP GO:0071379 0.000143002094353418 0.000987086469488264 355 1244.45454545455 377 1.30010354974233e-05 46 1.26243088221255 1.26205816347492 1 12.9622555441998 352 933 377 2830 4313 129 56 46 3426 373 854 45 M14169 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. 18/21 Gene Ontology BP GO:0045986 1.6603317160537e-05 0.000192177200865618 760 506.909090909091 377 1.50940386058821e-06 44 1.53935366606258 1.34983279319931 1 19.5480998397178 760 407 313 91 44 77 377 1466 509 272 1260 46 M10729 GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 351/467 Gene Ontology BP GO:0071496 7.06808652694822e-08 1.82710036721611e-06 265 1046.27272727273 378 6.42553341275395e-09 9 1.29804090090358 1.32464546265331 1 25.4552543405982 265 2949 134 2427 1654 9 503 238 2861 378 91 47 M11323 GO_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATRIX_ADHESION.html The binding of a cell to the extracellular matrix via adhesion molecules. 145/186 Gene Ontology BP GO:0007160 1.8964887548358e-07 4.14289304049341e-06 165 1074.45454545455 381 1.72408083483709e-08 16 1.33444483517682 1.36923754833654 1 24.5473328670495 16 2542 161 3208 1115 381 673 163 3049 245 266 48 M14474 GO_DETECTION_OF_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_ABIOTIC_STIMULUS.html The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. 128/227 Gene Ontology BP GO:0009582 6.75281085103437e-07 1.24685828928028e-05 60 588.818181818182 384 6.13892083980291e-08 4 1.34274554906965 1.32595592656976 1 22.503344291504 94 4 193 542 756 56 821 1415 2152 384 60 49 M13731 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of phagocytosis. 65/79 Gene Ontology BP GO:0050766 0.000182354999239786 0.00116872976785499 485 515.272727272727 385 1.65791014682911e-05 70 1.25425111783128 1.32612001244929 1 12.5636201013087 484 107 385 70 241 153 1090 354 1665 491 628 50 M10499 GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the rate of skeletal muscle tissue development. 27/40 Gene Ontology BP GO:0048643 0.00030162791788341 0.00171334783897087 465 714.454545454545 389 2.74244800087283e-05 14 1.12571522922909 1.16336978216133 1 10.6356050379621 464 312 2090 426 831 155 34 211 389 2933 14 51 M14054 GO_VITAMIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORT.html The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 31/42 Gene Ontology BP GO:0051180 0.000101023644882768 0.00075210083142323 1895 1199.81818181818 395 9.1843894700442e-06 33 1.61145195811171 -1.70925458619253 -1 17.1993988393687 1893 266 354 33 3078 2147 3283 264 161 395 1324 52 M11006 GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. 14/18 Gene Ontology BP GO:0009208 0.000993634086882985 0.0039549866606215 165 1076.63636363636 398 9.0371195230595e-05 82 0.823121694810678 -0.823121694810678 -1 6.75147519834204 161 1796 3328 1524 545 121 355 178 82 3355 398 53 M11628 GO_MEMBRANE_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. 20/24 Gene Ontology BP GO:0046466 0.00104765348149662 0.00410657295897451 465 884.272727272727 402 9.52866103062168e-05 187 1.26676790032027 1.41941580107934 1 10.3253878988168 465 402 2434 206 2634 253 328 187 591 1842 385 54 M10246 GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. 108/204 Gene Ontology BP GO:1900544 2.69836783217739e-05 0.000281513576751601 320 642.090909090909 404 2.45309175369014e-06 38 1.23683080214868 1.16532506834816 1 15.0031953477129 320 38 288 804 1032 146 426 404 2827 568 210 55 M14475 GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 11/15 Gene Ontology BP GO:0009312 0.000807700700132435 0.0034111851761443 190 977.454545454545 406 7.34543081085679e-05 80 1.95335193641622 1.92254133899329 1 16.4656010090766 186 2890 1162 1754 3117 95 80 154 111 797 406 56 M13389 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 24/54 Gene Ontology BP GO:0030813 0.000253430727729577 0.00149456676315047 70 738.181818181818 408 2.30418115082194e-05 8 1.12790941811731 1.1926038691146 1 10.8851491544215 68 356 2017 444 1865 163 8 138 873 1780 408 57 M10296 GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that modulates the frequency, rate or extent of protein activation cascade. 28/46 Gene Ontology BP GO:2000257 0.000103765831808432 0.000768825502236682 55 929.272727272727 411 9.43370239824191e-06 17 1.4989438448558 1.66009845468343 1 15.9488786090633 55 1654 411 943 1657 159 151 33 3810 1332 17 58 M15520 GO_RESPONSE_TO_ACIDIC_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACIDIC_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. 18/28 Gene Ontology BP GO:0010447 3.979450906843e-06 5.73262695651407e-05 1315 670.181818181818 412 3.61768918641497e-07 17 1.29823123306026 -1.1960698404843 -1 18.8162419104661 1314 409 1143 724 17 495 354 150 412 2138 216 59 M16158 GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. 98/126 Gene Ontology BP GO:0046467 0.00109620567137642 0.00422588648625888 375 597.090909090909 414 9.97047513568697e-05 16 1.10442066883141 -0.953929045496027 -1 8.95376745310803 371 45 2287 50 441 16 414 847 502 1302 293 60 M14611 GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. 26/28 Gene Ontology BP GO:0031146 1.96745332092213e-05 0.000221660055744568 545 802.727272727273 415 1.78860992365249e-06 43 0.88308535787573 -0.93551496422013 -1 11.0225195033934 541 297 2900 61 50 415 808 606 43 2844 265 61 M15563 GO_CAMP_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 11/14 Gene Ontology BP GO:0006198 0.000152520714846358 0.00103321580537707 275 744.181818181818 415 1.38664808879557e-05 49 1.69135960531209 1.47386600411605 1 17.2552836429244 274 2870 1176 1223 377 319 415 49 244 799 440 62 M13990 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. 76/106 Gene Ontology BP GO:0042590 0.00021267316540699 0.00132472321102908 90 1090.18181818182 417 1.93357933840044e-05 79 0.825397587508158 -0.629442767073368 -1 8.11067397151619 86 95 3422 1073 193 79 296 560 1688 4083 417 63 M16308 GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 40/46 Gene Ontology BP GO:0060444 6.36424852129278e-05 0.000536464644376364 4475 1440.63636363636 417 5.78584785117404e-06 108 1.44812414601163 -1.56643648448731 -1 16.1815763188702 4473 204 417 210 108 4339 4332 502 273 356 633 64 M14131 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. 18/23 Gene Ontology BP GO:1903019 0.000284516056913082 0.00164785700355783 940 804.636363636364 418 2.58684417047438e-05 71 1.26141048783036 1.47105838192935 1 11.9919175417584 938 418 1599 101 315 432 200 71 2944 1602 231 65 M10185 GO_ANTEROGRADE_AXONAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_AXONAL_TRANSPORT.html The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. 27/32 Gene Ontology BP GO:0008089 0.000405859378257177 0.00209364045125348 335 1255.27272727273 423 3.69031155601926e-05 38 1.0087850173854 -1.0087850173854 -1 9.22950008773244 332 2737 3534 1594 423 219 38 94 1121 3655 61 66 M14842 GO_THALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THALAMUS_DEVELOPMENT.html The process in which the thalamus changes over time, from its initial formation to its mature state. 17/31 Gene Ontology BP GO:0021794 0.000238329194944221 0.0014407409156256 425 660.545454545455 423 2.16686379462224e-05 9 1.41201993346368 -1.36557346602444 -1 13.7066101168984 644 423 1288 191 1279 55 759 421 156 2041 9 67 M12996 GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS.html The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. 14/15 Gene Ontology BP GO:0019184 3.72818366210315e-06 5.45510647162452e-05 130 449.363636363636 424 3.38926361818733e-07 14 1.3271194879985 -1.09121950402627 -1 19.3329603601669 126 456 859 42 14 58 81 1126 613 1144 424 68 M10790 GO_INDOLALKYLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLALKYLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. 8/18 Gene Ontology BP GO:0006586 0.000106753207004119 0.000787199163534334 430 1355.09090909091 426 1.06758335662115e-05 37 2.6635115355741 -2.6635115355741 -1 28.2548502136058 426 3941 4262 2557 187 260 52 37 869 2015 300 69 M13998 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 108/204 Gene Ontology BP GO:0045981 2.69836783217739e-05 0.000281513576751601 570 658 427 2.45309175369014e-06 39 1.23683080214868 1.16532506834816 1 15.0031953477129 321 39 289 805 1033 147 427 569 2828 569 211 70 M14536 GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/28 Gene Ontology BP GO:0010829 0.00367420012029144 0.0101592463568013 340 753.454545454545 427 0.000334577341317299 146 1.08808863226736 1.07239023102277 1 7.40404726507528 283 338 1465 427 938 734 336 370 989 2262 146 71 M16326 GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. 17/22 Gene Ontology BP GO:2000479 0.000178978344402603 0.00115184818327152 1835 758.090909090909 430 1.62720824207605e-05 61 1.51808974761551 1.5795751007593 1 15.2414863470254 1832 430 1705 813 185 386 280 289 61 1054 1304 72 M11397 GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 46/67 Gene Ontology BP GO:0009187 6.88560512177913e-05 0.00056994870683588 410 1106.36363636364 433 6.25983694391265e-06 286 1.34253345512218 1.29965603721736 1 14.8802172999245 286 2153 327 1715 2785 410 381 433 2204 407 1069 73 M10118 GO_ACYLGLYCEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. 19/41 Gene Ontology BP GO:0055090 7.05454035676002e-05 0.000576885347627494 120 791.818181818182 434 6.41342416223599e-06 119 1.40490954236239 1.16870807538757 1 15.5468342490725 2018 378 1308 287 119 434 830 224 120 882 2110 74 M11593 GO_TRIGLYCERIDE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. 19/41 Gene Ontology BP GO:0070328 7.05454035676002e-05 0.000576885347627494 2020 801.727272727273 435 6.41342416223599e-06 120 1.40490954236239 1.16870807538757 1 15.5468342490725 2019 379 1309 288 120 435 831 320 121 886 2111 75 M13074 GO_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_B_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. 46/57 Gene Ontology BP GO:0043491 0.00403243851712401 0.0108524862319725 80 825.181818181818 441 0.000367258973016654 78 0.996779364550547 1.04883631273926 1 6.68412826438366 78 185 2312 441 1589 118 123 581 909 2332 409 76 M14058 GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of ATP metabolic process. 31/63 Gene Ontology BP GO:1903580 0.000301098722778011 0.00171272904289252 315 676.454545454545 443 2.73763581788255e-05 27 1.07264062578738 1.16486034105268 1 10.1342359738983 312 277 2057 443 228 746 27 408 717 1568 658 77 M11573 GO_OVULATION_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE.html The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 107/155 Gene Ontology BP GO:0042698 0.000115585116667272 0.000840339918520025 365 1157.09090909091 445 1.05082899822295e-05 339 1.38423837493061 1.24054443654157 1 14.5447789417611 363 2570 358 3033 1691 355 339 445 2303 400 871 78 M13378 GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION.html Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 16/24 Gene Ontology BP GO:0010935 5.8045406803875e-05 0.000500157921960056 320 621 446 5.27699439513369e-06 202 1.43814303652823 1.44719573450731 1 16.2196140557491 318 446 404 818 369 1246 778 291 1343 202 616 79 M15609 GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. 16/18 Gene Ontology BP GO:0051044 0.000224228210862707 0.00137642990124562 1370 625.545454545455 449 2.03864607175172e-05 44 1.38064083875644 -1.31088405703308 -1 13.4953861067279 1367 449 1829 73 198 401 140 459 44 961 960 80 M15637 GO_PEPTIDE_HORMONE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_PROCESSING.html The generation of a mature peptide hormone by posttranslational processing of a prohormone. 18/44 Gene Ontology BP GO:0016486 2.2712876259902e-05 0.000245774449389126 230 1023.54545454545 449 2.06482825016483e-06 59 1.33450371089863 1.45981847051701 1 16.4578670348915 227 3160 1584 2257 59 342 449 152 582 2139 308 81 M16378 GO_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 268/370 Gene Ontology BP GO:0009612 4.74882493933589e-08 1.31525490730535e-06 385 1090.81818181818 452 4.3171136744018e-09 124 1.27397923301075 1.36143949148175 1 25.6049772948826 385 2497 124 1384 2830 428 723 452 2454 431 291 82 M12884 GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. 52/73 Gene Ontology BP GO:0019935 0.000586555877923344 0.00273197647645377 140 914.090909090909 459 5.33374837894358e-05 137 1.31183315837744 1.33727658432735 1 11.4869650957021 137 174 459 350 2650 620 432 418 2904 730 1181 83 M10687 GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. 40/54 Gene Ontology BP GO:0045599 0.00544228279871554 0.0134173121734632 520 862 462 0.000495981139820629 210 1.24020892664807 1.12250399491906 1 7.92842687380952 516 228 854 389 3222 291 210 462 1893 973 444 84 M14629 GO_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of B cell proliferation. 56/96 Gene Ontology BP GO:0030888 0.00193023236590695 0.00637881477170813 470 1083.27272727273 469 0.0001756298175588 144 1.22218135205007 1.22684205569915 1 9.16239307287321 469 144 691 334 3862 388 238 265 3030 719 1776 85 M11353 GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cell junction assembly. 116/135 Gene Ontology BP GO:1901888 0.000538720071133477 0.00255261149794712 70 765.909090909091 471 4.89865485678187e-05 20 1.22021113223276 1.23990489963113 1 10.8069760439377 67 20 471 901 2589 124 512 114 2941 640 46 86 M15925 GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. 22/30 Gene Ontology BP GO:1902170 0.00109459894882794 0.00422319146674661 380 1163.36363636364 475 9.95585400632204e-05 44 0.890892310766355 0.902221527497994 1 7.22143111912427 380 366 2328 1092 639 344 44 223 3917 2989 475 87 M12679 GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary amino compound. 14/25 Gene Ontology BP GO:1901160 0.000197293602026976 0.00125239717630494 2155 760.909090909091 478 1.79373906658047e-05 29 1.75024832719648 -1.88671237880822 -1 17.3564687844389 2154 478 746 265 561 1040 2559 55 29 340 143 88 M10632 GO_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 70/93 Gene Ontology BP GO:0061035 2.40212582935935e-06 3.72569716133635e-05 340 982.818181818182 480 2.18375313835037e-07 123 1.30685380559905 1.40196338503087 1 19.7774671236937 337 837 286 1007 4550 480 1145 353 1463 123 230 89 M11240 GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION.html The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. 13/14 Gene Ontology BP GO:0036508 0.000738879609675771 0.00320410701194908 365 1011.54545454545 484 6.71934438513481e-05 27 0.801853868096117 -0.89168528912338 -1 6.82743196683684 361 484 2947 150 350 969 1028 676 27 3807 328 90 M15430 GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION.html The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. 405/616 Gene Ontology BP GO:0048667 8.50926422744422e-09 2.69344261566653e-07 325 1289.09090909091 484 7.73569478214249e-10 109 1.30400653469534 1.33319483735417 1 29.2791916194478 324 2471 109 2304 4037 188 484 1531 1852 413 467 91 M12900 GO_PROTEIN_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMANNOSYLATION.html The removal of one or more mannose residues from a mannosylated protein. 13/14 Gene Ontology BP GO:0036507 0.000738879609675771 0.00320410701194908 365 1012.09090909091 485 6.71934438513481e-05 28 0.801853868096117 -0.89168528912338 -1 6.82743196683684 362 485 2948 151 351 970 1029 669 28 3811 329 92 M15684 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. 14/30 Gene Ontology BP GO:0060850 0.000746413687216598 0.00322176520094511 1680 1175.54545454545 488 6.78788227291653e-05 17 1.19913675898345 1.43479587250662 1 10.205617770511 1676 488 1788 323 353 2792 3656 288 17 1150 400 93 M13729 GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. 11/24 Gene Ontology BP GO:0042753 3.91544269101459e-06 5.67556225585385e-05 1625 830.727272727273 497 3.55949969048006e-07 16 1.23414154513553 1.5479387840645 1 17.9051481505757 1623 497 1741 291 16 371 633 448 154 2477 887 94 M13488 GO_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BROWN_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 34/40 Gene Ontology BP GO:0050873 6.30857893211127e-05 0.000534677919328119 170 929.090909090909 498 5.73523621830749e-06 32 1.41621306138597 1.26785596641479 1 15.8317769673085 169 2208 793 3197 107 32 105 918 1966 498 227 95 M12822 GO_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 209/316 Gene Ontology BP GO:1901654 3.42507553238954e-06 5.09165381859697e-05 335 1108.36363636364 499 3.11370987703511e-07 192 1.22869344879535 1.24608875399364 1 18.0241287380321 331 1388 233 2313 3383 214 407 499 2609 192 623 96 M14110 GO_BLOOD_VESSEL_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_REMODELING.html The reorganization or renovation of existing blood vessels. 34/45 Gene Ontology BP GO:0001974 0.000371826235653097 0.00197275652735902 220 1353.09090909091 499 3.38080994177093e-05 87 1.47225581716706 1.54391886829953 1 13.604761137988 217 2700 556 2056 4276 437 97 87 3661 499 298 97 M14080 GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 45/58 Gene Ontology BP GO:0010828 0.00361950177396637 0.0100486525980105 505 803.909090909091 501 0.000329588221106833 104 1.07246652020965 1.32238646538777 1 7.3150216630899 501 199 1195 2349 643 104 334 377 1956 1015 170 98 M13816 GO_NEGATIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BEHAVIOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 7/21 Gene Ontology BP GO:0048521 3.40539758667979e-05 0.000335904000263133 125 1147.72727272727 502 3.40544977310257e-06 1 1.79245903036245 1.79245903036245 1 21.2778130726335 124 1864 4451 2799 321 20 1 136 599 1808 502 99 M14492 GO_TRACHEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_MORPHOGENESIS.html The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. 15/21 Gene Ontology BP GO:0060439 0.00199636449058498 0.00650951925346315 1200 1266.27272727273 504 0.000181652579381258 64 1.02480476119318 -0.861090177756767 -1 7.6501230212343 1199 1783 2684 240 3850 133 504 299 258 2915 64 100 M15950 GO_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 226/310 Gene Ontology BP GO:0007584 1.62929319662004e-11 1.13150764833926e-09 115 942.454545454545 505 1.48117563330192e-12 47 1.42334309706452 1.45707640618153 1 43.525238303104 113 2506 47 2268 1134 378 505 458 2015 131 812 101 M11109 GO_IMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving IMP, inosine monophosphate. 13/14 Gene Ontology BP GO:0046040 2.06661862724743e-05 0.000229498245169028 5 1633.81818181818 507 1.87876185521964e-06 2 0.746410479241851 -0.746410479241851 -1 9.27640323969551 216 507 3337 2112 4239 3 2 8 3657 3806 85 102 M15276 GO_SENSORY_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_MORPHOGENESIS.html Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 265/407 Gene Ontology BP GO:0090596 3.57877942904577e-11 2.25027847072297e-09 235 1004.09090909091 507 3.25343584463998e-12 50 1.24511659715834 1.26142226349077 1 36.8027648264544 235 2489 50 1237 2239 86 507 1496 2348 230 128 103 M10565 GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS.html The process in which the left cardiac ventricle is generated and organized. 12/18 Gene Ontology BP GO:0003214 0.000348158919175421 0.00188809260014363 490 1173 508 3.16558208132859e-05 46 1.56122862915371 1.56122862915371 1 14.5292671904353 489 3573 2269 2221 733 273 137 80 46 2574 508 104 M10616 GO_RESPONSE_TO_PROSTAGLANDIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 38/86 Gene Ontology BP GO:0034695 0.00012307706786308 0.000879689088735655 120 912.363636363636 508 1.11894503491707e-05 36 1.19006773967725 1.26619922370237 1 12.4221863692385 117 244 625 2809 2468 116 36 40 2564 508 509 105 M11711 GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 14/17 Gene Ontology BP GO:0009214 9.82066859178356e-05 0.000735838501732189 625 551.818181818182 509 8.92827909814787e-06 32 1.69141042226802 1.57501853263177 1 18.1082428372278 623 1148 904 283 190 1027 762 32 138 509 454 106 M10338 GO_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT.html Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 73/89 Gene Ontology BP GO:0046324 0.00251346955615508 0.00765784660621833 490 1217.27272727273 511 0.000228758705620832 81 0.971440595136775 1.1074174423279 1 7.01686285767929 487 98 1668 1342 4552 160 511 430 1992 2069 81 107 M10250 GO_FATTY_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 76/95 Gene Ontology BP GO:0009062 0.000327604304350315 0.00181902485458475 515 979.909090909091 513 2.97866453111899e-05 62 0.948058346848459 -0.958299135765711 -1 8.87119110165569 513 86 3214 62 239 279 972 384 719 3219 1092 108 M11066 GO_RESPONSE_TO_PHENYLPROPANOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PHENYLPROPANOID.html Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. 10/17 Gene Ontology BP GO:0080184 4.52410638221771e-05 0.000416021086886542 930 762.636363636364 513 4.11290856287492e-06 183 1.95838204449016 1.78220049066536 1 22.6264060176779 927 513 308 268 291 1445 646 2628 183 418 762 109 M13395 GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 18/24 Gene Ontology BP GO:0071872 0.000373201595039873 0.00197779843020561 235 875.636363636364 515 3.39331744464868e-05 234 1.19722988875354 1.3064597557822 1 11.0567834196723 234 421 2083 1862 259 515 359 456 641 1600 1202 110 M12625 GO_COBALAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COBALAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. 19/42 Gene Ontology BP GO:0009235 0.000587862919197341 0.00273532616302523 220 1109.36363636364 517 5.34563691893337e-05 124 1.1708995810732 -1.25601008134153 -1 10.249615272428 220 1105 2497 517 2907 511 1556 124 295 2247 224 111 M11877 GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 54/72 Gene Ontology BP GO:0009064 0.00199060415931802 0.00649984642337316 520 1065.63636363636 519 0.000181127962074068 35 1.26189532163218 -1.23122120384817 -1 9.4252468976364 519 872 1310 486 4430 35 500 400 1766 1027 377 112 M11944 GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION.html The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. 9/13 Gene Ontology BP GO:0017187 5.94723666532275e-05 0.000509622324194232 550 883.363636363636 522 5.94739583462583e-06 5 2.09190423025088 1.78098351443217 1 23.5394602059947 546 522 4334 272 1554 1269 321 22 5 558 314 113 M13040 GO_PROTEIN_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CARBOXYLATION.html The addition of a carboxy group to a protein amino acid. 9/13 Gene Ontology BP GO:0018214 7.63313069732943e-05 0.000609210242447236 550 891.090909090909 523 7.63339290108436e-06 6 2.09190423025088 1.78098351443217 1 22.985037525243 547 523 4403 273 1555 1270 322 29 6 559 315 114 M14708 GO_GLUTATHIONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. 53/71 Gene Ontology BP GO:0006749 0.00211561216052813 0.00676559682676109 210 460.909090909091 526 0.00019251357863826 19 1.26388429601534 -1.09691844489351 -1 9.36491846988431 206 133 724 19 526 98 619 907 257 785 796 115 M16619 GO_NUCLEOTIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SALVAGE.html Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. 12/14 Gene Ontology BP GO:0043173 0.000107204754983716 0.00078927804578992 30 1215.27272727273 528 9.74636176065222e-06 4 1.01357496619449 -1.01357496619449 -1 10.7415506066585 367 528 2894 2015 1448 29 4 34 2815 3204 30 116 M12687 GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE.html The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. 10/60 Gene Ontology BP GO:0050912 5.31171303808384e-05 0.00047347511046368 110 917.454545454545 530 4.82894662656022e-06 16 1.72685931298047 1.72177248020462 1 19.6185195971131 109 1847 907 1974 3479 64 39 16 530 1082 45 117 M13687 GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 490/679 Gene Ontology BP GO:0009991 2.35960013861945e-12 2.03318878611043e-10 375 905.363636363636 530 2.1450910351109e-13 34 1.33876709883381 1.33556909424425 1 44.3504968653307 373 1917 37 2255 1044 34 530 1054 2260 82 373 118 M13549 GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. 37/70 Gene Ontology BP GO:0071622 0.00024063316983124 0.00144659707910176 405 1058 531 2.18781358189919e-05 104 1.57916658261935 1.65888492014298 1 15.3208689918453 405 2190 406 531 4431 442 652 959 1037 481 104 119 M16538 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. 89/230 Gene Ontology BP GO:0007187 1.35611570913742e-06 2.20629594217358e-05 535 950.636363636364 531 1.2328332227908e-07 70 1.37676448323911 1.23918396324679 1 21.9071092153674 531 70 216 2253 2747 125 570 1290 2073 381 201 120 M10425 GO_B_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 24/28 Gene Ontology BP GO:0001782 0.00069000352401976 0.00306061620330214 535 996.272727272727 534 6.27472754903298e-05 61 0.992852346023293 0.965665587931634 1 8.52378400535247 534 1022 2404 439 1773 945 61 142 507 2682 450 121 M10423 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN.html The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. 10/27 Gene Ontology BP GO:0001991 6.97249512594283e-06 9.43111041308488e-05 620 730 535 6.33865202189183e-07 21 1.47973079514085 1.77164516659412 1 20.3545139140809 618 535 1358 300 21 1544 1133 149 309 1644 419 122 M13063 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. 12/30 Gene Ontology BP GO:0002532 0.0159481654133777 0.0297195721562134 455 1196.72727272727 535 0.00146045121908083 323 1.26889037431397 0.827843961467736 1 6.61369006479385 452 503 1227 397 3818 463 323 2155 535 1959 1332 123 M11082 GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC.html The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine. 10/32 Gene Ontology BP GO:0007271 5.17076507260883e-05 0.000464470461058859 570 578.090909090909 536 4.70080600688092e-06 9 1.5661612499263 1.51954018387212 1 17.8365197644703 566 536 1303 343 1224 930 9 13 107 1077 251 124 M11841 GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 12/17 Gene Ontology BP GO:0060218 0.00220739406104319 0.00696339292612474 1845 897.909090909091 536 0.000200873817289002 105 0.990794608403331 1.01440153253576 1 7.29672673403093 1845 492 1691 301 536 1513 687 429 324 1954 105 125 M16175 GO_IMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. 10/11 Gene Ontology BP GO:0006188 0.000155538815005382 0.00104132677153963 355 1410.18181818182 537 1.41408920549431e-05 50 0.75197597794327 -0.75197597794327 -1 7.65702049363054 351 537 3177 2533 810 162 55 50 3806 3627 404 126 M10047 GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. 9/18 Gene Ontology BP GO:0036150 0.000505830058462589 0.00244281757775238 750 943.454545454545 538 5.05945234183503e-05 47 1.55798812759251 -1.65724750113886 -1 13.9032043456545 747 538 4219 47 398 1474 1091 119 521 930 294 127 M10996 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. 43/51 Gene Ontology BP GO:1900077 0.00157308957877244 0.0055377536451456 115 1062.09090909091 540 0.000143110502652327 90 1.07519562776939 1.04684334603479 1 8.2849269526779 114 931 2315 3305 540 90 98 227 1600 2144 319 128 M11214 GO_RESPONSE_TO_POTASSIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_POTASSIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. 10/20 Gene Ontology BP GO:0035864 1.2951172333923e-05 0.000157341527075049 170 1454.90909090909 542 1.17738623425115e-06 5 1.5895757148965 1.5895757148965 1 20.658260338541 167 2905 1650 3236 542 372 213 5 3833 3014 67 129 M10163 GO_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 97/235 Gene Ontology BP GO:0007586 1.50107039247337e-10 8.12148899555651e-09 85 1273.27272727273 545 1.36460944779617e-11 61 1.60048382511727 1.54186887017242 1 44.2595680788045 85 2578 61 2259 4541 84 110 1198 2415 130 545 130 M11222 GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. 28/31 Gene Ontology BP GO:1903392 7.00848186619431e-05 0.000575140496003564 1710 1312.72727272727 545 6.37155013046115e-06 23 1.56184806572961 1.77775666182641 1 17.2917437426757 1709 292 1526 309 4479 2670 2738 23 112 545 37 131 M13501 GO_POSITIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_RESORPTION.html Any process that activates or increases the frequency, rate or extent of bone resorption. 11/15 Gene Ontology BP GO:0045780 0.000671716195547554 0.00300239717375867 610 700.909090909091 546 6.10837613973314e-05 153 2.03300402685732 2.24467177262255 1 17.5227846901561 610 525 546 721 579 801 153 351 2712 316 396 132 M14984 GO_POSITIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_REMODELING.html Any process that activates or increases the frequency, rate or extent of bone remodeling. 11/15 Gene Ontology BP GO:0046852 0.000671716195547554 0.00300239717375867 615 699.636363636364 547 6.10837613973314e-05 154 2.03300402685732 2.24467177262255 1 17.5227846901561 611 526 547 722 580 802 154 327 2713 317 397 133 M14879 GO_CELLULAR_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 156/199 Gene Ontology BP GO:0097306 8.3235006927306e-07 1.47259500848956e-05 445 905.909090909091 548 7.56682167441214e-08 201 1.31885165877196 1.39283193232623 1 21.7768574896128 441 730 201 548 2984 399 510 731 2135 261 1025 134 M11779 GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 31/63 Gene Ontology BP GO:0045979 0.000301098722778011 0.00171272904289252 315 688.363636363636 550 2.73763581788255e-05 26 1.07264062578738 1.16486034105268 1 10.1342359738983 311 276 2056 442 227 745 26 550 716 1566 657 135 M10302 GO_MAMMARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_MORPHOGENESIS.html The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 65/77 Gene Ontology BP GO:0060443 3.94487789409311e-06 5.70047106870039e-05 3590 1334.09090909091 551 3.58625906161385e-07 115 1.45438017236666 -1.58296174647599 -1 21.0928558261712 3589 115 238 225 1612 2498 4605 420 657 165 551 136 M16432 GO_TEMPERATURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TEMPERATURE_HOMEOSTASIS.html A homeostatic process in which an organism modulates its internal body temperature. 22/35 Gene Ontology BP GO:0001659 2.06569459604389e-05 0.000229498245169028 555 757.545454545455 553 1.87792181107403e-06 53 1.16692899020615 1.12467952367018 1 14.5086223258345 553 381 1646 1009 53 447 58 1338 253 1554 1041 137 M13964 GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. 18/36 Gene Ontology BP GO:0042430 0.00140249585481327 0.00508240904396116 2085 917 555 0.000127580976551325 204 1.95825124027129 -2.03809559109342 -1 15.3475635156066 2081 451 825 328 2996 724 1416 214 293 555 204 138 M10758 GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 102/128 Gene Ontology BP GO:0006661 0.00151913954775736 0.00537941880952436 730 1014.18181818182 565 0.000138199050557577 26 0.8425663821292 -0.868638489998969 -1 6.52638551250857 730 41 3670 180 723 26 565 708 505 3765 243 139 M15401 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 7/13 Gene Ontology BP GO:0034374 0.000484387097308145 0.00237748224026878 2215 1163.27272727273 567 4.84492713597408e-05 113 2.08095696268467 -2.16362940464419 -1 18.6574293504611 2212 551 4552 510 837 1485 1324 113 281 364 567 140 M15290 GO_RESPONSE_TO_EPINEPHRINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPINEPHRINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 23/29 Gene Ontology BP GO:0071871 0.0028001570237379 0.00830939453536508 140 737.181818181818 572 0.000254884311235602 88 1.17571579722463 1.25124404751294 1 8.35206595856856 140 360 2157 1406 572 88 134 335 759 1277 881 141 M11096 GO_ALDEHYDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. 16/18 Gene Ontology BP GO:0046185 0.000631061991158406 0.00288441202834977 100 882.545454545455 573 5.73857347018793e-05 98 0.955623534805603 -0.955623534805603 -1 8.28790557563353 98 1125 2536 544 487 396 707 133 667 2442 573 142 M15240 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. 15/24 Gene Ontology BP GO:0061081 0.00105435969208636 0.00412610231057848 190 991 573 9.5896848901135e-05 83 1.44398755047546 1.36116300936927 1 11.7612194932125 83 1790 638 1871 2833 229 172 188 2338 573 186 143 M14615 GO_MUSCLE_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_FATE_COMMITMENT.html The process in which the cellular identity of muscle cells is acquired and determined. 5/19 Gene Ontology BP GO:0042693 0.000148301365636117 0.00101776733673282 2720 1451.27272727273 576 1.48311263548555e-05 83 1.66749288246272 -2.03098944864467 -1 17.0489438464443 2719 2922 4504 557 180 576 529 83 464 2235 1195 144 M12633 GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 12/15 Gene Ontology BP GO:0006244 0.000517752171373051 0.00247839343579131 290 1115.18181818182 581 4.7079460028405e-05 288 0.908782088176399 -0.908782088176399 -1 8.08585391690031 288 511 3199 581 304 391 300 1313 956 3194 1230 145 M16590 GO_AZOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AZOLE_TRANSPORT.html The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/15 Gene Ontology BP GO:0045117 3.28695084530914e-06 4.90198150103315e-05 745 757.545454545455 583 2.98814159659032e-07 13 1.57516347690364 1.36864744174367 1 23.1984141833161 742 505 917 282 13 583 454 1559 58 1806 1414 146 M10918 GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL.html Any virus-mediated process that modulates the levels of viral proteins in a cell. 15/18 Gene Ontology BP GO:0046719 3.16832318561615e-05 0.000318406215608465 960 989.818181818182 587 2.88033528640396e-06 72 0.868131878062694 -0.851677505808343 -1 10.3688280103724 957 1141 3152 587 72 350 216 974 409 2903 127 147 M12319 GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neutrophil migration. 23/50 Gene Ontology BP GO:1902624 0.00229109554960329 0.00716911068749437 485 815.909090909091 587 0.000208498636106474 431 1.66861476730685 1.61583367727644 1 12.223706412774 916 1036 587 483 2311 501 560 991 431 482 677 148 M13499 GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 29/37 Gene Ontology BP GO:0061037 0.000916286544701694 0.00372681931162324 495 1083.81818181818 590 8.33334904650705e-05 92 1.305452291647 1.42410698501211 1 10.8291165452843 494 2710 635 2129 1356 178 479 168 3091 590 92 149 M13286 GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 85/104 Gene Ontology BP GO:0042158 0.000718402560366255 0.0031475773195708 595 1476.45454545455 591 6.53306599633002e-05 25 0.746342301673621 -0.718892676726559 -1 6.37376351969895 591 809 3817 521 343 25 358 2058 3438 4170 111 150 M13430 GO_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_MIGRATION.html Any process that modulates the frequency, rate or extent of neuron migration. 68/79 Gene Ontology BP GO:2001222 0.00192892008974562 0.00637881477170813 25 868.545454545455 591 0.000175510310072276 24 1.30468334532471 1.45514052597286 1 9.78161000613149 24 847 591 1433 801 70 135 368 3328 1788 169 151 M16416 GO_LEUKOTRIENE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_METABOLIC_PROCESS.html The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 29/54 Gene Ontology BP GO:0006691 0.00234967757897774 0.00729131194801444 595 624 593 0.000213835534209012 289 1.65153525097473 -1.58699162394008 -1 12.057030900903 289 307 593 477 1476 594 704 707 327 591 799 152 M13725 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 36/61 Gene Ontology BP GO:0071380 0.000170825858886012 0.00111480045076664 205 1127.72727272727 594 1.55308295122283e-05 40 1.18525879779964 1.26417133081061 1 11.9550909308577 203 955 770 3720 2516 136 40 52 2853 566 594 153 M13459 GO_ERYTHROCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. 12/16 Gene Ontology BP GO:0043249 0.0020298445016127 0.00657720505989129 2060 1146.72727272727 596 0.000184701797617703 117 0.940576732931763 -1.15269016566596 -1 7.00604129206561 2057 506 2369 117 519 1787 2649 596 299 1368 347 154 M11043 GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of glia cell differentiation. 33/45 Gene Ontology BP GO:0045687 0.00262671484629019 0.00790051983179591 600 1495.54545454545 600 0.000239077844952422 165 1.13029859304709 1.28773730956297 1 8.11370274609786 600 3100 2055 2692 566 424 250 519 3920 2160 165 155 M16923 GO_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSSIFICATION.html Any process that modulates the frequency, rate or extent of bone formation. 196/250 Gene Ontology BP GO:0030278 1.20633523971486e-09 5.01167666999398e-08 380 868.909090909091 600 1.09666840034212e-10 31 1.44423023042717 1.47873399171621 1 36.0349752835714 376 1990 82 1884 2126 117 752 600 1513 87 31 156 M13341 GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of chondrocyte differentiation. 52/71 Gene Ontology BP GO:0032330 0.000460893705048752 0.00231092501033604 210 977.090909090909 603 4.19082081172858e-05 196 1.25042982464313 1.28472403613622 1 11.2595581246922 209 2139 749 2508 1645 265 603 196 1758 292 384 157 M13762 GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. 25/45 Gene Ontology BP GO:0031664 0.000333246925107734 0.00184156525240651 60 1174.45454545455 612 3.02997649713437e-05 10 1.15907700741704 1.15907700741704 1 10.8269174952253 58 2760 2058 2842 612 72 10 366 1475 2341 325 158 M13837 GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 111/138 Gene Ontology BP GO:0033209 0.00361813753486024 0.0100486525980105 410 1294.90909090909 612 0.000329463789944363 16 0.892041795452861 -0.864109279438152 -1 6.08259662551145 407 16 3284 550 642 233 612 836 3563 3642 459 159 M13599 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate, or extent of mast cell activation. 14/21 Gene Ontology BP GO:0033005 0.000351767486822427 0.00189880987956468 135 1308.90909090909 617 3.19839768215184e-05 14 1.07400517716498 1.07400517716498 1 9.98266396011606 135 1801 2422 2164 253 457 14 280 3462 2793 617 160 M14412 GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). 80/201 Gene Ontology BP GO:0007188 8.25879112462929e-05 0.000642611289346155 535 987.363636363636 617 7.50827379600915e-06 89 1.3081039219582 1.14488707725725 1 14.2652726783282 535 89 344 1747 2626 182 617 1763 1986 648 324 161 M12220 GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. 16/20 Gene Ontology BP GO:1902991 4.23293176161928e-05 0.00039391662973629 1495 1458.72727272727 619 3.84819382541406e-06 89 0.800536957353346 -0.76992601974032 -1 9.30769431824452 1493 431 2638 145 89 619 1898 310 4410 3500 513 162 M11359 GO_ARTERY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_DEVELOPMENT.html The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. 119/156 Gene Ontology BP GO:0060840 6.16299233292467e-07 1.15630658568946e-05 115 1049.90909090909 620 5.60272187218314e-08 111 1.3664707925261 1.4321449743692 1 23.054125727828 111 1449 189 2187 2295 421 766 620 2911 458 142 163 M12864 GO_BONE_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MINERALIZATION.html The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. 41/53 Gene Ontology BP GO:0030282 9.2390249595946e-06 0.000120417879935557 620 1055.90909090909 620 8.39914887239347e-07 26 1.60151653746242 1.72392400953971 1 21.4495168445742 620 1589 254 1758 3970 887 552 42 1432 485 26 164 M14156 GO_DRUG_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_METABOLIC_PROCESS.html The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. 28/89 Gene Ontology BP GO:0017144 0.000168510066100936 0.00110123221568491 410 1094.36363636364 622 1.53202704177594e-05 342 1.77633144225264 -1.81618032235667 -1 17.9545501594477 427 2228 380 1968 948 408 1191 622 3116 408 342 165 M13624 GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 20/24 Gene Ontology BP GO:0051043 0.000139232249910273 0.000968382150721226 160 856.636363636364 627 1.26582783942066e-05 141 1.21267035195749 -1.19525817903916 -1 12.4853564859121 1900 399 2169 476 158 627 141 864 158 1389 1142 166 M10985 GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. 21/23 Gene Ontology BP GO:2000050 0.000670489214099438 0.00300239717375867 715 895.545454545455 629 6.09721495335854e-05 35 1.62496305610751 1.64065562861093 1 14.0036746372026 712 2786 1591 1643 629 248 291 137 323 1456 35 167 M12009 GO_DECIDUALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DECIDUALIZATION.html The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. 20/25 Gene Ontology BP GO:0046697 0.0156488337801706 0.0292380457037111 365 852.636363636364 629 0.00143284244105471 97 1.72920994724483 1.74860997593693 1 9.05877005451742 364 396 1044 758 3643 629 410 1027 97 693 318 168 M14552 GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER.html The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. 86/91 Gene Ontology BP GO:0006890 0.00326686674670323 0.00933132656378768 380 1529.81818181818 629 0.000297429814090489 190 0.917900154064538 -0.947724189041655 -1 6.36016715036376 379 3003 4052 2114 610 190 438 822 359 4232 629 169 M13049 GO_CILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 212/278 Gene Ontology BP GO:0044782 0.000556672306282312 0.00262697387538702 460 978.454545454545 631 5.06193829626993e-05 7 1.09520486613262 -1.13824783258463 -1 9.65205051177845 459 681 1925 24 2915 7 581 1297 631 2148 95 170 M12879 GO_REGULATION_OF_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXCRETION.html Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. 15/33 Gene Ontology BP GO:0044062 0.00080459047092124 0.00340651452338174 345 1320.72727272727 634 7.31713526242087e-05 341 1.62996480651126 1.55649092470959 1 13.7411896637613 341 1160 482 2314 4119 634 421 515 3511 390 641 171 M11873 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE.html A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 18/19 Gene Ontology BP GO:0033539 0.00029637277453625 0.00169441789232652 1875 1302.63636363636 636 2.69466098087152e-05 90 0.673143900087827 -0.707766524905402 -1 6.36659016224599 1875 435 3631 192 225 558 1768 919 90 4000 636 172 M15225 GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of MAP kinase activity. 249/335 Gene Ontology BP GO:0043406 3.19511074003003e-05 0.000320406255891373 615 1130.18181818182 638 2.90468831300339e-06 97 1.22126207761326 1.22526356117979 1 14.579540923721 614 1380 297 638 3658 97 436 1609 2226 349 1128 173 M15111 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. 10/14 Gene Ontology BP GO:0033033 0.00357727719481763 0.00997905922511176 560 1789.27272727273 640 0.000325737022654939 270 1.19737095528091 1.19737095528091 1 8.18056079503562 557 3940 2672 3647 640 579 270 424 2954 3624 375 174 M14968 GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a humoral immune response. 38/65 Gene Ontology BP GO:0002920 6.38653363594398e-05 0.000537369638481869 940 1114.54545454545 642 5.80610822056742e-06 49 1.45752460278279 1.62034367489812 1 16.2830399773093 218 938 324 937 4100 461 642 444 3494 653 49 175 M15449 GO_KERATINIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINIZATION.html The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. 26/66 Gene Ontology BP GO:0031424 0.00201663050437704 0.0065537310993969 185 1209.81818181818 644 0.000183498311357509 183 2.17544654751959 -2.42512669374904 -1 16.229721261392 183 2738 573 1978 528 502 644 1912 2458 1179 613 176 M11094 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO.html The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. 11/18 Gene Ontology BP GO:0008595 6.78248458081466e-05 0.000562547250526393 695 1023.36363636364 646 6.16608517298315e-06 36 1.4245804716 1.13526874319032 1 15.817901248589 693 518 1260 185 114 1049 630 4326 36 1800 646 177 M14433 GO_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANOIKIS.html Any process that modulates the frequency, rate or extent of anoikis. 48/78 Gene Ontology BP GO:2000209 0.0102711164165512 0.0211000020689681 140 1047.09090909091 646 0.000938125895847817 136 1.16195012675387 1.23214725233558 1 6.64637027001773 136 195 2021 1910 1578 836 568 646 612 2463 553 178 M14898 GO_TRIPARTITE_REGIONAL_SUBDIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIPARTITE_REGIONAL_SUBDIVISION.html Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. 11/18 Gene Ontology BP GO:0007351 6.78248458081466e-05 0.000562547250526393 695 1024.72727272727 647 6.16608517298315e-06 37 1.4245804716 1.13526874319032 1 15.817901248589 694 519 1261 186 115 1050 631 4327 37 1805 647 179 M13906 GO_TRACHEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_DEVELOPMENT.html The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. 22/31 Gene Ontology BP GO:0060438 2.49917247712618e-05 0.000265494281645391 2370 1207.09090909091 651 2.27200078896763e-06 62 1.01831663316369 -0.840255976835547 -1 12.4392430266975 2369 372 2578 237 62 347 2442 651 664 2985 571 180 M15003 GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 68/87 Gene Ontology BP GO:0030148 0.00474661351914382 0.0121085486318948 2045 1001.27272727273 653 0.000432444147617389 54 1.33396457055583 -1.19657466439474 -1 8.73188397397607 2042 104 1229 54 1151 653 2031 2657 483 471 139 181 M10478 GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of cholesterol homeostasis. 14/18 Gene Ontology BP GO:2000188 0.000388575540163112 0.00202015864623348 400 1174.18181818182 658 3.53312899444691e-05 92 1.56042607945975 1.56042607945975 1 14.3651452431627 400 2858 2575 1595 658 732 267 92 401 2783 555 182 M10753 GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. 29/36 Gene Ontology BP GO:0045932 1.97423755841266e-05 0.000221887134282467 3445 1631.09090909091 660 1.79477752278384e-06 63 1.39420800586523 -1.42092857125158 -1 17.4063162817768 3443 282 276 299 63 1829 2610 4219 660 179 4082 183 M15261 GO_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. 267/410 Gene Ontology BP GO:0050727 2.96313795071112e-16 8.11028287332872e-14 350 1015.90909090909 661 2.69376177337373e-17 12 1.40949527320534 1.45673647913105 1 63.0745641271249 346 661 12 37 3993 688 1061 643 2579 29 1126 184 M15963 GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. 14/24 Gene Ontology BP GO:0036152 0.00115913859968136 0.0043920780979783 1155 767.181818181818 661 0.000105431798079123 52 1.27135072193284 -1.37099017239182 -1 10.2358990724572 572 1152 1414 52 661 645 1338 197 1048 1151 209 185 M13216 GO_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. 61/90 Gene Ontology BP GO:0048546 0.00201866916130206 0.00655468779311826 495 1020.18181818182 663 0.00018368398440303 346 1.37622568726833 1.48710343408231 1 10.2629910886768 663 1533 574 1435 3404 346 448 1005 830 492 492 186 M10979 GO_NOTCH_RECEPTOR_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_RECEPTOR_PROCESSING.html The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. 18/20 Gene Ontology BP GO:0007220 0.00318227971049964 0.00915151266560867 1650 1112.81818181818 671 0.000289717472012373 237 1.23197891528744 -1.31035639449779 -1 8.57567414089781 1647 425 2401 603 2084 671 1665 338 237 1594 576 187 M13309 GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 production. 54/103 Gene Ontology BP GO:0032652 0.000201305194010173 0.00126920469882024 465 694.545454545455 672 1.83021469336986e-05 225 1.43682069762103 1.55408541730397 1 14.2179898788098 461 875 392 846 402 672 969 225 1353 336 1109 188 M12916 GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. 184/216 Gene Ontology BP GO:0071559 0.00189521867097034 0.00630176943628747 610 1251.18181818182 673 0.000172441209416293 370 1.30601492440484 1.33997151496977 1 9.81516913618262 425 2529 562 2190 847 370 610 2168 2781 673 608 189 M13946 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. 12/13 Gene Ontology BP GO:0040015 9.04603943154852e-05 0.000691153061986786 675 1311.54545454545 675 8.22401037388856e-06 135 1.90215098686945 -2.1784747427893 -1 20.5427052221941 675 4227 1811 2337 135 302 1100 573 410 2582 275 190 M12413 GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 69/99 Gene Ontology BP GO:0070167 3.77333723809332e-06 5.50036604445877e-05 110 1002.45454545455 678 3.43031246360059e-07 59 1.53385459511334 1.63786529565578 1 22.3274400109563 108 2121 237 1262 3630 678 950 59 1638 264 80 191 M15149 GO_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 27/35 Gene Ontology BP GO:0046058 0.00102653759913695 0.00405170074115705 235 1182 680 9.33651729934193e-05 182 1.36581611002124 1.29155078384053 1 11.1608416253746 233 1670 657 2744 3069 361 369 182 2049 680 988 192 M16310 GO_ALKALOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). 12/31 Gene Ontology BP GO:0009820 1.80416544770993e-05 0.000205754456573389 4220 1798 683 1.64016385763024e-06 47 1.47375416158928 -1.60500902576997 -1 18.5652199010633 3261 475 683 269 47 4021 4216 4217 203 578 1808 193 M10192 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT.html The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/32 Gene Ontology BP GO:0043252 0.0038374030295926 0.010460126711596 1300 1228.81818181818 684 0.000384404572730345 73 1.79913101086094 -1.87450882091514 -1 12.1714314046613 1298 554 4231 474 684 1140 405 3173 73 1122 363 194 M13992 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 19/23 Gene Ontology BP GO:0009147 0.00182742884435166 0.00613493969175199 270 1222.54545454545 684 0.000166268051341099 92 0.816106280183837 -0.770125914240667 -1 6.16184301287284 266 2295 3446 1057 497 227 526 684 92 3238 1120 195 M15144 GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 149/237 Gene Ontology BP GO:0070374 6.14044971125088e-09 2.01207834552467e-07 685 1223.18181818182 684 5.5822270258087e-10 106 1.38792248516363 1.46628322206997 1 31.7651088594177 684 2536 106 1291 3014 154 635 1336 2844 318 537 196 M10678 GO_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 219/292 Gene Ontology BP GO:0002064 0.00457654578453568 0.0118106863757318 925 1141.27272727273 686 0.000416917632210794 359 1.20500045438673 1.16877731745545 1 7.93124205280134 921 683 677 359 2150 618 686 2995 1400 532 1533 197 M16809 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. 21/36 Gene Ontology BP GO:0010575 0.00422693669032544 0.0111813168960115 205 721 689 0.00038500726944635 131 1.33442545805016 1.37925357647143 1 8.89275722420634 205 362 700 1242 689 537 131 1006 1616 781 662 198 M10890 GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. 60/70 Gene Ontology BP GO:0045600 0.00294458822810844 0.00861764758525369 215 1010.81818181818 691 0.000268048800982066 212 1.28130618213385 1.38830688543995 1 9.03381787632396 212 862 687 3039 1954 403 691 325 1502 1110 334 199 M11332 GO_GANGLIOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 20/27 Gene Ontology BP GO:0001573 2.34385023853232e-05 0.000252452202775252 1615 1246.27272727273 692 2.13079564542559e-06 9 1.9072790795279 2.08770147249051 1 23.4503197094908 1613 1718 639 720 4559 2099 681 9 405 692 574 200 M10068 GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0052192 0.00439257930091264 0.0114702123219346 260 813.454545454545 693 0.00040012493066149 258 1.28188088937735 1.37043121328631 1 8.49362105222803 258 2068 841 1208 693 284 457 580 1306 739 514 201 M10251 GO_REGULATION_OF_VESICLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_FUSION.html Any process that modulates the frequency, rate or extent of vesicle fusion. 56/71 Gene Ontology BP GO:0031338 0.00577426225782821 0.0134540021460564 1120 1220.72727272727 693 0.000526315789473684 88 0.913089063301883 -0.935729550182841 -1 5.83069515124649 1119 132 3233 88 2675 439 1253 693 164 3176 456 202 M10524 GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0051806 0.00283135458058128 0.0083593228828964 260 790.454545454545 694 0.000257727732226047 259 1.28188088937735 1.37043121328631 1 9.0958033022538 259 2069 842 1209 694 285 458 317 1307 740 515 203 M14280 GO_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_CHEMOTAXIS.html The directed movement of a lymphocyte in response to an external stimulus. 20/56 Gene Ontology BP GO:0048247 0.000617941052046706 0.00283838076522539 605 1141.63636363636 694 5.61922444574954e-05 357 1.74586300710401 1.68067627380731 1 15.1919935589531 602 1714 462 514 3716 357 532 1039 1264 694 1664 204 M14252 GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. 195/250 Gene Ontology BP GO:0006575 0.00181469008045053 0.00610097756093664 800 921.909090909091 695 0.000165108061363077 13 1.31958321144234 -1.30498041384455 -1 9.98069723780798 797 695 557 13 2459 387 1521 1346 565 420 1381 205 M15136 GO_MOVEMENT_IN_HOST_ENVIRONMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_HOST_ENVIRONMENT.html The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0052126 0.00439257930091264 0.0114702123219346 265 807.272727272727 697 0.00040012493066149 262 1.28188088937735 1.37043121328631 1 8.49362105222803 262 2072 845 1212 697 288 461 472 1310 743 518 206 M10703 GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS.html The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 182/306 Gene Ontology BP GO:0050954 1.2525120169832e-06 2.05934219612114e-05 350 942.545454545455 698 1.13864793642589e-07 120 1.25164952095872 1.26547932478387 1 20.0434105913059 347 1401 214 734 1820 616 698 2019 1965 434 120 207 M10733 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. 40/59 Gene Ontology BP GO:0050974 0.000132248866050211 0.00093628649296474 30 1244.72727272727 698 1.20233469646731e-05 30 1.46401112892176 1.370682432819 1 15.1485782537076 30 2675 365 2463 991 553 593 1570 3179 575 698 208 M13804 GO_EPIBOLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIBOLY.html The expansion of one cell sheet over other cells or yolk. 47/53 Gene Ontology BP GO:0090504 2.13048456420862e-05 0.000236027254220541 75 989.454545454545 698 1.93682290558642e-06 74 1.4504762182417 1.36692309129325 1 17.9761874196623 74 894 278 1307 1190 698 688 2549 2288 270 648 209 M15286 GO_ENTRY_INTO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST.html Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0044409 0.00439257930091264 0.0114702123219346 265 804.545454545455 698 0.00040012493066149 263 1.28188088937735 1.37043121328631 1 8.49362105222803 263 2073 846 1213 698 289 462 432 1311 744 519 210 M16749 GO_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST_CELL.html The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0030260 0.00439257930091264 0.0114702123219346 265 819.272727272727 699 0.00040012493066149 264 1.28188088937735 1.37043121328631 1 8.49362105222803 264 2074 847 1214 699 290 463 584 1312 745 520 211 M10826 GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 189/257 Gene Ontology BP GO:0046395 0.0013250690342673 0.00488166762980662 570 954.545454545455 700 0.000120533436582825 31 1.13283761418299 -1.10982113776886 -1 8.94177192733085 570 700 1732 31 436 303 1797 505 1776 1751 899 212 M12273 GO_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_PAIN.html The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. 71/149 Gene Ontology BP GO:0019233 0.000641729668666783 0.00292169094746237 395 1042.36363636364 700 5.83560849705869e-05 317 1.44429643287646 1.47275456185039 1 12.5039680704647 395 2114 464 1853 1556 700 1245 422 1954 446 317 213 M13128 GO_ORGANIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. 189/257 Gene Ontology BP GO:0016054 0.0013250690342673 0.00488166762980662 575 944.545454545455 701 0.000120533436582825 32 1.13283761418299 -1.10982113776886 -1 8.94177192733085 571 701 1733 32 437 304 1798 385 1777 1752 900 214 M15790 GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT.html The progression of the atrioventricular valve over time, from its formation to the mature structure. 23/30 Gene Ontology BP GO:0003171 0.00217398813509491 0.00690482374921271 300 1341.18181818182 710 0.000197830854151107 283 1.44078420678677 1.60370222284038 1 10.6335967833232 296 3481 1611 3511 710 368 496 283 1539 2157 301 215 M16891 GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. 27/55 Gene Ontology BP GO:0090022 0.00256690018246609 0.00778604077510738 805 1054.81818181818 710 0.000233627279383447 157 1.66240217045029 1.70541778295056 1 11.9743880346205 801 1663 606 554 4034 788 710 942 666 682 157 216 M16147 GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS.html The process in which the structure of the atrioventricular valve is generated and organized. 23/26 Gene Ontology BP GO:0003181 0.00197925017185387 0.0064722881455389 300 1340.81818181818 711 0.000180093915311108 269 1.44078420678677 1.60370222284038 1 10.7719905671617 297 3482 1612 3512 711 369 497 269 1540 2158 302 217 M10764 GO_RESPONSE_TO_CORTICOSTEROID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTEROID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 196/288 Gene Ontology BP GO:0031960 4.19820146977653e-13 5.008777292018e-11 330 777.909090909091 713 3.81654679070666e-14 27 1.41882710049058 1.38221583779185 1 49.9548592086283 328 1394 27 746 713 161 741 2198 1859 42 348 218 M16638 GO_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. 64/88 Gene Ontology BP GO:0055072 0.0129035648274124 0.025163573823114 625 1098.90909090909 713 0.00117998862704407 243 1.15784108262869 1.17789894886901 1 6.32003633393818 621 846 1704 1188 4465 243 591 759 394 564 713 219 M11444 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. 198/266 Gene Ontology BP GO:0048002 0.0131871513336297 0.0256024906121379 315 1261.72727272727 715 0.00120607881745536 224 0.979863954212149 -0.886344059034505 -1 5.3217562660072 314 691 3108 715 1378 224 557 1335 1040 3956 561 220 M12033 GO_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_MEDIATED_IMMUNITY.html Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. 57/269 Gene Ontology BP GO:0019724 0.000979484548797571 0.0039156949437776 280 1294.27272727273 715 8.90837188329787e-05 175 1.24924084899367 1.27677790149893 1 10.2706642518623 279 2132 566 1227 4521 503 349 175 2823 947 715 221 M10852 GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT.html The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. 15/16 Gene Ontology BP GO:0099514 0.000155214386852865 0.00104132677153963 720 1606.09090909091 716 1.41113944199191e-05 84 1.24854202274608 -1.24854202274608 -1 12.7203619382011 716 2855 3575 3947 167 443 84 352 1773 3434 321 222 M13210 GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. 17/17 Gene Ontology BP GO:2000303 8.59853350711397e-05 0.000663498779578795 1205 971.909090909091 716 7.81715417516264e-06 130 0.970254219447499 1.25888496553223 1 10.5320821311568 1203 445 2335 446 130 716 1592 1095 451 2038 240 223 M11261 GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT.html The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. 15/16 Gene Ontology BP GO:0048490 0.000155214386852865 0.00104132677153963 720 1616 717 1.41113944199191e-05 85 1.24854202274608 -1.24854202274608 -1 12.7203619382011 717 2856 3576 3948 168 444 85 449 1774 3437 322 224 M10831 GO_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. 14/28 Gene Ontology BP GO:0046068 0.0036276784332446 0.0100653474954604 1990 1238.18181818182 718 0.000330334010934257 496 1.49691963908189 1.36736545237451 1 10.2106388754532 1987 496 679 712 644 3235 1230 718 697 768 2454 225 M11922 GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. 15/16 Gene Ontology BP GO:0099517 0.000155214386852865 0.00104132677153963 720 1605.18181818182 718 1.41113944199191e-05 86 1.24854202274608 -1.24854202274608 -1 12.7203619382011 718 2857 3577 3949 169 445 86 319 1775 3439 323 226 M12783 GO_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIOGENESIS.html The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. 187/263 Gene Ontology BP GO:0042063 3.56017433948905e-05 0.00034226221490997 720 1317.90909090909 720 3.23657450337224e-06 293 1.22555997337024 1.37429648051475 1 14.5108066537899 638 1397 302 1322 4060 719 720 1678 2707 293 661 227 M10248 GO_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION.html The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 411/1652 Gene Ontology BP GO:0007600 5.45866518691509e-12 4.031614145193e-10 420 1152.63636363636 721 4.96242289720786e-13 43 1.27833002562556 1.30825661113458 1 41.0484963096709 419 1349 43 2967 2465 412 1094 721 2932 195 82 228 M10805 GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION.html Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 24/28 Gene Ontology BP GO:0010544 4.3425281488671e-05 0.000400908402315052 320 1179.18181818182 721 3.94783078852321e-06 307 1.71790262265701 1.40789836151951 1 19.9410752612378 316 3145 307 2597 737 798 388 426 2847 721 689 229 M12487 GO_LIPOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOXYGENASE_PATHWAY.html The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. 10/15 Gene Ontology BP GO:0019372 0.00483773005268245 0.0122938055352984 660 772.272727272727 721 0.000440763721148818 60 1.90444003039481 1.63144749846272 1 12.4277338521692 658 1853 977 736 1241 721 522 425 60 1080 222 230 M16663 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY.html Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. 12/14 Gene Ontology BP GO:2000095 0.000113098151135185 0.000826131392828908 755 983.636363636364 721 1.02821787028874e-05 36 1.61299114477946 1.77857150990935 1 16.9909846436557 753 2377 1656 1616 721 313 138 36 549 2589 72 231 M10356 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. 167/205 Gene Ontology BP GO:1903321 0.00652347458119102 0.0147658264551095 295 1488.54545454545 723 0.000594808979476095 173 0.820332483991877 -0.814554692820593 -1 5.12397168900524 293 723 4044 667 2422 173 908 517 2300 3899 428 232 M10471 GO_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 42/70 Gene Ontology BP GO:0051602 0.00658132093732203 0.0148667942960844 920 774.545454545455 723 0.000600099261288917 194 1.18361621903046 1.16070408140532 1 7.38586481418197 919 194 975 752 2073 723 211 524 922 517 710 233 M15573 GO_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. 33/132 Gene Ontology BP GO:0009620 1.86926580321737e-06 2.97866225423644e-05 550 877 724 1.6993339922467e-07 221 1.78299675391828 1.73804587770433 1 27.5795772960198 550 1630 221 800 1394 1698 724 465 1241 358 566 234 M13445 GO_LIVER_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIVER_REGENERATION.html The regrowth of lost or destroyed liver. 20/26 Gene Ontology BP GO:0097421 0.000163138240260032 0.00107215004509877 55 988.090909090909 725 1.48318489843298e-05 28 1.03830387332886 1.09198396955418 1 10.5316517568577 52 1088 2750 1374 181 329 28 623 725 2827 892 235 M14617 GO_IRON_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_IMPORT.html The directed movement of iron ions into a cell or organelle. 12/16 Gene Ontology BP GO:0097286 0.000427108785720622 0.00217873601332866 730 637.363636363636 728 3.88356115742666e-05 227 1.51049938725317 1.52295301034112 1 13.7356948960358 728 510 1419 785 275 752 394 259 227 892 770 236 M16172 GO_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_IMPORT.html The directed movement of amino acids into a cell or organelle. 13/29 Gene Ontology BP GO:0043090 0.00145048768358874 0.00519163014749108 295 787.727272727273 728 0.000131949535638787 51 1.39014973523805 1.19942834547539 1 10.8481531067042 291 1185 1172 1740 1483 374 51 260 728 1025 356 237 M11101 GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 11/21 Gene Ontology BP GO:0042136 0.000610583140020525 0.00281291420843119 840 1069 730 5.55229696172514e-05 94 1.62370134716996 -1.62370134716996 -1 14.1499610456444 840 1225 957 572 730 331 94 131 4247 2470 162 238 M10935 GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 24/26 Gene Ontology BP GO:0071498 0.00195151021201262 0.00641104466609068 735 1088.36363636364 731 0.000177567586561428 290 1.46216226227549 1.78854456276234 1 10.9526226346007 731 1704 1914 2676 511 689 290 376 1296 1352 433 239 M15544 GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH.html Any process that modulates the extent of cell growth. 126/153 Gene Ontology BP GO:0061387 0.000116172938544207 0.000843295917388756 415 1150.54545454545 732 1.05617339647411e-05 207 1.37685154376353 1.34071653332597 1 14.4599267015137 413 2042 359 1279 3300 343 732 2197 1478 306 207 240 M10802 GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM.html The growth process in which a branch increases in length from its base to its tip. 19/23 Gene Ontology BP GO:0060602 0.000613861761953761 0.0028224296228961 410 1721.81818181818 734 5.5821192141734e-05 308 1.51991111090059 -1.58514693185686 -1 13.2371643006164 3179 410 734 656 1832 4113 4522 2251 408 308 527 241 M10380 GO_ANTIMICROBIAL_HUMORAL_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIMICROBIAL_HUMORAL_RESPONSE.html An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. 43/176 Gene Ontology BP GO:0019730 0.00342386037153322 0.00967287329006926 150 1430.27272727273 736 0.000311745505905211 145 1.70873249490631 -1.63664532808177 -1 11.7578559773082 147 4395 688 4319 621 145 826 713 2245 898 736 242 M13571 GO_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_HOST.html An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 149/213 Gene Ontology BP GO:0051701 0.0231737948418204 0.0399657773902855 330 876.636363636364 737 0.00212923259667975 311 1.26047449933638 1.38130355626415 1 6.01535607607117 327 1428 1408 311 1932 431 737 921 928 641 579 243 M13607 GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. 20/22 Gene Ontology BP GO:0034315 0.000511889689544896 0.00245802138849577 600 1580.90909090909 738 4.65462575802029e-05 221 0.888072624102022 -0.913205532358108 -1 7.91223307096857 599 3516 3640 3168 301 241 246 1023 221 3697 738 244 M13572 GO_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION.html A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. 174/242 Gene Ontology BP GO:0007369 4.85030334603705e-05 0.000440790263068563 180 1358.90909090909 739 4.40946389378865e-06 178 1.26519937789101 1.29044978448642 1 14.5052154797405 178 3298 311 2453 2773 283 739 538 3361 776 238 245 M12914 GO_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_ENTRY_INTO_HOST_CELL.html The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. 92/135 Gene Ontology BP GO:0046718 0.00439257930091264 0.0114702123219346 745 830.181818181818 741 0.00040012493066149 260 1.28188088937735 1.37043121328631 1 8.49362105222803 260 2070 843 1210 695 286 459 744 1308 741 516 246 M12938 GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0051828 0.00439257930091264 0.0114702123219346 745 831.181818181818 742 0.00040012493066149 261 1.28188088937735 1.37043121328631 1 8.49362105222803 261 2071 844 1211 696 287 460 745 1309 742 517 247 M11210 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 17/21 Gene Ontology BP GO:0009148 0.000744692365237591 0.00322176520094511 435 1304.27272727273 743 6.77222327764642e-05 96 0.8378097756748 -0.788361285381314 -1 7.12722175886468 431 2317 3377 2042 352 325 743 475 96 3070 1119 248 M12684 GO_PONS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PONS_DEVELOPMENT.html The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. 10/20 Gene Ontology BP GO:0021548 0.000366044419378213 0.00195321638000782 745 1440.72727272727 744 3.32823034036474e-05 86 1.20920493751508 1.35082911901952 1 11.1899389561646 744 2397 2695 1660 3109 676 109 86 315 3619 438 249 M10525 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 143/187 Gene Ontology BP GO:0014066 0.00419264194024477 0.0111158763236233 490 1497.81818181818 745 0.00038187758504149 171 1.11630530645885 1.19268278863812 1 7.4471672234811 488 745 659 3391 3697 171 435 951 3534 1869 536 250 M15828 GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. 161/235 Gene Ontology BP GO:0060041 0.000159607680460171 0.0010544400883759 400 1196 746 1.45108419095768e-05 296 1.27509543123863 1.24395487426634 1 12.9674261721335 396 2532 376 1856 1286 296 746 1779 2604 703 582 251 M12794 GO_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. 232/316 Gene Ontology BP GO:0019882 0.00924421685624018 0.0194542474138786 700 1451.72727272727 747 0.000843935485177166 158 0.986904924605789 -0.910196783542414 -1 5.76250370659303 699 672 3163 718 2180 158 747 1974 1347 3869 442 252 M15173 GO_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. 139/169 Gene Ontology BP GO:0001952 0.000246083325700789 0.0014736329318494 225 1331.81818181818 747 2.23737141747833e-05 10 1.21340236328366 1.31076897375149 1 11.7364407665682 222 2031 501 2449 3647 181 982 337 3543 747 10 253 M13452 GO_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that modulates the amount of sodium excreted in urine over a unit of time. 13/27 Gene Ontology BP GO:0035813 0.000768450853818039 0.00330462275676094 745 1231.45454545455 748 6.98835819854112e-05 451 1.63625168646327 1.55407778724765 1 13.8680105196532 741 1182 478 2310 1585 954 717 748 3643 451 737 254 M13690 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER.html The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. 21/39 Gene Ontology BP GO:0048791 0.00167920718298592 0.00580055755191795 3155 1317.09090909091 748 0.000152771841163196 39 1.49883721923414 -1.75158459624393 -1 11.4503148805656 3151 342 748 39 480 2676 3998 1923 104 779 248 255 M16661 GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS.html Any process that alters the size or shape of an auditory receptor cell. 16/25 Gene Ontology BP GO:0002093 0.0139975269902491 0.0267476357641187 750 1612.63636363636 750 0.00128067162646479 259 1.48247554535306 1.5854644403163 1 7.96065046369207 609 4193 2854 4178 1011 259 356 750 322 2459 748 256 M15447 GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 99/136 Gene Ontology BP GO:0072329 0.001713639877286 0.00587155106701895 635 1102 751 0.000155906921403696 42 0.980555563235574 -0.984729061792195 -1 7.46952168038469 635 42 2762 49 488 272 1716 751 1664 2722 1021 257 M15238 GO_COENZYME_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 16/22 Gene Ontology BP GO:0009109 0.00216086469528765 0.00686783020981791 755 1227.36363636364 752 0.000196635458543636 169 1.34498298084411 -1.23507230591419 -1 9.93656257527553 752 2828 2667 2022 1603 218 169 282 210 2454 296 258 M14053 GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell. 36/77 Gene Ontology BP GO:0050710 5.38936848142614e-05 0.000478563579085417 230 851.090909090909 754 4.89954591819238e-06 17 1.40997242857598 1.50099704084847 1 15.9940917385545 226 1616 729 1752 1890 244 420 17 895 754 819 259 M12192 GO_DETECTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS.html The series of events by which a mechanical stimulus is received and converted into a molecular signal. 55/82 Gene Ontology BP GO:0050982 0.000174998285500878 0.0011388349964134 15 747.727272727273 758 1.59102006575498e-05 11 1.36806062583585 1.31855876042914 1 13.7572334833255 11 873 415 1398 758 85 212 808 2667 846 152 260 M14994 GO_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_ACTIVATION.html Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 37/56 Gene Ontology BP GO:0010543 1.15448003433349e-05 0.000143630898389138 135 1705.81818181818 760 1.04953281151781e-06 134 1.47874788017764 1.25079528490832 1 19.417374319251 134 3409 262 3330 4483 760 185 598 4073 809 721 261 M10530 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 97/150 Gene Ontology BP GO:0071347 0.000685060016969832 0.00304945600406369 50 1065.90909090909 761 6.22975846799868e-05 48 1.24325916260182 1.35983483921065 1 10.6829963886222 48 2997 948 2205 1106 81 276 139 2680 761 484 262 M15890 GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). 44/109 Gene Ontology BP GO:0007189 0.00236932543693759 0.00732523007180771 765 898.545454545455 762 0.000215625543098173 205 1.35320937386391 1.08088409118266 1 9.86785193080818 762 205 596 1039 912 491 367 1906 1941 953 712 263 M16194 GO_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TISSUE_REMODELING.html Any process that modulates the frequency, rate, or extent of tissue remodeling. 63/85 Gene Ontology BP GO:0034103 1.6718313930913e-10 8.83980849097022e-09 670 1223.36363636364 762 1.51984672110758e-11 63 1.79149814048972 2.03062580692039 1 49.3176798035077 669 131 63 762 4259 2484 1883 176 1653 124 1253 264 M10369 GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoclast differentiation. 79/137 Gene Ontology BP GO:0045670 0.000870688923725367 0.00360116938852812 40 1570.45454545455 763 7.91848823019633e-05 37 1.49874343679806 1.45565824807537 1 12.5104258325589 37 4009 780 3762 3116 475 412 161 3264 763 496 265 M11549 GO_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_PROLIFERATION.html The expansion of a muscle cell population by cell division. 28/33 Gene Ontology BP GO:0033002 0.000349332263300449 0.0018922503156426 310 597.272727272727 763 3.17625222903427e-05 44 1.40194912760774 1.45990085305243 1 13.0412970856917 309 1006 937 763 1225 126 307 81 771 1001 44 266 M12631 GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of adherens junction organization. 94/107 Gene Ontology BP GO:1903391 0.00322135072201246 0.00923816811064314 165 1009 763 0.000293279752537466 106 1.24726611811621 1.29680780706094 1 8.66476521386512 163 800 626 911 2841 494 763 350 3237 808 106 267 M16855 GO_STEROID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 20/65 Gene Ontology BP GO:0006706 0.00576959803779957 0.0134540021460564 1980 1545.36363636364 763 0.00052588953222205 470 1.47820144967174 1.26390856493691 1 9.44592156049747 1980 2789 763 2494 4002 470 622 480 2183 695 521 268 M13153 GO_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 31/40 Gene Ontology BP GO:0010939 5.71569969048315e-05 0.000495432304635197 415 986.909090909091 764 5.1962256294114e-06 8 1.33991075307043 -1.43660485083939 -1 15.1298928994318 412 1649 2443 1067 1349 582 764 21 566 1995 8 269 M15521 GO_REGULATION_OF_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. 23/43 Gene Ontology BP GO:0098801 0.00380196690364331 0.0103878755153566 155 1720.81818181818 766 0.000346232116121398 155 1.34344067299104 1.24670406286989 1 9.09973337575314 155 3490 647 3740 3411 448 343 735 4281 913 766 270 M15796 GO_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. 27/31 Gene Ontology BP GO:0032528 0.000433423536003598 0.00220406526013633 775 1266.36363636364 771 3.94099044214588e-05 64 0.787738409951423 0.795009810767811 1 7.14466128191894 771 315 3412 1340 277 1048 64 633 581 3661 1828 271 M15100 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 34/49 Gene Ontology BP GO:0032228 0.000346891720655884 0.00188657907400686 3310 1612.18181818182 772 3.15405845404596e-05 74 1.52263053014645 -1.58333009282708 -1 14.1716110187038 3307 263 772 74 248 3888 4543 1566 214 375 2484 272 M15223 GO_SENSORY_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. 498/760 Gene Ontology BP GO:0007423 1.681411084806e-12 1.50453957261583e-10 430 1067.81818181818 772 1.52855553164299e-13 15 1.24136503301515 1.26471489678822 1 41.6780249171865 430 2457 35 1728 2629 15 772 794 2670 78 138 273 M11484 GO_MEMBRANE_RAFT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_RAFT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. 21/25 Gene Ontology BP GO:0031579 0.000137490382705405 0.000960574700793171 775 869.090909090909 773 1.24999069095596e-05 155 1.19183614911076 -1.24621537031032 -1 12.2849950376839 773 359 1484 293 155 884 2551 1031 428 1090 512 274 M12926 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 50/63 Gene Ontology BP GO:2001240 0.000745830835458635 0.00322176520094511 35 1518.81818181818 773 6.78258002397127e-05 13 1.16265921882332 1.17850928390213 1 9.89484022183373 32 3371 731 3454 773 13 82 1755 4206 2267 23 275 M11141 GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. 30/52 Gene Ontology BP GO:0050869 0.00104306837130465 0.00409915298283829 590 1353.18181818182 774 9.48693855877184e-05 186 1.32598658363609 1.34328390537108 1 10.8121367728546 588 285 1392 1247 4466 1891 774 186 705 637 2714 276 M16493 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. 50/63 Gene Ontology BP GO:1901099 0.000745830835458635 0.00322176520094511 35 1515.90909090909 774 6.78258002397127e-05 14 1.16265921882332 1.17850928390213 1 9.89484022183373 33 3372 732 3455 774 14 83 1711 4207 2270 24 277 M12492 GO_ARTERY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_MORPHOGENESIS.html The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. 76/97 Gene Ontology BP GO:0048844 1.39802925241165e-07 3.12741832282278e-06 85 1018.18181818182 776 1.27093576477447e-08 82 1.45768444479449 1.54264777610445 1 27.4239344203096 82 1512 157 1145 2433 776 1007 722 2775 374 217 278 M13602 GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS.html The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. 93/145 Gene Ontology BP GO:0044236 1.00196105678374e-15 2.59006933178597e-13 45 889.636363636364 776 9.1087368798522e-17 13 1.55169143911209 1.47152445212051 1 66.7636257423695 45 1468 13 1182 656 740 776 1197 2674 105 930 279 M13047 GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. 21/22 Gene Ontology BP GO:1903055 0.0017127560150247 0.00587155106701895 235 1523.36363636364 778 0.000155826444940985 232 1.62403889731404 1.7016597891679 1 12.3783449930453 232 3818 1863 3318 4107 294 599 235 640 778 873 280 M16273 GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 78/95 Gene Ontology BP GO:0014068 0.000783200933453109 0.00334333389298837 105 1490.54545454545 778 7.12254447600834e-05 101 1.29325480505237 1.34494946463101 1 10.9363501210806 101 2101 479 3826 2326 497 389 778 3663 1520 716 281 M11054 GO_BARBED_END_ACTIN_FILAMENT_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BARBED_END_ACTIN_FILAMENT_CAPPING.html The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. 14/19 Gene Ontology BP GO:0051016 0.00507346282802348 0.0127466644377933 1195 958.181818181818 779 0.000462290977602338 198 1.18108616365542 -1.23242975742423 -1 7.6398813448485 1193 1795 2490 594 1049 779 198 440 393 1139 470 282 M13801 GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 562/821 Gene Ontology BP GO:0000904 4.60790735049456e-06 6.54203144227907e-05 275 1571.54545454545 783 4.60791690528701e-07 135 1.28842948823188 1.32385940734052 1 18.4214270235003 272 2452 4450 2262 4098 205 563 783 1795 135 272 283 M14104 GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. 14/18 Gene Ontology BP GO:0042754 0.00469865832068124 0.0120191628181033 695 1111.45454545455 785 0.000428065782419039 145 1.33895633020242 1.40054085517199 1 8.77932984736218 691 2334 2591 1845 785 211 145 683 148 1635 1158 284 M16729 GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 20/23 Gene Ontology BP GO:0048569 2.19961193685468e-06 3.43449474569961e-05 700 1487.09090909091 785 1.99964921461973e-07 9 1.13187588735664 1.2959108287471 1 17.2647627719499 697 2803 1751 3509 9 216 279 711 3235 2363 785 285 M15314 GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. 10/16 Gene Ontology BP GO:0072505 0.00694266424446499 0.015515954240872 400 956.818181818182 786 0.000633151899123479 284 1.8303500570071 2.24076023753569 1 11.3112112397181 399 1227 823 786 2666 1660 543 536 931 670 284 286 M10910 GO_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROTIC_CELL_DEATH.html A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. 41/55 Gene Ontology BP GO:0070265 0.00644045750868264 0.014632543353467 790 1066.81818181818 787 0.000587217223757053 174 1.14913869005159 1.06723998418351 1 7.19751079418347 787 207 1765 337 3402 451 174 1408 638 1034 1532 287 M16301 GO_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that modulates the frequency, rate or extent of neutrophil migration. 31/60 Gene Ontology BP GO:1902622 0.000304057198115227 0.00172323768919629 1230 983.727272727273 787 2.76453844845277e-05 396 1.69874615589768 1.75765258716299 1 16.0404336226687 1227 974 419 492 3297 787 798 1260 576 396 595 288 M12034 GO_AORTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_DEVELOPMENT.html The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. 81/106 Gene Ontology BP GO:0035904 8.68399046311558e-06 0.000114466310552059 45 1093.81818181818 788 7.89456794667826e-07 42 1.37685963012931 1.42300188665018 1 18.5427598124749 42 1504 253 3113 788 270 513 1113 3261 996 179 289 M12429 GO_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 102/151 Gene Ontology BP GO:0009308 0.000443997972801625 0.00224556800809344 790 1026.36363636364 789 4.03716004165511e-05 28 1.45573634286263 -1.5323603183995 -1 13.1720143767042 2419 789 440 28 1308 648 1834 1994 711 329 790 290 M14200 GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS.html A multicellular organism process which involves another multicellular organism of the same or different species. 213/337 Gene Ontology BP GO:0044706 1.13295678380152e-10 6.3513830301548e-09 765 972.909090909091 792 1.02996071259988e-11 58 1.4029228444101 1.48164776171355 1 39.307038342512 761 1385 58 500 1312 1290 1645 792 1881 411 667 291 M16940 GO_REGULATION_OF_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of T cell migration. 18/35 Gene Ontology BP GO:2000404 0.0062088204708203 0.0142103500495459 2125 1548.90909090909 793 0.000566037499588877 456 2.00067326933633 -1.73705177791163 -1 12.625883856355 2122 2800 719 520 3173 456 547 2909 793 557 2442 292 M15210 GO_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS.html Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. 92/117 Gene Ontology BP GO:0050764 8.48443030945126e-05 0.000656872782527067 690 925.545454545455 794 7.71341594018109e-06 346 1.32353367263983 1.30750990278496 1 14.3905272697983 688 794 346 489 1210 426 1558 1410 1381 443 1436 293 M13521 GO_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_REMODELING.html Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. 45/59 Gene Ontology BP GO:0046850 1.96608498097419e-09 7.75270628514653e-08 335 683.181818181818 795 1.78734998430112e-10 88 1.98261736151923 2.05949289127562 1 48.1879249816442 334 900 88 312 1058 1585 1085 121 1125 112 795 294 M12958 GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA.html Any process of the innate immune response that takes place in the mucosal tissues. 11/97 Gene Ontology BP GO:0002227 0.000340700531040911 0.00186284320908738 875 1255.27272727273 796 3.09775731534979e-05 11 2.25353704300986 -2.07509722909552 -1 21.0218769784336 874 2898 668 3686 722 113 11 257 2826 796 957 295 M11131 GO_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. 110/119 Gene Ontology BP GO:0032543 0.000890561931587843 0.00365091160147862 20 1606.90909090909 797 8.09929669341109e-05 19 0.620013768507045 -0.613409131417825 -1 5.15654542199012 19 771 4173 1528 647 797 782 1813 615 4411 2120 296 M12919 GO_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_PHOSPHORYLATION.html The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 83/99 Gene Ontology BP GO:0006119 1.15341604143062e-07 2.71052769736195e-06 5 1267.45454545455 797 1.04856009263811e-08 1 0.586007242960351 -0.588218915093021 -1 11.1428693535318 1 797 4072 947 498 195 136 896 776 4392 1232 297 M16954 GO_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of vasculature development. 269/372 Gene Ontology BP GO:1901342 5.86987889754334e-15 1.30059745286996e-12 180 1199.36363636364 797 5.33625354322121e-16 16 1.41776117130705 1.42180282577497 1 57.6030681251271 180 2495 16 2818 1487 699 962 797 2985 117 637 298 M11168 GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. 36/51 Gene Ontology BP GO:0034122 1.53543998449086e-05 0.000181791405797353 5 819.454545454545 798 1.39586427349988e-06 5 1.12788626879064 1.05176628503079 1 14.4131099423182 5 944 1654 1834 1531 49 19 156 798 1588 436 299 M15217 GO_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. 395/509 Gene Ontology BP GO:0035239 1.83263529671227e-08 5.46618720230911e-07 800 1149.81818181818 799 1.66603210179856e-09 116 1.22233291830003 1.20924468553018 1 26.1601294281656 799 1926 116 793 2177 392 1580 1541 2280 256 788 300 M12677 GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. 49/63 Gene Ontology BP GO:0009201 0.00267451167155006 0.00800804556481496 65 1420.81818181818 804 0.000243433507767625 65 0.695745785155768 -0.676942229541588 -1 4.97625691227029 65 1573 3933 2132 569 307 207 804 792 4043 1204 301 M14587 GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 15/26 Gene Ontology BP GO:0032924 0.000287188417540237 0.00165977342255182 615 1744.36363636364 804 2.6111446729424e-05 72 1.10129933861374 1.21815564374602 1 10.456644375931 615 3211 2968 2879 4509 747 278 72 730 2375 804 302 M15266 GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 28/33 Gene Ontology BP GO:0060317 0.00284516918964424 0.00838414961330884 480 1186.09090909091 804 0.000258986855033426 478 1.47932447296446 1.59891430828056 1 10.4919261356693 478 2723 617 2118 797 804 534 501 2228 1006 1241 303 M11743 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that modulates the frequency, rate or extent of extracellular matrix organization. 41/44 Gene Ontology BP GO:1903053 0.00103016025004681 0.00406105195910816 75 1350.54545454545 805 9.3694813076931e-05 12 1.3934803990959 1.45636094752896 1 11.3823479766828 75 3393 1215 2226 3847 12 259 226 2432 805 366 304 M12990 GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 231/352 Gene Ontology BP GO:0070372 8.64138373082697e-08 2.15017959890577e-06 740 1169.72727272727 805 7.8558037002291e-09 141 1.31003611728487 1.38241871725556 1 25.3738686665375 740 1961 141 837 3352 201 580 1341 2692 217 805 305 M14227 GO_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of B cell activation. 102/269 Gene Ontology BP GO:0050864 0.00263411689826696 0.00791766532793035 665 1299.27272727273 805 0.00023975237194928 46 1.18964825731816 1.1960945896167 1 8.5364672435199 662 46 829 565 4068 1103 805 308 3177 538 2191 306 M15098 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. 15/16 Gene Ontology BP GO:0003198 0.00169581990366211 0.00583627959448211 520 1058.90909090909 807 0.000154284409110885 101 1.74086651861262 1.64593223112126 1 13.2851411796385 518 2836 867 2157 483 101 132 559 1421 1767 807 307 M11152 GO_RESPONSE_TO_MORPHINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MORPHINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. 28/40 Gene Ontology BP GO:0043278 0.000957915964003045 0.00384571439215373 405 929 811 8.7121210063878e-05 393 1.15621987436218 1.21282873660471 1 9.53605568612302 401 1009 1846 811 393 569 587 964 706 1710 1223 308 M16195 GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. 28/40 Gene Ontology BP GO:0014072 0.000957915964003045 0.00384571439215373 405 930.818181818182 812 8.7121210063878e-05 394 1.15621987436218 1.21282873660471 1 9.53605568612302 402 1010 1847 812 394 570 588 965 707 1720 1224 309 M10621 GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 54/68 Gene Ontology BP GO:0010718 0.0058975241681047 0.0136699157380001 90 1432.81818181818 813 0.000537581200614222 89 1.23939959277221 1.30185426063032 1 7.88892138618478 89 2143 813 1950 4061 625 521 582 3554 1279 144 310 M14490 GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 37/45 Gene Ontology BP GO:0035412 0.00698096701304944 0.0155791076794816 115 1286 815 0.000636656154192747 115 1.03916557326066 1.13582303046271 1 6.41096672695259 115 1623 2512 3339 815 140 239 558 1420 3166 219 311 M12714 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. 142/177 Gene Ontology BP GO:0017015 0.00229908307201748 0.00717961982154183 425 1241.63636363636 817 0.000209226292881999 141 1.30745738124459 1.30328688499257 1 9.57283818813303 422 2545 589 3246 1423 141 692 880 2732 817 171 312 M14890 GO_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTHENED_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. 67/88 Gene Ontology BP GO:0007224 0.00162330965465555 0.00567061548281701 865 1016.63636363636 817 0.000147682607430939 30 1.01751282983734 -0.90964498597907 -1 7.80405979917275 863 111 2576 87 1986 30 676 1439 817 2287 311 313 M11657 GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 77/129 Gene Ontology BP GO:0045428 0.000778495717199842 0.0033386524265847 825 919.363636363636 818 7.07973939601338e-05 325 1.18559575063418 1.35034494529863 1 10.0275153333866 824 818 673 658 1866 595 1038 589 1336 325 1391 314 M13980 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 142/177 Gene Ontology BP GO:1903844 0.00229908307201748 0.00717961982154183 425 1238.45454545455 818 0.000209226292881999 142 1.30745738124459 1.30328688499257 1 9.57283818813303 423 2546 590 3247 1424 142 693 835 2733 818 172 315 M16573 GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. 24/31 Gene Ontology BP GO:0032331 0.000525335317455643 0.00250449306569786 650 1000.72727272727 819 4.7769163962554e-05 111 1.25138307465754 1.36115445014465 1 11.1186878474954 647 2248 1082 1584 382 500 819 111 2456 999 180 316 M13197 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 71/84 Gene Ontology BP GO:2001239 0.00094097586602593 0.00379549992563795 40 1497.18181818182 820 8.55798707190877e-05 10 1.17002977697238 1.19586289855958 1 9.67291549737448 39 3691 704 3882 820 10 146 1429 4021 1668 59 317 M14401 GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. 40/71 Gene Ontology BP GO:0042304 0.000314519440911808 0.0017632035645333 1315 1229.63636363636 821 2.85967649705962e-05 128 0.902203289673748 1.03282997817718 1 8.48335298690343 1311 929 2652 808 234 578 348 128 2382 3335 821 318 M15541 GO_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_STORAGE.html The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 29/37 Gene Ontology BP GO:0019915 0.000876666139967843 0.00361278190941396 2460 1484.90909090909 822 7.97286975403984e-05 76 1.44663524166138 1.5083672514145 1 12.0681781659091 2459 279 604 76 822 3671 2667 2949 437 333 2037 319 M16450 GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. 17/19 Gene Ontology BP GO:1900119 0.00220309671305426 0.00695455156434291 770 967.727272727273 822 0.000200482364438923 164 1.4398187319266 1.48487168605528 1 10.6111223733162 769 1128 1510 164 534 269 822 1147 1910 2046 346 320 M12846 GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. 51/60 Gene Ontology BP GO:0042398 0.0185203489089154 0.0334660906691973 315 998.636363636364 824 0.00169801110331777 172 1.18518967148577 -1.0631528869938 -1 5.96778706806881 313 172 1593 468 1570 293 824 1943 748 1659 1402 321 M15446 GO_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRINOLYSIS.html A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. 18/29 Gene Ontology BP GO:0042730 1.56735665063496e-05 0.000183512676763213 335 1243.72727272727 825 1.42487983376473e-06 38 2.39044381188352 -2.76759766399162 -1 30.5256532241781 335 1124 320 2482 38 825 2130 2623 2763 273 768 322 M15627 GO_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 21/45 Gene Ontology BP GO:0050704 5.51695834002351e-05 0.000483435163015619 1145 862.636363636364 826 5.01554244918641e-06 19 1.67355121115332 1.88710063832955 1 18.960836138281 1144 1712 826 1302 473 663 1241 19 329 542 1238 323 M10631 GO_CARDIAC_CHAMBER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_MORPHOGENESIS.html The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. 133/183 Gene Ontology BP GO:0003206 6.33756138937113e-05 0.000535184630576114 255 1282.36363636364 827 5.76158542134681e-06 6 1.33839362094318 1.35147624338059 1 14.9593688704772 253 2981 323 3146 1931 236 574 1034 2795 827 6 324 M10825 GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. 17/22 Gene Ontology BP GO:0034114 0.00178102704235447 0.0060428429119702 945 961.090909090909 827 0.000162042774806517 354 1.61461768335066 -1.54233017690741 -1 12.2375351367591 941 1759 899 827 491 354 431 2461 539 503 1367 325 M15524 GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. 79/105 Gene Ontology BP GO:0007422 0.00309972348103869 0.00897412442079353 280 990.363636363636 827 0.00028219086527316 103 1.18781843408005 1.18608870586337 1 8.30241802010467 277 827 1331 1894 1267 123 103 441 2328 2089 214 326 M15691 GO_POSITIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_STORAGE.html Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 24/29 Gene Ontology BP GO:0010884 0.00181186198489895 0.00609587405331511 75 1128.54545454545 827 0.000164850537221235 73 1.3631236161978 1.38691219957646 1 10.3120616930214 73 2779 1716 2563 495 309 260 827 1884 998 510 327 M14540 GO_RESPONSE_TO_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 544/708 Gene Ontology BP GO:0070848 0.00257743716821166 0.00781290888839665 485 1690.63636363636 828 0.000258043148928877 102 1.19134024236356 1.21615738016501 1 8.57218398815501 483 2455 4500 2892 2777 102 828 824 2679 415 642 328 M11135 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 74/148 Gene Ontology BP GO:0003073 3.76595169457052e-07 7.45658435524962e-06 1425 1198.63636363636 831 3.42359303565896e-08 179 1.4155031026184 1.31788243572751 1 24.8038372788887 1425 831 179 729 2119 2779 1871 193 2126 345 588 329 M15608 GO_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_GUIDANCE.html The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. 211/347 Gene Ontology BP GO:0097485 9.97184870575783e-07 1.70586205703556e-05 525 1592.90909090909 832 9.06532111423563e-08 206 1.36119471733281 1.3143130123103 1 22.1791699489161 521 3636 206 3700 3522 513 832 809 2607 300 876 330 M16926 GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 40/56 Gene Ontology BP GO:0002312 0.00358263655149769 0.00998545461811565 835 1074.90909090909 832 0.000326225827977764 157 1.06432323814534 0.964910861370861 1 7.26936789590495 832 223 2099 653 2662 968 157 359 708 1928 1235 331 M11700 GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. 17/33 Gene Ontology BP GO:0002675 0.000482075715972193 0.00236863601522557 835 1157.81818181818 835 4.38346712170849e-05 290 1.77724284531724 1.67646995340928 1 15.9426724709482 835 1752 613 1246 290 764 872 391 3955 504 1514 332 M12560 GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. 303/340 Gene Ontology BP GO:0051056 0.00987882455233607 0.0204203334704663 345 1081.90909090909 835 0.000902133187650655 208 1.1351764247222 1.12850233067693 1 6.5481667184799 345 1367 792 713 2064 208 835 1019 2584 587 1387 333 M12516 GO_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_PROLIFERATION.html The expansion of a leukocyte population by cell division. 71/127 Gene Ontology BP GO:0070661 0.00803756867730456 0.0174272167080606 560 1116.63636363636 836 0.00073337132124137 199 1.25114179288253 1.28569234901789 1 7.51263905288298 556 833 836 1314 1653 482 199 897 3605 638 1270 334 M11158 GO_L_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSPORT.html The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 42/67 Gene Ontology BP GO:0015807 0.00231544020603387 0.00722214136608806 4150 1616.36363636364 837 0.000210716430973823 200 1.25002063960118 -1.19484351177965 -1 9.14087377154773 4148 200 803 458 546 1998 2562 3100 499 837 2629 335 M12339 GO_REGULATION_OF_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_AGGREGATION.html Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. 21/26 Gene Ontology BP GO:0090330 0.00323903699713429 0.00926890476486215 395 1415.81818181818 838 0.000294892331829889 114 1.55639378374205 1.38211247454651 1 10.8072434754024 393 3158 629 3486 2439 680 114 838 2194 1091 552 336 M11678 GO_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a leukocyte. 147/448 Gene Ontology BP GO:0002443 0.00138850907956125 0.0050435072187342 320 1426.09090909091 839 0.000126307836270982 319 1.18918768794263 1.16238072722673 1 9.32949825214488 319 2022 534 2277 4146 334 493 1068 2947 708 839 337 M10785 GO_LOOP_OF_HENLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOOP_OF_HENLE_DEVELOPMENT.html The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. 10/16 Gene Ontology BP GO:0072070 0.00467253733845188 0.0119852900969221 145 923.909090909091 840 0.000425680987147604 142 1.35296043471369 1.25033646993906 1 8.87693369228829 633 1198 995 488 1854 330 142 2464 143 1076 840 338 M10077 GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. 57/69 Gene Ontology BP GO:0007528 0.000639146055211914 0.00291277825161708 55 1417.45454545455 841 5.81210741890669e-05 34 1.03253980685829 1.14471166254137 1 8.9408373433334 53 2631 1812 2728 327 280 515 841 3992 2379 34 339 M10252 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS.html The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. 62/67 Gene Ontology BP GO:0097031 3.45072237536595e-05 0.000335904000263133 10 1276.72727272727 842 3.13706954680539e-06 6 0.616197806558426 -0.605086618842841 -1 7.30772606694046 6 842 3918 953 508 262 222 820 892 4323 1298 340 M15543 GO_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. 162/196 Gene Ontology BP GO:0006643 0.00577426225782821 0.0134540021460564 720 1127.54545454545 842 0.000526315789473684 21 1.10008142473393 -0.956528316899027 -1 7.02695228466366 1622 720 1855 21 842 250 2073 2622 351 718 1329 341 M16883 GO_POSITIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIOGENESIS.html Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. 52/67 Gene Ontology BP GO:0014015 0.000876923643622892 0.00361278190941396 920 613.818181818182 842 7.97521256385444e-05 33 1.2389258136107 1.34782704992673 1 10.3338853302831 71 880 920 842 1008 66 33 236 1650 917 129 342 M10716 GO_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROPTOTIC_PROCESS.html A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. 33/46 Gene Ontology BP GO:0070266 0.00275926690463483 0.00821424754143688 630 1129.63636363636 843 0.000251157609072325 92 1.18840444751421 1.04662400429089 1 8.46264077749284 629 264 1798 840 3806 324 92 1254 843 1404 1172 343 M10042 GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL.html A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. 39/78 Gene Ontology BP GO:0097553 0.00656630860223681 0.0148459834432497 680 1285.45454545455 844 0.00059872629598752 216 1.02565267194651 1.04085799526384 1 6.40086926382465 679 216 1333 798 2801 844 699 523 4059 902 1286 344 M12132 GO_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGING.html A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). 324/435 Gene Ontology BP GO:0007568 3.07147684880441e-06 4.61018767015707e-05 545 1099.72727272727 844 2.79225557907363e-07 231 1.23423597071349 1.26859400913588 1 18.2875247647628 542 1364 231 1308 2414 508 844 2314 1585 332 655 345 M13100 GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. 106/171 Gene Ontology BP GO:0050709 0.00663647046533783 0.0149392825714644 330 1194.81818181818 844 0.000605143168102455 111 1.24536366576744 1.28260125465366 1 7.76273605026149 330 2056 774 2018 2924 111 403 844 2072 630 981 346 M16606 GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL.html The directed movement of calcium ion into a cytosol. 39/78 Gene Ontology BP GO:1902656 0.00635901508624559 0.0145041652923043 680 1285.09090909091 845 0.000579770027176609 217 1.02565267194651 1.04085799526384 1 6.43634337232132 680 217 1334 799 2802 845 700 506 4060 906 1287 347 M12334 GO_FATTY_ACID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. 17/37 Gene Ontology BP GO:0055089 0.000580250639585655 0.00270840113049244 1610 1079.81818181818 846 5.27639761268135e-05 25 1.13391600711401 1.09837230193019 1 9.94219340898675 1607 397 1762 325 313 846 780 3402 25 1479 942 348 M10713 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN.html The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. 25/37 Gene Ontology BP GO:0050965 0.0030497020963657 0.00886337529943135 730 1122.63636363636 848 0.000277630718389582 263 1.51436250297076 1.40752729998058 1 10.6156954966124 726 327 848 405 1976 2263 1137 1728 263 422 2254 349 M11117 GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. 14/18 Gene Ontology BP GO:0045820 0.000913446831183754 0.00371851977733859 850 1072.81818181818 848 8.30751197956653e-05 101 1.08182435570172 -1.14683810768381 -1 8.97581072162528 848 1802 2357 1880 388 276 973 568 396 2212 101 350 M11729 GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. 84/110 Gene Ontology BP GO:0033238 0.0208659451433219 0.0367205910559291 270 1281.45454545455 848 0.00191513790867891 61 0.900639309671372 -0.748598033848369 -1 4.40832254976256 268 61 2919 496 1712 316 517 2480 848 3056 1423 351 M12333 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 158/210 Gene Ontology BP GO:0090288 0.000945830251597632 0.00380794235610993 315 1293.90909090909 848 8.60215573223041e-05 87 1.26094470684135 1.23313071674932 1 10.4192317462154 315 2015 498 2398 3682 87 848 1044 2601 635 110 352 M13411 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. 62/67 Gene Ontology BP GO:0032981 3.45072237536595e-05 0.000335904000263133 10 1280.27272727273 849 3.13706954680539e-06 7 0.616197806558426 -0.605086618842841 -1 7.30772606694046 7 843 3919 954 509 263 223 849 893 4324 1299 353 M14564 GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 14/18 Gene Ontology BP GO:0051198 0.000913446831183754 0.00371851977733859 850 1070.63636363636 849 8.30751197956653e-05 102 1.08182435570172 -1.14683810768381 -1 8.97581072162528 849 1803 2358 1881 389 277 974 525 397 2222 102 354 M15576 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. 25/37 Gene Ontology BP GO:0050961 0.0030497020963657 0.00886337529943135 730 1128 849 0.000277630718389582 264 1.51436250297076 1.40752729998058 1 10.6156954966124 727 328 849 406 1977 2264 1138 1777 264 423 2255 355 M11455 GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 26/28 Gene Ontology BP GO:0033014 3.71256051011381e-05 0.000352541715378767 340 1408.63636363636 850 3.37511196552157e-06 85 0.678671897303514 -0.7104372758337 -1 8.00099492628918 340 343 3757 1044 85 528 850 2032 688 4155 1673 356 M15248 GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 14/18 Gene Ontology BP GO:0051195 0.000913446831183754 0.00371851977733859 850 1075.27272727273 850 8.30751197956653e-05 103 1.08182435570172 -1.14683810768381 -1 8.97581072162528 850 1804 2359 1882 390 278 975 564 398 2225 103 357 M14158 GO_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. 132/157 Gene Ontology BP GO:0045444 0.00416560919094257 0.0110928478086586 325 1132.90909090909 851 0.000379410688348057 6 1.08184663762621 1.14830207907 1 7.22028651838968 323 6 1380 2279 679 170 379 1247 3080 2068 851 358 M13347 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. 37/78 Gene Ontology BP GO:0032732 0.000338798557610417 0.00186119207622346 855 987.545454545455 853 3.08046130561603e-05 78 1.64367184522093 1.75456970898448 1 15.332093883859 853 256 504 1364 623 1817 1435 78 1177 611 2145 359 M16265 GO_RESPONSE_TO_MISFOLDED_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MISFOLDED_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. 16/17 Gene Ontology BP GO:0051788 0.000252912866917449 0.00149340554538945 855 1608.09090909091 855 2.29947224146008e-05 65 0.581394744684803 -0.531793635877057 -1 5.60638814068529 855 3195 3865 2701 212 65 116 181 1437 4630 432 360 M11551 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. 42/70 Gene Ontology BP GO:0003333 0.00471680023606286 0.0120589403837365 3240 2204.45454545455 860 0.000429722137766529 196 1.25096664017492 1.38562827955487 1 8.19555715844578 3237 196 703 696 720 4000 4634 3966 860 838 4399 361 M11243 GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of vacuolar transport. 21/23 Gene Ontology BP GO:1903337 0.00038461236127402 0.00201078799663822 1860 1253 861 3.49708742845852e-05 95 0.962134509161756 -0.630278249602229 -1 8.85987951816488 1860 417 3215 1401 266 861 456 549 95 3374 1289 362 M13718 GO_CARDIAC_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 139/191 Gene Ontology BP GO:0003231 0.00014228298034826 0.000985182600536388 1435 1065.45454545455 862 1.29356530184242e-05 4 1.33839982830654 1.39164215276 1 13.7467599289548 353 1432 372 1930 1433 637 1527 736 2434 862 4 363 M11204 GO_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_PROLIFERATION.html The expansion of a B cell population by cell division. Follows B cell activation. 19/53 Gene Ontology BP GO:0042100 0.00167468279811514 0.00579891218238557 805 1096.09090909091 864 0.000152359905405585 59 1.47194667943156 1.69855698475271 1 11.2453142825175 804 1091 864 898 3016 338 59 555 3244 885 303 364 M15224 GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. 41/42 Gene Ontology BP GO:0061298 9.3923948889067e-05 0.000710614852326551 40 1440.18181818182 864 8.53890536328222e-06 40 1.39007581156598 1.45683550501709 1 14.9522477645774 40 2681 351 3441 1624 852 864 927 3607 806 649 365 M11136 GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of smooth muscle contraction. 54/84 Gene Ontology BP GO:0006940 2.58372240515655e-08 7.56104424603361e-07 540 917.363636363636 869 2.34883857772753e-09 119 1.48028398940295 1.37268550469142 1 30.9699148783146 540 869 119 1731 262 466 1269 1175 1769 210 1681 366 M11662 GO_TRANSLATIONAL_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_TERMINATION.html The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). 92/100 Gene Ontology BP GO:0006415 0.00145226860756106 0.00519400909375988 25 1651.54545454545 869 0.000132111651733805 22 0.591258539986942 -0.582192919531285 -1 4.60740705035438 22 796 4167 1573 811 869 661 1894 747 4483 2144 367 M12842 GO_CILIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MORPHOGENESIS.html A process that is carried out at the cellular level and in which the structure of a cilium is organized. 238/309 Gene Ontology BP GO:0060271 0.00370213811685457 0.0102050051289836 740 1285.09090909091 870 0.000337125704981307 36 1.05970686926774 -1.09146397478332 -1 7.20357026894774 736 668 2427 36 4600 63 901 1183 870 2399 253 368 M11227 GO_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DIFFERENTIATION.html The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. 179/262 Gene Ontology BP GO:0001649 9.32685878290436e-06 0.000121223111499592 245 1479.63636363636 872 8.47899847652921e-07 237 1.31860255092339 1.37425390318983 1 17.6454456578921 241 3296 255 3364 3033 973 843 534 2628 872 237 369 M13352 GO_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULUS_DEVELOPMENT.html The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. 74/90 Gene Ontology BP GO:0032835 1.76905616509792e-07 3.90114613090076e-06 875 1570.45454545455 873 1.60823300668241e-08 70 1.39110680664495 1.38213667080461 1 25.7142813944127 70 3018 160 3299 3132 873 775 872 3474 606 996 370 M12269 GO_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION.html The movement of a leukocyte within or between different tissues and organs of the body. 241/380 Gene Ontology BP GO:0050900 1.74956166341629e-16 5.42714027991734e-14 180 1233.45454545455 876 1.59051060310572e-17 10 1.408656976868 1.39526040965193 1 63.8772891017131 176 1957 10 1725 3645 364 876 392 2940 85 1398 371 M15823 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein. 16/25 Gene Ontology BP GO:0042523 0.00577426225782821 0.0134540021460564 495 1166.81818181818 876 0.000526315789473684 239 1.05938519152536 1.2277313157871 1 6.76660389980915 492 471 2112 239 2288 876 649 613 1427 1899 1769 372 M10674 GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 47/65 Gene Ontology BP GO:0009247 0.00169869002066521 0.00583839042088994 705 1206.63636363636 878 0.000154545732080207 100 1.02944878513633 -0.760118377822607 -1 7.8511617051042 702 895 2573 956 484 100 471 2433 878 3037 744 373 M13532 GO_TETRAPYRROLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 51/86 Gene Ontology BP GO:0033013 0.00577426225782821 0.0134540021460564 200 1049.90909090909 878 0.000526315789473684 119 0.924973746200851 -0.969404472962775 -1 5.90672572590425 200 179 3094 119 888 315 878 634 1131 3220 891 374 M14241 GO_RESPONSE_TO_BMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 97/151 Gene Ontology BP GO:0071772 7.90447350107471e-05 0.000625501959192187 80 1345.90909090909 878 7.18614319868098e-06 80 1.37588822271635 1.35819965125372 1 15.0601641115255 80 2580 340 2583 2370 605 796 1148 3226 878 199 375 M13023 GO_VITAMIN_D_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). 11/25 Gene Ontology BP GO:0042359 0.00888431744642479 0.018807429061972 3140 1645 879 0.000810945397994597 249 1.83103679776963 -1.57513334430426 -1 10.7924120144451 3138 515 819 618 879 2822 3881 3656 286 1232 249 376 M14664 GO_CELLULAR_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 97/139 Gene Ontology BP GO:1901655 0.0136229565697306 0.0262204536414665 700 1143.81818181818 879 0.00124618654443371 57 1.11541672615103 1.22286737806258 1 6.01993365554088 700 57 998 2111 1463 441 362 739 3180 879 1652 377 M15064 GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. 62/67 Gene Ontology BP GO:0010257 3.45072237536595e-05 0.000335904000263133 10 1283.90909090909 879 3.13706954680539e-06 8 0.616197806558426 -0.605086618842841 -1 7.30772606694046 8 844 3920 955 510 264 224 879 894 4325 1300 378 M15778 GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 97/151 Gene Ontology BP GO:0071773 7.90447350107471e-05 0.000625501959192187 2585 1343.45454545455 881 7.18614319868098e-06 81 1.37588822271635 1.35819965125372 1 15.0601641115255 81 2581 341 2584 2371 606 797 1109 3227 881 200 379 M16014 GO_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIOGENESIS.html Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. 98/139 Gene Ontology BP GO:0014013 0.00204517628186235 0.00660631792704992 230 987.181818181818 883 0.000186098182560903 65 1.34285404397454 1.3534519626264 1 9.99822449296092 229 1474 883 1419 3312 73 178 498 1791 937 65 380 M16700 GO_RESPONSE_TO_MONOAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MONOAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. 53/70 Gene Ontology BP GO:0071867 0.00125990258999556 0.00470119153885569 105 1328.27272727273 883 0.000114602244891121 21 1.16689948203097 1.25236162929764 1 9.27622178623641 102 883 1745 3771 3093 21 100 228 3081 1219 368 381 M16162 GO_ACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase (MAPK). 157/224 Gene Ontology BP GO:0000187 0.00472418726207473 0.0120645682384378 640 1220.45454545455 884 0.000430396580482995 339 1.23073671574828 1.24286798648228 1 8.06199815836614 640 1421 682 884 4030 339 509 1040 2200 624 1056 382 M12438 GO_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 142/203 Gene Ontology BP GO:0043279 0.0010109563487918 0.00401021303574445 495 1355.18181818182 885 9.19473825650925e-05 495 1.13463616221342 1.21344479073587 1 9.28727712386928 495 1430 502 1290 4238 626 885 801 2989 1108 543 383 M13189 GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of stem cell differentiation. 71/92 Gene Ontology BP GO:2000738 0.000931260115530872 0.00377123874461719 110 1500.09090909091 885 8.46958683415732e-05 110 1.25092516884473 1.31386891165025 1 10.3543450819217 110 3019 885 2466 4551 254 446 170 3265 1199 136 384 M16813 GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS.html The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. 228/356 Gene Ontology BP GO:0045137 0.00454197447648817 0.0117410040217219 860 1378.09090909091 885 0.0004137617026693 533 1.25992960477397 1.17808678397965 1 8.3043387289401 859 2509 675 3006 1407 597 533 1681 2247 760 885 385 M16170 GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. 55/62 Gene Ontology BP GO:0060603 5.46153032338488e-05 0.000481297359748292 4490 1682.45454545455 886 4.96515082849123e-06 155 1.40987137368647 -1.52346248726076 -1 15.9810200828876 4488 155 319 235 1708 4190 3696 886 864 282 1684 386 M12119 GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 139/217 Gene Ontology BP GO:0046890 0.00492072700345569 0.01245709616272 890 1302.81818181818 887 0.000448342522970087 332 1.13491791012723 1.14269660830847 1 7.37954781464452 887 746 685 1230 2055 332 546 3606 2269 861 1114 387 M14462 GO_CELLULAR_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 19/28 Gene Ontology BP GO:0071467 3.60465354698393e-05 0.00034511220070198 1705 1122.81818181818 887 3.27701146347819e-06 81 1.0132159761882 1.26041310711729 1 11.9823001032582 1705 393 2411 525 81 1696 1552 887 119 2249 733 388 M15987 GO_O_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_GLYCAN_PROCESSING.html The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. 40/65 Gene Ontology BP GO:0016266 5.68716359940236e-08 1.52082599011604e-06 2485 1722.36363636364 887 5.17014886038162e-09 125 1.63326793708554 1.55338701914456 1 32.4769376059521 2482 198 129 250 392 4218 2451 3301 887 125 4513 389 M11430 GO_RESPONSE_TO_AXON_INJURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AXON_INJURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. 53/74 Gene Ontology BP GO:0048678 0.015381672766408 0.0288930771786948 2695 1740.45454545455 888 0.00140820735726169 337 1.63002537367105 -1.54549161437262 -1 8.56728876529457 2693 888 865 619 4376 3033 2255 774 337 784 2521 390 M14574 GO_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT.html The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 158/290 Gene Ontology BP GO:0045165 8.82475472382903e-10 3.73287124817968e-08 1335 1248.81818181818 888 8.02250429760804e-11 53 1.30929720400647 1.33337074886902 1 33.2399794668927 1332 725 80 63 3180 666 888 4141 1011 53 1598 391 M15092 GO_PROSTATE_GLAND_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_GROWTH.html The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. 14/17 Gene Ontology BP GO:0060736 2.88218284610595e-05 0.000296044079093399 3970 1714.81818181818 888 2.62020055071748e-06 68 1.56167993353738 1.420638372699 1 18.829829506125 3969 479 888 163 68 2625 2182 3870 292 510 3817 392 M12723 GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 215/303 Gene Ontology BP GO:0050730 4.76390788933651e-06 6.71711012396448e-05 490 1025.81818181818 889 4.33083473199484e-07 242 1.30088687387657 1.45918976586683 1 18.5486266203246 486 1970 242 856 1706 889 964 719 2129 296 1027 393 M14062 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 46/74 Gene Ontology BP GO:0010524 0.00114109120618507 0.00434492420816622 3960 1689.90909090909 889 0.000103789408638182 415 1.21935864073702 -1.35042690274552 -1 9.83640764929199 3958 889 820 515 415 2651 3734 761 485 1062 3299 394 M10479 GO_VENTRICULAR_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_MORPHOGENESIS.html The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. 38/43 Gene Ontology BP GO:0060412 0.0173656722976615 0.0317796713332286 645 1200.45454545455 891 0.00159129838325057 229 1.46579566256763 1.44483271233383 1 7.49578294792326 641 229 891 646 4474 452 990 2437 284 1114 1047 395 M14259 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. 27/47 Gene Ontology BP GO:0010574 0.00148321331176652 0.00528595254676769 525 1072.09090909091 891 0.000134928565548832 392 1.34645065396131 1.44170818654732 1 10.4708116878746 523 990 539 1199 2718 891 392 1334 1878 679 650 396 M15201 GO_MATURE_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION.html The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. 21/24 Gene Ontology BP GO:0002335 0.0214817964451604 0.0375487599020779 1705 1462.63636363636 891 0.00197222431276913 308 1.15148126468938 1.03639388890242 1 5.60094607585592 1703 367 1722 588 4336 2918 606 891 308 1943 707 397 M11201 GO_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DETERMINATION.html Any process that establishes and transmits the specification of sexual status of an individual organism. 12/29 Gene Ontology BP GO:0007530 0.00952805583530693 0.019961428181669 895 1125 893 0.000869961197483976 240 1.56974107829319 1.2756824364062 1 9.11197456890782 985 1190 1637 864 893 240 255 3167 298 1953 893 398 M12368 GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. 48/79 Gene Ontology BP GO:1903018 0.00685726171349886 0.0153545903526998 1510 1056.90909090909 893 0.000625339009395058 369 1.19613506681485 1.35495919803022 1 7.40675745628757 1510 893 1992 369 977 791 674 532 1254 1792 842 399 M11074 GO_CELLULAR_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. 44/63 Gene Ontology BP GO:0006879 0.0143522019454485 0.02733556923953 450 843.272727272727 894 0.00131333599807064 348 1.22669701392031 1.21415127458397 1 6.54571912774835 449 901 1531 1197 1183 567 894 950 348 580 676 400 M10095 GO_REGULATION_OF_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_BURST.html Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 12/20 Gene Ontology BP GO:0060263 0.0133128744894705 0.0257393417227517 900 1523.27272727273 899 0.00121764763136543 274 1.40103816749896 1.35063976991508 1 7.602695981199 899 2877 2288 3055 2858 489 346 898 820 1952 274 401 M12776 GO_EMBRYONIC_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_MORPHOGENESIS.html Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 283/440 Gene Ontology BP GO:0048562 5.40085702589039e-08 1.46105742682953e-06 515 1088.81818181818 899 4.90987014407083e-09 128 1.24867596445568 1.2930518549528 1 24.9012912088292 514 1944 128 1018 3216 197 899 1629 2053 225 154 402 M16727 GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. 19/19 Gene Ontology BP GO:0006515 0.00373134503588767 0.0102672669733798 905 2008 901 0.000339789882835157 127 0.531793635877057 -0.531793635877057 -1 3.60485925631067 901 3860 4014 3668 649 237 127 388 3101 4648 495 403 M10244 GO_REGULATION_OF_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULOGENESIS.html Any process that modulates the frequency, rate or extent of vasculogenesis. 16/21 Gene Ontology BP GO:2001212 0.000109862364992268 0.000806292719730322 255 1039.81818181818 902 9.98798651099685e-06 144 1.9882496156035 2.0716012459592 1 21.018135971205 251 2832 1206 2793 144 446 161 602 1145 956 902 404 M14116 GO_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_MIGRATION.html The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. 45/59 Gene Ontology BP GO:0008347 0.000243990740678268 0.00146300118089688 790 1192.63636363636 903 2.21834367858938e-05 64 1.52115010178322 1.6822205182353 1 14.732140430404 788 2164 1411 912 3882 590 711 64 903 1295 399 405 M16415 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 42/54 Gene Ontology BP GO:0044246 0.00137398675740305 0.00499950730935871 120 1110.90909090909 904 0.000124985965214455 118 1.40572063780377 1.34159570562155 1 11.0484884491096 118 1595 533 1317 911 904 613 487 3740 1106 896 406 M15580 GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. 42/53 Gene Ontology BP GO:0000096 0.00343937044456975 0.00971079531467417 410 1176 906 0.000313159925729381 224 1.14797345447797 -1.29336434089136 -1 7.88908207107351 408 224 2942 1075 906 474 1141 348 834 3411 1173 407 M13383 GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. 20/24 Gene Ontology BP GO:0031954 0.00359415150739297 0.00999246212739869 330 1965.45454545455 907 0.000327276068780375 113 0.86426877411471 0.90197548482549 1 5.9000838813015 326 3830 3022 3738 795 377 113 678 4138 3696 907 408 M10667 GO_MEMBRANE_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. 36/45 Gene Ontology BP GO:0044091 0.00647274987945214 0.0146653042036169 545 1259.45454545455 912 0.00059017023202077 191 1.07931878533729 -1.06046835931072 -1 6.75596915674294 545 253 1935 1016 3594 191 912 513 1499 3109 287 409 M14224 GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. 70/74 Gene Ontology BP GO:0007044 0.000277753360459158 0.00161145434690332 1960 1338.81818181818 912 2.52534939495055e-05 413 1.44853141610745 1.44970848097003 1 13.8204579654344 1957 839 413 482 1817 2478 2817 546 2050 416 912 410 M16710 GO_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 154/182 Gene Ontology BP GO:0042542 0.0102633131813853 0.0211000020689681 1425 1335 913 0.000937409824007804 573 1.04999497198877 1.03675173656068 1 6.00495792074976 793 1425 1423 2462 913 573 596 859 3008 1876 757 411 M11061 GO_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease. 10/54 Gene Ontology BP GO:0042737 0.00532670099683769 0.0131906012444309 500 1811.63636363636 915 0.000485422003707331 156 1.99226326390203 -2.09780835281195 -1 12.7930483574265 499 3929 737 2795 3991 838 156 1273 4127 668 915 412 M11111 GO_LYMPH_NODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_NODE_DEVELOPMENT.html The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. 11/17 Gene Ontology BP GO:0048535 0.00367323563252904 0.0101592463568013 950 941.454545454545 915 0.000334489366750006 156 1.63791793258208 1.79662947510679 1 11.1508236685454 950 1845 2076 828 1300 915 237 369 450 1230 156 413 M12357 GO_DETECTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS.html The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. 31/46 Gene Ontology BP GO:0016048 0.015744482853263 0.0293977041397402 915 1153.36363636364 915 0.00144166377942898 281 1.45561268904041 1.40752729998058 1 7.61202551238672 915 281 868 838 1073 2277 1270 1363 573 689 2540 414 M13058 GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. 42/62 Gene Ontology BP GO:0032007 0.00402552220764091 0.0108521175157318 1565 1307 915 0.000366627905769221 399 0.970271416269146 0.961963580168056 1 6.50613864205197 1561 915 3164 1388 667 1481 665 399 432 3087 618 415 M11211 GO_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. 178/263 Gene Ontology BP GO:0042593 0.0104540357220119 0.021376669480072 565 1176.18181818182 917 0.000954913143091055 176 1.04404729972243 1.13023727078075 1 5.95068772945032 564 1997 1966 1812 917 176 527 740 2078 1559 602 416 M13634 GO_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_SORTING_PATHWAY.html A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. 12/12 Gene Ontology BP GO:0071985 0.00103075486002724 0.00406105195910816 385 1562.09090909091 918 9.37489192176012e-05 119 0.862556236951535 -0.862556236951535 -1 7.04154442380791 384 3236 3493 3057 588 258 1188 184 918 3758 119 417 M14445 GO_CARBOHYDRATE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. 178/263 Gene Ontology BP GO:0033500 0.0104540357220119 0.021376669480072 565 1169.63636363636 918 0.000954913143091055 177 1.04404729972243 1.13023727078075 1 5.95068772945032 565 1998 1967 1813 918 177 528 657 2079 1561 603 418 M11056 GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION.html The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. 10/18 Gene Ontology BP GO:0048505 0.00109104158829534 0.00421996384899269 380 1364.18181818182 919 9.92348220300673e-05 41 1.19651888697583 1.19651888697583 1 9.70380769631695 377 3254 2408 2207 2677 193 41 451 919 2312 167 419 M14459 GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. 74/106 Gene Ontology BP GO:0046888 0.00959944015991358 0.0200386698358358 690 1638.63636363636 919 0.000876507623065676 164 1.21076906062148 1.2009478326526 1 7.01884559559156 686 2113 919 3064 2767 164 361 2938 3495 607 911 420 M14964 GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC.html Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. 10/18 Gene Ontology BP GO:0040034 0.00109104158829534 0.00421996384899269 380 1364.72727272727 920 9.92348220300673e-05 42 1.19651888697583 1.19651888697583 1 9.70380769631695 378 3255 2409 2208 2678 194 42 438 920 2322 168 421 M13317 GO_GLYCOPROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 22/29 Gene Ontology BP GO:0006516 0.000198145971670146 0.00125609428635039 4415 1754 921 1.80148927459405e-05 189 1.26400277061857 -1.33015295534216 -1 12.5260837014644 4411 351 921 274 189 3491 2557 3750 637 436 2277 422 M12651 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate, or extent of leukocyte migration. 92/148 Gene Ontology BP GO:0002687 1.56732933890574e-06 2.53221646316959e-05 515 1412 924 1.42484586864312e-07 218 1.40317728037604 1.41654544264736 1 22.0405331538877 515 2588 218 2003 3221 402 670 1145 3481 365 924 423 M15980 GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. 61/73 Gene Ontology BP GO:0051057 0.000599303085712838 0.00277192570360024 105 1478.45454545455 925 5.44969458592004e-05 104 1.28304123575893 1.2545409736914 1 11.2069606303287 104 3034 461 2720 889 228 181 2937 3628 1156 925 424 M16892 GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. 14/20 Gene Ontology BP GO:0042789 0.00356335267954073 0.00995214887028993 250 1448.72727272727 927 0.000324467034908814 126 1.08187299142374 1.09442294690297 1 7.39477616831535 246 2848 2302 2877 927 587 126 357 2794 2227 645 425 M10203 GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT.html The directed movement of substances from endoplasmic reticulum to cytosol. 24/32 Gene Ontology BP GO:1903513 0.000328048112602714 0.00181931807859408 990 1436.45454545455 928 2.98270035438476e-05 240 0.931428365266919 -0.915179618780508 -1 8.7151707376336 986 2755 3559 632 240 840 499 1228 609 3525 928 426 M13132 GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. 241/319 Gene Ontology BP GO:0043523 0.0409897505025902 0.0634060203086943 930 1193.36363636364 929 0.00379763580543812 445 1.18485744753731 1.21914482739044 1 4.84186502110367 929 1383 2044 445 2088 544 576 1502 853 900 1863 427 M14124 GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. 30/30 Gene Ontology BP GO:0032469 0.000132404150520266 0.00093628649296474 940 1122.36363636364 929 1.20374654330952e-05 136 0.970260551264471 -0.877879182843065 -1 10.035991437972 936 274 2317 136 154 883 1748 2892 588 1489 929 428 M15744 GO_NEUROMUSCULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS.html Any process pertaining to the functions of the nervous and muscular systems of an organism. 107/199 Gene Ontology BP GO:0050905 8.42032143514731e-05 0.000652995927295674 935 1225.72727272727 932 7.65513066671447e-06 307 1.32839201319578 1.33996424975238 1 14.4550659973965 932 780 345 761 4054 1221 1971 1010 1624 478 307 429 M15881 GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 110/141 Gene Ontology BP GO:0007229 5.14735460515193e-06 7.10701512693529e-05 400 1081.18181818182 932 4.67942422590102e-07 33 1.26766537973876 1.31751171120549 1 17.968461734755 397 33 247 564 1923 1821 1560 932 2084 320 2012 430 M13407 GO_REGULATION_OF_FEVER_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEVER_GENERATION.html Any process that modulates the rate or extent of fever generation. 9/13 Gene Ontology BP GO:0031620 0.00191283422755075 0.00634384722793559 360 1668.63636363636 935 0.000191448274566975 232 1.7307572266684 1.43530744290725 1 12.9936247313302 356 2413 4425 2368 1844 376 232 277 4499 935 630 431 M14384 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that increases the amount of sodium excreted in urine over a unit of time. 9/17 Gene Ontology BP GO:0035815 0.00168735241990855 0.00582199348953458 480 1669 936 0.000168863501195615 253 1.55077419012294 1.60592575607802 1 11.8389613480088 479 2406 4489 2803 1074 592 483 253 4114 936 730 432 M10548 GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 26/33 Gene Ontology BP GO:0009261 0.000999522359160159 0.00397491411314166 3305 1433.63636363636 938 9.09069781410459e-05 41 1.54986174283501 -1.52784955176285 -1 12.7102492428929 3302 314 708 41 1943 938 2586 3386 326 342 1884 433 M12278 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C.html The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. 13/17 Gene Ontology BP GO:0006122 0.00294370549370639 0.00861764758525369 230 1550.18181818182 938 0.000267968337009618 228 0.594259130807792 -0.594259130807792 -1 4.18409200866001 228 1806 3732 1632 585 450 889 938 702 4505 1585 434 M13436 GO_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 127/188 Gene Ontology BP GO:0070555 0.00744418306460408 0.0163858585850115 150 1316.18181818182 938 0.000679044733455838 146 1.21622202973309 1.30172894598392 1 7.41392986081663 146 3311 1002 2687 1490 204 433 554 2921 938 792 435 M16320 GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 21/23 Gene Ontology BP GO:0046325 0.00560271557209327 0.0134540021460564 585 1003.63636363636 940 0.000510639547798409 368 1.15041463844 1.15892815077334 1 7.34895188658628 582 368 1289 415 1666 1783 940 473 981 1947 596 436 M16656 GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. 34/39 Gene Ontology BP GO:0014065 0.0570194543167219 0.0834111585649464 1665 1460.09090909091 942 0.00532302104692977 255 1.25767752751946 1.16919760571767 1 4.6280014372402 1665 255 1623 631 4046 878 942 1342 690 855 3134 437 M16783 GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 113/155 Gene Ontology BP GO:0010717 0.000579985827386535 0.00270840113049244 150 1314.18181818182 942 5.27398895874305e-05 122 1.20316437231567 1.2897835202969 1 10.5500153401049 149 2565 942 1954 4110 139 402 122 2997 950 126 438 M11803 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE.html Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. 72/118 Gene Ontology BP GO:0050885 0.000848541355916735 0.00353787000813671 1475 1432.90909090909 943 7.71698923342127e-05 487 1.29913392221438 1.30809276546185 1 10.8770182321694 1473 835 487 802 4486 1873 1759 943 1786 547 771 439 M12057 GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 90/106 Gene Ontology BP GO:0010812 7.92251092870015e-05 0.000625864912584751 185 976.909090909091 943 7.20254203990929e-06 71 1.35284421438938 1.5143820236838 1 14.8065857224138 182 1478 342 1300 1516 943 1442 263 2725 484 71 440 M14756 GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. 14/14 Gene Ontology BP GO:0046341 0.00253330813819662 0.00770097708978793 945 1536 943 0.000230566360296771 76 0.761248649662751 -0.81115823190148 -1 5.48995907417515 943 2346 3362 592 3102 76 87 694 1604 3367 723 441 M15452 GO_MONOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 197/276 Gene Ontology BP GO:0005996 0.00106124196516188 0.0041476540170951 3095 1671.72727272727 943 9.65231123569735e-05 23 1.04782268907375 -0.950559737770126 -1 8.52344214055569 3095 688 1389 23 406 652 2629 4536 811 943 3217 442 M10637 GO_SEROTONIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. 12/21 Gene Ontology BP GO:0042428 0.000255313306086304 0.00150376305470832 1895 1005.72727272727 944 2.32129945812738e-05 57 1.7242873832026 -1.89446049377984 -1 16.6305642265431 1892 1195 1156 730 2685 944 1693 65 70 576 57 443 M13001 GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. 37/48 Gene Ontology BP GO:2000171 0.00670869796757792 0.0150727048011299 1690 1505.45454545455 945 0.000611749390103898 164 1.15710064901781 1.27149815861972 1 7.19653356684951 1688 945 2314 869 4426 674 384 1782 879 2435 164 444 M13738 GO_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NIK_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). 94/119 Gene Ontology BP GO:0038061 0.0121288119510346 0.0239234260314387 870 1346.09090909091 945 0.00110874545093121 53 0.867333615987392 -0.817931625963105 -1 4.79672254347171 866 53 3507 411 966 628 1732 945 1043 3867 789 445 M10129 GO_SYNAPTIC_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_LOCALIZATION.html Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. 110/155 Gene Ontology BP GO:0097479 0.00344736714570284 0.009721575350882 2240 1261.90909090909 946 0.000313889181733201 286 1.20965594160366 -1.33406660785648 -1 8.31155545443047 2239 773 2562 321 625 1321 2904 946 333 1571 286 446 M16862 GO_ACUTE_PHASE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_PHASE_RESPONSE.html An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. 42/111 Gene Ontology BP GO:0006953 5.80172046903997e-06 7.9632464137e-05 470 929.545454545455 948 5.27430524461678e-07 157 1.72744147058023 1.68439320739493 1 24.1976278928243 157 1591 248 2271 1281 948 470 466 1103 402 1288 447 M13293 GO_ELECTRON_TRANSPORT_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_TRANSPORT_CHAIN.html A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 92/110 Gene Ontology BP GO:0022900 9.74108526346057e-07 1.68495426508855e-05 5 1355 949 8.85553597871625e-08 2 0.61853158815001 -0.609233503650556 -1 10.0838000319866 2 1463 4047 949 505 192 182 890 1038 4381 1256 448 M13988 GO_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_PROCESS.html A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 67/119 Gene Ontology BP GO:0022600 7.63649555170109e-07 1.38259197673405e-05 145 1589.90909090909 949 6.94227109312053e-08 95 1.57610348640393 1.49924103673941 1 26.1742657430888 145 3026 198 3465 4185 119 95 1699 3320 288 949 449 M14835 GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). 36/87 Gene Ontology BP GO:0007193 3.47187572654934e-05 0.000337257573186515 950 1331.18181818182 949 3.15630047119106e-06 2 1.21495588031373 1.13592559092539 1 14.4117337346884 1812 949 528 2742 1575 1380 793 947 3160 755 2 450 M14222 GO_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 312/453 Gene Ontology BP GO:0006066 4.59804437256305e-07 8.98936994350247e-06 3490 1713 950 4.1800412123308e-08 7 1.22270365192338 -1.17030132992466 -1 21.0845628594004 3488 635 181 7 601 2194 4026 4234 950 160 2367 451 M13631 GO_NEURON_PROJECTION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MORPHOGENESIS.html The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. 454/670 Gene Ontology BP GO:0048812 5.62941417849535e-09 1.8832402269781e-07 650 1345.09090909091 951 5.11764926627275e-10 103 1.28016519645335 1.29922480359777 1 29.4238472233475 649 2466 103 1762 3369 862 859 1401 1975 399 951 452 M13942 GO_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_MORPHOGENESIS.html The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. 535/783 Gene Ontology BP GO:0048598 7.96454814751614e-05 0.000628067476603573 450 1394.36363636364 951 7.9648336150382e-06 75 1.20542405934865 1.2027700992626 1 13.1856544215028 450 1912 4462 951 2673 78 862 1465 2192 218 75 453 M16160 GO_PROTEIN_INSERTION_INTO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_INSERTION_INTO_MEMBRANE.html The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. 22/30 Gene Ontology BP GO:0051205 0.0214372050881738 0.0375261521748725 710 1436.36363636364 951 0.00196808981533488 358 0.855122250128023 -0.814868404304334 -1 4.15743990775739 707 358 2501 1535 1229 519 399 3620 951 3423 558 454 M13740 GO_NEGATIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 188/307 Gene Ontology BP GO:0051048 7.89791514082775e-05 0.000625501959192187 245 1138.09090909091 953 7.18018062471444e-06 24 1.22410967730359 1.30308922837542 1 13.3976539312568 243 1986 339 997 4162 24 335 1086 2156 238 953 455 M11704 GO_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DIFFERENTIATION.html The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 94/108 Gene Ontology BP GO:0045446 0.0105291210893326 0.0214877194862563 375 929.818181818182 954 0.000961804848744826 56 1.2541228273748 1.28179939108607 1 7.1405381553913 374 56 797 1257 1641 789 434 993 1671 954 1262 456 M10645 GO_STEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. 55/94 Gene Ontology BP GO:0055092 9.24546319685532e-05 0.000702927128349147 2755 1506.54545454545 956 8.4053197806915e-06 105 1.5359045946057 -1.50987252708767 -1 16.5467693243768 2754 142 349 105 956 2257 4502 2455 1723 543 786 457 M12965 GO_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 72/83 Gene Ontology BP GO:0061383 0.000201879909494657 0.00127110584422008 90 1507.81818181818 957 1.83544033728385e-05 88 1.38267426861755 1.41162763167987 1 13.678711731442 88 3021 393 3665 2563 506 423 957 3753 1012 205 458 M13144 GO_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. 55/94 Gene Ontology BP GO:0042632 9.24546319685532e-05 0.000702927128349147 2755 1477.81818181818 957 8.4053197806915e-06 106 1.5359045946057 -1.50987252708767 -1 16.5467693243768 2755 143 350 106 957 2258 4503 2129 1724 544 787 459 M10781 GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. 83/97 Gene Ontology BP GO:0031145 0.00195241203841383 0.00641104466609068 25 1375.36363636364 958 0.000177649716533126 25 0.631377060373863 -0.61561940989133 -1 4.72339932223573 25 74 4108 637 958 348 437 1291 1589 4314 1348 460 M11993 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 23/33 Gene Ontology BP GO:0044253 0.000340018853601353 0.00186130320683188 1300 1143 958 3.0915583296106e-05 243 1.38075403402387 1.25925834742415 1 12.8777808744735 1299 370 958 412 243 1965 2796 1652 480 907 1491 461 M15499 GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS.html The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. 28/31 Gene Ontology BP GO:0035313 6.65246923978223e-05 0.000554730096285067 55 1426.81818181818 959 6.04788218996971e-06 51 1.45155742944292 1.36743736199142 1 16.1478034854005 51 2224 325 2419 1725 860 959 2261 3374 737 760 462 M16163 GO_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 407/596 Gene Ontology BP GO:0048568 5.33775377284527e-10 2.36538745762372e-08 620 982.181818181818 959 4.85250343103668e-11 75 1.23378280060662 1.2736516664753 1 32.1580360401977 616 1924 75 959 2604 82 1197 1264 1707 99 277 463 M16187 GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. 23/33 Gene Ontology BP GO:0010714 0.000340018853601353 0.00186130320683188 1300 1143 959 3.0915583296106e-05 244 1.38075403402387 1.25925834742415 1 12.8777808744735 1300 371 959 413 244 1966 2797 1636 481 914 1492 464 M10982 GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 33/54 Gene Ontology BP GO:0090184 0.00191504313177838 0.00634664935339374 1355 1217.27272727273 960 0.000174246560151188 564 1.48746725146285 1.53589796228324 1 11.1646559822238 1355 960 564 568 3396 1574 1015 1675 590 811 882 465 M15014 GO_CONNECTIVE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNECTIVE_TISSUE_DEVELOPMENT.html The progression of a connective tissue over time, from its formation to the mature structure. 206/273 Gene Ontology BP GO:0061448 6.42207928270368e-13 6.96956744281281e-11 455 1203.36363636364 960 5.83825389336867e-14 28 1.40408295462935 1.47034005371511 1 48.7468828720111 455 1975 28 2036 1930 960 789 1299 2948 157 660 466 M14506 GO_AMMONIUM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSPORT.html The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 46/97 Gene Ontology BP GO:0015696 0.00195514128114822 0.00641104466609068 1765 1053.90909090909 961 0.000177898271020902 183 1.11163478863632 1.0633516276115 1 8.32436938042672 1764 183 961 277 513 1319 915 674 1028 1341 2618 467 M14704 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE.html The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. 45/50 Gene Ontology BP GO:0006120 4.82298133759789e-06 6.75700114917743e-05 5 1341.63636363636 962 4.38453810079989e-07 3 0.582856503875532 -0.582856503875532 -1 8.29961883784539 3 1559 3778 962 604 213 128 913 1050 4311 1237 468 M16686 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of hydrogen ion (proton) across a membrane. 85/121 Gene Ontology BP GO:1902600 0.00135337158158692 0.00495227511886872 120 1274.27272727273 963 0.000123109531947796 73 0.801080442824009 -0.669676728032256 -1 6.30292557558086 116 73 3557 963 440 363 316 1257 1425 3976 1531 469 M11251 GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic hydroxy compound. 420/648 Gene Ontology BP GO:1901615 2.8586343236338e-10 1.40012900082822e-08 3755 1750.54545454545 965 2.59875847636839e-11 5 1.25880860355925 -1.24149911343906 -1 33.7906621778767 3753 610 68 5 965 2188 4085 4488 872 61 2161 470 M12466 GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. 45/50 Gene Ontology BP GO:0001953 0.00118623314065117 0.0044656495173543 1375 1579.63636363636 966 0.000107897567009766 199 1.41821286860327 1.64439636434086 1 11.3845653022083 1372 913 966 777 4260 2783 2607 199 2528 620 351 471 M13416 GO_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_URINE_VOLUME.html Any process that modulates the amount of urine excreted from the body over a unit of time. 18/30 Gene Ontology BP GO:0035809 0.0043249256087722 0.0113887260088382 580 1545.18181818182 966 0.000393950122463676 360 1.09353462366392 1.16955404303362 1 7.2556662066418 576 470 1201 3471 3476 832 360 401 4056 1188 966 472 M13418 GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 7/19 Gene Ontology BP GO:0001963 0.00999508334024989 0.020642309268612 970 1955 966 0.00100403257594214 331 0.830135989515293 -0.830135989515293 -1 4.77237559519463 966 556 4426 3046 1526 484 466 670 4490 4544 331 473 M14419 GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/49 Gene Ontology BP GO:0032369 0.00637812531568474 0.01453153638563 705 1138.72727272727 969 0.000581517440538067 444 1.17029206202187 1.31990656268411 1 7.34223567567391 703 969 1304 2568 2434 660 444 509 1074 1058 803 474 M13662 GO_NEGATIVE_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANOIKIS.html Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. 32/35 Gene Ontology BP GO:2000811 0.0209715189848482 0.0368645552839057 85 1072.81818181818 970 0.00192492176887449 84 1.30530609618536 1.29594486495498 1 6.38623571863901 84 970 1701 1409 2707 572 542 1071 532 1665 548 475 M13294 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP.html Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. 7/13 Gene Ontology BP GO:0045188 4.82661487827207e-05 0.000439942650865457 15 1484.45454545455 971 4.82671971442709e-06 15 1.50023360756088 1.81201130260341 1 17.2060964940961 930 1868 4418 2587 971 223 15 15 2668 2593 41 476 M15958 GO_TELENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. 288/430 Gene Ontology BP GO:0021537 4.94468292889077e-06 6.86794318451604e-05 700 1484.18181818182 972 4.49517640228343e-07 245 1.20726805626332 1.31148510266064 1 17.1731929486374 698 2488 245 3417 2028 696 1339 899 3058 486 972 477 M13477 GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of osteoblast proliferation. 40/49 Gene Ontology BP GO:0033688 0.00539943340183296 0.0133281504608641 1980 1492.54545454545 974 0.000492066443510369 218 1.49072614466179 1.60862995573689 1 9.54684930025357 1976 218 701 451 1582 3812 2577 2858 459 974 810 478 M12233 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 39/43 Gene Ontology BP GO:0010656 0.00562403247818751 0.0134540021460564 3580 1801.18181818182 975 0.000512587390868172 233 1.40513048549857 1.37321568551421 1 8.97846042214724 3579 936 707 233 1914 4432 2849 3340 975 535 313 479 M15159 GO_RESPONSE_TO_DEXAMETHASONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DEXAMETHASONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 32/45 Gene Ontology BP GO:0071548 7.36228819511779e-06 9.90078814216273e-05 955 1055.45454545455 975 6.6930116664465e-07 22 1.1912719520612 1.19491981700178 1 16.2985583336076 951 975 1177 1777 22 520 745 673 2468 1316 986 480 M14497 GO_LIPID_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 85/112 Gene Ontology BP GO:0046834 0.00577426225782821 0.0134540021460564 2505 1436.90909090909 976 0.000526315789473684 62 1.16084699145257 1.13277678187967 1 7.41569138660671 2501 62 938 126 3013 673 1497 2840 677 976 2503 481 M10410 GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. 110/127 Gene Ontology BP GO:2000058 0.0209357242162548 0.0368155422442304 130 1340.81818181818 978 0.00192160444753855 21 0.68198146791417 -0.657203723803606 -1 3.33286316516442 129 21 4129 641 1148 335 898 978 1113 4306 1051 482 M13835 GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. 72/76 Gene Ontology BP GO:0030433 2.42021315094057e-05 0.000260075099106847 585 1525.81818181818 979 2.20021797821833e-06 60 0.83691800650972 -0.86150419689592 -1 10.2470970139465 584 845 3940 644 60 979 1752 1176 2040 3866 898 483 M13089 GO_RENAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_TUBULE_DEVELOPMENT.html The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. 104/137 Gene Ontology BP GO:0061326 6.249996589814e-09 2.03365273653179e-07 170 1168.18181818182 980 5.68181509779059e-10 107 1.33775501501714 1.26688345813458 1 30.5953654036152 170 2057 107 1796 2074 356 651 1573 2789 297 980 484 M15367 GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. 22/33 Gene Ontology BP GO:0006658 0.00350595926302111 0.00983910039254356 1600 979.181818181818 980 0.00031923262904178 22 1.45883424432675 -1.55199036871557 -1 9.9998285354435 1599 341 980 22 1083 1337 2773 1255 338 437 606 485 M16578 GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. 23/33 Gene Ontology BP GO:0045940 0.0127786995746804 0.0249513076545515 3060 1931.81818181818 981 0.00116850308233778 179 1.49017294134016 1.18749666781135 1 8.15586292867522 3058 335 852 403 981 4261 3272 3468 179 659 3782 486 M10039 GO_CARDIAC_CHAMBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_DEVELOPMENT.html The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. 193/257 Gene Ontology BP GO:0003205 2.48305561609545e-05 0.000264385761594786 2910 1230.63636363636 983 2.25734876530421e-06 1 1.27152200338524 1.3262233906729 1 15.5428230364178 306 2524 356 2906 1522 232 983 688 2907 1112 1 487 M11931 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. 74/109 Gene Ontology BP GO:0034121 0.00246750639028025 0.00752872605506491 65 957.727272727273 983 0.000224570753061319 64 1.23934856891284 1.15239036108284 1 8.98623636004746 64 1508 983 1341 2879 230 196 301 1025 1111 897 488 M13318 GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. 16/31 Gene Ontology BP GO:1901623 0.000436832656743255 0.00221655654506692 2375 1458.72727272727 984 3.9719947135032e-05 439 1.66307075073039 -1.60108992637288 -1 15.0816784907057 2375 458 439 984 535 3128 2366 1194 934 643 2990 489 M12120 GO_RESPONSE_TO_XENOBIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_XENOBIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. 74/205 Gene Ontology BP GO:0009410 2.61024634101961e-10 1.30596518545852e-08 3440 1598.72727272727 985 2.37295121939028e-11 66 1.57502727175969 -1.54090547641073 -1 42.4445360214531 3439 93 66 255 299 2813 3816 3046 985 98 2676 490 M13797 GO_RESPONSE_TO_AUDITORY_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AUDITORY_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. 30/48 Gene Ontology BP GO:0010996 0.000470421528192026 0.00232364264403131 2770 1338.72727272727 985 4.27747406903481e-05 100 1.41730016830195 -1.51583110482812 -1 12.7520238624557 2768 985 798 129 602 2296 3854 100 1487 1160 547 491 M11543 GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 23/32 Gene Ontology BP GO:0046131 0.000310414367960488 0.00174439378516926 215 1627.72727272727 986 2.82234704806298e-05 74 0.890057737361806 -0.890057737361806 -1 8.38318003076338 213 3147 3401 2127 3885 89 150 74 986 3478 355 492 M14320 GO_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 29/38 Gene Ontology BP GO:0070741 0.0302196039090574 0.0494589577871417 610 1335.45454545455 986 0.0027857153012783 480 1.25681400448284 1.21660384640728 1 5.60014179236368 607 986 1631 832 4582 742 480 1521 826 1072 1411 493 M15526 GO_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_DEVELOPMENT.html The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 151/190 Gene Ontology BP GO:0001890 0.000468695876129738 0.00232364264403131 2330 1453.09090909091 988 4.26177962335868e-05 90 1.25291717668094 1.30352800154573 1 11.2717667855167 2326 727 445 90 988 2125 2280 2826 596 463 3118 494 M12997 GO_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_MORPHOGENESIS.html The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 271/374 Gene Ontology BP GO:0003007 4.74202126350394e-07 9.19359372461827e-06 640 1452.27272727273 989 4.31092935057269e-08 27 1.25276308210206 1.25004557150557 1 21.561389769515 639 3286 183 3127 1949 989 1490 453 3363 469 27 495 M15858 GO_TRYPTOPHAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRYPTOPHAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. 7/13 Gene Ontology BP GO:0006568 0.000387782559636242 0.0020182911073685 990 1947.09090909091 990 3.87850245151201e-05 93 2.35280436774652 -2.35280436774652 -1 21.668355647835 990 4601 4577 3981 322 472 93 96 3275 2598 413 496 M11666 GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS.html The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 32/36 Gene Ontology BP GO:0003203 0.000403532900634301 0.00208716299106072 950 1149.81818181818 992 3.66915397531242e-05 52 1.64370185640731 1.54934820693293 1 15.0527071922129 946 2213 434 1613 1485 812 476 2090 1535 992 52 497 M15018 GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 54/83 Gene Ontology BP GO:0050810 0.000700077699541229 0.00308764126631786 530 1221.27272727273 993 6.36636886873037e-05 169 1.26601298330006 1.06365533369811 1 10.8553162278521 530 169 472 1336 2473 300 226 3588 2318 1029 993 498 M10138 GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. 27/30 Gene Ontology BP GO:0019682 0.000247581778211851 0.00147692053079454 1435 1191.63636363636 994 2.25099677050471e-05 65 1.22659420255356 -1.33263077962531 -1 11.8600939855791 1431 994 1908 65 209 975 2242 1853 400 676 2355 499 M12796 GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. 92/121 Gene Ontology BP GO:0009063 0.0044902791692209 0.0116591902758844 995 1420 994 0.00040904275131248 496 1.29139423224499 -1.27790575049512 -1 8.52540024965895 994 2582 1912 977 709 496 2167 514 1901 2668 700 500 M16177 GO_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 20/24 Gene Ontology BP GO:0070227 0.000296422988255704 0.00169441789232652 1630 1229.72727272727 995 2.69511759226699e-05 213 0.696753003163903 -0.736902745757828 -1 6.59025886222479 1626 339 2953 376 226 1300 1952 995 217 3330 213 501 M13894 GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. 65/71 Gene Ontology BP GO:0034446 0.000215005931353116 0.00133212063726504 80 934.090909090909 996 1.95479042501365e-05 8 1.21531121681135 1.2629524494535 1 11.9371034936063 76 1526 996 2341 2106 8 378 60 1628 1117 39 502 M13177 GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION.html A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. 16/20 Gene Ontology BP GO:0014829 0.000381121930402371 0.00200025261221394 625 1792.09090909091 997 3.46534519028745e-05 90 1.826858993879 1.85017170312456 1 16.8465852715124 624 3546 997 3250 3517 2005 896 90 3385 958 445 503 M16579 GO_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that modulates the frequency, rate or extent of lymphocyte migration. 32/59 Gene Ontology BP GO:2000401 0.0007033564111028 0.00309122433779457 2785 1734.27272727273 999 6.39619436449629e-05 429 1.65957555412393 -1.45647139419921 -1 14.2303404215261 2783 964 474 497 950 2452 2347 3366 999 429 3816 504 M13057 GO_OVULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION.html The release of a mature ovum/oocyte from an ovary. 24/28 Gene Ontology BP GO:0030728 0.00020531409973365 0.0012873468850097 135 1573.18181818182 1001 1.86666602810741e-05 56 1.39110972642035 1.34034021654732 1 13.736003557105 133 3137 1001 3270 3694 71 69 56 3900 1779 195 505 M13233 GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 60/75 Gene Ontology BP GO:0009142 0.0134785881309473 0.0260123892879708 70 1425.54545454545 1001 0.00123289834375766 69 0.731463956153146 -0.70038237707864 -1 3.95271279262223 69 1540 3887 1582 1001 292 284 1000 819 3773 1434 506 M11987 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. 28/58 Gene Ontology BP GO:0032715 0.00551126169005365 0.0134540021460564 600 978.090909090909 1003 0.000502283333845324 542 1.33143006196022 1.29586819344386 1 8.50697240670948 596 1003 1353 635 753 1053 1162 1694 542 734 1234 507 M10912 GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. 28/42 Gene Ontology BP GO:0033006 0.00468888131756082 0.012003292098705 445 1423.54545454545 1004 0.000427173154238404 143 0.859740327570249 0.896145575126055 1 5.63505507437749 443 1004 2957 1888 2741 297 143 500 1680 3386 620 508 M12708 GO_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of mast cell degranulation. 28/42 Gene Ontology BP GO:0043304 0.00331638419021636 0.00944377945965528 445 1410.54545454545 1005 0.000301944912810897 144 0.859740327570249 0.896145575126055 1 5.94120764717011 444 1005 2958 1889 2742 298 144 344 1681 3390 621 509 M10800 GO_RESPONSE_TO_DIETARY_EXCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DIETARY_EXCESS.html The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. 18/30 Gene Ontology BP GO:0002021 0.0167879182214311 0.0309118256764222 1180 1002.63636363636 1006 0.00153794638151826 330 1.40601954862242 1.48880906297614 1 7.24746937972915 1179 436 1223 399 2135 561 330 1615 1006 1181 964 510 M12424 GO_NEGATIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 457/670 Gene Ontology BP GO:0051051 0.000362620287938737 0.00194610403665391 760 1162.63636363636 1006 3.29709155904822e-05 122 1.15546108056788 1.22891623492806 1 10.6983800585165 756 1341 427 1006 2881 122 977 2059 1826 380 1014 511 M11371 GO_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). 479/666 Gene Ontology BP GO:0001501 6.11098433942363e-14 9.17239036494779e-12 620 1234.54545454545 1007 5.55544030856706e-15 22 1.27953932476339 1.37457385077249 1 48.2749179614041 619 2462 22 1500 2187 1007 1426 460 3435 281 181 512 M14177 GO_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 102/179 Gene Ontology BP GO:0070542 2.83657913337356e-06 4.27139246200232e-05 1015 1004.36363636364 1011 2.57871162794113e-07 44 1.28419351406202 1.30571503859334 1 19.1737154504841 1045 44 230 355 1262 837 1013 1011 2759 236 2256 513 M12865 GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 228/317 Gene Ontology BP GO:0090092 1.23050355972319e-06 2.037460484167e-05 560 1255 1012 1.11864022542612e-07 53 1.33914899567901 1.26372678858824 1 21.4665783421737 559 2958 212 2334 2867 53 1012 1073 2127 417 193 514 M12137 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 27/30 Gene Ontology BP GO:0051985 0.017053634432693 0.0313227439754325 635 1600.54545454545 1013 0.00156248008316698 367 0.815045551326355 -0.815045551326355 -1 4.18077111384626 632 2239 3750 1639 1822 1013 970 803 715 3656 367 515 M10907 GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 58/68 Gene Ontology BP GO:0048146 0.0031654145702272 0.00911427846241778 4045 1917.81818181818 1014 0.000288179840248448 141 1.20872569313326 -0.936196361877328 -1 8.42092677424358 4041 141 801 1014 605 3330 3606 1744 744 636 4434 516 M11983 GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. 32/44 Gene Ontology BP GO:0006778 2.23389084534391e-05 0.000243970942265447 1020 1579.90909090909 1016 2.03083048064012e-06 57 0.761023189619286 -0.754450266678713 -1 9.38911589783067 1016 287 3395 188 57 518 869 1947 3085 3838 2179 517 M12716 GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 25/81 Gene Ontology BP GO:0070098 0.000134865766742039 0.000949365223374749 165 1595 1016 1.22612759160622e-05 162 1.55921413011397 1.65078631067213 1 16.1022505317851 162 2761 367 2489 4477 395 214 1016 4061 1098 505 518 M11169 GO_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORT.html A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 172/301 Gene Ontology BP GO:0098656 1.60455580746043e-05 0.000186649954302835 4155 2033 1017 1.45869773664018e-06 12 1.25530422591613 -1.22104368309157 -1 15.9934109817336 4155 712 271 12 987 3071 4476 4547 1017 488 2627 519 M14602 GO_DETECTION_OF_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_STIMULUS.html The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. 235/1291 Gene Ontology BP GO:0051606 1.4605501896813e-05 0.000175153093623379 530 1297.81818181818 1018 1.32778171469657e-06 93 1.2704348981068 1.34677529175168 1 16.3062400793353 526 2504 268 2048 2557 93 1373 1018 2939 704 246 520 M14284 GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 25/38 Gene Ontology BP GO:0060117 0.00236673048829588 0.00732395608126999 1260 1247.45454545455 1019 0.000215389129681751 266 1.44846270001123 1.42275672410229 1 10.5635813639931 1256 2255 2284 2211 550 385 266 742 1019 1882 872 521 M11721 GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 75/133 Gene Ontology BP GO:0045913 0.0143985007092541 0.0273898366724963 435 1458.81818181818 1021 0.00131760074708649 433 1.11562743143857 1.16063447486583 1 5.94879530079324 433 836 1757 2151 2813 1021 690 760 2849 1888 849 522 M10195 GO_NUCLEOSOME_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_DISASSEMBLY.html The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. 22/41 Gene Ontology BP GO:0006337 0.00250332069213212 0.00763299553112106 575 1594.18181818182 1022 0.000227833972654755 182 0.921208245385389 -0.921208245385389 -1 6.65792170523815 573 2280 3257 3020 2404 534 1022 302 546 3416 182 523 M10379 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 21/25 Gene Ontology BP GO:1900153 5.49328905596945e-05 0.00048226932032879 100 1313.45454545455 1022 4.99402384129278e-06 40 0.879548432198911 0.915307763207861 1 9.96311586934212 256 1086 3180 2330 96 40 227 1022 2380 3735 96 524 M16669 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN.html The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. 14/23 Gene Ontology BP GO:0006123 0.00107857021366734 0.00418564404019528 105 1407.63636363636 1022 9.80999414403362e-05 103 0.607877467139183 -0.607877467139183 -1 4.93203124733391 103 1779 3509 1022 409 358 418 1125 560 4647 1554 525 M10543 GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-DNA complex into its constituent components. 22/41 Gene Ontology BP GO:0032986 0.00237441031930101 0.00733593836475714 575 1594.45454545455 1023 0.000216088804142626 183 0.921208245385389 -0.921208245385389 -1 6.71221806639676 574 2281 3258 3021 2405 535 1023 294 547 3418 183 526 M13507 GO_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASODILATION.html An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. 27/34 Gene Ontology BP GO:0042311 0.000795748044905079 0.00338447500269043 1010 1508.81818181818 1023 7.2366910519771e-05 480 1.59441981541235 1.42957618958671 1 13.4566667565753 1009 1023 480 2034 4631 2209 857 878 1687 678 1111 527 M12949 GO_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 137/175 Gene Ontology BP GO:0051591 5.15110083184668e-05 0.000463599074866202 1025 1704.09090909091 1024 4.68292858560271e-06 316 1.38231908344799 1.22923684565705 1 15.7454015962741 1024 2980 316 4123 781 366 689 3485 2701 457 1823 528 M11761 GO_AXON_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_REGENERATION.html The regrowth of axons following their loss or damage. 26/34 Gene Ontology BP GO:0031103 0.000184411236862255 0.00117866138065944 920 1076.54545454545 1025 1.67660633302746e-05 53 1.7733857027735 2.04712061661974 1 17.7458346181516 917 2758 1305 1622 2038 1025 281 53 219 1525 99 529 M14010 GO_RESPONSE_TO_CARBOHYDRATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CARBOHYDRATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 192/256 Gene Ontology BP GO:0009743 0.00652450874526221 0.0147658264551095 230 1056.45454545455 1027 0.000594903555479352 187 1.08944228541702 1.11562660587464 1 6.80838682266437 230 1402 2218 2385 1027 187 333 518 1743 1363 215 530 M14826 GO_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_SIGNALING.html A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. 20/20 Gene Ontology BP GO:0031929 0.00434809393695031 0.0114174272509197 595 1375.63636363636 1027 0.000396064671911489 509 0.97799480014253 1.02596120169347 1 6.48427108256083 592 1079 3267 834 691 509 592 1080 1027 3328 2133 531 M11546 GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of B cell proliferation. 35/57 Gene Ontology BP GO:0030890 0.00886902250111442 0.0187835965852005 1230 1367.27272727273 1032 0.000809543632011024 218 1.16163539618025 1.12387024929195 1 6.84514629440469 1230 953 821 1032 3261 593 218 631 3845 1211 1245 532 M14199 GO_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSSIFICATION.html The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. 327/459 Gene Ontology BP GO:0001503 7.09155797182934e-13 7.33267094287154e-11 305 1288.36363636364 1032 6.44687088348331e-14 30 1.35466604867165 1.42729392564446 1 46.9286991001058 302 1938 30 2792 2935 1069 1032 527 3035 207 305 533 M14572 GO_PERICARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. 25/30 Gene Ontology BP GO:0060039 0.000610370819097707 0.00281291420843119 1365 909.636363636364 1032 5.55036569967794e-05 130 1.37686812467662 1.26071209416272 1 11.9972792074591 1363 1032 1437 674 445 1365 949 130 209 1099 1303 534 M13091 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. 102/138 Gene Ontology BP GO:0002474 0.00840516425774378 0.0180393124037278 280 1543 1033 0.000767040840898504 267 0.828807860095067 -0.619616261238647 -1 4.93060032488898 278 784 3553 1794 865 267 506 1339 2455 4099 1033 535 M14175 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. 47/51 Gene Ontology BP GO:0014911 0.00110477874825893 0.00424136593700397 250 1428.72727272727 1033 0.000100484902521869 192 1.3764902260854 1.53789884465397 1 11.1546455389263 247 2657 715 2519 638 913 1033 192 3889 1416 1497 536 M16945 GO_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. 42/58 Gene Ontology BP GO:0019933 0.00558077000604277 0.0134540021460564 525 1177.18181818182 1033 0.000508634300262633 214 1.27413669311313 1.29375884483737 1 8.14044619860156 522 214 1033 375 3492 1279 1420 471 1636 839 1668 537 M16092 GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 35/47 Gene Ontology BP GO:0009069 0.00442828462734191 0.0115497804770302 300 1538.90909090909 1034 0.000403383938992352 270 1.34291736724568 -1.43661726381692 -1 8.88476613636671 300 2693 2812 1034 4033 781 1360 407 270 2293 945 538 M11897 GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of astrocyte differentiation. 34/50 Gene Ontology BP GO:0048710 0.00508267678738081 0.0127629223376594 175 1096.54545454545 1035 0.00046313249597778 83 1.2698849071624 1.19559867414749 1 8.21267616709476 171 2702 1457 2946 1035 83 242 442 1556 1136 292 539 M16576 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 203/279 Gene Ontology BP GO:0007178 0.00379070629189858 0.010384592062893 445 1236.27272727273 1036 0.00034520487831336 194 1.23608922689187 1.29598461177156 1 8.37232150410462 445 2521 643 2093 1669 275 779 1036 2835 1109 194 540 M11382 GO_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins. 41/47 Gene Ontology BP GO:0097435 0.000468392702943813 0.00232364264403131 15 1657.54545454545 1037 4.25902232899386e-05 14 1.32560175742753 1.40311304830994 1 11.9262862341135 14 3412 759 3193 1830 659 718 1037 4531 1625 455 541 M14021 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 53/78 Gene Ontology BP GO:0002066 0.0105972492619096 0.0216078005327193 1580 1061.81818181818 1038 0.000968058400127496 153 1.22665343952321 1.20802962583505 1 6.97375334800787 1578 153 1487 356 922 1038 1046 1954 468 970 1708 542 M10255 GO_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 56/64 Gene Ontology BP GO:0010883 0.00544420489651807 0.0134173121734632 1560 1097 1040 0.000496156745166028 114 1.32798577543311 1.33522938948708 1 8.4903227392974 196 1558 1040 1556 2933 114 244 463 2324 1397 242 543 M16105 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. 147/216 Gene Ontology BP GO:1903035 1.51427494762532e-12 1.40918426626012e-10 1045 1086 1041 1.37661358875123e-13 33 1.56058906789526 1.51474532443528 1 52.5502279999298 1041 739 33 961 1947 1558 1659 668 2125 54 1161 544 M12623 GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 57/98 Gene Ontology BP GO:0071384 0.000122679032832623 0.000878193138107993 2260 1346.45454545455 1043 1.11532613037981e-05 163 1.32205951266355 1.32715734550713 1 13.8044689395411 2258 163 362 1748 233 728 1043 2175 3061 398 2642 545 M13112 GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). 45/111 Gene Ontology BP GO:0007200 2.5752493780537e-06 3.95466513402108e-05 2200 1095.45454545455 1047 2.34113853869354e-07 206 1.65444289151183 1.54108072557592 1 24.8940800669867 2197 206 227 735 1047 1033 1868 1151 1224 379 1983 546 M10557 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. 13/24 Gene Ontology BP GO:0032692 0.000150766359075784 0.0010301260921874 500 1273.45454545455 1050 1.37069720100334e-05 161 1.20061650759793 1.26715601512118 1 12.2509582180716 498 3209 1995 1050 161 1405 760 2056 443 1018 1413 547 M15054 GO_PARAXIAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARAXIAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. 17/23 Gene Ontology BP GO:0048339 0.000206339648857103 0.00129045482007003 2030 1253.45454545455 1050 1.87599094680864e-05 7 1.50410971466737 -1.52198121788356 -1 14.8472614073556 2027 1747 1676 908 3686 815 1219 412 241 1050 7 548 M14015 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. 17/42 Gene Ontology BP GO:0042534 0.0014309529661084 0.00514943863209775 65 1064 1052 0.000130171323072483 62 1.18236143011296 1.32051995565674 1 9.23939121096332 62 2320 1362 2375 457 215 163 1052 1838 1481 379 549 M14438 GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of B cell proliferation. 20/36 Gene Ontology BP GO:0030889 0.000271092995029465 0.00158069637327331 710 1162.72727272727 1052 2.46478550891551e-05 69 1.32309127849976 1.38129976530996 1 12.6605688531594 706 1052 1876 759 1411 1579 419 69 403 1391 3125 550 M15512 GO_TELENCEPHALON_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_REGIONALIZATION.html The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. 5/18 Gene Ontology BP GO:0021978 0.00135386263657658 0.00495227511886872 1620 1465.81818181818 1052 0.000135468816933195 10 0.974030439836734 1.28264912612818 1 7.66600351552372 1616 1250 4561 858 599 1052 1792 222 10 3161 1003 551 M10465 GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 55/64 Gene Ontology BP GO:0071364 0.0272243776505867 0.0457310574758772 310 1177.81818181818 1053 0.00250611147764877 151 1.02703960724825 1.0815184885321 1 4.69386396557724 308 151 1053 915 1769 565 1288 1552 3593 1325 437 552 M14085 GO_RESPONSE_TO_AMINO_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINO_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 146/177 Gene Ontology BP GO:0043200 0.000462925551559836 0.00231363328830066 435 1016.27272727273 1053 4.20929990351086e-05 337 1.28328577245896 1.14255076042237 1 11.5534595382191 434 737 444 835 1557 1238 1053 1985 1274 337 1285 553 M16275 GO_REGULATION_OF_CELL_PROJECTION_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_SIZE.html A process that modulates the size of a cell projection. 17/27 Gene Ontology BP GO:0032536 0.00245838302983598 0.00750581117967638 1365 1106.72727272727 1053 0.000223739495228661 300 1.33729460132955 -1.44347033412627 -1 9.70331645581684 1365 1758 1544 1010 849 1439 785 300 1536 1053 535 554 M14244 GO_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 41/61 Gene Ontology BP GO:0009268 0.00143575540334777 0.00515492627483987 2760 1415.09090909091 1054 0.000130608477947532 96 1.21704959779363 -1.13112736476602 -1 9.50884489599235 2757 203 1013 96 458 3340 2612 1160 861 2012 1054 555 M14471 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 49/81 Gene Ontology BP GO:0090280 0.0028704600558608 0.00844797636933604 4035 2328.36363636364 1054 0.000261292014302772 143 1.25141905819028 -1.32098207940893 -1 8.85980033162308 4031 884 702 143 578 4259 4446 4370 1054 791 4354 556 M13163 GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY.html Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. 9/17 Gene Ontology BP GO:0006957 0.000213534302667749 0.00132830897100673 105 1264.36363636364 1056 2.13554824047369e-05 61 2.33233495556778 2.33233495556778 1 22.9285255703593 105 2412 4413 1735 1056 577 301 61 1674 1467 107 557 M12499 GO_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPROUTING_ANGIOGENESIS.html The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. 69/83 Gene Ontology BP GO:0002040 0.0015407842102145 0.00544777274325841 415 1914.90909090909 1057 0.000140169487966375 149 1.34015521857999 1.34056815868437 1 10.3618011794113 414 3347 540 3838 4626 661 968 1057 4146 1318 149 558 M11099 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. 84/89 Gene Ontology BP GO:0033108 0.000199688629841923 0.00126415128524418 15 1442.45454545455 1058 1.81551597631828e-05 12 0.636686882041787 -0.615268120690149 -1 6.2981380412913 12 1480 4031 988 567 317 240 1058 1405 4347 1422 559 M11796 GO_MEMBRANE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a membrane. 32/40 Gene Ontology BP GO:0071709 0.0167275114421249 0.0308249943525573 810 1525.63636363636 1058 0.00153236983633082 326 1.12786717089197 -1.12478913530541 -1 5.81630635392993 807 971 1942 1058 4642 468 1037 1217 1458 2856 326 560 M15599 GO_KIDNEY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MORPHOGENESIS.html Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 84/117 Gene Ontology BP GO:0060993 9.16654689284808e-07 1.59149039897097e-05 880 1360.81818181818 1058 8.33322792017721e-08 204 1.38197935616098 1.27890633860666 1 22.6604039717232 879 1484 204 726 2373 894 1058 3049 1555 456 2291 561 M14070 GO_REGULATION_OF_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GASTRULATION.html Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. 49/69 Gene Ontology BP GO:0010470 0.00187042083230432 0.0062477158167351 95 1510.27272727273 1060 0.000170182994832779 93 1.37146918200662 1.40249978103143 1 10.3251582910031 93 2654 636 3852 500 1060 744 1121 3818 1871 264 562 M14909 GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. 44/58 Gene Ontology BP GO:0031952 0.0107525583670449 0.0218288194074433 395 1353.54545454545 1060 0.000982315837813667 235 1.1319886495141 1.15667932971187 1 6.41763839111167 392 2660 1917 2387 926 235 324 1051 1733 2204 1060 563 M13107 GO_REGULATION_OF_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ORGANIZATION.html Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 124/183 Gene Ontology BP GO:0050807 2.95212956854965e-07 6.07799065595642e-06 790 1352.90909090909 1061 2.68375451335383e-08 174 1.46940323354866 1.32868914098805 1 26.1947479885726 786 2553 174 2004 2483 581 641 2406 1727 466 1061 564 M14245 GO_SMALL_MOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. 313/427 Gene Ontology BP GO:0044282 0.00270902991386596 0.0080957714766977 2505 1201.54545454545 1063 0.000246579228520518 18 1.16857764161276 -1.12584803545181 -1 8.34648455128842 1757 641 1063 18 570 712 2505 2502 1093 586 1770 565 M12903 GO_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 403/509 Gene Ontology BP GO:0070482 8.99128958429795e-08 2.22534417211374e-06 840 1410.09090909091 1064 8.17389995615224e-09 112 1.22890541544568 1.237740264488 1 23.73910381767 839 2946 142 2785 2751 112 1627 1064 2642 227 376 566 M10135 GO_METANEPHRIC_NEPHRON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. 16/29 Gene Ontology BP GO:0072273 0.0276624401140435 0.0463164209610092 780 1285 1066 0.00254695562494453 587 1.4675355423347 1.39324092950706 1 6.68391426941329 778 1765 1446 1860 2065 993 701 985 587 1889 1066 567 M12060 GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. 78/125 Gene Ontology BP GO:1901616 0.000735693357923177 0.00319994919147309 3255 1643.18181818182 1066 6.69035903172423e-05 87 1.30236240034667 1.23374916553037 1 11.0982079104543 3252 87 476 932 1066 2964 3258 730 1122 343 3845 568 M12885 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. 55/92 Gene Ontology BP GO:1903727 0.00810143316425331 0.0174923287764597 915 1431.63636363636 1067 0.00073922010563264 146 1.10001070177818 1.20925141883252 1 6.59777419299474 913 146 761 1665 2989 588 234 2764 2811 1067 1810 569 M13871 GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that activates or increases the frequency, rate, or extent of tissue remodeling. 22/31 Gene Ontology BP GO:0034105 0.0028287152136856 0.00835856302424057 1015 1780.27272727273 1067 0.000257487170794701 452 1.70385764460631 2.01343423913085 1 12.0937509512589 1015 3492 616 2764 4300 1163 452 528 3589 597 1067 570 M10321 GO_REGULATION_OF_COLLATERAL_SPROUTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COLLATERAL_SPROUTING.html Any process that modulates the frequency, rate or extent of collateral sprouting. 25/35 Gene Ontology BP GO:0048670 0.0017258396283301 0.00590031725982364 650 1241.27272727273 1069 0.000157017726448641 250 1.60991333620061 1.51585874824606 1 12.2589051115898 648 1021 881 1275 489 1800 1069 3094 250 1096 2031 571 M13798 GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION.html The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. 111/170 Gene Ontology BP GO:0099531 0.00577426225782821 0.0134540021460564 4220 1726.09090909091 1069 0.000526315789473684 26 1.25786836751141 -1.55724421042594 -1 8.0363718909626 4219 26 935 78 1127 4473 3889 882 1069 877 1412 572 M11084 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. 20/25 Gene Ontology BP GO:0034143 0.0194912678751826 0.034854625372926 370 1289.45454545455 1070 0.00178782970668836 370 1.36650725508233 1.5650694857668 1 6.79992049361069 370 1070 2150 1608 2794 658 800 853 391 2351 1139 573 M13193 GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. 26/30 Gene Ontology BP GO:0036119 0.00468112507952174 0.0119982956368395 770 1163.54545454545 1071 0.000426465025057411 694 1.44226151588488 1.49681966375622 1 9.46122990059174 767 1671 1626 1499 718 870 1831 876 694 1176 1071 574 M11953 GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. 19/21 Gene Ontology BP GO:0051560 0.00261938126529902 0.00788402312938746 255 1162.54545454545 1072 0.000238409562000951 45 0.851441948963681 -0.781339995030198 -1 6.11197823650958 252 1072 2803 1781 1343 45 186 671 1260 3224 151 575 M12936 GO_RESPONSE_TO_ISCHEMIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISCHEMIA.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. 39/46 Gene Ontology BP GO:0002931 0.00211837251278161 0.00676977149860771 2440 1257.81818181818 1072 0.000192765003675972 234 1.18309839296842 1.13351909744441 1 8.76455942115467 2436 234 1759 385 527 1072 873 1875 497 1474 2704 576 M14729 GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. 217/287 Gene Ontology BP GO:0001763 4.61244540859496e-10 2.12298550352829e-08 595 1265.45454545455 1072 4.1931321905109e-11 73 1.33385863214014 1.33186593407004 1 34.9814703115067 594 2511 73 1125 2446 225 1072 2581 2673 280 340 577 M12292 GO_KIDNEY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. 25/30 Gene Ontology BP GO:0061440 9.61783811177723e-06 0.000123623758933976 240 1837.36363636364 1073 8.74352741706034e-07 3 1.47973203703847 1.45382569936757 1 19.7598858144145 238 4498 1073 4584 3611 389 121 3 4248 1435 11 578 M16607 GO_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION.html The addition of tubulin heterodimers to one or both ends of a microtubule. 28/34 Gene Ontology BP GO:0046785 0.000128894863361789 0.00091911126528229 1075 1568.36363636364 1073 1.17184014315951e-05 3 1.30694261651282 -1.34000312612606 -1 13.5581262312579 1073 4448 3262 906 3538 430 1101 303 13 2175 3 579 M14598 GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. 25/30 Gene Ontology BP GO:0061437 2.80173210043148e-06 4.24630185254455e-05 240 1838.18181818182 1074 2.54703242589504e-07 1 1.47973203703847 1.45382569936757 1 22.1077810588483 239 4499 1074 4585 3612 390 122 1 4249 1437 12 580 M11433 GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. 71/79 Gene Ontology BP GO:0032922 0.00552929050187841 0.0134540021460564 160 1389.36363636364 1076 0.000503930585438421 159 0.958277047991067 0.998778539274341 1 6.11977887966834 160 1518 3535 1864 2868 166 159 823 1076 2761 353 581 M16283 GO_MYELOID_DENDRITIC_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_ACTIVATION.html The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 23/33 Gene Ontology BP GO:0001773 0.000589009054262644 0.00273792120827581 2455 1293.63636363636 1076 5.35606190552828e-05 125 1.18851002555887 -1.28397823967764 -1 10.4022574221524 2453 1044 1743 512 1205 1343 3288 125 526 915 1076 582 M12663 GO_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a lymphocyte. 106/369 Gene Ontology BP GO:0002449 0.00735809215022975 0.0162415572936523 465 1579 1077 0.000671165253245651 301 1.14236138255256 1.09800167800823 1 6.97804128380126 463 2571 744 2746 3921 301 447 1077 3130 1240 729 583 M15213 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that activates or increases the rate or extent of osteoblast proliferation. 18/22 Gene Ontology BP GO:0033690 0.00709527262325282 0.0157887630396917 1150 971.636363636364 1077 0.000647114510377942 134 1.62639672619364 1.71531691922691 1 10.0075394125806 1149 1077 736 421 1745 1091 804 2071 134 1191 269 584 M15978 GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. 20/24 Gene Ontology BP GO:0010640 7.26400175110798e-05 0.000588256948185597 2575 1271.45454545455 1077 6.60385600580349e-06 24 1.72795326434596 -1.31320235646612 -1 19.0740285057125 2574 401 1687 1077 827 2552 2540 24 45 1848 411 585 M11588 GO_CREATINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CREATINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. 8/10 Gene Ontology BP GO:0006600 0.00849435312699643 0.0181638866619536 2360 1448.36363636364 1078 0.000852699820270457 189 0.862520196215197 0.895406260308096 1 5.12277592000489 2357 1247 4313 833 1078 1196 531 611 189 2750 827 586 M16142 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. 65/115 Gene Ontology BP GO:0002690 9.76061057508153e-05 0.000732518080739586 1000 1728.81818181818 1079 8.87367604113483e-06 352 1.45027329903807 1.47746502942072 1 15.5348473505056 1000 3027 352 2975 4043 499 992 2049 2407 594 1079 587 M11570 GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. 20/32 Gene Ontology BP GO:0002714 0.00664870070295202 0.0149527513105124 975 1240.63636363636 1080 0.000606261764815881 526 1.17722017568627 1.18408432422214 1 7.33581800569114 974 1080 2220 1351 2953 1317 659 526 594 1387 586 588 M11257 GO_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOOD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. 13/27 Gene Ontology BP GO:0032094 0.00577426225782821 0.0134540021460564 1945 1433.27272727273 1081 0.000526315789473684 165 0.941303992592421 -1.09355266254238 -1 6.01119616302141 1944 494 2383 165 3262 1081 2147 784 456 2095 955 589 M14225 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. 20/32 Gene Ontology BP GO:0002891 0.00958956845613516 0.0200270475881494 975 1250.18181818182 1081 0.000875602295475902 587 1.17722017568627 1.18408432422214 1 6.82508087983963 975 1081 2221 1352 2954 1318 660 619 595 1390 587 590 M10363 GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. 220/300 Gene Ontology BP GO:0045665 0.00242245085008145 0.00742045016815601 1020 1587.09090909091 1082 0.000220465669444352 232 1.28963007772453 1.38869751654845 1 9.3789880148209 1020 2513 602 2415 3431 702 1082 2785 2054 622 232 591 M11188 GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 15/17 Gene Ontology BP GO:0009129 0.0056957115298081 0.0134540021460564 500 1694.63636363636 1082 0.0005191373788824 164 0.895276568863536 -0.895276568863536 -1 5.71674224230068 497 3558 3627 3068 1077 184 164 1230 280 3874 1082 592 M12187 GO_DIGESTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 176/259 Gene Ontology BP GO:0055123 1.63350559779973e-08 4.90367841713686e-07 700 1207.54545454545 1083 1.48500509993504e-09 115 1.34981946176703 1.32250336080496 1 29.1073367538281 696 1995 115 891 2632 1083 1879 1164 2378 211 239 593 M12833 GO_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TASTE.html The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. 28/88 Gene Ontology BP GO:0050909 0.00344463924765313 0.0097197734501698 1680 1246.18181818182 1083 0.000313640411549322 460 1.53842069803708 1.51486688584313 1 10.5738220647776 1679 997 637 1449 2654 1373 1784 1083 589 1003 460 594 M13728 GO_FEMALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_SEX_DIFFERENTIATION.html The establishment of the sex of a female organism by physical differentiation. 120/166 Gene Ontology BP GO:0046660 3.01334508106674e-05 0.000305470471943432 1085 1280.18181818182 1083 2.73944214155945e-06 208 1.42842516758245 1.28268393328127 1 17.1557298645978 1083 2048 295 2078 779 768 519 2329 2009 208 1966 595 M14906 GO_URATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. 9/18 Gene Ontology BP GO:0046415 0.0125331791122637 0.0245648198859995 510 1531.45454545455 1084 0.00126044316062687 498 1.03609972417673 1.03609972417673 1 5.69144283838562 507 2411 4524 1596 1084 694 623 743 498 2884 1282 596 M15880 GO_LIPID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_OXIDATION.html The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. 79/91 Gene Ontology BP GO:0034440 0.00547555128295806 0.0134540021460564 1155 1302.27272727273 1084 0.000499020635186876 82 0.970277170234299 -1.00009276362515 -1 6.19654796117202 1152 82 2928 1236 751 333 1401 941 1084 3345 1072 597 M11342 GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. 109/351 Gene Ontology BP GO:0002460 0.00307500770121098 0.00891464849453875 350 1499 1085 0.000279937651222482 348 1.19281011315212 1.1588661201785 1 8.34912999941646 348 2568 622 2753 2757 654 648 1085 3092 825 1137 598 M14188 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 130/153 Gene Ontology BP GO:0007179 0.00196231504819016 0.00642551155470007 410 1141.63636363636 1085 0.000178551595114096 375 1.23270214930242 1.32172284439706 1 9.22800620538318 375 2041 1085 1626 514 406 501 1286 2938 1379 407 599 M14816 GO_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_DISASSEMBLY.html A process that results in the breakdown of the extracellular matrix. 70/149 Gene Ontology BP GO:0022617 9.56169756413952e-08 2.31721764405944e-06 3370 2130.63636363636 1085 8.69245270882959e-09 144 1.53612245853959 1.68245143160367 1 29.5840911502867 3369 841 144 928 641 4587 4583 2947 1085 183 4129 600 M14446 GO_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_REGENERATION.html The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. 36/47 Gene Ontology BP GO:0031102 0.000350874954980543 0.00189823977073818 1035 1328.27272727273 1086 3.1902811639978e-05 82 1.51734297800546 1.87257684315745 1 14.1084784316823 1032 3087 1171 3245 830 1611 1086 82 754 1591 122 601 M16889 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 21/25 Gene Ontology BP GO:1900151 5.49328905596945e-05 0.00048226932032879 100 1327.72727272727 1087 4.99402384129278e-06 41 0.879548432198911 0.915307763207861 1 9.96311586934212 257 1087 3181 2331 97 41 228 1154 2381 3751 97 602 M15905 GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. 44/77 Gene Ontology BP GO:1902930 0.000518805088797268 0.00247839343579131 1040 1459.18181818182 1088 4.71752249161196e-05 453 1.30797361560812 1.06775194457701 1 11.6423289969461 1040 922 453 1088 2058 1132 485 3103 2926 749 2095 603 M11467 GO_REGULATION_OF_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXIT_FROM_MITOSIS.html Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. 23/27 Gene Ontology BP GO:0007096 0.00265209371384092 0.00796141422613019 1090 1799.18181818182 1089 0.000241390564671111 311 0.893162397518882 -0.898344314814113 -1 6.39903145553107 1089 2776 3506 3154 2865 610 807 311 815 3476 382 604 M12013 GO_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. 34/47 Gene Ontology BP GO:0046513 0.00556847895512563 0.0134540021460564 4385 2006.36363636364 1089 0.000507511239057325 470 1.62550009386051 1.82638155820744 1 10.3882437628808 4384 954 1089 719 2270 3459 3731 470 540 853 3601 605 M13972 GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. 12/26 Gene Ontology BP GO:0045073 0.000101759703726535 0.000756370449583973 390 1198.72727272727 1089 9.25131007877197e-06 3 1.41998702170522 1.29175012191755 1 15.1426468684365 390 2371 1275 1944 2834 94 3 1089 1810 891 485 606 M10843 GO_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. 27/41 Gene Ontology BP GO:0033233 0.000584505645474156 0.00272515507854834 1305 1250.81818181818 1090 5.31509997531035e-05 123 0.928926991434164 -0.980969838806071 -1 8.13441293730943 1301 1013 2693 1090 446 1043 1642 123 1696 2500 212 607 M14504 GO_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 468/671 Gene Ontology BP GO:0008610 0.0031552640195637 0.00909630946903959 2335 1382.36363636364 1090 0.00028725440372081 425 1.16311909025794 -1.15958541132424 -1 8.10620150360127 2331 606 827 455 941 1090 3420 2784 1139 425 1188 608 M15221 GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of embryonic development. 140/180 Gene Ontology BP GO:0045995 0.00277203859261198 0.0082417224098553 345 1380.72727272727 1090 0.000252321598520911 90 1.24256456706034 1.18469463502224 1 8.84264069356223 344 2544 684 2681 1090 1039 925 1235 2816 1740 90 609 M15481 GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 75/104 Gene Ontology BP GO:0046916 0.0313900546075423 0.0508912627487436 405 1466.27272727273 1090 0.00289519003628458 403 1.13506611434024 1.17230256483569 1 5.00850739910472 403 1507 1822 2270 3958 841 993 1050 1090 1153 1042 610 M10489 GO_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 204/264 Gene Ontology BP GO:0050808 1.14241123072025e-06 1.91210052393573e-05 430 1322.63636363636 1092 1.03855620359046e-07 211 1.23616498391395 1.16810025411605 1 19.9314803027589 428 1976 211 2021 1092 490 1200 2536 3249 988 358 611 M13873 GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is regionalized in the dorsoventral axis. 17/25 Gene Ontology BP GO:0021904 0.000631770584008588 0.00288481700431007 175 1401.27272727273 1094 5.74501892326311e-05 99 1.0574151222611 -1.02433214249868 -1 9.17163621500108 174 2821 2330 1094 2232 99 858 134 3362 2040 270 612 M15920 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT.html Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. 21/25 Gene Ontology BP GO:0061311 0.00377193335912956 0.0103544577699291 2715 1463.36363636364 1094 0.000343492360158501 320 1.61175387213101 1.68848968750673 1 10.9269812746293 2714 1056 778 1082 651 2064 1972 2343 320 1094 2023 613 M11709 GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glutathione derivative. 18/28 Gene Ontology BP GO:1901687 0.00116545310802287 0.00440524233276231 1240 1583.27272727273 1095 0.00010600645152164 134 0.817313336546022 -0.796221246473637 -1 6.57291328471303 1238 1095 2701 1030 418 134 1077 1354 4354 3141 874 614 M13245 GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. 17/23 Gene Ontology BP GO:2000310 0.00408644358738889 0.0109592057706747 3820 1981 1095 0.000372186713558894 534 1.65291199349608 -1.76737459117657 -1 11.0669752209266 3819 1749 654 534 3832 4274 3349 777 980 728 1095 615 M12449 GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione derivative. 18/28 Gene Ontology BP GO:1901685 0.00116545310802287 0.00440524233276231 1240 1580.90909090909 1096 0.00010600645152164 135 0.817313336546022 -0.796221246473637 -1 6.57291328471303 1239 1096 2702 1031 419 135 1078 1316 4355 3144 875 616 M10972 GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. 21/28 Gene Ontology BP GO:0033032 0.000993067026587814 0.0039549866606215 1100 1968.45454545455 1097 9.03195976976221e-05 131 1.07650339204283 1.0664148493706 1 8.83306531761385 1097 4167 3052 4092 399 785 247 191 3756 3736 131 617 M16714 GO_EXTRACELLULAR_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins. 31/36 Gene Ontology BP GO:0043206 5.3309145871515e-05 0.000474278118050018 10 1637.81818181818 1097 4.84640342474288e-06 9 1.36810140925926 1.43467424253151 1 15.5370819077331 9 3110 469 3184 1765 834 841 1097 4518 1570 619 618 M10649 GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. 77/130 Gene Ontology BP GO:2000106 0.0113200016361948 0.022762302339332 1040 1228.72727272727 1098 0.0010344246609824 337 1.18106422544631 1.07286016882746 1 6.62289245082157 1036 1505 979 2121 1285 729 337 681 2495 1250 1098 619 M16769 GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of tight junction assembly. 19/24 Gene Ontology BP GO:2000810 0.00223682447014292 0.00704191086574763 425 1632.36363636364 1100 0.000203554725273393 77 0.766043423057245 0.710565341665131 1 5.62636955919115 421 1100 2770 1892 1739 769 77 510 4002 3652 1024 620 M14077 GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. 30/40 Gene Ontology BP GO:0046460 0.00577426225782821 0.0134540021460564 4020 1670.36363636364 1101 0.000526315789473684 43 1.28918892224097 -1.53725096972862 -1 8.23674070138285 4017 283 1096 43 1101 3011 3547 1738 460 858 2220 621 M12610 GO_PROTEIN_HETEROTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTETRAMERIZATION.html The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. 18/43 Gene Ontology BP GO:0051290 0.00954170518763405 0.0199719092388939 1435 1225.09090909091 1102 0.000871212902283122 306 1.43521807315641 -1.5230270474047 -1 8.32906801667351 1434 1113 2003 1055 895 1102 618 1898 306 2647 405 622 M14639 GO_HEART_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_DEVELOPMENT.html The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. 39/47 Gene Ontology BP GO:0003170 0.00462469211425399 0.0119019316413848 540 1542.63636363636 1102 0.000421312958054197 276 1.46858930215957 1.56091950115972 1 9.65171890204774 539 3078 1102 3539 1430 736 988 414 3004 1863 276 623 M16472 GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 30/40 Gene Ontology BP GO:0046463 0.00577426225782821 0.0134540021460564 4020 1689.90909090909 1102 0.000526315789473684 44 1.28918892224097 -1.53725096972862 -1 8.23674070138285 4018 284 1097 44 1102 3012 3548 1942 461 860 2221 624 M10999 GO_PEROXISOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 35/36 Gene Ontology BP GO:0007031 0.00338552292575622 0.0095873528605544 1630 1493.54545454545 1103 0.000308249461016742 256 0.792837674904613 -0.666208804689673 -1 5.46028660634943 1628 262 3792 1103 772 256 2150 347 1340 4245 534 625 M14388 GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. 18/28 Gene Ontology BP GO:0014874 0.000152333645036067 0.00103321580537707 625 1128 1103 1.38494721846505e-05 48 1.22543169994574 1.35478146021643 1 12.4989407543286 625 1103 1662 1773 1936 295 183 48 1660 2136 987 626 M16970 GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of stem cell differentiation. 162/226 Gene Ontology BP GO:2000736 1.57756093285881e-05 0.000183969699764211 185 1622.45454545455 1103 1.43415658658024e-06 7 1.20598557171507 1.29743623173403 1 15.3905398487677 185 3981 1192 3865 4017 96 373 7 2915 1103 113 627 M13373 GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. 44/58 Gene Ontology BP GO:0030514 0.00878100158473693 0.0186324729082773 510 1169.45454545455 1104 0.000801476987899669 152 1.35409839752368 1.16492757617636 1 7.99727769052138 506 921 1509 1370 3397 152 802 1283 1104 1516 304 628 M15604 GO_HEME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. 20/21 Gene Ontology BP GO:0006783 2.02725544092697e-05 0.000226750470351759 820 1613.18181818182 1104 1.84297647446932e-06 52 0.697685640029079 -0.742145798873203 -1 8.68263216529629 818 1104 3604 1056 52 821 1349 2289 619 4054 1979 629 M16775 GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 16/17 Gene Ontology BP GO:0010839 0.00180863641348924 0.00609587405331511 160 1620.27272727273 1104 0.000164556820052126 67 1.04896639227227 1.15031864257236 1 7.9329975996217 156 2329 2554 3241 583 169 67 1104 3984 3010 626 630 M13734 GO_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_BURST.html A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 18/26 Gene Ontology BP GO:0045730 0.00805887676696859 0.0174409086496302 825 1102 1105 0.00073532270295354 401 1.0648367076471 1.06234222271616 1 6.39111712312574 825 1120 1729 2084 1105 684 401 578 1454 1601 541 631 M16180 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 130/173 Gene Ontology BP GO:0090101 0.00132813753107018 0.00488910121208035 340 1558.27272727273 1106 0.000120812727683854 23 1.2032557110975 1.1593856238776 1 9.49554393377673 336 2982 1106 2907 4080 23 615 604 3057 1380 51 632 M14714 GO_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_HOMEOSTASIS.html Any process involved in the balance between food intake (energy input) and energy expenditure. 19/20 Gene Ontology BP GO:0097009 0.000246746389839059 0.0014738266391799 580 1280.36363636364 1109 2.24340062391959e-05 106 1.09664748799271 1.05260294049023 1 10.6059078543554 577 1109 2045 3233 208 538 106 309 2891 1737 1331 633 M13787 GO_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell. 134/260 Gene Ontology BP GO:0050707 7.45336439715212e-05 0.000599254438276232 545 1467 1110 6.77601538284849e-06 177 1.31744964699039 1.44476063016871 1 14.5039139327893 544 2549 334 2303 4487 806 1110 177 1740 404 1683 634 M16879 GO_INOSITOL_LIPID_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_LIPID_MEDIATED_SIGNALING.html A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. 120/158 Gene Ontology BP GO:0048017 0.00577426225782821 0.0134540021460564 1110 1563.54545454545 1110 0.000526315789473684 8 1.17490154315656 1.14087965222092 1 7.5056033894507 1110 8 1086 221 4537 1030 1590 3092 1231 748 2546 635 M10659 GO_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 120/162 Gene Ontology BP GO:0042157 0.00321811772081828 0.00923744710361966 1595 1578.90909090909 1112 0.00029298498040437 10 0.88912268150739 -0.828558987296032 -1 6.17378192178701 1592 10 3195 125 607 138 1112 2999 2964 3951 675 636 M13399 GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. 17/30 Gene Ontology BP GO:0033630 0.00926220248308461 0.0194744817685462 3455 2066.09090909091 1112 0.000845584418861519 234 1.66202831583552 -1.53205606863181 -1 9.70925455411334 3455 1112 1026 556 3938 3180 3663 607 234 729 4227 637 M13750 GO_GLYCINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycine, aminoethanoic acid. 11/20 Gene Ontology BP GO:0006544 0.0199596967442056 0.0354972463265076 595 1654.09090909091 1112 0.00183119244401647 353 1.49988646467944 -1.49988646467944 -1 7.42398672433816 595 3917 2912 1112 2431 1026 801 865 353 2478 1705 638 M15793 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 20/22 Gene Ontology BP GO:0061003 0.000687550444592829 0.00305556085834807 460 929.090909090909 1112 6.25241285394295e-05 323 1.19499250761306 1.34033003437471 1 10.2642912339723 456 406 1700 1281 337 1112 736 323 1265 1394 1210 639 M12201 GO_TAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAXIS.html The directed movement of a motile cell or organism in response to an external stimulus. 410/733 Gene Ontology BP GO:0042330 1.98432347844723e-18 1.15413214315187e-15 490 1388.27272727273 1113 1.80393043495202e-19 6 1.42719136829783 1.43277971777737 1 72.8779447260872 490 2944 6 2251 3209 397 1113 1422 2480 22 937 640 M11978 GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 211/267 Gene Ontology BP GO:0008654 0.00577426225782821 0.0134540021460564 1570 1128.72727272727 1114 0.000526315789473684 46 1.03543860994001 -1.05445442190636 -1 6.61340903760704 1569 684 2996 46 1114 156 1793 1195 392 2117 354 641 M16302 GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 126/167 Gene Ontology BP GO:0071260 0.000299562226606173 0.00170816549068446 470 1845.81818181818 1114 2.7236638560811e-05 73 1.13393238493252 1.24910625236641 1 10.7184178253633 468 2985 612 4280 3354 921 1114 73 3602 2263 632 642 M10104 GO_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DEVELOPMENT.html The progression of an endothelial cell over time, from its formation to the mature structure. 64/70 Gene Ontology BP GO:0001885 0.0111645672682027 0.0225178723445805 465 1208.09090909091 1115 0.00102014828070107 122 1.09616579371243 1.16509674780499 1 6.1636251497784 462 122 1907 851 934 1115 545 1306 2202 2421 1424 643 M16203 GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 28/38 Gene Ontology BP GO:0071549 1.06441604784874e-05 0.000134567861304248 1115 1137.63636363636 1115 9.67655634363309e-07 30 1.18266762382742 1.23032893614735 1 15.6418792035124 1112 1007 1535 1776 30 449 555 1163 2051 1721 1115 644 M14048 GO_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. 546/697 Gene Ontology BP GO:0001944 2.9143997252854e-09 1.09360499368976e-07 660 1650.54545454545 1116 2.91439972910758e-10 43 1.31420666003991 1.36154876788951 1 31.2671531318335 659 1910 4470 2740 2193 914 1116 663 2834 43 614 645 M14268 GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY.html Any process that modulates the activity of the enzyme phospholipase A2. 24/30 Gene Ontology BP GO:0032429 0.00107802065205428 0.00418564404019528 4445 1589.54545454545 1116 9.80499322688715e-05 330 1.38648342376918 -1.57834721554069 -1 11.2629304593246 4442 330 510 883 1012 3610 1959 1529 1116 722 1372 646 M14034 GO_SYNAPTIC_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_SIGNALING.html Cell-cell signaling to or from a synapse. 337/577 Gene Ontology BP GO:0099536 9.67139153721758e-10 4.05414277681742e-08 2275 1442.09090909091 1120 8.79217412860835e-11 81 1.2885515571511 1.2937217422661 1 32.5551639164414 2272 633 81 457 1107 1120 2632 3057 1729 240 2535 647 M14929 GO_HEART_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_PROCESS.html A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 101/167 Gene Ontology BP GO:0003015 0.00154690952943053 0.00546113053144177 285 1910.54545454545 1120 0.000140727117854747 56 1.17360169281918 1.19439822437428 1 9.06845125659139 281 2993 1120 3727 4380 1056 989 994 3302 2118 56 648 M15515 GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 34/58 Gene Ontology BP GO:0071470 0.00604194999971946 0.0138967836622317 1605 1401.72727272727 1121 0.000550782484988506 208 1.07298485863803 1.11309179855684 1 6.80201674469131 1605 958 1679 1753 783 1121 669 3219 2570 854 208 649 M16709 GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 328/469 Gene Ontology BP GO:0071214 0.00403702820044025 0.0108579723795656 1090 1266.63636363636 1121 0.000367677753297316 640 1.10199226940059 1.19002079438116 1 7.38995559019611 1087 640 652 1843 1121 773 1134 996 3230 1203 1254 650 M16960 GO_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. 174/259 Gene Ontology BP GO:0048592 7.71645157289904e-08 1.96200268681417e-06 570 1387 1121 7.01495622141083e-09 137 1.22045618277605 1.16698673872904 1 23.8040496515863 568 1996 137 809 1638 703 1121 3766 2702 461 1356 651 M12232 GO_FATTY_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. 50/61 Gene Ontology BP GO:0035337 2.15697247959712e-05 0.000238394131771149 2445 1706.72727272727 1122 1.96090329795664e-06 54 1.05034881498478 1.13634401851779 1 12.9987852767725 2445 157 1122 682 54 2597 3291 2789 871 646 4120 652 M10473 GO_REGULATION_OF_T_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. 7/13 Gene Ontology BP GO:0010819 0.00193452752815783 0.00638847167389523 655 1470.09090909091 1123 0.000193621367293116 380 2.05735528169317 -2.2180969669333 -1 15.4261518043807 2016 1860 4242 1085 529 1852 1777 654 380 1123 653 653 M13622 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 13/15 Gene Ontology BP GO:0010867 1.22625617703543e-05 0.000150548020890392 2945 1590.36363636364 1123 1.11478455646174e-06 7 1.55966524362114 -1.34237400807074 -1 20.3715540434755 2944 2363 2801 1046 33 874 2795 807 7 2701 1123 654 M15284 GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS.html Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. 13/15 Gene Ontology BP GO:0051457 1.2803911873882e-05 0.000155959690966421 1040 1647 1123 1.16399876297667e-06 35 0.81560036514588 -0.84499399265614 -1 10.6051022277112 1037 3220 3222 1605 35 1123 1786 1025 678 3293 1093 655 M16621 GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. 17/24 Gene Ontology BP GO:0043011 0.000476590319093425 0.00235161691913224 2370 1434.45454545455 1123 4.33357813739366e-05 101 1.2321384321332 -1.31515984989834 -1 11.0627617073879 2368 1123 1813 547 3373 566 2889 101 653 1486 860 656 M15408 GO_OUTFLOW_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. 67/92 Gene Ontology BP GO:0003151 0.000131398372098189 0.00093342996240133 805 1656.63636363636 1124 1.19460200657867e-05 363 1.4717272833614 1.41929241371775 1 15.2351531492262 803 852 363 2629 2181 1124 464 4485 3113 1727 482 657 M15035 GO_NEUROTRANSMITTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 23/41 Gene Ontology BP GO:0042133 0.0104160374674007 0.0213317879999187 2645 1704.63636363636 1126 0.000951425656877309 355 1.21544087077556 -1.37792556729234 -1 6.93311191477157 2644 355 1168 513 3903 730 1126 652 4164 3061 435 658 M11614 GO_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_KETONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 62/102 Gene Ontology BP GO:0042180 0.00762515387208258 0.0166881610669546 325 2033.09090909091 1127 0.000695610132039938 220 1.0756762040362 -1.01600949406948 -1 6.52675064047898 325 4032 2920 3497 832 220 980 1127 3952 3981 498 659 M13080 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. 11/18 Gene Ontology BP GO:2000258 0.000149715529092895 0.00102595928846722 290 1208.36363636364 1128 1.36114289619745e-05 32 1.05001802570384 1.11411537974382 1 10.7192497281007 290 1839 1373 1506 1128 203 32 47 4132 2474 268 660 M13657 GO_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE.html The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. 396/732 Gene Ontology BP GO:0006954 5.52049261822505e-22 8.56228405086706e-19 200 1324 1128 5.01862965293187e-23 3 1.47389569474732 1.50748471513401 1 91.0341225573131 197 1928 3 2242 4575 822 1128 541 1944 30 1154 661 M10354 GO_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_GASEOUS_EXCHANGE.html The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. 47/68 Gene Ontology BP GO:0007585 0.000391348172673031 0.00203230250831207 270 1054.54545454545 1129 3.55834368357465e-05 175 1.256862275643 1.25281908198422 1 11.5573043054159 1552 175 601 267 269 1565 675 1312 2217 1129 1838 662 M10072 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY.html Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 120/138 Gene Ontology BP GO:0090175 0.00124883761426777 0.00466734250537183 1700 1454.54545454545 1130 0.000113595189559352 2 1.00296632855365 -0.865436378114533 -1 7.98230504953271 1698 2 2862 113 430 633 1130 3701 365 2851 2215 663 M13575 GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. 106/151 Gene Ontology BP GO:1901343 2.4618995833892e-07 5.18335690566062e-06 155 1438.54545454545 1130 2.23809078080632e-08 151 1.47914596948356 1.47186626033133 1 26.7181949410529 151 2991 169 3366 1385 1130 1150 1060 3420 530 472 664 M15419 GO_HYDROGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_TRANSPORT.html The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 113/157 Gene Ontology BP GO:0006818 0.0132539707510569 0.0256533801600116 165 1455.18181818182 1130 0.001212227250697 17 0.879320990515971 -0.741071673524458 -1 4.77200890036685 165 17 3368 485 3863 226 371 1130 1192 3829 1361 665 M12214 GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. 15/23 Gene Ontology BP GO:0034104 0.00185629617427485 0.00622259271481621 3405 1780.09090909091 1131 0.000168896755987149 254 1.67781410801557 -1.56705139872707 -1 12.6439075403942 3403 1131 681 545 1422 4380 3803 254 360 572 3030 666 M16851 GO_ESTROUS_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROUS_CYCLE.html A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. 16/25 Gene Ontology BP GO:0044849 5.97727639512517e-05 0.000510675269384426 585 1077.27272727273 1131 5.43403527322185e-06 104 1.27693153841321 0.978077292811612 1 14.3607926302799 585 1137 1504 1818 104 1131 624 776 256 2460 1455 667 M14126 GO_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_METABOLIC_PROCESS.html The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 194/392 Gene Ontology BP GO:0008202 0.000572157789975939 0.00267968427588706 2750 1380.45454545455 1132 5.20278769308628e-05 40 1.25814869978414 -1.20783864255045 -1 11.0525492227516 2746 694 457 40 391 1389 4357 1845 1248 1132 886 668 M14969 GO_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of MAP kinase activity. 371/484 Gene Ontology BP GO:0043405 0.00261135985447444 0.00787146392834051 920 1385 1132 0.000237678604697171 473 1.17019527592564 1.17768246112673 1 8.40687427856034 918 1356 611 1132 3458 711 900 2122 2191 473 1363 669 M10433 GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of endocytosis. 135/190 Gene Ontology BP GO:0045807 0.000455017684815249 0.00228623496394876 910 1260.36363636364 1133 4.13738019692986e-05 442 1.24610799704481 1.30321902526478 1 11.2404797795449 907 750 442 771 1345 1133 2007 1621 2752 649 1487 670 M14001 GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the Notch signaling pathway. 68/96 Gene Ontology BP GO:0008593 0.00584666425865934 0.0135683435389237 1135 1765.27272727273 1133 0.000532932751178002 485 1.27774925387715 1.28505458685212 1 8.14750111715588 1133 3696 733 3903 1372 1011 1070 485 3641 1258 1116 671 M14150 GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The regulation of blood pressure mediated by detection of stimuli and a neurological response. 15/22 Gene Ontology BP GO:0001976 0.00733169654654013 0.0162021781295408 3340 1534.54545454545 1133 0.000668749517214132 99 1.88836871399506 -2.06735939982376 -1 11.5487490282688 3339 1133 742 331 2164 1989 2724 910 99 850 2599 672 M10708 GO_EMBRYONIC_DIGIT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGIT_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. 74/89 Gene Ontology BP GO:0042733 0.0249696152244698 0.0426018954950089 2235 1552.45454545455 1134 0.00229614568771999 352 1.16766279025091 -1.21136563277555 -1 5.46090047071513 2235 823 1259 1043 4598 352 2249 979 1083 1322 1134 673 M15587 GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS.html The process in which any suture between cranial and/or facial bones is generated and organized. 16/20 Gene Ontology BP GO:0097094 0.00232339815712594 0.00723612558574764 1135 1122.36363636364 1134 0.000211441409898063 507 1.40667653183742 -1.41322507900956 -1 10.2837281397535 2033 1134 1135 1491 547 765 1231 540 2003 960 507 674 M16078 GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of B cell activation. 70/210 Gene Ontology BP GO:0050871 0.00238917740944212 0.00734754956122551 1675 1645.81818181818 1134 0.000217434180297195 106 1.14612644618391 1.13247677405065 1 8.35095596480373 1675 106 999 570 4393 1529 1005 297 3759 1134 2637 675 M10215 GO_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 868/1225 Gene Ontology BP GO:1901698 4.08896042604846e-07 8.02781977316603e-06 1005 1502.54545454545 1135 4.08896117843054e-08 92 1.15864008806261 1.17658199639579 1 20.1739050236105 1004 1299 4232 738 2641 687 1135 1112 1850 92 1738 676 M10581 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. 31/36 Gene Ontology BP GO:2000108 0.00189608364728185 0.00630176943628747 1245 1126.81818181818 1135 0.000172519979383936 251 1.35964756984086 1.25531110735536 1 10.2186755181542 1244 1641 1091 1397 504 739 251 888 2264 1241 1135 677 M13793 GO_REGULATION_OF_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION.html Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. 28/63 Gene Ontology BP GO:0051931 0.000176720878635657 0.0011404746855641 1005 1454.09090909091 1137 1.60668250735521e-05 210 1.61185823382391 1.68126797683837 1 16.2073217871376 1474 1001 383 1816 1137 3049 3062 210 2498 1004 361 678 M15571 GO_RESPONSE_TO_SALT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. 12/19 Gene Ontology BP GO:1902074 0.00104549188517422 0.00410174851746683 1140 1201.63636363636 1137 9.50899143983982e-05 37 1.59254943465608 1.54169787538762 1 12.9863454616998 1137 1208 1735 229 3879 1890 37 329 187 895 1692 679 M16918 GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN.html Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. 28/63 Gene Ontology BP GO:0051930 0.000176720878635657 0.0011404746855641 1475 1449.36363636364 1138 1.60668250735521e-05 146 1.61185823382391 1.68126797683837 1 16.2073217871376 1475 1002 384 1817 1138 3050 3063 146 2499 1007 362 680 M12538 GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. 63/94 Gene Ontology BP GO:0003229 0.00133468171963171 0.00490155804376192 320 1232.81818181818 1139 0.000121408374915336 317 1.28580934262866 1.26587806037106 1 10.1428927619777 317 857 531 1139 1568 2053 1765 1646 2362 822 501 681 M11308 GO_REGULATION_OF_HEAT_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEAT_GENERATION.html Any process that modulates the rate or extent of heat generation. 14/18 Gene Ontology BP GO:0031650 0.000248167743181902 0.0014785204981119 95 1506.72727272727 1140 2.25632492544155e-05 7 1.64802148786613 1.39511451309676 1 15.9359415228128 91 2866 1145 2342 3977 148 7 118 4480 1140 260 682 M12883 GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS.html The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 13/31 Gene Ontology BP GO:0009072 0.000321777905239944 0.00179955840514599 1730 1350.18181818182 1140 2.92568162708679e-05 76 2.29857670220116 -2.6635115355741 -1 21.5601997650128 1728 3228 2128 1600 1140 677 836 76 789 2100 550 683 M13393 GO_MUSCLE_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_MORPHOGENESIS.html The process in which the anatomical structures of muscle are generated and organized. 82/133 Gene Ontology BP GO:0048644 7.28209761777141e-05 0.000588256948185597 195 1340.09090909091 1141 6.62030788145847e-06 54 1.32479031119549 1.38625681590609 1 14.6212226110275 193 2092 333 2429 2306 1141 1357 905 3216 715 54 684 M11151 GO_POSITIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. 468/658 Gene Ontology BP GO:0043410 4.04080879295706e-10 1.89918013268982e-08 980 1285.72727272727 1142 3.67346253972659e-11 72 1.21463095636025 1.254933623811 1 32.0545936695538 980 1338 72 484 2872 607 1142 2423 2510 169 1546 685 M16293 GO_UTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. 9/13 Gene Ontology BP GO:0046051 0.00107317247155185 0.00417165539693464 710 1704.72727272727 1143 0.000107369108869729 150 0.845094356440424 -0.845094356440424 -1 6.86505898364152 709 2908 4613 2097 421 807 1143 832 150 3555 1517 686 M10997 GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that activates or increases the frequency, rate, or extent of cellular extravasation. 10/16 Gene Ontology BP GO:0002693 0.00142558818488625 0.00514206342967112 865 1168.63636363636 1144 0.000129682981571285 78 1.98884262893705 2.19924486040299 1 15.5530266307587 861 2401 1517 1487 454 1144 78 496 1679 2311 427 687 M16438 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 14/17 Gene Ontology BP GO:0032230 0.000654461558962368 0.0029565142076232 3730 1919.90909090909 1144 5.95142119057476e-05 329 1.53892844179491 -1.67684587395601 -1 13.2968673132238 3729 1144 608 473 329 4439 3633 3375 534 774 2081 688 M11970 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 16/37 Gene Ontology BP GO:0050716 0.000781499177924006 0.00334162763686406 2230 1293.72727272727 1146 7.10706295992939e-05 151 1.87269839715905 2.0662931092529 1 15.8425852558192 2226 1146 939 1282 817 1955 2333 151 349 642 2391 689 M13485 GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. 355/457 Gene Ontology BP GO:0071902 0.00117720142713779 0.0044388316373356 785 1398 1147 0.000107075619088307 180 1.17473663363269 1.21145523304187 1 9.43875969667397 782 1360 523 1147 3252 180 695 2734 2765 732 1208 690 M14911 GO_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of neuron death. 312/401 Gene Ontology BP GO:1901214 0.0692990304664585 0.0982774729534993 820 1312.63636363636 1148 0.00650757397916411 431 1.13566787592414 1.15458790723049 1 3.9014255719799 1148 648 1790 431 2131 818 816 2067 1081 1204 2305 691 M16507 GO_PROTEIN_AUTOPROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPROCESSING.html Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. 10/19 Gene Ontology BP GO:0016540 0.00560831045563564 0.0134540021460564 1585 1232.18181818182 1148 0.000511150779436138 206 1.5587577947916 -1.70822338514844 -1 9.96126936269457 1581 2399 1951 826 989 2058 206 474 269 1653 1148 692 M14868 GO_MAST_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a mast cell. 21/51 Gene Ontology BP GO:0002448 0.0029100193252724 0.00855358175647029 675 1688.36363636364 1149 0.000264897786902098 275 1.12990837044531 1.17116774136618 1 7.97765062555609 674 1090 1622 3053 4543 1149 275 322 3516 1459 869 693 M15453 GO_REGULATION_OF_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_SPECIFICATION.html Any process that mediates the adoption of a specific fate by a cell. 14/24 Gene Ontology BP GO:0042659 1.79080451904232e-05 0.00020473251663646 1150 1231.27272727273 1149 1.62801736035819e-06 46 1.52780976566642 1.45025680362774 1 19.2578572999366 1672 1147 1118 1311 46 2179 1092 2260 216 1149 1354 694 M11757 GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of phospholipid metabolic process. 79/120 Gene Ontology BP GO:1903725 0.0218036936364138 0.0379687823690993 685 1416.72727272727 1150 0.00200207560728332 91 1.05454354076348 1.15709470203789 1 5.11111336987283 685 91 1241 1150 4341 667 404 1990 2184 916 1915 695 M10229 GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. 168/229 Gene Ontology BP GO:0043524 0.0181032403089371 0.0328399131218263 915 1205.72727272727 1151 0.00165944966570968 544 1.18501334773788 1.20740297935872 1 6.00013201343697 914 1414 1990 1402 1625 650 544 825 1151 1121 1627 696 M14307 GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. 95/122 Gene Ontology BP GO:0006081 0.000509432159726833 0.00244895129591405 590 1240.63636363636 1152 4.63227420119092e-05 298 1.17800251514545 -1.18502480869915 -1 10.5052944292946 590 2063 1972 950 298 417 1536 1152 2419 1198 1052 697 M15534 GO_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERAD_PATHWAY.html The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. 91/99 Gene Ontology BP GO:0036503 9.3880445922642e-06 0.000121678472110878 680 1713 1152 8.53462241276406e-07 26 0.805161736312438 -0.813434474674847 -1 10.7659828198445 677 1479 3855 649 26 733 1493 937 3890 3952 1152 698 M13090 GO_CARDIAC_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_MORPHOGENESIS.html The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 84/124 Gene Ontology BP GO:0003208 0.00070274789908741 0.00309122433779457 210 1372.09090909091 1153 6.39065889904247e-05 28 1.41334066690546 1.51399988773508 1 12.1173713567506 210 3006 473 2234 2153 1153 1333 716 2662 1125 28 699 M16051 GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE.html The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. 191/250 Gene Ontology BP GO:0048754 1.58679812681219e-10 8.48663411960589e-09 560 1358.90909090909 1154 1.44254375175149e-11 62 1.36034825551144 1.35738909013955 1 37.5284584818035 558 2523 62 1369 3076 559 1154 2645 2385 222 395 700 M11102 GO_PENTOSE_PHOSPHATE_SHUNT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_PHOSPHATE_SHUNT.html The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. 15/16 Gene Ontology BP GO:0006098 0.000228603091967054 0.00139477234969959 1155 1074.63636363636 1155 2.07842590621842e-05 34 1.08641280750646 -1.19776924597229 -1 10.595760468506 1155 460 2257 64 201 1593 2973 268 34 1260 1556 701 M12513 GO_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 18/33 Gene Ontology BP GO:0042417 0.00387938876055108 0.0105498514920188 1095 1672.72727272727 1155 0.000353295131761463 381 1.24940295168112 1.27354800479348 1 8.43332307196516 1093 1116 1150 2505 3155 2324 1660 381 3047 814 1155 702 M14331 GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 61/118 Gene Ontology BP GO:0030816 0.000896736773926539 0.00366653445437626 1075 1531.45454545455 1155 8.15547726719343e-05 492 1.31508328969856 1.21594713908225 1 10.9409318553611 1074 2128 492 1780 3060 819 1183 912 3267 1155 976 703 M15345 GO_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. 38/91 Gene Ontology BP GO:0048663 0.000595121174939892 0.00275532221591574 610 1692.36363636364 1155 5.41165656308825e-05 25 1.14542667795226 1.1411796234777 1 10.0140152072546 608 3079 1155 4031 1993 115 25 1951 3790 1116 753 704 M10474 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE.html Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. 19/21 Gene Ontology BP GO:0090178 0.00577426225782821 0.0134540021460564 955 1414 1159 0.000526315789473684 74 1.36743992742172 1.21975883279936 1 8.73734041801115 953 400 1589 181 4424 1150 1271 2107 74 2246 1159 705 M12547 GO_ETHANOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. 13/17 Gene Ontology BP GO:0006067 0.000409774414338109 0.00211149540411431 1425 1451.09090909091 1159 3.72591599344629e-05 287 1.28856423648768 -1.40351153301686 -1 11.7759445491661 1422 1159 783 1713 2959 748 1027 4076 592 287 1196 706 M12634 GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). 30/46 Gene Ontology BP GO:0007205 0.00359496703229431 0.00999246212739869 2915 1719.63636363636 1159 0.000327350450510753 35 1.45273798586392 -1.17045468164677 -1 9.92463331229864 2911 972 911 733 3138 3141 3694 361 35 1159 1861 707 M10502 GO_FOCAL_ADHESION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOCAL_ADHESION_ASSEMBLY.html The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. 38/40 Gene Ontology BP GO:0048041 0.0013966585238407 0.00506915141297251 340 1072.09090909091 1160 0.000127049634006328 213 1.11143615123206 1.1955260077436 1 8.71044950231972 338 1605 2101 1254 1795 901 1160 213 477 1419 530 708 M11908 GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). 20/31 Gene Ontology BP GO:1901071 9.73260608195969e-06 0.000124754314323302 1160 1150.45454545455 1160 8.84786285310709e-07 27 1.23883004621433 -0.916034675056829 -1 16.5244733556575 1160 1716 2172 980 27 407 1625 1516 248 1843 961 709 M12862 GO_PROTEIN_O_LINKED_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_MANNOSYLATION.html The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. 16/16 Gene Ontology BP GO:0035269 0.0105776267242247 0.0215772455711607 845 2161.54545454545 1160 0.000966257188125725 680 0.609803621455093 -0.609803621455093 -1 3.46276649399149 845 4192 3736 3943 921 847 979 680 2562 3912 1160 710 M13284 GO_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions within an organism or cell. 53/98 Gene Ontology BP GO:0055081 0.000189407154776765 0.00120397744696214 3740 1987.45454545455 1161 1.72203148720598e-05 136 1.3524031410702 -1.2214913260182 -1 13.4879600498834 3738 136 389 278 799 4018 3501 3248 1161 496 4098 711 M13357 GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS.html A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 18/28 Gene Ontology BP GO:0097067 0.0397963714968316 0.0620135688462015 2140 1243 1161 0.00368500310350852 246 1.43692566286237 1.28751445004162 1 5.9215761558302 2139 414 1161 327 1435 1845 1108 1158 246 1187 2653 712 M14304 GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction. 38/40 Gene Ontology BP GO:0007045 0.00375146875404901 0.0103104454297638 340 1088 1161 0.000341625556460379 339 1.11143615123206 1.1955260077436 1 7.53876724813097 339 1606 2102 1255 1796 902 1161 378 478 1420 531 713 M12103 GO_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_EFFLUX.html The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 18/31 Gene Ontology BP GO:0033344 0.000842462396831904 0.00351567491700345 2395 1311 1165 7.6616834572543e-05 363 1.58882371310618 -1.62586750383398 -1 13.3196748151066 2395 1115 1165 575 373 1495 2850 363 1695 1597 798 714 M14424 GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. 27/29 Gene Ontology BP GO:0031442 0.00051915594294415 0.00247839343579131 1165 1661.45454545455 1165 4.72071358035812e-05 220 0.707813622404102 0.713930933298229 1 6.29538670685548 1165 1669 3629 2845 305 310 220 881 2691 4173 388 715 M15200 GO_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. 80/124 Gene Ontology BP GO:0019218 0.00108289235502443 0.00419891510660724 1050 1664.54545454545 1166 9.84932498196713e-05 85 1.21293574061191 1.07010078192938 1 9.84610091635948 1047 85 511 1252 3799 1028 666 4501 1863 1166 2392 716 M10397 GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 168/214 Gene Ontology BP GO:0046488 0.00577426225782821 0.0134540021460564 2330 1393.81818181818 1167 0.000526315789473684 92 0.956067789285534 -0.951169407137584 -1 6.10564546017559 2330 715 2612 92 872 255 2705 1540 1167 2866 178 717 M12814 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. 23/35 Gene Ontology BP GO:0045987 0.00603758180158633 0.0138936044128492 385 1443.63636363636 1168 0.000550383183018243 382 1.41172261886439 1.39835515255048 1 8.95323666338657 382 2771 722 3256 1252 710 390 493 3463 1273 1168 718 M16485 GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin receptor signaling. 61/96 Gene Ontology BP GO:0046626 0.00192679838063705 0.00637652408613387 270 1702.63636363636 1168 0.000175317088756803 62 0.989562143852328 1.00581147990611 1 7.41700236081888 270 2623 2467 4174 1168 189 286 374 3996 3120 62 719 M15775 GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 116/203 Gene Ontology BP GO:0043271 0.00106961116988804 0.00416477052174814 1050 1331 1169 9.72846868238825e-05 508 1.10729843889742 1.10008894154139 1 9.00107769566297 1046 767 508 1804 1736 623 1169 2225 2262 775 1726 720 M10536 GO_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CHEMOTAXIS.html The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). 146/236 Gene Ontology BP GO:0060326 2.33815413431931e-10 1.20882568744308e-08 295 1469 1170 2.12559466778892e-11 64 1.49871470189392 1.44832188739174 1 40.5595172085575 294 2540 64 2039 4283 425 1111 1170 2969 86 1178 721 M16140 GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 81/144 Gene Ontology BP GO:0002285 0.0419714104418559 0.0647308494484439 1175 1129.90909090909 1171 0.00389038173446668 374 1.17965644543522 1.06797548071418 1 4.78434330642021 1171 810 1219 374 2052 664 586 1697 471 1209 2176 722 M11506 GO_TOOTH_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOOTH_MINERALIZATION.html The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. 28/32 Gene Ontology BP GO:0034505 0.00191885567408492 0.00635475832848195 30 1715.18181818182 1172 0.000174593760017792 28 1.2458508849826 1.16541822263423 1 9.3470338764282 28 3460 565 3176 1172 881 823 2069 3914 1711 1068 723 M13966 GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of T cell proliferation. 66/104 Gene Ontology BP GO:0042130 0.0425721403571075 0.065474890074466 1030 1242.81818181818 1172 0.0039471805205071 128 1.17015221154118 -1.22276155029893 -1 4.72585368572305 1029 128 1708 583 2268 1082 2021 1190 1750 1172 740 724 M11723 GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS.html Any process that modulates levels of neurotransmitter. 184/285 Gene Ontology BP GO:0001505 0.000535608431525661 0.00254480597466169 3975 1714.81818181818 1173 4.87035340316498e-05 51 1.22669594932815 -1.37663308407041 -1 10.8700446521238 3973 709 454 51 1173 3698 4271 1668 1346 585 935 725 M12376 GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. 46/52 Gene Ontology BP GO:0061098 0.0316699436808983 0.0512316754520936 1640 1663.09090909091 1174 0.00292138647142374 806 1.36034342844951 1.48355575902626 1 5.9911993557411 1636 917 987 1087 2032 2959 2875 1174 806 830 2991 726 M13232 GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. 47/68 Gene Ontology BP GO:0033628 0.00131194333939077 0.00485252174736507 530 1302.36363636364 1176 0.000119338759518079 529 1.36069776578454 1.39036359659237 1 10.7545730046032 1176 1577 529 633 4203 1206 1443 529 1563 698 769 727 M15536 GO_MYELIN_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_MAINTENANCE.html The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. 12/14 Gene Ontology BP GO:0043217 0.000221594023694848 0.00136566489040017 2185 1353.09090909091 1177 2.01469406184081e-05 196 1.01712239949573 1.19326555559193 1 9.95114352273284 2184 1177 2494 571 196 2607 715 476 223 2585 1656 728 M11388 GO_MONOVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 289/504 Gene Ontology BP GO:0015672 1.80043632874859e-09 7.16019678433094e-08 1980 1433.63636363636 1179 1.63676030020185e-10 87 1.24132867065063 -1.21550915668627 -1 30.3133030218208 1979 647 87 246 4493 504 1967 2691 1179 260 1717 729 M14288 GO_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_POLYMERIZATION.html Assembly of actin filaments by the addition of actin monomers to a filament. 28/38 Gene Ontology BP GO:0030041 0.00393866782770078 0.0106736292383761 2365 1297.27272727273 1179 0.000358703360303842 278 1.42762086583828 -1.51719000506074 -1 9.6130681961047 2365 1656 1778 1021 663 1448 1916 1179 961 1005 278 730 M12067 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 13/15 Gene Ontology BP GO:0040037 0.0175490687878505 0.0320470239677663 4590 2027.90909090909 1180 0.00160823987336403 615 1.48731555774207 -1.64549623779985 -1 7.58748691897261 4586 1180 1038 615 2124 2528 4230 815 622 1021 3548 731 M14476 GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a cardiac muscle cell. 41/74 Gene Ontology BP GO:0086001 0.00618370467740731 0.0141737821990031 210 2258.90909090909 1180 0.00056374130761972 155 1.15656805782011 0.98691820468731 1 7.29881608908034 208 4408 1123 4553 3550 1180 811 908 4340 3612 155 732 M14600 GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS.html Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. 47/64 Gene Ontology BP GO:0097006 0.0031366569303926 0.00904927079265847 3745 2345 1180 0.000285557997805221 624 1.50396801254175 1.41856168257896 1 10.4964046660794 3744 908 624 1015 900 4353 3739 4164 1180 699 4469 733 M13764 GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. 13/27 Gene Ontology BP GO:0060219 0.0018188258522876 0.00611046692468894 3160 1761.90909090909 1181 0.000165484662666407 496 2.0024930572565 -2.57951485928756 -1 15.146798230263 3157 1181 579 965 496 1926 1122 3106 912 1501 4436 734 M11591 GO_IRON_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_TRANSPORT.html The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/73 Gene Ontology BP GO:0006826 0.0416565233433106 0.0643091583000744 970 1417.90909090909 1182 0.00386062221112729 512 1.03059051234527 1.19035356973446 1 4.18842935559545 969 882 2655 1269 3229 512 1182 1785 755 1724 635 735 M15117 GO_EPITHELIAL_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MORPHOGENESIS.html The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. 53/69 Gene Ontology BP GO:0003382 0.0191389537667753 0.0343570801993847 1445 1280.45454545455 1182 0.00175522818861597 182 1.33465860133158 1.24427673196486 1 6.66968182234217 1443 182 1134 1020 1109 1182 1239 2907 713 1217 1939 736 M11524 GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 11/20 Gene Ontology BP GO:0019370 6.39996375328426e-05 0.000537527641589019 1520 1369.90909090909 1184 5.81831812779677e-06 109 2.1521466008886 -1.84535205552216 -1 24.04729660209 1520 1840 1184 505 109 928 2066 3950 168 795 2004 737 M12941 GO_CHROMATIN_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DISASSEMBLY.html The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. 22/41 Gene Ontology BP GO:0031498 0.00759000523799067 0.016635089200363 575 1676.54545454545 1184 0.000692392541152512 184 0.921208245385389 -0.921208245385389 -1 5.59232982207872 575 2282 3259 3022 2406 536 1024 1184 548 3422 184 738 M14093 GO_VENTRICULAR_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_DEVELOPMENT.html The progression of the ventricular septum over time from its formation to the mature structure. 67/78 Gene Ontology BP GO:0003281 0.0356676329916662 0.056738973097512 1240 1193.09090909091 1184 0.00329630655313181 108 1.37621498292223 1.4154598384489 1 5.85258240349621 1240 108 1019 416 2515 1184 2157 1949 278 990 1268 739 M11254 GO_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. 137/165 Gene Ontology BP GO:0051340 0.0465292484591201 0.0702467855549273 170 1533.18181818182 1185 0.00432213523145774 166 0.696370636865037 -0.701517104873467 -1 2.73535193104671 166 742 4134 407 1511 548 791 1445 1673 4263 1185 740 M12173 GO_EMBRYO_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT.html The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. 893/1244 Gene Ontology BP GO:0009790 0.00022776939600386 0.00139265571564515 615 1467.36363636364 1187 2.27792744876087e-05 263 1.1677109931247 1.17203092754642 1 11.3920910176339 612 1297 4352 1187 2478 429 1031 1827 1997 263 668 741 M14938 GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase B. 27/37 Gene Ontology BP GO:0032148 0.000404617133947509 0.00208954886155134 4465 1600.90909090909 1188 3.67901426395022e-05 272 1.45447603064608 -1.61394186941585 -1 13.3161184411319 4465 1012 1188 576 272 3032 2594 904 473 1255 1839 742 M14824 GO_HEART_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_FORMATION.html The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. 18/21 Gene Ontology BP GO:0060347 8.06843380795229e-05 0.000633060828005637 645 1406.09090909091 1190 7.33520884593523e-06 26 1.73135472308137 1.90559584323018 1 18.9228953303702 645 2325 918 3699 2148 1242 273 26 2533 1190 468 743 M15094 GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. 17/26 Gene Ontology BP GO:0043567 0.00863598016755315 0.0184073365641891 175 1655.18181818182 1190 0.000788187974309039 175 1.59157520652311 1.6579774603573 1 9.43040961135463 175 3873 1313 3473 871 831 329 1124 3546 1482 1190 744 M10763 GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 48/78 Gene Ontology BP GO:0090218 0.0122085323735189 0.0240602715518777 1195 1445.81818181818 1191 0.00111607387730915 180 1.12423191008937 1.23002657057655 1 6.21111583695371 1191 180 817 673 2956 1118 366 2830 1889 1202 2682 745 M11326 GO_DEVELOPMENTAL_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_INDUCTION.html A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). 21/39 Gene Ontology BP GO:0031128 0.0748953471733631 0.104651066185483 3040 1824.72727272727 1191 0.00705214425396442 354 1.46359964358234 -1.57637204395454 -1 4.89451075985516 3036 1051 1191 845 2651 1186 956 2705 354 1457 4640 746 M13647 GO_BILE_ACID_AND_BILE_SALT_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_AND_BILE_SALT_TRANSPORT.html The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/63 Gene Ontology BP GO:0015721 0.00167393730419908 0.00579891218238557 1380 1527.63636363636 1191 0.000152292029910236 550 1.40977215627987 -1.47481557754558 -1 10.7698656718104 1378 999 550 2250 1191 1796 3312 640 2912 1071 705 747 M14442 GO_MITOCHONDRIAL_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FUSION.html Merging of two or more mitochondria within a cell to form a single compartment. 18/23 Gene Ontology BP GO:0008053 0.00169894275303782 0.00583839042088994 1195 1757.54545454545 1191 0.000154568743291211 427 0.659501804535049 -0.681620357199633 -1 5.02590390090514 1194 427 3617 648 485 892 1769 1107 3425 4578 1191 748 M10160 GO_CERAMIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. 11/13 Gene Ontology BP GO:0046514 0.000239834205814743 0.00144552922235233 1650 1299.72727272727 1192 2.18054868602941e-05 62 1.32757958394591 1.62418872322645 1 12.8797615437724 1649 1216 2830 1100 2283 1192 374 62 68 3093 430 749 M12373 GO_GLYCOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 11/13 Gene Ontology BP GO:0019377 0.000347068920556603 0.00188657907400686 1650 1302.36363636364 1193 3.15566987054216e-05 69 1.32757958394591 1.62418872322645 1 12.3548433521688 1650 1217 2831 1101 2284 1193 375 79 69 3096 431 750 M12778 GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT.html The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. 448/630 Gene Ontology BP GO:0061458 3.73112185044818e-07 7.41919229492965e-06 1545 1221 1193 3.39192953021213e-08 133 1.24412399466315 1.22526953735049 1 21.8087599633621 1544 611 178 133 2211 1017 1193 2865 1512 209 1958 751 M11226 GO_MORPHOGENESIS_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIUM.html The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. 472/611 Gene Ontology BP GO:0002009 3.58428037340568e-13 4.38885699406754e-11 785 1141.27272727273 1194 3.2584367030966e-14 26 1.28634679881613 1.2145148451131 1 45.5417787050366 785 1337 26 1194 2691 591 1331 1590 2395 72 542 752 M11449 GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 10/12 Gene Ontology BP GO:0046349 1.17439761400963e-05 0.000145719255946315 2795 1451.54545454545 1195 1.06763989381067e-06 32 1.12599618337585 -1.05929549501279 -1 14.7587293410098 2793 531 2116 324 32 1195 1372 4630 198 1078 1698 753 M11781 GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 13/28 Gene Ontology BP GO:0030656 0.00123544569351967 0.00463217470745125 1195 1929.45454545455 1195 0.000112376365821098 263 1.36886689035363 1.06022471998397 1 10.9136595573467 1195 2873 525 4118 432 1117 263 3038 4302 1020 2341 754 M13874 GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. 21/35 Gene Ontology BP GO:0034142 0.0333092872896919 0.053536481436593 795 1231.54545454545 1195 0.00307496048292102 383 1.14363358103615 1.2254473336918 1 4.96034573656001 792 383 1421 1049 1315 1530 585 2916 1195 1458 903 755 M12414 GO_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 55/110 Gene Ontology BP GO:0051952 0.00505356612515186 0.012713969833998 1445 1195.90909090909 1196 0.000460473819771558 489 1.50562880089119 -1.3991434011802 -1 9.74786392455402 1445 876 689 1788 1057 1717 1600 1196 971 1327 489 756 M15235 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 18/22 Gene Ontology BP GO:0030812 0.000151648034439396 0.00103321580537707 1200 1428.09090909091 1196 1.37871353352299e-05 5 1.01903924317642 -1.14683810768381 -1 10.3920197420687 1196 1755 2813 1423 3576 281 897 664 446 2653 5 757 M15683 GO_CARDIAC_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. 54/69 Gene Ontology BP GO:0060411 0.0151407212084081 0.0284991002357294 1470 1557 1198 0.00138599427489305 158 1.39582165995847 1.36746972704724 1 7.36325511170817 1468 158 861 642 3954 953 1198 4586 656 1282 1369 758 M16953 GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 234/317 Gene Ontology BP GO:0000302 0.00081891399842079 0.00345027790836431 795 1253.81818181818 1198 7.44744531549232e-05 484 1.13501986973914 1.12959722693085 1 9.54387477266158 1198 1382 484 1589 793 1456 1399 795 2687 866 1143 759 M12188 GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 17/21 Gene Ontology BP GO:0010893 0.000384572308366999 0.00201078799663822 3320 1709.81818181818 1200 3.49672318376909e-05 51 1.40748073480286 1.06497804668658 1 12.9658153046235 3316 426 1200 199 265 3764 2316 2385 51 1048 3838 760 M13151 GO_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MORPHOGENESIS.html Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 834/1215 Gene Ontology BP GO:0009887 8.07351227640167e-14 1.17393914444053e-11 630 1504.54545454545 1201 8.07351227640197e-15 11 1.2677868964286 1.28839229642326 1 47.366922293498 628 1889 4411 1704 2133 695 1201 1059 2556 11 263 761 M13655 GO_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_SALVAGE.html Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. 13/17 Gene Ontology BP GO:0043174 0.00132307059865843 0.00488166762980662 2550 1702.90909090909 1201 0.000120351541658308 50 0.704098817891578 -0.704098817891578 -1 5.55359341556433 1018 1201 3430 2550 2723 91 50 262 2550 4551 306 762 M15283 GO_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING.html Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. 58/107 Gene Ontology BP GO:0006342 0.00162274319389554 0.00567061548281701 1200 1579.45454545455 1203 0.000147631034898427 58 1.24501374587877 -1.45363442760879 -1 9.55131691806773 1197 2628 2963 2176 843 436 1890 1203 726 3254 58 763 M15435 GO_CELLULAR_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. 491/767 Gene Ontology BP GO:0055082 9.52873565228319e-11 5.54215087375921e-09 1210 1306.18181818182 1206 8.66248695699624e-12 55 1.22579411977411 1.31445919115857 1 34.5909670162803 1206 1334 55 929 4011 419 1436 1727 2077 83 1091 764 M10483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. 35/50 Gene Ontology BP GO:0048662 0.00117693450839506 0.0044388316373356 2450 1426.36363636364 1207 0.000107051327753439 267 1.50479600891682 1.34013781253199 1 12.0937126247026 2447 267 522 1761 2020 1207 751 3757 805 409 1744 765 M12917 GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. 12/17 Gene Ontology BP GO:0006044 5.67287528483682e-06 7.8094345267295e-05 1895 1382.63636363636 1207 5.15717264804594e-07 19 1.05337392509354 -0.962356383126159 -1 14.7817803928658 1895 1207 2555 989 19 976 2296 2226 291 1958 797 766 M13053 GO_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DIFFERENTIATION.html The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. 75/95 Gene Ontology BP GO:0002062 7.19597210502719e-07 1.31305326292908e-05 415 1309.18181818182 1207 6.54179496250563e-08 196 1.28057387465864 1.38943899764043 1 21.362545246069 411 1498 196 1564 622 1947 1266 1207 3771 788 1131 767 M10341 GO_PINOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PINOCYTOSIS.html An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. 21/23 Gene Ontology BP GO:0006907 0.000448231379855153 0.00225716516284202 3165 1463.90909090909 1208 4.07566117511364e-05 77 1.13795343124927 1.13785340942945 1 10.2855714221947 1986 1055 2425 332 280 959 1208 3164 77 1455 3162 768 M10576 GO_HEART_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 34/39 Gene Ontology BP GO:0061384 0.000277408359188648 0.00161145434690332 275 1408.27272727273 1208 2.52221222810186e-05 16 1.48180798804651 1.5273374256151 1 14.1381951424962 271 3420 1208 3758 2043 74 16 70 3073 1441 117 769 M16902 GO_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a synapse. 90/123 Gene Ontology BP GO:0007416 0.00433451666678322 0.0114010774734552 1210 1560.27272727273 1209 0.000394825483023048 664 1.31271341375667 1.07267310505042 1 8.70995466916985 1209 798 664 986 1141 1035 1847 4148 1710 1875 1750 770 M12071 GO_HOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. 11/13 Gene Ontology BP GO:0050667 0.00203881728831071 0.00659250649236257 1210 1645.36363636364 1210 0.000185519016997961 272 1.55589923860672 -1.55589923860672 -1 11.590979839847 1210 3243 2393 2982 1042 835 1505 272 768 3094 755 771 M13178 GO_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that modulates the frequency, rate or extent of response to wounding. 411/603 Gene Ontology BP GO:1903034 2.01229765083929e-24 4.6816104846776e-21 680 1162.18181818182 1210 1.82936150076298e-25 2 1.43888125132189 1.4193403399431 1 100 678 615 2 29 3204 1210 1476 1582 2306 6 1676 772 M13929 GO_PURINE_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOTIDE_TRANSPORT.html The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. 12/18 Gene Ontology BP GO:0015865 0.000136796862005244 0.000958662374111104 195 1320.54545454545 1210 1.24368517116612e-05 43 0.949409912542312 -0.949409912542312 -1 9.78679774072247 195 1210 2982 1533 3491 62 168 43 1595 3199 48 773 M15294 GO_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_FORMATION.html The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 44/51 Gene Ontology BP GO:0060343 1.61290155993345e-06 2.59682732123541e-05 30 1629.18181818182 1211 1.46627522037508e-07 29 1.52158855513788 1.54913376427156 1 23.8444646119817 29 3064 219 3624 2301 1305 879 1211 3777 581 931 774 M10407 GO_RESPONSE_TO_ORGANOPHOSPHORUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANOPHOSPHORUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. 175/232 Gene Ontology BP GO:0046683 5.38056394747414e-07 1.02605590359005e-05 1810 1542.90909090909 1212 4.89142296673179e-08 185 1.42370540175086 1.26573720991668 1 24.2728307561174 1810 2003 185 1026 631 704 1212 3641 2404 204 3152 775 M11759 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 35/38 Gene Ontology BP GO:1903846 0.00565009430527605 0.0134540021460564 910 1234 1212 0.0005149688550686 701 1.52581568096326 1.48436403798842 1 9.75052685773229 908 962 1368 829 759 1996 1236 2309 1294 1212 701 776 M13331 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. 35/38 Gene Ontology BP GO:0030511 0.00565009430527605 0.0134540021460564 910 1221.18181818182 1213 0.0005149688550686 702 1.52581568096326 1.48436403798842 1 9.75052685773229 909 963 1369 830 760 1997 1237 2158 1295 1213 702 777 M10247 GO_LENS_FIBER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. 28/49 Gene Ontology BP GO:0070306 0.0116905655651417 0.0232960178049697 425 1338.36363636364 1214 0.00106846855519105 217 0.983847297118651 0.980643718568632 1 5.48134799259089 424 1000 2371 1414 3043 217 262 2244 1214 1709 824 778 M11032 GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 14/16 Gene Ontology BP GO:0071545 0.0124190098718111 0.0243924242015775 3870 2187.90909090909 1214 0.00113542493951119 55 0.914817785452048 -1.09751390074285 -1 5.03354228390478 3868 1188 3244 661 969 4635 3463 924 55 3846 1214 779 M12756 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. 10/28 Gene Ontology BP GO:0032693 0.00482298723170755 0.01227645491747 1215 2081.63636363636 1215 0.000439417552051312 272 1.65833983518155 1.45143155429915 1 10.8238666736376 2965 1215 940 1215 726 4484 2395 3278 272 1083 4325 780 M16725 GO_NEGATIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a lower concentration of a chemical. 56/67 Gene Ontology BP GO:0050919 1.07238709088966e-05 0.000134567861304248 1795 1551.54545454545 1218 9.7490210751093e-07 259 1.56845148567577 1.60046804966697 1 20.7477077184266 1792 863 259 781 1175 4124 3769 1222 1218 371 1493 781 M10624 GO_RESPONSE_TO_STEROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 534/831 Gene Ontology BP GO:0048545 1.99918125471715e-09 7.81696670436882e-08 1040 1569.81818181818 1219 1.99918125651567e-10 41 1.28499619874492 1.28328612378192 1 31.2125966646245 1039 600 4252 1219 2985 351 1573 2038 2227 41 943 782 M13421 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. 179/302 Gene Ontology BP GO:0021953 9.03868299210749e-07 1.58108992339384e-05 790 1567.81818181818 1219 8.21698791422323e-08 203 1.26802360299526 1.28965306269125 1 20.8033295366212 789 1999 203 2393 3609 409 380 2491 3400 354 1219 783 M14291 GO_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_CHEMOTAXIS.html The movement of a macrophage in response to an external stimulus. 11/17 Gene Ontology BP GO:0048246 0.00218153290391836 0.0069146271130328 1220 1464.18181818182 1219 0.000198518102963789 99 2.28307366546216 2.40303997780232 1 16.8514730743515 1219 3587 851 2058 4183 207 99 284 1879 1235 504 784 M14282 GO_METANEPHRIC_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. 13/23 Gene Ontology BP GO:0072075 0.00213878885918629 0.00682096268800125 815 1452.81818181818 1220 0.000194624634036957 299 1.25230416767908 1.04792709065685 1 9.26386143051966 811 2356 1220 2598 531 1074 299 1851 2098 2103 1040 785 M15087 GO_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 201/329 Gene Ontology BP GO:0016042 0.00882612339160492 0.0187012532518842 4365 2105.45454545455 1220 0.000805612077739147 259 1.1728981449596 -1.0717640229881 -1 6.91926884746744 4363 687 945 259 878 2657 4493 2901 1220 1197 3560 786 M16599 GO_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 193/278 Gene Ontology BP GO:0030098 0.00874382121507987 0.0185946069989793 1395 1649.72727272727 1220 0.000798069802393925 532 1.16750731633004 1.1153567085402 1 6.89733184829461 1393 706 771 532 3763 1165 1220 2810 1739 842 3206 787 M16017 GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/55 Gene Ontology BP GO:0032892 0.00133019643596038 0.00489069636576909 980 1660.09090909091 1221 0.000121000127310648 124 1.53939447013458 1.77414558939188 1 12.1504304122183 978 2727 1221 3207 2234 1079 918 208 3743 1822 124 788 M12944 GO_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MORPHOGENESIS.html The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. 73/93 Gene Ontology BP GO:0048813 0.0147203082551202 0.0278769207615281 880 1668.27272727273 1222 0.00134724865426604 609 1.31129422090519 1.32410495769292 1 6.95968720265931 877 840 856 609 3983 1177 1222 3973 1485 1513 1816 789 M10690 GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an alpha-amino acid. 69/84 Gene Ontology BP GO:1901607 0.04503306079366 0.068253691163811 505 1531.54545454545 1223 0.00418019833987123 382 1.14503901987646 -1.24250639075391 -1 4.55353306782793 505 838 2729 491 3986 918 1516 1223 382 2406 1853 790 M11207 GO_PROTEASOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ASSEMBLY.html The aggregation, arrangement and bonding together of a mature, active proteasome complex. 15/17 Gene Ontology BP GO:0043248 0.00962055736918444 0.0200443782909052 615 2076.72727272727 1223 0.000878444296258869 340 0.526697446854442 -0.526697446854442 -1 3.0470255606856 613 3551 3815 3355 897 340 1223 909 2653 4465 1023 791 M13466 GO_BASIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASIC_AMINO_ACID_TRANSPORT.html The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/14 Gene Ontology BP GO:0015802 0.000138505853366786 0.000964772059454575 1440 1149.81818181818 1223 1.25922340069994e-05 62 1.26674401119215 -1.60262376204551 -1 13.0495860983755 1437 1223 2115 1741 157 1436 855 373 62 2475 774 792 M16151 GO_AORTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_MORPHOGENESIS.html The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. 44/54 Gene Ontology BP GO:0035909 2.22017195103517e-05 0.00024325498364668 50 1421.72727272727 1224 2.01835850603666e-06 50 1.48298801568149 1.5157158871588 1 18.3129365775526 50 2669 281 2719 1320 708 572 1932 3445 1224 719 793 M13152 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 1392/1994 Gene Ontology BP GO:0051240 3.2803548418292e-12 2.54391517983855e-10 505 1728.63636363636 1225 3.28035484183404e-13 20 1.26339967622393 1.30237446729247 1 41.4327400220325 502 2434 4412 1716 3746 770 1225 659 2487 20 1044 794 M11013 GO_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of a tissue are generated and organized. 599/815 Gene Ontology BP GO:0048729 4.88081884702009e-10 2.20489806749364e-08 825 1466.45454545455 1227 4.88081884809209e-11 36 1.30341610611265 1.26386188557933 1 34.1095798712266 821 1318 4274 700 2451 1066 1596 1227 2114 36 528 795 M13215 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). 418/1835 Gene Ontology BP GO:0007186 1.15585918415393e-24 4.6816104846776e-21 795 1125.72727272727 1227 1.05078107650357e-25 1 1.37935199118839 1.44289304703591 1 95.8623682442857 794 1345 1 1437 2379 110 1227 1818 2317 23 932 796 M14579 GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 155/224 Gene Ontology BP GO:0050731 9.8169903878452e-07 1.69179467683866e-05 285 1359.36363636364 1227 8.92454069859316e-08 205 1.38759662164629 1.56133517190539 1 22.6266278067358 285 2537 205 2128 2596 1227 1067 413 2730 513 1252 797 M11274 GO_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORT.html The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 128/215 Gene Ontology BP GO:0006836 0.00107148364243672 0.00416857306710538 4600 1736.36363636364 1229 9.74550774374983e-05 5 1.28386603427471 -1.54725912371332 -1 10.4363320799982 4600 5 509 289 1165 3998 3887 1233 1229 710 1475 798 M16155 GO_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 421/571 Gene Ontology BP GO:0097305 5.13550578714772e-14 8.23983049227529e-12 845 1224.90909090909 1229 4.66864162467985e-15 21 1.26433358154636 1.28253968421544 1 47.9023863466568 842 616 21 1229 3114 942 1454 1292 2537 75 1352 799 M15871 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. 81/118 Gene Ontology BP GO:1900076 0.0014919674936818 0.00530338025065042 715 1565.36363636364 1230 0.000135725478049854 55 0.962977567633046 1.03524005282212 1 7.48095063484039 715 1503 2214 3138 1230 308 757 591 3758 2950 55 800 M12078 GO_VENTRAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. 35/71 Gene Ontology BP GO:0021517 0.00222950098693054 0.00702360737453472 1025 1583.09090909091 1231 0.000202887599570808 167 1.47712719340264 1.37660602435322 1 10.8646822002116 1021 3411 1231 3224 537 1216 167 1001 2258 1915 1433 801 M12523 GO_L_ASCORBIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 11/12 Gene Ontology BP GO:0019852 0.000159763649753924 0.0010544400883759 4205 1990.09090909091 1231 1.45250229949475e-05 178 1.07866138343571 -1.20742310714625 -1 10.9680946126013 4202 517 1981 731 178 3588 3885 883 201 1231 4494 802 M11001 GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. 19/22 Gene Ontology BP GO:0042219 0.000446780738599318 0.00225474053872302 1235 1499.36363636364 1232 4.06246815999302e-05 98 1.61503404992958 -1.5630687621891 -1 14.6047874183788 1232 3515 2087 790 2243 890 2044 98 998 1733 863 803 M12526 GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. 14/23 Gene Ontology BP GO:0021681 0.00381823010442751 0.0104198651086309 3725 2029 1232 0.000347715728638319 22 1.91919649012977 -1.67141267967556 -1 12.9953963886926 3725 1178 1232 728 3871 2973 2946 380 22 1143 4121 804 M12134 GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 14/26 Gene Ontology BP GO:0071257 0.00148365657126125 0.00528595254676769 4420 2133.45454545455 1233 0.000134968916286292 91 1.22308281712765 -1.19585148515757 -1 9.51045207664657 4417 459 1233 310 461 3494 4450 4413 91 1142 2998 805 M12464 GO_L_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_IMPORT.html The directed movement of L-enantiomer amino acids into a cell or organelle. 10/23 Gene Ontology BP GO:0043092 0.00961441966977884 0.0200443782909052 880 1351.81818181818 1233 0.000877881399927498 398 1.50109932784185 1.25627930069488 1 8.70381627830193 880 1233 1125 2278 3073 1430 398 621 862 1648 1322 806 M14814 GO_FEMALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GAMETE_GENERATION.html Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. 99/155 Gene Ontology BP GO:0007292 0.00178702960755577 0.00604332358214052 565 1460.72727272727 1233 0.000162589349082195 80 1.21443465386839 1.09480063354941 1 9.20167558589263 561 2061 1216 3689 2738 80 171 245 1799 2275 1233 807 M10832 GO_ADULT_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_BEHAVIOR.html Behavior in a fully developed and mature organism. 130/246 Gene Ontology BP GO:0030534 0.00186391423938064 0.00623053065882891 910 1282.18181818182 1237 0.00016959048055118 252 1.29709732028194 1.24700711521119 1 9.76997359095047 910 2550 560 1297 1237 252 672 2602 1886 1537 601 808 M14719 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. 18/27 Gene Ontology BP GO:2000136 0.00536273601677117 0.0132516254307149 1240 2267.27272727273 1237 0.000488713913349883 226 1.03108954695108 1.03108954695108 1 6.60879086108388 1237 4539 3234 4475 748 786 562 976 4557 3600 226 809 M11129 GO_REGULATION_OF_NOREPINEPHRINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOREPINEPHRINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. 10/23 Gene Ontology BP GO:0014061 0.000555942679916451 0.00262619420269162 2010 1198.72727272727 1238 5.0553019730078e-05 228 1.54793904948746 1.55897512104742 1 13.6470910235615 2007 1229 1238 1319 310 1720 520 326 228 2313 1976 810 M11995 GO_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 118/201 Gene Ontology BP GO:0001816 0.000494155936606631 0.00241893716971681 335 1653.72727272727 1239 4.49333606380411e-05 333 1.29173120884702 1.4169401816871 1 11.5441956825313 333 1450 447 3225 3956 1088 1429 790 3279 955 1239 811 M11315 GO_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGENERATION.html The regrowth of a lost or destroyed body part, such as an organ or tissue. 177/245 Gene Ontology BP GO:0031099 0.0207537558874555 0.0365667316827147 1740 1480.63636363636 1240 0.00190474202821094 717 1.18968434101178 1.33923410955137 1 5.83393862023845 1737 717 912 1240 3108 2172 2012 1701 1191 724 773 812 M16698 GO_ASTROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DEVELOPMENT.html The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 22/39 Gene Ontology BP GO:0014002 0.00329967976879022 0.00940772669373829 370 1756.18181818182 1240 0.000300421747738194 342 1.11545207212591 1.24477436257333 1 7.71780183079606 369 4160 2032 3400 1240 830 397 342 3950 2066 532 813 M16900 GO_QUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving quinone. 32/46 Gene Ontology BP GO:1901661 0.0037073020341385 0.0102131890851666 410 1924 1242 0.000337596738681906 359 1.06162986140601 -1.05960753172367 -1 7.2153978960991 406 3104 2944 3487 648 359 1242 1084 3811 3546 533 814 M10510 GO_CORONARY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORONARY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. 68/93 Gene Ontology BP GO:0060976 0.00197938234066234 0.0064722881455389 475 1330 1243 0.000180105952318414 270 1.25923575459626 1.31459043578201 1 9.41330409032107 473 1527 1243 3048 1443 586 705 270 2173 2385 777 815 M16341 GO_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 87/169 Gene Ontology BP GO:0030814 5.14494196167642e-05 0.000463599074866202 1290 1469.09090909091 1243 4.67732935067475e-06 315 1.33315779238171 1.27908029674375 1 15.1850472801086 1286 2085 315 1243 3392 790 1248 1079 3509 869 344 816 M12216 GO_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_DEVELOPMENT.html The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 90/114 Gene Ontology BP GO:0001892 0.00577426225782821 0.0134540021460564 2185 1405.72727272727 1246 0.000526315789473684 54 1.17682751932295 1.27679610136605 1 7.51792454904347 2185 54 1246 154 1154 2151 2313 2022 513 979 2692 817 M15516 GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION.html Any process that modulates the frequency, rate or extent of interferon-gamma secretion. 8/15 Gene Ontology BP GO:1902713 0.000536525824445114 0.00254480597466169 1345 1625.72727272727 1246 5.36655405461002e-05 24 1.03828691118294 1.08249733506365 1 9.19886964370089 1343 1246 4562 614 1104 492 24 2290 3340 2023 845 818 M10513 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 108/192 Gene Ontology BP GO:1903555 0.0199613741949016 0.0354972463265076 570 1672.54545454545 1247 0.00183134776047345 567 1.19246677515388 1.36647087119503 1 5.90016630003382 567 2566 906 2513 3385 1005 1247 1438 2507 1120 1144 819 M10505 GO_COLLAGEN_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_FIBRIL_ORGANIZATION.html Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. 54/60 Gene Ontology BP GO:0030199 2.39379943492021e-07 5.06288580485625e-06 20 1462.36363636364 1251 2.17618154126121e-08 20 1.44057265990589 1.51915044541769 1 26.0714586512798 20 2140 168 2586 1200 1578 1812 1246 3750 335 1251 820 M14896 GO_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_DEVELOPMENT.html The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. 352/528 Gene Ontology BP GO:0001654 6.3094424149111e-07 1.17902954042495e-05 815 1263.45454545455 1251 5.73585838583156e-08 190 1.21484485894333 1.21275706441716 1 20.4597133924817 813 2476 190 1272 2066 321 1251 2580 2302 215 412 821 M11867 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT.html The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+. 23/52 Gene Ontology BP GO:0072488 0.000157461137711176 0.00104666667681443 1805 1013.72727272727 1252 1.43156735313712e-05 174 1.02198073962601 0.951858923787192 1 10.4024198938623 1801 336 1596 314 174 1259 609 231 1252 1674 1905 822 M12738 GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. 3/14 Gene Ontology BP GO:0007210 0.00202381238138034 0.00656680544669646 2470 1784.45454545455 1252 0.000202565786471368 133 1.5442804018578 -1.47426023309742 -1 11.5133001492098 2468 1252 4384 518 1220 4344 2685 286 133 1670 669 823 M15877 GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the inflammatory response. 97/167 Gene Ontology BP GO:0050729 2.29566593019027e-08 6.76059086909831e-07 395 1168.09090909091 1253 2.0869690492229e-09 118 1.50865094530642 1.58999838935505 1 31.8142653008372 391 1467 118 1203 2206 1253 1451 609 2377 156 1618 824 M12562 GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 10/20 Gene Ontology BP GO:0045076 0.00559413408167096 0.0134540021460564 2175 1789.18181818182 1255 0.000509855420489848 757 1.82866227800659 -1.8977057546865 -1 11.6879450456718 2175 2392 1255 1501 757 3473 4326 956 935 1081 830 825 M15988 GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 77/141 Gene Ontology BP GO:0030801 3.44688070052387e-05 0.000335904000263133 930 1378.90909090909 1256 3.13357700562987e-06 299 1.3126108835462 1.16555743199589 1 15.578806572305 928 2103 299 1256 2091 809 1275 901 3292 835 1379 826 M16379 GO_SUBPALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBPALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. 27/44 Gene Ontology BP GO:0021544 0.00132354338935874 0.00488166762980662 1455 1298.63636363636 1256 0.000120394574402844 207 1.50006890702816 -1.25266898428118 -1 11.8438773258368 1451 1661 963 1472 4086 238 1960 207 741 1256 250 827 M11579 GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of activated T cell proliferation. 28/43 Gene Ontology BP GO:0046006 0.013993457460518 0.0267476357641187 1260 1591.72727272727 1257 0.00128029689843775 493 1.34465701668962 -1.26148413757494 -1 7.21959631259676 1257 1016 1848 1038 2913 1073 1964 749 2990 2168 493 828 M13002 GO_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. 264/391 Gene Ontology BP GO:0046883 4.04087580849509e-05 0.000380146911810331 540 1622.36363636364 1258 3.67359093787653e-06 304 1.23460063643256 1.18760410782276 1 14.4254804995198 536 1952 304 2521 4391 917 1020 1965 2623 359 1258 829 M15189 GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. 123/198 Gene Ontology BP GO:0002761 0.00140393736123966 0.00508367357342269 205 1794.45454545455 1258 0.000127712189983377 204 1.32300402992645 1.34183683309942 1 10.3649406625167 204 3659 835 4159 2875 1428 1258 215 3189 963 954 830 M12198 GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 30/38 Gene Ontology BP GO:0044275 0.00017715859717327 0.00114171600089643 185 1549.81818181818 1260 1.61066240697719e-05 184 0.962113945098096 1.01597775294216 1 9.66825557319253 1260 982 2708 1221 184 3045 2400 1242 184 1904 1918 831 M12069 GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 121/221 Gene Ontology BP GO:0002263 0.0185850228035697 0.0335258065739958 1375 1597.27272727273 1261 0.00170399149976142 737 1.20295274838535 1.10260507422945 1 6.05420495283698 1371 757 894 1261 3344 1491 1233 2534 737 782 3166 832 M15731 GO_PHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 27/34 Gene Ontology BP GO:0009395 0.0018823858790584 0.00628317180434631 1030 1355.81818181818 1261 0.00017127258516084 261 1.16523236324242 1.20607871210423 1 8.76110204704501 1028 322 1690 1226 1978 1984 1261 261 2322 2078 764 833 M13817 GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. 15/19 Gene Ontology BP GO:1900745 0.00433940232009703 0.01140564680554 3045 2021.27272727273 1264 0.000395271391751515 539 1.45172808512826 1.68954249590642 1 9.63259315995867 3043 1138 1170 539 690 4173 3799 3962 709 1264 1747 834 M10670 GO_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_PRIMARY_GERM_LAYER.html The formation of the ectoderm, mesoderm and endoderm during gastrulation. 128/178 Gene Ontology BP GO:0001704 1.06855787012803e-05 0.000134567861304248 280 1628.36363636364 1266 9.71420963850633e-07 258 1.34804564989586 1.39712293960665 1 17.830648420542 280 3312 258 2928 2574 1138 1575 1266 3266 459 856 835 M15140 GO_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHRONIC_INFLAMMATORY_RESPONSE.html Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. 15/23 Gene Ontology BP GO:0002544 0.00722095308076272 0.0160522044394682 220 1982.36363636364 1266 0.000658614868085652 219 1.38974664430033 1.45947937170295 1 8.51568655334226 219 3909 1108 4522 2504 1225 1572 544 4337 1266 600 836 M13755 GO_ENDODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. 82/113 Gene Ontology BP GO:0007492 0.000256120194249581 0.00150470614121629 190 1571.27272727273 1267 2.32863651072904e-05 188 1.38955360197151 1.42601382695072 1 13.3987298139583 188 2597 410 2201 2821 1139 887 1267 3450 852 1472 837 M15427 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 23/30 Gene Ontology BP GO:0071354 0.0154651444706578 0.028992472692172 1040 1373.27272727273 1268 0.00141590368243134 381 0.983852284964987 0.969568877655341 1 5.16180861310686 381 1040 2240 1312 1037 715 733 1268 2830 1683 1867 838 M15712 GO_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that modulates the frequency, rate, or extent of receptor recycling. 23/26 Gene Ontology BP GO:0001919 0.000777297324829464 0.0033386524265847 1270 1216.90909090909 1270 7.068837209853e-05 29 1.12538727169271 -1.22080330423752 -1 9.51774340428274 1270 1058 2657 392 1382 314 1673 307 1694 2610 29 839 M11285 GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. 23/27 Gene Ontology BP GO:0007176 9.04071097932788e-05 0.000691153061986786 1450 1199.27272727273 1271 8.2191659281396e-06 134 1.32455440318403 -1.38499794205733 -1 14.3015838820984 1450 2267 2046 1011 134 1471 1409 1004 449 1271 680 840 M14935 GO_GLIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. 8/16 Gene Ontology BP GO:0021781 0.00198144651748238 0.00647448781309377 650 1620.54545454545 1271 0.000198321549644198 74 1.77604930137843 1.77604930137843 1 13.280177548983 650 2420 4526 1677 3405 418 74 637 727 2021 1271 841 M12305 GO_HEMIDESMOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMIDESMOSOME_ASSEMBLY.html Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. 23/25 Gene Ontology BP GO:0031581 0.0041528104898532 0.0110733680282447 205 1718.63636363636 1272 0.000378242753151442 129 1.83120690111505 -1.8162169162685 -1 12.2337107803156 201 2770 758 1992 4221 149 129 2841 3974 1272 598 842 M11083 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. 15/46 Gene Ontology BP GO:0002719 0.0013494767074209 0.0049441851335665 2170 1579.09090909091 1274 0.000122755016905765 389 1.35920571643725 1.53117833721185 1 10.7050008878836 2167 483 1274 1296 439 4406 3212 915 802 389 1987 843 M14423 GO_I_KAPPAB_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_PHOSPHORYLATION.html The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 32/54 Gene Ontology BP GO:0007252 0.000936655558362847 0.00378649723115754 945 1914.18181818182 1274 8.51867799719675e-05 171 1.00101335512345 1.08817132493245 1 8.27760578662713 942 3107 2665 3410 1274 763 254 171 3868 3545 1057 844 M13978 GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 78/103 Gene Ontology BP GO:0061178 0.0285832114770773 0.0474959513292895 400 1403.36363636364 1275 0.00263286123505675 398 1.20407001753119 1.20907556816176 1 5.43708159920278 398 819 1209 1357 4464 1320 467 1066 1275 1297 1765 845 M14014 GO_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYSTEM_PROCESS.html A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. 1143/2821 Gene Ontology BP GO:0003008 4.93879841125052e-17 1.64144492911062e-14 825 1663.90909090909 1276 4.93879841125052e-18 5 1.26665661450008 1.25798994288287 1 59.6861236321473 822 1276 4465 685 3103 1119 1474 1787 2383 5 1184 846 M14503 GO_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 487/735 Gene Ontology BP GO:0042493 4.36517997737675e-08 1.21623846914575e-06 720 1536.36363636364 1276 3.96834551271768e-09 123 1.22714847149331 1.2312130104097 1 24.8059727093688 719 1918 123 3702 2613 200 781 2125 2758 685 1276 847 M15119 GO_OSTEOBLAST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DEVELOPMENT.html The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. 24/31 Gene Ontology BP GO:0002076 0.00971584561593128 0.0201460916447987 2595 1601.36363636364 1278 0.00088718371113932 195 1.77243841821313 -1.58023315205748 -1 10.2657267831711 2595 2253 787 899 3395 1278 2804 1657 195 723 1029 848 M15696 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. 25/30 Gene Ontology BP GO:0015012 0.00577426225782821 0.0134540021460564 1100 1197.72727272727 1278 0.000526315789473684 84 1.28804595390505 -1.28791613734484 -1 8.22942872342482 1096 331 1569 84 1897 2155 1278 723 417 1884 1741 849 M12619 GO_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYMERIZATION.html The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. 74/96 Gene Ontology BP GO:0051258 0.00186393696047493 0.00623053065882891 605 1451.45454545455 1279 0.00016959254961148 86 1.38930603440212 -1.43625016765966 -1 10.4652644414824 603 4016 2552 2569 2595 107 578 258 1279 1323 86 850 M10152 GO_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of neurological system. 684/2079 Gene Ontology BP GO:0050877 3.04542004434133e-08 8.74712312735816e-07 1005 1673.72727272727 1280 3.04542008607695e-09 64 1.29113186634257 1.28042836201892 1 26.7318337071302 1001 1311 4229 1177 3149 1183 1930 1280 2286 64 801 851 M14441 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION.html The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. 23/26 Gene Ontology BP GO:0015949 0.021867298401228 0.0380652972169524 1045 1639.72727272727 1280 0.00200797508305123 594 0.896111720715385 -1.02928238145629 -1 4.3382533707251 1043 1700 3079 1512 3553 1045 594 902 721 2608 1280 852 M11864 GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE.html The movement of organelles or other particles from one location in the cell to another along microtubules. 117/133 Gene Ontology BP GO:0010970 0.0076285662130695 0.0166881610669546 1055 1674.09090909091 1281 0.00069592251149569 130 0.969698460432323 -1.01213424580263 -1 5.8826717660834 1052 2559 3821 2130 1867 130 926 682 1281 3782 185 853 M12066 GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE.html Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. 13/16 Gene Ontology BP GO:0010889 0.00233432199041419 0.00725073446021176 550 1490.81818181818 1281 0.000212436592821844 78 0.896931044018102 0.925427639220782 1 6.55060433028948 548 1819 2804 3214 1120 999 173 1281 1667 2696 78 854 M11108 GO_NEGATIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LOCOMOTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. 318/444 Gene Ontology BP GO:0040013 2.89396005443023e-09 1.09360499368976e-07 590 1291.90909090909 1283 2.6308727802155e-10 91 1.31524594208425 1.43362498123756 1 31.2918878051589 587 1939 91 1283 2336 2198 1915 852 1686 137 1187 855 M12324 GO_ANATOMICAL_STRUCTURE_REGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_REGRESSION.html The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. 15/20 Gene Ontology BP GO:0060033 0.0384212483753506 0.0603354939893711 2865 1637.36363636364 1283 0.00355537484685439 369 1.5874350314355 -1.3549889412211 -1 6.60760342734944 2865 1778 1384 670 4219 1283 2359 1143 369 1262 679 856 M13775 GO_VOCALIZATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOCALIZATION_BEHAVIOR.html The behavior in which an organism produces sounds by a mechanism involving its respiratory system. 19/36 Gene Ontology BP GO:0071625 0.000685521379808859 0.00304945600406369 1985 1289.09090909091 1284 6.23395529029247e-05 140 1.67704664951723 -1.96988233771686 -1 14.4141376159726 1984 2300 580 147 1602 1065 3149 140 1756 1284 173 857 M14845 GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 57/107 Gene Ontology BP GO:0042108 0.0242188625193423 0.0415065809585634 355 1778.27272727273 1284 0.00222633277310042 355 1.16556560566937 1.18744525828233 1 5.49615150553904 355 3356 941 3778 1212 1284 928 1061 3662 1427 1557 858 M15093 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. 14/16 Gene Ontology BP GO:0010667 0.000651941425404255 0.0029508593895 1985 1440 1284 5.92849727242623e-05 19 1.4058172313875 1.49342474469067 1 12.1498150275253 1983 1161 1263 993 2733 2415 1284 543 1809 1637 19 859 M16375 GO_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_MATURATION.html Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 22/23 Gene Ontology BP GO:0090128 0.00577426225782821 0.0134540021460564 3235 1644.45454545455 1284 0.000526315789473684 152 1.74319454324498 -1.95265698830558 -1 11.1411773242388 3231 365 1284 152 2349 2108 1050 2034 345 1196 3975 860 M16852 GO_ORGANELLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FUSION.html The creation of a single organelle from two or more organelles. 120/149 Gene Ontology BP GO:0048284 0.0160111340809404 0.029783882291403 1285 1562.81818181818 1284 0.00146626009026489 261 0.998856547352392 -1.030542229977 -1 5.20074905379383 1284 761 3597 552 2552 261 1821 1494 695 3691 483 861 M12479 GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. 41/76 Gene Ontology BP GO:0032651 0.0112282510629841 0.0226267008211628 1285 1395.81818181818 1285 0.00102599728138283 616 1.26936262726937 1.43148069199697 1 7.13009029166484 1285 935 1239 1086 936 1723 1525 2216 1637 616 2156 862 M15245 GO_LINOLEIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LINOLEIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 19/30 Gene Ontology BP GO:0043651 0.0285983722325633 0.0474959513292895 2365 1567.45454545455 1285 0.00263427631406747 481 1.44616310694972 1.49961156208285 1 6.53241761572739 2364 1739 972 1232 4388 1199 481 1418 1560 1285 604 863 M14620 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 77/87 Gene Ontology BP GO:0071230 0.0232385790898309 0.0400478179648085 125 1396.18181818182 1286 0.00213524913694836 122 1.21142183581407 1.1216992144841 1 5.77715869901147 122 830 944 1936 1177 1286 1445 2162 2908 1448 1100 864 M13858 GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. 57/69 Gene Ontology BP GO:0006687 0.0230367616524481 0.039773674199941 2800 1865.72727272727 1287 0.0021165074619982 139 1.3373911081469 1.57978382859606 1 6.39264361586086 2796 139 934 466 3907 3899 3077 1287 346 766 2906 865 M10829 GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an alpha-amino acid. 200/255 Gene Ontology BP GO:1901605 0.0436532104177022 0.0667525763754456 865 1233.36363636364 1288 0.00404947694777759 467 1.2366759594471 -1.27873223821111 -1 4.95963928053848 862 696 1947 467 1918 524 1581 1288 1130 1757 1397 866 M11627 GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. 29/44 Gene Ontology BP GO:0045746 0.000504011286885482 0.00244033768769839 1290 1272.54545454545 1290 4.58297082657264e-05 159 1.46535160966965 1.43596747208047 1 13.0781087533623 1290 1657 448 1972 356 1794 1761 159 2364 1070 1127 867 M13300 GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 953/1400 Gene Ontology BP GO:0014070 5.06941729929936e-13 5.89699967340998e-11 855 1662.09090909091 1290 5.06941729930052e-14 14 1.27008636365192 1.28854062031144 1 44.4089236967995 854 1290 4420 1191 2987 367 1187 2355 2244 14 1374 868 M10121 GO_HEMOGLOBIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. 11/15 Gene Ontology BP GO:0020027 0.000118894890477093 0.000859034045636512 3540 1953.45454545455 1292 1.0809210583232e-05 126 1.07342001882153 -1.22574915085487 -1 11.2414166625775 3537 1209 2121 1292 148 4017 4578 126 525 1227 2708 869 M12397 GO_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 53/76 Gene Ontology BP GO:0090183 0.00279751408478143 0.00830939453536508 1415 1509.81818181818 1292 0.000254643431085208 570 1.32699375280006 1.31354508098794 1 9.4280883298126 1413 1562 614 1078 3751 946 1059 2851 1292 1472 570 870 M11606 GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 493/649 Gene Ontology BP GO:0051962 1.21966589672091e-07 2.82343553106586e-06 1295 1542.54545454545 1294 1.10878724030765e-08 152 1.24241187403008 1.27748882561899 1 23.5609946171548 1294 1916 152 1202 3997 1019 1809 2562 1939 276 802 871 M13469 GO_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 45/70 Gene Ontology BP GO:0048708 0.0215551524481059 0.0376063458346595 660 1378.90909090909 1294 0.0019790262323385 657 1.06125800116434 1.25957666420137 1 5.15883876392474 657 911 1600 1149 2360 1315 1470 895 2472 1294 1045 872 M15420 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. 13/16 Gene Ontology BP GO:1903203 2.23889087357288e-05 0.000243970942265447 670 1404.27272727273 1294 2.03537605326362e-06 58 1.08737497070712 1.17548954977905 1 13.42005022549 667 2357 2623 1913 58 1294 1174 771 1401 2104 1085 873 M12888 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 19/21 Gene Ontology BP GO:0060211 3.62386753664476e-05 0.000345529828852624 530 1548.09090909091 1295 3.29447930074638e-06 83 0.755315589238951 0.7733802178577 1 8.92829769315132 529 1743 3433 2390 83 144 312 1295 2846 4025 229 874 M15622 GO_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEEDING_BEHAVIOR.html Behavior associated with the intake of food. 58/131 Gene Ontology BP GO:0007631 0.00245268300822838 0.00749332504089735 2770 1673.90909090909 1297 0.000223220151985289 130 1.4373173380702 -1.34550895219182 -1 10.4334251968157 2766 130 603 495 1297 2887 2302 3847 571 1249 2266 875 M11194 GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. 59/79 Gene Ontology BP GO:0002792 0.0214631079376811 0.0375443012158008 1135 1805.72727272727 1298 0.00197049149903238 349 1.23148775826233 1.24634530690794 1 5.9910654752456 1135 1548 1252 3023 2866 349 400 3799 3199 1298 994 876 M15826 GO_STEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 122/191 Gene Ontology BP GO:0016125 0.00165727858774228 0.00575471437967524 2930 1815.90909090909 1298 0.000150775304358215 7 1.21288264187602 -1.13842069639356 -1 9.27803020823768 3520 7 781 58 477 2449 4259 2927 1298 1269 2930 877 M13078 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of multicellular organismal development. 1657/2329 Gene Ontology BP GO:2000026 6.44082097659468e-13 6.96956744281281e-11 905 1667.18181818182 1299 6.44082097659654e-14 16 1.22453262312439 1.26008689231395 1 42.511899783204 903 1257 4405 684 2765 1299 1669 1803 2289 16 1249 878 M14223 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. 13/28 Gene Ontology BP GO:0032695 0.00556731665278092 0.0134540021460564 240 2049.27272727273 1299 0.000507405037508416 237 1.06817208535344 1.06817208535344 1 6.82281680787624 237 4561 2697 4395 1299 828 1083 468 4479 2102 393 879 M11076 GO_MACROMOLECULE_DEACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_DEACYLATION.html The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. 66/70 Gene Ontology BP GO:0098732 0.0149871656481499 0.0282557867750574 1505 1919.81818181818 1300 0.0013718407192481 247 0.867631348340869 -0.90526955478888 -1 4.58395045962641 1503 2608 3964 3791 1184 247 758 1106 1300 4046 611 880 M13996 GO_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 27/41 Gene Ontology BP GO:0071887 0.00346418691183327 0.0097512774959227 1505 1225.54545454545 1300 0.000315423071029722 100 0.9150263264727 -1.07421912537509 -1 6.28041123739714 1505 270 1865 102 2428 1189 1300 1425 361 2936 100 881 M15736 GO_HEXOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 174/228 Gene Ontology BP GO:0019318 0.000496854204632455 0.00242416458005779 2820 1619.45454545455 1300 4.51787682799073e-05 34 1.01559541909327 -0.897160474059654 -1 9.07083674997688 2818 708 1633 34 292 454 2233 4624 809 1300 2909 882 M14038 GO_RESPONSE_TO_NICOTINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NICOTINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. 44/72 Gene Ontology BP GO:0035094 0.00423763534480039 0.011203248442816 720 1907.09090909091 1301 0.000385983631708192 337 1.17493111019129 1.10284151628209 1 7.82517646864856 720 4058 1107 4533 1962 1301 579 398 4116 1867 337 883 M15939 GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS.html The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. 12/15 Gene Ontology BP GO:0003222 0.00161260424750462 0.00564593496135365 555 1129.45454545455 1301 0.00014670795490642 57 1.50210478492904 1.50210478492904 1 11.5355612412509 552 1834 2103 1678 1517 416 57 810 191 1965 1301 884 M16537 GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. 200/257 Gene Ontology BP GO:0014074 7.67965349581867e-06 0.000102682263551851 1510 1521.90909090909 1301 6.98152754882939e-07 251 1.30500467841089 1.20295652776375 1 17.7850169107454 1508 1978 251 1301 947 981 1282 3326 2371 330 2466 885 M10503 GO_MYELOID_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MIGRATION.html The movement of a myeloid leukocyte within or between different tissues and organs of the body. 85/150 Gene Ontology BP GO:0097529 1.4229953772863e-08 4.35605098060077e-07 750 1514.54545454545 1302 1.29363216953678e-09 112 1.54599775188631 1.44815399607441 1 33.6110880021595 750 1490 112 1976 3669 977 1021 1302 2984 147 2232 886 M12737 GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS.html Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. 31/57 Gene Ontology BP GO:0036473 0.0195220293844613 0.0348802461086161 1035 1638.36363636364 1302 0.00179067673996166 453 0.948195984846323 1.12702198280617 1 4.71404980747948 1034 1648 2853 1133 2720 1302 1127 855 1719 3178 453 887 M14500 GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. 67/83 Gene Ontology BP GO:1901292 0.00552357753790101 0.0134540021460564 2625 1380.90909090909 1302 0.000503408601955583 81 1.5006433448817 -1.31190293145082 -1 9.58949040484337 2623 1520 1302 81 754 1062 1369 2610 445 531 2893 888 M12810 GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION.html Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 19/20 Gene Ontology BP GO:0090129 0.00577426225782821 0.0134540021460564 3825 1585.36363636364 1303 0.000526315789473684 162 1.7656102605169 -1.95265698830558 -1 11.2845786989358 3821 419 1426 162 1198 2526 1712 1303 289 1283 3300 889 M16434 GO_PROTEIN_O_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. 88/116 Gene Ontology BP GO:0006493 0.000948896254983463 0.00381608839622995 1395 1469.45454545455 1303 8.63005251712648e-05 367 1.38472801824697 1.3812852182221 1 11.4387107291554 1395 806 499 1176 780 3312 2189 2063 1303 367 2274 890 M16772 GO_MALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DIFFERENTIATION.html The establishment of the sex of a male organism by physical differentiation. 163/273 Gene Ontology BP GO:0046661 0.0075401770152746 0.0165463884340949 1550 1465.27272727273 1303 0.000687831322785793 814 1.23138466837018 1.18665696650355 1 7.48866688693776 1547 1413 1117 814 829 2406 1303 2490 994 1286 1919 891 M14090 GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. 11/18 Gene Ontology BP GO:0070296 9.37806141274752e-05 0.000710614852326551 840 1287.45454545455 1304 8.52587381855077e-06 25 0.919782157638093 -0.919782157638093 -1 9.88996138102242 838 2379 2457 1304 1474 109 611 31 1833 3101 25 892 M12691 GO_SPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 125/149 Gene Ontology BP GO:0006665 0.00111367482438979 0.0042684752536126 4055 1945.09090909091 1306 0.00010129445309784 3 1.20999236698918 -1.07390230057801 -1 9.79266240512079 4055 3 1153 27 1306 2327 4613 4548 297 350 2717 893 M12875 GO_ENDOCRINE_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. 28/51 Gene Ontology BP GO:0031018 0.000403706574673254 0.00208716299106072 1310 1522.09090909091 1307 3.67073340975983e-05 271 0.976428267068384 1.04524868263805 1 8.93761467664224 1307 291 2272 432 271 2601 683 2390 1102 2978 2416 894 M13030 GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 8/21 Gene Ontology BP GO:0042423 0.000501399927991334 0.002430222775983 580 2139.45454545455 1307 5.01513094778977e-05 117 1.51928016997599 1.51928016997599 1 13.5691776462331 578 3944 4402 3603 3583 755 428 117 4071 1307 746 895 M15900 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein. 15/20 Gene Ontology BP GO:0042510 0.00426367319331597 0.0112592913555614 3275 1881.63636363636 1307 0.000388359893046079 686 1.25753899688293 -1.16678731190914 -1 8.3667868700614 3275 1166 1836 1122 686 1307 1751 4397 997 1267 2894 896 M13427 GO_ENDOTHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 113/132 Gene Ontology BP GO:0003158 0.00390214326262325 0.010593157876888 985 1368.81818181818 1308 0.000355371066866478 27 1.26054891570538 1.29817987385702 1 8.50098467029983 982 27 649 782 2854 1977 1550 1308 2257 812 1859 897 M14022 GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that increases the extent to which blood vessels can be pervaded by fluid. 8/13 Gene Ontology BP GO:0043117 0.000439074083050353 0.00222550295036307 950 1737.09090909091 1308 4.39160860905216e-05 104 1.1644010263463 -1.1644010263463 -1 10.5492942429195 947 2418 4466 2051 3453 414 104 106 3585 1308 256 898 M10101 GO_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 723/1049 Gene Ontology BP GO:0048666 0.00273596573850116 0.00816577843569334 855 1678.27272727273 1309 0.000273934006576576 421 1.21836369845197 1.26726987907564 1 8.68695592779429 852 1309 4223 1201 3023 1241 1073 1770 1868 421 1480 899 M11036 GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 59/90 Gene Ontology BP GO:0051965 7.02202129376629e-07 1.28635689290923e-05 1310 1371.81818181818 1309 6.38365775915965e-08 195 1.70667743445173 1.45992793675422 1 28.5264103524609 1309 1541 195 725 1800 1058 1352 3262 610 450 2788 900 M13181 GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 20/22 Gene Ontology BP GO:0071243 0.00578624337307244 0.0134684294221641 675 1789.72727272727 1310 0.000527410736986665 376 0.80062554223992 0.854881073630013 1 5.10995160447716 671 2797 3355 2156 1248 1310 376 482 3044 3694 554 901 M16878 GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. 8/21 Gene Ontology BP GO:0009713 0.000498293308562404 0.00242655386270251 580 2162.90909090909 1310 4.98405077136197e-05 116 1.51928016997599 1.51928016997599 1 13.5725859162319 579 3945 4650 3604 3584 756 429 116 4072 1310 747 902 M13253 GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT.html The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. 128/205 Gene Ontology BP GO:0060538 0.000593941421678586 0.0027525990389148 1115 1633.36363636364 1312 5.40092573345227e-05 383 1.2424758281699 1.30647315047794 1 10.86520545088 1111 753 460 1207 4352 2288 1910 2717 1474 383 1312 903 M10496 GO_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. 667/931 Gene Ontology BP GO:0043408 3.33297232115036e-05 0.000332083944546309 1150 1759.09090909091 1314 3.33302231137582e-06 185 1.173197664707 1.20847747431828 1 13.9429636647107 1146 1314 4246 732 3475 895 1115 1870 2539 185 1833 904 M11769 GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. 300/373 Gene Ontology BP GO:0006520 0.0502958988789473 0.0749845618339449 740 1465.45454545455 1314 0.00468035967600726 575 1.1273804318335 -1.12039599003801 -1 4.32570690717224 738 651 2797 933 1735 575 1696 1314 936 3132 1613 905 M14013 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of organic acid across a membrane. 80/133 Gene Ontology BP GO:1903825 0.000118361915211107 0.00085677245781642 3035 1886.09090909091 1314 1.07607530604427e-05 65 1.19892618305237 1.18078176801744 1 12.5617225920966 3032 65 360 251 1314 4449 3667 2231 597 307 4474 906 M15911 GO_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. 339/435 Gene Ontology BP GO:0001525 4.2556251356653e-17 1.52318644278851e-14 750 1531.90909090909 1314 3.86875012333209e-18 9 1.36003152757123 1.39247212466344 1 64.2378253415876 746 2478 9 2745 2884 1503 1314 1129 2804 103 1136 907 M10468 GO_CELLULAR_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 56/70 Gene Ontology BP GO:0006073 0.00206948471875561 0.00666209563659403 655 1340.81818181818 1315 0.000188312181691487 521 0.959380527850022 0.961004099279622 1 7.12804933928497 651 860 3100 788 521 1600 1358 1315 732 2285 1539 908 M15167 GO_EMBRYONIC_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_EYE_MORPHOGENESIS.html The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. 39/53 Gene Ontology BP GO:0048048 0.000572449209162206 0.00267968427588706 1295 1632.81818181818 1315 5.20543833751829e-05 312 1.34012609702986 1.30673655511642 1 11.773396704263 1291 1594 1046 1263 312 1637 1309 4273 1315 1864 2057 909 M15176 GO_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. 658/940 Gene Ontology BP GO:0030155 1.93551157072788e-13 2.50164870516578e-11 870 1735.81818181818 1316 1.93551157072805e-14 13 1.3073997055554 1.31868020496928 1 47.3785319485011 870 1316 4540 1189 3003 1029 1905 885 2773 13 1571 910 M16457 GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. 29/43 Gene Ontology BP GO:0007212 0.013625845025804 0.0262204536414665 775 1905.54545454545 1316 0.00124645242656703 287 1.03533423467951 1.15237633078824 1 5.58696078287366 772 3113 2485 3926 1316 931 287 1161 3231 2638 1101 911 M10301 GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 362/507 Gene Ontology BP GO:0010721 6.6366968471115e-08 1.725170415062e-06 1005 1176.27272727273 1317 6.03336095210858e-09 133 1.29187796459424 1.39673601150491 1 25.4444595118693 1002 1934 133 1404 2322 851 1469 1317 2007 242 258 912 M12867 GO_OVULATION_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE_PROCESS.html A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 86/121 Gene Ontology BP GO:0022602 0.00409992198259168 0.0109890190005755 1320 1982.63636363636 1317 0.000373416599564842 489 1.43786537591282 1.34422315291607 1 9.6199558854512 1317 3679 655 3571 3840 1268 936 840 3017 489 2197 913 M15711 GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. 16/18 Gene Ontology BP GO:0060055 0.000532778888354941 0.0025347854473574 735 1739.18181818182 1317 4.84461778512398e-05 112 1.32134084191504 1.46798669224668 1 11.7172790046791 734 3880 2285 4506 1686 488 274 112 842 3007 1317 914 M15961 GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS.html The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 21/32 Gene Ontology BP GO:0021692 0.0074433284745304 0.0163858585850115 1260 1623.72727272727 1317 0.000678966513954225 416 1.17783257232795 1.20401802989368 1 7.17957620309507 1259 416 1929 2365 1317 1084 883 553 4007 1946 2102 915 M15990 GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. 111/167 Gene Ontology BP GO:0072593 8.4715724623421e-08 2.11925949824074e-06 285 1581.63636363636 1317 7.70142980778017e-09 22 1.34500675107492 -1.24780307313772 -1 26.0804209751147 3400 22 140 281 2822 1187 2595 2595 1317 284 2755 916 M14273 GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 234/288 Gene Ontology BP GO:0010810 1.13248740831553e-07 2.67485477710262e-06 655 1304.54545454545 1318 1.02953406055659e-08 141 1.30981750336603 1.36445513177335 1 24.9449854377717 653 1962 149 1318 2200 1243 1511 1593 2936 141 644 917 M14844 GO_STEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 11/19 Gene Ontology BP GO:0016127 0.0460748264073338 0.0696285051228724 1225 2161.63636363636 1318 0.00427900476799364 628 1.24950067142426 1.13106235580798 1 4.93292433504218 1222 3583 1318 3694 3601 1276 628 1293 4287 1236 1640 918 M11644 GO_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 286/425 Gene Ontology BP GO:0002521 0.000187732328690988 0.00119660071972489 1320 1668.18181818182 1319 1.70680318495197e-05 387 1.16677035187657 1.15668514607745 1 11.645767127599 1319 656 387 507 3908 1070 1380 3086 2443 707 2887 919 M13154 GO_CELLULAR_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 47/64 Gene Ontology BP GO:0071320 0.00659795729301566 0.0148958249803017 170 1477.18181818182 1319 0.000601620774747429 108 1.33192570604757 1.25352782994451 1 8.30880646086662 168 2649 1793 2344 3913 108 297 1319 1431 1130 1097 920 M13973 GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 35/45 Gene Ontology BP GO:0061036 0.00261197943377557 0.00787146392834051 1250 1267.72727272727 1319 0.000237735064152699 410 1.49922237376614 1.52138721172632 1 10.7736568421592 1248 1624 802 1305 1807 1454 1653 1822 501 410 1319 921 M10259 GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING.html The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. 589/794 Gene Ontology BP GO:0009792 0.0972847071986068 0.13079044859726 1125 1739.18181818182 1320 0.0101826091602028 899 1.1287246425296 1.13591580489048 1 3.39851467922995 1121 1320 4233 1306 2509 899 1588 2167 1728 1201 1059 922 M10333 GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. 41/51 Gene Ontology BP GO:0031109 0.00807883614467662 0.0174597420256295 1070 1671.18181818182 1320 0.000737150605022333 54 1.28561398321637 -1.41899158133243 -1 7.71636607092568 1070 4393 3145 1320 2602 924 2090 579 54 2009 197 923 M11863 GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. 44/49 Gene Ontology BP GO:0051058 0.00367729585406488 0.0101592463568013 1235 1507.72727272727 1321 0.000334859715396341 646 1.28936194274904 1.19832918343306 1 8.77561129400104 1233 2169 2041 1321 646 877 875 1874 1164 1866 2519 924 M15330 GO_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron. 879/1295 Gene Ontology BP GO:0030182 2.81079082437937e-06 4.24630185254455e-05 945 1725.72727272727 1322 2.81079437963097e-07 129 1.22851526516186 1.26345582475101 1 18.3526930360532 944 1298 4548 1179 2559 1322 1165 2082 1780 129 1977 925 M14458 GO_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DIFFERENTIATION.html The establishment of the sex of an organism by physical differentiation. 281/438 Gene Ontology BP GO:0007548 0.000273903912727633 0.0015950874917668 1325 1347 1323 2.49034563815521e-05 412 1.27216096218138 1.18617252635837 1 12.1556900673419 1323 1945 412 1532 1609 955 1098 2344 1802 516 1281 926 M13878 GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 549/752 Gene Ontology BP GO:1901699 0.0055841929007094 0.0134540021460564 550 1607.72727272727 1324 0.000559827517509036 490 1.10218575486983 1.12977948453859 1 7.04041443850168 549 1324 4457 2348 2215 531 818 1733 2225 490 995 927 M13415 GO_BLOOD_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. 412/539 Gene Ontology BP GO:0048514 7.26457186130581e-18 3.38020528706559e-15 705 1416.63636363636 1325 6.60415623755073e-19 7 1.35293832812732 1.39701677988858 1 66.927019276972 701 2470 7 2485 2289 1325 1396 1187 2788 91 844 928 M10056 GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 541/699 Gene Ontology BP GO:0033674 0.00668328559562155 0.0150228637084189 1100 1738.36363636364 1326 0.00067034709254135 505 1.18330225132589 1.20810569947396 1 7.36555418914007 1098 1326 4221 1093 3439 505 1065 2041 2391 506 1437 929 M10676 GO_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 31/35 Gene Ontology BP GO:0051125 0.0146158496837656 0.0277016491155037 1330 1496.63636363636 1326 0.00133762399329975 242 0.979232444467052 -0.99510587911891 -1 5.20374152871048 1326 2711 3394 1142 2027 242 326 1715 486 2400 694 930 M14192 GO_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REMODELING.html The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. 116/161 Gene Ontology BP GO:0048771 3.33692330613384e-07 6.69254488941411e-06 1330 1581.18181818182 1327 3.03356710206627e-08 172 1.51253552315549 1.47738575664196 1 26.7476502413451 1327 769 176 1064 4269 2644 2472 1499 2350 172 651 931 M15486 GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. 50/71 Gene Ontology BP GO:0035914 0.0122544834913741 0.0241303900488209 155 1369.63636363636 1327 0.00112029825103938 152 1.30905973064938 1.49706779762748 1 7.22834254558954 152 2648 818 2300 1605 498 944 1327 2497 1578 699 932 M11810 GO_REGULATION_OF_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_FORMATION.html Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. 27/52 Gene Ontology BP GO:0003156 0.000455478145622286 0.00228623496394876 875 1554.54545454545 1328 4.14156793744801e-05 241 1.37135183746459 1.28687098184871 1 12.3713097727521 873 3118 1328 2705 281 705 540 3162 2534 1613 241 933 M11998 GO_FOREBRAIN_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_CELL_MIGRATION.html The orderly movement of a cell from one site to another at least one of which is located in the forebrain. 67/93 Gene Ontology BP GO:0021885 0.0136199046840881 0.0262204536414665 1305 2204.18181818182 1329 0.00124590561939161 738 1.38462093792601 1.44027430218175 1 7.47540936270928 1302 3704 1090 4237 4365 1329 803 738 3131 989 2558 934 M13663 GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. 115/139 Gene Ontology BP GO:0051351 0.0149232351768923 0.0281694982872535 1485 1586.81818181818 1330 0.00136594869768515 12 0.668707905575833 -0.643063429921005 -1 3.53357184542562 107 12 4132 1330 1024 560 677 1484 2301 4344 1484 935 M14928 GO_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. 84/111 Gene Ontology BP GO:0030510 0.0120416057282348 0.0238251732860758 1350 1620.27272727273 1331 0.00110072949618278 341 1.34452473731965 1.18086913239213 1 7.449874155645 967 2593 816 1348 3272 341 1014 3818 974 1331 1349 936 M13771 GO_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 30/44 Gene Ontology BP GO:0033198 0.00345462480760827 0.00973024771779739 4490 2360 1332 0.00031455104595142 626 1.47007980039538 -1.5259369357529 -1 10.1012790152578 4487 977 1332 747 626 3490 4038 4212 937 857 4257 937 M10722 GO_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that modulates the frequency, rate or extent of developmental growth. 335/478 Gene Ontology BP GO:0048638 8.75644472309613e-05 0.000674565187029243 1315 1372.36363636364 1335 7.96072115156271e-06 196 1.27855532830734 1.28114622574907 1 13.8506674468282 1313 1362 347 196 2756 1562 1935 2703 1286 301 1335 938 M13999 GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION.html The modification of peptidyl-glutamic acid. 24/35 Gene Ontology BP GO:0018200 0.0137413585307651 0.0263889649905717 3615 1665 1335 0.0012570860149783 64 1.57950192518326 -1.4996140418363 -1 8.51402587675421 3613 326 1335 292 1960 3216 4492 741 64 1354 922 939 M10908 GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE.html The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. 15/15 Gene Ontology BP GO:0016254 0.01230383938353 0.0242070886475963 1130 1816.90909090909 1336 0.0011248358311608 212 0.51997147664242 -0.526112368651848 -1 2.86229164786962 1130 1793 3760 3054 1336 212 490 1206 1578 4458 969 940 M13195 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. 191/225 Gene Ontology BP GO:2001236 0.0139004960364626 0.0266278337001484 850 1744.45454545455 1336 0.0012717372625073 839 1.12684018247812 1.17347652931354 1 6.05589990248826 846 2959 839 2695 2082 909 1123 2013 3222 1336 1165 941 M10408 GO_AXO_DENDRITIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXO_DENDRITIC_TRANSPORT.html The directed movement of organelles or molecules along microtubules in neuron projections. 39/46 Gene Ontology BP GO:0008088 0.00419936997480606 0.011127373856932 1020 1949.54545454545 1337 0.000382491567060087 112 1.07333419302755 -1.0066762010545 -1 7.1584375501846 2040 4071 3700 2682 1006 1016 917 1020 1337 3544 112 942 M10492 GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that stops or reduces the activity of a transporter. 64/102 Gene Ontology BP GO:0032410 0.0182182923927555 0.0329971640729823 785 1368.63636363636 1337 0.00167008467369732 357 0.974003083210816 0.948703944872963 1 4.92290686094798 781 1524 2117 1337 2298 411 357 1220 1858 1855 1297 943 M11375 GO_CARDIAC_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MYOFIBRIL_ASSEMBLY.html The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. 22/41 Gene Ontology BP GO:0055003 0.000941329661333806 0.00379549992563795 410 1580.81818181818 1337 8.56120614722699e-05 172 1.3180480317112 1.26798037144643 1 10.8979666696021 410 3156 1337 3038 2385 1064 201 172 3797 1548 281 944 M11915 GO_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. 60/112 Gene Ontology BP GO:0031016 0.00511689951430058 0.0128280891379529 1785 1539.54545454545 1338 0.000466258147390731 379 1.23566982666919 1.21824790425894 1 7.98176669756388 1783 855 1130 379 742 3569 2165 1723 642 1338 2609 945 M13372 GO_PHOSPHATE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSPORT.html The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/20 Gene Ontology BP GO:0006817 0.000141049448999561 0.000978096998800237 1715 1333 1338 1.28234993608275e-05 45 1.59463958507442 1.81109589448379 1 16.397741393816 1714 2875 2048 1984 1038 1338 304 45 519 1960 838 946 M12099 GO_RESPONSE_TO_MAGNESIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MAGNESIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. 25/45 Gene Ontology BP GO:0032026 0.0116199459691292 0.023195027282007 1340 1858.18181818182 1339 0.00106197980254287 336 1.75008494282421 1.91832100080387 1 9.76991249649832 1339 3464 1214 3698 4514 1754 934 691 1062 1434 336 947 M13752 GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of chemokine production. 60/101 Gene Ontology BP GO:0032722 0.00556775952590909 0.0134540021460564 415 1925.45454545455 1339 0.000507445503568671 415 1.28991315982882 1.40863783908595 1 8.24137390871882 415 4035 967 4198 3364 1415 825 469 3335 1339 818 948 M11655 GO_UV_PROTECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_UV_PROTECTION.html Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. 12/13 Gene Ontology BP GO:0009650 1.03629179620251e-05 0.000131744965238532 1340 1932.18181818182 1340 9.42087888728598e-07 28 0.709653010254033 0.737724427273518 1 9.40389583198144 1340 2386 2662 3007 28 1154 165 333 4651 4482 1046 949 M12384 GO_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that modulates the frequency, rate, or extent of a homeostatic process. 468/664 Gene Ontology BP GO:0032844 5.36306817900496e-08 1.45931907818188e-06 760 1427.45454545455 1340 4.87551664522147e-09 127 1.22741840252684 1.30527635362223 1 24.4793577524903 759 1340 127 1767 3494 1730 1240 834 2484 298 1629 950 M14527 GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros. 18/26 Gene Ontology BP GO:0072010 0.0285764057394789 0.0474959513292895 885 1659.63636363636 1341 0.00263222600566809 754 1.36062099328653 -1.59609646511396 -1 6.14538732812199 881 3183 1475 2014 3748 1289 1341 999 969 1603 754 951 M13441 GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. 36/46 Gene Ontology BP GO:0038034 0.0421435743630115 0.0649091632348636 1350 1488.72727272727 1342 0.00390665645734401 246 0.913280125987076 1.06124200199508 1 3.69786031247076 1349 246 2646 893 2575 906 1342 1185 514 3110 1610 952 M14840 GO_STRIATED_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_PROLIFERATION.html The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. 24/29 Gene Ontology BP GO:0014855 0.0017871509239255 0.00604332358214052 1015 1273 1342 0.000162600395791326 70 1.17861677416108 1.1811591386607 1 8.92997185543052 1011 1045 1451 1280 1956 1342 1713 246 2532 1357 70 953 M15288 GO_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_BEHAVIOR.html The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. 194/330 Gene Ontology BP GO:0007626 3.27177103425974e-05 0.000326685635674047 1130 1658 1342 2.97438153820545e-06 298 1.31855602388182 1.21736453309485 1 15.703895833505 1128 1987 298 1730 3637 622 955 4266 1798 475 1342 954 M10257 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 278/369 Gene Ontology BP GO:0090287 3.17577087574491e-09 1.15444233475321e-07 670 1088.45454545455 1344 2.88706443666294e-10 93 1.29891922319677 1.30025837253403 1 30.7989014237042 670 1377 93 2309 1747 239 1383 1344 2368 196 247 955 M11016 GO_RESPONSE_TO_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANGIOTENSIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. 21/29 Gene Ontology BP GO:1990776 0.00785806650666197 0.0170837024786771 3410 1751.45454545455 1345 0.000716934135611978 438 1.35496563336911 1.27673170159894 1 8.17700048702126 3406 1703 1345 438 846 1557 1164 3083 863 1088 3773 956 M11264 GO_CAMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 13/17 Gene Ontology BP GO:0006171 0.00176260977340451 0.00599081320354359 1095 1856.90909090909 1346 0.000160365776196056 66 1.08096555164175 1.10923556356502 1 8.20322607350099 1095 2876 1346 3469 3336 767 66 586 4224 1498 1163 957 M15995 GO_MESENCHYME_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_MORPHOGENESIS.html The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. 47/58 Gene Ontology BP GO:0072132 1.39913138993678e-05 0.000169535373889996 985 1419.54545454545 1346 1.27194571641392e-06 118 1.56769322631801 1.50654100192679 1 20.1999764531294 981 2653 265 2580 2581 1346 784 1742 2123 442 118 958 M13960 GO_ANDROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 23/68 Gene Ontology BP GO:0008209 0.000308396852041102 0.00174060392807767 2005 1827.36363636364 1347 2.8040008337945e-05 231 2.01468524262989 -2.0705479283717 -1 18.9956796944788 2003 2762 993 1001 231 4091 4334 574 1490 1275 1347 959 M16202 GO_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 145/242 Gene Ontology BP GO:0044070 0.0292730382230402 0.0483519513140951 1135 1785.72727272727 1348 0.00269726882041078 780 1.22589452544916 1.37561942009539 1 5.50331189828143 1131 2977 973 2531 2348 780 1336 1032 3634 1348 1553 960 M16936 GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 37/58 Gene Ontology BP GO:0002067 0.0377887742885681 0.0594626874415649 3175 1910.18181818182 1348 0.00349581020236577 225 1.23337226880869 1.13289949905825 1 5.15814567956546 3175 225 1137 377 1348 3357 2491 2426 682 1344 4450 961 M14700 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. 36/46 Gene Ontology BP GO:0097192 0.0970501328535741 0.130512794268116 1350 1526.81818181818 1350 0.00923781632909501 247 0.913280125987076 1.06124200199508 1 2.75067219958427 1350 247 2647 894 2576 907 1343 1594 515 3111 1611 962 M15523 GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. 396/638 Gene Ontology BP GO:0002683 1.74604030679074e-09 7.00372892025631e-08 1060 1559.18181818182 1350 1.58730937106954e-10 86 1.2340294770797 1.28843434580237 1 30.175478429753 1059 1350 86 493 4245 1838 1936 960 2606 111 2467 963 M10052 GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 12/19 Gene Ontology BP GO:0071402 0.00727142402397297 0.0161319904907327 1355 1764.27272727273 1351 0.000663233571147293 823 1.63253041659096 1.64615320621651 1 9.99319072249337 1351 2385 1248 1027 823 1528 1244 3277 3625 1951 948 964 M15386 GO_CEREBELLAR_CORTEX_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_FORMATION.html The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 28/45 Gene Ontology BP GO:0021697 0.025680567065498 0.0435782926899205 305 1813.90909090909 1352 0.00236230256260983 303 1.47816425724209 -1.33117404421534 -1 6.86614695394841 2680 303 953 304 1352 3379 2377 3481 769 736 3619 965 M16868 GO_CELLULAR_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 37/52 Gene Ontology BP GO:0071312 0.0297560160788105 0.0489087881882097 1355 1678.36363636364 1352 0.00274238815521547 477 1.15836992468075 -1.19447983207746 -1 5.17989700329539 1042 2193 1352 2790 2025 1351 702 1839 3348 1343 477 966 M10113 GO_LIPID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_MODIFICATION.html The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. 198/244 Gene Ontology BP GO:0030258 0.00577426225782821 0.0134540021460564 1355 1639.54545454545 1353 0.000526315789473684 53 1.10344139978391 -1.09829032881063 -1 7.04844724890099 3612 685 1449 53 1351 2252 4198 1353 550 1408 1124 967 M13323 GO_HEART_VALVE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_FORMATION.html The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. 21/24 Gene Ontology BP GO:0003188 0.00303150574204406 0.00884183924845716 1070 1759.54545454545 1353 0.000275971918495461 331 1.36079133931946 1.52412825267578 1 9.54299432914043 1067 3502 1548 4332 692 1353 620 331 3018 2429 463 968 M11712 GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 59/69 Gene Ontology BP GO:0070849 0.0396151918577193 0.0618048597965753 450 1269.45454545455 1355 0.00366791425560958 135 1.00453390969972 1.0815184885321 1 4.14150789013357 447 135 1355 678 1616 727 1515 1802 3587 1533 569 969 M14391 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND.html The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. 24/35 Gene Ontology BP GO:0050910 0.00291521825007197 0.00855805079973809 70 1596.54545454545 1355 0.000265371671363617 66 1.29039570228121 1.40000933284287 1 9.11127553210356 66 3139 620 2473 1514 912 849 1641 4454 1355 539 970 M14635 GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. 23/38 Gene Ontology BP GO:0002367 0.000539438653432765 0.00255341612860901 110 1434.09090909091 1355 4.90519062621611e-05 20 1.24023402159247 1.21774193137016 1 10.9839062276508 106 2774 1677 3382 1355 245 20 930 3144 1681 461 971 M15042 GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of muscle tissue development. 64/88 Gene Ontology BP GO:1901863 0.0762056197653602 0.106212802090958 1815 1385.18181818182 1355 0.00718007776166603 112 1.17473867115972 1.25043297042294 1 3.90057099327908 1814 112 1235 900 1621 1179 1355 2187 983 1858 1993 972 M11582 GO_RESPONSE_TO_GRAVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GRAVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. 14/20 Gene Ontology BP GO:0009629 0.000481181219556011 0.00236863601522557 1055 1504.63636363636 1356 4.37533177401516e-05 104 1.50344448614844 1.85026068589328 1 13.4849346245934 1054 1813 1356 3198 735 3013 1903 104 575 2216 584 973 M14757 GO_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLATION.html The covalent attachment of a fucosyl group to an acceptor molecule. 24/29 Gene Ontology BP GO:0036065 5.28244542389148e-05 0.000472677279949367 50 1492.81818181818 1356 4.80233842323899e-06 14 1.307320890525 1.38022880902042 1 14.8529067222956 49 3475 1832 2771 3932 268 65 14 2591 1356 68 974 M12969 GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. 28/34 Gene Ontology BP GO:0030201 0.00577426225782821 0.0134540021460564 1080 1356.72727272727 1357 0.000526315789473684 68 1.30593980746627 -1.38371360196075 -1 8.34390211582974 1076 298 1357 68 3160 2616 1229 1493 343 1714 1570 975 M10531 GO_CIRCULATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. 359/596 Gene Ontology BP GO:0003013 1.8090560351433e-18 1.15413214315187e-15 500 1254.45454545455 1358 1.64459639558482e-19 5 1.2935452908887 1.28535186659815 1 66.0524574847919 496 1358 5 1739 2667 1420 1424 829 2919 48 894 976 M12331 GO_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 56/70 Gene Ontology BP GO:0044042 0.00206948471875561 0.00666209563659403 655 1360.81818181818 1359 0.000188312181691487 522 0.959380527850022 0.961004099279622 1 7.12804933928497 652 861 3101 789 522 1601 1359 1525 733 2286 1540 977 M12779 GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the cytosol. 53/99 Gene Ontology BP GO:0060401 0.0130157822280474 0.0253399308397926 1265 1569.63636363636 1361 0.00119031190483327 161 1.06958478774099 1.03480639599855 1 5.82638795295024 1261 161 828 1766 1361 1849 1268 1901 3936 968 1967 978 M11811 GO_FOREBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 391/610 Gene Ontology BP GO:0030900 9.97194239229898e-07 1.70586205703556e-05 905 1508.18181818182 1362 9.06540628389569e-08 207 1.20956285825291 1.26417950746269 1 19.7073078854406 902 1930 207 3099 1656 1076 1305 1957 2743 353 1362 979 M12385 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE.html A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 14/15 Gene Ontology BP GO:0033540 0.00170744835052267 0.00585896546827581 1365 2042.27272727273 1362 0.000155343178623467 234 0.820134272902783 -0.881812432736769 -1 6.24835825517171 1362 3557 3330 3476 1206 530 523 234 3764 3849 634 980 M15458 GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 13/32 Gene Ontology BP GO:0045408 0.00664888082128735 0.0149527513105124 750 1530 1363 0.00060627823881487 180 1.11007636775626 1.14973157515388 1 6.91680489148331 749 1186 1363 2311 1908 345 180 3650 1712 2106 1320 981 M13073 GO_ENDODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. 55/73 Gene Ontology BP GO:0035987 7.27868033908556e-05 0.000588256948185597 60 1477.18181818182 1364 6.6172010588445e-06 57 1.45752599750915 1.49933037677231 1 16.0872458203374 57 2636 332 1646 1821 1272 1364 1232 3637 847 1405 982 M13563 GO_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENTATION.html The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. 100/137 Gene Ontology BP GO:0035282 0.00243920206663795 0.00745703496456397 190 1325.36363636364 1364 0.000221991880371507 39 1.24349947009443 1.15187012442191 1 9.03403547317755 187 2575 1364 2872 1983 39 90 1099 1950 2299 121 983 M10344 GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. 18/23 Gene Ontology BP GO:0046337 0.00200372917565867 0.00652438898134344 4315 2169.36363636364 1365 0.000182323315866532 67 1.53156059025761 -1.76718647571436 -1 11.4331170576989 4314 1122 1365 82 516 4448 3122 3458 67 813 4556 984 M15450 GO_CHOLESTEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 11/19 Gene Ontology BP GO:0006707 0.0460748264073338 0.0696285051228724 1225 2169.18181818182 1365 0.00427900476799364 629 1.24950067142426 1.13106235580798 1 4.93292433504218 1223 3584 1319 3695 3602 1277 629 1365 4288 1238 1641 985 M10527 GO_RESPONSE_TO_COLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COLD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. 62/78 Gene Ontology BP GO:0009409 0.00420986372681561 0.0111424891472543 1065 1691 1366 0.000383449205673847 106 1.38742023884857 1.34053890417123 1 9.25350989953892 1063 3709 660 2841 1366 106 215 3471 3358 1429 383 986 M10868 GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 20/20 Gene Ontology BP GO:0090153 0.000365916694154204 0.00195321638000782 2350 1308.09090909091 1366 3.32706881550777e-05 254 0.946799319245847 1.25888496553223 1 8.75933292653666 2347 394 2452 429 254 1366 2243 1997 376 1839 692 987 M11394 GO_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 74/100 Gene Ontology BP GO:0005976 0.0594217716155281 0.0861875010371111 975 1517.18181818182 1366 0.00555365351725746 102 1.07297145486912 1.07277899577913 1 3.8945885071302 972 102 2976 775 2778 1345 2064 1366 698 2114 1499 988 M15972 GO_MATERNAL_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PLACENTA_DEVELOPMENT.html Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 33/41 Gene Ontology BP GO:0001893 0.00577426225782821 0.0134540021460564 2295 1500.09090909091 1366 0.000526315789473684 71 1.32197327227737 1.56059040261992 1 8.446473934843 2294 242 1366 121 1459 3843 3341 1685 71 1060 1019 989 M11494 GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. 20/20 Gene Ontology BP GO:1905038 0.000365916694154204 0.00195321638000782 2350 1293.63636363636 1367 3.32706881550777e-05 255 0.946799319245847 1.25888496553223 1 8.75933292653666 2348 395 2453 430 255 1367 2244 1828 377 1840 693 990 M12668 GO_REGULATION_OF_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of heart morphogenesis. 28/47 Gene Ontology BP GO:2000826 0.000870487604173515 0.00360116938852812 1280 1677.36363636364 1367 7.91665660276452e-05 376 1.33865170065463 1.30369779749052 1 11.1729568847539 1276 3116 1720 2199 376 1314 1367 2341 2943 1335 464 991 M11734 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 71/88 Gene Ontology BP GO:0001837 0.000112440531369293 0.000822619170536664 990 1380.54545454545 1368 1.02223889582747e-05 357 1.39807432601896 1.45015173554267 1 14.7345096698292 989 2112 357 2215 2624 1559 976 1368 1495 361 1130 992 M12058 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation. 133/174 Gene Ontology BP GO:0030856 5.99042045070229e-06 8.19806657562286e-05 1710 1437.81818181818 1368 5.44585160199132e-07 249 1.34518227380085 1.13496989354654 1 18.7826172644103 1710 751 249 1470 3329 311 658 3509 1932 529 1368 993 M16583 GO_HEMOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOSTASIS.html The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. 303/448 Gene Ontology BP GO:0007599 2.77434570955483e-05 0.00028686734636797 725 1384.90909090909 1368 2.52216426955401e-06 290 1.19376502591003 1.15325879923863 1 14.4470277265877 721 1368 290 2757 886 1291 1526 1962 1869 655 1909 994 M13745 GO_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_POLARITY.html The maintenance of established anisotropic intracellular organization or cell growth patterns. 12/17 Gene Ontology BP GO:0030011 5.57828913209462e-05 0.000487890588940531 2175 1197.63636363636 1369 5.07130052675666e-06 9 1.16977643194926 -1.07208025089766 -1 13.2340739669447 2172 1172 2114 123 98 1442 2285 725 9 1369 1665 995 M15585 GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 30/49 Gene Ontology BP GO:0032350 0.000381216181573019 0.00200025261221394 2155 1372.54545454545 1369 3.46620231612562e-05 431 1.47795966121325 1.28447997328964 1 13.6271345091266 2155 992 431 1779 2116 1369 842 1635 1657 859 1263 996 M13810 GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS.html Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. 47/71 Gene Ontology BP GO:0021952 0.0117849016967366 0.0234438424946196 585 1703.45454545455 1371 0.00107713711604903 264 1.12761311823975 1.1134167276558 1 6.27328361739061 583 3049 1371 2945 3081 483 264 837 4108 1705 312 997 M10455 GO_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. 278/408 Gene Ontology BP GO:0007517 2.52305830996547e-09 9.70230604650359e-08 765 1297.54545454545 1374 2.29368937532638e-10 90 1.26619916112253 1.26710631051324 1 30.3496345579288 765 1374 90 1722 2265 1711 1980 940 2325 128 973 998 M11372 GO_ORGANOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. 809/1043 Gene Ontology BP GO:0019637 0.0264674511875162 0.0446485606997131 1110 1654.54545454545 1374 0.0026788075637189 398 0.996014662336921 -0.926591235799141 -1 4.58717723626123 1109 585 4295 454 2489 398 1232 2525 1374 2008 1731 999 M16040 GO_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_PHOSPHORYLATION.html The modification of histones by addition of phosphate groups. 37/59 Gene Ontology BP GO:0016572 0.0101159926197179 0.0208273069290032 1875 1748.36363636364 1374 0.000923891765323824 252 0.818195520876985 0.90012471298302 1 4.69273822493509 1871 252 3320 1937 1202 1374 1235 641 1186 3980 2234 1000 M11533 GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. 22/36 Gene Ontology BP GO:1903306 0.00273953622842793 0.00817119363517639 1015 1351.63636363636 1375 0.000249359416169044 91 1.00981227386839 0.999078029588433 1 7.19716118946939 1014 1054 2651 1375 1709 1162 91 1510 318 2058 1926 1001 M13401 GO_EXOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCRINE_SYSTEM_DEVELOPMENT.html Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. 61/75 Gene Ontology BP GO:0035272 0.00130297256540182 0.0048231752957953 1565 1312.63636363636 1375 0.000118522264067312 129 1.2156065484609 1.27630828373652 1 9.6176248014609 1562 129 678 383 435 2420 1568 1375 2618 929 2342 1002 M16129 GO_NEGATIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXONOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. 83/105 Gene Ontology BP GO:0050771 0.00337647402417839 0.00957387790036689 840 1240.90909090909 1376 0.000307424296957199 352 1.46461601954842 1.53170686849333 1 10.0989288528812 837 2094 634 1376 1488 1779 947 1917 1480 746 352 1003 M16534 GO_BIOLOGICAL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOLOGICAL_ADHESION.html The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. 953/1424 Gene Ontology BP GO:0022610 1.52210087079192e-18 1.15413214315187e-15 535 1806.36363636364 1378 1.52210087079192e-19 2 1.34379022685955 1.33689455866515 1 68.618534814236 532 2440 4632 2734 2649 337 1340 1378 2994 2 832 1004 M11774 GO_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSPORT.html The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. 26/32 Gene Ontology BP GO:0006862 0.017713162344691 0.0322454399021311 960 1735.36363636364 1379 0.00162340066702578 819 0.930269788355309 -0.866436512850359 -1 4.73321863293778 958 1673 3305 2095 3054 824 1011 819 1379 2839 1132 1005 M12381 GO_PATTERNING_OF_BLOOD_VESSELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERNING_OF_BLOOD_VESSELS.html The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. 62/76 Gene Ontology BP GO:0001569 0.00266001527307097 0.00796976887675417 175 1759.09090909091 1379 0.000242112449689897 87 1.28564115484584 1.40210384751353 1 9.21361537816235 173 2622 653 2732 3139 1340 1186 1379 3712 2327 87 1006 M13460 GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. 70/97 Gene Ontology BP GO:0042439 0.000339732608774533 0.00186130320683188 4195 2025.09090909091 1380 3.08895529962097e-05 17 1.37591235088542 -1.34090138777436 -1 12.8325869017782 4192 100 507 17 1380 4310 4120 4512 579 279 2280 1007 M10696 GO_SALIVARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SALIVARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. 48/55 Gene Ontology BP GO:0007431 0.00982019831948359 0.0203171999913549 835 1486.18181818182 1381 0.000896755354821048 391 1.19781274114108 1.28587164776653 1 6.9190725888178 833 1574 1032 2846 904 1381 391 1644 3478 1450 815 1008 M13912 GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. 15/21 Gene Ontology BP GO:0002921 0.00481718668404892 0.0122751202852572 965 1466.09090909091 1382 0.000438887908182506 241 1.06792135267903 1.11411537974382 1 6.96662319104279 961 1787 1382 1514 724 602 241 1617 3913 2369 1017 1009 M10750 GO_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION.html A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 54/59 Gene Ontology BP GO:0006635 0.00087628368156796 0.00361278190941396 1280 1702.54545454545 1383 7.9693900868022e-05 168 0.763347532934238 -0.768623497974352 -1 6.36299189180468 1279 168 3716 398 379 777 1663 1383 3098 4114 1753 1010 M16677 GO_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERK1_AND_ERK2_CASCADE.html An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 22/29 Gene Ontology BP GO:0070371 0.0100675496467864 0.0207459293651449 2200 1691 1383 0.000919447062717405 376 1.41254604811838 1.7881515630264 1 8.11757623225849 2196 376 1020 879 3251 2302 1354 638 3647 1555 1383 1011 M15388 GO_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_SECRETION.html Any process that modulates the frequency, rate, or extent of peptide secretion. 224/327 Gene Ontology BP GO:0002791 0.000201063821197895 0.00126920469882024 740 1634.36363636364 1384 1.82801999367314e-05 391 1.23129851055979 1.18454282767939 1 12.1827298012667 737 1384 391 2008 4371 1390 1049 2182 2792 427 1247 1012 M15953 GO_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXECUTION_PHASE_OF_APOPTOSIS.html A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. 63/76 Gene Ontology BP GO:0097194 0.00921347103622837 0.0193983170731089 1230 1848.54545454545 1385 0.000841116751904222 140 0.866669387471298 -0.87599200887294 -1 5.06285851490652 1226 140 3445 1119 885 2486 3551 1876 1385 3210 1011 1013 M16294 GO_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXONOGENESIS.html Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. 197/250 Gene Ontology BP GO:0050770 7.69614495003139e-05 0.000613187713227672 1015 1589.45454545455 1385 6.99674017584715e-06 337 1.2900567451681 1.30808519264321 1 14.1580936848226 1013 1980 337 1253 2179 1385 1743 3901 1931 452 1310 1014 M16887 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. 281/394 Gene Ontology BP GO:0032102 1.71238359307757e-15 4.1935372939947e-13 1385 1451.72727272727 1385 1.55671235734324e-16 14 1.52099513454905 1.55515297951669 1 64.3544229625709 1385 1373 14 717 3497 2239 2253 1967 1890 59 575 1015 M12248 GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. 19/22 Gene Ontology BP GO:0030970 0.000410322753845915 0.0021119820504923 1205 1702.36363636364 1386 3.7309027570204e-05 273 0.848897936878766 -0.794306549938696 -1 7.75398882788182 1201 2310 3731 1131 273 1113 806 1639 1488 3648 1386 1016 M13119 GO_GAS_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAS_TRANSPORT.html The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/23 Gene Ontology BP GO:0015669 7.45320333349063e-05 0.000599254438276232 3100 1938.63636363636 1387 7.45345332137074e-06 125 1.76156603563551 -1.77014546531285 -1 19.3968230377804 3096 1234 4408 964 125 2534 3680 1387 1323 560 2014 1017 M11155 GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. 81/125 Gene Ontology BP GO:0044259 6.56391948030872e-15 1.38826897008529e-12 60 1139.09090909091 1388 5.9671995275534e-16 17 1.5620525013752 1.49988845038605 1 63.3153498909692 60 1489 17 1447 581 1359 1427 1437 3145 180 1388 1018 M11553 GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 233/320 Gene Ontology BP GO:0071229 6.55676625614634e-10 2.85127414858401e-08 970 1465.54545454545 1388 5.96069659827315e-11 77 1.25513317822459 1.2111916181115 1 32.3665327449356 970 1959 77 1566 1216 1388 2258 2110 3375 203 999 1019 M12476 GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. 10/12 Gene Ontology BP GO:0006677 0.000688723041143847 0.00305785144126176 1390 1446.90909090909 1390 6.26307949562286e-05 1 1.42536233176083 1.95347957172358 1 12.2435037434082 1390 527 2455 156 3999 1621 834 141 1 3019 1773 1020 M15278 GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. 187/372 Gene Ontology BP GO:0071824 0.0131000447305998 0.0254826539011208 480 1846.27272727273 1390 0.00119806421356715 221 1.06822317472549 -1.1900647073795 -1 5.81004866009004 477 1993 3370 2306 4353 221 1095 1390 978 3350 776 1021 M11580 GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that activates or increases the frequency, rate, or extent of a homeostatic process. 205/279 Gene Ontology BP GO:0032846 0.0118352216157311 0.0235137857292897 960 1498.81818181818 1391 0.00108176132839172 696 1.18739366721096 1.23619324134419 1 6.60117560984831 960 1391 1095 1807 2917 1681 945 696 2092 1016 1887 1022 M14099 GO_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. 961/1416 Gene Ontology BP GO:0006629 1.83118471640231e-07 4.0191049459528e-06 3210 1811 1391 1.83118486729801e-08 2 1.15792591514053 -1.09150796613661 -1 21.3509836299786 3208 575 4473 2 1391 992 3741 2766 957 84 1732 1023 M14946 GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 143/207 Gene Ontology BP GO:0051896 0.00251476243591266 0.00765784660621833 1145 1497.90909090909 1392 0.000228876509422702 176 1.23092912475697 1.26581385543366 1 8.89403609138975 1143 2020 765 1392 2652 958 1747 1640 3581 403 176 1024 M15026 GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 1034/1522 Gene Ontology BP GO:0071495 7.89190602243727e-07 1.40971618572432e-05 860 1626.45454545455 1392 7.89190882513679e-08 101 1.18870502852131 1.18668851544922 1 19.7038479248879 860 1282 4531 1463 2564 465 1318 1606 2309 101 1392 1025 M15722 GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. 200/298 Gene Ontology BP GO:0090257 1.31772117480249e-07 2.96200803205604e-06 1120 1505.54545454545 1392 1.19792841248116e-08 97 1.24592740349444 1.26043519604329 1 23.5390543864607 1120 1392 156 741 3270 1341 2035 2086 2271 97 2052 1026 M10876 GO_NEGATIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. 191/243 Gene Ontology BP GO:0030308 0.0125039690395007 0.0245385777902982 1140 1484.18181818182 1394 0.00114323705106867 259 1.2506941231423 1.35253654093575 1 6.87443369715227 1136 2960 824 2359 2094 1750 1595 1239 1394 716 259 1027 M12980 GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a symbiont organism effects a change in the structure or processes of its host organism. 52/81 Gene Ontology BP GO:0044003 0.0348511908185912 0.0556113137444803 1225 1846.45454545455 1394 0.00321962251150332 118 1.34228727696402 1.56205888389453 1 5.74804652251724 1221 3360 3031 865 4450 1394 714 2577 118 2056 525 1028 M14927 GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. 104/168 Gene Ontology BP GO:0055067 0.01565269113431 0.0292380457037111 1395 1971.72727272727 1394 0.00143319817459887 779 1.22941118268093 1.47681443691452 1 6.43740455085295 1394 2574 903 4115 4078 1101 1238 779 2644 1774 1089 1029 M10506 GO_ICOSANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. 37/58 Gene Ontology BP GO:0046456 1.85304187437419e-05 0.000210297654669832 3770 1777.81818181818 1395 1.68459771143389e-06 122 1.70567642504394 -1.84874079774331 -1 21.4331619982536 3770 1611 273 957 122 3241 1320 1395 2359 212 4296 1030 M13610 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. 196/249 Gene Ontology BP GO:0048872 0.0498672531352762 0.0744409139680591 900 1550.81818181818 1395 0.00463952858272045 390 1.08283467918759 1.16027510721182 1 4.16606499541564 898 1395 2160 390 3185 2180 1557 1270 1112 1200 1712 1031 M16318 GO_MITOTIC_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. 12/13 Gene Ontology BP GO:0007064 0.00345294083335845 0.00973024771779739 645 1742.54545454545 1395 0.000314397475125389 266 1.08159808751303 1.08159808751303 1 7.42910812271454 643 2891 3216 1854 3110 932 750 349 266 3762 1395 1032 M16119 GO_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. 126/185 Gene Ontology BP GO:0006766 7.18175333788517e-05 0.000585231143278104 3590 1767.09090909091 1396 6.52907981104574e-06 253 1.28501969392777 -1.28549634689014 -1 14.1918085123518 3587 748 329 253 1911 1396 3146 4011 538 419 3100 1033 M12628 GO_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CONTRACTION.html A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. 219/347 Gene Ontology BP GO:0006936 0.000447518215805005 0.00225601544760638 420 1570.18181818182 1398 4.06917522470058e-05 420 1.17969949858254 1.22613579817311 1 10.6641834491958 420 1971 441 2752 3398 1326 1408 616 3064 1398 478 1034 M14469 GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 89/134 Gene Ontology BP GO:0051897 0.000858632628815972 0.00357314526661381 1820 1544 1398 7.80879932427037e-05 66 1.25268241408208 1.30482508475294 1 10.4692670579602 1818 66 488 810 845 2991 2398 1398 3902 468 1800 1035 M11888 GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS.html Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. 34/50 Gene Ontology BP GO:0044068 0.0154615835492796 0.028992472692172 1400 1822.45454545455 1400 0.00141557534338319 308 1.12516809745527 1.31528736841287 1 5.90475753190115 1079 1640 3084 1400 4406 1398 308 3574 476 2231 451 1036 M13131 GO_ESTABLISHMENT_OF_TISSUE_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_TISSUE_POLARITY.html Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 23/29 Gene Ontology BP GO:0007164 0.00936502061799334 0.0196728852982045 2575 1810 1401 0.000855011373212117 526 1.35585163743714 -1.45991853298512 -1 7.89825758447582 2571 1050 1401 597 4320 772 2932 612 2523 2606 526 1037 M11265 GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. 76/105 Gene Ontology BP GO:1901606 0.00400421075324803 0.0108134606122247 1405 1412.63636363636 1403 0.000364683402325717 666 1.39758804869712 -1.44203059706429 -1 9.38360440213656 1403 1511 1543 971 666 1223 3136 715 1746 1937 688 1038 M14777 GO_POSITIVE_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SIZE.html Any process that increases cell size. 18/21 Gene Ontology BP GO:0045793 0.00805710273946943 0.0174409086496302 1135 1538.90909090909 1403 0.000735160237154836 447 0.848239807361298 0.832791026857211 1 5.0889403067434 1134 447 2821 1403 852 1894 995 583 1772 2652 2375 1039 M12564 GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS.html The cellular component assembly that is part of the initial shaping of the component during its developmental progression. 274/381 Gene Ontology BP GO:0010927 0.0378500509745552 0.0595188533912151 1925 1629.18181818182 1404 0.00350157951223839 486 1.13879175966327 -1.18544706285313 -1 4.7601818915076 1925 662 1316 691 4478 486 2099 2874 1404 1423 563 1040 M10923 GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. 33/56 Gene Ontology BP GO:0045762 0.00761364775479936 0.0166790503780986 1825 1633.54545454545 1405 0.000694556822857704 561 1.30891414353372 1.20861845477638 1 7.94531364684368 1823 2202 1098 982 1166 2722 2570 561 1005 1405 2435 1041 M13770 GO_OXIDATION_REDUCTION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATION_REDUCTION_PROCESS.html A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. 756/1065 Gene Ontology BP GO:0055114 0.0398524900211848 0.0620386872092917 1140 1665.09090909091 1405 0.00405857663506738 588 1.07010997319943 -0.977394300767801 -1 4.40656187111985 1139 588 4448 1166 1405 749 1993 1979 1026 1793 2030 1042 M12731 GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. 178/268 Gene Ontology BP GO:0006109 0.0132167996048552 0.0256240702339131 540 1544.45454545455 1406 0.00120880687618661 538 1.0487875392462 1.09918754342194 1 5.69552634363568 538 1406 1882 2364 2521 635 653 729 2848 2495 918 1043 M14762 GO_RHYTHMIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_PROCESS.html Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. 302/434 Gene Ontology BP GO:0048511 0.0280746986884588 0.0468885760938259 530 1742.36363636364 1406 0.00258540914684608 465 1.17841385837845 1.11037972607763 1 5.34352172799094 527 3961 1659 2871 3941 471 465 1406 2019 1101 745 1044 M16484 GO_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 114/170 Gene Ontology BP GO:0046165 0.00413246821265054 0.0110329917313101 2270 1535.09090909091 1407 0.000376386463050567 9 1.15608430345243 -1.25815019320912 -1 7.72577092526477 2268 9 1023 460 676 2348 3906 1407 1519 1165 2105 1045 M11354 GO_HYPEROSMOTIC_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPEROSMOTIC_RESPONSE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. 22/43 Gene Ontology BP GO:0006972 0.0130120714959065 0.0253399308397926 1410 1339.63636363636 1408 0.0011899705243282 510 0.931295047340561 0.949581538044167 1 5.07169862507718 1408 1688 2005 825 990 510 863 2252 1614 1547 1034 1046 M12046 GO_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). 147/171 Gene Ontology BP GO:0045333 0.000580330093939601 0.00270840113049244 40 1641.27272727273 1408 5.27712030624738e-05 38 0.648424262290918 -0.606736128305524 -1 5.68082884072612 38 2012 4136 1241 314 460 708 1539 1408 4396 1802 1047 M15874 GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 45/58 Gene Ontology BP GO:0072523 0.000325725904379922 0.00181247811833771 4075 2101.09090909091 1410 2.96158309503181e-05 237 1.49110646437014 -1.36237456101158 -1 13.9667025398073 4073 2156 1410 1196 237 2771 4251 1289 419 801 4509 1048 M11946 GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. 10/11 Gene Ontology BP GO:0033262 0.0058210198048635 0.0135223190973689 835 1799.90909090909 1412 0.000530589003846307 372 0.849929142201209 0.849929142201209 1 5.42024651588101 831 2907 3135 2590 766 888 372 1412 880 3616 2402 1049 M13694 GO_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. 35/60 Gene Ontology BP GO:0086003 0.000396520372680717 0.00205457605131779 285 1999.90909090909 1413 3.6053805288785e-05 16 1.08244092966611 1.05302261520803 1 9.93443792753191 282 2701 1092 3531 4612 1413 498 929 3880 3045 16 1050 M15954 GO_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 1400/2148 Gene Ontology BP GO:0048468 5.36149931595649e-09 1.8343423762607e-07 855 1680 1413 5.36149932889204e-10 47 1.19943786803472 1.23728136200451 1 27.6145576066587 851 1266 4583 1170 3058 1588 1413 857 2075 47 1572 1051 M16788 GO_LEUKOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. 64/87 Gene Ontology BP GO:0001776 0.0145903440509367 0.0276835013259455 1150 1680.36363636364 1413 0.00133527408224352 425 0.933652655876505 0.979518831986363 1 4.96193804503182 1147 1522 2733 1413 3741 1209 425 763 1456 3246 829 1052 M10841 GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 517/769 Gene Ontology BP GO:0071407 0.00354859352300254 0.0099288067724178 880 1892.27272727273 1414 0.000355427292348489 379 1.19799247933842 1.23055021857922 1 8.19379301698106 878 1331 4265 3710 2845 379 1414 1748 2757 453 1035 1053 M11139 GO_SECOND_MESSENGER_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECOND_MESSENGER_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. 176/251 Gene Ontology BP GO:0019932 2.2581454022847e-05 0.000244921924401648 770 1946.81818181818 1415 2.052880528085e-06 283 1.08790112067943 1.16879898976595 1 13.4202646898649 770 1407 283 3215 4170 1393 1415 1598 4013 1347 1804 1054 M10857 GO_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ACTIVATION.html A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. 162/224 Gene Ontology BP GO:0030168 0.00014319436211145 0.000987086469488264 1420 1401.45454545455 1417 1.30185166586439e-05 370 1.21166529003557 1.12635474914029 1 12.44058113963 504 1417 370 2400 1103 1418 1285 2263 1875 824 1957 1055 M12122 GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. 15/29 Gene Ontology BP GO:0048557 0.0589937183736845 0.0856734617954913 2520 1870.54545454545 1417 0.00551251944394112 482 1.59389215472093 1.75647714743137 1 5.804720202253 2516 482 1129 1417 2429 1407 1453 4371 758 1261 3353 1056 M13270 GO_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of chemokine production. 76/124 Gene Ontology BP GO:0032642 0.00193972795185943 0.00639120213122408 710 1816.90909090909 1418 0.000176494573948788 569 1.3684771508349 1.57313171365475 1 10.2564709024314 710 3687 569 4149 2263 1745 1418 662 3137 980 666 1057 M16208 GO_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 89/135 Gene Ontology BP GO:0006970 0.0512162157584849 0.0761370772920864 1420 1543.09090909091 1419 0.00476808204203599 69 1.03323437639798 0.998236442362416 1 3.94018140529158 1419 69 1151 1008 2698 1514 1075 2369 2922 800 1949 1058 M16748 GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structure of the retina is generated and organized. 54/80 Gene Ontology BP GO:0060042 0.0115063375295621 0.0230473476216327 1840 1538.27272727273 1420 0.00105154198285104 165 1.25654060156716 1.15690474835576 1 7.02359329775446 1840 165 807 1218 1420 1974 1265 1625 1335 1530 3742 1059 M10560 GO_REGULATION_OF_PROSTAGLANDIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROSTAGLANDIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. 13/18 Gene Ontology BP GO:0032306 0.00181094654014671 0.00609587405331511 1010 1786.90909090909 1421 0.000164767177688984 249 1.3752035994114 1.27063389803478 1 10.4035415385371 1007 2874 2029 3517 524 1191 285 249 4467 2092 1421 1060 M16678 GO_LENS_FIBER_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. 15/29 Gene Ontology BP GO:0070307 0.0468522558691177 0.0706198725490783 555 1502.54545454545 1422 0.00435280412881634 551 1.23085414364113 1.13194715302485 1 4.83331237006698 551 1163 1963 1422 3217 927 639 1702 1000 1770 2174 1061 M15882 GO_NOTOCHORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTOCHORD_DEVELOPMENT.html The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. 39/52 Gene Ontology BP GO:0030903 0.00411411406629596 0.0110143686711594 190 1722 1423 0.000374711625072063 190 1.38183298012473 1.29567774839573 1 9.23993118599346 190 2691 656 2733 1883 1262 1423 2517 3738 905 944 1062 M12753 GO_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_INFLAMMATORY_RESPONSE.html Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. 68/158 Gene Ontology BP GO:0002526 2.73420317353043e-08 7.902016997787e-07 325 1170.81818181818 1424 2.48563927955603e-09 120 1.67655836633073 1.72018042833191 1 34.9678989256425 322 1521 120 2741 1704 1424 921 793 1632 200 1501 1063 M16705 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. 41/61 Gene Ontology BP GO:0002763 0.00523036691472947 0.013042281486729 440 1950.18181818182 1425 0.000476622122018123 440 1.41368566166563 1.29987550718012 1 9.09843069062903 440 3754 1425 3811 3128 1224 1180 447 3675 1626 742 1064 M11740 GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 306/414 Gene Ontology BP GO:0051961 9.17087606721047e-05 0.000699542399028366 1295 1412.54545454545 1426 8.33750762257375e-06 348 1.2610128569488 1.34857288741998 1 13.5924059792176 1295 1941 348 1426 1887 935 1676 2843 2220 519 448 1065 M12245 GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myeloid cell differentiation. 188/290 Gene Ontology BP GO:0045637 0.00640329750392252 0.0145765867347121 410 1817.63636363636 1426 0.000583819197786423 409 1.17667271385703 1.2048080672466 1 7.37691693213971 409 2528 721 2861 4535 1656 1327 565 3214 752 1426 1066 M15357 GO_GOLGI_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_VESICLE_TRANSPORT.html The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. 387/431 Gene Ontology BP GO:0048193 0.00577426225782821 0.0134540021460564 2950 2106 1426 0.000526315789473684 160 0.962929159963731 -0.929185682211741 -1 6.14954010675876 2946 625 4067 160 1426 1036 2870 3555 772 4315 1394 1067 M15379 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. 95/148 Gene Ontology BP GO:1903426 0.00276938660824262 0.0082391022302768 1430 1369.54545454545 1426 0.00025207990015904 414 1.13558495712425 1.28405233631394 1 8.08094445360939 1426 1470 1018 1140 1567 1573 1775 1045 1366 414 2271 1068 M15332 GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 308/352 Gene Ontology BP GO:0010498 0.00577426225782821 0.0134540021460564 685 1838.18181818182 1427 0.000526315789473684 218 0.776921512508012 -0.7869606416156 -1 4.95958254146051 681 649 4185 218 3830 529 1621 1427 1757 4346 977 1069 M15366 GO_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. 146/209 Gene Ontology BP GO:0010001 0.000374239324105158 0.00197796847839223 880 1621.72727272727 1427 3.40275455151476e-05 387 1.19519618521553 1.31554212691249 1 11.037830857938 876 1427 430 1811 4122 1661 1125 1913 3161 387 926 1070 M15529 GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 27/44 Gene Ontology BP GO:0002089 0.00106307028654957 0.00414971983499594 980 1624.63636363636 1427 9.66894840478959e-05 40 1.36819243621498 1.28497164884365 1 11.1317164996083 977 2736 2505 1427 2620 1213 524 2790 533 2506 40 1071 M14005 GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell. 77/145 Gene Ontology BP GO:0050715 0.00593200027719831 0.0137253094429656 1175 1592.18181818182 1428 0.000540732340774399 570 1.38158303512771 1.53664899042071 1 8.78686260313138 1173 2102 712 1821 4359 897 1428 781 1477 570 2194 1072 M11424 GO_RESPONSE_TO_COPPER_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COPPER_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. 33/42 Gene Ontology BP GO:0046688 0.000628605557330249 0.00287884021482052 4560 2219.27272727273 1430 5.71622945955419e-05 323 1.24157235730922 1.22605456444208 1 10.7746298380757 4328 959 1549 573 323 4031 4560 1430 696 1406 4557 1073 M13604 GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. 14/20 Gene Ontology BP GO:0060766 2.79742142242259e-06 4.24630185254455e-05 1585 1358.09090909091 1431 2.54311361773151e-07 12 1.19793504743408 1.56427715093278 1 17.8955921487745 1583 457 2193 400 12 2389 3060 439 181 2794 1431 1074 M12734 GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 26/45 Gene Ontology BP GO:0042036 0.0114600109463859 0.0229962809866686 3045 1814.09090909091 1432 0.001047286022975 686 1.22239537135725 -1.22690696412798 -1 6.83647056334127 3044 1678 1432 1249 1346 2284 3465 686 2181 1175 1415 1075 M16286 GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. 65/98 Gene Ontology BP GO:0003143 0.00577426225782821 0.0134540021460564 4640 2235.90909090909 1432 0.000526315789473684 214 1.22966502181844 -1.36390835463212 -1 7.8559449836116 4637 849 1396 214 3745 1432 4443 2902 1041 1119 2817 1076 M16337 GO_AXONAL_FASCICULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_FASCICULATION.html The collection of axons into a bundle of rods, known as a fascicle. 31/43 Gene Ontology BP GO:0007413 0.0260729401479442 0.0441475220190627 510 1927.54545454545 1432 0.00239883322267515 441 1.55203838061124 1.51578059124391 1 7.17992168790741 508 3439 985 3290 3839 908 441 1432 3096 1996 1269 1077 M10461 GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. 15/23 Gene Ontology BP GO:0003148 4.39863628675294e-05 0.00040528425034181 3935 1717.36363636364 1434 3.99884021334059e-06 11 1.29350816906407 -1.60680669950205 -1 14.9913040127518 3933 1127 1434 1074 117 2726 4520 11 1546 2365 38 1078 M13919 GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 268/336 Gene Ontology BP GO:0006650 0.00577426225782821 0.0134540021460564 3190 1509.27272727273 1434 0.000526315789473684 30 1.04564758926097 -1.04775534864983 -1 6.6787195360899 3188 658 1843 30 1434 481 3158 2530 1055 1685 540 1079 M10303 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. 132/145 Gene Ontology BP GO:0043624 0.00699761747606657 0.0156087795379376 150 1956.18181818182 1435 0.000638179515017237 148 0.753051923768382 -0.74354096529478 -1 4.64077069610447 148 1435 4122 1117 816 1012 1074 1952 3349 4338 2155 1080 M13394 GO_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 100/158 Gene Ontology BP GO:0006865 0.0133149786216771 0.0257393417227517 3100 2021.45454545455 1437 0.00121784126114825 37 1.19548186925925 1.15859784232854 1 6.48568584435335 3099 37 834 689 1437 3918 3387 2945 648 709 4533 1081 M15121 GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 38/55 Gene Ontology BP GO:0002756 0.00577426225782821 0.0134540021460564 2415 1849.72727272727 1437 0.000526315789473684 198 1.06449820795423 0.919297451928604 1 6.79931369784301 2413 227 2430 198 1427 1437 1319 3586 777 2151 4382 1082 M10067 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. 132/164 Gene Ontology BP GO:0050680 0.0017828379130813 0.0060428429119702 1345 1721.81818181818 1438 0.000162207666554206 377 1.26928588771224 1.27682559873858 1 9.61791056026624 1341 1438 561 1372 3957 2735 1686 2795 1508 377 1170 1083 M11967 GO_SYNAPTIC_VESICLE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYCLE.html A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. 85/129 Gene Ontology BP GO:0099504 0.038765812638778 0.0607945150684981 3105 1619.72727272727 1438 0.00358783993644367 71 1.236357421921 -1.39946882912018 -1 5.12999227534807 3104 71 1742 285 1438 2910 4528 1710 296 1174 559 1084 M15065 GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 25/32 Gene Ontology BP GO:0050995 0.0199648170291146 0.0354972463265076 1570 1386.90909090909 1438 0.00183166653591235 318 1.03026416159192 0.994282655952782 1 5.09615906223226 1570 318 1501 367 4395 1980 861 866 495 1438 1465 1085 M12844 GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that activates or increases the activity of a phosphoprotein phosphatase. 20/27 Gene Ontology BP GO:0032516 0.0214446676623653 0.0375261521748725 1480 1724.27272727273 1439 0.00196878173107381 420 1.00389002370083 1.24475933824002 1 4.88257523236473 1479 420 2745 1641 4490 1061 550 889 1439 2825 1428 1086 M14509 GO_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. 47/82 Gene Ontology BP GO:0046530 0.0112947991132011 0.0227241623439235 2535 1985 1439 0.00103210971385244 804 1.38531381297821 -1.44197664274709 -1 7.77352840886807 2534 909 804 1235 3242 1450 1439 3558 1399 1131 4134 1087 M15431 GO_STRIATUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATUM_DEVELOPMENT.html The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. 25/37 Gene Ontology BP GO:0021756 0.0030069404538369 0.00878298426346712 2130 1312.27272727273 1439 0.000273732563165409 328 1.51274884523994 -1.24234889353195 -1 10.6248381944771 2127 1676 994 1466 2156 459 2604 328 745 1439 441 1088 M10116 GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of hepatocyte proliferation. 11/16 Gene Ontology BP GO:2000345 0.000802603311033037 0.00340429645053484 870 1628.36363636364 1440 7.2990569650787e-05 29 1.09780251705175 0.901657990674162 1 9.25245059992813 868 533 2460 1839 4104 685 29 1369 1493 3092 1440 1089 M10130 GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 57/102 Gene Ontology BP GO:0018958 0.00126299002693653 0.00470511817080518 3520 2132.81818181818 1442 0.000114883243235444 397 1.57545499107584 1.36286692422302 1 12.5257980157288 3516 868 526 978 1442 4215 3533 2899 906 397 4181 1090 M15992 GO_NEUTRAL_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSPORT.html The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 25/38 Gene Ontology BP GO:0015804 0.013545012674265 0.0261189158613158 1445 1605.36363636364 1444 0.0012390120827958 323 1.36474291726979 1.35425422964005 1 7.3757995747744 1444 323 886 701 4343 2749 1643 2183 616 571 2200 1091 M10889 GO_COFACTOR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORT.html The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. 25/27 Gene Ontology BP GO:0051181 0.000386655610964191 0.00201467923607657 4425 2088.90909090909 1445 3.51566893999462e-05 103 1.33633604334757 -1.43326091853737 -1 12.3060500989462 4425 317 1445 275 268 3483 2977 4137 103 1433 4115 1092 M10140 GO_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 106/151 Gene Ontology BP GO:0016052 0.00661461651508971 0.0149117299635235 2830 1962.45454545455 1446 0.000603144402711725 467 1.08693871455198 1.25034829127217 1 6.77684732221926 2830 779 2464 1446 806 3304 4409 1028 467 1422 2632 1093 M12937 GO_ENSHEATHMENT_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENSHEATHMENT_OF_NEURONS.html The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. 107/139 Gene Ontology BP GO:0007272 0.0191965811786403 0.0344206906451688 1450 1451.18181818182 1446 0.00176056003446962 900 1.24059715260849 1.21701682471276 1 6.19547025365754 1359 1453 900 1717 1244 2134 1203 2150 1448 1446 909 1094 M15106 GO_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 115/138 Gene Ontology BP GO:0010827 0.0147876301496235 0.0279930199699749 470 1570.27272727273 1446 0.00135345208738025 395 0.988383456962246 1.13424664906802 1 5.23711492563907 470 1446 2195 1890 3918 479 395 767 2119 2667 927 1095 M10283 GO_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. 323/410 Gene Ontology BP GO:0006644 0.00577426225782821 0.0134540021460564 3935 1762.18181818182 1447 0.000526315789473684 15 1.08430036870139 -1.04471828582159 -1 6.92599521504218 3932 632 1514 15 1130 1524 3750 3776 788 876 1447 1096 M11044 GO_MALE_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DETERMINATION.html The specification of male sex of an individual organism. 8/17 Gene Ontology BP GO:0030238 0.0104563291933471 0.021376669480072 965 1701.36363636364 1447 0.00105058581764209 382 1.17153961186865 1.17153961186865 1 6.67864934060924 964 2417 4275 2423 945 382 416 1447 1790 2748 908 1097 M13182 GO_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT.html Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. 107/139 Gene Ontology BP GO:0008366 0.0191965811786403 0.0344206906451688 1450 1439.36363636364 1447 0.00176056003446962 901 1.24059715260849 1.21701682471276 1 6.19547025365754 1360 1454 901 1718 1245 2135 1204 2010 1449 1447 910 1098 M10034 GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. 16/22 Gene Ontology BP GO:0042053 0.0421707286608624 0.0649091632348636 3825 1818.90909090909 1448 0.00390922360654027 467 1.30495550179061 -1.25487689270082 -1 5.2883221188689 3824 467 1324 994 3580 516 906 2793 1717 2439 1448 1099 M14876 GO_UROGENITAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UROGENITAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. 343/437 Gene Ontology BP GO:0001655 2.38807632797906e-16 6.9448244713041e-14 735 1377.90909090909 1448 2.17097847998095e-17 11 1.34079079099242 1.32981151459435 1 60.308387863966 735 2479 11 2246 2837 589 1448 1856 2265 52 639 1100 M15930 GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. 16/22 Gene Ontology BP GO:0042069 0.0421707286608624 0.0649091632348636 3825 1814.45454545455 1449 0.00390922360654027 468 1.30495550179061 -1.25487689270082 -1 5.2883221188689 3825 468 1325 995 3581 517 907 2719 1718 2455 1449 1101 M16272 GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. 23/30 Gene Ontology BP GO:0032332 0.0249861536225831 0.0426018954950089 1450 1837.09090909091 1449 0.00229768415266692 658 1.43451319498696 1.35671558569401 1 6.71133755632264 1449 2773 1494 3706 3526 1089 1286 1224 846 658 2157 1102 M13940 GO_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell. 445/577 Gene Ontology BP GO:0040007 0.000232922436860856 0.00141671646890662 405 1514.81818181818 1450 2.11770091734868e-05 401 1.21613720095665 1.28084793442755 1 11.8340438356461 1353 1344 401 1801 3434 1134 1450 2151 1731 405 1459 1103 M16118 GO_IMMUNOLOGICAL_SYNAPSE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE_FORMATION.html The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 23/51 Gene Ontology BP GO:0001771 0.00347495146834189 0.009769757814015 3955 2136.90909090909 1450 0.000316404763975457 211 1.16669565074167 -1.26146653161997 -1 8.00743156823931 3951 1042 1450 211 628 3815 4007 2345 1189 1278 3590 1104 M10820 GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 424/544 Gene Ontology BP GO:0010769 1.16023166724971e-07 2.71284318980547e-06 995 1442.45454545455 1451 1.05475611676162e-08 150 1.20696074171387 1.2899987771579 1 22.9600065929612 992 1923 150 1286 2267 1451 1711 2321 2373 303 1090 1105 M10898 GO_OTIC_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OTIC_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. 29/42 Gene Ontology BP GO:0071599 0.00729966693323885 0.0161739763049335 50 1882.81818181818 1452 0.000665818232828702 47 1.34661622440925 1.35325074201846 1 8.23596264135288 47 3120 838 3194 1452 1143 1060 2084 4318 2239 1216 1106 M10963 GO_POSITIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LOCOMOTION.html Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. 517/658 Gene Ontology BP GO:0040017 1.23603931204806e-07 2.84325969642846e-06 215 1778.45454545455 1452 1.23603938079875e-08 77 1.22174367380955 1.30276519476493 1 23.1561745311737 215 2456 4271 2347 2389 1452 1417 572 3149 77 1218 1107 M16494 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 17/42 Gene Ontology BP GO:0003071 0.0137953316280279 0.0264808902909297 1455 1757.36363636364 1452 0.00126205489314921 625 1.43454931086634 1.35676319351219 1 7.7242987820968 1452 4522 1664 3550 1004 1639 703 1180 945 2047 625 1108 M15527 GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of JUN kinase activity. 87/121 Gene Ontology BP GO:0043507 0.0686794861979192 0.0975177446685743 1255 1637 1453 0.00644747007547874 434 1.15737101297762 1.00586832186503 1 3.98952375700584 1254 807 1988 434 3232 823 813 2427 2316 1453 2460 1109 M16620 GO_ALCOHOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 63/86 Gene Ontology BP GO:0046164 0.00130205106983754 0.0048231752957953 2345 1416.45454545455 1453 0.000118438392424854 360 1.35644110685636 1.28410777203379 1 10.7331137112942 2342 1534 597 1453 1243 1819 2206 666 1047 360 2314 1110 M12140 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. 133/160 Gene Ontology BP GO:2001237 0.031989672567707 0.0516833147422016 235 1700.72727272727 1454 0.00295132016916132 231 1.1110863197034 1.14260268800236 1 4.87699200460108 231 3652 989 3182 2029 427 657 1613 3834 1454 640 1111 M14730 GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by a ligand binding to an receptor located within a cell. 184/294 Gene Ontology BP GO:0030522 0.073075498850963 0.102628026343498 2825 2115 1454 0.00687472936563582 520 1.02758091416644 1.04031864185823 1 3.46300220066027 520 2962 3329 2823 4362 854 1307 1454 1440 2821 1393 1112 M10375 GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-alpha-amino acid across a membrane. 22/33 Gene Ontology BP GO:1902475 0.000296214325324096 0.00169441789232652 4040 2072.90909090909 1455 2.69322014538284e-05 224 1.37984290130895 -1.38163337944424 -1 13.0617384857594 4040 1060 1008 1455 224 2816 2174 4478 889 1194 3464 1113 M12003 GO_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MOTILITY.html Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. 851/1223 Gene Ontology BP GO:0048870 3.16094284551099e-14 5.48187926508039e-12 765 1756.09090909091 1456 3.16094284551104e-15 7 1.29957690630009 1.31206522543553 1 50.0243576239533 763 1300 4338 1706 2788 1361 1456 1103 2616 7 1879 1114 M14501 GO_CELLULAR_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. 145/207 Gene Ontology BP GO:0009267 0.00173749428264957 0.00592275523602084 690 1464.36363636364 1456 0.000158078911171559 33 1.33054756642284 1.2270243612935 1 10.1222872045449 689 2974 1456 1628 1455 33 208 2640 2526 2127 372 1115 M15497 GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. 52/80 Gene Ontology BP GO:0042149 0.000653021453406336 0.00295287543508229 2965 1602 1456 5.93832153639065e-05 20 1.25811758658324 1.35393106478195 1 10.8709205696457 432 3361 2262 3414 1456 92 350 313 2961 2961 20 1116 M10640 GO_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 440/596 Gene Ontology BP GO:1901652 0.000205277139294647 0.0012873468850097 1385 1549 1457 1.86632996139496e-05 312 1.13411658503902 1.16292308115945 1 11.1964490652869 1383 614 394 839 3964 1457 1640 1991 2438 312 2007 1117 M13497 GO_PROTEIN_ADP_RIBOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ADP_RIBOSYLATION.html The transfer, from NAD, of ADP-ribose to protein amino acids. 18/22 Gene Ontology BP GO:0006471 0.00204592824691144 0.00660631792704992 1905 1666.81818181818 1457 0.00018616667039125 273 0.8023825334328 -0.843243996105915 -1 5.96985043095384 1905 2307 3518 2414 520 404 1158 1457 783 3596 273 1118 M13591 GO_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 105/157 Gene Ontology BP GO:0006633 0.00111743778712857 0.00427937285885533 2155 1566.45454545455 1457 0.000101636887914728 444 1.32960213978515 1.23459464312656 1 10.7567036397209 2152 787 515 1457 2712 1931 998 705 2254 444 3276 1119 M12409 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 34/44 Gene Ontology BP GO:0033144 0.000288305456888596 0.00166231138897477 1460 1305.72727272727 1458 2.62130223324122e-05 220 1.01060116544959 1.30673863645636 1 9.59231019071574 1458 240 2592 394 220 1874 1741 806 1639 2617 782 1120 M12630 GO_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 104/139 Gene Ontology BP GO:0055076 0.0599509171452297 0.0869008154133189 1095 1574.27272727273 1458 0.00560452565202714 811 1.1446217767882 1.15354609336086 1 4.14136304805427 1094 1458 1789 2264 3623 811 1181 1783 837 820 1657 1121 M13553 GO_POSITIVE_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINESIS.html Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. 31/66 Gene Ontology BP GO:0032467 0.0393423247161446 0.0615120419705043 1060 1800.09090909091 1458 0.00364218298038558 565 1.08256708211078 -1.21052373151398 -1 4.47168628642586 1058 2217 3035 2529 3477 1458 768 1168 752 2774 565 1122 M16211 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. 65/115 Gene Ontology BP GO:0032755 0.00968387410650448 0.0201066783657141 735 1814.72727272727 1458 0.00088425134104183 629 1.14095850335295 1.24409289818668 1 6.60779809145632 733 2615 1458 2950 2892 1168 961 629 3498 2199 859 1123 M15095 GO_RESPIRATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_DEVELOPMENT.html The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. 227/307 Gene Ontology BP GO:0060541 5.19143827424962e-08 1.42092719353432e-06 1965 1663 1459 4.71948945159482e-09 126 1.4032674650343 1.37825827606956 1 28.0435295254094 1965 679 126 306 4307 2076 1893 3968 1459 134 1380 1124 M12109 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 19/21 Gene Ontology BP GO:0060213 3.62386753664476e-05 0.000345529828852624 530 1562.09090909091 1460 3.29447930074638e-06 82 0.755315589238951 0.7733802178577 1 8.92829769315132 528 1742 3432 2389 82 143 311 1460 2845 4023 228 1125 M15190 GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. 21/45 Gene Ontology BP GO:0042743 8.88444973942368e-07 1.55997526934107e-05 2910 1660.36363636364 1460 8.07677575209969e-08 5 1.3597915236604 -1.30363476161701 -1 22.3368006070616 2909 345 969 60 5 2081 2911 4411 276 1460 2837 1126 M15872 GO_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 143/188 Gene Ontology BP GO:0072006 1.85834400236504e-11 1.26277719749776e-09 215 1361.36363636364 1460 1.68940363852795e-12 48 1.33803487030143 1.28524867845506 1 40.6978381660781 214 2026 48 2276 2869 615 871 1497 2876 223 1460 1127 M16041 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 98/140 Gene Ontology BP GO:0090100 0.00424296089951011 0.011210958015571 1185 1925.72727272727 1460 0.000386469646906491 661 1.44915987817123 1.37371135074094 1 9.65258008517276 1184 2994 661 2065 3820 2317 1460 3702 1418 790 772 1128 M16522 GO_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. 187/270 Gene Ontology BP GO:0042594 0.0106955093336668 0.0217747243421654 1255 1784.54545454545 1460 0.000977078477399855 183 1.29662726807396 1.2130218173034 1 7.35735996997972 1251 2961 1460 3248 1131 183 582 3673 2705 1880 556 1129 M13006 GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS.html The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 166/326 Gene Ontology BP GO:0050953 0.00723168423590102 0.0160615879473258 360 2052.54545454545 1461 0.000659596880984789 357 1.11259120078552 1.21630493538713 1 6.81432190751232 357 3980 738 3918 2080 1173 1316 1461 4001 2484 1070 1130 M13808 GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. 77/130 Gene Ontology BP GO:0017158 0.0255995409253181 0.0434883767526488 2375 1654.09090909091 1461 0.00235476054509928 529 1.17300481192653 -1.24226965346936 -1 5.45006221270627 2374 821 1461 529 1208 1673 3717 2813 1329 1706 564 1131 M11696 GO_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that modulates the frequency, rate, or extent of leukocyte migration. 130/208 Gene Ontology BP GO:0002685 5.23679940002503e-09 1.81841997076988e-07 1335 1551.81818181818 1462 4.76072673862772e-10 99 1.38904287630907 1.54486485647308 1 31.9994843228318 1334 1437 99 1462 3421 1265 1925 1778 2449 221 1679 1132 M13299 GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. 17/26 Gene Ontology BP GO:0006688 0.000205566029564197 0.0012873468850097 2460 1584.81818181818 1463 1.86895672711761e-05 58 1.83574509782126 2.05320852371118 1 18.1298007946233 2457 1767 855 1727 2566 3531 1463 58 938 1049 1022 1133 M11137 GO_POLYOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 19/24 Gene Ontology BP GO:0046174 0.00118327344146432 0.00445811443168704 2870 1842.09090909091 1464 0.000107628213324728 108 0.891245944408806 0.815960288495676 1 7.15266264629754 2867 1102 3029 607 422 1464 1322 3370 108 3223 2749 1134 M11377 GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. 82/102 Gene Ontology BP GO:0008652 0.0316671052372527 0.0512316754520936 1025 1741.90909090909 1464 0.00292112077053859 816 1.13539616400561 -1.22831345165597 -1 4.99872757912303 1025 816 2424 1464 3410 1047 1800 1055 1403 2727 1990 1135 M12632 GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. 690/914 Gene Ontology BP GO:0007167 0.00359192724537916 0.00999246212739869 905 1605 1464 0.000359774636117972 455 1.14512479240286 1.18691358879557 1 7.82086224323795 904 1312 4380 1497 1944 808 1464 1067 2153 455 1671 1136 M15004 GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. 69/80 Gene Ontology BP GO:0043666 0.141391167641291 0.17981010136124 1095 1778.45454545455 1465 0.0137627638995697 114 0.95496737155687 1.08903846555703 1 2.4223567495825 1091 114 3407 669 4026 1465 1175 2184 570 2949 1913 1137 M15667 GO_MECHANOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of a mechanical stimulus. 13/22 Gene Ontology BP GO:0007638 0.000494392703288348 0.00241893716971681 1470 1337.45454545455 1466 4.49548945581089e-05 66 1.77695983056987 -1.85150903695767 -1 15.8846869445851 1466 2884 1551 1519 1838 662 1363 109 1147 2107 66 1138 M10107 GO_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 432/813 Gene Ontology BP GO:0050865 2.9101476110025e-09 1.09360499368976e-07 95 1708 1469 2.64558874077457e-10 92 1.258750547367 1.24109731976153 1 29.9473104208626 1086 1348 92 1469 4298 1506 1763 1325 3278 93 2530 1139 M11325 GO_MATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING.html The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. 24/48 Gene Ontology BP GO:0007618 0.000295647352076691 0.00169441789232652 3200 1766.54545454545 1469 2.68806445609008e-05 162 1.46324036098835 1.67415172887042 1 13.8518320919384 3200 354 1541 358 223 4347 4217 162 1469 2255 1306 1140 M12418 GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of mast cell degranulation. 10/16 Gene Ontology BP GO:0043306 0.00174449124544624 0.00593790619243697 345 1547.36363636364 1469 0.000158716007123325 62 0.916179324660511 0.916179324660511 1 6.96313897947964 342 1850 2751 1623 1469 867 62 271 3577 3617 592 1141 M12939 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. 10/16 Gene Ontology BP GO:0033008 0.00174449124544624 0.00593790619243697 345 1555.36363636364 1470 0.000158716007123325 63 0.916179324660511 0.916179324660511 1 6.96313897947964 343 1851 2752 1624 1470 868 63 346 3578 3621 593 1142 M15058 GO_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. 12/19 Gene Ontology BP GO:0046339 3.38104608786138e-05 0.000335904000263133 3375 1915.63636363636 1470 3.07372550019882e-06 74 1.55067630860841 -1.91493653810751 -1 18.4062352368415 3372 1818 1179 983 74 4400 3995 1551 855 1375 1470 1143 M12477 GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 96/128 Gene Ontology BP GO:0071300 2.68528424101559e-05 0.000281410530933458 1350 1698.45454545455 1471 2.44119728883515e-06 287 1.24548346909036 1.22230995384506 1 15.1089069116668 1346 1471 287 668 355 2102 2916 2903 3561 1032 2042 1144 M13085 GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION.html The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. 13/16 Gene Ontology BP GO:0071425 0.00877223213671134 0.0186324729082773 1475 1797.63636363636 1471 0.000800673350771906 202 1.65440082070099 1.88903720963052 1 9.77322242195667 1471 4549 2168 3985 1553 829 548 1279 1089 2101 202 1145 M12511 GO_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 95/116 Gene Ontology BP GO:0006029 7.83522918359533e-07 1.40971618572432e-05 390 1479.09090909091 1472 7.12293815826217e-08 199 1.39912263965237 1.40304101826226 1 23.1935952873355 387 1472 199 944 771 2849 2013 1930 3341 584 1780 1146 M11330 GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. 18/25 Gene Ontology BP GO:1902931 0.0156322689144855 0.0292351074192528 370 1820 1473 0.00143131480770916 313 1.22524610626775 1.11306081527887 1 6.4157422219365 366 3530 1398 3735 1113 601 313 2254 3642 1595 1473 1147 M11483 GO_CHONDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. 39/43 Gene Ontology BP GO:0002063 0.000259443897099975 0.00152231078588421 140 1358.45454545455 1473 2.35885907384668e-05 138 1.34222305954977 1.33152655201887 1 12.9188013732101 138 1597 505 1146 213 2072 2187 1623 2914 1473 1075 1148 M16136 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT.html The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 44/55 Gene Ontology BP GO:1901264 0.0134476673865917 0.0259742616645128 910 1482.81818181818 1474 0.00123005251488901 733 1.27264539474513 -1.04588599858769 -1 6.88783040892754 906 1584 2757 1474 1142 998 1508 733 959 2546 1704 1149 M10626 GO_RESPONSE_TO_IMMOBILIZATION_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IMMOBILIZATION_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. 17/28 Gene Ontology BP GO:0035902 0.0039303239754381 0.0106634387508533 2795 1565.45454545455 1475 0.000357942104923049 120 1.75257354913722 1.27822214364992 1 11.8060914680686 2791 1760 990 1475 2089 1297 120 724 194 2034 3746 1150 M13227 GO_LOCALIZATION_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_OF_CELL.html Any process in which a cell is transported to, and/or maintained in, a specific location. 851/1223 Gene Ontology BP GO:0051674 3.16094284551099e-14 5.48187926508039e-12 765 1797.81818181818 1476 3.16094284551104e-15 8 1.29957690630009 1.31206522543553 1 50.0243576239533 764 1301 4415 1707 2789 1362 1457 1476 2617 8 1880 1151 M16502 GO_CELLULAR_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 84/137 Gene Ontology BP GO:0035690 0.00407123648232218 0.0109310232846192 275 1502.09090909091 1476 0.000370799103196804 67 1.03302169945554 1.01639220560674 1 6.91648683892432 273 1499 1476 1900 4455 67 148 647 3283 2572 203 1152 M11916 GO_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CHEMOTAXIS.html The movement of a leukocyte in response to an external stimulus. 92/167 Gene Ontology BP GO:0030595 6.49241565923376e-09 2.09786180988991e-07 665 1564.72727272727 1477 5.90219607126685e-10 108 1.56442040290374 1.49007689407243 1 35.7089558774978 664 2081 108 1477 3125 1412 1997 1048 2855 126 2319 1153 M12115 GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY.html The formation or destruction of chromatin structures. 133/208 Gene Ontology BP GO:0006333 0.00638038444784915 0.01453153638563 305 1540.09090909091 1477 0.000581724014526768 105 1.13391606688051 -1.33288184460693 -1 7.11368674707736 301 2035 2952 2335 2494 105 632 1477 1387 2896 327 1154 M13171 GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS.html The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. 48/73 Gene Ontology BP GO:0001658 0.000365159292035613 0.00195321638000782 875 1453.36363636364 1478 3.32018105281077e-05 428 1.39916988752537 1.28791845770975 1 12.9495428699773 872 2152 428 1518 1902 1258 1097 2541 2159 582 1478 1155 M14006 GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. 6/15 Gene Ontology BP GO:0033004 0.000766992614661284 0.00330140299354205 2060 1492.90909090909 1478 7.67257468278077e-05 164 1.03781944043945 1.09661084869924 1 8.79361531025501 2059 1867 4464 1815 374 1478 553 164 399 2423 826 1156 M15813 GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of fatty acid derivative. 37/58 Gene Ontology BP GO:1901570 1.85304187437419e-05 0.000210297654669832 3775 1786.45454545455 1480 1.68459771143389e-06 123 1.70567642504394 -1.84874079774331 -1 21.4331619982536 3771 1612 274 958 123 3242 1321 1480 2360 213 4297 1157 M10409 GO_SINGLE_ORGANISM_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. 107/146 Gene Ontology BP GO:0044801 0.00577426225782821 0.0134540021460564 1900 1503.63636363636 1481 0.000526315789473684 32 1.08589272670036 -1.12918080759062 -1 6.93618209968621 1898 32 3142 128 2554 477 2322 1481 841 3413 252 1158 M10509 GO_RESPONSE_TO_ESTRADIOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTRADIOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 171/226 Gene Ontology BP GO:0032355 3.49335890048701e-06 5.17662387387453e-05 1820 1637.09090909091 1481 3.17578586142767e-07 234 1.23489581188259 1.2096379338123 1 18.0848202059162 1820 722 234 1338 1481 3106 2951 1087 2508 275 2486 1159 M11470 GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 23/27 Gene Ontology BP GO:0009067 0.0252008293090832 0.0429050343121713 890 1954 1481 0.00231765625766533 675 0.975277150773426 -1.08935156519646 -1 4.549130816193 886 3485 3600 2611 1204 1148 1481 1118 675 3477 1809 1160 M14240 GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. 91/152 Gene Ontology BP GO:0043255 0.0154871778484286 0.0290220855935314 630 1697.90909090909 1481 0.00141793532059544 630 1.04624172270104 1.04489966115378 1 5.4882267835485 630 1481 1614 2530 1835 1349 1159 775 3565 2627 1112 1161 M13699 GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 10/17 Gene Ontology BP GO:0010759 0.00283834076468469 0.00837463511609248 630 1867.36363636364 1482 0.000258364481070739 318 1.39058065785963 1.48826442318184 1 9.86422641368058 627 3594 1482 3000 1304 1649 1291 318 4192 2321 763 1162 M15490 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN.html The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. 17/41 Gene Ontology BP GO:0003081 0.0230659777312291 0.0398093450977036 2090 1700.27272727273 1483 0.00211922038058792 347 1.34670200147387 -1.19992228004884 -1 6.43543076933564 2090 1130 1441 347 1174 3486 2650 2172 650 1483 2080 1163 M10232 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. 20/23 Gene Ontology BP GO:0070230 0.029457658813848 0.0485448361749629 3305 2107.90909090909 1484 0.00271451349147151 862 1.48670092181827 -1.61486078769925 -1 6.6676094203038 3304 1723 1154 862 1260 2294 929 4159 1484 1386 4632 1164 M14930 GO_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_SYSTEM_PROCESS.html A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. 272/419 Gene Ontology BP GO:0003012 2.96939407731388e-05 0.000302332399162834 565 1638.45454545455 1484 2.6994855970118e-06 294 1.15867434428286 1.22022488973975 1 13.9317092731698 563 2496 294 2760 3247 1606 1484 925 3163 726 759 1165 M16622 GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE.html Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. 33/40 Gene Ontology BP GO:0043094 0.00692549985926559 0.0154850316411162 770 1943.54545454545 1484 0.000631581598620641 535 0.968804171456688 -0.958245651647316 -1 5.98487420100459 766 2707 3622 2645 1484 683 847 535 3539 3588 963 1166 M13392 GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. 12/14 Gene Ontology BP GO:2000052 0.0124174285032687 0.0243924242015775 1485 1203.18181818182 1485 0.00113527953630484 255 1.51934805918345 1.49400256260241 1 8.36685596702536 1485 1832 1711 1653 1600 720 314 1135 569 1961 255 1167 M16054 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the rate of production of a cytokine. 203/317 Gene Ontology BP GO:0001818 0.000660221533712841 0.00297672793066188 1255 1442.54545454545 1485 6.0038159085376e-05 315 1.27809235917839 1.38767506394336 1 11.0284164450377 1255 2519 558 1485 1987 1905 1801 828 1771 315 1444 1168 M10752 GO_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 47/52 Gene Ontology BP GO:0034405 0.00433033522727311 0.0113965213871616 1310 1649.27272727273 1486 0.000394443848769165 402 1.24707142410075 1.50802607836204 1 8.27462193858471 1308 1586 1511 2704 892 1296 1486 402 3872 1415 1670 1169 M12320 GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). 41/43 Gene Ontology BP GO:0006891 0.000613428499546599 0.0028224296228961 1885 1671.54545454545 1487 5.57817826646206e-05 320 0.687119960070266 -0.573890955298595 -1 5.97840222880282 1881 940 4058 1650 320 507 1487 1630 847 4284 783 1170 M15859 GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). 14/19 Gene Ontology BP GO:0048016 0.00222938027532164 0.00702360737453472 1140 1655.45454545455 1487 0.000202876603499477 76 0.954783702040327 1.00835099564672 1 7.01892966824218 1138 1812 2677 2406 1160 604 76 1487 2878 2801 1171 1171 M10373 GO_CARDIAC_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_DEVELOPMENT.html The progression of a cardiac septum over time, from its initial formation to the mature structure. 113/145 Gene Ontology BP GO:0003279 0.0219065533718408 0.0381193690498038 1495 1446.09090909091 1488 0.00201161623821242 25 1.26798047057342 1.29267539624438 1 6.14029553987065 1494 25 923 876 2304 1616 2085 3273 990 1488 833 1172 M11735 GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. 13/17 Gene Ontology BP GO:0060389 0.00577426225782821 0.0134540021460564 2505 1877.63636363636 1488 0.000526315789473684 42 1.23791073826966 1.54131384860247 1 7.90869578610088 2505 493 2206 203 1054 4615 4515 1488 42 1019 2514 1173 M10359 GO_NATURAL_KILLER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. 12/15 Gene Ontology BP GO:0001779 0.00357613905168682 0.00997905922511176 1285 1756.18181818182 1489 0.000325633217514749 358 0.953825865618015 0.968139265191999 1 6.51446704132877 1282 521 2959 1635 4053 1489 536 358 1332 3188 1965 1174 M16893 GO_EMBRYO_IMPLANTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_IMPLANTATION.html Attachment of the blastocyst to the uterine lining. 36/60 Gene Ontology BP GO:0007566 0.00495638495317275 0.0125269197105447 3440 2067.63636363636 1489 0.000451598777318102 252 1.73527765501092 -1.56069042287758 -1 11.2744903753188 3437 956 717 1489 731 4537 4214 2863 252 756 2792 1175 M10419 GO_ORGAN_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_REGENERATION.html The regrowth of a lost or destroyed organ. 92/128 Gene Ontology BP GO:0031100 0.0798927067984212 0.110571316101444 1545 1716.90909090909 1490 0.00754096793623118 55 1.15874775601983 1.20479429573547 1 3.77813656507719 1541 55 1393 316 3675 2499 1585 4305 1153 874 1490 1176 M15399 GO_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MIGRATION.html The movement of a lymphocyte within or between different tissues and organs of the body. 33/74 Gene Ontology BP GO:0072676 0.00133067302795265 0.00489069636576909 505 1544.54545454545 1490 0.000121043506324889 503 1.56601729522157 1.55257145969523 1 12.3607486003429 503 2209 530 1490 2871 669 1206 2119 2580 1059 1754 1177 M16064 GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. 14/29 Gene Ontology BP GO:0045346 0.0657044737763343 0.0936364215869168 1990 1833.81818181818 1490 0.0061593603032238 626 1.23802404710726 0.941423081029824 1 4.34294301267656 1988 1157 2388 1421 2112 1490 866 4499 626 2803 822 1178 M14112 GO_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. 10/25 Gene Ontology BP GO:0019433 0.0203143320778513 0.0360086046317113 2465 1778.09090909091 1491 0.0018640337803509 539 1.53852349527494 1.34984056732469 1 7.58282909602207 2461 539 910 1250 1491 2789 1432 2799 2074 1085 2729 1179 M16602 GO_NEURAL_CREST_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. 82/108 Gene Ontology BP GO:0014033 5.666314888823e-09 1.8832402269781e-07 2050 1791.54545454545 1491 5.15119536674288e-10 104 1.48879568322192 1.64386122548585 1 34.2208344854239 2048 1491 104 1471 1365 4123 3698 1115 2109 189 1994 1180 M11039 GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of vasculature development. 141/200 Gene Ontology BP GO:1904018 3.54133145479089e-06 5.21449849972848e-05 375 1638.18181818182 1492 3.21939741388293e-07 235 1.35167455084344 1.37954365080523 1 19.7814007621488 372 2029 235 2874 2230 1492 1393 2585 3003 449 1358 1181 M14873 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. 32/43 Gene Ontology BP GO:0048873 0.0252420162234826 0.0429594372669585 2480 1869.63636363636 1492 0.00232148849191798 251 1.40528203284978 1.89080005264383 1 6.55692393312219 2479 1635 1492 1362 2903 3608 3787 952 251 995 1102 1182 M12106 GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY.html The disaggregation of a beta-catenin destruction complex into its constituent components. 29/34 Gene Ontology BP GO:1904886 0.0606798660079641 0.087847982742706 1495 1555.81818181818 1495 0.00567464956007358 309 1.11369247665166 0.92490159783817 1 4.01124321374192 1495 309 2468 1148 1521 1244 1170 2189 474 3050 2046 1183 M12722 GO_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. 422/660 Gene Ontology BP GO:0050708 2.7793056548932e-06 4.24003580728461e-05 1000 1662.72727272727 1496 2.52664469641265e-07 229 1.20142578928678 1.21520943961734 1 17.9504047357363 998 2469 229 1496 3632 1449 1710 1486 2208 250 2363 1184 M10685 GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. 94/156 Gene Ontology BP GO:0045833 0.0132284882655677 0.0256272400153365 1500 1432.81818181818 1497 0.00120988241815816 58 1.13009537001467 1.05983600197976 1 6.13769422904696 1497 58 831 357 1995 1161 1524 2958 1565 1337 2478 1185 M12252 GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of muscle contraction. 40/61 Gene Ontology BP GO:0045933 0.00219206298509527 0.00692912300927192 810 1848.63636363636 1498 0.00019947729012276 584 1.32329081734142 1.36320145941857 1 9.75867380391223 808 3074 584 3281 3472 1498 965 923 2968 751 2011 1186 M10860 GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. 35/40 Gene Ontology BP GO:0035872 0.00768138214755555 0.0167879150458318 225 1931.63636363636 1499 0.000700757619670769 193 0.828996247675613 0.812443547831156 1 5.02021926479025 223 3416 3572 2886 1499 469 193 966 3461 3399 1164 1187 M12959 GO_REGULATION_OF_CHEMOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_SECRETION.html Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell. 13/20 Gene Ontology BP GO:0090196 0.0213614919813279 0.0374147133234673 670 1596.18181818182 1499 0.00196107011073585 322 1.63734281704269 1.66764375195607 1 7.97742999813547 668 2380 1121 2794 2454 322 605 2365 2666 1499 684 1188 M15275 GO_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_MOVEMENT.html A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules. 217/278 Gene Ontology BP GO:0007018 0.00258778726323187 0.00782159822858816 1380 1878.63636363636 1501 0.000235530564904223 44 1.0431726805618 -1.06682011956217 -1 7.50300946018796 1380 2512 3344 1481 3511 44 1243 1909 1501 3458 282 1189 M10060 GO_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSPORT.html The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 80/175 Gene Ontology BP GO:0006813 1.59085010039304e-08 4.82328922603327e-07 1725 1429.36363636364 1502 1.44622737445154e-09 113 1.5143258407135 -1.61969571457897 -1 32.6931979571629 1725 1502 113 2735 3065 493 2019 437 2413 534 687 1190 M14185 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 111/165 Gene Ontology BP GO:0002065 0.00184249358403804 0.00618105453967485 2535 1875.09090909091 1502 0.000167639861702522 474 1.34013582652196 1.25596052564434 1 10.1103657596335 2535 774 559 640 3208 1502 1368 4281 2230 474 3055 1191 M14962 GO_ENDODERM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_FORMATION.html The formation of the endoderm during gastrulation. 63/84 Gene Ontology BP GO:0001706 3.54744369250298e-05 0.000341744420315039 120 1675.63636363636 1502 3.22500081401447e-06 120 1.4908404102284 1.5334124148013 1 17.6574247331395 120 3033 301 2647 2050 1379 1502 1367 3698 823 1512 1192 M16528 GO_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCONEOGENESIS.html Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. 46/84 Gene Ontology BP GO:0006111 0.00929719924676042 0.0195392358153461 835 1693.90909090909 1503 0.00084879302236183 261 1.08927941017547 0.992537415946054 1 6.35432045249067 834 2159 2572 2322 3754 965 341 608 1503 3314 261 1193 M11917 GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. 19/26 Gene Ontology BP GO:0051156 8.55520692735271e-05 0.000661252123471299 1505 1209.45454545455 1504 7.77776330400052e-06 129 1.03730651574387 -1.11170933795919 -1 11.2658939543348 1504 1085 2663 478 129 1624 2152 278 137 1734 1520 1194 M13721 GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. 184/242 Gene Ontology BP GO:0045017 0.00577426225782821 0.0134540021460564 2115 1273.54545454545 1504 0.000526315789473684 48 1.05753436609528 -1.1326645424542 -1 6.75476350640225 2111 704 2538 48 1673 249 2235 1504 506 1968 473 1195 M15151 GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 18/23 Gene Ontology BP GO:0042776 0.00257913657510325 0.00781297036715849 55 1808.81818181818 1504 0.000234742287142573 54 0.49016721430493 -0.49016721430493 -1 3.52067373420541 54 1735 3710 2566 708 318 89 1205 3412 4596 1504 1196 M10827 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. 77/123 Gene Ontology BP GO:1903428 0.0310903413011915 0.0505893509901608 1425 1577.09090909091 1505 0.0028671457654995 697 1.1510056692458 1.33992155736211 1 5.08915991332484 1423 2099 1105 1658 1408 1809 2004 1062 1505 697 2578 1197 M11824 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of extracellular matrix assembly. 16/16 Gene Ontology BP GO:1901201 0.00213068669839187 0.0068044510690579 1125 1783.45454545455 1505 0.000193886641625398 279 1.38835110332001 1.46540697148736 1 10.2764169097118 1124 2839 2731 3850 1721 1505 1444 279 766 1892 1467 1198 M10512 GO_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 148/204 Gene Ontology BP GO:0051216 3.47940697973102e-12 2.65404601257188e-10 495 1220.27272727273 1506 3.16309725430593e-13 42 1.46526349322534 1.58467658122638 1 47.9622884139138 491 2016 42 1547 1720 2059 1506 516 2868 233 425 1199 M12509 GO_PROTEIN_TRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRIMERIZATION.html The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. 48/65 Gene Ontology BP GO:0070206 0.0213649029229427 0.0374147133234673 90 1936.72727272727 1506 0.00196138634394097 87 1.30895209450122 1.20232397506106 1 6.37531251999523 87 3056 1237 3835 1506 1220 682 2450 3830 2462 939 1200 M13749 GO_POSITIVE_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_URINE_VOLUME.html Any process that increases the amount of urine excreted from the body over a unit of time. 12/17 Gene Ontology BP GO:0035810 0.00533607338752777 0.0131997604849371 1085 1790.72727272727 1508 0.000486278189923305 457 1.1021645784852 1.22751325995915 1 7.07150052113763 1085 534 1717 3475 2946 1215 756 457 4042 1963 1508 1201 M16052 GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Ras protein signal transduction. 215/239 Gene Ontology BP GO:0046578 0.0181385220307068 0.0328910923651124 640 1565.72727272727 1508 0.00166271086293171 282 1.10886141722976 1.09257932330581 1 5.61129932494161 637 1972 1338 2321 1508 282 777 1969 3181 1290 1948 1202 M16513 GO_POLYOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 31/43 Gene Ontology BP GO:0046173 0.0104426623751004 0.021376669480072 1710 1469.81818181818 1508 0.000953869282628105 273 1.02761925615772 -1.2535112085925 -1 5.85688611223723 1707 273 2333 1508 939 1364 2284 653 1542 3179 386 1203 M10838 GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). 15/33 Gene Ontology BP GO:0042744 7.90749891412096e-07 1.40971618572432e-05 1510 1371.63636363636 1509 7.18863796029884e-08 4 1.49746393573302 -1.43002265183893 -1 24.8245722610422 1509 448 1070 69 4 1536 2342 4529 282 1758 1541 1204 M12549 GO_PROTEIN_HETEROTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTRIMERIZATION.html The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. 27/31 Gene Ontology BP GO:0070208 0.000862313830470199 0.00358245201176592 20 1945 1509 7.84229099368379e-05 18 1.23023593125991 1.11936289820915 1 10.2767283034886 18 3472 889 3447 1509 713 558 2366 4460 2935 1028 1205 M14858 GO_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a second cell of the identical type via adhesion molecules. 75/108 Gene Ontology BP GO:0034109 0.0175054985220569 0.0319800096675032 1510 1406.18181818182 1509 0.00160421475283941 476 1.15329070582801 1.07595966739387 1 5.88466114166607 476 1509 1183 2327 1618 1550 996 813 2547 940 1509 1206 M16757 GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 68/105 Gene Ontology BP GO:0002088 0.0237839288301608 0.0408665512727985 1620 1795.54545454545 1509 0.00218591038112117 402 1.21383200106065 1.19226449977854 1 5.7521986307831 1619 2606 2074 1411 4095 1504 1431 2195 905 1509 402 1207 M10188 GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 29/42 Gene Ontology BP GO:0052646 0.00577426225782821 0.0134540021460564 3060 1917.81818181818 1510 0.000526315789473684 38 1.35796491348436 -1.55199036871557 -1 8.67672535905907 3059 289 1306 38 3819 2347 3385 4387 368 588 1510 1208 M10779 GO_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. 12/21 Gene Ontology BP GO:0043501 0.000429177213502638 0.0021848594906212 935 1838.63636363636 1512 3.90237236821315e-05 17 1.29558544966171 1.17860327783329 1 11.7744631943745 931 3246 2008 3332 1702 1219 17 1512 4156 1367 735 1209 M10810 GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 984/1413 Gene Ontology BP GO:0045937 9.09856393998471e-08 2.22819042172362e-06 1205 1725.90909090909 1513 9.0985643125121e-09 73 1.23259169993787 1.24849412591524 1 23.8080054288072 1204 1285 4264 462 3214 986 1513 1973 2218 73 1793 1210 M12940 GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 984/1413 Gene Ontology BP GO:0010562 9.09856393998471e-08 2.22819042172362e-06 1205 1769.36363636364 1514 9.0985643125121e-09 74 1.23259169993787 1.24849412591524 1 23.8080054288072 1205 1286 4396 463 3215 987 1514 2310 2219 74 1794 1211 M10993 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte migration. 19/39 Gene Ontology BP GO:2000403 0.00146667973528165 0.00523934335578733 2325 1570.45454545455 1515 0.000133423494915991 219 1.66411616373798 -1.66003167689348 -1 12.9655699522476 2324 2299 755 1515 1379 1518 2278 219 3239 884 865 1212 M11843 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). 446/684 Gene Ontology BP GO:0032787 4.47318711614748e-06 6.38458271516388e-05 4610 2240.90909090909 1515 4.06654201032413e-07 8 1.18050677847806 -1.07360455977243 -1 16.9202023035483 4608 608 239 8 1494 3105 4509 4470 1515 246 3848 1213 M10260 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. 108/134 Gene Ontology BP GO:0002504 0.0987139810877097 0.132444104383251 1520 1438.72727272727 1516 0.00940392444032056 28 1.12751368672174 -1.15517767934652 -1 3.37382242487318 1516 28 2533 279 1950 1692 1377 1772 420 3251 1008 1214 M14096 GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. 88/106 Gene Ontology BP GO:0008286 0.0197323064697861 0.0351375514749004 1125 1811.90909090909 1516 0.0018101404392054 811 0.949653679683906 0.992500923243225 1 4.71094958520356 1123 811 3172 2817 2233 1311 1008 862 2122 2956 1516 1215 M11780 GO_DORSAL_VENTRAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_PATTERN_FORMATION.html The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 73/135 Gene Ontology BP GO:0009953 0.0271174720421006 0.0456008664300304 1605 2020.63636363636 1517 0.00249614633141995 434 1.18857743215516 -1.23097823717747 -1 5.43884643937041 3843 1517 1442 1602 1294 3719 4035 1453 1601 1287 434 1216 M12096 GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 109/202 Gene Ontology BP GO:0030799 1.62856182230756e-06 2.61299936524037e-05 1550 1592.81818181818 1517 1.4805118435095e-07 220 1.302396682314 1.23165111311757 1 20.3960172695634 1546 776 220 766 3022 1517 1894 2240 3528 593 1419 1217 M14205 GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a myeloid leukocyte. 44/91 Gene Ontology BP GO:0002444 0.0547705892081465 0.0805969486355172 1520 1629.36363636364 1517 0.00510760416825691 220 1.27331086587792 1.26548402607318 1 4.75055111425305 774 220 1782 2143 4252 1520 716 1323 2299 1517 1377 1218 M15120 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. 108/134 Gene Ontology BP GO:0002495 0.0937417313837284 0.12664932524056 1520 1421.18181818182 1517 0.00890835147799919 29 1.12751368672174 -1.15517767934652 -1 3.44872236399593 1517 29 2534 280 1951 1693 1378 1569 421 3252 1009 1219 M15854 GO_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_MEDIATED_ENDOCYTOSIS.html An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. 204/399 Gene Ontology BP GO:0006898 2.01391353350897e-06 3.18732641884941e-05 2745 1865.81818181818 1517 1.83083216098044e-07 222 1.33924416911873 1.42479506292391 1 20.5782718439473 2744 690 222 271 1125 4262 3515 2208 1517 477 3493 1220 M16556 GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/22 Gene Ontology BP GO:0051957 1.55207830071374e-05 0.000183294932315254 1520 1539 1518 1.4109902278011e-06 6 1.89428821680399 2.20599901678633 1 24.1909377124658 965 3231 1518 1520 1065 1901 2549 6 1398 2588 188 1221 M15023 GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of glia cell differentiation. 66/97 Gene Ontology BP GO:0045685 0.0217089348729088 0.0378320876268332 670 1737.63636363636 1519 0.00199328717932285 328 1.22423736346102 1.18793650849336 1 5.94184961088244 666 3702 1831 3437 1393 328 482 1519 3257 1970 529 1222 M15212 GO_MEMBRANE_PROTEIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. 44/63 Gene Ontology BP GO:0033619 0.00214997900389111 0.00684726372697148 4645 1729.18181818182 1519 0.000195643907124716 205 1.3200758735132 1.00455301433809 1 9.75823309646141 4645 919 2176 205 532 2070 3322 2597 593 1519 443 1223 M12748 GO_REGULATION_OF_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 304/457 Gene Ontology BP GO:0090087 0.000643822461177537 0.00292751268067582 2020 1690.63636363636 1520 5.85464500767553e-05 465 1.18439780611455 1.17424861334939 1 10.2484813191046 790 1369 465 2020 4134 1632 1520 2018 2841 497 1311 1224 M16020 GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. 17/28 Gene Ontology BP GO:0036151 0.00577426225782821 0.0134540021460564 3910 2145.81818181818 1522 0.000526315789473684 71 1.26502762704978 -1.3305646899433 -1 8.08217223931466 3906 437 1349 71 3568 4232 4346 1522 1061 1052 2060 1225 M16363 GO_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of JUN kinase activity. 119/166 Gene Ontology BP GO:0043506 0.05814555102497 0.0846530816392946 1420 1705.54545454545 1522 0.00543106443471182 738 1.17901390378217 1.11663930202284 1 4.31199476959117 1417 1447 2071 1144 2287 1444 738 2319 2813 1522 1559 1226 M11144 GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. 21/23 Gene Ontology BP GO:0061099 0.0228725320801811 0.0395341351296742 1655 1681.27272727273 1523 0.0021012589624707 169 1.01005812616318 -0.927408164255427 -1 4.83446294598727 1653 2285 3038 1523 1273 2341 1425 916 169 2426 1445 1227 M13075 GO_SOMITOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITOGENESIS.html The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 70/100 Gene Ontology BP GO:0001756 0.0120431565804535 0.0238251732860758 590 1466.18181818182 1523 0.00110087204416716 268 1.24881052968666 1.18959567446184 1 6.91877245305944 586 1523 1823 3378 2587 584 268 1294 1605 2192 288 1228 M16937 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. 220/261 Gene Ontology BP GO:1903322 0.0967676264420579 0.130245003452322 1260 1864 1523 0.00920964030876944 362 0.841862703902439 -0.823004735748131 -1 2.53730656113802 1258 677 4008 362 2584 966 2077 1589 1523 4040 1420 1229 M10421 GO_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a gland are generated and organized. 142/166 Gene Ontology BP GO:0022612 1.06579373346046e-07 2.54314781630335e-06 1525 1438.45454545455 1525 9.68903440993659e-09 136 1.37080591111832 1.33604960939311 1 26.2097564654488 1525 1431 147 1875 1549 947 783 3511 1974 136 1945 1230 M10795 GO_MALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. 13/30 Gene Ontology BP GO:0030539 0.0153080758447792 0.0287675593318892 3615 2091.09090909091 1525 0.00140142200676329 193 1.57165220642457 1.16677385740634 1 8.27026192589434 3614 1174 1525 739 1030 2924 4544 1831 193 1495 3933 1231 M13784 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell migration. 83/93 Gene Ontology BP GO:0014910 0.00434115634915352 0.01140564680554 555 1562.63636363636 1525 0.000395431480727716 416 1.26951461719743 1.408975054412 1 8.42222110953229 555 2095 665 2562 1525 1641 1729 416 3490 1095 1416 1232 M14860 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. 47/61 Gene Ontology BP GO:0030857 0.00379458168525801 0.010384592062893 3085 2067.72727272727 1525 0.000345558405924065 644 1.54065334345096 1.23331967010126 1 10.4378327421744 3082 3046 644 2655 3574 793 922 1075 1525 875 4554 1233 M14328 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. 124/154 Gene Ontology BP GO:0048660 2.89891221298924e-05 0.000297106575485439 1530 1704.90909090909 1526 2.63540946572183e-06 285 1.26738075841667 1.22281674535599 1 15.2725897915172 1526 2044 293 2849 4404 1594 1346 1402 1736 285 1275 1234 M13989 GO_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSPORT.html The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 176/297 Gene Ontology BP GO:0006816 0.000506972745677304 0.00244450174677357 1530 1852.18181818182 1527 4.6099055570475e-05 450 1.13474418406931 1.15863508658448 1 10.1221940428864 1527 721 450 2481 3603 1147 1479 2624 3143 1210 1989 1235 M14319 GO_OLFACTORY_LOBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_LOBE_DEVELOPMENT.html The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. 44/61 Gene Ontology BP GO:0021988 0.0512681470783437 0.0761899355974235 1175 2214.90909090909 1527 0.0047730343144108 868 1.34952451085738 1.35663300495732 1 5.14820948312786 1174 3390 1101 4263 3703 1527 1873 1491 3752 1222 868 1236 M16435 GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity. 26/40 Gene Ontology BP GO:0035587 0.00599701472805234 0.0138209638056484 1430 1885.18181818182 1527 0.000546674976788051 337 1.19814261791482 1.3029997351675 1 7.60641106953166 1430 337 789 3196 3638 2237 1010 490 4043 1527 2040 1237 M11892 GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. 290/400 Gene Ontology BP GO:1901565 0.000868909576696052 0.0036002103832295 3810 2065.27272727273 1528 7.90229954678294e-05 491 1.28293085613574 -1.18461410816753 -1 10.7079505257859 3809 655 491 687 3243 1204 3143 4139 1528 552 3267 1238 M12541 GO_ARACHIDONIC_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_SECRETION.html The controlled release of arachidonic acid from a cell or a tissue. 8/14 Gene Ontology BP GO:0050482 7.9815031011021e-05 0.000628067476603573 1530 1493.27272727273 1528 7.98178978535686e-06 30 1.53787070011335 1.11422107274287 1 16.8250967203821 1528 1861 4373 2294 474 936 919 30 1804 2018 189 1239 M15690 GO_REGULATION_OF_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H4_ACETYLATION.html Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. 14/16 Gene Ontology BP GO:0090239 0.0239599413597727 0.0411082622223534 1270 1626.45454545455 1529 0.00220226687342514 222 1.21831316074298 1.39497035305673 1 5.76280565731376 1267 495 3105 448 3367 1561 1529 934 222 2799 2164 1240 M15723 GO_ARACHIDONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONATE_TRANSPORT.html The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/14 Gene Ontology BP GO:1903963 9.97392384093672e-05 0.000745168890648425 1530 1512.81818181818 1529 9.97437152542193e-06 35 1.53787070011335 1.11422107274287 1 16.4347060749569 1529 1862 4569 2295 475 937 920 35 1805 2024 190 1241 M10875 GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. 30/37 Gene Ontology BP GO:0032793 0.00513598537809247 0.0128620774834576 430 1635.72727272727 1530 0.000468001351847842 429 1.17233076747244 1.24403373335444 1 7.56747770476604 429 3442 2292 2468 1530 872 753 443 1655 2719 1390 1242 M13813 GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. 11/19 Gene Ontology BP GO:0060575 0.0017008422901527 0.00584060455799298 115 1961.36363636364 1530 0.000154741695777444 113 1.19973864656868 -1.30952057278034 -1 9.15097736780492 3564 1203 1933 115 486 3148 3704 4546 113 1233 1530 1243 M11726 GO_PEPTIDYL_ARGININE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_MODIFICATION.html The modification of peptidyl-arginine. 15/19 Gene Ontology BP GO:0018195 0.0306073213593033 0.0499529520465936 1535 1875.27272727273 1531 0.0028219660256384 486 0.823690931755081 -0.896725014010078 -1 3.65439200537313 1531 1794 3067 2100 2951 1395 486 1359 1378 3438 1129 1244 M12427 GO_LEYDIG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEYDIG_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. 8/13 Gene Ontology BP GO:0033327 0.0030409335306799 0.00886002737523706 1450 2095.90909090909 1531 0.000304510283722382 386 1.02919343360734 1.02919343360734 1 7.2118169527567 1446 2916 4368 3365 614 1531 502 3159 386 3489 1279 1245 M16771 GO_INTESTINAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_ABSORPTION.html Any process in which nutrients are taken up from the contents of the intestine. 37/58 Gene Ontology BP GO:0050892 0.00057033679591394 0.00267968427588706 1145 1514.36363636364 1532 5.1862245999155e-05 456 1.59250239042832 1.4962291037561 1 13.992603724756 1141 2689 456 2016 2363 871 616 1532 2083 613 2278 1246 M10607 GO_INTERMEDIATE_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_ORGANIZATION.html Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 20/32 Gene Ontology BP GO:0045109 0.001676272287813 0.00579902970646384 845 1959.54545454545 1533 0.000152504624916999 479 2.22514702987176 -2.67281595621579 -1 17.0049707926331 844 2298 1146 3470 479 833 1533 4513 3685 1838 916 1247 M13531 GO_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SIZE.html Any process that modulates the size of a cell. 209/258 Gene Ontology BP GO:0008361 0.000326035715677769 0.00181247811833771 1275 1413.27272727273 1533 2.96440039602854e-05 286 1.21142466825752 1.25275302214236 1 11.3450154109262 1274 1386 421 749 3096 1533 1899 1605 1705 286 1592 1248 M12472 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of smooth muscle cell proliferation. 83/99 Gene Ontology BP GO:0048661 0.00776230280998106 0.0169012611019382 1120 1807.27272727273 1535 0.000708166068083415 614 1.18341956448942 1.15630710624019 1 7.15926376337651 1118 2093 753 2926 4454 1535 1157 850 2440 614 1940 1249 M14028 GO_NEURON_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_CELL_CELL_ADHESION.html The attachment of a neuron to another cell via adhesion molecules. 13/22 Gene Ontology BP GO:0007158 0.0076273883454079 0.0166881610669546 2845 1761.90909090909 1535 0.000695814684629304 479 1.74936958628146 -2.12363091834957 -1 10.6211166891292 2841 2352 751 967 3548 2150 1411 2324 479 1023 1535 1250 M16849 GO_RESPONSE_TO_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. 94/150 Gene Ontology BP GO:0014823 0.0179384636836657 0.0326045591875377 1080 1673.09090909091 1536 0.00164422026975901 862 1.26484164892027 1.39975759733809 1 6.41855664618213 1080 2077 893 1899 2762 2544 1430 1830 1491 1536 862 1251 M13838 GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. 45/140 Gene Ontology BP GO:0050829 0.0162898606227082 0.0302460979558903 925 2077.90909090909 1537 0.00149197672433676 787 1.26947344078432 1.29346060411619 1 6.5836316913213 922 3743 916 4205 1741 1523 1537 787 4276 1930 1277 1252 M15503 GO_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_CHEMOTAXIS.html The movement of a monocyte in response to an external stimulus. 21/54 Gene Ontology BP GO:0002548 4.14265148493269e-05 0.000386287722633102 1540 1720.72727272727 1537 3.76611772189649e-06 306 1.95883335998738 1.65103045481654 1 22.8473007045121 1537 2793 306 2005 967 1941 2018 1416 3948 780 1217 1253 M10871 GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. 150/179 Gene Ontology BP GO:0035567 0.00577426225782821 0.0134540021460564 1540 1428.90909090909 1538 0.000526315789473684 109 1.02609419128723 -0.933876882580061 -1 6.55362944348126 1538 724 2600 109 2018 632 1671 1794 606 2676 1350 1254 M10955 GO_GLUTAMATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. 23/33 Gene Ontology BP GO:0006536 0.0231094454660824 0.0398695772167896 875 1626.45454545455 1539 0.00212325680227535 455 1.38411861124372 -1.28615763942365 -1 6.61142110346076 875 1697 1539 1985 4511 455 963 920 2090 2153 703 1255 M13921 GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. 64/112 Gene Ontology BP GO:0031644 4.74178622642177e-06 6.70624052022508e-05 820 1717.09090909091 1539 4.31072404245139e-07 166 1.62263832685356 1.60896359004782 1 23.1428418653171 819 1539 241 2812 2849 2359 2867 166 3310 864 1062 1256 M10222 GO_SULFUR_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 324/421 Gene Ontology BP GO:0006790 4.89963784806457e-06 6.82575296618097e-05 2885 1386.63636363636 1540 4.45422614556527e-07 4 1.17343636768147 -1.1385730879355 -1 16.7023802429208 2881 631 244 4 787 1540 3110 1712 1568 331 2445 1257 M12650 GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. 11/11 Gene Ontology BP GO:0070129 0.0116902945892559 0.0232960178049697 440 1812.72727272727 1541 0.00106844365626095 251 0.652164318869918 -0.652164318869918 -1 3.6298345711785 437 2896 3599 2620 1659 251 261 755 1541 4517 1404 1258 M13868 GO_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 46/71 Gene Ontology BP GO:0098900 0.0100736777255619 0.0207493680642053 3360 1828.45454545455 1541 0.000920009310590234 639 1.1764127861517 -1.25095631380148 -1 6.75850087410414 3358 907 981 1541 3020 649 2683 639 3139 1999 1197 1259 M13376 GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of cardiac muscle tissue are generated and organized. 72/112 Gene Ontology BP GO:0055008 3.04801188244261e-05 0.000307644236204023 255 1382.09090909091 1543 2.77095828385956e-06 196 1.3627121779224 1.3957609961003 1 16.3516627889203 254 2111 296 2185 2254 1543 1551 1178 3087 548 196 1260 M14191 GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 183/238 Gene Ontology BP GO:0031345 0.000801332800429129 0.00340200868649337 1545 1559.36363636364 1543 7.28749844149346e-05 481 1.3067942205466 1.45013624677392 1 11.0171995316999 1543 1992 481 1251 3330 1617 1717 2395 1397 650 780 1261 M16268 GO_NEGATIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DEATH.html Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. 210/276 Gene Ontology BP GO:1901215 0.0903097906940297 0.122976721129447 1545 1614.90909090909 1544 0.00856773746354443 1045 1.12857793301318 1.15129752757205 1 3.50129977318633 1234 1389 2233 1940 1761 1106 1045 1544 1544 1558 2410 1262 M13680 GO_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTION.html Self-propelled movement of a cell or organism from one location to another. 1068/1674 Gene Ontology BP GO:0040011 8.41349702828196e-18 3.55890924296327e-15 725 1753.27272727273 1545 8.41349702828198e-19 4 1.29534462279492 1.30837619161785 1 63.9784383105511 724 1883 4443 1702 2657 980 1499 1276 2573 4 1545 1263 M15575 GO_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. 59/74 Gene Ontology BP GO:0060350 0.0011443362602987 0.00434750735150862 1440 2072.90909090909 1545 0.00010408472035241 519 1.24754995050092 1.19619013293382 1 10.0629688397949 1439 1545 519 1141 768 4054 2941 2311 3525 1534 3025 1264 M10231 GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 10/16 Gene Ontology BP GO:0072216 0.000781187655310591 0.00334162763686406 455 1462.63636363636 1546 7.10422892304859e-05 359 1.1193188356089 1.1336099770477 1 9.46488287736829 453 2899 1627 2546 359 1546 443 861 3155 1643 557 1265 M10171 GO_OLIGOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 56/71 Gene Ontology BP GO:0009311 0.00282715015448235 0.00835856302424057 2265 1595.18181818182 1547 0.000257344525919851 315 1.33522826931318 1.57952571199392 1 9.4749626562544 2261 1547 1112 935 1849 3084 2513 315 330 1127 2474 1266 M10534 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS.html Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 16/17 Gene Ontology BP GO:0010561 0.000883496977644967 0.0036347581228842 2520 1643.27272727273 1547 8.03501800357486e-05 380 1.01831689085328 1.17630061783005 1 8.48271707707874 2518 473 2374 1033 380 1547 895 409 4231 2441 1775 1267 M12267 GO_ECTODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. 28/39 Gene Ontology BP GO:0007398 0.00194124962494674 0.00639120213122408 725 1708.27272727273 1547 0.000176633152350881 253 1.61373844496017 -1.71005348545101 -1 12.0965677441888 725 2721 1547 2502 4214 336 253 267 3452 2169 605 1268 M16582 GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 1235/1720 Gene Ontology BP GO:0010648 4.83257389784981e-06 6.75700114917743e-05 1275 2005 1548 4.83258440707868e-07 138 1.12030993819537 1.17847181937456 1 15.9625501814235 1273 1273 4637 2258 3473 1372 2048 1548 2698 138 1337 1269 M10054 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. 60/82 Gene Ontology BP GO:0030858 0.00432450204433333 0.0113887260088382 2220 1716.54545454545 1549 0.00039391146459 663 1.47856824445911 1.29650767968128 1 9.81414115783744 2219 1549 663 2083 1512 1145 1155 3546 2097 712 2201 1270 M14232 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. 939/1312 Gene Ontology BP GO:1902533 3.01054968087459e-05 0.000305470471943432 1055 1813.63636363636 1549 3.01059046699447e-06 184 1.16697898014978 1.20398326380466 1 14.0137466516066 1053 1292 4481 742 2619 1092 1549 2479 2639 184 1820 1271 M15883 GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 17/22 Gene Ontology BP GO:0043649 0.00577426225782821 0.0134540021460564 2675 1575 1552 0.000526315789473684 80 1.3253697589605 -1.15140215448319 -1 8.46820247707934 2673 439 1552 80 2278 2335 2126 1420 1065 1051 2306 1272 M16575 GO_POSITIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXONOGENESIS.html Any process that activates or increases the frequency, rate or extent of axonogenesis. 93/107 Gene Ontology BP GO:0050772 0.144292957147179 0.183091117972682 1130 2411.09090909091 1552 0.0140662419966141 1057 1.20359516675777 1.14456693867857 1 3.02348246647123 1126 3674 1481 2888 4301 1057 1459 4292 3178 1514 1552 1273 M15834 GO_CYTOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOLYSIS.html The rupture of cell membranes and the loss of cytoplasm. 22/49 Gene Ontology BP GO:0019835 0.00161685841956687 0.00565657310243959 4355 2384.72727272727 1553 0.000147095266412037 377 1.51055511049529 1.8601503697263 1 11.5962941746773 4352 377 543 1448 1223 3193 4221 1241 3704 1553 4377 1274 M12204 GO_CITRULLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CITRULLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. 9/13 Gene Ontology BP GO:0000052 0.0132852527745134 0.0257032354094848 2315 1901.27272727273 1555 0.00133653516258389 310 1.50382837750699 -1.40380092452553 -1 8.1644010694714 2313 1243 4356 1484 2549 2733 2673 764 310 934 1555 1275 M15598 GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 55/82 Gene Ontology BP GO:0050994 0.102311077725745 0.136483212344579 1400 1702.09090909091 1556 0.00976399079542567 843 1.07118797055162 1.01780075375385 1 3.15696711584171 1396 1555 1507 843 1754 1556 1876 2447 1711 1328 2750 1276 M16959 GO_FRUCTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRUCTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. 22/26 Gene Ontology BP GO:0006000 0.000793688471195317 0.00337880371131913 1805 1672.09090909091 1556 7.2179541172318e-05 222 1.45595629944872 -1.70162619078048 -1 12.2907548389957 1805 3148 2265 2028 363 222 439 4323 803 1556 1441 1277 M14063 GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of smoothened signaling. 64/92 Gene Ontology BP GO:0008589 0.0563263993463483 0.0825990344023191 3195 1710.09090909091 1557 0.00525658415787367 121 1.1769287548697 -1.07015998587003 -1 4.34727563459317 3192 121 1557 992 1497 1663 2837 2590 1543 1857 962 1278 M11401 GO_CLATHRIN_COAT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_ASSEMBLY.html The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. 11/13 Gene Ontology BP GO:0048268 0.0575192378366885 0.0839250591577647 935 1941.09090909091 1558 0.00537095830934565 814 0.690825150619278 -0.72493236120653 -1 2.53099200780191 933 2381 3419 1588 1558 2002 1290 1345 1547 4475 814 1279 M14229 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. 23/32 Gene Ontology BP GO:1902547 0.0145008727410865 0.0275575783874681 1560 1538.54545454545 1559 0.00132703125716161 297 1.31709381433028 1.40476981732055 1 7.0130479286348 1559 1684 1225 1774 1143 1987 2746 2308 1289 912 297 1280 M11510 GO_NEGATIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. 11/18 Gene Ontology BP GO:0046851 0.000246397253595279 0.0014736329318494 4100 2102.63636363636 1561 2.24022594643543e-05 207 1.77851028069909 -2.23054334321671 -1 17.2073228063726 4099 1842 1109 1561 207 4110 3580 672 838 794 4317 1281 M15685 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 98/149 Gene Ontology BP GO:0021954 0.00112706059908831 0.0043046024109273 1240 2204.54545454545 1563 0.000102512582454385 518 1.25317436418565 1.24907628025576 1 10.126839176697 1236 2579 518 3429 4484 1497 601 3324 3906 1113 1563 1282 M15758 GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY.html Any process that initiates the activity of an inactive protein kinase. 312/415 Gene Ontology BP GO:0032147 0.00205744060428479 0.00663888427998413 1665 1650.18181818182 1564 0.000187215204208178 575 1.22661029020697 1.24395013168539 1 9.12285198049299 1662 1940 575 657 3995 1146 1441 1982 1564 804 2386 1283 M14182 GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in an epithelial cell. 47/55 Gene Ontology BP GO:1904019 0.0186816501714847 0.0336399838420737 225 1761.63636363636 1565 0.00171292730212429 221 1.12439377954704 1.18594939805807 1 5.65246187231939 221 2171 1565 2470 1099 1271 1544 2302 3947 2071 717 1284 M14904 GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION.html A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. 608/995 Gene Ontology BP GO:0003006 0.000877378800266016 0.00361278190941396 1760 1849.90909090909 1565 8.77725399979319e-05 338 1.19207632662827 1.17417018026655 1 9.94271035864644 1760 594 4523 1206 2684 1483 1565 2126 1526 338 2544 1285 M13368 GO_GRANULOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_MIGRATION.html The movement of a granulocyte within or between different tissues and organs of the body. 61/100 Gene Ontology BP GO:0097530 1.12046175336738e-05 0.000139772346874488 815 1606.72727272727 1566 1.01860678175337e-06 259 1.48690269405251 1.52968191895047 1 19.5846359292431 815 2122 261 999 3939 1370 1566 2128 1831 259 2384 1286 M13807 GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. 83/130 Gene Ontology BP GO:0050728 2.24860544747429e-05 0.000244457036147147 2165 1540.45454545455 1566 2.04420766422792e-06 79 1.44480522121009 1.50535733763306 1 17.8305802192073 2164 79 282 108 4512 2185 1969 2633 1200 247 1566 1287 M13024 GO_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 89/116 Gene Ontology BP GO:0048145 0.0570991724467065 0.0834954272138671 4370 2470.45454545455 1568 0.00533066574680446 945 1.12662324960759 -0.886142474646442 -1 4.14294765802019 4366 1477 1520 1568 1502 4233 4022 2114 1223 945 4205 1288 M11145 GO_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_MORPHOGENESIS.html The process in which the anatomical structures of the lung are generated and organized. 50/70 Gene Ontology BP GO:0060425 0.084378620757351 0.115986328621552 3430 2258.18181818182 1569 0.00798182391577328 953 1.24907701808744 -1.09012825480295 -1 3.98481477465973 3430 1569 1472 1079 2269 4316 2952 1517 953 1311 3972 1289 M12594 GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 184/241 Gene Ontology BP GO:0071453 0.0108219672472705 0.0219410081052503 865 1901.36363636364 1570 0.000988688258578459 312 1.12937932213603 1.14571346603119 1 6.39422412361093 864 4294 1570 3409 2889 312 953 661 3107 1967 889 1290 M11653 GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. 41/52 Gene Ontology BP GO:0008154 0.00577426225782821 0.0134540021460564 3395 1739.90909090909 1571 0.000526315789473684 168 1.1863638170991 -1.45486125426868 -1 7.57893166266967 3393 927 2307 168 1571 2952 3605 1595 876 1319 426 1291 M14792 GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neuron migration. 23/24 Gene Ontology BP GO:2001224 8.08162759156132e-05 0.000633060828005637 195 1221.45454545455 1572 7.34720407523617e-06 23 1.97990000564142 1.97990000564142 1 21.640909424703 192 2270 1578 2362 1572 209 23 27 2677 2156 370 1292 M10794 GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. 33/44 Gene Ontology BP GO:0051145 0.0401460503690532 0.0623913067358732 1160 2216.54545454545 1574 0.00371799307444685 836 1.53129303679086 1.51776811255574 1 6.29735707810273 1156 4430 1574 4063 1370 983 939 2363 3728 2940 836 1293 M10711 GO_NITROGEN_CYCLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_CYCLE_METABOLIC_PROCESS.html A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. 11/30 Gene Ontology BP GO:0071941 0.00599710421740899 0.0138209638056484 2395 1732.45454545455 1575 0.000546683156792634 66 1.54681040597388 -1.76827703826608 -1 9.82303222611164 2394 520 1575 302 4233 3621 3363 491 66 793 1699 1294 M11600 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 49/67 Gene Ontology BP GO:0043268 0.00218883839326036 0.00692469022725366 4215 2073.27272727273 1576 0.000199183560442776 583 1.26823925626317 -1.30773891215572 -1 9.35345482087471 4214 1576 583 1989 1081 2854 4428 1403 1339 987 2352 1295 M13877 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS.html The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. 73/110 Gene Ontology BP GO:0017156 0.00577426225782821 0.0134540021460564 3155 1791.63636363636 1576 0.000526315789473684 111 1.16157342827012 -1.30330316798409 -1 7.42033866320304 3154 829 2111 111 1576 2687 4103 2486 551 1289 811 1296 M14737 GO_RESPONSE_TO_PARATHYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PARATHYROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. 22/27 Gene Ontology BP GO:0071107 0.0192059777129609 0.0344242736126376 1580 2083.81818181818 1576 0.001761429454545 562 1.51184123384271 1.46151580783762 1 7.55214510980313 1576 4496 1651 4350 4217 1477 740 845 1813 1195 562 1297 M11008 GO_LYMPHOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. 53/71 Gene Ontology BP GO:0002260 0.0294617691316252 0.0485448361749629 1595 1760 1577 0.00271489745375184 475 0.889938328779073 0.914425530009643 1 3.98694718965997 1595 864 2972 902 4029 1857 475 1100 651 3338 1577 1298 M12168 GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. 18/24 Gene Ontology BP GO:0051446 6.42534219708472e-05 0.00053812731406324 3140 1786.36363636364 1577 5.84139078540971e-06 110 1.40456756234785 -1.60774277998327 -1 15.6880934586967 3140 1114 1577 1651 110 2984 4067 1186 364 2130 1327 1299 M14377 GO_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_FORMATION.html Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. 156/190 Gene Ontology BP GO:0035148 0.070097249144889 0.0991978407150756 1340 1757.54545454545 1577 0.00658506528171919 606 1.16165600998323 1.13083989122687 1 3.97486996714098 1338 1420 1991 606 1577 1642 2252 3404 996 2680 1427 1300 M16732 GO_THYROID_HORMONE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_GENERATION.html The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. 6/13 Gene Ontology BP GO:0006590 3.15921248109863e-05 0.000318177828453505 1910 1983.18181818182 1577 3.15925739480303e-06 79 2.22609780470122 1.88966539068317 1 26.6072061978227 1909 2920 4644 787 79 642 905 3954 1388 1577 3010 1301 M16055 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 50/54 Gene Ontology BP GO:0060999 0.00573833095070289 0.0134540021460564 1400 1454.27272727273 1579 0.000523032119064841 365 1.1025945483379 1.18252471099343 1 7.04302963678322 1398 881 1785 365 1192 1899 2527 479 1887 1579 2005 1302 M16401 GO_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. 15/19 Gene Ontology BP GO:0070231 4.32196495404109e-05 0.000399803239187937 440 1721.45454545455 1579 3.92913623877631e-06 92 0.672956543732533 -0.657885773392616 -1 7.80781951512694 2124 438 3061 440 92 2523 3120 1568 541 3450 1579 1303 M12806 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. 26/43 Gene Ontology BP GO:0051769 0.00207036111981839 0.00666209563659403 200 1390.63636363636 1580 0.000188392004736383 198 1.16683301012875 1.34297160530956 1 8.67169494957935 198 2241 1580 1597 2447 423 236 273 3934 1978 390 1304 M16559 GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. 42/64 Gene Ontology BP GO:0034308 0.000216542235512216 0.00133985508223184 1580 1692.72727272727 1580 1.96875956664939e-05 194 1.47224716127372 -1.41195199836952 -1 14.4503938958584 1580 2661 402 1443 194 1604 2790 4439 1371 314 1822 1305 M15467 GO_NEGATIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSSIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation. 71/94 Gene Ontology BP GO:0030279 0.000451687681756897 0.00227211111698902 2295 1646 1581 4.10709495987531e-05 290 1.4366040039731 1.40782385306773 1 12.9736920990921 2292 2117 497 1687 1413 2883 2742 1581 1313 290 1291 1306 M10568 GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 55/97 Gene Ontology BP GO:0032890 0.022940622980796 0.0396371031302057 1300 1970 1582 0.00210758083016835 933 1.32453781583614 1.47181886142701 1 6.33786796225088 1297 2639 933 3496 2593 1211 1726 1498 3659 1582 1036 1307 M11100 GO_HYALURONAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 18/19 Gene Ontology BP GO:0030214 0.0173685158393295 0.0317796713332286 2795 1915.54545454545 1582 0.00159156103718352 342 1.29081568903818 -0.783411670292972 -1 6.59969783816166 2794 1083 1582 1231 1958 1009 342 3804 691 2129 4448 1308 M13722 GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 116/172 Gene Ontology BP GO:0010906 0.00367898777373957 0.0101592463568013 950 1864.63636363636 1582 0.000335014042395511 364 1.08956493494066 1.13478771462931 1 7.41410743469075 949 1451 2126 3204 3780 1473 1582 371 2496 2715 364 1309 M11050 GO_LYMPHOCYTE_COSTIMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_COSTIMULATION.html The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. 55/114 Gene Ontology BP GO:0031294 0.00157456438266229 0.0055377536451456 1860 1355.18181818182 1583 0.000143244767847142 154 1.26634735217668 1.30780812047886 1 9.75974347269345 2130 154 1240 194 470 1859 1859 3053 605 1583 1760 1310 M13908 GO_NEUROGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROGENESIS.html Generation of cells within the nervous system. 1416/1999 Gene Ontology BP GO:0022008 1.31683748847908e-08 4.05777803569084e-07 1265 1814.63636363636 1584 1.31683749628236e-09 56 1.1958955367015 1.24044360799874 1 26.1231539576056 1157 1265 4459 1167 2882 1261 1584 2266 2030 56 1834 1311 M11435 GO_OXALOACETATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALOACETATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. 11/12 Gene Ontology BP GO:0006107 0.000840854479792308 0.00351211480652927 1340 1918.45454545455 1586 7.64705483619112e-05 372 0.72381261753772 -0.836526677270337 -1 6.06326256119997 1337 2889 3299 2126 372 996 1579 1586 2170 3672 1077 1312 M16741 GO_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 330/422 Gene Ontology BP GO:0009100 4.6620801466622e-07 9.07642632737205e-06 3160 2056.90909090909 1586 4.23825557692422e-08 177 1.29404049123346 -1.21842341126454 -1 22.2968143357718 3156 636 182 256 964 3337 4360 3361 1586 177 4611 1313 M13588 GO_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that modulates the frequency, rate or extent of muscle hypertrophy. 45/55 Gene Ontology BP GO:0014743 2.16425925058634e-05 0.000238632660971049 2205 1532.45454545455 1587 1.96752776533724e-06 55 1.24566248025106 1.33668681995351 1 15.4160585553865 2205 1587 1959 428 55 2490 2821 1515 762 621 2414 1314 M14491 GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE.html The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. 4/15 Gene Ontology BP GO:0007342 0.00400950704835689 0.0108214827703043 3230 1855.90909090909 1587 0.000401675973833778 144 1.7646255665197 -1.60951984163891 -1 11.8488035319301 3228 561 4497 511 700 1344 1823 1587 144 1990 4030 1315 M14662 GO_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_ANION_GENERATION.html The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. 10/16 Gene Ontology BP GO:0042554 0.0416165994518267 0.0642901850097443 3930 1996.54545454545 1587 0.00385684969699897 746 1.85472936809443 1.55688150501216 1 7.54715660578016 2548 3927 1198 3928 1387 1949 1475 2130 746 1087 1587 1316 M16968 GO_HEAD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_MORPHOGENESIS.html The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. 55/69 Gene Ontology BP GO:0060323 0.0180730565232079 0.0328104004827544 300 1696.54545454545 1587 0.00165665977082576 298 1.22173329368876 1.37756240712689 1 6.18801919420943 298 2635 1059 2236 1368 1587 1756 2207 3846 1329 341 1317 M13904 GO_METANEPHRIC_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 26/42 Gene Ontology BP GO:0072210 0.0859418494156082 0.117787165045898 565 1742.81818181818 1589 0.00813591261653708 562 1.33530680991257 1.3441734196294 1 4.23009431739119 562 2747 1336 2822 3210 782 914 1571 1659 1979 1589 1318 M13761 GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell. 36/55 Gene Ontology BP GO:0042491 0.0115794121375892 0.0231339650820965 1890 1471.45454545455 1590 0.00105825561581638 258 1.42868258723758 1.29088422375763 1 7.97930595142212 1887 2200 2072 1685 1421 521 258 3129 917 1590 506 1319 M14343 GO_CELLULAR_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 74/117 Gene Ontology BP GO:0071398 1.55696589334464e-05 0.000183406640550193 1590 1711.27272727273 1590 1.41543355662245e-06 105 1.35000034688875 1.35687406389785 1 17.2358445621039 1590 105 270 1553 4520 1678 1166 1877 3296 231 2538 1320 M16367 GO_PHOSPHOLIPID_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_EFFLUX.html The directed movement of a phospholipid out of a cell or organelle. 9/18 Gene Ontology BP GO:0033700 0.00129920084119304 0.00481687770045515 2495 2102.54545454545 1590 0.000129996103204488 455 1.30036381840325 -1.59478683660423 -1 10.2914727561339 2493 1245 4618 1060 455 1590 2808 1485 4261 2190 923 1321 M10730 GO_NADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. 32/41 Gene Ontology BP GO:0006739 0.000526071837341722 0.00250543731745244 1770 1485.18181818182 1592 4.78361523311672e-05 269 1.18550675461837 -1.3219626223794 -1 10.5321440320619 1770 269 2051 1186 307 1375 2561 1683 1592 991 2552 1322 M13000 GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. 185/204 Gene Ontology BP GO:0007265 0.0572088071909066 0.0836031971919876 1665 1691.90909090909 1592 0.00534118030886523 401 1.10454509216325 1.04454397480516 1 4.05943487108575 1661 1404 2384 401 1504 1592 1294 2075 1411 1815 3070 1323 M16060 GO_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTOSIS.html A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. 485/858 Gene Ontology BP GO:0006897 2.21529500491091e-05 0.00024325498364668 1970 1588.36363636364 1593 2.01392482926257e-06 26 1.18797280753315 1.19223421837233 1 14.6677685731366 1968 603 280 26 1593 2990 2521 2529 1559 243 3160 1324 M11535 GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. 18/36 Gene Ontology BP GO:1902932 0.0182737253487041 0.0330461111727634 3530 2097.54545454545 1596 0.00167520910467419 275 1.42343828874522 -1.81848396054239 -1 7.19627587707172 3526 429 1242 420 1095 4509 2492 2963 275 1596 4526 1325 M12350 GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. 41/72 Gene Ontology BP GO:0001754 0.0095888293629701 0.0200270475881494 2300 1892.36363636364 1596 0.000875534514048271 782 1.3407078050481 -1.37297595147941 -1 7.7744016117301 2298 1596 782 1769 1495 1075 1348 3583 1888 1320 3662 1326 M12750 GO_ATP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. 36/46 Gene Ontology BP GO:0006754 0.00050609846227236 0.00244281757775238 215 1657.54545454545 1596 4.60195386435872e-05 170 0.632752529390168 -0.588798882027499 -1 5.64023692942633 211 1621 3905 2617 297 453 170 1524 1596 4132 1707 1327 M14605 GO_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/46 Gene Ontology BP GO:0051955 0.0172949779429885 0.0316949713937476 1725 1685.81818181818 1597 0.00158476866754555 439 1.71280625705916 1.88320491000441 1 8.76752939713168 1723 2260 890 1289 1597 1476 2583 3246 1361 1680 439 1328 M13018 GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. 18/28 Gene Ontology BP GO:0045672 0.001811116223046 0.00609587405331511 240 2005.63636363636 1598 0.000164782628847863 236 1.44722785128271 1.38614256171438 1 10.9489700642285 236 3882 1766 4243 3142 1085 413 250 4495 1598 952 1329 M16139 GO_RENAL_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_FILTRATION.html A renal system process in which fluid circulating through the body is filtered through a barrier system. 9/13 Gene Ontology BP GO:0097205 0.000167812944371284 0.00109821888911334 1555 1810 1599 1.67825618251239e-05 54 1.57084318923369 1.79125285259074 1 15.8827028028641 1554 3598 4596 1800 2781 1599 567 54 85 2889 387 1330 M15001 GO_CONVERGENT_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONVERGENT_EXTENSION.html The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. 21/25 Gene Ontology BP GO:0060026 0.0978342782683997 0.131453334329444 3020 1774.18181818182 1600 0.00931606576211447 180 1.41371320403229 1.59368801116974 1 4.24867632395656 3016 363 1422 659 3358 3273 2686 1600 180 1093 1866 1331 M16383 GO_RECEPTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 19/24 Gene Ontology BP GO:0032801 1.23372664107645e-05 0.000151066580550756 3525 1637.27272727273 1600 1.12157596334791e-06 34 1.05478324764038 -1.16832377401218 -1 13.7682051965993 3525 1089 3251 231 34 2409 2615 390 130 2736 1600 1332 M14692 GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT.html The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. 19/24 Gene Ontology BP GO:0060749 1.56969794437478e-05 0.000183512676763213 2660 1818.63636363636 1601 1.42700831296984e-06 39 1.64751622865666 -1.69587149185791 -1 21.0352517746142 2656 389 395 134 39 4568 4134 3319 2461 309 1601 1333 M12080 GO_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. 108/163 Gene Ontology BP GO:0042752 0.0369988931895502 0.0584768512265548 655 1777 1602 0.00342147136762683 539 0.936209631547142 1.02955482355915 1 3.93603840322794 654 781 3384 2402 2472 668 539 1602 2342 3721 982 1334 M15053 GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT.html The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. 19/24 Gene Ontology BP GO:0061377 1.56969794437478e-05 0.000183512676763213 2660 1798.72727272727 1602 1.42700831296984e-06 40 1.64751622865666 -1.69587149185791 -1 21.0352517746142 2657 390 396 135 40 4569 4135 3090 2462 310 1602 1335 M15175 GO_LIPOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving liposaccharide. 93/115 Gene Ontology BP GO:1903509 0.00577426225782821 0.0134540021460564 1605 1478.36363636364 1602 0.000526315789473684 51 1.09152162530845 -0.826066354716162 -1 6.97219218085548 1602 51 2242 59 838 564 2385 3608 366 2264 2283 1336 M13011 GO_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a cell population. 767/1073 Gene Ontology BP GO:0008283 0.00149705734493501 0.0053174105541852 705 1871.09090909091 1603 0.000149806683351155 372 1.25238995956007 1.27618260608943 1 9.7275601096544 705 1896 4400 2281 4382 631 1009 826 2477 372 1603 1337 M14167 GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 12/18 Gene Ontology BP GO:0060391 1.04986713286593e-05 0.000133107132676436 3880 1975.09090909091 1603 9.54429220904404e-07 29 1.34430258368222 1.36870080786105 1 17.8028947561073 3879 1205 1939 655 29 4453 4267 1603 127 1373 2196 1338 M13875 GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. 76/104 Gene Ontology BP GO:0045639 0.0215081399072424 0.0375524859243524 900 1948.36363636364 1604 0.00197466695126899 894 1.25049327333073 1.21490296955694 1 6.08328523946317 900 3015 1164 3341 2299 2355 1503 894 3376 981 1604 1339 M13362 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 29/39 Gene Ontology BP GO:0098901 0.0107710818523958 0.0218568878583504 3135 1705.45454545455 1605 0.000984016436963784 620 1.15727882798455 -1.29753131372285 -1 6.55904732591354 3132 993 1605 620 1785 1002 3010 660 2983 1819 1151 1340 M14713 GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. 27/27 Gene Ontology BP GO:0009081 0.000151812988809236 0.00103321580537707 1440 1641.45454545455 1605 1.38021332558134e-05 137 0.728988832047871 -0.723162397770226 -1 7.4310912498789 1436 2231 3573 1809 162 375 1605 948 1606 4174 137 1341 M12303 GO_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. 305/465 Gene Ontology BP GO:0019216 1.40895372902171e-05 0.000170282122107481 1610 1442.54545454545 1606 1.28087522955862e-06 266 1.14252497899977 1.19611014125437 1 14.7112682660711 1606 646 266 319 2665 803 1766 3298 1748 334 2417 1342 M16543 GO_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_PATTERNING.html The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. 35/52 Gene Ontology BP GO:0021532 0.00294477963906154 0.00861764758525369 705 1428.09090909091 1606 0.000268066248691325 51 1.03961131252352 -0.987362290304762 -1 7.32774278442371 704 1627 2563 1606 2894 51 1066 464 1824 2675 235 1343 M12017 GO_ORGANOPHOSPHATE_ESTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSPORT.html The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. 80/106 Gene Ontology BP GO:0015748 0.0173586818813384 0.0317796713332286 1635 1355.90909090909 1607 0.00159065269129228 84 0.991821849106698 -0.965693957662269 -1 5.06852874224257 1633 84 2447 940 1910 306 1791 1003 2859 1607 335 1344 M12221 GO_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_EXTRAVASATION.html The migration of a leukocyte from the blood vessels into the surrounding tissue. 29/37 Gene Ontology BP GO:0045123 0.0379453801349602 0.0596485992459357 210 1865.54545454545 1607 0.00351055558772169 207 1.34131410634256 1.40100283435327 1 5.60429047055954 207 2720 1204 1607 3805 766 551 2361 4376 1818 1106 1345 M15567 GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of leukocyte degranulation. 38/56 Gene Ontology BP GO:0043300 0.00805155080177447 0.0174409086496302 420 1522.18181818182 1607 0.000734651791279927 292 0.88281133895365 0.970749774256181 1 5.29678375642799 416 1607 3024 1896 1619 670 292 577 2107 3215 1321 1346 M16239 GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. 636/1026 Gene Ontology BP GO:0045596 1.20523482896185e-05 0.00014889223152653 1230 1823.45454545455 1607 1.20524136567122e-06 158 1.26089530182291 1.30093733570425 1 16.4878359542526 1229 2448 4607 2320 1703 1397 1607 1033 2418 158 1138 1347 M16711 GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION.html Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. 21/23 Gene Ontology BP GO:0048070 0.0090727959177822 0.0191628322312486 760 1702.45454545455 1607 0.00082822087026927 221 1.20698247997919 1.2872260901694 1 7.07695554571455 757 1729 1607 3498 3629 693 221 1331 2839 1949 474 1348 M11681 GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 412/516 Gene Ontology BP GO:0090407 0.0274341204199266 0.0460501307048768 1460 1775.54545454545 1608 0.00252566542514336 380 0.939201778003499 -0.909179471760277 -1 4.28181184113461 1459 617 3680 930 2397 380 1657 2442 1178 3183 1608 1349 M12361 GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. 34/51 Gene Ontology BP GO:0050850 0.00577426225782821 0.0134540021460564 4350 2334.54545454545 1610 0.000526315789473684 189 1.08761015755744 -0.914919660366369 -1 6.94716912021579 4347 254 1610 189 1235 3777 3789 4168 780 1137 4394 1350 M11029 GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 84/108 Gene Ontology BP GO:0071322 0.00114552536694514 0.00434757710635867 135 1607.90909090909 1611 0.000104192933595838 46 1.11498396533095 1.14442885048846 1 8.99250746691823 131 3007 2518 2898 4581 52 46 428 1611 2085 330 1351 M16019 GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. 9/17 Gene Ontology BP GO:0007171 0.000219760742393233 0.0013561627776601 1435 1747.09090909091 1611 2.19782478071258e-05 63 1.61844585644994 1.44963981599145 1 15.8573491895649 1432 1856 4587 1797 1326 2225 1611 63 693 2189 1439 1352 M14486 GO_RESPONSE_TO_MUSCLE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. 36/61 Gene Ontology BP GO:0014850 0.0149326890927357 0.0281759133611108 1615 1559.72727272727 1612 0.00136681997666485 251 1.13621434298203 1.27562035044839 1 6.01102961038735 1612 251 1400 2383 1025 2483 1803 1649 1174 1592 1785 1353 M12597 GO_DNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS.html The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 26/30 Gene Ontology BP GO:0006308 0.00228802947006748 0.00716433453850873 3795 2123 1613 0.000208219320168755 76 0.844223731145423 -0.989528585863138 -1 6.18006440147131 1329 4139 3791 3793 1613 922 1375 689 1698 3928 76 1354 M13815 GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. 109/135 Gene Ontology BP GO:0046434 0.0623761148111547 0.0897229446119802 3700 1956.18181818182 1613 0.00583801812542646 30 1.25810289827292 -1.21245733657146 -1 4.49330509586639 3700 30 1613 276 3826 1479 2655 3249 649 826 3215 1355 M10467 GO_MYELOID_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 106/127 Gene Ontology BP GO:0002262 0.0271661462565052 0.0456497213909421 1615 1728.27272727273 1614 0.00250068334752099 772 1.06653489686406 1.08752114745911 1 4.87759784452237 1614 778 2322 772 2533 3219 1939 980 1140 1239 2475 1356 M14440 GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion. 12/14 Gene Ontology BP GO:0006851 0.0441826123857743 0.0672695983754418 1215 2188.18181818182 1614 0.00409961004412361 1034 0.688062765386876 -0.639164857784657 -1 2.74683530243651 1642 1212 3314 1567 1959 1034 1478 1212 4461 4577 1614 1357 M16316 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. 16/23 Gene Ontology BP GO:0002888 0.00102663983963554 0.00405170074115705 95 1453.36363636364 1614 9.33744762670019e-05 48 1.41322558456164 1.41322558456164 1 11.5486208789223 95 2323 1954 1614 3914 167 48 183 2427 3008 254 1358 M10809 GO_NEURON_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. 44/65 Gene Ontology BP GO:0042551 0.0628228099276871 0.0901579486126953 2205 1591.54545454545 1616 0.0058810847737143 646 1.10798158981815 1.08442059250774 1 3.94791866820192 812 912 1616 2328 2340 646 1176 2202 1722 2203 1550 1359 M12931 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. 27/35 Gene Ontology BP GO:0071634 0.00481036721735427 0.0122644595410134 495 2070.27272727273 1617 0.000438265231132588 423 1.17314369702543 1.24010507754343 1 7.65560900867189 493 4125 1911 4345 3205 1198 663 423 3619 1617 1174 1360 M11883 GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. 16/22 Gene Ontology BP GO:0035067 0.0590711809350953 0.0857591902936033 2165 2166.45454545455 1618 0.00551996200175301 480 0.706174317232029 0.706174317232029 1 2.56479542909133 2165 480 3677 1432 2294 718 1618 1361 4496 4491 1099 1361 M15044 GO_RESPONSE_TO_THYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_THYROID_HORMONE.html A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 29/42 Gene Ontology BP GO:0097066 0.00496740080614671 0.0125452115164894 2860 1455.27272727273 1618 0.000452604757309191 171 1.33843966328024 1.38748448241964 1 8.69080615858621 2859 300 1618 171 2351 2315 1404 435 224 1820 2511 1362 M16048 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 27/29 Gene Ontology BP GO:0010662 0.00695141284456288 0.0155280479912391 3245 1838.18181818182 1618 0.000633952282820241 537 1.33664671808457 1.37319890326776 1 8.25579715755453 3244 1008 1076 1023 2548 3861 2458 537 1994 1618 853 1363 M11502 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 38/54 Gene Ontology BP GO:0090313 0.000351253909865802 0.00189823977073818 2545 1502.90909090909 1619 3.19372730826196e-05 145 0.926421589002879 -0.754431781557519 -1 8.60985179839584 2543 231 2800 617 250 643 1619 3437 145 2511 1736 1364 M13200 GO_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of B cell differentiation. 27/36 Gene Ontology BP GO:0045577 0.00335343805293997 0.00953179429464245 4255 1835.27272727273 1619 0.000305323690908653 141 1.31956682362571 -1.27497976834147 -1 9.10635046606181 4252 311 1619 141 615 2821 4587 1746 886 925 2285 1365 M12835 GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. 25/27 Gene Ontology BP GO:2000369 0.00744940056658635 0.0163858585850115 1620 1769.54545454545 1620 0.000679522285854517 243 1.08441024722863 0.898896743358469 1 6.60926692862894 1620 2261 3325 1407 2310 1791 1063 556 243 3889 1000 1366 M10528 GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/20 Gene Ontology BP GO:0010766 0.00237751881668897 0.00733593836475714 630 1539.18181818182 1622 0.000216372006588541 130 1.15626608636779 1.24099266352988 1 8.42764544631104 626 2342 1927 3312 1667 1077 130 295 1622 2902 1031 1367 M11525 GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. 36/41 Gene Ontology BP GO:1900026 0.00364133754657907 0.010091211199662 2560 1748.36363636364 1622 0.000331579865617271 365 1.22352052129601 -1.19460475410114 -1 8.33914642148821 2560 1622 2066 589 1636 2790 3507 365 1169 1589 1339 1368 M13439 GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. 93/123 Gene Ontology BP GO:0006767 0.00856167638813654 0.0182824599513535 3080 1654.18181818182 1622 0.000781379844456766 47 1.18005681180946 -1.2246563098584 -1 7.00124917428278 3076 47 769 252 1803 1622 2835 3680 407 783 2922 1369 M15478 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY.html The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. 139/229 Gene Ontology BP GO:0000184 0.00835169561023198 0.0179493947687803 80 2403.45454545455 1622 0.00076214273282173 79 0.667915200170845 0.638295270694205 1 3.97633137070647 79 4330 4200 4496 863 554 249 1201 4425 4419 1622 1370 M10578 GO_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LOCALIZATION.html Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. 267/339 Gene Ontology BP GO:0051648 0.00143580151562271 0.00515492627483987 2865 1994.09090909091 1623 0.000130612675451689 368 1.06769533825618 -1.0937278377475 -1 8.34062708777322 2861 1378 3232 368 459 1623 3102 3210 1149 3217 1336 1371 M11219 GO_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. 1539/2124 Gene Ontology BP GO:0044281 2.60762911660269e-05 0.000275131480261957 1865 1670.36363636364 1623 2.60765971589128e-06 1 1.10387548210517 -1.02127481924408 -1 13.4268404629489 1863 565 4286 1 1623 843 2264 2935 1363 178 2453 1372 M13423 GO_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. 1529/2245 Gene Ontology BP GO:0045595 2.08251773928644e-11 1.38427929155712e-09 895 1776.81818181818 1623 2.08251773930596e-12 25 1.20607106173951 1.23941359906152 1 36.5184436466862 893 1877 4428 1174 2786 1348 1623 1324 2366 25 1701 1373 M13821 GO_DISTAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISTAL_TUBULE_DEVELOPMENT.html The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. 12/19 Gene Ontology BP GO:0072017 0.00577426225782821 0.0134540021460564 2970 1587.36363636364 1623 0.000526315789473684 153 1.41173215373522 -1.52644212598336 -1 9.02069365916327 2967 504 1634 153 3955 1099 2210 1789 157 1370 1623 1374 M12572 GO_MUSCLE_STRUCTURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_STRUCTURE_DEVELOPMENT.html The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. 452/653 Gene Ontology BP GO:0061061 1.63046176839446e-09 6.59699009420821e-08 1070 1658.63636363636 1624 1.48223797236621e-10 85 1.2051905888683 1.23316178939578 1 29.5771021829023 1066 1343 85 2266 4384 1782 1908 1624 2981 226 580 1375 M14542 GO_ICOSANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. 75/162 Gene Ontology BP GO:0006690 6.60292533129032e-07 1.22404030145394e-05 195 1978.90909090909 1626 6.00266119367886e-08 191 1.44440642510724 -1.38840985261448 -1 24.2475191443941 4274 825 191 697 1565 4135 2307 1686 1626 193 4269 1376 M10957 GO_SPHINGOMYELIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOMYELIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. 13/14 Gene Ontology BP GO:0006684 0.000158801788436138 0.00105267919871041 2260 1458.18181818182 1627 1.44375683932327e-05 31 1.55297544902945 -1.4789128671053 -1 15.7995795443664 2257 502 2337 349 176 3568 2554 1627 31 2093 546 1377 M16181 GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acid derivative. 75/162 Gene Ontology BP GO:1901568 6.60292533129032e-07 1.22404030145394e-05 195 1989.27272727273 1627 6.00266119367886e-08 192 1.44440642510724 -1.38840985261448 -1 24.2475191443941 4275 826 192 698 1566 4136 2308 1790 1627 194 4270 1378 M13560 GO_BICARBONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSPORT.html The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/52 Gene Ontology BP GO:0015701 0.00331246530118259 0.00943839623172234 1335 1745.36363636364 1628 0.000301587573304599 343 1.60626478153842 1.45659850575816 1 11.1106591981096 1331 3467 1022 2504 1889 2273 1612 343 2133 997 1628 1379 M12045 GO_LIPID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. 105/179 Gene Ontology BP GO:0055088 0.000663455922765238 0.00298266706147502 4285 1860.27272727273 1629 6.03323714783352e-05 23 1.20619118633913 -1.20767975188939 -1 10.4038252196481 4285 23 470 55 1072 3740 2800 3307 1629 601 2481 1380 M12574 GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. 38/49 Gene Ontology BP GO:0036296 0.00209869385248521 0.00671610900661189 100 1621.45454545455 1630 0.000190972598459545 99 1.23991072316091 1.1783777127764 1 9.20059698322781 99 2187 577 2951 1630 940 1016 2080 3596 1755 1005 1381 M12954 GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. 14/31 Gene Ontology BP GO:0045652 0.0556088182570511 0.0817091321109676 2060 1807.45454545455 1630 0.00518784289545244 713 1.3415466825604 -1.45689580889536 -1 4.97840125816319 2058 1798 1546 3010 3198 759 713 2482 1531 1630 1157 1382 M12601 GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 567/886 Gene Ontology BP GO:0032870 0.000240171373309305 0.00144568874515938 1380 1754.81818181818 1631 2.4019733428813e-05 266 1.14549595176252 1.15282324663295 1 11.1115930092563 1377 598 4376 339 3438 949 1631 2149 2249 266 1931 1383 M15782 GO_RESPONSE_TO_HYPEROXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYPEROXIA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. 38/49 Gene Ontology BP GO:0055093 0.00209869385248521 0.00671610900661189 100 1622.81818181818 1631 0.000190972598459545 100 1.23991072316091 1.1783777127764 1 9.20059698322781 100 2188 578 2952 1631 941 1017 2085 3597 1756 1006 1384 M10442 GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS.html The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 32/50 Gene Ontology BP GO:0050951 0.000750607643929225 0.00323686502984493 1635 1580.45454545455 1632 6.82603511465034e-05 268 1.55983947026872 1.40752729998058 1 13.2678654095429 1632 268 619 388 3357 2875 1968 1896 844 322 3216 1385 M11140 GO_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING.html Any process that mediates the transfer of information from one cell to another. 571/1050 Gene Ontology BP GO:0007267 2.51873362379079e-10 1.27387690777158e-08 940 1615 1633 2.51873362407626e-11 32 1.36125708025043 1.34027816927969 1 36.7325977056291 939 1322 4279 1701 1827 231 1633 3380 2287 32 134 1386 M16835 GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that modulates the frequency, rate or extent of execution phase of apoptosis. 30/35 Gene Ontology BP GO:1900117 0.00643784484853329 0.014632543353467 2515 1748.72727272727 1633 0.000586978310242047 396 1.19263348276139 -0.935293176420445 -1 7.47033949297531 2514 991 2144 396 802 3356 1382 2859 1633 2309 850 1387 M11130 GO_GLIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DEVELOPMENT.html The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 86/123 Gene Ontology BP GO:0021782 0.0645619058982913 0.0922825831319811 755 1919.54545454545 1634 0.00604893197029447 755 1.11214817284836 1.15799506011637 1 3.92434120300831 755 1486 1585 1897 4469 2396 971 1634 3187 1919 816 1388 M15749 GO_LIPID_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_LOCALIZATION.html Any process in which a lipid is transported to, or maintained in, a specific location. 236/373 Gene Ontology BP GO:0010876 1.02580251402042e-10 5.89266555276172e-09 2585 1761.18181818182 1634 9.32547740062042e-12 56 1.26462085488084 1.31262175842138 1 35.5718110507421 2584 664 56 247 4461 2815 1634 2642 1240 70 2960 1389 M12400 GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY.html The disaggregation of a macromolecular complex into its constituent components. 212/249 Gene Ontology BP GO:0032984 0.0645181746477054 0.0922825831319811 450 1861.18181818182 1635 0.00604470781441306 448 0.851610960810703 -0.857831575209727 -1 3.00250814081862 448 1968 4102 1116 1726 657 933 2152 1414 4322 1635 1390 M16829 GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). 21/71 Gene Ontology BP GO:0030520 0.0250141783366327 0.0426340556045245 2840 2051.09090909091 1635 0.00230029117274519 412 0.920245165123703 -0.970475058343118 -1 4.3004925390969 2836 412 3048 1572 1635 3802 2816 1405 1235 3385 416 1391 M11645 GO_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 33/62 Gene Ontology BP GO:0043330 0.00462270658883397 0.0119019316413848 1075 1772.72727272727 1636 0.00042113169366284 265 1.42163147496573 1.53893613615537 1 9.34276632653749 1075 3097 1965 2853 715 1636 645 4522 265 1055 1672 1392 M11813 GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response. 8/23 Gene Ontology BP GO:0016056 0.0525080043551285 0.07772847486296 1640 1949.54545454545 1637 0.00537915922312715 254 1.96993440911333 1.96993440911333 1 7.46139323751722 1637 2915 4326 2102 1579 638 730 4277 254 2017 970 1393 M11306 GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. 20/24 Gene Ontology BP GO:0060644 0.105250812216901 0.139604341289977 4455 2284.18181818182 1638 0.0100592310716247 369 1.11126977779478 -0.944710933434452 -1 3.23818511618456 4454 369 1292 852 2832 3633 4319 1638 753 983 4001 1394 M15965 GO_RESPONSE_TO_GONADOTROPIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GONADOTROPIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 24/37 Gene Ontology BP GO:0034698 0.0617756102971002 0.0890464419802996 1640 1595.09090909091 1638 0.00578015182951024 165 1.46610596266433 1.0625591132104 1 5.25442531454582 1638 1041 1887 768 2973 1334 761 3076 165 1785 2118 1395 M16560 GO_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_AGGREGATION.html The adhesion of one platelet to one or more other platelets via adhesion molecules. 56/83 Gene Ontology BP GO:0070527 0.00877373956450363 0.0186324729082773 545 1721.18181818182 1639 0.000800811491838887 543 1.11586008473046 1.0756430772852 1 6.58837105582081 543 2634 1673 4140 875 971 923 1108 2444 1983 1639 1396 M15768 GO_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. 64/92 Gene Ontology BP GO:0048709 0.00200131421159207 0.00652108895415819 1640 1706.36363636364 1640 0.000182103373242299 117 1.2978227271397 1.44794757860468 1 9.68760893582158 1640 117 571 1045 3077 2968 2399 1999 3304 563 1087 1397 M16552 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 14/18 Gene Ontology BP GO:0010661 0.0131891618304953 0.0256024906121379 2680 1977.45454545455 1640 0.00120626380914215 995 1.07852094641613 -1.08147654582829 -1 5.85864755352535 2677 1154 1773 1527 995 2522 3691 1610 1390 1640 2773 1398 M14846 GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. 14/22 Gene Ontology BP GO:0032682 4.2522774917352e-06 6.10674295340861e-05 3860 1961 1641 3.86571428253316e-07 18 1.56043112970781 -0.960632830891951 -1 22.4721773701003 3858 1176 1641 167 18 3118 3220 4564 226 1636 1947 1399 M14627 GO_CERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. 65/80 Gene Ontology BP GO:0006672 0.00313700274845435 0.00904927079265847 4640 2129.27272727273 1642 0.000285589525730703 118 1.33158388352713 -1.05813304689331 -1 9.29208938303724 4640 118 1642 470 603 3689 4432 1858 344 1118 4508 1400 M16400 GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html The directed movement of proteins from the endoplasmic reticulum. 24/29 Gene Ontology BP GO:0032527 0.000797210225469261 0.00338759742384335 805 1827.18181818182 1642 7.24999323464659e-05 364 0.839352874607808 -0.796023068835016 -1 7.07781496471971 805 2266 3843 1642 364 1116 1076 1880 1532 3860 1715 1401 M12249 GO_EPITHELIAL_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_CELL_ADHESION.html The attachment of an epithelial cell to another epithelial cell via adhesion molecules. 20/22 Gene Ontology BP GO:0090136 0.00577307972925447 0.0134540021460564 365 1814.45454545455 1643 0.000526207719490047 166 1.25024071366346 1.33122436998938 1 7.98757505639158 365 4171 2274 3413 1643 440 166 782 3033 3323 349 1402 M15679 GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 177/308 Gene Ontology BP GO:0006140 5.30127351003564e-05 0.000473451547834852 1645 1523.45454545455 1643 4.8194556886644e-06 317 1.19706653265081 1.17847817735779 1 13.5964619499466 1643 1405 317 1993 1871 1576 1684 1797 3132 725 615 1403 M15320 GO_RESPONSE_TO_MINERALOCORTICOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MINERALOCORTICOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. 38/50 Gene Ontology BP GO:0051385 0.000571144900660545 0.00267968427588706 350 2066.45454545455 1644 5.1935748205028e-05 21 0.910962844791132 0.951388446160536 1 7.99965833335274 350 3756 2732 4549 1644 179 21 762 4362 2865 1511 1404 M13031 GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. 31/36 Gene Ontology BP GO:0014742 5.72898144684978e-05 0.000495432304635197 2130 1715 1645 5.20830058153714e-06 101 1.25995267688204 1.33827071409544 1 14.2263926489061 2128 1645 2069 435 101 3631 3900 648 839 1246 2223 1405 M10976 GO_ERYTHROCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_HOMEOSTASIS.html Any process of regulating the production and elimination of erythrocytes within an organism. 89/106 Gene Ontology BP GO:0034101 0.0296143904182403 0.0487599995102874 1840 1651 1646 0.00272915550443984 313 1.07966185835605 1.07838259819603 1 4.83209704768717 1839 803 2402 313 1646 3497 2175 1014 629 944 2899 1406 M15139 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY.html Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. 31/36 Gene Ontology BP GO:0010613 5.72898144684978e-05 0.000495432304635197 2130 1707.27272727273 1646 5.20830058153714e-06 102 1.25995267688204 1.33827071409544 1 14.2263926489061 2129 1646 2070 436 102 3632 3901 552 840 1248 2224 1407 M12501 GO_METALLO_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLO_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. 21/22 Gene Ontology BP GO:0031163 0.0195764099441566 0.0349267774042027 725 2437.09090909091 1647 0.00179570995770004 721 0.548513752031635 -0.548513752031635 -1 2.72140987027826 722 3834 3973 4039 1116 885 721 1428 3932 4511 1647 1408 M13758 GO_IRON_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. 21/22 Gene Ontology BP GO:0016226 0.0195764099441566 0.0349267774042027 725 2439.54545454545 1648 0.00179570995770004 722 0.548513752031635 -0.548513752031635 -1 2.72140987027826 723 3835 3974 4040 1117 886 722 1400 3933 4557 1648 1409 M11062 GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. 30/37 Gene Ontology BP GO:0035025 0.00731949295330768 0.0162021781295408 130 1853.63636363636 1649 0.000667632659302006 130 1.17179242266568 1.28284017316653 1 7.16231731552229 130 2717 740 2961 1649 1018 1202 2209 4455 1903 1406 1410 M15457 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 508/655 Gene Ontology BP GO:0007169 0.030331088788694 0.0496239648853 1525 1925.90909090909 1649 0.00307532092301592 870 1.1183587708489 1.17862225092663 1 4.97650416399753 1521 1332 4558 1548 1847 1875 1978 1082 1649 870 2925 1411 M15445 GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. 10/20 Gene Ontology BP GO:0036148 0.0505673176904087 0.0753409315444994 2740 2014.09090909091 1652 0.00470622261907384 537 1.57770695011465 1.01267508676934 1 6.0467411055939 2736 2902 1815 537 4044 1500 1406 1278 1032 1652 3253 1412 M13619 GO_OXYGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORT.html The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/19 Gene Ontology BP GO:0015671 0.000133337619808546 0.000940030219650248 2195 1857.18181818182 1653 1.33345620998617e-05 159 1.76224221619223 -1.98866169360883 -1 18.2261984165987 2195 557 4439 1486 159 1687 2656 3543 1136 918 1653 1413 M13349 GO_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFIBRIL_ASSEMBLY.html Formation of myofibrils, the repeating units of striated muscle. 48/82 Gene Ontology BP GO:0030239 0.00631608289886155 0.014434545053243 1035 2137 1654 0.000575844477827887 504 1.23762904343831 1.18678591856456 1 7.77761795927499 1035 3740 1359 3753 2726 2043 1405 504 3837 1451 1654 1414 M14701 GO_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGING.html An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). 91/113 Gene Ontology BP GO:0007569 0.00753765540327969 0.0165463884340949 1010 1602.45454545455 1655 0.000687600502849797 189 1.03654145756533 1.06577815743192 1 6.30204056271199 1010 1476 2559 1901 1710 568 189 2824 1107 2628 1655 1415 M16735 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL.html The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. 35/73 Gene Ontology BP GO:0003044 0.00111856695354935 0.00428017437077723 1540 1728.90909090909 1655 0.000101739643850453 516 1.47067345673228 1.33338727880162 1 11.8987165423448 1540 2207 516 2770 2087 2358 1655 821 2882 1215 967 1416 M12823 GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 51/68 Gene Ontology BP GO:0051898 0.0539396656186338 0.079575543476063 1065 1872.09090909091 1658 0.00502812856801106 1062 1.20259230569591 1.18094304893058 1 4.50889160073231 1062 2645 2779 1953 1482 1122 1389 3272 1258 1658 1973 1417 M16768 GO_MULTI_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_BEHAVIOR.html Any process in which an organism has a behavioral effect on another organism of the same or different species. 67/106 Gene Ontology BP GO:0051705 0.0315993173774051 0.0512126867840703 3815 1970 1658 0.00291477549844043 610 1.40897480223814 -1.55502112253447 -1 6.20653749982578 3813 2119 1658 610 1291 1878 4580 1543 1452 2030 696 1418 M13789 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. 26/27 Gene Ontology BP GO:0034198 0.00017657550906786 0.0011404746855641 1660 1696.27272727273 1659 1.6053607535686e-05 183 1.04686365194223 0.968453019697255 1 10.5225331421584 1659 1680 3183 2061 183 701 219 4464 668 3258 583 1419 M13598 GO_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INTERNALIZATION.html A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. 51/81 Gene Ontology BP GO:0031623 0.0115308936672407 0.0230766659069552 3175 2064.81818181818 1660 0.00105379799518725 171 1.30475495142988 -1.46423554569765 -1 7.29103976475231 3173 171 1320 335 946 3336 3162 2973 1159 1660 4478 1420 M16856 GO_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 19/37 Gene Ontology BP GO:0010453 0.000369033701739076 0.00196466111463607 2135 1535.63636363636 1660 3.35541471772485e-05 257 1.50355189697108 1.44304470073645 1 13.9033675520205 2135 1725 1048 1266 257 2737 2363 1810 1003 888 1660 1421 M13732 GO_CELLULAR_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 26/40 Gene Ontology BP GO:0071361 0.0369348897008092 0.0584153778986626 620 1711 1663 0.00341545017415325 473 0.981577575567726 0.994881313291546 1 4.12882524035949 617 1018 1663 2381 3046 473 838 1708 3552 2842 683 1422 M13839 GO_SIGNAL_RELEASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_RELEASE.html The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. 163/246 Gene Ontology BP GO:0023061 0.00577426225782821 0.0134540021460564 3625 1963 1663 0.000526315789473684 100 1.21867460584454 1.01188774136738 1 7.7856353548796 3624 726 922 100 1663 3658 3163 2163 1549 738 3287 1423 M14323 GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. 36/54 Gene Ontology BP GO:0031663 0.0118225874111907 0.0235010442492864 520 1706.36363636364 1663 0.00108060027212426 517 1.03265916438303 1.22880061452788 1 5.74038890113055 517 948 1489 1663 954 3064 2096 1182 3032 2004 1821 1424 M11203 GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 11/13 Gene Ontology BP GO:0009313 0.00225945755645597 0.00709396491915629 545 1718.27272727273 1666 0.000205616492772948 47 1.32259594182377 -0.774459275179818 -1 9.70737189498303 2764 1844 2481 541 541 1455 1666 1534 47 2471 3557 1425 M12878 GO_ORGANIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. 835/1183 Gene Ontology BP GO:0006082 0.000152550882934461 0.00103321580537707 3450 2189.63636363636 1666 1.52561356243708e-05 243 1.158681816836 -1.0979304724496 -1 11.8175363392099 3446 583 4392 243 1519 1666 3313 3888 1562 251 3223 1426 M15398 GO_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_GROWTH.html The increase in size or mass of the heart. 32/43 Gene Ontology BP GO:0060419 0.00568518514857643 0.0134540021460564 2340 1821.63636363636 1666 0.000518175457696259 477 1.20329759386348 1.31242156243682 1 7.68726309982005 2337 984 991 1829 1089 2820 2745 477 3979 1666 1121 1427 M16470 GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 33/42 Gene Ontology BP GO:0090314 0.000138302700748136 0.000964772059454575 2710 1444 1667 1.25737632630803e-05 123 0.96102386952233 -0.741279203627963 -1 9.89758294004416 2710 260 2624 208 156 681 1667 3098 123 2544 1813 1428 M16787 GO_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). 92/155 Gene Ontology BP GO:0003014 7.25789374586085e-05 0.000588256948185597 2280 1463.18181818182 1667 6.59830290720708e-06 302 1.2941780597859 1.24750514487802 1 14.2831200833498 2278 805 331 1961 1809 2218 2402 732 1590 302 1667 1429 M10337 GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-5 production. 16/42 Gene Ontology BP GO:0032674 0.000723755942850935 0.00316304618675034 4475 2248.36363636364 1669 6.58176503438828e-05 345 1.50321189892191 -1.37851800474374 -1 12.8373008472143 4471 1150 1669 605 345 4049 3827 2307 488 1399 4422 1430 M12332 GO_CARDIAC_ATRIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_ATRIUM_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. 31/55 Gene Ontology BP GO:0003230 0.029429901743431 0.0485421243573854 1010 1987.09090909091 1669 0.00271192062406588 1006 1.17171760153826 1.20218673802105 1 5.25279907624751 1006 3435 2521 3416 1259 1669 1379 1607 1066 2773 1727 1431 M13032 GO_EMBRYONIC_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PATTERN_SPECIFICATION.html The process that results in the patterns of cell differentiation that will arise in an embryo. 67/93 Gene Ontology BP GO:0009880 0.00552871401010863 0.0134540021460564 1160 1737.18181818182 1669 0.000503877912274458 705 1.38789395223309 1.3271199452558 1 8.86819214318491 1896 1528 705 2616 1159 2026 1156 3323 1811 1220 1669 1432 M15479 GO_NEGATIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. 272/388 Gene Ontology BP GO:0007162 4.95428131550997e-10 2.2165645154873e-08 1670 1601.27272727273 1669 4.50389210602332e-11 67 1.31107954399358 1.36784448761543 1 34.2999166250397 1669 1376 74 1198 1937 2582 2981 773 2486 67 2471 1433 M12897 GO_RESPONSE_TO_GROWTH_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 34/67 Gene Ontology BP GO:0060416 3.392868405915e-05 0.000335904000263133 3985 2051.09090909091 1670 3.08447339299947e-06 75 1.19409386795165 -1.12708121789814 -1 14.171217011411 3982 248 1670 190 75 4323 2925 3489 115 1442 4103 1434 M14317 GO_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. 561/765 Gene Ontology BP GO:0005975 0.00525070999993344 0.0130510436056038 4380 2284.90909090909 1670 0.000526315789473684 10 1.12481998059661 -1.0132286590789 -1 7.23600097733295 4378 597 4486 10 1043 1670 3795 4079 884 533 3659 1435 M12531 GO_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 52/57 Gene Ontology BP GO:0034333 0.0086573907162241 0.0184398493981262 625 1628.63636363636 1671 0.000790149815196695 593 1.06877662116204 1.14879747388956 1 6.3264177024192 622 2641 2541 1329 2683 1671 1984 593 1064 2055 732 1436 M14565 GO_HAIR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hair cell. 41/64 Gene Ontology BP GO:0035315 0.00980217861766001 0.0202979693404415 1675 1666.36363636364 1671 0.000895102450827318 344 1.37374744502753 1.21851158247664 1 7.93884354065853 1671 2676 2377 2942 903 613 344 2579 1029 2013 1183 1437 M14634 GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. 3/19 Gene Ontology BP GO:0021527 0.00228294276224649 0.007153220655039 3750 2368 1671 0.000228529148133085 12 1.71817111125949 -2.33482850544961 -1 12.5927169567692 3746 1251 4506 1200 559 3221 1035 4533 12 1671 4314 1438 M15710 GO_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLATION.html The covalent attachment and further modification of carbohydrate residues to a substrate molecule. 226/292 Gene Ontology BP GO:0070085 0.0845066319193468 0.116103830570851 4370 2285.90909090909 1671 0.0079944330846143 680 1.19245712998828 -1.10158925418817 -1 3.80190942719931 4367 680 1671 703 1668 2371 3839 4517 939 1031 3359 1439 M10650 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. 27/55 Gene Ontology BP GO:0032731 0.0348348087229793 0.0556042418483782 2075 1843.63636363636 1672 0.00321808443257908 913 1.4785675853267 1.66815071785979 1 6.33299838500396 2071 1672 1529 2122 2070 2436 1650 1110 913 1254 3453 1440 M12951 GO_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. 37/52 Gene Ontology BP GO:0045445 0.00577426225782821 0.0134540021460564 2620 1759.72727272727 1672 0.000526315789473684 202 1.28088611338401 1.34838092347448 1 8.18362465831849 2617 1615 1390 202 1672 2379 948 2643 2960 1687 1244 1441 M13461 GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of dendrite development. 91/107 Gene Ontology BP GO:1900006 0.0108580404639333 0.02199497704775 1315 1628 1672 0.000992000296699289 799 1.07939177451947 1.2425644684254 1 6.10679951862043 1315 799 2050 871 928 1672 2163 2367 2146 2167 1430 1442 M11027 GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION.html The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 14/25 Gene Ontology BP GO:0021694 0.016712596093634 0.030809710627448 1395 1894.54545454545 1674 0.00153099295082851 798 1.23475155757326 1.2772186193912 1 6.36941895714838 1391 2350 1895 2355 1674 1234 910 798 4315 1629 2289 1443 M11177 GO_REGULATION_OF_BODY_FLUID_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BODY_FLUID_LEVELS.html Any process that modulates the levels of body fluids. 509/777 Gene Ontology BP GO:0050878 1.16914320564697e-08 3.6266822239169e-07 800 1788.45454545455 1675 1.169143211798e-09 55 1.31416039465557 1.24372244952482 1 28.9267524301116 798 1330 4283 2252 2077 1357 1675 1157 2777 55 1912 1444 M13019 GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION.html The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. 14/25 Gene Ontology BP GO:0021702 0.0119909550674478 0.0237623142797421 1395 1886.72727272727 1675 0.0010960740066954 701 1.23475155757326 1.2772186193912 1 6.84560515313493 1392 2351 1896 2356 1675 1235 911 701 4316 1631 2290 1445 M15470 GO_CELLULAR_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 294/401 Gene Ontology BP GO:1901653 0.0274643059204629 0.0460841743411157 1225 1710.72727272727 1677 0.0025284798815374 657 1.07651333507804 1.10547817379757 1 4.90819155253177 1224 657 1749 1785 3967 1971 1632 1585 1677 675 1896 1446 M10636 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. 53/89 Gene Ontology BP GO:0032757 0.0378017910671166 0.0594630607962452 965 2014.36363636364 1679 0.00349703572746847 962 1.26172126964706 1.27307572751742 1 5.27693872343853 962 3364 1199 3438 1679 1422 1531 1141 3088 2115 2219 1447 M16798 GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. 75/83 Gene Ontology BP GO:0007266 0.0437034563036383 0.0667624029745713 980 1506.81818181818 1679 0.00405423402886751 97 1.23829552217735 1.19369080222434 1 4.96587778820394 979 97 1060 579 2732 1679 1928 2484 1742 1154 2141 1448 M10840 GO_ICOSANOID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_TRANSPORT.html The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. 20/31 Gene Ontology BP GO:0071715 0.00359460414342609 0.00999246212739869 1685 1564.63636363636 1681 0.000327317352431857 360 1.45785989010716 -1.58672444661877 -1 9.95966208932926 1681 1098 694 1744 769 2690 2025 360 3269 982 1899 1449 M16736 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS.html Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. 51/76 Gene Ontology BP GO:0021955 0.0188366853754386 0.0338536489192413 810 2065.18181818182 1681 0.00172726615328676 365 1.09738221006941 1.1134167276558 1 5.50609872619939 806 3363 1681 3828 4161 813 365 1122 4109 1988 481 1450 M13620 GO_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 108/167 Gene Ontology BP GO:0032368 0.0280593481457892 0.046879765501744 1180 1912.63636363636 1682 0.00258397705537128 696 1.22303496973921 1.29761854506014 1 5.54660132812821 1178 2567 968 3958 1868 1125 696 1682 3584 1491 1922 1451 M13716 GO_FATTY_ACID_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_TRANSPORT.html The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/31 Gene Ontology BP GO:1901571 0.0039574439946133 0.0107182694452478 1685 1568.09090909091 1682 0.000360416434138432 386 1.45785989010716 -1.58672444661877 -1 9.80787798165916 1682 1099 695 1745 770 2691 2026 386 3270 985 1900 1452 M14318 GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. 106/121 Gene Ontology BP GO:0032231 0.00577426225782821 0.0134540021460564 1565 1739.45454545455 1682 0.000526315789473684 40 1.07909924498631 1.10337988313448 1 6.89272176313054 1563 40 1643 195 3641 1682 2422 2451 2723 750 2024 1453 M11091 GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme adenylate cyclase. 25/45 Gene Ontology BP GO:0007190 0.00209671111620229 0.00671610900661189 2075 1724.72727272727 1683 0.000190792005282092 276 1.28844924885943 1.12949404673042 1 9.56118824054621 2074 1683 1505 402 3766 2901 2361 276 790 2337 877 1454 M14239 GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. 155/300 Gene Ontology BP GO:0051480 3.84032745283455e-09 1.37454181831071e-07 1770 1818.90909090909 1684 3.49120678139841e-10 95 1.36114931110661 1.31937472762035 1 31.9222769807837 1767 1423 95 1521 4594 2003 2015 1684 3408 385 1113 1455 M11910 GO_FOREBRAIN_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_REGIONALIZATION.html The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. 12/33 Gene Ontology BP GO:0021871 6.02773546746404e-05 0.000512371815338061 3685 1873.81818181818 1685 5.47990966045749e-06 106 0.963037542259412 -0.94910216085903 -1 10.8232736255824 3683 514 2644 1353 106 4246 3285 341 178 2577 1685 1456 M12061 GO_GLYCEROLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. 316/425 Gene Ontology BP GO:0046486 0.00399693445823871 0.0108063544649534 4485 1954.36363636364 1686 0.000364019506007504 14 1.12215324141513 -1.11850989222508 -1 7.53328995878794 4484 634 651 14 1852 2387 4292 4013 856 629 1686 1457 M12094 GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 37/59 Gene Ontology BP GO:0051281 0.000902444588365737 0.00368339883304015 4625 2082.81818181818 1686 8.20740896134901e-05 237 1.13962097056531 -1.27207761758643 -1 9.47197233210107 4624 237 1297 540 387 3066 4136 2552 517 1686 3869 1458 M10256 GO_CARBOHYDRATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORT.html The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. 85/126 Gene Ontology BP GO:0008643 0.0883792254417261 0.120771963577196 4295 2341.45454545455 1687 0.00837664535642459 686 1.15635310666794 -1.13178881806519 -1 3.61879375011994 4294 1487 2139 1002 1687 3048 4045 4619 686 1173 1576 1459 M14290 GO_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. 44/63 Gene Ontology BP GO:0006939 0.00103261000494241 0.00406491908036975 795 1791.27272727273 1690 9.39177270865105e-05 339 1.57193456510387 1.62873948786637 1 12.8391568107786 791 2666 506 2787 3940 2536 1690 339 3036 951 462 1460 M12834 GO_FEAR_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEAR_RESPONSE.html The response of an organism to a perceived external threat. 23/47 Gene Ontology BP GO:0042596 0.000268064486625799 0.00156499881589692 2560 1532.45454545455 1691 2.43724686531504e-05 48 1.99648514707513 -1.54670015413262 -1 19.1392414001764 2559 1691 1314 985 1779 2664 2436 68 48 1274 2039 1461 M14306 GO_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JNK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. 203/282 Gene Ontology BP GO:0046328 0.0543839291328433 0.0801039639933903 1390 1869 1691 0.00507061327722281 706 1.07351683763361 1.05296859419084 1 4.01325330566392 1389 1390 1956 849 3753 1352 706 2431 2554 1691 2488 1462 M16799 GO_RESPONSE_TO_LEPTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEPTIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. 23/27 Gene Ontology BP GO:0044321 0.0120496575234878 0.0238279032965528 2185 1793.81818181818 1691 0.00110146958643966 375 1.1010096293827 1.09850156632077 1 6.09846332249217 2183 375 2323 2679 961 1629 1691 1136 3377 2613 765 1463 M15968 GO_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. 124/190 Gene Ontology BP GO:0048593 2.82703033434209e-05 0.000291666788152855 2265 1703.18181818182 1692 2.57006060247749e-06 138 1.24739709500359 1.12026665731758 1 15.0658343584451 2265 752 291 138 2713 2221 2123 1580 1692 623 4337 1464 M14976 GO_FEMALE_MEIOTIC_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_MEIOTIC_DIVISION.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. 24/32 Gene Ontology BP GO:0007143 0.0356631642491038 0.056738973097512 1940 2121.81818181818 1694 0.00329588666745494 1140 1.13836147813977 -1.34591111325587 -1 4.83922807784294 1938 1694 3030 1557 1331 1466 1140 3600 1510 3529 2545 1465 M15307 GO_DOPAMINERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. 27/46 Gene Ontology BP GO:0071542 0.028473187172684 0.0474179455671076 3250 2371.90909090909 1694 0.00262259235600122 681 1.41129200513047 1.4014309598955 1 6.37808981163302 3250 1662 1228 1694 1540 4249 4623 2248 930 681 3986 1466 M16906 GO_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS.html The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. 123/161 Gene Ontology BP GO:0042476 3.87890373473556e-10 1.8416876609923e-08 460 1698.54545454545 1694 3.5262761231086e-11 71 1.41848210269862 1.45547348741235 1 37.5008405394321 460 2557 71 2094 4234 1780 1694 1357 2931 277 1229 1467 M12329 GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 17/22 Gene Ontology BP GO:0098911 0.0142411513811329 0.0271574087608243 4170 1988 1695 0.00130310746534826 585 1.41094735611721 -1.81231219668706 -1 7.54418912562194 4166 1111 1695 585 2381 1545 3311 757 2369 1478 2470 1468 M14425 GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. 64/76 Gene Ontology BP GO:0009168 0.0329859148214489 0.0530900939689387 305 1879.54545454545 1696 0.00304464815517864 303 0.679898004908356 -0.675156130346751 -1 2.95308866281782 303 1530 3991 2154 1793 546 770 1078 2602 4212 1696 1469 M12209 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 20/30 Gene Ontology BP GO:0010523 0.000338044002788003 0.00185924201533402 4655 2255.27272727273 1697 3.07359960524759e-05 242 1.14766949257655 -1.13402592556606 -1 10.7039759597914 4652 1069 1483 1135 242 1697 3191 1081 3308 2353 4597 1470 M15156 GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 64/76 Gene Ontology BP GO:0009127 0.036106480666281 0.0573195000137173 305 1884.54545454545 1697 0.00333754955734418 304 0.679898004908356 -0.675156130346751 -1 2.87570743419883 304 1531 3992 2155 1794 547 771 1123 2603 4213 1697 1471 M14747 GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein depolymerization. 23/30 Gene Ontology BP GO:1901881 0.0995570238909921 0.133229459926599 1920 1927.54545454545 1699 0.00948819495173019 1164 1.01822942884236 1.04930663820239 1 3.03684257596713 1918 1699 2670 1555 2646 1164 1922 1611 3215 1276 1527 1472 M10396 GO_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or around a point. 80/126 Gene Ontology BP GO:0009798 0.102300804677066 0.136483212344579 1130 2222.09090909091 1700 0.00976296060561287 1032 1.25439851254755 1.15846868859019 1 3.69874241398235 1129 3332 1496 3103 4557 1429 1298 3488 1700 1879 1032 1473 M10726 GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 14/24 Gene Ontology BP GO:0070168 0.000207911310139742 0.00129853869272513 1635 2031.72727272727 1702 1.89028146752248e-05 191 1.1781300151734 1.3217149864924 1 11.6162385613324 1634 3224 1738 4339 191 1702 2365 770 4039 1627 720 1474 M12832 GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. 37/61 Gene Ontology BP GO:0034123 0.00610813028164759 0.0140212778492877 985 1879.81818181818 1702 0.000556832295175797 495 1.24100639034252 1.31246189904081 1 7.85239805310893 983 3083 1586 3372 1857 1620 1702 495 2171 2434 1375 1475 M16882 GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. 18/22 Gene Ontology BP GO:0000737 0.00492400972294916 0.0124586281897131 1705 2259.72727272727 1702 0.000448642293754009 125 0.8976536736236 -0.990719326885915 -1 5.83439756715056 1702 4186 3624 3775 1187 1511 2201 1560 1383 3603 125 1476 M11366 GO_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_ASSEMBLY.html The aggregation, arrangement and bonding together of the extracellular matrix. 21/22 Gene Ontology BP GO:0085029 0.0221534283871946 0.0385036022134923 1125 2210.18181818182 1703 0.00203451855530887 925 1.41003658782074 1.53336990656513 1 6.80841014985864 1125 3841 925 3532 1169 1981 1703 1311 4440 1089 3196 1477 M14398 GO_CELLULAR_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, as carried out by individual cells. 802/1131 Gene Ontology BP GO:0044255 1.04522337134398e-06 1.77497238936625e-05 3695 2049.63636363636 1703 1.04522386296565e-07 3 1.15262863882866 -1.09255738937279 -1 18.7112121449064 3694 584 4491 3 1662 1703 4154 2984 1010 110 2151 1478 M16913 GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 225/273 Gene Ontology BP GO:0010770 0.000386139847392304 0.00201424743264169 810 1771.63636363636 1704 3.51097853261874e-05 433 1.17330055163777 1.23368745111882 1 10.8037615755113 809 1965 433 2410 3331 1411 1704 2987 3006 494 938 1479 M10928 GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 22/28 Gene Ontology BP GO:0015986 0.00238803357002787 0.00734754956122551 250 1947.45454545455 1705 0.000217329968579782 202 0.481469910593861 -0.49016721430493 -1 3.50192335019891 249 1705 3839 2609 553 542 202 1677 3761 4459 1826 1480 M10051 GO_GLUCURONATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. 9/28 Gene Ontology BP GO:0019585 0.0023673393394004 0.00732395608126999 510 1776.09090909091 1706 0.000236986506007041 294 1.15827156400554 1.39115055286254 1 8.44509263250434 510 1235 4220 1770 3044 1706 294 306 2272 2872 1308 1481 M11634 GO_THIOESTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 77/99 Gene Ontology BP GO:0035383 0.000250682285353206 0.00148400085718634 3495 2246.90909090909 1706 2.27918958434663e-05 80 1.0074277402529 1.10034661791403 1 9.73188664255302 3495 80 1706 1171 210 3766 4036 3244 1683 833 4492 1482 M12725 GO_RESPONSE_TO_INSULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSULIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 242/299 Gene Ontology BP GO:0032868 0.201955765635478 0.245480715125883 1215 1680.09090909091 1706 0.020299430757366 326 1.03844526799203 1.08685275985845 1 2.15501329339379 1214 669 2179 326 3692 1830 1715 2409 1573 1168 1706 1483 M12843 GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. 22/28 Gene Ontology BP GO:0015985 0.00238803357002787 0.00734754956122551 250 1939.81818181818 1706 0.000217329968579782 203 0.481469910593861 -0.49016721430493 -1 3.50192335019891 250 1706 3840 2610 554 543 203 1520 3762 4523 1827 1484 M15928 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 18/27 Gene Ontology BP GO:0030949 5.6862206745155e-05 0.000494541771934965 1235 1620.36363636364 1706 5.16942513499584e-06 100 1.38613783632347 1.54824376055267 1 15.6559467796861 1235 1741 960 1846 100 2481 1706 675 3747 2141 1192 1485 M14675 GO_URONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. 9/28 Gene Ontology BP GO:0006063 0.00267664427518188 0.0080092770497886 515 1805.72727272727 1707 0.000267987374220463 295 1.15827156400554 1.39115055286254 1 8.29125349363281 511 1236 4510 1771 3045 1707 295 324 2273 2882 1309 1486 M15311 GO_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 77/99 Gene Ontology BP GO:0006637 0.000250682285353206 0.00148400085718634 3500 2241.18181818182 1707 2.27918958434663e-05 81 1.0074277402529 1.10034661791403 1 9.73188664255302 3496 81 1707 1172 211 3767 4037 3171 1684 834 4493 1487 M10384 GO_INTERMEDIATE_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. 51/72 Gene Ontology BP GO:0045103 0.0713137639109944 0.100674436734787 1165 2017.81818181818 1708 0.00670328127644686 1164 1.85517608893845 -2.1640042233981 -1 6.31357088665452 1164 3038 1178 2019 1634 1708 1932 2877 3741 1657 1248 1488 M14974 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. 11/20 Gene Ontology BP GO:0032691 0.000295437636099175 0.00169441789232652 1205 1962.72727272727 1709 2.68615743482776e-05 222 1.0963835666965 1.14784570086847 1 10.3762920854737 1202 3242 2477 2043 222 2475 1709 4476 1082 1237 1425 1489 M14992 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 1393/1992 Gene Ontology BP GO:0048585 3.97393680963892e-08 1.12748341312499e-06 1370 2038.54545454545 1709 3.97393688070369e-09 66 1.1800203767155 1.25793376640373 1 23.9856680512515 1369 1267 4528 1709 3691 1994 2301 1501 2447 66 1551 1490 M10892 GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. 55/70 Gene Ontology BP GO:0032272 0.208220611485714 0.252173478720205 2930 2019.36363636364 1710 0.0210011102617088 870 1.08919377018157 -1.03223012024136 -1 2.21734655155305 2927 870 2847 1052 3248 1710 3059 2488 1197 1326 1489 1491 M15957 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. 55/133 Gene Ontology BP GO:0002440 0.0241304952937469 0.0413703738400163 710 2043.54545454545 1710 0.00221811866757934 424 1.19006962634282 1.29945376012236 1 5.61773109657499 708 3358 1710 2592 4048 1264 424 1072 3940 1585 1778 1492 M14180 GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 82/97 Gene Ontology BP GO:0009124 0.0294993813752496 0.0485878306332873 245 2056 1711 0.00271841104219373 245 0.730234179528966 -0.718086694211523 -1 3.26859502531599 245 1501 4048 2605 4072 405 638 1329 1857 4205 1711 1493 M12973 GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. 10/13 Gene Ontology BP GO:0060576 0.00118929496693754 0.00447355657329051 4140 2082.63636363636 1712 0.000108176215751104 94 1.19973864656868 -1.30952057278034 -1 9.62599079495839 4137 1211 1712 97 424 3873 4375 3671 94 1084 2231 1494 M13986 GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. 52/88 Gene Ontology BP GO:0043471 0.030377206548807 0.0496819480040769 1920 1736.45454545455 1712 0.00280044921003047 812 1.03772588418794 1.05104037210053 1 4.61513356097951 1920 1567 2629 1931 1919 1712 1707 1029 812 2390 1485 1495 M16356 GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. 52/88 Gene Ontology BP GO:0043470 0.0578546191689894 0.0842822614255816 1925 1766.63636363636 1713 0.00540313972164104 813 1.03772588418794 1.05104037210053 1 3.80075030723033 1921 1568 2630 1932 1920 1713 1708 1351 813 2391 1486 1496 M11296 GO_INORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSPORT.html The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 81/147 Gene Ontology BP GO:0015698 0.0132002255587636 0.0256132817034725 3830 2313.90909090909 1714 0.00120728182121434 824 1.39845131432183 -1.30608064869146 -1 7.59883339248884 3829 824 830 1714 1457 4577 3628 1245 1166 1932 4251 1497 M13033 GO_RESPONSE_TO_PROTOZOAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROTOZOAN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. 15/25 Gene Ontology BP GO:0001562 0.00857186623301518 0.0182958227441374 1590 1861.54545454545 1714 0.000782313467866148 553 1.17070568973676 -1.5182934115152 -1 6.94441462117769 1586 1169 1714 553 869 2440 3388 3127 665 2912 2054 1498 M10591 GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. 250/338 Gene Ontology BP GO:0070302 0.00577426225782821 0.0134540021460564 1715 2036 1715 0.000526315789473684 169 1.0644013689577 1.09394273038043 1 6.79869418408583 1715 1379 1647 169 4603 2249 1385 2631 2367 1360 2891 1499 M11276 GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. 23/32 Gene Ontology BP GO:1901385 0.10557573154256 0.139955521044881 1085 1948.18181818182 1718 0.0100919171225041 1058 1.11172285940012 1.14142923593629 1 3.23536249071964 1081 1698 2123 2997 2367 1480 1718 2414 2821 1673 1058 1500 M11959 GO_HEXOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 54/78 Gene Ontology BP GO:0019320 0.0222591928629129 0.0386462777578857 3120 2006.81818181818 1718 0.00204433181497257 621 1.1463937136086 -1.05877301337368 -1 5.52711192778516 3120 1557 2062 1465 1163 2814 4064 1718 621 1280 2211 1501 M15328 GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 10/18 Gene Ontology BP GO:0060457 0.0494449238211822 0.0739053101638164 2190 1826.81818181818 1718 0.00459931554189792 681 1.20427509809589 1.00199461001168 1 4.64739921288934 2189 1232 1493 1778 1718 1973 981 1558 4169 2323 681 1502 M13981 GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphatidylinositol. 21/23 Gene Ontology BP GO:0046856 0.00104848671292966 0.00410657295897451 1935 1828.81818181818 1720 9.53624308628982e-05 23 0.985560418998667 -1.21359255412548 -1 8.03090698777845 1935 1720 3450 643 405 2346 3518 1305 23 3746 1026 1503 M11624 GO_RESPONSE_TO_MURAMYL_DIPEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MURAMYL_DIPEPTIDE.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. 20/24 Gene Ontology BP GO:0032495 0.00243267187678844 0.0074419607118321 1010 1811.90909090909 1721 0.000221396909045854 558 1.03934969530794 1.15103379801395 1 7.55225770152448 1008 1721 2134 2107 558 1157 1296 4163 1364 1841 2582 1504 M13136 GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus. 26/29 Gene Ontology BP GO:2001273 0.00139935663847437 0.00507498553298615 2335 1504.45454545455 1721 0.000127295229305679 320 0.923982799065454 -0.687346339295513 -1 7.23798015280317 2333 320 1721 1114 452 1756 1953 1924 1644 2413 919 1505 M14996 GO_DEVELOPMENTAL_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_CELL_GROWTH.html The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. 102/120 Gene Ontology BP GO:0048588 0.108266272018034 0.143114478323838 1090 2123.72727272727 1723 0.0103629941385921 1041 1.08776195208006 1.14067374732255 1 3.12935080059027 1090 2992 1723 3352 1804 1041 1147 1658 3941 3049 1564 1506 M10588 GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. 46/54 Gene Ontology BP GO:0030517 0.00134304379974157 0.00492837760267945 1270 1795 1725 0.00012216949046288 532 1.49867396275597 1.53729981286521 1 11.811662339528 1269 2655 532 2283 1788 3534 1725 1392 2420 651 1496 1507 M11754 GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. 52/91 Gene Ontology BP GO:1904063 0.110453043440651 0.145426715090364 2435 2307.18181818182 1725 0.010583863776154 1036 1.0527722207898 1.00898198095899 1 3.00329299699969 2435 1551 1523 1367 3124 2804 1036 4550 1345 1725 3919 1508 M15236 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI.html The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. 77/82 Gene Ontology BP GO:0042147 0.12021628578451 0.156597530166665 955 2201.81818181818 1725 0.0115760379709949 866 0.801256752140645 0.791275830734445 1 2.19518751067193 955 2601 4064 3617 2308 1001 1213 1725 866 4288 1582 1509 M10663 GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. 23/30 Gene Ontology BP GO:0006656 0.00577426225782821 0.0134540021460564 3200 2036.81818181818 1726 0.000526315789473684 35 1.39117772645777 -1.3961605581657 -1 8.88919962344087 3198 1034 1403 35 4387 3567 3198 1726 114 656 3087 1510 M10772 GO_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ASSEMBLY.html Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. 308/403 Gene Ontology BP GO:0030031 0.199625160802529 0.243219657819892 2995 2074.36363636364 1726 0.0200396741903753 257 1.06175042572924 -1.08910338151474 -1 2.21820434623523 2992 639 2028 257 3529 1256 3185 4495 1049 1726 1662 1511 M12337 GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS.html The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. 218/269 Gene Ontology BP GO:0015980 0.0608238613809791 0.0879743322989418 635 1939.63636363636 1726 0.00568850757409503 631 0.743885117462628 -0.670243559824132 -1 2.67416100210521 631 674 4079 1726 1524 771 1574 1754 1990 4291 2322 1512 M12510 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. 134/170 Gene Ontology BP GO:0033135 0.0684904350822854 0.0973681620647338 1405 1745.36363636364 1726 0.00642913688059094 1199 1.1409203408194 1.26713808883002 1 3.93526633093731 1404 2038 1726 2439 2163 1775 1839 1421 1496 1699 1199 1513 M12264 GO_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CONTRACTION.html A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. 118/194 Gene Ontology BP GO:0006941 0.0313412950794801 0.0508590954257191 485 1851.90909090909 1727 0.00289062705425418 485 1.09096047533464 1.0928904393022 1 4.81450007040101 485 2049 1377 2336 3106 1727 1293 1537 3588 2387 486 1514 M14082 GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 22/44 Gene Ontology BP GO:0044058 0.00842086866981466 0.0180646850717601 1430 2075.90909090909 1727 0.000768479522262043 587 1.22070043404179 1.09969892604302 1 7.26447400517028 1429 1727 1264 2992 3493 2111 1422 587 4086 2061 1663 1515 M15406 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 1207/1669 Gene Ontology BP GO:0051094 4.10519740143204e-10 1.91014835088633e-08 1025 1953.18181818182 1727 4.10519740219041e-11 34 1.24551112318263 1.27226807426213 1 32.8591547861003 1022 1879 4553 1711 3482 1233 1727 2115 2250 34 1479 1516 M15924 GO_MODULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 303/448 Gene Ontology BP GO:0050804 9.37619648635079e-08 2.28415928015656e-06 1730 1847.90909090909 1728 8.52381535086874e-09 99 1.3190309388974 1.2214095941825 1 25.4297740722259 2573 1942 143 99 1728 1726 2080 4222 1726 106 3982 1517 M10677 GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of dendritic cell differentiation. 26/50 Gene Ontology BP GO:2001198 0.0437101810368973 0.0667624029745713 195 2376.36363636364 1729 0.00405487071716719 194 0.845017173084827 -0.862877473879188 -1 3.38534583380451 194 4460 3138 3944 1404 580 1178 1729 4400 3606 1507 1518 M15177 GO_INTRACELLULAR_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIPID_TRANSPORT.html The directed movement of lipids within cells. 37/57 Gene Ontology BP GO:0032365 0.00218524317337154 0.00692167221626804 3245 1876.27272727273 1729 0.000198856071085757 69 1.19337596687577 -1.24286322690996 -1 8.80146986181676 3242 222 1791 161 1729 3316 3964 3088 1368 1689 69 1519 M10329 GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. 78/108 Gene Ontology BP GO:0009132 0.027133428296956 0.0456112145468701 1515 1739.63636363636 1730 0.00249763362154718 373 1.04191109065702 -1.03674595957264 -1 4.76604483593027 1513 2104 3043 2495 2188 373 815 1382 1730 2295 1198 1520 M14856 GO_MYELIN_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_ASSEMBLY.html The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. 25/30 Gene Ontology BP GO:0032288 0.0525205942336442 0.07772847486296 3570 2142.81818181818 1730 0.00489254483028249 743 1.32568040337083 -1.44879435803629 -1 5.01770680298732 3569 1027 1730 760 3499 2450 4440 1307 1702 2344 743 1521 M12011 GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION.html Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. 14/24 Gene Ontology BP GO:0071675 0.00173322442838067 0.00591253171939534 605 1906.09090909091 1731 0.000157690129211054 240 1.39111114877132 1.48169593877926 1 10.5870852108261 601 3560 1174 3019 2258 1755 1731 240 4035 1141 1453 1522 M13853 GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. 15/23 Gene Ontology BP GO:0048642 0.00238383425563148 0.00734568264334653 395 1896.27272727273 1731 0.000216947382795126 296 1.24588830815042 -1.35773216107034 -1 9.07924336434754 1335 3210 1731 3719 2952 393 694 296 4373 1765 391 1523 M15620 GO_PROTEIN_CHROMOPHORE_LINKAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHROMOPHORE_LINKAGE.html The covalent or noncovalent attachment of a chromophore to a protein. 6/12 Gene Ontology BP GO:0018298 0.0896584380459792 0.122232480868365 2185 2136.72727272727 1732 0.00934955922696838 968 1.54563987537166 1.80294296038019 1 4.81306430527725 2182 2426 4563 1013 1732 1304 1001 3609 968 1575 3131 1524 M16907 GO_CORPUS_CALLOSUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORPUS_CALLOSUM_DEVELOPMENT.html The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. 24/36 Gene Ontology BP GO:0022038 0.0154976872967804 0.0290300881609981 605 1854.45454545455 1733 0.00141890438295984 310 1.04505967583377 1.07386003952998 1 5.48158630493675 605 2757 2124 1436 1733 420 310 3382 3829 2693 1110 1525 M14125 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that activates or increases the frequency, rate or extent of response to wounding. 152/245 Gene Ontology BP GO:1903036 2.45850714755499e-10 1.25708063270037e-08 1645 1779.18181818182 1734 2.23500649802703e-11 65 1.52009402633667 1.54070586141617 1 41.0499069010784 1645 2534 65 502 1415 2879 2319 1734 3152 108 3218 1526 M12157 GO_STARTLE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STARTLE_RESPONSE.html An action or movement due to the application of a sudden unexpected stimulus. 19/45 Gene Ontology BP GO:0001964 0.0139777616873688 0.0267428146099206 1790 1577.45454545455 1735 0.00127885162271742 325 2.00652141560303 1.71953113374883 1 10.7789970860395 1790 2806 1190 1025 1010 2182 1951 2504 325 1735 834 1527 M10238 GO_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_SECRETION.html The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. 32/54 Gene Ontology BP GO:0014047 0.1124571577934 0.147856217918251 2515 1842.54545454545 1736 0.0107867184804539 983 1.18443885605755 1.03285878205785 1 3.35110016091716 2513 983 1736 2772 2103 1160 1047 2170 1018 1664 3102 1528 M12354 GO_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMOPOIESIS.html Any process that modulates the frequency, rate or extent of hemopoiesis. 319/511 Gene Ontology BP GO:1903706 0.0056044830338368 0.0134540021460564 900 2113.36363636364 1736 0.000510801049065428 540 1.15752710877729 1.19365480268953 1 7.39445290765496 896 3960 706 3506 3440 1736 1622 1435 3281 540 2125 1529 M13613 GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. 19/24 Gene Ontology BP GO:0070884 0.00577426225782821 0.0134540021460564 3690 2079.09090909091 1736 0.000526315789473684 204 0.988120712368416 -0.708125360476444 -1 6.31069949335172 3687 384 1696 204 1383 4355 4121 1806 850 1736 2648 1530 M16562 GO_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. 1469/2129 Gene Ontology BP GO:0009888 1.01761153758154e-18 9.46989296873381e-16 1565 2119.09090909091 1736 1.01761153758155e-19 1 1.26671687415278 1.2461825650837 1 65.0543580332398 1564 1263 4635 680 3827 2697 2522 1736 2851 1 1534 1531 M10522 GO_RESPONSE_TO_MUSCLE_STRETCH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_STRETCH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. 27/33 Gene Ontology BP GO:0035994 0.0223840736856995 0.0388341144144519 610 2246.18181818182 1737 0.00205592000982137 583 0.905883983204036 1.066562436955 1 4.3587827166497 606 4127 2781 4333 1164 1208 583 1737 4188 2499 1482 1532 M11127 GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of endothelial cell differentiation. 31/40 Gene Ontology BP GO:0045601 0.0023275808725636 0.00723946109628236 1355 1947.72727272727 1737 0.000211822462417292 548 1.45680994251366 1.22722394680376 1 10.6496194083437 1354 2713 951 2864 548 1516 1737 2351 3674 1245 2472 1533 M11440 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. 347/433 Gene Ontology BP GO:0030111 0.14334160187232 0.181933571607176 1310 1673.27272727273 1738 0.0139666433806307 630 1.09747604728787 1.14150231971105 1 2.7663018007887 1310 630 1370 819 3101 2015 2049 2061 1738 1361 1952 1534 M13701 GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of B cell apoptotic process. 19/27 Gene Ontology BP GO:0002902 0.00160549094695868 0.00562526308448699 1160 2063.18181818182 1738 0.000146060343844713 68 0.735212999677423 0.873597801908438 1 5.64470097644522 1158 1738 2988 3734 2686 527 68 229 4244 4028 1295 1535 M14007 GO_MICROTUBULE_BUNDLE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BUNDLE_FORMATION.html A process that results in a parallel arrangement of microtubules. 84/140 Gene Ontology BP GO:0001578 0.0466336453194385 0.070381560710784 3230 1781.36363636364 1739 0.00433204646808411 303 1.31966871856622 -1.25116274886866 -1 5.18946202337012 3230 814 1078 303 3800 1915 3192 1760 977 787 1739 1536 M14165 GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION.html Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. 39/46 Gene Ontology BP GO:0070570 0.04399467447789 0.0670731390385394 2115 2325.45454545455 1739 0.00408180988574133 1412 1.19511880005619 1.46485138379518 1 4.78411622139855 2114 1609 1739 1686 1412 3842 3871 4302 1441 1862 1702 1537 M12163 GO_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 1461/2167 Gene Ontology BP GO:0009719 1.17490992197488e-13 1.6078987843968e-11 1305 1743.09090909091 1740 1.17490992197494e-14 12 1.22757302040968 1.21953539822469 1 45.2907511077677 1303 570 4349 690 2696 995 1740 2673 1876 12 2270 1538 M15772 GO_NEPHRON_TUBULE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_TUBULE_FORMATION.html The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. 14/25 Gene Ontology BP GO:0072079 0.00304869201822228 0.00886337529943135 225 1730.27272727273 1740 0.000277538637821311 54 1.33320891036509 1.33320891036509 1 9.34453158012158 224 3214 1740 1349 3281 54 158 2742 3162 2800 309 1539 M16001 GO_POSITIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 117/178 Gene Ontology BP GO:0050921 2.18771694284012e-07 4.71270691436809e-06 955 1727.54545454545 1742 1.98883378217309e-08 164 1.37423165396345 1.43672082883997 1 25.0165804417077 954 2561 164 2528 3260 961 1491 2350 2735 257 1742 1540 M12721 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. 28/58 Gene Ontology BP GO:0002686 0.000238730119481482 0.0014407409156256 3440 1818.27272727273 1743 2.17050935367314e-05 205 1.55831764201547 -0.981451459597455 -1 15.1278404681763 3436 981 405 472 3193 3060 3933 1838 205 735 1743 1541 M13615 GO_DIOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. 10/12 Gene Ontology BP GO:0034311 0.0225406593364949 0.0390766348333498 4210 2039 1746 0.00207045212513943 132 1.2735030518409 -1.48380514428781 -1 6.12018618048314 4208 1226 2885 1072 1746 3418 3035 911 132 2320 1476 1542 M16113 GO_MIDGUT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDGUT_DEVELOPMENT.html The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. 18/25 Gene Ontology BP GO:0007494 0.000216923106205353 0.00134042923396216 3505 1705.18181818182 1746 1.97222270984488e-05 195 1.70235562797469 -1.81111537677392 -1 16.7095371337952 3501 1746 709 600 195 2455 2008 2118 1396 556 3473 1543 M10360 GO_BONE_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. 34/39 Gene Ontology BP GO:0061430 0.00595882403662833 0.0137736752322065 65 1988 1748 0.000543184119616903 61 1.31837899659514 1.29591783774463 1 8.37751134312841 61 3433 713 3881 1307 1748 1376 2156 4119 1831 1243 1544 M12247 GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. 13/14 Gene Ontology BP GO:0045898 0.0273961167260039 0.0460029343652458 1645 2589.81818181818 1750 0.00252212212359855 455 0.46179953094715 -0.46179953094715 -1 2.10062278894001 1641 3914 3889 4252 1750 762 455 1181 4416 4503 1725 1545 M15577 GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. 282/364 Gene Ontology BP GO:0006091 0.000470331312852616 0.00232364264403131 570 1895.27272727273 1750 4.27665357872422e-05 288 0.777006436714492 -0.68356848547929 -1 6.98622462644215 569 1370 4083 1750 288 571 1124 1938 2750 4332 2073 1546 M11925 GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 16/23 Gene Ontology BP GO:0071732 0.00594992106001582 0.0137599317555932 1755 2134.09090909091 1751 0.000542370351933719 636 0.808774846765266 0.835635985888877 1 5.13635854729617 1751 2327 2710 3537 776 1295 636 1149 4482 3908 904 1547 M10815 GO_PROTEIN_LOCALIZATION_TO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CILIUM.html A process in which a protein is transported to, or maintained in, a location within a cilium. 29/32 Gene Ontology BP GO:0061512 0.00589981367875578 0.0136699157380001 1690 1951.72727272727 1752 0.000537790460387767 145 0.854593943379463 -0.679790675526137 -1 5.43627849681152 1689 2227 3502 1870 4507 360 331 1661 1752 3425 145 1548 M11609 GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 865/1229 Gene Ontology BP GO:1901701 3.07453101021651e-07 6.24707108757092e-06 935 1848.36363636364 1752 3.07453143558993e-08 89 1.16158348119146 1.18856698033699 1 20.6577503524452 934 1887 4315 1468 2395 1000 1564 2027 2901 89 1752 1549 M15108 GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. 17/19 Gene Ontology BP GO:0002313 0.0312899451050325 0.0508174919978067 1755 1560.09090909091 1752 0.00288582188051273 454 1.0744823980811 0.863954728527167 1 4.74292549375288 1752 454 2097 1619 2101 2374 494 2282 692 2557 739 1550 M11346 GO_APOPTOTIC_CELL_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_CELL_CLEARANCE.html The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. 38/46 Gene Ontology BP GO:0043277 0.0114132947793313 0.022939982984116 940 2228.09090909091 1753 0.00104299445616817 647 1.25525034285658 1.19223826696022 1 7.02507312240883 3820 937 1277 647 940 3335 4304 2394 1071 1753 4031 1551 M16683 GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 18/30 Gene Ontology BP GO:0061213 0.00804839571344724 0.0174409086496302 1460 1684.54545454545 1753 0.000734362849772908 446 1.17452769556814 1.43822751241703 1 7.05057744434162 1460 1753 1820 2630 2553 2401 668 576 1567 2656 446 1552 M10045 GO_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_RHYTHM.html Any biological process in an organism that recurs with a regularity of approximately 24 hours. 143/192 Gene Ontology BP GO:0007623 0.0114669735947472 0.0229982017829133 715 1828.90909090909 1756 0.00104792566038535 256 1.10161168846016 1.01591861876637 1 6.15977544573701 713 2978 2635 2345 4621 384 256 1756 2047 1656 727 1553 M15547 GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. 28/53 Gene Ontology BP GO:0045414 0.00700398269347992 0.0156154918412851 1160 2027.54545454545 1756 0.000638761878702481 539 1.10084257994049 1.22971423589316 1 6.78829308440234 1159 3790 1756 3830 1178 1662 916 539 3444 2173 1856 1554 M16553 GO_SIALYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLATION.html The covalent attachment of sialic acid to a substrate molecule. 12/21 Gene Ontology BP GO:0097503 0.000828605318842162 0.00347029752346767 1530 1871 1756 7.53561425817673e-05 157 1.92090427942401 2.04034786130725 1 16.1429067171836 1530 2383 773 1756 3667 2642 2339 157 1110 1377 2847 1555 M13667 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. 40/49 Gene Ontology BP GO:0061418 0.00415716190348292 0.0110786221860859 860 1685 1758 0.000378639836379055 332 1.05267562377534 1.12303432988515 1 7.02731628304396 858 2186 2993 2939 1758 400 332 394 2884 2968 823 1556 M16539 GO_UTERUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTERUS_DEVELOPMENT.html The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. 16/24 Gene Ontology BP GO:0060065 0.0367351231767726 0.0581389551501779 2930 2146.27272727273 1758 0.00339665927404198 537 1.27810651219468 0.828427821894414 1 5.38834234038292 2929 1149 1758 1127 2961 717 537 1713 3671 2458 4589 1557 M16063 GO_PEPTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 20/24 Gene Ontology BP GO:0043171 3.67986091496518e-05 0.000350151182767545 1760 1927.90909090909 1759 3.34538406192481e-06 84 1.22001006987408 1.38205800406516 1 14.4037663338665 1759 2792 2525 778 84 3199 2362 4433 523 1395 1357 1558 M11098 GO_RESPONSE_TO_TYPE_I_INTERFERON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TYPE_I_INTERFERON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 76/123 Gene Ontology BP GO:0034340 0.0290189314763102 0.0480516327968938 395 1823.36363636364 1760 0.00267353860079256 394 1.00185865820919 -0.952831018344807 -1 4.50488502236937 394 2107 2840 2040 1690 1197 1760 1007 2683 2723 1616 1559 M13601 GO_REGULATION_OF_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS.html Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. 19/27 Gene Ontology BP GO:0042481 4.46814069114547e-06 6.38458271516388e-05 595 1581.63636363636 1760 4.06195433258597e-07 2 1.76098506646353 1.85572422946106 1 25.245440016537 593 3176 618 2273 4187 1762 2225 2 1760 627 175 1560 M10925 GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of neuron differentiation. 374/480 Gene Ontology BP GO:0045666 0.00154254079997395 0.00544984232519271 1765 1906.90909090909 1761 0.000140329402081672 541 1.18273872069171 1.2282872671304 1 9.14277009407621 1761 1932 541 1288 3699 1635 2514 3871 2276 639 820 1561 M11988 GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. 83/117 Gene Ontology BP GO:0030004 0.00496901457659359 0.0125452115164894 885 1765.90909090909 1761 0.00045275212947817 436 1.14783685048499 1.37737166601912 1 7.45165844623426 882 3008 1761 3716 2387 557 614 436 2535 2537 992 1562 M15894 GO_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. 46/67 Gene Ontology BP GO:0048806 0.0380257984268456 0.0597548260993288 4305 2300 1763 0.00351812830310105 763 1.39648464306479 1.26772254791554 1 5.83155363122798 4302 903 1031 1059 1763 2532 4237 3926 763 1064 3720 1563 M12172 GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. 71/92 Gene Ontology BP GO:0001954 0.000819376120512048 0.00345027790836431 125 1908.63636363636 1765 7.45164955633228e-05 32 1.09914514236905 1.0520149800778 1 9.24188320631905 123 3695 1251 3885 3104 47 283 1765 4048 2762 32 1564 M12268 GO_HYALURONAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 37/45 Gene Ontology BP GO:0030212 0.0321523016674876 0.0519278328256101 2305 1848.54545454545 1765 0.00296654929980179 941 1.24167019396128 -0.995948044375533 -1 5.44272684041747 2303 941 992 1765 4561 1770 1329 2012 1251 1342 2068 1565 M11724 GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 157/222 Gene Ontology BP GO:0070304 0.00577426225782821 0.0134540021460564 1770 1901.09090909091 1766 0.000526315789473684 127 1.13066588179937 1.11996292920566 1 7.22261201459077 1766 728 1065 127 4394 2012 1344 3280 1832 949 3415 1566 M15635 GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. 18/22 Gene Ontology BP GO:0000097 0.000672643640933045 0.00300365725648892 1280 1697.36363636364 1766 6.11681261687744e-05 236 1.74657617647445 -2.19379987574651 -1 15.0514270926787 1277 1766 3023 2593 334 1571 2146 497 236 3150 2078 1567 M10849 GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. 21/53 Gene Ontology BP GO:0002701 0.00410859107139916 0.0110059149425563 3310 2148.27272727273 1768 0.000374207650622858 541 1.28836706888282 1.53117833721185 1 8.61569835601368 3310 1075 1768 1852 673 4048 4347 1716 1077 541 3224 1568 M15385 GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 29/49 Gene Ontology BP GO:0045923 0.0103692925387404 0.0212641331788272 1835 1707.81818181818 1769 0.000947135566439607 324 1.00677083162148 1.20258853437257 1 5.74573531542812 1834 324 1769 2099 1715 1247 1836 650 4158 1821 1333 1569 M16437 GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. 10/15 Gene Ontology BP GO:1900121 0.00318991377916188 0.00916780037951835 1770 2198.63636363636 1769 0.000290413494542258 478 0.509442826637553 -0.509442826637553 -1 3.53857868735774 1769 2395 2906 2601 606 1461 1433 478 4526 4637 1373 1570 M11590 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 14/23 Gene Ontology BP GO:0010744 0.0119690670955118 0.0237290452473015 2045 1997.81818181818 1770 0.00109406226941354 769 1.53156539642986 1.37708439804701 1 8.49692464252485 2045 1179 814 1264 2264 2309 1770 4646 1092 769 3824 1571 M10737 GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN.html Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. 9/16 Gene Ontology BP GO:2000047 0.018561028372531 0.0335153739112753 1775 1905.18181818182 1772 0.00187179059858931 136 1.48243474378878 -1.45926087324278 -1 7.46394065067238 1772 3256 4258 2376 1453 2422 2483 977 136 1464 360 1572 M12186 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. 20/35 Gene Ontology BP GO:0051770 0.00449351903939442 0.0116610954212505 75 1953.36363636364 1772 0.000409338492885517 72 1.06964840412639 1.2114582022547 1 7.05940990457848 72 3499 1772 3269 4411 299 177 410 4333 2824 421 1573 M13824 GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. 23/40 Gene Ontology BP GO:0046885 0.000301943956147886 0.00171334783897087 3025 1914.09090909091 1772 2.74532186446217e-05 418 1.50164550645591 -1.86303510243016 -1 14.190904186457 3022 1043 418 1772 833 2244 954 4129 1796 910 3934 1574 M12371 GO_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BEHAVIOR.html Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 48/91 Gene Ontology BP GO:0050795 0.00437461288634877 0.0114702123219346 1840 1847.45454545455 1774 0.000398485084010202 667 1.6071460103965 1.64754520171524 1 10.6515024269175 1836 3051 667 2995 1774 1251 877 3179 2060 939 1693 1575 M12542 GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of glial cell proliferation. 26/29 Gene Ontology BP GO:0060251 0.0491721742145411 0.0735448815879973 1660 1703.90909090909 1774 0.00457335370239647 230 1.32386408467439 1.25446696320578 1 5.11957208424923 1658 1020 2078 895 3598 2247 655 2176 230 2412 1774 1576 M12344 GO_NEPHRIC_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. 20/29 Gene Ontology BP GO:0072176 0.0447182869685268 0.0678429048792159 360 1744.54545454545 1775 0.00415036284210879 358 1.22432647645301 1.20148515769333 1 4.8805519630453 358 2801 1775 2464 1447 900 794 1219 3224 2354 1854 1577 M16433 GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION.html The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. 18/22 Gene Ontology BP GO:0060900 0.106723542418814 0.141275858570339 3665 2364.81818181818 1775 0.0102074704379116 899 1.44745786337892 -1.34273522464429 -1 4.19546589811245 3663 1731 1326 1550 1775 3364 3983 4199 899 1606 1917 1578 M10571 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. 14/23 Gene Ontology BP GO:1901017 0.0407032572226679 0.0630257091038515 1480 2067.18181818182 1776 0.00377058456977355 573 0.931053973284347 1.07338656357157 1 3.81074185571259 1055 2347 2500 3254 1479 1387 573 1776 4107 2784 1477 1579 M13769 GO_MICROGLIAL_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROGLIAL_CELL_ACTIVATION.html The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 25/50 Gene Ontology BP GO:0001774 0.00494424505708486 0.0125030283970738 890 1909.45454545455 1776 0.00045049016018178 434 1.12545186705998 1.11470754414943 1 7.31175764626982 888 3478 1870 2913 1013 1776 469 434 3793 2765 1605 1580 M10614 GO_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 387/549 Gene Ontology BP GO:0001101 6.47483122415996e-12 4.70740463844005e-10 1780 1672.09090909091 1777 5.88621020379912e-13 44 1.24433950961142 1.18738416512826 1 39.6704148103168 1777 624 44 797 1238 2622 2449 2893 3034 96 2819 1581 M13056 GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. 14/38 Gene Ontology BP GO:0071875 9.35404808059272e-05 0.000710022605530146 3580 2190.18181818182 1777 8.50404165766383e-06 136 1.5667513576066 1.09169323261049 1 16.8559400954502 3577 1777 1512 1265 136 3805 2840 3033 163 1632 4352 1582 M13259 GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. 122/178 Gene Ontology BP GO:0032845 0.0699559357090819 0.0990882705797133 1195 1920.09090909091 1779 0.00657134212807701 762 1.06174838897002 1.08809693195303 1 3.6338386210942 1192 762 1779 2539 1639 1961 1217 1433 3832 2086 2681 1583 M12841 GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. 18/19 Gene Ontology BP GO:0007007 0.0419625578790073 0.0647308494484439 590 2118.54545454545 1781 0.00388954497010795 589 0.555429161782202 -0.565314168671549 -1 2.24701677468026 589 2306 3930 2222 1390 1781 957 1753 1435 4522 2419 1584 M11026 GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 15/16 Gene Ontology BP GO:0009070 0.043957242608017 0.067038036661784 1185 1646.45454545455 1782 0.0040782649818828 188 1.34019933433049 -1.54525189362113 -1 5.36721646429446 1181 1782 2175 968 2693 1841 1738 1210 188 2367 1968 1585 M13794 GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. 23/51 Gene Ontology BP GO:0045589 0.0447066514990253 0.0678429048792159 735 2246.54545454545 1782 0.00414926015796936 732 0.876944020178337 -0.789592692402504 -1 3.49275041728791 732 3500 3086 2664 1468 1155 1679 1218 4369 3059 1782 1586 M14261 GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 24/37 Gene Ontology BP GO:0009190 0.0332893583224068 0.0535229385881683 1170 2195.72727272727 1782 0.00307309211243864 508 1.08228223720829 1.04284435700721 1 4.69407768436019 1170 3808 1115 3904 2856 1267 508 1647 4304 1782 1792 1587 M13410 GO_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 40/73 Gene Ontology BP GO:0042116 0.0276738775225579 0.0463189036375762 1045 1988.09090909091 1784 0.00254802225217831 604 1.17903250172708 1.11652046280334 1 5.36773249675026 1044 3076 1438 2887 1604 1784 604 986 3633 2632 2181 1588 M12425 GO_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMOCYTE_AGGREGATION.html The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. 45/63 Gene Ontology BP GO:0071594 0.0366898161398937 0.0581067782501448 2360 1964.18181818182 1786 0.00339239799176823 1079 1.18760969353837 1.25646537481698 1 5.00703994833693 2360 2658 1786 1840 1337 1607 1597 2882 1079 1563 2897 1589 M12683 GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin receptor signaling. 16/20 Gene Ontology BP GO:0046628 0.0311691124770382 0.05067431179443 1845 2137.72727272727 1786 0.00287451564578538 492 0.745006615432576 0.87591179436476 1 3.28842186497058 1843 1786 2728 2693 1369 810 492 1719 4591 3911 1573 1590 M14256 GO_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_IN_THYMUS.html The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. 45/63 Gene Ontology BP GO:0033077 0.0366898161398937 0.0581067782501448 2365 1967.45454545455 1787 0.00339239799176823 1080 1.18760969353837 1.25646537481698 1 5.00703994833693 2361 2659 1787 1841 1338 1608 1598 2908 1080 1564 2898 1591 M14680 GO_RESPONSE_TO_YEAST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_YEAST.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. 11/22 Gene Ontology BP GO:0001878 1.07295672778586e-05 0.000134567861304248 3240 2030.45454545455 1787 9.75419964284665e-07 31 2.57307008416636 -3.06852835584655 -1 34.0437804525492 3236 2398 424 2054 31 1589 1787 4605 1561 798 3852 1592 M16299 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE.html The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. 24/57 Gene Ontology BP GO:0001990 0.0160362169801027 0.0298108340425161 2030 2169.27272727273 1787 0.00146857408645158 830 1.34012014665837 1.45695170216631 1 6.97945029482781 2026 3473 870 3206 1377 3025 1758 830 3874 1787 1636 1593 M11465 GO_NEURAL_RETINA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_RETINA_DEVELOPMENT.html The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. 52/87 Gene Ontology BP GO:0003407 0.00637774659571411 0.01453153638563 1790 1965.36363636364 1788 0.000581482810602839 177 1.20795000245849 -1.25933857660271 -1 7.57883901549999 4108 177 1519 757 1789 3560 3234 508 1788 1723 2456 1594 M12711 GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized during embryonic development. 31/43 Gene Ontology BP GO:0048596 0.00468987428227932 0.012003292098705 2225 1938.90909090909 1789 0.000427263810314048 719 1.42691774909286 -1.48483959527139 -1 9.35957929174215 2222 980 1340 1789 719 2493 1670 3958 1087 1994 3076 1595 M15127 GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that activates or increases the frequency, rate or extent of DNA recombination. 16/22 Gene Ontology BP GO:0045911 0.0146595211712883 0.0277731074959301 1250 1916.90909090909 1789 0.00134164770786226 298 0.826051779896699 0.790647783379391 1 4.38489592950263 1247 1789 3349 1926 4158 1316 298 2077 904 3004 1018 1596 M11399 GO_MULTICELLULAR_ORGANISMAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MOVEMENT.html Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. 44/75 Gene Ontology BP GO:0050879 0.100209552333674 0.133987082473732 1115 1935.72727272727 1790 0.00955347091669725 201 0.883344026549918 0.773775981879576 1 2.6257003957715 1114 201 3248 794 1790 1910 984 3521 1443 3485 2803 1597 M11691 GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. 18/19 Gene Ontology BP GO:2000104 0.00411691282984841 0.0110155235177025 1080 2082.27272727273 1790 0.000374967013806546 305 0.714894926821466 0.714894926821466 1 4.77504506933588 1077 3528 3639 3331 674 859 305 1042 2175 4485 1790 1598 M13475 GO_RESPONSE_TO_ESTROGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTROGEN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 256/351 Gene Ontology BP GO:0043627 5.5382202911747e-09 1.86734340687216e-07 1430 1525.36363636364 1790 5.03474573192407e-10 102 1.26304644942096 1.25979960252856 1 29.0461381749905 1428 663 102 1790 2580 1541 2268 2124 2106 118 2059 1599 M10577 GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. 17/18 Gene Ontology BP GO:0008535 0.0247562898751029 0.0423185219650455 1575 2590.54545454545 1791 0.00227630347532088 775 0.64933163272531 -0.64933163272531 -1 3.03848171876027 1574 4199 3720 3581 1195 775 1687 1791 3887 4450 1637 1600 M12703 GO_CELLULAR_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. 71/154 Gene Ontology BP GO:0034754 0.000719917497291699 0.00315124752107081 1795 1694.09090909091 1791 6.54684716036712e-05 344 1.50709767492658 -1.46842243068022 -1 12.8788755013631 1791 3020 784 2484 344 1046 2421 2024 2818 967 936 1601 M12913 GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 37/48 Gene Ontology BP GO:0070169 0.00580469053631457 0.0134978636009354 1795 1996 1791 0.000529096636512626 610 1.58025764822653 1.57709495305507 1 10.091174515457 1117 2690 710 1791 4130 4470 2929 1795 897 610 817 1602 M14312 GO_ARGININE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARGININE_METABOLIC_PROCESS.html The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. 14/21 Gene Ontology BP GO:0006525 0.000336182116823418 0.00185338316300873 2795 2086.18181818182 1791 3.05666818021321e-05 77 1.4501474276248 -1.80325772668438 -1 13.5347049478587 2792 1791 1055 1749 2863 3968 4328 77 2748 1148 429 1603 M15233 GO_MUSCULOSKELETAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCULOSKELETAL_MOVEMENT.html The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. 44/75 Gene Ontology BP GO:0050881 0.100209552333674 0.133987082473732 1115 1912.63636363636 1791 0.00955347091669725 202 0.883344026549918 0.773775981879576 1 2.6257003957715 1115 202 3249 795 1791 1911 985 3256 1444 3487 2804 1604 M10174 GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST.html Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. 8/28 Gene Ontology BP GO:0044144 1.70707584979773e-05 0.000196609503195764 1310 1963.54545454545 1792 1.70708896342532e-06 49 1.5173527937136 1.66077693032416 1 19.2171881180035 1306 2910 4230 1792 49 2121 1567 3294 1105 1305 1920 1605 M14655 GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. 15/19 Gene Ontology BP GO:0006646 0.00347032246756039 0.00976264234677055 4360 2111.09090909091 1792 0.000315982612804907 53 1.55146849201628 -1.68061267398643 -1 10.6534542190603 4359 1792 1553 89 627 3961 2625 2940 53 851 4372 1606 M16762 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of macrophage differentiation. 13/17 Gene Ontology BP GO:0045651 0.00608563528960191 0.0139765355392486 2270 1626.18181818182 1793 0.000554775894886277 328 1.63586122842124 1.40477418199553 1 10.3619757287213 2266 1814 1062 1793 784 2539 2387 2678 328 1506 731 1607 M11425 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE.html Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. 12/29 Gene Ontology BP GO:0042749 0.00271203434479938 0.00809954801434629 1630 1974.27272727273 1795 0.000246853033376636 314 1.37673518432437 1.7100876443876 1 9.83418129890428 1627 3912 1795 3016 2162 690 621 314 3550 2576 1454 1608 M10173 GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 16/20 Gene Ontology BP GO:0061000 0.125817551372445 0.16296190716785 2380 2076.81818181818 1796 0.0121497856340175 882 1.01428294566495 -0.777534963697426 -1 2.72164934872119 2377 1142 2887 882 4397 1879 1093 1788 1612 2992 1796 1609 M10807 GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 20/27 Gene Ontology BP GO:0009065 0.0203969853918899 0.0360937425729452 1500 1901.81818181818 1796 0.00187168952063583 359 1.12894324493444 -1.42943585769222 -1 5.55735801878784 1500 1726 1841 2030 3419 750 1796 1215 3935 2349 359 1610 M10092 GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. 11/22 Gene Ontology BP GO:0050855 0.00306588169788651 0.00889373288046503 2880 1828.81818181818 1797 0.000279105691973175 21 1.14443586482089 1.22825045351034 1 8.0140913444683 2878 509 1713 360 595 2981 3473 2379 21 1797 3411 1611 M16126 GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. 71/105 Gene Ontology BP GO:2000177 0.00727378380605141 0.0161319904907327 1120 2088.18181818182 1797 0.000663449525034097 547 1.10051944020017 1.1677323255701 1 6.73312292077857 1116 3016 2416 3831 3650 1330 1139 547 1619 2509 1797 1612 M10223 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein. 11/14 Gene Ontology BP GO:0042511 0.00213247425624346 0.0068054888301103 3580 1782.81818181818 1798 0.000194049462429452 524 1.21564616538931 -1.10634520717829 -1 8.99647294192941 3576 524 1921 903 530 1188 1832 3182 750 1798 3407 1613 M14390 GO_CELL_FATE_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_DETERMINATION.html A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. 33/63 Gene Ontology BP GO:0001709 0.0720325179881174 0.101535082156531 1800 2104.72727272727 1798 0.00677319307236323 1057 1.46490851207832 1.33972719659297 1 4.96464588770238 1798 4423 1279 3562 2147 1468 1179 1446 1957 1057 2836 1614 M16924 GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. 288/418 Gene Ontology BP GO:0043062 2.80201534105854e-21 3.25944434548634e-18 95 1690.81818181818 1798 2.54728667368958e-22 4 1.46550432771631 1.50956296953666 1 87.6069198499569 92 3630 4 2973 1335 2115 1819 1265 3531 37 1798 1615 M13384 GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. 75/93 Gene Ontology BP GO:0046823 0.0158281317605504 0.0295420365350344 1110 2199.36363636364 1799 0.00144937902845297 695 1.07026533362435 1.32110538020383 1 5.5862723622437 1107 3336 3334 4195 1048 1799 2151 967 1623 3938 695 1616 M16115 GO_MITOCHONDRION_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_DISTRIBUTION.html Any process that establishes the spatial arrangement of mitochondria between and within cells. 14/17 Gene Ontology BP GO:0048311 0.0353508254431533 0.0563120132786691 1220 2451 1799 0.00326654351126425 525 1.29280881946728 1.29280881946728 1 5.51173723445214 1218 4571 3346 4086 1799 974 525 1298 4491 3853 800 1617 M10721 GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase C activity. 47/64 Gene Ontology BP GO:1900274 1.30248048885066e-07 2.95631303152298e-06 3070 1948.27272727273 1801 1.18407324178388e-08 154 1.43589844840553 1.41438531041027 1 27.1338679229628 3069 178 154 555 1801 1812 1724 4463 2647 440 4588 1618 M11975 GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. 386/495 Gene Ontology BP GO:0043623 0.00768661277458135 0.0167914597371488 475 1978.18181818182 1801 0.000701236477428172 128 0.947892527310447 -0.929315538647754 -1 5.74146115341388 475 2474 3972 2346 3931 128 453 1394 1801 4189 597 1619 M10813 GO_COENZYME_A_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 17/17 Gene Ontology BP GO:0015936 0.0546014222650218 0.0803734317618305 1650 1974.27272727273 1802 0.00509141865877307 455 0.754555533243884 -0.712291599843621 -1 2.81391230875069 1646 455 3272 1802 3942 1945 2122 1322 671 3533 1007 1620 M11337 GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY.html The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. 14/34 Gene Ontology BP GO:0007214 0.0404467889284287 0.0626987542743596 2640 1918.54545454545 1802 0.00374637457931545 571 1.28397948889638 -1.18354066917392 -1 5.26920022390096 2639 1167 1802 1775 1454 1918 571 2386 825 2787 3780 1621 M13677 GO_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. 610/798 Gene Ontology BP GO:0035295 7.6837796970593e-09 2.46569840899427e-07 1135 1691.09090909091 1802 7.6837797236275e-10 50 1.30806565575315 1.32245039785663 1 29.5419539366286 1132 1902 4442 1184 2715 545 1802 2137 2011 50 682 1622 M14345 GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. 26/42 Gene Ontology BP GO:0055083 0.00337230157832594 0.00956787758777475 2630 1851.63636363636 1802 0.000307043816346705 325 1.43457298283427 -1.06275542775077 -1 9.89289059204848 2630 325 633 753 1802 4074 2735 3078 896 844 2598 1623 M14604 GO_FUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. 11/15 Gene Ontology BP GO:0006004 2.70666219676322e-05 0.000281747185716762 2935 1695.18181818182 1803 2.46063227038985e-06 66 1.17021462632035 1.46758589137345 1 14.1931019672404 2933 512 2264 284 66 4042 3779 241 147 1803 2576 1624 M14392 GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoblast differentiation. 136/162 Gene Ontology BP GO:0045667 0.000359489724491492 0.00193153081761999 1955 1936.81818181818 1806 3.26862254675677e-05 426 1.40100661578783 1.44141968828205 1 12.9897812773135 1951 3310 426 2953 2597 1425 1774 4065 1806 438 560 1625 M11093 GO_OOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOGENESIS.html The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. 63/107 Gene Ontology BP GO:0048477 0.0306653489285334 0.0500125722272927 1690 1886.63636363636 1807 0.00282739260898941 488 1.27841837826533 1.01631167548369 1 5.67546069078906 1686 2123 1807 3232 3086 608 488 1343 831 2660 2889 1626 M10968 GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 84/99 Gene Ontology BP GO:0061180 6.58996621026825e-06 8.99211518368861e-05 4535 1898.36363636364 1808 5.99089631835823e-07 63 1.31117538740946 -1.34780970337827 -1 18.1275257695581 4535 63 250 224 2467 3458 4247 2139 1808 166 1525 1627 M14676 GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. 11/23 Gene Ontology BP GO:1902259 0.00500252082600612 0.0126092792001119 1810 2048.09090909091 1808 0.000455812024323705 734 1.20207725525805 1.24255021034402 1 7.79519428057308 1808 3244 2268 2142 734 3112 1639 1673 1580 1804 2525 1628 M12652 GO_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT.html The directed movement of calcium ions into a cell or organelle. 61/111 Gene Ontology BP GO:0070509 0.0297573134237742 0.0489087881882097 1660 1902.18181818182 1810 0.00274250937944998 134 0.966924038843312 1.02364062179099 1 4.32204383719883 1660 134 1632 1810 1590 2630 2288 1017 4255 1974 1934 1629 M13086 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. 220/306 Gene Ontology BP GO:1904950 0.033621907232618 0.0539664342776595 785 1719.54545454545 1811 0.00310427365384912 433 1.11618398155203 1.20424872161655 1 4.82777412472451 783 1969 2516 3499 1811 433 1057 1244 2261 2536 806 1630 M13724 GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of heart contraction. 39/57 Gene Ontology BP GO:0045823 0.00200902959695131 0.00653707322700311 1170 1862.72727272727 1811 0.000182806052931402 572 1.51840262575736 1.44285513180848 1 11.3304221822548 1169 3755 572 3759 1122 1944 1811 1399 2293 705 1961 1631 M16676 GO_STABILIZATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_STABILIZATION_OF_MEMBRANE_POTENTIAL.html The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 7/16 Gene Ontology BP GO:0030322 0.0280918435438717 0.0469003760350323 1385 2159.45454545455 1812 0.00284534114474159 1035 1.3755421177093 1.24764036487979 1 6.23867025938605 1384 2423 4643 3687 1677 1834 1789 1035 1362 1812 2108 1632 M11217 GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. 55/75 Gene Ontology BP GO:0070228 0.0146068833521104 0.0276959365270456 3390 2317.63636363636 1815 0.00133679789175655 853 1.24237449074422 -1.35496475156466 -1 6.6053510938955 3388 867 853 1299 4328 3097 1764 2871 1815 1066 4146 1633 M16445 GO_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cell proliferation. 1488/2183 Gene Ontology BP GO:0042127 2.2405297591863e-10 1.17136909769594e-08 1455 2036.54545454545 1815 2.24052975941219e-11 31 1.21243526606354 1.23636871461201 1 32.8666033031511 1455 1264 4624 2243 3571 1484 1637 1815 2296 31 1982 1634 M14612 GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. 81/143 Gene Ontology BP GO:0002688 7.87329946077208e-07 1.40971618572432e-05 1370 1759.36363636364 1816 7.15754752586203e-08 200 1.47398581325452 1.60204381886992 1 24.4351908040712 1366 2097 200 1982 4148 934 1901 2667 1816 479 1763 1635 M15649 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING.html The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. 25/29 Gene Ontology BP GO:0000717 0.00022196121461043 0.00136611842801896 1560 2460.36363636364 1816 2.01803283423016e-05 197 0.593606591436536 -0.610076828398172 -1 5.80289144702031 1560 3474 3883 3626 197 525 1332 1816 4234 4611 1806 1636 M16223 GO_ADAPTATION_OF_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTATION_OF_SIGNALING_PATHWAY.html The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. 18/26 Gene Ontology BP GO:0023058 0.00312518465961786 0.00903197777714403 3965 2526.09090909091 1816 0.000284512086706258 357 1.46183475527992 1.43952933635689 1 10.2062039189006 3963 1744 1816 1577 600 3428 4025 4130 357 1605 4542 1637 M15292 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that modulates the frequency, rate or extent of protein localization to nucleus. 274/363 Gene Ontology BP GO:1900180 0.0428338390638636 0.0658056330965693 1085 2384.45454545455 1819 0.00397193416583521 1082 1.03554486831876 1.13445175747012 1 4.17324544234776 1082 2493 3447 4088 4115 1595 1489 1193 1819 3636 1272 1638 M11253 GO_PHOTOTRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION.html The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. 31/64 Gene Ontology BP GO:0007602 0.0131845049046742 0.0256024906121379 1500 2374.18181818182 1820 0.00120583531232255 994 1.46842029203972 1.46954697627073 1 7.98047953925558 3665 2708 1500 1478 994 3278 3431 1820 1498 1565 4179 1639 M13303 GO_TRANSEPITHELIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSEPITHELIAL_TRANSPORT.html The directed movement of a substance from one side of an epithelium to the other. 10/18 Gene Ontology BP GO:0070633 0.000973673063054123 0.00389888189534495 1815 1997.09090909091 1821 8.85549324704042e-05 395 1.10916033109349 -1.27444622445078 -1 9.12487988023148 1811 3250 1821 2010 395 925 1681 4314 2012 2317 1432 1640 M10744 GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 18/29 Gene Ontology BP GO:0072207 0.00463602901113589 0.0119113434504778 1825 2011.63636363636 1822 0.000422347942645459 561 1.67759361948995 1.42937566158888 1 11.0248650982263 1822 3179 1560 2856 716 1354 561 3831 976 2128 3145 1641 M14037 GO_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 920/1440 Gene Ontology BP GO:0033993 5.61791752759623e-13 6.37565128192811e-11 1235 2023.90909090909 1823 5.61791752759763e-14 15 1.24125889815333 1.26639458342268 1 43.2568843256196 1231 1295 4469 2247 3334 1327 1943 1823 2817 15 1762 1642 M10035 GO_LACTATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSPORT.html The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 12/13 Gene Ontology BP GO:0015727 0.0341964070038803 0.05469779367104 4500 2308.45454545455 1824 0.00315816477481705 603 1.47822912478907 -1.77805546305787 -1 6.36762219488946 4498 1824 1006 1451 3017 3300 1779 3592 603 889 3434 1643 M13785 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK.html The synchronization of a circadian rhythm to environmental time cues such as light. 44/73 Gene Ontology BP GO:0009649 0.0338216852925428 0.0542289116699523 1535 1753.09090909091 1824 0.00312301059001546 215 0.949911299591975 1.01474289650534 1 4.10017149293375 1534 215 2984 1837 1824 1709 943 2438 2104 3185 511 1644 M14953 GO_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 32/46 Gene Ontology BP GO:0010226 0.017934830016013 0.0326045591875377 770 2080 1824 0.00164388445604958 352 1.22658278741045 1.11299305784302 1 6.22408596742758 768 3451 2137 3639 4038 1135 352 1824 3609 1315 612 1645 M15718 GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of smoothened signaling. 27/42 Gene Ontology BP GO:0045880 0.000156790805464489 0.00104370188530224 3925 2207.54545454545 1824 1.42547255302339e-05 173 1.39341003403492 -1.31076797697974 -1 14.1928258124628 3922 1665 1824 1526 173 4272 3918 2546 1609 2077 751 1646 M16730 GO_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. 376/476 Gene Ontology BP GO:0048589 0.00141022618953117 0.00509455159929233 1860 1612 1824 0.000128284633943521 536 1.21173220731906 1.26304028458057 1 9.48845023566035 1857 1355 536 1858 3118 1313 1824 1891 1967 672 1341 1647 M13665 GO_LACTATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 12/13 Gene Ontology BP GO:0035873 0.0341964070038803 0.05469779367104 4500 2304 1825 0.00315816477481705 604 1.47822912478907 -1.77805546305787 -1 6.36762219488946 4499 1825 1007 1452 3018 3301 1780 3533 604 890 3435 1648 M16570 GO_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_GROWTH.html The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. 172/205 Gene Ontology BP GO:0016049 0.0835521580359696 0.114986155380469 1025 1990.09090909091 1826 0.00790045544194474 938 1.15709022364588 1.24206754613325 1 3.70545218909745 1023 3297 1218 3289 2724 1275 938 1826 3000 1412 1889 1649 M16132 GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. 13/22 Gene Ontology BP GO:0002523 0.00119754876698255 0.00450096479222116 1265 1973.18181818182 1827 0.000108927376209716 524 1.88660295591165 1.76754448601609 1 15.1259765463486 1264 1827 524 981 1689 2020 2466 4101 3835 1024 1974 1650 M16707 GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 11/13 Gene Ontology BP GO:0051533 0.00821684056452652 0.0177168485388053 1270 1923.27272727273 1827 0.000749790118633809 350 0.959312263026046 1.12904939210883 1 5.73434613425577 1266 2378 3189 920 857 3613 1887 1762 1827 3107 350 1651 M11245 GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 40/69 Gene Ontology BP GO:0051349 0.0203364758964066 0.0360204120083669 2905 2260.18181818182 1828 0.00186608478781731 943 1.29643940570286 1.17245554976363 1 6.38737479208251 2902 2183 943 987 1132 4085 3386 1614 1828 1541 4261 1652 M15333 GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. 13/14 Gene Ontology BP GO:0006047 1.86501409128455e-05 0.000211141376319878 3380 1976.63636363636 1828 1.69548172893158e-06 48 1.12599618337585 -1.05929549501279 -1 14.1387070105633 3376 1204 2691 1507 48 1828 2323 4416 285 1504 2561 1653 M11945 GO_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_FORMATION.html The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 24/26 Gene Ontology BP GO:0003272 0.00776883922401362 0.0169075813420652 1940 1960.36363636364 1829 0.000708764513830006 754 1.59751274356411 1.53026623516819 1 9.667223088589 1940 3135 754 3920 952 2082 1682 2495 1829 1778 997 1654 M11236 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. 15/18 Gene Ontology BP GO:0045955 0.00707008439494899 0.0157553173801234 1155 1899.90909090909 1830 0.00064480982726085 184 1.0534947139288 0.838036633844977 1 6.48192163088622 1153 3206 3090 2223 3280 827 184 1674 528 2904 1830 1655 M12052 GO_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. 78/117 Gene Ontology BP GO:0030183 0.074055047722792 0.103726109889871 1515 1887.72727272727 1830 0.0069701850506995 94 1.1204903030964 1.15945721374302 1 3.75936900620683 1515 94 1830 629 1607 2561 2093 4325 586 2296 3229 1656 M13067 GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 29/33 Gene Ontology BP GO:0010869 0.0122241394435608 0.024080830157023 1295 1760.45454545455 1830 0.00111750864493081 422 1.21389183006646 1.58665981312264 1 6.70577665391901 1293 2230 2174 2665 1319 2831 1830 709 422 3051 841 1657 M13446 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. 194/275 Gene Ontology BP GO:2000377 5.05078692978423e-05 0.000458115235561131 3110 2118.45454545455 1832 4.59172990008724e-06 214 1.23200268285844 -1.13055129449938 -1 14.0538203658422 3110 1396 312 1633 1819 3971 3350 1832 2467 214 3199 1658 M14203 GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epidermal cell differentiation. 54/67 Gene Ontology BP GO:0045604 0.0204471522155671 0.0361162605198555 2140 1873.54545454545 1832 0.00187633649514237 386 1.47569051816228 1.1866007116789 1 7.26617131593167 2137 2638 1497 2073 3743 556 386 2829 1389 1529 1832 1659 M16827 GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 14/22 Gene Ontology BP GO:0071371 0.0762184711329701 0.106212802090958 3315 2053.63636363636 1832 0.00718133337111429 212 1.54775460319621 0.934632824564206 1 5.14250890762987 3312 1810 2182 1363 1622 1832 1902 1654 212 2226 4475 1660 M14249 GO_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOR_SIGNALING.html Any process that modulates the frequency, rate or extent of TOR signaling. 83/108 Gene Ontology BP GO:0032006 0.0569448881844702 0.0833644837474259 755 2082.45454545455 1833 0.00531587093803899 752 1.01440104117523 1.00344308351372 1 3.73157323536446 1848 1496 3524 2441 3750 1816 755 1833 891 3801 752 1661 M10370 GO_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_BINDING.html Any process that modulates the frequency, rate or extent of protein binding. 231/277 Gene Ontology BP GO:0043393 0.010488436350896 0.02143289167357 1170 2098 1835 0.000958070543610479 919 1.04848214943569 1.14865034463853 1 5.97192087464234 1168 2507 3092 3388 919 1737 1723 1835 3075 2663 971 1662 M12244 GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE.html Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. 12/12 Gene Ontology BP GO:0048875 0.00604505804554582 0.0138970627894885 1915 1778.90909090909 1835 0.000551066595971433 494 1.75791021029654 1.13187092061059 1 11.1507459912102 1915 1835 880 1768 3399 2007 538 494 3786 577 2369 1663 M13312 GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 165/217 Gene Ontology BP GO:0010771 0.00110317863344328 0.00423872021586424 1715 1623.09090909091 1835 0.00010033929139349 513 1.30993326308041 1.38660378773481 1 10.6159868587739 1711 2531 513 1868 2568 1835 1983 2073 1489 592 691 1664 M11933 GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. 12/17 Gene Ontology BP GO:0003161 0.0019600202263897 0.00642251698126148 760 1634.54545454545 1836 0.000178342602308154 72 1.27126974782825 1.08387755692849 1 9.51793670763187 758 1836 2024 2182 2592 651 72 3782 1579 1955 549 1665 M10374 GO_REGULATION_OF_ICOSANOID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ICOSANOID_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. 20/42 Gene Ontology BP GO:0032303 0.00963280699354493 0.0200453716193938 1535 2095.36363636364 1837 0.000879567734594232 626 1.28793572327908 1.297466422296 1 7.46622194992041 1532 3512 1835 3076 1884 1526 795 626 4297 1837 2129 1666 M16070 GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS.html The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. 49/57 Gene Ontology BP GO:0006921 0.00109912675848036 0.0042266961698888 1840 1974.45454545455 1837 9.99705699978693e-05 189 0.905369395244064 -0.911876432472763 -1 7.3378381807428 1837 189 3209 630 411 3144 4309 2551 1146 2822 1471 1667 M14064 GO_RETINA_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_LAYER_FORMATION.html The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. 30/38 Gene Ontology BP GO:0010842 0.000118397741323008 0.00085677245781642 2955 2038.90909090909 1838 1.07640103302493e-05 38 1.16472672792959 1.04337170847698 1 12.2030944013762 2954 987 1838 1724 1617 2880 2202 38 1678 2302 4208 1668 M14347 GO_REGULATION_OF_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. 77/107 Gene Ontology BP GO:0006885 0.00946370769245249 0.019862260664403 1375 2085 1839 0.000864060404951963 615 1.17764247658943 1.48688086276981 1 6.8419804204492 1373 3334 1839 3703 3324 896 1563 615 2749 2519 1020 1669 M13587 GO_GOLGI_TO_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_ENDOSOME_TRANSPORT.html The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. 26/27 Gene Ontology BP GO:0006895 0.0313483528220422 0.0508590954257191 1845 2223.18181818182 1841 0.00289128751434395 607 0.801219336850199 -0.865363964049334 -1 3.53301628003048 1841 2749 3813 2104 4271 898 1325 1047 1642 4158 607 1670 M10714 GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. 37/77 Gene Ontology BP GO:0002286 0.0595647578823223 0.086367970840276 3270 2105.63636363636 1842 0.00556739767365354 311 1.3571861254426 -1.44081635358607 -1 4.92481802597082 3268 1601 1132 744 1842 2510 2103 4179 311 1039 4433 1671 M12015 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. 34/44 Gene Ontology BP GO:0002832 0.0132108252699778 0.0256231638104239 2770 1853 1842 0.00120825714719791 833 1.18490847249119 1.25337469920734 1 6.4361883249602 1937 1636 2766 1842 996 2618 1440 833 2766 2616 933 1672 M12656 GO_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 668/1075 Gene Ontology BP GO:0051046 8.03235969825504e-09 2.55990203260142e-07 1090 2010.90909090909 1842 8.0323597272885e-10 51 1.21741445781924 1.25817613525984 1 27.4261308492098 1088 2446 4381 1460 3328 1347 1842 1473 2330 51 2374 1673 M14429 GO_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. 132/179 Gene Ontology BP GO:0006006 0.000352236806435562 0.00189914004674933 3485 1816.36363636364 1842 3.20266558985008e-05 72 1.01068473482334 -0.890391063967108 -1 9.39322350897118 3484 740 1842 72 251 598 2593 4594 836 1850 3120 1674 M16102 GO_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that modulates the frequency, rate or extent of muscle adaptation. 75/102 Gene Ontology BP GO:0043502 0.00538459829077023 0.0132985859060265 3485 2047.27272727273 1842 0.000490711152006593 366 1.15754481079115 1.23743393166531 1 7.41453624357948 3482 828 1315 366 749 3203 3209 2542 1842 633 4351 1675 M13126 GO_NEURON_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. 11/44 Gene Ontology BP GO:0048665 0.0501163480914107 0.0747647860433902 3285 2221.72727272727 1843 0.00466325434152309 664 1.37401065378779 1.24443720998439 1 5.2803367744901 3285 1228 1480 1152 2799 1843 664 2981 3822 1802 3383 1676 M14822 GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY.html The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 24/26 Gene Ontology BP GO:0035058 0.0048225893416294 0.01227645491747 2435 2093.09090909091 1843 0.000439381220902464 725 0.835355683966984 -0.68874545467635 -1 5.4470158006523 2432 1692 3483 2596 725 1308 3180 765 1843 3859 1141 1677 M11475 GO_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 604/850 Gene Ontology BP GO:0031175 0.00316392058879774 0.00911427846241778 975 1830.18181818182 1844 0.000316843431317161 435 1.24112022688992 1.29533324752522 1 8.64689815268233 973 1904 4306 1233 2857 1844 1218 1631 1853 435 1878 1678 M14135 GO_DETECTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS.html The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. 51/106 Gene Ontology BP GO:0009583 0.0609949136346753 0.0881669254868419 2465 1942.09090909091 1845 0.00570497203369785 887 1.32292698868486 1.34021704915278 1 4.75973833293158 2462 887 1138 960 1684 2611 3040 1976 1845 1661 3099 1679 M16290 GO_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of dendrite development. 162/194 Gene Ontology BP GO:0050773 0.142276936297971 0.180779515181447 2335 1921.72727272727 1845 0.0138553013232708 841 1.07012246154463 1.14553998043562 1 2.70719976687169 1506 1415 2054 841 1905 1462 1845 3884 2335 2331 1561 1680 M12390 GO_REGULATION_OF_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEEDING_BEHAVIOR.html Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. 14/30 Gene Ontology BP GO:0060259 0.00015673822672086 0.00104370188530224 1740 1775.36363636364 1846 1.42499449631507e-05 172 1.24694311670463 1.36220911448012 1 12.6998401640856 1736 2849 2077 3316 172 1402 302 645 2966 2218 1846 1681 M13558 GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 1384/2007 Gene Ontology BP GO:1901700 8.64682045138045e-13 8.74644686092896e-11 1185 1958.54545454545 1846 8.64682045138381e-14 17 1.18767306213746 1.20117596718899 1 40.8314521898057 1183 1268 4435 2241 2506 1555 1846 1750 2657 17 2086 1682 M15459 GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. 12/18 Gene Ontology BP GO:0014741 8.91030550377701e-05 0.000685283496017759 2770 1610.81818181818 1846 8.1006058218065e-06 131 1.29005664413897 1.33233111106322 1 13.9451610675676 2770 1846 2344 1869 131 1126 868 3224 494 894 2153 1683 M12988 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 61/84 Gene Ontology BP GO:0046364 0.000661495095702641 0.00297672793066188 2385 1830.63636363636 1847 6.01540070493492e-05 332 0.926319831794511 -0.979549488141732 -1 7.99010332483769 2385 859 3217 2285 332 784 2273 1709 1327 3119 1847 1684 M15417 GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. 153/211 Gene Ontology BP GO:1990267 0.0164711005649498 0.0304852947210467 1270 2197.90909090909 1847 0.00150870233619722 878 1.23382854651164 1.34732951189298 1 6.38404256398703 1268 3302 878 3692 3082 1614 1728 3464 1847 1440 1862 1685 M15680 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 103/201 Gene Ontology BP GO:0070588 0.0166661044907624 0.0307605649327718 1570 1871.81818181818 1847 0.00152670127793006 48 1.09204676575982 1.0552094983933 1 5.63463796828654 1567 48 882 2267 2966 1744 2038 1847 3664 1973 1594 1686 M16870 GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. 206/365 Gene Ontology BP GO:0010466 2.24511349472495e-07 4.80203408091115e-06 795 1819.18181818182 1847 2.04101247621836e-08 165 1.22220303994697 1.29837386151715 1 22.2137884318 795 1393 165 2501 665 1847 1942 3329 3925 1037 2412 1687 M11648 GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 10/13 Gene Ontology BP GO:0032352 3.74272918668808e-05 0.000354682666103047 3485 1994.36363636364 1848 3.40253896457349e-06 86 1.27701145964575 1.16883312615065 1 15.0528566854638 3481 1848 1952 1129 86 3651 2071 1008 658 1647 4407 1688 M13512 GO_POSITIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXON_EXTENSION.html Any process that activates or increases the frequency, rate or extent of axon extension. 49/54 Gene Ontology BP GO:0045773 0.10091612026627 0.134854310051394 740 2345 1848 0.0096242012914478 739 1.29580662747293 1.19538986437843 1 3.8442924678122 739 4047 1792 3745 3111 858 997 4475 2930 1253 1848 1689 M16880 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin depolymerization. 17/21 Gene Ontology BP GO:0030836 0.105487829761035 0.139878846360243 1325 2181.27272727273 1848 0.0100830733637301 879 1.00011381402226 1.00158303019362 1 2.91029849135163 1324 3524 2570 3003 2394 879 1351 1848 3827 1487 1787 1690 M16127 GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 20/20 Gene Ontology BP GO:0009226 2.48175939739618e-05 0.000264385761594786 2170 1758.54545454545 1849 2.25617035807496e-06 61 0.962114493432393 -0.996155361596463 -1 11.7580947412664 2170 1073 2802 1461 61 1630 3242 2550 416 1849 2090 1691 M14748 GO_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY.html The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. 33/45 Gene Ontology BP GO:0014896 0.00961493493258401 0.0200443782909052 1005 2021.54545454545 1851 0.000877928655222213 221 1.05885337315493 1.28394610587377 1 6.1364025035653 1005 3425 1851 2919 3824 709 309 884 3792 3298 221 1692 M14660 GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 15/35 Gene Ontology BP GO:0032660 0.000751344112503078 0.00323704088470076 2570 1805.36363636364 1852 6.83273485761005e-05 354 1.17502448122922 1.06466584276157 1 9.99193566774097 2568 1153 1753 1126 354 3644 1911 1993 2240 1265 1852 1693 M11263 GO_IMMUNE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. 664/940 Gene Ontology BP GO:0002520 0.00749267612717601 0.0164683146054558 1500 2082.45454545455 1853 0.000751805975271223 520 1.14165282752302 1.15250304525192 1 6.95020313413614 1496 1315 4290 1228 3164 1853 1776 2313 2595 520 2357 1694 M10727 GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. 10/15 Gene Ontology BP GO:0045779 0.000515069451704753 0.00247074036987857 3925 2051.27272727273 1854 4.68354618710644e-05 302 1.86444437827705 -2.23054334321671 -1 16.6085971758608 3921 1854 1250 1551 302 3501 2995 2493 910 1075 2712 1695 M15753 GO_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. 425/611 Gene Ontology BP GO:0048732 4.95305413350903e-08 1.36370182740932e-06 1680 1930 1854 4.50277658638318e-09 114 1.28461484321759 1.23677311907668 1 25.7498287681795 1680 2468 125 1284 2790 2103 1615 4021 1854 114 3176 1696 M12626 GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that reduces the force with which blood travels through the systemic arterial circulatory system. 9/15 Gene Ontology BP GO:0003085 1.50075175864132e-05 0.000178593297518109 4320 2417.27272727273 1855 1.50076189388894e-06 42 1.71864950619839 -2.43936403022255 -1 22.0132735146521 4320 1855 4378 1239 42 4359 4152 3339 185 1466 1255 1697 M12799 GO_NEPHRON_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. 101/140 Gene Ontology BP GO:0072009 2.12488768615234e-07 4.59865228077527e-06 1855 1985.72727272727 1855 1.93171626489668e-08 163 1.35331922709838 1.24860599497346 1 24.6849571909031 1855 1465 163 487 4458 2215 1884 3729 1518 265 3804 1698 M10848 GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. 64/98 Gene Ontology BP GO:2000737 0.00971461549612534 0.0201460916447987 1720 2029.90909090909 1856 0.000887070885142101 630 1.2201025016391 1.28987251375794 1 7.06334809054346 1718 3707 1903 3779 2820 1447 1216 630 2396 1856 857 1699 M12728 GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. 34/51 Gene Ontology BP GO:1901224 0.00473179175492937 0.0120773598659826 130 2082.45454545455 1856 0.000431090882889036 75 0.944806283350581 1.00230301931399 1 6.18503370044124 127 4443 3290 4616 1856 75 245 874 2808 3895 678 1700 M13781 GO_CELLULAR_RESPONSE_TO_CHOLESTEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CHOLESTEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. 25/28 Gene Ontology BP GO:0071397 0.00429191903836814 0.0113146171589388 1860 1724 1856 0.000390937724035489 147 1.31578505290385 -1.17428508230046 -1 8.745232701453 1856 2251 1513 2096 688 540 2433 566 3666 3208 147 1701 M13278 GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. 16/23 Gene Ontology BP GO:0070233 0.0138299758499623 0.0265255060304512 1860 2015.36363636364 1857 0.00126524444420243 949 1.25841069768928 -1.42000691114223 -1 6.77142964564766 1802 1784 1940 1857 1005 3399 1860 4420 949 1896 1257 1702 M14592 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/80 Gene Ontology BP GO:0051926 0.00101971259545889 0.00403442596577099 1795 1684.36363636364 1857 9.27441404558344e-05 180 1.10973508769826 1.00508726659528 1 9.07330266760656 1793 1598 1556 1912 671 2216 2188 180 2633 1924 1857 1703 M11024 GO_HEME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_METABOLIC_PROCESS.html The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. 28/37 Gene Ontology BP GO:0042168 2.22186477648483e-05 0.00024325498364668 1860 1993.63636363636 1858 2.01989746933698e-06 56 0.79451771027313 -0.796678558940596 -1 9.80629061507326 1858 1660 3287 590 56 893 1488 2492 3232 3687 2687 1704 M14956 GO_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid oxidation. 34/43 Gene Ontology BP GO:0046320 6.8962201149495e-05 0.00056994870683588 3010 1979.45454545455 1859 6.26948754226424e-06 116 1.10335221638113 1.15835683014069 1 12.227308264776 3008 272 1859 177 116 3381 2972 2725 1482 1444 4338 1705 M16717 GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of anion transport. 64/109 Gene Ontology BP GO:1903793 0.00334266332961052 0.00951279050316683 2125 1721.72727272727 1859 0.000304341179698188 345 1.36949742896378 1.53006151545102 1 9.45538401838103 1030 2124 1116 2520 2123 1866 1254 345 3921 1859 781 1706 M12306 GO_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_ACTIVATION.html The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. 17/42 Gene Ontology BP GO:0045576 0.0048588213855161 0.0123406637045887 1050 2012 1860 0.0004426896052962 427 1.08037240189414 1.11926703063493 1 7.0394296454277 1048 1780 1834 3543 3228 1860 577 427 3687 2036 2112 1707 M12556 GO_MESENCHYMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. 148/195 Gene Ontology BP GO:0048762 1.98978845968959e-12 1.74688409489352e-10 1325 1676 1860 1.80889859971944e-13 36 1.44374516973254 1.56348260204702 1 48.1543878787256 1322 2017 36 2284 3175 3498 2277 1153 1860 80 734 1708 M11273 GO_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_PROCESS.html A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. 14/21 Gene Ontology BP GO:0003016 0.00865915988285101 0.0184398493981262 4010 2327.72727272727 1862 0.000790311925022452 873 0.975866653915573 -1.22698012594898 -1 5.77552809240108 4008 1165 1862 1480 873 3810 3113 1857 1334 2213 3890 1709 M16261 GO_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. 123/170 Gene Ontology BP GO:0030217 0.106009631452577 0.14045068768475 1855 2269.90909090909 1862 0.0101355831772634 1087 1.15388982647093 1.09325289398088 1 3.35243112611452 1852 2555 1278 2360 4579 1441 1087 1862 3300 1301 3354 1710 M10964 GO_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of dendrite morphogenesis. 103/125 Gene Ontology BP GO:0048814 0.0316105269203181 0.0512130159332312 1550 1886.09090909091 1863 0.00291582473809919 1292 1.05527853675565 1.17302321881225 1 4.64581782535932 1548 1462 2158 1863 1292 1475 1509 2554 2355 2659 1872 1711 M14679 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of production of a cytokine. 352/572 Gene Ontology BP GO:0001819 0.00379714918494099 0.010384592062893 825 2110.63636363636 1863 0.000345792623360227 645 1.18128762882953 1.26978312499874 1 8.00066473133444 823 3627 645 3354 3266 1689 1822 1863 2744 1135 2249 1712 M10254 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 94/124 Gene Ontology BP GO:1903845 0.000927025268446375 0.00375760657804843 480 1791.09090909091 1866 8.43105567661096e-05 73 1.13021515115544 1.12351655355372 1 9.36023435264415 480 3675 1866 4233 1971 131 809 169 3773 2522 73 1713 M12439 GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 45/63 Gene Ontology BP GO:0010464 0.00849819944363423 0.0181638866619536 4210 2379.90909090909 1867 0.000775564097450257 619 1.2620365401126 -1.28371375489029 -1 7.50056678532263 4206 905 768 1158 1808 4194 3324 4574 1867 619 2756 1714 M15113 GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. 94/124 Gene Ontology BP GO:0030512 0.0022767182859795 0.00713852438319583 485 1809.54545454545 1867 0.000207188892464869 74 1.13021515115544 1.12351655355372 1 8.28330787795934 481 3676 1867 4234 1972 132 810 362 3774 2523 74 1715 M12559 GO_ATRIAL_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_MORPHOGENESIS.html The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. 13/20 Gene Ontology BP GO:0060413 0.000153753027562595 0.00103984424018714 1380 1816.81818181818 1868 1.39785249150601e-05 165 1.27192798447782 1.39934095821456 1 12.9615125792062 1379 3227 2709 2214 165 1868 1280 2468 199 2697 1779 1716 M11293 GO_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 585/702 Gene Ontology BP GO:0030163 0.0801831045780205 0.11087428992616 3055 2348.09090909091 1871 0.00832323402536611 344 0.889504673317982 -0.861412385753775 -1 2.8941687108208 3055 596 4292 344 1682 1871 3493 3206 1263 4308 1719 1717 M13149 GO_HEPATOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a hepatocyte, the main structural component of the liver. 16/17 Gene Ontology BP GO:0097284 0.0236843496798228 0.0407104835833822 1825 1956.63636363636 1872 0.00217665787726965 628 1.05386669882109 1.08936318035689 1 4.99872519614981 1821 3200 2756 1872 1640 2407 3152 931 628 1894 1222 1718 M16525 GO_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GTPASE_ACTIVITY.html Any process that modulates the rate of GTP hydrolysis by a GTPase. 620/772 Gene Ontology BP GO:0043087 0.181904922241548 0.224212875017199 1695 2308 1872 0.0198774574491149 456 1.08227703410099 1.03923867884695 1 2.39205442396275 1695 1317 4630 456 3659 1584 2267 3518 1872 1163 3227 1719 M13498 GO_CELLULAR_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. 14/21 Gene Ontology BP GO:0006883 0.00310130927759209 0.00897412442079353 1060 2008.27272727273 1873 0.00028233543614857 351 1.33722807144105 1.68502118733482 1 9.34807815264457 1057 3565 1873 4160 597 2514 351 1251 3067 2792 864 1720 M10048 GO_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. 90/162 Gene Ontology BP GO:0021510 0.0200795885832342 0.0356740456959865 1365 1760.36363636364 1874 0.0018422939307835 357 1.22761187703781 1.23610812070099 1 6.0653176578092 1364 2082 1383 2804 2682 1114 1106 2288 2310 1874 357 1721 M11783 GO_AEROBIC_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AEROBIC_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. 59/63 Gene Ontology BP GO:0009060 0.000675488927447329 0.00301347073769168 1745 2222.36363636364 1874 6.14269471863171e-05 335 0.603049343798676 -0.574015876736446 -1 5.18698177757454 1741 1535 4090 1874 335 1408 2467 2730 1042 4357 2867 1722 M12956 GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of muscle cell differentiation. 178/264 Gene Ontology BP GO:0051147 0.140825042901382 0.179277407556807 1180 2028.90909090909 1878 0.0137036655479325 1180 1.18630003997663 1.1928461546992 1 3.01696100095727 1180 2000 1361 1878 4330 1951 2039 3075 1574 1560 1370 1723 M14374 GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY.html Any process that activates or increases the activity of a cyclase. 43/72 Gene Ontology BP GO:0031281 0.032250959350475 0.0520512361629415 4095 2407.36363636364 1879 0.0029757890676093 1005 1.20382398711927 -1.19939832466656 -1 5.27226430606381 4092 2167 1217 1005 1301 3639 4046 1879 1797 1775 3563 1724 M15039 GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 55/65 Gene Ontology BP GO:0009066 0.00807809944925442 0.0174597420256295 1880 1877.63636363636 1879 0.000737083137039719 645 1.20252894685874 -1.2485004647836 -1 7.21699341490928 1879 1561 3339 1098 853 2088 2497 1508 645 2539 2647 1725 M10210 GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 25/40 Gene Ontology BP GO:0045745 0.00550489032123665 0.0134540021460564 4425 2019.45454545455 1881 0.000501701202838115 752 1.63144216087431 1.30131972869178 1 10.4262572945462 4421 1690 1139 1366 752 2548 2251 928 2527 1881 2711 1726 M12364 GO_NEURAL_CREST_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_MIGRATION.html The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. 51/70 Gene Ontology BP GO:0001755 6.92207613993013e-05 0.000571071281544235 3335 2189.45454545455 1881 6.29299449600605e-06 328 1.3903762153489 -1.20574593078479 -1 15.4068091419372 3335 1563 328 1476 813 3558 4040 1881 3009 687 3394 1727 M13025 GO_CELL_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGGREGATION.html The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. 35/45 Gene Ontology BP GO:0098743 0.000651724129512719 0.0029508593895 1885 1756 1881 5.9265206839183e-05 388 1.39519443037658 1.4615180114509 1 12.0579265994978 388 2698 467 2721 1217 1885 2108 1414 3617 920 1881 1728 M11947 GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT.html The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. 135/243 Gene Ontology BP GO:0015850 2.27234731693998e-06 3.53619801529155e-05 3610 1848.18181818182 1882 2.06577242183378e-07 57 1.3072134332861 -1.37943687508491 -1 19.8842357877892 3608 747 225 57 2118 2408 4282 2876 1882 363 1764 1729 M16745 GO_CARTILAGE_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_CONDENSATION.html The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. 35/45 Gene Ontology BP GO:0001502 0.000651724129512719 0.0029508593895 390 1756.63636363636 1882 5.9265206839183e-05 389 1.39519443037658 1.4615180114509 1 12.0579265994978 389 2699 468 2722 1218 1886 2109 1411 3618 921 1882 1730 M13261 GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of B cell mediated immunity. 33/54 Gene Ontology BP GO:0002712 0.0809224537480398 0.111763780733045 1785 2053.72727272727 1883 0.00764199389366858 921 1.08266733044532 1.09669728474106 1 3.51212944149517 1781 966 2387 1883 4255 2078 1827 1749 2582 2162 921 1731 M10812 GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 187/272 Gene Ontology BP GO:0071216 0.0346720861364573 0.0553824980408293 600 2130.90909090909 1884 0.00320280805537178 598 1.10202683359985 1.11465623181092 1 4.72402271290499 598 3294 1011 2964 3795 1333 1292 1884 3973 1382 1914 1732 M10317 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 41/52 Gene Ontology BP GO:0050732 0.0284563412518075 0.0474068585193915 2575 2013.09090909091 1885 0.00262102017195898 232 1.1252235157691 -1.00114984725231 -1 5.0834821776834 2572 3385 2868 877 1242 2725 3127 1608 232 1623 1885 1733 M16206 GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels. 880/1179 Gene Ontology BP GO:0072358 3.07365458397857e-09 1.13505672851209e-07 1105 1894.54545454545 1885 3.07365458822988e-10 44 1.25323810968328 1.29587174025366 1 29.7468865295387 1104 1885 4603 2736 2485 1653 1918 1133 2530 44 749 1734 M12754 GO_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. 39/50 Gene Ontology BP GO:0009112 0.017693196316498 0.0322343157637687 1890 2126.63636363636 1886 0.00162155585954568 379 1.19871802728841 -1.06529782870777 -1 6.10277607786591 1886 4072 3333 3085 1080 1059 2416 1199 379 3265 1619 1735 M16442 GO_CIRCULATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. 880/1179 Gene Ontology BP GO:0072359 3.07365458397857e-09 1.13505672851209e-07 1105 1915.36363636364 1886 3.07365458822988e-10 45 1.25323810968328 1.29587174025366 1 29.7468865295387 1105 1886 4623 2737 2486 1654 1919 1333 2531 45 750 1736 M10692 GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER.html The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 15/16 Gene Ontology BP GO:0090557 0.155871873491617 0.196227770086869 1140 2160.81818181818 1887 0.0152865907328652 472 0.696620193126564 0.808273277978442 1 1.67377516117792 1140 472 2926 1316 3129 1887 1250 2165 3763 3871 1850 1737 M13900 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that activates, maintains or increases the rate of developmental growth. 195/260 Gene Ontology BP GO:0048639 0.00577426225782821 0.0134540021460564 700 1943.54545454545 1888 0.000526315789473684 197 1.25526040506981 1.25379183390859 1 8.019687820819 1888 699 805 197 4530 2061 2457 3984 1183 696 2879 1738 M15511 GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT.html Any process that modulates the frequency, rate or extent of the movement of a cellular component. 865/1139 Gene Ontology BP GO:0051270 5.17095340332093e-12 3.88071712671811e-10 470 1915.27272727273 1888 5.17095340333297e-13 21 1.22698205315614 1.30645425454469 1 39.4687298612689 466 1888 4560 2260 3292 1928 1654 717 2782 21 1500 1739 M11045 GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. 14/21 Gene Ontology BP GO:0003323 0.000464273604451013 0.00231788098874524 1890 1484 1889 4.22156009701277e-05 84 1.10219626512135 1.1077551306568 1 9.9185988158591 1889 465 1920 384 283 2521 1214 2959 84 2211 2394 1740 M11622 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 78/85 Gene Ontology BP GO:0007173 0.00577426225782821 0.0134540021460564 1870 1755.09090909091 1889 0.000526315789473684 88 1.12453395002459 1.12757768150872 1 7.18338385002277 1870 88 1889 178 3496 1969 2783 2185 635 595 3618 1741 M11450 GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 814/1070 Gene Ontology BP GO:0051960 7.90366263956396e-06 0.000105073549319689 1390 1909.72727272727 1890 7.90369075025208e-07 145 1.22054139717317 1.27167302986973 1 16.5915132612972 1387 1890 4301 1185 3019 1292 2116 2804 2043 145 825 1742 M11356 GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 16/23 Gene Ontology BP GO:0060390 8.63942661251108e-06 0.000114202420534131 2610 1619.09090909091 1891 7.85405503620948e-07 25 1.27721912083211 1.25648762246511 1 17.2044637719245 2607 1155 2135 1389 25 2668 2944 1996 206 1891 794 1743 M11150 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. 94/110 Gene Ontology BP GO:0048010 0.00577426225782821 0.0134540021460564 2485 1763.54545454545 1892 0.000526315789473684 64 1.14637658620805 -1.06753231793367 -1 7.32311901966817 2484 64 1892 232 2280 2204 1438 2334 1341 1535 3595 1744 M14202 GO_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of endocytosis. 238/321 Gene Ontology BP GO:0030100 0.0044701679825886 0.0116264346690803 1805 2004.36363636364 1892 0.000407206983137201 670 1.20280423213089 1.15715901234814 1 7.94484855644354 1803 1381 670 773 3225 1892 2452 4044 2018 758 3032 1745 M14257 GO_HEAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_DEVELOPMENT.html The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. 787/1144 Gene Ontology BP GO:0060322 4.05469334530068e-05 0.000380146911810331 1700 2081.63636363636 1892 4.05476732962214e-06 191 1.19403415192417 1.24068835044949 1 13.9511379763848 1699 1892 4484 1719 1375 2402 2429 2905 2069 191 1733 1746 M12124 GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. 35/40 Gene Ontology BP GO:0060674 0.000262525665497119 0.00153651814032465 2835 1829.81818181818 1893 2.38688179890396e-05 75 1.07528037374546 -0.626594245744892 -1 10.3325447602503 2835 219 1893 120 215 4560 4240 1216 75 1916 2839 1747 M12982 GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. 25/32 Gene Ontology BP GO:0090049 0.00188655486438394 0.00629257332184836 4385 2643.54545454545 1894 0.000171652234280291 230 1.17792807400522 1.24768235829339 1 8.85405911058951 4381 1682 1894 230 501 4320 4631 4082 1269 1436 4653 1748 M14277 GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 43/56 Gene Ontology BP GO:0051353 0.189063374752048 0.232175213175317 955 2028.27272727273 1894 0.0188710665722594 952 1.12957040215752 1.16053410210777 1 2.43851950961344 952 2670 1781 3633 2681 1862 1403 1972 1894 1164 2299 1749 M11518 GO_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_CHECKPOINT.html A cell cycle checkpoint that originates from the mitotic or meiotic spindle. 28/31 Gene Ontology BP GO:0031577 0.0288245617686491 0.0477637770333064 1440 2295.90909090909 1895 0.00265539084349292 979 0.922974992697218 -0.923031617679374 -1 4.1575774003082 1438 4122 3800 3130 2400 1683 1895 1002 979 3688 1118 1750 M12059 GO_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 87/132 Gene Ontology BP GO:0043542 0.00165941251854505 0.00575782732944825 3795 2157.45454545455 1895 0.000150969590993629 78 1.21478448064057 -1.24225266547576 -1 9.29161972162 3792 78 549 608 589 3980 4585 3876 2738 1042 1895 1751 M14163 GO_RESPONSE_TO_PROGESTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROGESTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. 51/72 Gene Ontology BP GO:0032570 0.00368731106780541 0.0101761912209363 1485 1785.18181818182 1895 0.000335773247980025 447 1.35397778066258 1.33262655897379 1 9.21258131717069 1482 2149 914 2170 4190 1895 2129 1056 2039 447 1166 1752 M10440 GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. 25/29 Gene Ontology BP GO:0045648 0.00389203913220047 0.0105780713096547 3645 2120.72727272727 1896 0.000354449243129454 340 0.978693837679817 1.00289755022536 1 6.59987610587221 3641 340 2491 1361 1826 3476 1896 382 1259 2335 4321 1753 M11901 GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of cell proliferation. 821/1274 Gene Ontology BP GO:0008284 3.78275764931615e-06 5.50036604445877e-05 1470 2030.63636363636 1897 3.78276408849653e-07 132 1.23780415014838 1.28668186551607 1 18.0159457668741 1467 1305 4332 2297 3337 2080 1781 1511 2198 132 1897 1754 M11703 GO_ENDOCARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. 13/14 Gene Ontology BP GO:0003157 0.09357461487082 0.126460262269511 1885 2463.63636363636 1898 0.00889173832308703 1526 1.07745766988901 1.07745766988901 1 3.29753285767811 1882 3911 3230 4068 1717 1581 1888 2120 1898 3279 1526 1755 M14494 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. 31/67 Gene Ontology BP GO:0002833 0.0294628449082517 0.0485448361749629 870 2459.09090909091 1898 0.00271499794686996 865 0.737927626664579 0.693475106512764 1 3.30411392804968 869 4107 3519 4229 1261 1108 865 1554 3579 4061 1898 1756 M13843 GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. 5/11 Gene Ontology BP GO:0002676 0.126399779320951 0.163462527287489 1905 2250.18181818182 1901 0.0134223481664503 404 1.78181362211712 1.22276734568822 1 4.78113612569076 1901 1870 4453 1076 4347 2723 1163 2105 404 1349 3361 1757 M15922 GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX.html The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. 13/16 Gene Ontology BP GO:0030150 0.0159243343088496 0.0296977665487283 650 2341.63636363636 1901 0.00145825288344043 646 0.553890267370901 -0.553890267370901 -1 2.88157333418343 646 3233 3781 3761 1050 1020 1462 1282 3002 4620 1901 1758 M13124 GO_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that modulates the frequency, rate, or extent of mast cell activation. 37/56 Gene Ontology BP GO:0033003 0.00131738256804728 0.0048687697292486 160 1504.45454545455 1902 0.000119833826564324 107 0.973614199614157 1.02401949187771 1 7.68730745722671 158 2189 2724 1902 3690 172 107 206 1935 2810 656 1759 M16087 GO_SOMITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITE_DEVELOPMENT.html The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 86/123 Gene Ontology BP GO:0061053 0.0411876542153234 0.0636909787517115 715 1759.09090909091 1902 0.00381632653771146 514 1.26727950161793 1.27053879756774 1 5.17098291459079 714 2592 1455 3796 2668 514 634 2299 1902 2191 585 1760 M12536 GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of T cell death by apoptotic process. 32/41 Gene Ontology BP GO:0070232 0.0606024095547061 0.0877631533327256 4610 2578.27272727273 1903 0.00566719600397527 1136 1.36453541467893 -1.44133605403441 -1 4.91907612087437 4607 2705 1136 1861 1903 2679 4366 4377 1899 1313 1515 1761 M12615 GO_CHLORIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_TRANSPORT.html The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 60/116 Gene Ontology BP GO:0006821 0.0992947098737207 0.133079111773474 3485 2184.18181818182 1903 0.0094619663732484 865 1.30303431367068 -1.29408892887593 -1 3.89143272784808 3485 865 1592 1966 1786 1903 4079 3346 1213 2781 1010 1762 M12739 GO_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of neuron differentiation. 614/801 Gene Ontology BP GO:0045664 0.000108136496143442 0.000794880120940654 1640 2053.54545454545 1903 1.0814175857966e-05 234 1.20626566778151 1.28834818732741 1 12.7729856913297 1639 1903 4385 1204 3314 1328 2374 3545 2214 234 449 1763 M11347 GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM.html The process in which an organism effects a change in the structure or processes of a second organism. 98/206 Gene Ontology BP GO:0035821 0.142852962617163 0.181378927630538 990 2039.54545454545 1904 0.0139155261845373 679 1.17276862832147 1.33269872720574 1 2.96213288928428 988 2996 3123 1904 2229 1646 1184 3230 679 2918 1538 1764 M12372 GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 44/55 Gene Ontology BP GO:0006220 0.0541815572141458 0.0798817445238974 360 2114.09090909091 1904 0.00505125829687031 360 0.82621220794163 -0.816344638885911 -1 3.08967717989465 360 2668 3849 2105 4314 603 1054 1904 916 3716 1766 1765 M16477 GO_INNERVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNERVATION.html The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. 26/39 Gene Ontology BP GO:0060384 0.000737341087643039 0.00320340623791135 200 2083.72727272727 1904 6.70534842946779e-05 147 1.56418956071428 1.56418956071428 1 13.3290293659686 199 4150 1904 4037 2887 675 799 147 3954 3264 905 1766 M15078 GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. 17/18 Gene Ontology BP GO:1904152 0.000554563550002479 0.00262234166479831 2915 1989.45454545455 1905 5.04275809633312e-05 309 0.753858561511868 0.880594689888642 1 6.64241463605284 2915 434 3239 1905 309 1648 1041 2844 555 3970 3024 1767 M10094 GO_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. 124/154 Gene Ontology BP GO:0016358 0.00449814165751329 0.0116618143057252 1910 2136.36363636364 1906 0.000409760455862023 671 1.19395571885346 1.30534751825473 1 7.88093671856645 1906 755 671 764 2754 2865 2142 4404 1800 1521 3918 1768 M15451 GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 558/721 Gene Ontology BP GO:0010720 0.000417945068540528 0.00214173833030736 1345 2111.72727272727 1907 4.18023694489643e-05 291 1.17788937967427 1.23703613595408 1 10.738719457389 1342 1907 4557 1035 3917 1339 2022 2665 2923 291 1231 1769 M12447 GO_EATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EATING_BEHAVIOR.html The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. 21/46 Gene Ontology BP GO:0042755 0.0016885474415287 0.00582199348953458 2870 1657.90909090909 1910 0.00015362225749112 107 1.28065441316453 -0.959878878444578 -1 9.77494852450122 2869 352 1262 107 481 3737 2694 2489 395 1941 1910 1770 M13490 GO_INOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. 11/13 Gene Ontology BP GO:0006020 0.0139198497021725 0.0266539344297155 3695 2276.63636363636 1910 0.00127351923511697 235 0.881973428127383 -0.558756688944819 -1 4.73632921748076 3693 1214 3080 611 1009 4638 3767 1910 235 3098 1788 1771 M16723 GO_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_TRANSPORT.html The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 65/102 Gene Ontology BP GO:0015833 0.256151486097158 0.30482681964452 1790 2232.63636363636 1910 0.0265429993734615 1503 1.15683260934984 1.16690081979993 1 2.02998425564063 1786 1532 1727 1503 2186 3108 1767 2368 3688 1910 2984 1772 M10653 GO_CELLULAR_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 520/821 Gene Ontology BP GO:0071396 1.00904773932872e-05 0.000128986239865289 1095 1972 1913 1.00905232115603e-06 154 1.22939449315599 1.28179013260619 1 16.3376377707513 1092 1913 4253 2057 3094 939 1933 1680 3053 154 1524 1773 M12081 GO_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSPORT.html The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 374/632 Gene Ontology BP GO:0006820 1.52363680388673e-11 1.07416394674015e-09 4200 2126 1913 1.38512436717934e-12 46 1.26033725093585 -1.28637178567574 -1 38.6366940311438 4200 621 46 242 1913 3756 4052 3530 1188 60 3778 1774 M15621 GO_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_P38MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of p38MAPK cascade. 38/45 Gene Ontology BP GO:1900744 0.0718694962677278 0.101351965682496 1915 2117.18181818182 1913 0.00675733195479172 663 1.34578655689092 1.46735376294838 1 4.5636758341313 1913 2191 1719 663 1586 1752 1617 4300 2959 2515 2074 1775 M11017 GO_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 38/43 Gene Ontology BP GO:0060996 0.055179504056273 0.0811730105513241 3025 2289.90909090909 1914 0.00514673909233418 956 1.00027432018684 -0.985508958196149 -1 3.71902428277765 3024 1614 2496 1914 1816 1863 3112 1326 3855 3213 956 1776 M11882 GO_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 527/754 Gene Ontology BP GO:0010035 0.000252451032666554 0.00149257262388497 1245 2204.45454545455 1914 2.52479716438536e-05 269 1.19252574149134 1.18819239157374 1 11.511718839293 1243 1914 4331 3219 1967 1833 1820 2942 2962 269 1749 1777 M11646 GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM.html The process in which the anatomical structures of embryonic epithelia are generated and organized. 165/203 Gene Ontology BP GO:0016331 0.182423670063359 0.224733210697593 1920 2167.81818181818 1916 0.018143480581069 1051 1.20987841181858 1.16350015912257 1 2.6711725472565 1916 1412 1447 1051 2030 3439 3053 3993 1246 1878 2381 1778 M16487 GO_ADIPOSE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADIPOSE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. 45/50 Gene Ontology BP GO:0060612 0.13625455794404 0.174329589833376 2470 2037.72727272727 1917 0.0132278402174668 918 1.18077808216093 1.15531681908639 1 3.05193585431915 2470 918 1800 1574 1906 2529 1153 2143 1917 2278 3727 1779 M10877 GO_MODIFIED_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSPORT.html The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 27/36 Gene Ontology BP GO:0072337 0.00577426225782821 0.0134540021460564 1920 1849.36363636364 1919 0.000526315789473684 67 1.46840765507407 -1.68535037925368 -1 9.38326714744574 3473 313 779 67 4481 1919 2512 1920 363 677 3839 1780 M11920 GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. 69/99 Gene Ontology BP GO:1990542 0.00164132746230389 0.00571638973211078 745 2067.81818181818 1919 0.000149323024382486 476 0.712984681585588 -0.598619617986433 -1 5.45670518011287 743 2116 3948 1893 476 1185 1034 2825 1919 4090 2517 1781 M14159 GO_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 1127/1567 Gene Ontology BP GO:0009628 2.72108344479335e-05 0.00028261609974606 1920 1971.63636363636 1919 2.72111676469558e-06 182 1.19912810626995 1.23726605997562 1 14.5385637115657 1919 1278 4477 1217 2692 1350 2367 1618 2661 182 1927 1782 M15161 GO_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORT.html The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 46/72 Gene Ontology BP GO:0015918 0.00235452523885556 0.00729887137667884 3520 2034 1919 0.000214277175011642 595 1.55315847252102 -1.67322855207224 -1 11.3358064744069 3517 906 595 1053 1199 2843 4448 1919 2057 1063 2774 1783 M14237 GO_REGULATION_OF_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. 459/729 Gene Ontology BP GO:0044057 1.99141071848993e-17 7.72169506094469e-15 1255 1891.18181818182 1920 1.81037338044539e-18 8 1.29046070817407 1.19622155281286 1 62.2529926263567 1252 1920 8 2254 3973 1507 2229 2852 3119 38 1651 1784 M16461 GO_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIOR.html The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 512/825 Gene Ontology BP GO:0007610 7.16284452341508e-06 9.66049726592765e-05 1635 1969.36363636364 1921 7.16286761137357e-07 142 1.30858060860838 1.26399099126323 1 17.9523220845098 1635 1328 4625 708 2184 1055 2089 4017 1921 142 1959 1785 M11116 GO_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_PROLIFERATION.html The expansion of a T cell population by cell division. Follows T cell activation. 40/59 Gene Ontology BP GO:0042098 0.0588608090710855 0.0855071322534377 2325 2134.45454545455 1922 0.00549975089306428 742 1.00250204676509 0.907150209679954 1 3.64990110496451 2325 924 2465 1327 3092 1376 742 4398 1384 1922 3524 1786 M11178 GO_REGULATION_OF_HORMONE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_LEVELS.html Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. 429/704 Gene Ontology BP GO:0010817 6.40898465238046e-11 3.82320584455465e-09 1280 1645.63636363636 1922 5.82634968415195e-12 54 1.30901418642104 1.24782353452579 1 37.661766554473 1278 1922 54 1956 2671 1174 1644 3264 2139 71 1929 1787 M14255 GO_CELLULAR_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCOSE_HOMEOSTASIS.html A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. 81/105 Gene Ontology BP GO:0001678 0.00152794387625455 0.00540648125947713 145 1581.09090909091 1922 0.000139000554247249 28 1.10300638981395 1.12575795740499 1 8.53878980425507 141 3009 2585 3314 3377 28 53 489 1922 2194 280 1788 M11002 GO_SINGLE_ORGANISM_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELL_ADHESION.html The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. 478/734 Gene Ontology BP GO:0098602 5.54870594746977e-11 3.35300373682816e-09 1605 1988.27272727273 1923 5.04427813419066e-12 53 1.23503702105903 1.20866030895991 1 35.7734173692703 1601 2463 53 2269 3489 1807 1923 1330 3405 144 3387 1789 M12183 GO_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIVISION.html The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. 40/47 Gene Ontology BP GO:0017145 0.400723721935882 0.452580901910465 1925 2220 1923 0.045481652690313 235 1.20476921093062 1.21609530190916 1 1.40753916473397 2240 235 1806 1379 4566 2638 1921 3441 644 1923 3627 1790 M13026 GO_RESPONSE_TO_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 935/1432 Gene Ontology BP GO:0009725 2.18408582398904e-11 1.43134525901704e-09 1695 1909.63636363636 1923 2.1840858240105e-12 26 1.21918374284389 1.20806738651826 1 36.8550695444283 1691 579 4401 716 2908 1416 1965 2660 1923 26 2721 1791 M12236 GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION.html A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. 15/31 Gene Ontology BP GO:0072378 0.000275655632964109 0.0016032820752275 1780 1866.36363636364 1924 2.50627434661552e-05 218 1.98268903767152 -2.38047374837131 -1 18.9357629354814 1780 2843 786 2977 218 1924 2221 3449 1527 849 1956 1792 M15197 GO_GLYCEROLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. 28/46 Gene Ontology BP GO:0046503 0.04385986937785 0.0669334116809236 1210 2007.81818181818 1924 0.00406904405280659 332 1.28923515874745 1.36987804100145 1 5.16570012201413 2290 332 1210 2743 1924 3249 1570 1209 3037 1717 2805 1793 M13035 GO_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_GROWTH.html Any process that modulates the frequency, rate, extent or direction of cell growth. 432/558 Gene Ontology BP GO:0001558 4.92922695097791e-07 9.43855679131696e-06 1885 1899.81818181818 1925 4.48111641399999e-08 94 1.26655615717297 1.27341763756927 1 21.7494475767412 1883 2942 226 1759 3711 2492 2417 2007 1925 94 1442 1794 M15313 GO_SCHWANN_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 40/42 Gene Ontology BP GO:0014037 0.00462227435199822 0.0119019316413848 895 1790.27272727273 1925 0.000421092233548324 139 1.01589368716604 1.00205367909522 1 6.67327026989283 892 1604 2837 2455 2327 487 139 1442 2248 3337 1925 1795 M12274 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that stops, prevents or reduces the rate of gene expression. 75/125 Gene Ontology BP GO:0045814 0.0227503421135986 0.0393866077063887 1785 2292.54545454545 1926 0.00208991529651011 389 1.15656415690745 -1.35473426359082 -1 5.54365486086104 1784 3337 3405 3139 1505 1486 3556 1926 908 3783 389 1796 M11688 GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle tissue development. 119/167 Gene Ontology BP GO:1901861 0.0645759919788804 0.0922825831319811 2220 1875.72727272727 1927 0.0060502926327736 15 1.16040842149106 1.21008347015147 1 4.09509567005888 2216 15 1152 447 3416 1948 1880 3796 1927 1972 1864 1797 M14270 GO_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_ELONGATION.html The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. 109/123 Gene Ontology BP GO:0006414 0.010523436681553 0.0214855422901562 60 1948.54545454545 1927 0.000961283089105387 56 0.608159014360238 -0.564603745851863 -1 3.45724482699312 56 2053 4183 2186 1270 978 860 1927 1227 4410 2284 1798 M11635 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 30/31 Gene Ontology BP GO:1902230 0.00463240820488484 0.0119086162305686 1930 1809.36363636364 1929 0.000422017385534323 415 1.28835879837284 1.56985868550325 1 8.46484294230673 1929 2225 2014 1323 937 3414 2391 415 1100 3116 1039 1799 M14980 GO_VACUOLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_FUSION.html Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. 24/25 Gene Ontology BP GO:0097576 0.00157411729669098 0.0055377536451456 1330 1732 1929 0.000143204065409661 316 0.88482820390012 -0.729729489608191 -1 6.81616164351968 1328 2250 3517 1042 469 853 2124 1929 316 3125 2099 1800 M15077 GO_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_RECOGNITION.html The process in which a cell in an organism interprets its surroundings. 128/345 Gene Ontology BP GO:0008037 6.77836844598775e-05 0.000562547250526393 1695 2146.36363636364 1933 6.16234300156235e-06 326 1.41699832955694 1.38166626191625 1 15.7336558002862 1692 3989 326 2986 2296 1602 1523 3887 2772 604 1933 1801 M16464 GO_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLATION.html The covalent attachment of a mannose residue to a substrate molecule. 29/31 Gene Ontology BP GO:0097502 0.0365656651151676 0.0579693491587308 525 2263.54545454545 1933 0.00338072209552389 524 0.71234966299794 -0.642059010150454 -1 3.00155020379357 524 3447 3868 3733 3316 539 924 1132 1933 4017 1466 1802 M14234 GO_NEGATIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GROWTH.html Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. 244/323 Gene Ontology BP GO:0045926 0.000810655673578846 0.00341974691673832 1935 1893.27272727273 1934 7.37231398225712e-05 483 1.25989377559262 1.32932601527249 1 10.6116842058918 1933 3288 483 2340 2031 3317 2600 1934 1424 609 867 1803 M13891 GO_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 53/61 Gene Ontology BP GO:0071616 0.00443765662679106 0.0115612633171662 2010 1927.09090909091 1936 0.00040423938707097 147 0.998393975322736 1.12467760255491 1 6.60118437421105 2010 147 1936 693 703 2728 3016 4385 1094 969 3517 1804 M11861 GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 66/115 Gene Ontology BP GO:0033555 0.000214355869997143 0.00132986381746228 1495 1848.45454545455 1937 1.94887962273324e-05 200 1.66575470692716 1.60274615908788 1 16.3696226997605 1491 2610 398 3222 1489 3075 2564 200 2177 1170 1937 1805 M15448 GO_THIOESTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 53/61 Gene Ontology BP GO:0035384 0.00443765662679106 0.0115612633171662 2015 1927.63636363636 1937 0.00040423938707097 148 0.998393975322736 1.12467760255491 1 6.60118437421105 2011 148 1937 694 704 2729 3017 4380 1095 971 3518 1806 M10798 GO_ENDOCARDIAL_CUSHION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_DEVELOPMENT.html The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 45/53 Gene Ontology BP GO:0003197 0.00014759121839763 0.00101438986588504 1735 1884.18181818182 1938 1.34182837061432e-05 371 1.47445403709472 1.47365421982933 1 15.0813001587653 1732 2160 371 2153 2808 1938 1365 3069 2213 1013 1904 1807 M15554 GO_RENAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_ABSORPTION.html A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). 18/35 Gene Ontology BP GO:0070293 0.0120186270503765 0.0238070122032361 815 1878.63636363636 1938 0.00109861741406018 815 1.6809974005617 -1.73872110035517 -1 9.31880652060785 2098 2810 815 1028 1938 1107 2216 3448 3317 815 1073 1808 M10049 GO_REGULATION_OF_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING_BY_RNA.html Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. 21/27 Gene Ontology BP GO:0060966 4.2854866051493e-05 0.000397218509437444 4575 2383.54545454545 1939 3.89597280590558e-06 90 1.0196101202601 -0.985441389836939 -1 11.8450978905448 4575 403 2931 904 90 4464 4505 1691 370 1939 4347 1809 M14533 GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 498/622 Gene Ontology BP GO:0010975 8.20622274166262e-06 0.000108785055318963 1940 2000.81818181818 1939 7.46023031987649e-07 252 1.1917522649452 1.2761885137807 1 16.1384876486404 1939 1915 252 1195 3506 2333 2799 3879 2081 382 1728 1810 M16156 GO_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the cell. 599/901 Gene Ontology BP GO:0019725 1.21338388662272e-06 2.01638400873411e-05 1750 2006.54545454545 1939 1.21338454915843e-07 116 1.19629154869529 1.28366880359646 1 19.1939043592587 1746 1319 4599 464 3809 1668 2001 1939 2233 116 2178 1811 M11123 GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS.html A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism. 1225/1598 Gene Ontology BP GO:0044711 0.0835420377101781 0.114986155380469 1575 1940.63636363636 1940 0.00868596517251937 571 1.0583695256795 -1.0234179630404 -1 3.388400457355 1572 571 4278 923 1749 805 2092 2632 1940 2625 2160 1812 M13564 GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 192/252 Gene Ontology BP GO:0010952 0.00512622098771611 0.0128445375637281 1875 1849.63636363636 1941 0.00046710951894459 693 1.12589143643477 1.27129121080783 1 7.26956748875755 1874 1982 693 1309 3061 2767 2082 1553 2138 946 1941 1813 M14851 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell migration. 130/152 Gene Ontology BP GO:0010634 0.00723975263215381 0.0160718363537269 1750 2114.81818181818 1941 0.000660335229959639 549 1.20155421117541 1.35522596032177 1 7.35891099797824 1750 1440 739 2446 3021 3530 2852 1941 1721 549 3274 1814 M15756 GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. 35/50 Gene Ontology BP GO:1904837 0.0298609146523885 0.0490446905257885 2065 2124 1942 0.00275219037966097 1030 0.872624829796645 0.737441987645354 1 3.89590153398691 2064 2206 3574 1942 1263 1613 1366 1475 1030 3668 3163 1815 M14644 GO_PEPTIDYL_TYROSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_MODIFICATION.html The modification of peptidyl-tyrosine. 167/243 Gene Ontology BP GO:0018212 0.00450449130123993 0.0116635680984335 665 2005.72727272727 1943 0.000410340068523282 665 1.16652224826894 1.22807423855407 1 7.69935130323252 665 1411 672 2631 4634 1943 1195 2335 3157 1252 2168 1816 M12261 GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. 34/46 Gene Ontology BP GO:0030513 0.0398458967107779 0.0620386872092917 1285 2342.63636363636 1944 0.00368967482755897 572 1.2218561793924 1.12860308569367 1 5.03294335798823 1281 3423 1944 3151 4332 1472 1274 3898 1447 2975 572 1817 M13168 GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 229/292 Gene Ontology BP GO:0009141 0.0185692314513792 0.0335153739112753 80 1944 1944 0.00170253124002237 77 0.788094245889693 -0.68743640323905 -1 3.96299744944936 77 1958 3911 1467 2529 422 468 1944 2401 4271 1936 1818 M15829 GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING.html Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. 21/27 Gene Ontology BP GO:0060147 4.2854866051493e-05 0.000397218509437444 4580 2373.45454545455 1945 3.89597280590558e-06 91 1.0196101202601 -0.985441389836939 -1 11.8450978905448 4576 404 2932 905 91 4465 4506 1565 371 1945 4348 1819 M11818 GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrate derivative. 962/1241 Gene Ontology BP GO:1901135 0.000667924269416709 0.0029940767105934 2170 1856.54545454545 1946 6.68125109654444e-05 6 1.10333672335862 -0.982002459770923 -1 9.50950495874478 2166 577 4327 6 1946 743 2293 3765 1615 319 2665 1820 M14584 GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. 387/605 Gene Ontology BP GO:0051346 0.000354092722028429 0.00190693684675727 1585 2209.09090909091 1946 3.21954296850447e-05 425 1.1552879097719 1.17055037235021 1 10.7316514015627 1582 1929 425 2496 2158 1884 1946 3394 3695 1750 3041 1821 M15089 GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. 137/213 Gene Ontology BP GO:0045834 0.000228715087646849 0.00139477234969959 1950 1896.36363636364 1946 2.07944426045143e-05 200 1.15945310295281 1.18802870912894 1 11.3088377437168 1946 741 400 200 4408 2028 2389 3886 1588 386 2888 1822 M15192 GO_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 65/99 Gene Ontology BP GO:0043331 0.127590486212871 0.16472767268271 840 2294.18181818182 1946 0.0123320869480982 527 1.26146326543726 1.41881288987898 1 3.36732637120766 836 3710 2796 4218 3758 1552 1102 3183 527 1608 1946 1823 M10507 GO_POSITIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DEATH.html Any process that activates or increases the frequency, rate or extent of neuron death. 94/112 Gene Ontology BP GO:1901216 0.0435889486963754 0.0666949616192814 1265 2011.63636363636 1947 0.00404339323412332 602 1.0438922008212 1.10231615348378 1 4.18616395635228 1265 2998 2622 1947 3050 997 602 1672 2305 2954 1716 1824 M10201 GO_INORGANIC_ION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_IMPORT_INTO_CELL.html The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 17/26 Gene Ontology BP GO:0099587 0.00123781167969787 0.00463357823462124 2505 1985.18181818182 1949 0.000112591697564922 428 1.3836017877922 1.59710364257469 1 11.0306298849851 2503 1763 1770 2351 428 3095 1949 3312 1072 1045 2549 1825 M12093 GO_INORGANIC_CATION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_IMPORT_INTO_CELL.html The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 17/26 Gene Ontology BP GO:0098659 0.00123781167969787 0.00463357823462124 2505 2010.09090909091 1950 0.000112591697564922 429 1.3836017877922 1.59710364257469 1 11.0306298849851 2504 1764 1771 2352 429 3096 1950 3575 1073 1047 2550 1826 M13125 GO_MIDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). 124/187 Gene Ontology BP GO:0030901 0.00847587665944802 0.0181575755508341 3505 1970.72727272727 1950 0.000773518968154314 150 1.12786266591626 -1.07615108900647 -1 6.70258966080077 3502 1443 2173 2152 1067 150 2845 2983 1792 1950 1621 1827 M14397 GO_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 254/323 Gene Ontology BP GO:0006732 0.0127010691434202 0.024820694970321 3110 2212.72727272727 1950 0.00116136302823378 666 1.02621372891168 -0.977911366833674 -1 5.62124611646663 3106 666 3112 1440 980 1950 2881 3208 1571 1911 3515 1828 M14849 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. 269/358 Gene Ontology BP GO:2000116 0.0960994887946291 0.129421395473635 2280 1961.09090909091 1950 0.00914303489134433 1254 1.07909508599715 -0.962464611843297 -1 3.26547479317613 2277 1950 1254 1344 1848 2259 2276 1653 2292 1544 2875 1829 M15947 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS.html Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. 33/37 Gene Ontology BP GO:1901522 0.0262498077083028 0.0443763898259863 645 1970.36363636364 1951 0.00241530429477504 470 0.995021430322411 1.05828493825362 1 4.59162604053739 642 2704 3241 1951 3821 1239 2162 963 470 2944 1537 1830 M11702 GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND.html A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. 34/47 Gene Ontology BP GO:0001702 0.017557839742709 0.0320504622686641 1410 2301 1952 0.00160905017379981 793 1.2887277715981 1.21962912666482 1 6.57276946768478 1407 3093 1516 3755 4007 1952 1733 816 3624 2615 793 1831 M13847 GO_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). 193/553 Gene Ontology BP GO:0002250 0.000183894040959899 0.0011769724519758 1030 1852.27272727273 1952 1.67190376482642e-05 386 1.23169828231107 1.26627783962761 1 12.324667334326 1027 1984 386 941 4210 1609 1995 2752 1952 841 2678 1832 M11744 GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. 36/82 Gene Ontology BP GO:0021515 0.0223048734967734 0.0387111437450528 1355 2072.54545454545 1953 0.00204857054901064 409 1.2444292119901 1.02755905223442 1 5.99758386076493 1352 3082 1684 3286 1929 1303 409 2545 2862 2393 1953 1833 M10240 GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that activates or increases the frequency, rate or extent of protein binding. 115/132 Gene Ontology BP GO:0032092 0.0133524238757977 0.0258010084277768 780 1844.45454545455 1954 0.00122128717034779 777 1.14566067840107 1.15658035336164 1 6.21088264751661 777 2564 2849 2904 997 1954 1056 863 3220 2050 1055 1834 M12689 GO_RESPONSE_TO_INACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. 13/23 Gene Ontology BP GO:0014854 0.00381643338291092 0.0104198651086309 2210 1938.27272727273 1955 0.000347551821412289 379 1.15636323219818 0.95343388141176 1 7.82580874801544 2209 1202 1955 2788 1322 3104 2518 379 1481 3283 1080 1835 M15105 GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 238/306 Gene Ontology BP GO:0009123 0.00450449857573287 0.0116635680984335 35 1970.36363636364 1956 0.000410340732560609 35 0.730824949831366 -0.691824290554928 -1 4.81965287222511 35 1956 4114 2012 2560 274 417 1272 3156 4373 1505 1836 M11914 GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. 51/66 Gene Ontology BP GO:0016339 0.00237621613168711 0.00733593836475714 1960 1956.81818181818 1960 0.000216253324204006 598 1.33897787076391 1.05092172106693 1 9.76105681551347 1960 1571 598 2479 1776 1577 2114 968 3658 1986 2838 1837 M12765 GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive nitrogen species. 19/26 Gene Ontology BP GO:2001057 1.32700879626236e-06 2.17414504542562e-05 3805 1807.45454545455 1960 1.20637236063265e-07 8 1.20014068866998 -1.25077026049358 -1 19.1214583297072 3804 411 1003 305 8 3326 3304 2474 1960 887 2400 1838 M16751 GO_HISTONE_H3_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_DEACETYLATION.html The modification of histone H3 by the removal of one or more acetyl groups. 21/23 Gene Ontology BP GO:0070932 0.00218917243161189 0.00692469022725366 3145 1979.18181818182 1960 0.000199213988122905 283 0.858297818143633 -0.833390276251945 -1 6.32662861337614 3141 1064 3492 1908 533 2205 2681 754 283 3750 1960 1839 M12386 GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION.html Any process that activates or increases the frequency, rate or extent of vasoconstriction. 23/45 Gene Ontology BP GO:0045907 0.00468276485632937 0.0119982956368395 2705 2122.63636363636 1961 0.000426614733016147 680 1.53852226564999 -1.73777708487788 -1 10.0934117045916 2701 3138 680 3291 1126 2584 3833 1961 1920 908 1207 1840 M14020 GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 154/231 Gene Ontology BP GO:0072330 1.20956938570875e-05 0.00014889223152653 1965 1957.18181818182 1961 1.09961457820366e-06 263 1.34690294060291 1.29102436258556 1 17.6132243300873 1961 2533 263 938 4012 2286 1604 1561 2885 327 3159 1841 M16547 GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION.html Any process that modulates the frequency, rate or extent of sister chromatid segregation. 75/81 Gene Ontology BP GO:0033045 0.153876444598178 0.193981873940754 1755 2176.18181818182 1961 0.0150752034509722 475 0.895135311619258 -0.882284794552032 -1 2.16908766039251 1755 1513 3962 1123 1940 2464 1961 2584 475 4068 2093 1842 M15027 GO_SCHWANN_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DEVELOPMENT.html The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 32/34 Gene Ontology BP GO:0014044 0.00754580383290011 0.0165463884340949 715 2108.54545454545 1964 0.000688346384791298 190 0.934189439189559 0.921254361355897 1 5.67870039683899 711 3106 3281 3845 1964 563 190 1102 3431 3839 1162 1843 M14235 GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 17/20 Gene Ontology BP GO:0010745 0.00201696602930074 0.0065537310993969 4310 2347.18181818182 1966 0.000183528869655642 477 1.82831817830023 2.00346668457223 1 13.6383001946917 4309 477 1444 1536 517 4007 3559 1966 1466 2555 3983 1844 M16792 GO_LUNG_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_ALVEOLUS_DEVELOPMENT.html The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. 48/56 Gene Ontology BP GO:0048286 0.00235051964797371 0.00729131194801444 2400 1855.90909090909 1966 0.000213912249852831 187 1.45536972497453 1.35713029221046 1 10.6236582443915 2400 187 594 779 1966 2339 1591 4061 2594 472 3432 1845 M12876 GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-8 production. 66/109 Gene Ontology BP GO:0032677 0.0433092642806912 0.0663980252711881 1050 1965 1969 0.0040169195920563 951 1.2319891211923 1.31165914499429 1 4.95054454305255 1050 3346 1056 3174 2612 951 1246 1413 2403 1969 2395 1846 M13111 GO_OPTIC_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPTIC_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. 18/26 Gene Ontology BP GO:0021554 0.206040946184845 0.249728711278479 1970 2169.63636363636 1969 0.0207564111972138 268 1.28846205086 1.32608649614146 1 2.64359946502615 1969 1722 1559 422 3812 4108 3006 2636 268 1186 3178 1847 M14226 GO_MONOSACCHARIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSPORT.html The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 55/83 Gene Ontology BP GO:0015749 0.0705804426903123 0.0997299726201102 2700 2076.90909090909 1970 0.00663200323940531 358 1.27341126509747 1.2309291890984 1 4.34817595480334 2699 1552 1474 1267 2241 3021 2824 1970 358 848 4592 1848 M16138 GO_DEFINITIVE_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFINITIVE_HEMOPOIESIS.html A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. 17/21 Gene Ontology BP GO:0060216 3.02426796879021e-05 0.000305911279538714 3740 2426.90909090909 1970 2.74937231201082e-06 71 1.45276007677974 -1.29528778038194 -1 17.445069079269 3737 1140 1603 1277 71 3656 4638 3163 1970 1485 3956 1849 M12075 GO_COFACTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. 23/37 Gene Ontology BP GO:0051187 0.0572990053537886 0.0837087195953464 1995 1802.90909090909 1971 0.005349831631627 656 1.26566453971528 -1.15142088789816 -1 4.65076748306492 1994 2265 2546 2024 1813 656 727 1971 1557 2605 1674 1850 M13829 GO_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENETIC_IMPRINTING.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 20/23 Gene Ontology BP GO:0071514 0.0137131480069563 0.0263666436679206 1975 2381.27272727273 1971 0.00125448899250328 283 1.09879078335453 0.90117283966192 1 5.92097293682627 1971 3173 2827 4210 1688 1626 1317 1070 4331 3698 283 1851 M14526 GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 146/175 Gene Ontology BP GO:0090263 0.00418708529198086 0.011113809391664 4005 2545.54545454545 1971 0.000381370503373609 682 1.10728804640919 -0.990202033720147 -1 7.3872303170182 4004 732 1854 880 682 3122 4648 4620 1537 1971 3951 1852 M16107 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 984/1448 Gene Ontology BP GO:0051241 5.49623139362409e-14 8.52465489151096e-12 1370 2089.45454545455 1971 5.49623139362421e-15 10 1.30540581448773 1.29886867507926 1 49.3929862650229 1368 2438 4593 1971 2300 1815 1853 1757 2627 10 2252 1853 M13958 GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 12/18 Gene Ontology BP GO:0001574 0.000469505524724399 0.00232364264403131 2510 2046.45454545455 1973 4.26914320543303e-05 99 1.92090427942401 2.04034786130725 1 17.2869428471565 2508 1838 924 1973 4042 3024 2546 99 915 1372 3270 1854 M14668 GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. 243/297 Gene Ontology BP GO:2001234 0.112049849171709 0.147404000055403 1525 2421.09090909091 1973 0.0107454573659507 1518 1.06910878786794 1.16880018959074 1 3.02862437627621 1523 4290 1973 3655 1792 1818 2083 2526 3542 1912 1518 1855 M10464 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. 56/88 Gene Ontology BP GO:0043551 0.0421524138263828 0.0649091632348636 2640 2226.63636363636 1974 0.00390749212704863 149 1.08481901733717 -0.977113516480586 -1 4.3944219853727 2638 149 1052 677 4105 2762 1974 4060 1968 1128 3980 1856 M14370 GO_RESPONSE_TO_CORTICOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. 26/34 Gene Ontology BP GO:0051412 0.00439284727223028 0.0114702123219346 445 2022.27272727273 1975 0.000400149389382764 133 0.89672690310026 0.948780984199219 1 5.93842358509539 442 3128 2224 4166 983 413 133 1530 4408 2843 1975 1857 M16371 GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 1557/2142 Gene Ontology BP GO:0051174 0.000337938618360109 0.00185924201533402 1685 1983.63636363636 1975 3.37990020491335e-05 283 1.15793151817983 1.20201877678672 1 10.7997821978621 1683 1260 4619 934 2605 1391 1975 2388 2439 283 2243 1858 M12114 GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of epithelial cell proliferation. 327/422 Gene Ontology BP GO:0050678 9.07613674854273e-09 2.83431303966237e-07 1330 2065.63636363636 1976 8.2510334418059e-10 111 1.33762815368239 1.36208215907339 1 29.9331285087527 1330 3628 111 3321 4040 1976 1672 2897 2426 235 1086 1859 M14753 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 810/1268 Gene Ontology BP GO:0051093 8.71497751278498e-06 0.000114550255273979 1490 2107.18181818182 1976 8.71501169084851e-07 146 1.24959208943899 1.30350667351125 1 16.8264474110356 1488 1894 4516 2978 1814 2153 1976 1984 2536 146 1694 1860 M13269 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 17/18 Gene Ontology BP GO:0010801 0.190043612773654 0.233255850761227 1760 2275.72727272727 1977 0.01897894056769 988 0.825689924746942 0.815036299935771 1 1.77393992103598 1756 1143 3294 2889 4257 1263 1471 1977 988 3534 2461 1861 M14926 GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of keratinocyte differentiation. 36/44 Gene Ontology BP GO:0045616 0.11390439097611 0.149505537718432 3605 2287.72727272727 1977 0.0109334652490404 1285 1.52214946108322 1.06472942333007 1 4.28454368670168 3604 1625 1799 1331 2930 2549 1977 1689 1285 2005 4371 1862 M15304 GO_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 204/277 Gene Ontology BP GO:0048863 1.27857219321916e-13 1.69977040429964e-11 1725 1976 1977 1.16233835747203e-14 24 1.39730115786081 1.4422901150002 1 51.4389845371208 1721 1977 24 2261 4147 3408 2386 1574 2786 76 1376 1863 M11927 GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY.html Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 254/367 Gene Ontology BP GO:0050803 5.56355297776265e-07 1.05232569128169e-05 1655 2033.09090909091 1979 5.05777671338475e-08 187 1.35235723296965 1.19546964489945 1 23.0051139761085 1651 2953 187 2323 3030 972 1371 4196 1979 445 3257 1864 M14295 GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 26/34 Gene Ontology BP GO:0055094 0.000875992773149821 0.00361278190941396 3425 1881.72727272727 1980 7.96674335664289e-05 201 1.65543553690386 -1.77626444371685 -1 13.8115793177686 3425 1033 1072 1004 378 2181 2628 201 3699 1980 3098 1865 M15849 GO_DORSAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. 7/28 Gene Ontology BP GO:0021516 0.000423629424780434 0.00216371867563486 2135 1880.72727272727 1980 4.23710204304605e-05 49 1.03522199589929 0.800849139947463 1 9.42104638300845 2131 552 4576 363 284 3202 1287 3667 49 2597 1980 1866 M12277 GO_ALDITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 18/26 Gene Ontology BP GO:0019400 3.7547897826224e-05 0.000355102375173618 1985 1662.27272727273 1981 3.41350351636412e-06 87 0.980026309222056 -0.99762554002992 -1 11.5479239699032 1981 432 2030 952 87 1909 3195 2403 852 2131 2313 1867 M13361 GO_CELLULAR_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. 142/197 Gene Ontology BP GO:0044242 0.00241198693264886 0.00740790442086807 4400 2394.72727272727 1982 0.000219512309010222 270 1.09348737250482 -1.05019894969596 -1 7.95364257434007 4396 735 1938 270 555 2774 4437 3616 1982 1825 3814 1868 M14696 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. 12/33 Gene Ontology BP GO:0034723 0.233279084283701 0.279826650985321 1415 1838.18181818182 1982 0.0238591610555274 109 1.87179544838898 -2.15237120257433 -1 3.52900942802982 1414 1820 1982 1783 2644 1355 2058 2113 109 2584 2358 1869 M15799 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. 12/33 Gene Ontology BP GO:0006335 0.197124611035471 0.240636607631611 1415 1828.54545454545 1983 0.0197617400304352 110 1.87179544838898 -2.15237120257433 -1 3.94835648191286 1415 1821 1983 1784 2645 1356 2059 1995 110 2587 2359 1870 M16135 GO_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOCLAST_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. 44/50 Gene Ontology BP GO:0030316 0.193878832756733 0.237274647242788 1405 2270.36363636364 1983 0.0194021456210373 1373 1.02587562940711 1.09110840050621 1 2.18058997025605 1401 1579 1568 1373 3628 2588 2194 1983 4033 1868 2759 1871 M11659 GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 26/33 Gene Ontology BP GO:0046134 0.0442223156913353 0.0672695983754418 915 2587.09090909091 1984 0.00410337086939827 850 0.824993993851938 -0.824993993851938 -1 3.29560441620244 912 4474 3728 4015 4304 850 1295 1213 1984 3925 1758 1872 M13330 GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. 32/61 Gene Ontology BP GO:0006775 0.0066063920926418 0.0149076345330079 4155 2358.90909090909 1986 0.000602392206220237 725 1.63270924094464 -1.46801645798538 -1 10.1856381707641 4154 973 725 1986 2474 3423 4627 1229 795 994 4568 1873 M14292 GO_NEUTRAL_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. 71/116 Gene Ontology BP GO:0006638 4.54586538223953e-05 0.000417197467920326 2845 1597.36363636364 1989 4.13269028753136e-06 92 1.32567549479598 1.28076992244531 1 15.3073505939031 2845 92 309 254 2209 2474 2984 1989 373 244 3798 1874 M14932 GO_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_DEVELOPMENT.html The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. 188/268 Gene Ontology BP GO:0060485 3.2280178632954e-13 4.05945057240905e-11 935 1476.18181818182 1989 2.93456169390534e-14 25 1.41472842115624 1.51508270144679 1 50.2519552547666 935 1989 25 1994 3254 2794 2084 944 2038 88 93 1875 M16623 GO_COPULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPULATION.html The act of sexual union between male and female, involving the transfer of sperm. 11/20 Gene Ontology BP GO:0007620 0.000703547512083483 0.00309122433779457 1895 2044.90909090909 1989 6.3979327578801e-05 144 1.68586728176651 1.89129274247598 1 14.4559526724782 1891 2394 1330 3203 1339 2048 1989 144 3691 3106 1359 1876 M16462 GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT.html The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. 142/166 Gene Ontology BP GO:0030705 0.0467692523306324 0.0705469976529212 1990 1959.45454545455 1990 0.00434492220954936 652 0.982184227673137 -1.07408359579604 -1 3.85618801750598 1990 2030 3759 2108 2218 722 1885 1296 1290 3604 652 1877 M16654 GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 14/15 Gene Ontology BP GO:0060628 5.90501509876475e-05 0.00050693791982569 2100 2069.54545454545 1991 5.36833963736327e-06 103 0.635904941504683 0.743202291018127 1 7.15317921683923 2100 2859 3690 2675 103 1914 430 1231 1126 4646 1991 1878 M10497 GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH.html The activation of endogenous cellular processes that result in the death of a cell as part of its development. 31/41 Gene Ontology BP GO:0010623 0.156963552301998 0.197445636350688 2090 2039.36363636364 1993 0.0154024308824796 989 1.13626453850995 1.22706783848832 1 2.72640285813072 2086 989 2038 1690 4075 2393 1914 2878 1063 1993 1314 1879 M16742 GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus. 16/18 Gene Ontology BP GO:2001275 2.44787350793777e-06 3.77150842133591e-05 3645 2049.54545454545 1993 2.22534202874262e-07 10 0.949330254407216 -0.750153754083882 -1 14.3466873254255 3642 450 1993 639 10 3584 2240 3096 1272 1900 3719 1880 M15727 GO_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMPORT_INTO_CELL.html The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 35/59 Gene Ontology BP GO:0098657 0.00418219408532303 0.0111071627163288 3835 2235.72727272727 1996 0.000380924149873448 395 1.61531742015402 -1.74144157293726 -1 10.7828560331695 3834 1632 752 2766 1996 4609 3298 395 964 1214 3133 1881 M16815 GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. 48/91 Gene Ontology BP GO:0045671 0.00167846062292675 0.00580055755191795 745 2091.54545454545 1996 0.000152703868317971 233 1.44679107893667 1.36558518641995 1 11.0523399428238 745 3380 1845 3369 3785 2385 1864 233 1996 2121 1284 1882 M14467 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 38/39 Gene Ontology BP GO:1902229 0.0316347201792298 0.0512316754520936 2000 2241.90909090909 1997 0.00291808932183417 1135 1.2611915413635 1.48712849984562 1 5.55373927026484 1997 3753 2634 2835 1293 3057 1593 1381 1135 3514 1469 1883 M11070 GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. 36/46 Gene Ontology BP GO:0045747 0.0239517094585268 0.0411082622223534 1465 2114.09090909091 1998 0.00220150183953862 422 1.18875577701698 1.12564455058949 1 5.62273607073467 1463 3085 1900 3350 1998 1266 422 2243 4083 2392 1053 1884 M13017 GO_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 66/99 Gene Ontology BP GO:0043550 0.103620321828507 0.137755816419441 2000 1912.90909090909 1998 0.00989537067882496 110 1.08181550816532 -0.921079756183922 -1 3.17348574022376 1998 110 1272 666 3063 2356 2088 3597 1376 1171 3345 1885 M14154 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. 56/69 Gene Ontology BP GO:0060761 0.125837552644334 0.16296190716785 1775 2531.54545454545 1998 0.0121518403815177 1176 1.15308430267578 -1.16526436184299 -1 3.09555746463897 1773 3719 2301 3916 4116 1176 1437 1751 3997 1663 1998 1886 M15028 GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of B cell differentiation. 21/26 Gene Ontology BP GO:0045579 0.00577426225782821 0.0134540021460564 3625 1959.36363636364 1998 0.000526315789473684 118 1.31752336777849 -1.23813816572641 -1 8.41800630141114 3622 364 1998 118 2170 2312 4268 2174 890 1942 1695 1887 M10187 GO_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. 98/182 Gene Ontology BP GO:0006694 0.000385886610424838 0.00201424743264169 1255 1913.90909090909 1999 3.50867557019672e-05 267 1.09365375798853 -1.14400673573442 -1 10.0696493990356 1253 2066 1999 2287 267 1572 3462 312 3280 3344 1211 1888 M13264 GO_NEUTRAL_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. 14/30 Gene Ontology BP GO:0046461 0.0731387353008899 0.102628026343498 4115 2658.90909090909 1999 0.00688088890073666 498 1.48591402054953 1.34984056732469 1 5.01236499952541 4114 498 1185 1742 1941 4527 4088 3742 1999 1145 4267 1889 M14056 GO_BLASTODERM_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTODERM_SEGMENTATION.html The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. 20/27 Gene Ontology BP GO:0007350 0.016370435924846 0.0303351805489082 1185 2131.09090909091 1999 0.00149941221852743 875 1.57031569971383 1.30325621810023 1 8.13950304929305 1185 3159 875 3011 1063 1999 1361 3538 3276 1847 2128 1890 M16013 GO_CELLULAR_COMPONENT_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY.html A cellular process that results in the breakdown of a cellular component. 552/744 Gene Ontology BP GO:0022411 0.0787429644103365 0.109207455559254 2000 2355.27272727273 1999 0.0081680783272321 783 1.05566376199648 -1.01312937321991 -1 3.46053370682223 1999 1911 4586 1511 1999 783 2164 2855 2251 3975 1874 1891 M13476 GO_DETOXIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETOXIFICATION.html Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. 61/97 Gene Ontology BP GO:0098754 1.76617067167949e-05 0.000202913386057399 2840 2324.63636363636 2000 1.60562259158425e-06 45 1.22094752906267 -1.23467525727049 -1 15.4039346328793 2838 2125 1413 2000 45 4309 3199 1825 1787 1975 4055 1892 M14211 GO_ACYLGLYCEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 14/30 Gene Ontology BP GO:0046464 0.0731387353008899 0.102628026343498 4115 2659.45454545455 2000 0.00688088890073666 499 1.48591402054953 1.34984056732469 1 5.01236499952541 4115 499 1186 1743 1942 4528 4089 3737 2000 1147 4268 1893 M14395 GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. 9/11 Gene Ontology BP GO:0045741 3.50878058688926e-06 5.182970181205e-05 2690 1800.36363636364 2000 3.50878612709512e-07 15 1.54772960651009 -1.85841971554461 -1 22.6660986370149 2687 548 4490 584 15 2145 2864 2000 674 1469 2328 1894 M15071 GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. 17/23 Gene Ontology BP GO:0046321 0.0640249467979506 0.0917487149525297 1750 2298.45454545455 2000 0.00599707762128663 1135 0.998587727550633 1.17299930804361 1 3.53114423969048 1749 1135 1879 3060 4414 2000 1362 1391 4010 2042 2241 1895 M10981 GO_SUCKLING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUCKLING_BEHAVIOR.html Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. 12/21 Gene Ontology BP GO:0001967 0.000509474501277627 0.00244895129591405 4565 1794.81818181818 2001 4.63265930273979e-05 86 1.25355942692271 -1.38642045457998 -1 11.1797864084052 4564 489 2266 526 300 3763 2462 2001 86 2575 711 1896 M10306 GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING.html Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. 36/62 Gene Ontology BP GO:0010955 0.0376531710360835 0.0593496628830951 3120 2282.27272727273 2002 0.00348304410030291 950 1.25005471985156 -1.33522352142553 -1 5.23158978761293 3116 950 1027 975 2002 3079 3043 1861 3721 1291 4040 1897 M15271 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 15/17 Gene Ontology BP GO:0044252 0.0423244234547975 0.0651241872801497 185 1893.45454545455 2002 0.00392375505693611 181 1.25707287272498 1.25707287272498 1 5.08771383569381 181 2349 2002 3691 2134 1280 590 1348 3501 2917 835 1898 M16220 GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. 36/62 Gene Ontology BP GO:1903318 0.0376531710360835 0.0593496628830951 3120 2258.36363636364 2003 0.00348304410030291 951 1.25005471985156 -1.33522352142553 -1 5.23158978761293 3117 951 1028 976 2003 3080 3044 1588 3722 1292 4041 1899 M16228 GO_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 927/1233 Gene Ontology BP GO:0060284 2.66934098039073e-05 0.000280371186947134 1545 2159.90909090909 2003 2.66937304514852e-06 181 1.17641402220313 1.26258794725534 1 14.2769004529992 1545 1884 4606 1216 3565 2131 2328 2003 2545 181 1755 1900 M10228 GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 26/28 Gene Ontology BP GO:0022011 0.00647378784316122 0.0146653042036169 420 1767.09090909091 2005 0.000590265151101549 175 0.934189439189559 0.921254361355897 1 5.84610186299629 417 2741 2917 2457 2005 185 175 520 3353 3605 1063 1901 M10533 GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 41/84 Gene Ontology BP GO:0090207 0.0588247789389498 0.0854814792014158 3395 2150.63636363636 2006 0.00549628977311991 221 1.16167093888853 -1.09211770884719 -1 4.23161238351138 3392 221 2006 776 1513 4238 3129 2005 447 2383 3547 1902 M13926 GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. 139/188 Gene Ontology BP GO:0050852 0.00378528327617482 0.010384592062893 3040 2110.09090909091 2006 0.00034471017300736 387 0.846356423751791 -0.736386142593267 -1 5.72920814648065 3040 738 3545 387 653 1202 2943 2006 3196 3670 1831 1903 M13993 GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. 171/268 Gene Ontology BP GO:0048738 5.98147478647135e-05 0.000510675269384426 1105 2103.81818181818 2006 5.43785220010839e-06 321 1.2003521997468 1.28244210447515 1 13.4989167077555 1102 2006 321 2875 4441 3576 2755 1200 3313 922 631 1904 M14610 GO_REGULATION_OF_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROVILLUS_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. 24/32 Gene Ontology BP GO:0032530 0.0180089680285038 0.0327199251216823 3085 2247.45454545455 2006 0.00165073631368935 1013 1.29135351559852 -1.33867065471022 -1 6.54654450172671 3083 2759 1996 2006 1086 3659 3336 2095 1013 1783 1906 1905 M14616 GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT.html The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 26/28 Gene Ontology BP GO:0032292 0.00647378784316122 0.0146653042036169 420 1772.09090909091 2006 0.000590265151101549 176 0.934189439189559 0.921254361355897 1 5.84610186299629 418 2742 2918 2458 2006 186 176 562 3354 3609 1064 1906 M15050 GO_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 137/182 Gene Ontology BP GO:0032526 0.000469160885056916 0.00232364264403131 1775 2145.18181818182 2006 4.26600878016387e-05 446 1.169887113753 1.17315520887234 1 10.5240870101592 1775 1436 446 2198 596 3629 3576 2661 3849 1425 2006 1907 M15869 GO_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of sprouting angiogenesis. 36/46 Gene Ontology BP GO:1903670 0.0397285602913551 0.0619286402129565 3510 2515.27272727273 2006 0.00367860681324679 660 1.1946983797919 1.30555074947718 1 4.9239902267403 3506 957 1694 660 1367 3665 3768 4469 1734 2006 3842 1908 M13880 GO_RETINAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. 13/26 Gene Ontology BP GO:0042574 0.00117606155345567 0.0044388316373356 4580 2533.09090909091 2007 0.000106971883239572 420 1.89504552139637 -2.02444502190112 -1 15.2328268671853 4157 1826 554 2007 420 4455 4576 1243 3382 664 4580 1909 M12263 GO_PROXIMAL_DISTAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROXIMAL_DISTAL_PATTERN_FORMATION.html The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). 26/48 Gene Ontology BP GO:0009954 0.128909003188753 0.166107336426826 970 2184.90909090909 2008 0.0124678814316153 968 1.15925131096807 1.01213351158432 1 3.07926323181618 968 2743 1344 2363 3778 2008 1117 2557 3530 1977 1649 1910 M11157 GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. 160/206 Gene Ontology BP GO:1901136 0.0041736037226971 0.0110929214706609 460 2091.27272727273 2009 0.00038014022985153 459 1.21430410523983 -1.08027717800337 -1 8.10560634145141 3605 2009 696 459 2538 1335 3269 3824 1507 460 3302 1911 M12213 GO_RESPONSE_TO_GLUCAGON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GLUCAGON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 48/61 Gene Ontology BP GO:0033762 0.0395764022726108 0.0617742367576177 3545 2569.45454545455 2009 0.00366425600619994 733 1.35965710449488 -1.50831026944486 -1 5.61038531861735 3541 2650 1571 2009 4565 4193 4527 1352 1172 733 1951 1912 M11114 GO_MITOCHONDRIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSPORT.html Transport of substances into, out of or within a mitochondrion. 214/271 Gene Ontology BP GO:0006839 0.0943572298909522 0.127333001938109 730 2281.18181818182 2010 0.00896956258899615 729 0.797755141501498 -0.724978046330259 -1 2.43059539758067 729 1973 4026 2378 2314 956 1541 1575 3263 4328 2010 1913 M11446 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 41/63 Gene Ontology BP GO:0010719 0.00642586222161295 0.0146136544072165 2015 2043.72727272727 2010 0.000585882571708349 511 1.23001122803407 1.39273506414699 1 7.70715708376645 2013 2683 1825 2905 2826 1967 1850 511 2076 2010 1815 1914 M13654 GO_RECEPTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 85/123 Gene Ontology BP GO:0043112 0.00327740338087786 0.00935567971240779 2285 2088.63636363636 2010 0.000298390548215409 611 1.26252579742158 1.1650504543083 1 8.7472093402056 2283 808 2010 792 611 3041 3097 4116 900 1396 3921 1915 M14755 GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic hydroxy compound. 157/247 Gene Ontology BP GO:1901617 0.00260665493407463 0.0078656066201357 2220 1895.18181818182 2010 0.000237249867650912 465 1.21682617252712 -1.33930949802702 -1 8.74364812520991 3233 1416 610 465 1098 2487 4274 2217 2010 821 2216 1916 M12407 GO_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. 27/55 Gene Ontology BP GO:0050433 0.0794591135738272 0.110069441934807 2785 2134.54545454545 2011 0.00749845991302082 598 1.40612821431738 -1.31925978676455 -1 4.59650356977636 2781 1029 1532 2779 1642 3400 2011 1817 598 2076 3815 1917 M10413 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION.html The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. 8/21 Gene Ontology BP GO:0021843 0.0170548649177856 0.0313227439754325 1065 2192.18181818182 2014 0.00171871872284752 363 1.37256346867592 1.37256346867592 1 7.04784948414385 1064 3605 4238 3592 2522 1684 363 842 3201 2014 989 1918 M13235 GO_GLYOXYLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYOXYLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. 26/32 Gene Ontology BP GO:0046487 0.00688501145042892 0.0154019030186758 1790 2077.36363636364 2014 0.00062787757483552 533 0.871761260317445 -0.868685193380935 -1 5.39128246402103 1788 2249 3533 2833 2627 1443 2014 533 1239 3929 663 1919 M12766 GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION.html The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 162/271 Gene Ontology BP GO:0009952 0.011864860399042 0.0235425140455191 1400 2268.27272727273 2017 0.00108448512189815 812 1.19038686035515 1.12492479112272 1 6.61568461605177 1400 2968 812 2326 4241 1643 1906 4034 2059 1545 2017 1920 M15970 GO_RESPONSE_TO_COBALT_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COBALT_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. 17/17 Gene Ontology BP GO:0032025 0.000888400006632304 0.00364526034467382 4100 2301.27272727273 2017 8.07962692418528e-05 383 0.917869992851401 -0.961094100007705 -1 7.64099688051954 4096 452 2788 1393 383 4526 2017 1275 681 3079 4624 1921 M11767 GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 153/223 Gene Ontology BP GO:0043433 0.095746241384526 0.128982993967053 1390 2063 2018 0.00910783838953511 1309 1.01777962862039 1.10235610708697 1 3.08444861230647 1388 2018 2842 2324 1722 1309 1548 3351 1781 2049 2361 1922 M10801 GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. 31/45 Gene Ontology BP GO:0040020 0.0121278223556295 0.0239234260314387 2940 1916.81818181818 2019 0.00110865448418119 290 1.18768133904465 -1.23334279840706 -1 6.57231949941359 2937 290 2019 2591 1678 1810 3157 704 799 2771 2329 1923 M11503 GO_KIDNEY_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 142/192 Gene Ontology BP GO:0072073 5.46890650372495e-09 1.85743225998775e-07 1830 2069.90909090909 2019 4.97173319756355e-10 101 1.30869202886621 1.25877257301889 1 30.1065709663824 1826 2019 101 307 4325 2266 2102 4312 1613 159 3739 1924 M12613 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION.html The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. 8/21 Gene Ontology BP GO:0021826 0.0170548649177856 0.0313227439754325 1065 2206.81818181818 2019 0.00171871872284752 364 1.37256346867592 1.37256346867592 1 7.04784948414385 1065 3606 4377 3593 2523 1685 364 851 3202 2019 990 1925 M16262 GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of cation channel activity. 82/127 Gene Ontology BP GO:2001257 0.115606482948269 0.151297301363117 1795 2276.18181818182 2019 0.0111063333081937 1117 1.01274693996434 0.943634893204255 1 2.82919516998864 1795 2091 1638 3004 3234 2019 1945 3102 3390 1703 1117 1926 M10271 GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT.html The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. 24/31 Gene Ontology BP GO:0060973 0.00255341056455625 0.00775523456715421 2020 2360.72727272727 2020 0.000232398089315165 605 1.49911372725952 1.37818256446375 1 10.8059882723539 2020 3805 605 3484 1869 3253 2868 1905 3615 1350 1194 1927 M14919 GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. 22/23 Gene Ontology BP GO:0051497 0.0266746073190013 0.04489291783964 1745 1932.90909090909 2020 0.00245487554580561 852 1.10055102300939 1.17542490927698 1 5.06082282378872 1745 1066 2020 2280 1221 1093 852 3000 3510 2062 2413 1928 M13079 GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 87/98 Gene Ontology BP GO:0060998 0.125687269480154 0.162857940654736 2145 2211.72727272727 2021 0.0121364027112958 373 1.11795850108641 1.17546014245609 1 3.00199368151941 2142 802 1598 373 1836 2888 3597 4417 2021 1452 3203 1929 M10339 GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 294/477 Gene Ontology BP GO:0045861 0.000824059906646252 0.00346060536608755 1880 2176.90909090909 2023 7.49426126311172e-05 485 1.16729373241658 -1.11126746617033 -1 9.81037424313541 1876 1371 485 2053 856 2023 2407 3864 3757 1936 3318 1930 M11686 GO_REGULATION_OF_PROTEIN_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_GLYCOSYLATION.html Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. 14/16 Gene Ontology BP GO:0060049 0.00770300362066224 0.0168035986155374 2210 2305.63636363636 2023 0.000702737054986873 563 0.823108249138393 0.890812626306282 1 4.98334586019296 2206 3902 3530 3398 2023 1378 1228 563 1703 3847 1584 1931 M12147 GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. 20/22 Gene Ontology BP GO:0045540 0.027735347929176 0.0464050966970355 3835 2428.45454545455 2026 0.00255375504072633 98 1.2715249008267 -1.42861216561161 -1 5.78614524489818 3835 413 2026 863 1231 3881 4496 3714 98 1844 4312 1932 M15507 GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. 185/232 Gene Ontology BP GO:0030177 0.181010388862283 0.223287735783723 2035 2166.54545454545 2026 0.0179893053474493 707 1.12298588207253 1.23943354184753 1 2.48932478221422 2032 707 1464 887 2026 4219 2989 3117 1521 1622 3248 1933 M16662 GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. 8/12 Gene Ontology BP GO:0042487 0.000946052302528064 0.00380794235610993 750 2038.81818181818 2026 9.46455300743631e-05 185 1.84974660458984 1.84974660458984 1 15.2895021327638 748 3607 4642 2819 2964 1167 1345 185 2168 2026 756 1934 M10249 GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT.html The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. 147/195 Gene Ontology BP GO:0061008 0.0442213228301533 0.0672695983754418 905 2028.45454545455 2027 0.00410327682065054 608 1.18184368786925 1.0922409730099 1 4.72572442993978 905 2025 2524 2431 3457 1674 608 3214 1068 2027 2380 1935 M11004 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 14/18 Gene Ontology BP GO:0060261 0.0316770965561301 0.0512316754520936 2385 2226.27272727273 2028 0.00292205604053671 1120 1.17515176559093 -1.17515176559093 -1 5.17413007905317 2384 2362 3637 2459 1296 1686 2028 1659 1120 3845 2013 1936 M11817 GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 20/33 Gene Ontology BP GO:0061217 0.0263868064179308 0.044533119427868 2030 2231.27272727273 2028 0.00242806438625549 471 1.17452769556814 1.43822751241703 1 5.4157507259973 2028 3505 1968 3560 2630 3006 1602 970 1981 2823 471 1937 M12654 GO_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. 141/246 Gene Ontology BP GO:0048469 0.0101961435187515 0.0209830410405798 1245 1889 2028 0.000931246143580132 174 1.09460567666048 0.999053260500831 1 6.26957552780666 1241 2028 1463 3252 3246 174 845 2106 2343 1984 2097 1938 M10673 GO_ENERGY_RESERVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_RESERVE_METABOLIC_PROCESS.html The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. 67/89 Gene Ontology BP GO:0006112 0.200306102861383 0.243985417961784 1250 2106.81818181818 2029 0.0201154971178124 820 0.946991191193791 0.940886625861399 1 1.97287725489746 1249 1519 2924 820 2842 2190 1750 3648 2736 2029 1468 1939 M12775 GO_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 105/118 Gene Ontology BP GO:0038127 0.00577426225782821 0.0134540021460564 2030 2036.09090909091 2029 0.000526315789473684 236 1.09860908253379 1.15782032137273 1 7.01753318408508 2029 788 2308 236 3948 2011 2312 2997 1044 1009 3715 1940 M13818 GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. 20/21 Gene Ontology BP GO:0031293 0.159558256887364 0.200222375754289 2970 2155.54545454545 2029 0.0156783081959613 1093 0.975634699884111 0.82070411032007 1 2.31924232615333 2966 1093 3194 1104 3484 1409 1835 2029 2917 2357 1323 1941 M14978 GO_REGULATION_OF_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUTAMATE_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of glutamate. 10/26 Gene Ontology BP GO:0014048 5.45807546633058e-05 0.000481297359748292 2055 1776.63636363636 2030 4.9620098934516e-06 18 2.22071051864148 2.29016277455139 1 25.1780877486057 2053 3591 1317 2103 2453 2030 3169 18 1111 1651 47 1942 M11437 GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. 27/44 Gene Ontology BP GO:0045920 0.0193787443262889 0.0346938427665342 2035 1908.81818181818 2031 0.00177741614060823 334 1.0033317569273 0.999078029588433 1 4.99676561058324 2031 1015 2992 1390 3169 1519 370 2689 334 2501 2987 1943 M12167 GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 135/200 Gene Ontology BP GO:0002221 0.196324434314867 0.23976314773414 1975 2270.09090909091 2032 0.0196729671997259 1270 1.16702432305095 1.04914966066065 1 2.46400210702298 1975 2032 1653 1270 3495 2283 1407 3177 1597 2180 3902 1944 M10295 GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 17/24 Gene Ontology BP GO:0009084 0.17574145170449 0.217422221425416 3785 2205.27272727273 2033 0.0174166392398601 367 1.15407911308115 -1.32479589255259 -1 2.60416085099714 3781 433 1763 745 2017 3445 3825 2421 367 2033 3428 1945 M16551 GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 46/71 Gene Ontology BP GO:0006636 4.61161898359668e-06 6.54203144227907e-05 240 1788.36363636364 2033 4.19238968223337e-07 150 1.71517706152383 -1.80026624419037 -1 24.5264173607061 3273 2154 240 936 238 2886 1603 2033 2259 150 3900 1946 M16726 GO_PHAGOCYTOSIS_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_RECOGNITION.html The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. 14/130 Gene Ontology BP GO:0006910 0.0476179334897016 0.0715650414507961 1460 2066.90909090909 2033 0.00442554142458739 827 1.20577222118881 1.2389528709601 1 4.71080036850993 1457 2864 1084 3466 2033 2184 827 2166 4030 1641 984 1947 M10592 GO_MYELOID_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. 51/60 Gene Ontology BP GO:0061515 0.0721285203860485 0.101639613978281 4015 2522.45454545455 2034 0.00678253476327873 855 1.06258657133462 -1.27286707105792 -1 3.59660544603471 4014 886 2034 1029 4434 4436 4155 3220 1319 1365 855 1948 M10601 GO_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 137/177 Gene Ontology BP GO:0010921 0.270397072780067 0.319329334935444 1785 2389.63636363636 2034 0.0282527408959412 1538 0.978441411148909 1.02175189690532 1 1.64777725634572 1782 2034 3485 1682 4139 1538 1616 2476 2068 3512 1954 1949 M10608 GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-10 production. 31/70 Gene Ontology BP GO:0032653 0.0400497767588244 0.0622624828796559 2035 2318.09090909091 2034 0.00370890918365526 1043 1.48216567682251 1.3881953857676 1 6.09953024442716 2034 3429 1043 3227 4322 2658 1794 1804 1060 1243 2885 1950 M16931 GO_PROTEIN_HETEROOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 122/185 Gene Ontology BP GO:0051291 0.046788745918099 0.0705469976529212 1545 1928.54545454545 2034 0.0043467732418328 1079 1.19992455733883 1.03004809741351 1 4.7134297998995 1542 2046 1079 2124 1723 2034 1473 1840 2120 2087 3146 1951 M16144 GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 138/173 Gene Ontology BP GO:0010811 1.26898507743192e-05 0.000154976051582434 890 1926.54545454545 2036 1.15362945194692e-06 264 1.31962350824659 1.22341584542611 1 17.177809414519 890 2036 264 2195 2093 1718 1539 3952 3471 401 2633 1952 M10942 GO_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. 39/56 Gene Ontology BP GO:0046632 0.00627656173999464 0.0143583292901647 2515 2321.72727272727 2037 0.000572230955724719 503 1.28017928756768 1.33815333626886 1 8.0554458098479 2511 3404 1746 3061 1860 2037 1773 503 3175 1861 3608 1953 M12038 GO_SPECIFICATION_OF_SYMMETRY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_SYMMETRY.html The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. 132/206 Gene Ontology BP GO:0009799 0.0617494514245048 0.0890363177806696 4355 2573.18181818182 2037 0.00577763185270101 1107 1.24855719827589 -1.29708832042644 -1 4.47337374953337 4354 2037 1140 1999 4553 1226 3437 3651 1406 1107 3395 1954 M14400 GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein homooligomerization. 18/19 Gene Ontology BP GO:0032462 0.00375933046779395 0.0103259531680314 1420 2146.27272727273 2038 0.000342342706478335 118 1.02478376641233 1.15455891864764 1 6.94789399607292 1420 3854 2759 3272 2159 1006 118 2004 1830 3149 2038 1955 M11859 GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 28/35 Gene Ontology BP GO:0090200 0.00963255449673062 0.0200453716193938 1420 2557 2039 0.000879544577462688 165 0.643349671962503 -0.661996262813426 -1 3.72419081503592 1416 4470 3537 4431 2039 165 1030 1285 4610 4490 654 1956 M13778 GO_ADRENAL_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENAL_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. 17/28 Gene Ontology BP GO:0030325 0.00100381605792158 0.00398528678968355 4540 2469.90909090909 2039 9.12976701757264e-05 335 1.09945300470498 -1.18236865337935 -1 9.0091424474094 4536 1740 1844 806 401 3526 3805 3861 335 2039 4276 1957 M16002 GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rho protein signal transduction. 131/144 Gene Ontology BP GO:0035023 0.0347720466686688 0.0555231067773905 945 1791.72727272727 2039 0.00321219206097255 611 1.12657516849383 1.1127640765607 1 4.82524922043569 945 2039 1012 2288 2182 611 1026 2191 3670 1580 2165 1958 M11955 GO_REPLACEMENT_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLACEMENT_OSSIFICATION.html Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. 42/52 Gene Ontology BP GO:0036075 0.00162643024256022 0.00567299843975466 685 1820.27272727273 2040 0.000147966716945116 544 1.29187034348036 1.18026164732038 1 9.91037998581399 682 2174 544 1137 984 2434 2040 2340 3668 1696 2324 1959 M13524 GO_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of T cell proliferation. 131/232 Gene Ontology BP GO:0042129 0.0615034807554051 0.0887641736832816 2260 2050 2040 0.00575393975069884 791 1.14032761655306 -1.17670425507148 -1 4.08986404547377 2260 2040 1339 1036 2708 1240 3369 2880 3843 1044 791 1960 M13546 GO_KERATAN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 12/15 Gene Ontology BP GO:0042340 0.00363805666655302 0.0100881273357993 2350 2034.18181818182 2041 0.000331280613462505 364 1.15117180590382 1.42815047009947 1 7.84593135751993 2350 1841 1949 2041 1266 2612 2355 364 3730 3198 670 1961 M15454 GO_ENDOCHONDRAL_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_OSSIFICATION.html Replacement ossification wherein bone tissue replaces cartilage. 42/52 Gene Ontology BP GO:0001958 0.00162643024256022 0.00567299843975466 685 1822.36363636364 2041 0.000147966716945116 545 1.29187034348036 1.18026164732038 1 9.91037998581399 683 2175 545 1138 985 2435 2041 2353 3669 1697 2325 1962 M11019 GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein oligomerization. 33/43 Gene Ontology BP GO:0032459 0.00373652112622523 0.0102754330971194 2945 2169.27272727273 2042 0.000340262039503148 650 1.22189299157857 -0.754174142324676 -1 8.29521684636305 2942 3424 1760 2796 650 2995 1131 1836 2042 3295 991 1963 M13351 GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY.html A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. 10/24 Gene Ontology BP GO:0007597 2.57549832215159e-05 0.00027235894756753 2955 2010 2042 2.34138952137882e-06 64 2.04867636822624 -2.6309859058707 -1 24.9587341707002 2952 2904 1385 2514 64 2066 2042 3933 1205 1649 1396 1964 M13612 GO_MEIOTIC_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEPARATION.html The process in which chromosomes are physically detached from each other during meiosis. 9/12 Gene Ontology BP GO:0051307 0.00367651533187832 0.0101592463568013 2000 2234 2043 0.000368261207694059 125 1.0729046260221 -1.0729046260221 -1 7.30057683111093 2000 2415 4438 2622 4275 1098 125 1419 585 3554 2043 1965 M15091 GO_PROTEIN_LOCALIZATION_TO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_SYNAPSE.html Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 17/20 Gene Ontology BP GO:0035418 0.00965431147294881 0.0200689554392296 3680 2325 2043 0.000881539985343186 627 1.85707459241076 -2.41891485765049 -1 10.7670154349639 3679 3538 954 1529 1250 2711 4571 627 2718 2043 1955 1966 M13480 GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. 36/47 Gene Ontology BP GO:0000038 0.00294038944152527 0.00861764758525369 4085 2322.63636363636 2044 0.000267666069170077 122 1.00581807738823 -0.854541081059448 -1 7.08920318765037 4083 1617 2395 122 584 4474 4386 831 2044 2002 3011 1967 M10567 GO_RESPONSE_TO_AMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. 51/77 Gene Ontology BP GO:0014075 0.190549792884641 0.233812334103674 3910 2072.45454545455 2045 0.0190346915453516 313 1.28617645151306 -1.24361921018623 -1 2.76466050243013 3910 885 1693 596 2045 3472 3756 2413 313 1364 2350 1968 M10429 GO_SINGLE_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BEHAVIOR.html The specific behavior of a single organism in response to external or internal stimuli. 395/632 Gene Ontology BP GO:0044708 1.70244168140748e-07 3.77212435408999e-06 1800 1788.27272727273 2046 1.54767437558977e-08 159 1.31320042026655 1.2741719285247 1 24.3391815152529 1796 2472 159 770 2499 1170 2046 3965 2071 462 2261 1969 M10933 GO_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. 125/161 Gene Ontology BP GO:0010469 0.0160153177505029 0.029783882291403 1205 2333.09090909091 2046 0.0014666460465249 869 1.12066145549953 -1.12157491953377 -1 5.83625125491534 4189 1442 869 2046 1201 2639 4471 2992 3485 1205 1125 1970 M14305 GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. 15/27 Gene Ontology BP GO:0035883 0.000519328089382448 0.00247839343579131 2050 1666.18181818182 2046 4.72227928706983e-05 93 1.10219626512135 1.1077551306568 1 9.80901849621354 2046 464 2131 831 306 2874 1386 3109 93 2372 2716 1971 M11815 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. 123/161 Gene Ontology BP GO:0097202 0.0796024747473167 0.1102352127974 1470 2183.90909090909 2047 0.00751251254633184 1258 1.14139953691354 1.34005339680005 1 3.72657194410412 1470 2047 1258 2862 3427 2837 1838 1492 2696 2547 1549 1972 M12592 GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 21/30 Gene Ontology BP GO:0034381 0.016601008456742 0.0306647448786108 2050 1932.36363636364 2047 0.00152069252671663 561 1.4653564355679 1.36052483869374 1 7.5712385991875 2047 2292 1296 1377 1061 3230 2918 2181 561 1092 3201 1973 M15938 GO_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORT.html The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 55/104 Gene Ontology BP GO:0015908 0.00109914084796163 0.0042266961698888 3640 1900 2047 9.99718521410005e-05 156 1.20476911745238 -1.25550977914935 -1 9.76793924762285 3639 156 567 298 412 2925 2047 3422 2506 684 4244 1974 M11719 GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 50/83 Gene Ontology BP GO:0030811 0.0823403292522767 0.113519867262472 1970 1945.45454545455 2048 0.0077812667141373 867 1.04762439296312 1.06712544886019 1 3.37385500249012 1970 2146 2610 1941 2121 2203 1722 1506 867 2266 2048 1975 M12089 GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM.html The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 23/25 Gene Ontology BP GO:0003159 0.00577426225782821 0.0134540021460564 2655 2225.18181818182 2048 0.000526315789473684 226 1.25104921770183 1.23768945698746 1 7.99274734640323 2653 1695 2539 226 2048 4599 4293 2025 294 1676 2429 1976 M12185 GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. 20/33 Gene Ontology BP GO:1903409 0.00577426225782821 0.0134540021460564 2500 2148.72727272727 2048 0.000526315789473684 137 1.25583032687543 1.23501097656486 1 8.02333381480636 2498 1713 1036 137 4485 3792 3553 685 2048 984 2705 1977 M11395 GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of intracellular signal transduction. 1666/2243 Gene Ontology BP GO:1902531 0.000181563948198457 0.0011652648978861 1505 2069.45454545455 2051 1.81578784364782e-05 254 1.1017094796069 1.14343799822008 1 11.0391965824354 1502 1256 4296 1178 2941 1586 2051 2608 2619 254 2473 1978 M14016 GO_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MATURATION.html Any process that modulates the frequency, rate or extent of protein maturation. 81/138 Gene Ontology BP GO:1903317 0.000516880307585382 0.00247687339978865 2480 2050.45454545455 2051 4.70001623905072e-05 452 1.31133994180422 1.49954047716795 1 11.6735148152257 2480 820 452 948 2356 3831 3305 2051 3580 683 2049 1979 M16529 GO_POST_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. 115/154 Gene Ontology BP GO:0009791 0.0421272454654057 0.0649091632348636 1885 2259.81818181818 2051 0.00390511276611623 1240 1.1728120870596 1.21829201570372 1 4.75173221028572 1884 3314 2012 3495 1392 1923 2190 1240 2588 2051 2769 1980 M11586 GO_ACETYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. 22/26 Gene Ontology BP GO:0006084 6.02580854948133e-05 0.000512371815338061 1950 2190.18181818182 2052 5.47815782085532e-06 105 0.835412040911327 0.870214605432796 1 9.387518009499 1950 1717 3069 3080 105 1747 2052 567 4452 2983 2370 1981 M15600 GO_LOCALIZATION_WITHIN_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_WITHIN_MEMBRANE.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. 164/194 Gene Ontology BP GO:0051668 0.0035323379316627 0.00989522480194252 3580 2481.81818181818 2052 0.000321638387625636 560 1.16521149372431 -1.110200541705 -1 7.97515405429461 3578 1409 1420 560 635 3832 4184 3507 2052 1830 4293 1982 M16536 GO_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 111/235 Gene Ontology BP GO:0042445 1.42920761507111e-05 0.000171837287672503 4260 2306.63636363636 2052 1.29928809077946e-06 267 1.51888300955202 -1.54651168913569 -1 19.5403013562717 4259 2052 267 1444 594 3942 4630 3131 1825 539 2690 1983 M10485 GO_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLERANCE_INDUCTION.html A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. 8/14 Gene Ontology BP GO:0002507 8.14098154694593e-05 0.000636638439293099 3025 2274 2053 8.14127980243641e-06 133 1.397341798584 1.62988345334017 1 15.2585412448092 3023 540 4244 184 133 4617 4097 4263 554 1306 2053 1984 M10978 GO_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 99/130 Gene Ontology BP GO:0009408 0.0533139714601788 0.0787523521283213 2410 2457.09090909091 2053 0.0049683244814969 718 1.23662158895532 -1.28580641412155 -1 4.65587339075585 2407 4334 1817 4197 3769 751 1350 1807 3825 2053 718 1985 M16386 GO_SIGNAL_PEPTIDE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_PEPTIDE_PROCESSING.html The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. 25/30 Gene Ontology BP GO:0006465 0.192475632969375 0.235805455557268 4045 2317.72727272727 2053 0.0192470948032524 242 1.58335246321953 -1.2733186298283 -1 3.38595347964486 4045 2258 1538 2305 2053 1742 1858 4046 242 1886 3522 1986 M14717 GO_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEPHOSPHORYLATION.html The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. 259/325 Gene Ontology BP GO:0016311 0.00577426225782821 0.0134540021460564 3345 2209.36363636364 2054 0.000526315789473684 45 1.02978284243771 -1.0163785405092 -1 6.57722706649461 3343 1375 2911 45 2054 920 3429 3433 1937 3181 1675 1987 M10162 GO_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCRETION.html The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. 34/63 Gene Ontology BP GO:0007588 0.284533844916942 0.334749931832751 2055 2144.09090909091 2055 0.0299796916242183 617 1.30928723381438 1.27684631613355 1 2.11687090075998 2055 1634 1665 1983 2252 2825 1651 3975 617 2230 2698 1988 M15129 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 4/21 Gene Ontology BP GO:0033139 0.000309799122725669 0.00174304149702846 1165 1935.09090909091 2055 3.09842320174912e-05 116 2.86475219453365 2.86475219453365 1 27.0091749744315 1162 2431 4536 2070 245 2161 2055 4187 116 1991 332 1989 M15888 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 4/21 Gene Ontology BP GO:0033141 0.000309799122725669 0.00174304149702846 1165 1939.45454545455 2056 3.09842320174912e-05 117 2.86475219453365 2.86475219453365 1 27.0091749744315 1163 2432 4579 2071 246 2162 2056 4183 117 1992 333 1990 M16600 GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 78/125 Gene Ontology BP GO:0043266 0.000423066557441457 0.00216321834261 4070 2339.72727272727 2056 3.84679942101337e-05 438 1.19313299937492 -1.28545250799072 -1 10.8601529668577 4066 1500 438 1003 2056 4614 3389 1469 2681 1065 3456 1991 M14009 GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. 27/32 Gene Ontology BP GO:0072498 0.00206598590002513 0.00666183811006025 30 2240.90909090909 2057 0.000187993508175571 26 1.15353851352556 1.15353851352556 1 8.57283734364411 26 3816 1386 3684 2057 1169 1594 2083 4510 3342 983 1992 M12752 GO_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. 109/141 Gene Ontology BP GO:0060070 0.194405694349767 0.237731851723907 2075 2073.09090909091 2059 0.0194604261552354 621 1.17233225309631 -1.23066271348784 -1 2.49006784622816 2075 775 1686 621 2059 2171 2184 4639 965 1532 4097 1993 M12681 GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/33 Gene Ontology BP GO:0051953 0.000158818138296735 0.00105267919871041 3930 2344 2060 1.44390549588172e-05 177 1.42252097261323 -1.53802256087129 -1 14.4714729860384 3930 1831 1207 2060 177 3226 2692 2910 1635 1956 4160 1994 M13359 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. 156/215 Gene Ontology BP GO:0051092 0.322670939778298 0.375065671443523 3650 2427.54545454545 2060 0.034798128401303 1262 1.10608043425228 1.12969172293928 1 1.59990615496721 1262 3646 1928 3359 2809 2060 1782 2285 3650 1934 1988 1995 M15157 GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that activates or increases the frequency, rate, or extent of peptide secretion. 81/128 Gene Ontology BP GO:0002793 0.0808086785502104 0.111639780669278 1710 2473.72727272727 2061 0.00763082663181816 1211 1.33104767373914 1.35418509269686 1 4.32250549495533 1708 3682 1211 3505 3757 2882 2061 1495 3927 1421 1562 1996 M12483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. 28/34 Gene Ontology BP GO:0014912 0.104795945252408 0.139040642503409 2895 2341.90909090909 2062 0.010013490743748 860 1.44308348238811 1.55100410922307 1 4.21692711915934 2895 1666 1276 860 3015 4199 3712 4193 881 1002 2062 1997 M16247 GO_LIMBIC_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMBIC_SYSTEM_DEVELOPMENT.html The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. 112/180 Gene Ontology BP GO:0021761 0.0227464339496672 0.0393866077063887 2520 2372.72727272727 2062 0.00208955249826125 928 1.23057100548762 1.27411288724412 1 5.89906751907567 2517 1455 928 1909 2062 3463 1955 4059 2431 1270 4051 1998 M10367 GO_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_SECRETION.html The controlled release of acid by a cell or a tissue. 64/113 Gene Ontology BP GO:0046717 0.00663379111386989 0.0149392825714644 2065 2185 2063 0.000604898112086923 671 1.26875185346448 1.1528306196276 1 7.90872209021819 2063 3024 727 3211 3788 857 671 3303 3129 1538 1724 1999 M10717 GO_NEGATIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. 32/49 Gene Ontology BP GO:0014014 0.176907967222936 0.218690959481488 2055 2334.90909090909 2063 0.0175431371407114 898 1.49564201524685 1.24686193503149 1 3.36512640960722 2052 4093 2063 2963 2019 1323 1517 4010 898 2489 2257 2000 M11822 GO_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_PROLIFERATION.html The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 69/97 Gene Ontology BP GO:0072089 0.121502326976175 0.15818419905432 1950 2506.63636363636 2063 0.0117074751642771 1140 1.3045535242781 -1.28412423048466 -1 3.56122988967877 1949 3700 1323 4164 3588 1467 1512 4543 2063 2124 1140 2001 M13050 GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 79/104 Gene Ontology BP GO:0010517 4.77933980399528e-09 1.69757771816718e-07 3370 1957.63636363636 2063 4.34485437670732e-10 75 1.39779276317787 1.35035064928622 1 32.3438452566046 3367 75 96 780 2995 3208 2063 2798 1929 197 4026 2002 M10285 GO_AMMONIUM_ION_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_METABOLIC_PROCESS.html The chemical reactions and pathways involving the ammonium ion. 145/208 Gene Ontology BP GO:0097164 6.3363114965006e-05 0.000535184630576114 4245 1948.90909090909 2064 5.7604490896383e-06 25 1.32364583519428 -1.41603896816508 -1 14.7944137964685 4241 736 403 25 2321 2567 4116 3682 1078 205 2064 2003 M11560 GO_SULFATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATION.html The addition of a sulfate group to a molecule. 9/26 Gene Ontology BP GO:0051923 0.00208588099546373 0.0067027653811414 2665 2173.18181818182 2064 0.000208784149067455 277 1.24490634035658 1.07788958866983 1 9.24138549250877 2663 2400 4311 1987 544 3410 994 2064 277 1465 3790 2004 M15075 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 110/162 Gene Ontology BP GO:0050806 0.000509127121778582 0.00244895129591405 3805 1940.45454545455 2064 4.62949984442852e-05 149 1.364360734571 -1.44124113004892 -1 12.1689029766426 3802 2054 451 149 910 2769 2484 3446 2064 376 2840 2005 M11565 GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 59/95 Gene Ontology BP GO:0051196 0.000696518900300509 0.00307778009790909 2070 1844 2066 6.33399559661597e-05 340 1.08028536721385 1.20063345154388 1 9.26637808422038 2066 2129 2740 1921 340 3263 2445 1043 646 2464 1227 2006 M15495 GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. 32/33 Gene Ontology BP GO:0033627 0.0064549335583069 0.0146439813977582 45 2139 2066 0.00058854098985759 43 1.33324308929354 1.33324308929354 1 8.35079100591931 43 3440 908 3191 1395 1808 2211 2066 4392 2492 1583 2007 M15443 GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 59/95 Gene Ontology BP GO:0051193 0.000696518900300509 0.00307778009790909 2070 1864 2067 6.33399559661597e-05 341 1.08028536721385 1.20063345154388 1 9.26637808422038 2067 2130 2741 1922 341 3264 2446 1253 647 2465 1228 2008 M13060 GO_SUBSTANTIA_NIGRA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTANTIA_NIGRA_DEVELOPMENT.html The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). 78/111 Gene Ontology BP GO:0021762 0.00265702194916299 0.00796669049194608 2070 1869.90909090909 2068 0.000241839669991331 46 1.00920054118938 -1.07913289652945 -1 7.23077528687828 2068 3010 3004 2578 664 46 1394 1371 3042 2815 577 2009 M13065 GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT.html Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. 19/19 Gene Ontology BP GO:2000641 0.00958593363492418 0.0200270475881494 2250 1964.72727272727 2068 0.000875268950432155 57 0.896404521960981 -0.519254111103661 -1 5.19447357969475 2249 3169 3634 1164 1046 2583 2068 618 57 4026 998 2010 M14637 GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 22/25 Gene Ontology BP GO:0046386 0.00792511392320842 0.0172074452098408 920 1770.36363636364 2068 0.00072307341539943 764 1.0589345097751 -1.00091462674918 -1 6.37682261228365 920 2279 3224 2523 848 910 814 2068 764 2986 2138 2011 M10316 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 62/84 Gene Ontology BP GO:0010518 8.13371000437697e-08 2.04573798110087e-06 3450 1940.45454545455 2069 7.39428209553793e-09 116 1.46060671831335 1.43983185292684 1 28.3994590027144 3448 116 139 549 2582 2850 2069 3155 1961 274 4202 2012 M14622 GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of guanylate cyclase activity. 7/14 Gene Ontology BP GO:0031282 0.00525070999993344 0.0130510436056038 3245 2345.36363636364 2069 0.000526315789473684 142 2.00598736755255 -1.84668303964631 -1 12.9129304763777 3245 1863 4505 142 1676 2069 3917 2257 3014 1809 1302 2013 M15372 GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle phase transition. 376/442 Gene Ontology BP GO:1901987 0.305865821727074 0.358036143017881 2070 2467.63636363636 2069 0.032645254985199 628 0.92989347191004 -0.85663162180668 -1 1.4075183178127 2069 628 4030 1396 4374 1542 2887 2770 1283 4181 1984 2014 M10393 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM.html A process in which an organism has a negative effect on the functioning of the second organism's cells. 10/82 Gene Ontology BP GO:0044364 0.00577426225782821 0.0134540021460564 1455 1686.36363636364 2070 0.000526315789473684 79 1.46420018266592 1.63332482213774 1 9.356350438959 1453 529 1563 94 2500 2807 2900 2245 79 2310 2070 2015 M16307 GO_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS.html An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. 190/443 Gene Ontology BP GO:0006909 0.000140181404643269 0.000973528471350944 370 1897 2070 1.27445761485354e-05 98 1.19422682269361 1.19990894695587 1 12.2859056845399 2070 697 369 98 3585 4019 2550 2695 1783 366 2635 2016 M11320 GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM.html Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 10/82 Gene Ontology BP GO:0031640 0.00577426225782821 0.0134540021460564 1455 1686.90909090909 2071 0.000526315789473684 80 1.46420018266592 1.63332482213774 1 9.356350438959 1454 530 1564 95 2501 2808 2901 2238 80 2314 2071 2017 M16921 GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 410/508 Gene Ontology BP GO:0031346 0.00265727565946708 0.00796669049194608 1645 1927.81818181818 2071 0.000241862790420656 412 1.17759917549574 1.22774156779121 1 8.43910626154512 1644 1927 956 1580 3263 2071 2376 2683 2124 412 2170 2018 M16343 GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 34/55 Gene Ontology BP GO:0010862 0.00412865041916 0.0110329917313101 1020 1879.72727272727 2072 0.000376038082481254 645 1.48962059789712 1.39507447498253 1 9.95777200692743 2726 2199 1016 1017 675 3911 2633 2072 967 645 2816 2019 M16796 GO_SPLEEN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLEEN_DEVELOPMENT.html The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. 37/48 Gene Ontology BP GO:0048536 0.000104506840182544 0.000773084781191379 3300 1892.72727272727 2072 9.50107317386926e-06 140 0.995476357555394 0.953155778901587 1 10.5801980125771 3300 243 2636 816 140 3362 2072 1937 220 2438 3656 2020 M11957 GO_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING.html The series of events that restore integrity to a damaged tissue, following an injury. 476/666 Gene Ontology BP GO:0042060 5.07315060989034e-09 1.77822879935182e-07 1345 1751.72727272727 2073 4.61195511053537e-10 97 1.24168795105962 1.2021655563458 1 28.6449336743639 1345 1339 97 2754 2195 2073 2246 2524 2023 155 2518 2021 M13358 GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. 1798/2297 Gene Ontology BP GO:0006796 0.0616434901494486 0.0889386541598092 3350 2340.63636363636 2073 0.00634233471982702 249 1.01417653403293 -0.955594810574516 -1 3.63327770892527 3349 564 4423 249 3767 679 2890 3944 1866 2073 1943 2022 M16053 GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION.html The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. 84/99 Gene Ontology BP GO:0035335 0.00577426225782821 0.0134540021460564 3675 2304 2073 0.000526315789473684 77 1.15686553310201 -1.12594868223093 -1 7.3902205710248 3673 77 2073 104 3087 2895 4558 1955 3479 1826 1617 2023 M16446 GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT.html The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. 42/58 Gene Ontology BP GO:0031076 0.00126031702033971 0.00470119153885569 1285 2258 2075 0.000114639963588247 431 1.2546670865003 -1.22733476192154 -1 9.97472891568932 2989 916 1283 1245 431 4242 3253 3356 1282 2075 3766 2024 M12759 GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of female gonad development. 6/17 Gene Ontology BP GO:2000194 0.0202209714504449 0.0358841266815104 2660 2204.18181818182 2076 0.00204073624190744 757 1.57601958774869 1.86101757281501 1 7.77599728662608 2660 2424 4387 2076 1162 757 1132 1814 3682 1573 2579 2025 M10666 GO_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COAGULATION.html Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. 93/144 Gene Ontology BP GO:0050818 1.13452434198752e-13 1.5996793222024e-11 2965 2008.09090909091 2078 1.03138576544325e-14 23 1.68159153867969 1.3291173995387 1 62.0582991061223 1571 2078 23 2480 3157 2963 1844 1393 3514 104 2962 2026 M13039 GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. 123/171 Gene Ontology BP GO:0071774 0.0774672467075284 0.107727166446542 525 2147.90909090909 2079 0.00730341754639602 525 1.18791257240371 1.15218282264802 1 3.91946178353068 525 3992 1728 4445 2293 741 935 2079 3339 2548 1002 2027 M14213 GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 90/160 Gene Ontology BP GO:0042035 0.00140865336924717 0.00509282371958594 915 1771.27272727273 2079 0.000128141466828284 535 1.17767258649539 1.16633216832167 1 9.22204036772895 911 2084 535 2786 1234 2163 1500 2239 3134 819 2079 2028 M13295 GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 45/69 Gene Ontology BP GO:0060393 0.0210740404699822 0.0369877146334738 2295 2030.09090909091 2080 0.0019344236755764 1014 1.50769096830445 1.43705575400718 1 7.37059431358204 2293 2665 1268 2080 1150 3297 2834 1648 1778 1014 2304 2029 M14410 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 24/50 Gene Ontology BP GO:0045078 0.0030429397670196 0.00886032461573354 1610 2186.09090909091 2080 0.000277014253713049 332 1.08244205563921 1.12498040270072 1 7.5854411761651 1608 3484 2080 3373 652 2784 1472 332 3892 2690 1680 2030 M14991 GO_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 177/261 Gene Ontology BP GO:0050920 1.30644685537137e-12 1.24059126898836e-10 1745 2126.54545454545 2080 1.18767895942922e-13 32 1.41657229578541 1.5414942013545 1 47.9677373522324 1742 2001 32 1965 4340 2718 2644 3434 2080 127 2309 2031 M10989 GO_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 816/1046 Gene Ontology BP GO:0043549 0.00449880865651766 0.0116618143057252 2095 2135.81818181818 2081 0.000450794236715665 476 1.15892129520078 1.19072587630328 1 7.64937231944832 2095 1891 4272 2081 2415 1212 2075 2039 2516 476 2422 2032 M12960 GO_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 37/45 Gene Ontology BP GO:0036314 0.0434294704086928 0.0664764516255192 4065 2313.81818181818 2081 0.00402829688971197 543 1.25232241625745 -1.05372702923169 -1 5.03023146438647 4063 943 1133 543 1403 2619 4611 2100 1983 2081 3973 2033 M10335 GO_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMMONIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. 53/89 Gene Ontology BP GO:0060359 0.0984357559850036 0.132119780710589 3215 2187.63636363636 2082 0.00937612880123802 879 1.15805443345915 -0.989969802455457 -1 3.46971316346503 3213 879 2082 2055 1834 3403 3264 2089 1207 3034 1004 2034 M10326 GO_NEURON_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_RECOGNITION.html The process in which a neuronal cell in a multicellular organism interprets its surroundings. 43/63 Gene Ontology BP GO:0008038 0.000369654431104698 0.00196571664906304 1190 1845.81818181818 2085 3.36105960735913e-05 429 1.61537192115491 1.48506835785764 1 14.9368737309291 1190 3063 429 2512 2601 856 554 3694 2085 897 2423 2035 M11052 GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. 23/43 Gene Ontology BP GO:0045939 0.0126235526976491 0.024710723896576 385 2207.81818181818 2085 0.00115423396717462 272 1.15102222363922 1.04838631036759 1 6.31379003718753 383 3150 1301 4499 2085 714 272 4256 3436 2604 1586 2036 M14988 GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 44/66 Gene Ontology BP GO:0071391 0.102955432088832 0.137067704008394 3090 2180.18181818182 2085 0.00982862861175828 197 1.1394167765977 1.18056055514129 1 3.35149792178844 3087 197 2085 634 1760 2801 2113 3959 2026 952 4368 2037 M12491 GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 28/41 Gene Ontology BP GO:0035710 0.0778123706934053 0.108077898757139 3155 2184.81818181818 2086 0.00733718443561396 601 1.1880889255267 -1.10143221604192 -1 3.91431107019075 3152 2722 2086 601 1633 3209 2728 1766 652 1334 4150 2038 M13257 GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of receptor activity. 49/62 Gene Ontology BP GO:2000273 0.00116100071353881 0.0043955543694842 3260 2059.90909090909 2088 0.000105601259882407 191 1.03549963895175 -0.99339234477452 -1 8.33382027746702 3260 191 1888 2088 417 1010 2958 2906 4097 2516 1328 2039 M13211 GO_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 91/128 Gene Ontology BP GO:0060191 5.85376612012504e-08 1.54758941800806e-06 3585 1943.54545454545 2090 5.32160570534747e-09 52 1.33325372209621 1.24574177350866 1 26.4747707686239 3585 52 131 527 2090 3687 2832 3080 1938 249 3208 2040 M10441 GO_DENDRITIC_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_MIGRATION.html The movement of a dendritic cell within or between different tissues and organs of the body. 13/48 Gene Ontology BP GO:0036336 3.42376550390649e-05 0.000335904000263133 3625 2500 2091 3.11256253423577e-06 76 1.35965272736796 -1.23624942911743 -1 16.1375078520878 3625 1175 1661 1248 76 4303 4489 4286 197 2091 4349 2041 M15321 GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. 61/68 Gene Ontology BP GO:2001244 0.0884801792905126 0.120874419917427 1540 2076 2091 0.00838662889707674 1004 1.0103047457862 1.02491336647126 1 3.1591182821285 1670 1538 2361 1832 3432 2091 1004 1536 2209 2837 2326 2042 M10470 GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. 48/70 Gene Ontology BP GO:0060688 0.0745778990770119 0.104238799761291 870 2336.18181818182 2092 0.00702117377736219 867 1.24749887860723 1.29698370630955 1 4.17757248904652 867 3729 1189 4022 4005 2092 1501 2924 2140 1791 1438 2043 M11930 GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. 25/29 Gene Ontology BP GO:0045947 0.00100034911379516 0.00397491411314166 1760 2347.81818181818 2092 9.09822060410332e-05 400 0.67818401234768 -0.708498638270465 -1 5.55571708201812 1758 3131 3900 3770 400 1440 851 2092 1794 4137 2553 2044 M13768 GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 69/88 Gene Ontology BP GO:0072527 0.0577945080265592 0.0842210603969872 780 2525.36363636364 2092 0.00539737100957119 779 0.846864113643147 -0.843602342701087 -1 3.10065679230697 779 4026 3756 3488 4390 994 1421 1350 1392 4091 2092 2045 M10357 GO_AMINO_ACID_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_ACTIVATION.html The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. 52/52 Gene Ontology BP GO:0043038 0.130221017316887 0.167612280380491 1380 2338.18181818182 2094 0.0126031917895526 1004 0.666109606029282 -0.695277141435199 -1 1.75589826316188 1376 3044 4086 2671 2225 1004 1496 2094 1417 4337 1970 2046 M11434 GO_RETINOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. 27/44 Gene Ontology BP GO:0042572 0.000478910120039225 0.00236056015735436 3215 1939.36363636364 2094 4.35467640046344e-05 289 1.62890314411515 -1.5465558772339 -1 14.6193687046112 3215 2735 458 1454 289 2608 3439 1601 2094 505 2935 2047 M13898 GO_NEGATIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEATH.html Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 939/1365 Gene Ontology BP GO:0060548 0.0184008957780876 0.0332631577526967 1680 2185.36363636364 2095 0.00185550623142345 628 1.10763074370686 1.14385684906892 1 5.58655993800198 1678 1293 4458 885 2900 2022 2095 3358 2267 628 2455 2048 M15097 GO_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of ions within an organism or cell. 500/819 Gene Ontology BP GO:0050801 4.59126140210232e-15 1.0681569651991e-12 2470 1753.63636363636 2095 4.1738740019112e-16 15 1.26599459788412 -1.18028760379039 -1 51.805821068011 2469 602 15 261 3253 2855 2913 2087 2095 33 2707 2049 M13484 GO_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 377/583 Gene Ontology BP GO:0052547 4.88828734330212e-07 9.39884339189454e-06 2100 2081.27272727273 2096 4.44389857223171e-08 184 1.15974876625142 1.24866809729589 1 19.9217004823733 2096 1931 184 1479 1371 2633 2509 3499 3386 625 3181 2050 M13772 GO_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within an organism or cell. 70/109 Gene Ontology BP GO:0030104 0.016463095001458 0.0304826028817286 2415 2218.36363636364 2096 0.00150796348875719 877 1.44557259261508 -1.62756236212052 -1 7.48166235424782 2411 3017 877 1991 2974 1749 3812 2096 3447 923 1105 2051 M12335 GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 34/35 Gene Ontology BP GO:0009225 0.000324977862219746 0.00181247811833771 2740 1989.18181818182 2098 2.95478069975308e-05 235 0.949799217434565 -0.906602676432965 -1 8.89258523297464 2738 280 3091 969 235 2098 3297 3989 469 1833 2882 2052 M12672 GO_HIPPOCAMPUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPOCAMPUS_DEVELOPMENT.html The progression of the hippocampus over time from its initial formation until its mature state. 84/129 Gene Ontology BP GO:0021766 0.084184575952698 0.115788008249454 2445 2109.18181818182 2098 0.0079627134528642 903 1.12527702517384 1.26463746251914 1 3.5916696568401 1469 1497 2098 2442 3387 2063 903 2566 1998 2334 2444 2053 M11962 GO_RESPONSE_TO_NERVE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NERVE_GROWTH_FACTOR.html A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. 50/59 Gene Ontology BP GO:1990089 0.0389094661522573 0.0609581636385365 1400 1993.36363636364 2099 0.00360137819740659 765 1.05521912426687 0.960450004754751 1 4.37262473891107 1397 2656 3202 2956 2099 1136 765 1150 1033 2893 2640 2054 M12468 GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 13/24 Gene Ontology BP GO:0010758 0.0306216927536574 0.0499588837246731 980 2068.72727272727 2099 0.00282330997255724 976 1.48606431030469 1.81224959905752 1 6.60139407809962 976 2867 988 2545 1280 1650 2306 3381 3497 2099 1167 2055 M10205 GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 18/30 Gene Ontology BP GO:0035588 0.0405700564489422 0.0628612962560533 1115 2215.36363636364 2100 0.00375801000261905 754 0.994104236592355 1.08806662014257 1 4.07338006909731 1113 2321 1391 4119 2100 1888 754 1167 4540 2639 2337 2056 M12217 GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. 412/567 Gene Ontology BP GO:0044283 0.00754597813392421 0.0165463884340949 3820 2124.09090909091 2100 0.000688362339826548 618 1.15006433379276 -1.202769921471 -1 6.9934130399815 3817 618 750 925 1660 2537 3860 3247 2100 662 3189 2057 M13527 GO_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. 82/126 Gene Ontology BP GO:0021675 0.0776459052441697 0.107911110245257 820 1918.81818181818 2100 0.00732089604212906 817 1.23559788492559 1.28192236786174 1 4.07409526660667 817 2100 1395 2903 2143 1741 1507 2868 2494 2244 895 2058 M13648 GO_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 563/777 Gene Ontology BP GO:0007507 0.00719500117207353 0.016003030809588 1210 1988.09090909091 2100 0.000721840350204962 191 1.18493455299481 1.22880771447422 1 7.26452501817682 1208 1909 4440 2379 2539 2100 2344 1362 2883 514 191 2059 M14920 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 16/24 Gene Ontology BP GO:0042347 0.0646709725164897 0.0923899401655593 2295 2471.18181818182 2100 0.00605946788224569 786 0.930742538599857 -0.786026090989766 -1 3.28088476992141 2295 1769 3085 1554 4471 1925 786 4388 1807 3003 2100 2060 M10709 GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 271/326 Gene Ontology BP GO:0060828 0.135137192770077 0.173316802083564 2105 2165.90909090909 2101 0.0131118614925401 660 1.09423164617477 1.1342294860921 1 2.83692598725425 2101 660 1347 844 2455 4030 3204 2391 1936 1611 3246 2061 M11777 GO_SYNAPTIC_VESICLE_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_RECYCLING.html The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. 28/39 Gene Ontology BP GO:0036465 0.00517243042174227 0.0129394186840682 3465 1825.72727272727 2101 0.000471330138804714 130 1.14375525095298 -1.29848235895352 -1 7.37257943678628 3463 321 3063 408 2927 2101 3411 1470 225 2564 130 2062 M15322 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein. 20/31 Gene Ontology BP GO:0042522 0.00577426225782821 0.0134540021460564 2510 2129.27272727273 2101 0.000526315789473684 234 1.14912620545343 -1.07052109511975 -1 7.34070931913963 2510 387 1703 234 4216 2894 2101 3371 659 1393 3954 2063 M13542 GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. 63/94 Gene Ontology BP GO:0050891 0.0114197897251367 0.0229431267664339 3530 2165.90909090909 2102 0.00104359110140053 741 1.58221095988153 -1.81209590906217 -1 8.85738047001911 1959 3032 806 2325 3381 1404 3529 2102 3529 1017 741 2064 M13812 GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. 21/36 Gene Ontology BP GO:0002437 0.0220595360447516 0.0383712228845716 1050 2505.09090909091 2104 0.00202580764911183 406 1.41784968814058 1.22150458668958 1 6.85344564683293 1049 4501 2104 4389 3560 1151 406 2014 3370 2928 2084 2065 M13997 GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. 51/57 Gene Ontology BP GO:0045992 0.0148922233602735 0.0281560578398895 195 1829.18181818182 2104 0.00136309068203552 191 1.1879171437437 1.17630823505109 1 6.28628679029038 191 2147 857 2232 1444 2206 1865 2104 3645 2622 808 2066 M15206 GO_STEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 43/70 Gene Ontology BP GO:0016126 0.000114325230451815 0.000832480903430819 2105 1851.72727272727 2104 1.03937429009621e-05 147 0.914208979197443 -0.963516526616842 -1 9.61511517968131 2104 208 3074 796 147 2305 3629 1434 545 3454 2673 2067 M11003 GO_POLYOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 87/118 Gene Ontology BP GO:0019751 0.00322288254094099 0.00923816811064314 3845 2072.36363636364 2105 0.000293419417971245 60 1.04119158179823 -1.09892699604323 -1 7.231402464499 3844 60 2105 469 608 3563 4410 2649 670 2486 1932 2068 M11468 GO_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORELIMB_MORPHOGENESIS.html The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 34/58 Gene Ontology BP GO:0035136 0.0395181349885704 0.0617039872824893 1755 2388.54545454545 2106 0.0036587610655893 1037 1.29247407082678 0.970935275261144 1 5.33482315227014 1754 2201 1037 1488 4628 2106 1735 4551 2216 1832 2726 2069 M12854 GO_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 75/117 Gene Ontology BP GO:0051963 1.45610582418352e-06 2.36071790938185e-05 1960 1956.54545454545 2106 1.32373344357433e-07 217 1.60021555148001 1.48216350855862 1 25.3036571811848 1956 2106 217 2265 1648 2458 2158 3983 832 526 3373 2070 M12500 GO_LYMPHOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. 339/544 Gene Ontology BP GO:0046649 0.0106253218226302 0.0216555507843619 2575 2381.45454545455 2107 0.000970635321730612 800 1.12971632793131 1.08980846166416 1 6.41810236454307 2575 1361 800 1505 3846 2096 2107 3829 2374 1100 4603 2071 M13400 GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT.html Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. 21/37 Gene Ontology BP GO:0060632 0.0174228832794146 0.0318540966204779 2455 1825.45454545455 2108 0.00159658301384282 593 0.960047769602515 -1.06887189205559 -1 4.90247686648268 2454 1059 2419 593 2561 1438 2982 811 2108 2927 728 2072 M13920 GO_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that modulates the frequency, rate or extent of protein acetylation. 75/101 Gene Ontology BP GO:1901983 0.0699880366364138 0.0991035710496754 820 2496.09090909091 2108 0.0065744593294997 697 0.853596343368476 0.924642040875876 1 2.91915122543758 820 2108 3374 3444 4502 697 1267 1612 4265 3939 1429 2073 M12343 GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. 58/66 Gene Ontology BP GO:1900024 0.0197279486112444 0.0351375514749004 2770 1836.72727272727 2109 0.00180973702793275 625 1.14828626163673 -1.07211694478832 -1 5.69853702526312 2769 866 2164 625 1123 2314 3373 2180 1651 2109 1030 2074 M10193 GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. 70/79 Gene Ontology BP GO:0061097 0.0187520768039479 0.0337406857574515 3080 2104.36363636364 2110 0.00171944064487459 372 1.28586449117294 1.42818932212923 1 6.46001871701577 3079 2110 1212 372 1562 3438 3527 2446 574 617 4211 2075 M15244 GO_GLUCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. 26/33 Gene Ontology BP GO:0009250 2.94966341436296e-05 0.000300982102347168 1810 1809.45454545455 2111 2.68154814808854e-06 70 0.951761831670976 0.960581169042041 1 11.4482491023238 1807 1659 3078 599 70 2614 626 2111 2151 2845 2344 2076 M11969 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. 497/647 Gene Ontology BP GO:0055086 0.028752869743916 0.047681498883924 350 2146.09090909091 2112 0.00264869799270196 349 0.925030644030959 -0.832102865714688 -1 4.16922897298043 349 2458 3886 1456 4035 394 867 2112 2252 3953 1845 2077 M16382 GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. 43/171 Gene Ontology BP GO:0050853 0.00302866261053076 0.00884088276461707 1880 2147.90909090909 2112 0.000275712737951388 330 1.30316476104597 1.27892668933195 1 9.13862688916902 1877 1592 1159 2192 1550 3274 2112 330 3929 2146 3466 2078 M14281 GO_MESODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. 30/48 Gene Ontology BP GO:0048333 0.00917942650462554 0.0193441447128726 2245 2231.63636363636 2113 0.000837995690192091 884 1.38748587924754 1.66302252900537 1 8.11750286319467 2243 1655 1149 2113 884 3246 3068 3683 1158 1905 3444 2079 M16481 GO_DEVELOPMENTAL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. 228/357 Gene Ontology BP GO:0021700 0.0186379322682687 0.0335872574919653 1610 2176.72727272727 2113 0.00170888430556081 612 1.15162242783573 1.06151440251462 1 5.79228400305705 1610 2957 895 3704 3685 612 1483 2193 3072 1620 2113 2080 M15769 GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to a muscle, across a synapse. 21/40 Gene Ontology BP GO:0007274 0.0214996985544154 0.0375524859243524 1340 1845.54545454545 2115 0.00197388423923162 829 1.1455841210421 1.13536797032943 1 5.5720382540571 1336 1082 2380 2307 2146 2646 1638 892 829 2930 2115 2081 M16346 GO_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGIONALIZATION.html The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 257/438 Gene Ontology BP GO:0003002 0.000865630655335818 0.00358982124712795 2120 2403.90909090909 2116 7.87246764956879e-05 490 1.17167247265137 1.14458256640065 1 9.78343811068097 2116 1955 490 2763 3564 1733 1833 4500 2567 1413 3509 2082 M16358 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE.html Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. 24/40 Gene Ontology BP GO:0043576 0.0145734545462631 0.0276663745425387 1335 2092.45454545455 2116 0.00133371803155115 1020 1.00821381806239 1.10955630597559 1 5.35997458106231 1333 1707 2154 3237 1020 2116 3206 1053 3284 2692 1215 2083 M10878 GO_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. 7/16 Gene Ontology BP GO:0006182 0.0251032480685436 0.0427701989245453 1435 2508.27272727273 2117 0.00253914181683682 829 0.91006194389159 0.91006194389159 1 4.24847809661091 1435 3266 4268 3714 1226 2117 829 1567 4484 3402 1283 2084 M12774 GO_PIGMENT_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. 42/55 Gene Ontology BP GO:0046148 0.0574430127296886 0.0838401311892224 975 2137.09090909091 2117 0.00536364560468229 543 0.790231345236404 -0.87155140269444 -1 2.8979110666341 971 2178 3854 2555 1507 1298 2117 2346 543 4195 1944 2085 M14739 GO_HINDBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_MORPHOGENESIS.html The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. 57/80 Gene Ontology BP GO:0021575 0.0152711755757782 0.028709810082463 3400 2235.45454545455 2117 0.00139802011872101 145 1.33228532915638 1.3665472042319 1 7.01302987721341 3397 145 863 351 2117 4127 3891 3355 1163 948 4233 2086 M14057 GO_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION.html The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. 30/73 Gene Ontology BP GO:0030101 0.0879784744358645 0.120330347310428 3030 2333.81818181818 2118 0.00833702414918495 466 1.18770335207135 1.32838561687625 1 3.72365345549501 3027 1650 2226 2066 1683 2017 2118 4185 466 2720 3514 2087 M11277 GO_PH_REDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PH_REDUCTION.html Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. 40/49 Gene Ontology BP GO:0045851 0.194707381917421 0.238038215465518 2120 2398.09090909091 2119 0.0194938139246184 381 1.00211037881133 1.31777347204782 1 2.12504710968082 2119 2685 3115 3228 4548 1281 1778 1988 381 3333 1923 2088 M11307 GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 22/29 Gene Ontology BP GO:0071480 0.0376485762483887 0.0593496628830951 1980 2352.54545454545 2120 0.00348261156167851 690 0.893887767342504 -0.979397737213249 -1 3.73796148783957 1978 2799 3452 3969 2120 2029 1388 1140 2518 3795 690 2089 M14661 GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. 48/59 Gene Ontology BP GO:0050775 0.00284049978135601 0.00837569422221135 1490 1972.90909090909 2120 0.000258561263331522 575 1.02955034046536 1.22583126342992 1 7.30025921973612 1487 896 2228 1885 575 2743 2530 2944 2489 2120 1805 2090 M11053 GO_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 321/412 Gene Ontology BP GO:0051186 0.00282140322508782 0.00835473154166559 2025 2062.81818181818 2121 0.000256820732768624 574 0.99241260860935 -0.946907008801803 -1 7.04023377779581 2025 643 3431 1442 574 1312 2321 3022 2121 2835 2965 2091 M12408 GO_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_DEVELOPMENT.html The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. 218/277 Gene Ontology BP GO:0060348 2.76929314580646e-07 5.75246473546314e-06 1685 2092.45454545455 2121 2.51753954036066e-08 172 1.2675119521076 1.36328382779381 1 22.6978070616356 1684 2510 172 1598 2796 4624 2769 2121 3258 962 523 2092 M10869 GO_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WOUNDING.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. 566/807 Gene Ontology BP GO:0009611 8.03138782934417e-07 1.4263376935091e-05 1265 2063.27272727273 2122 8.0313907319892e-08 102 1.27706669953637 1.21907245089378 1 21.1470871601112 1263 1323 4267 2275 2122 2033 2208 2739 2008 102 2356 2093 M11784 GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 178/213 Gene Ontology BP GO:0032869 0.267008503914898 0.316129915703823 1275 2077.36363636364 2122 0.0278433150176299 719 1.00847742651249 1.08339278385171 1 1.71376630897564 1271 719 2893 807 4370 2932 2261 2519 1268 2122 1689 2094 M10929 GO_ACTIVATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_GTPASE_ACTIVITY.html Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. 85/108 Gene Ontology BP GO:0090630 0.00577426225782821 0.0134540021460564 3980 2030.63636363636 2123 0.000526315789473684 68 1.06589759608596 -1.17014929589668 -1 6.80826608510726 3979 68 2472 124 4358 2524 3687 1869 427 2123 706 2095 M10535 GO_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COCAINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. 45/70 Gene Ontology BP GO:0042220 0.0100525748163485 0.0207426299869044 2195 2182.81818181818 2125 0.000918073143535711 828 1.02808102505308 1.32165908907328 1 5.9054850730311 2192 1585 1932 2125 907 3074 3435 997 3689 3247 828 2096 M10648 GO_EMBRYONIC_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. 32/46 Gene Ontology BP GO:0000578 0.0114769588529835 0.0230083108758865 2130 1955.90909090909 2126 0.00104884298295601 504 1.36915616925369 1.01895574714272 1 7.65747422844166 2126 3101 2275 2183 943 1633 1025 3116 504 2488 2121 2097 M14332 GO_MECHANORECEPTOR_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANORECEPTOR_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. 61/96 Gene Ontology BP GO:0042490 0.385414827906857 0.437412754569685 2785 2338.63636363636 2127 0.0432902743478008 1497 1.20974546745748 1.15048542626638 1 1.47463040232101 2782 2127 2092 1649 2410 2158 2125 4571 1497 2280 2034 2098 M11936 GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 87/142 Gene Ontology BP GO:0019217 0.00329023324848083 0.00938654525149067 2075 1786.45454545455 2130 0.000299560392661795 72 0.989119090083967 1.0693113663144 1 6.84580798693425 2073 72 2353 386 613 2130 2787 1483 2557 2487 2710 2099 M10661 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. 5/23 Gene Ontology BP GO:0051818 9.53444626129408e-05 0.00071902396197409 1735 1942.36363636364 2131 9.53485536149253e-06 3 1.64471807898054 1.98676511020512 1 17.6645123415488 1733 559 4254 85 141 3373 3390 3463 3 2234 2131 2100 M13307 GO_CELL_DIFFERENTIATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_HINDBRAIN.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. 23/41 Gene Ontology BP GO:0021533 0.0115735364406647 0.0231321585302461 2280 1944.09090909091 2131 0.00105771577725081 320 1.72719323542751 1.75129538508036 1 9.64893984226482 2276 380 810 320 3752 2240 2131 3906 1365 909 3296 2101 M16007 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. 16/23 Gene Ontology BP GO:1903427 0.0165089320509139 0.0305310257682441 4465 2436.45454545455 2131 0.00151219394409301 469 1.08375211955841 -1.10521959596333 -1 5.60381204602764 4462 469 2291 2131 1059 4061 4142 1893 767 1401 4125 2102 M16391 GO_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSPORT.html The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 94/164 Gene Ontology BP GO:0006814 5.28358235418099e-09 1.82107471807438e-07 2215 1773.09090909091 2131 4.80325669715471e-10 100 1.58636845112274 1.41361766632148 1 36.5433667235824 2214 795 100 260 2721 4413 2370 2131 962 237 3301 2103 M15234 GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. 5/23 Gene Ontology BP GO:0051883 9.53444626129408e-05 0.00071902396197409 1735 1969.45454545455 2132 9.53485536149253e-06 4 1.64471807898054 1.98676511020512 1 17.6645123415488 1734 560 4544 86 142 3374 3391 3460 4 2237 2132 2104 M16593 GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. 734/956 Gene Ontology BP GO:0034622 0.0690421536935264 0.0979729006209144 1155 2663.27272727273 2132 0.00712859820306407 731 0.94449129780094 -0.996316172648239 -1 3.24722362483674 1154 3620 4638 3801 4389 731 1569 2132 1675 4378 1209 2105 M12378 GO_PALATE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALATE_DEVELOPMENT.html The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. 118/155 Gene Ontology BP GO:0060021 0.000155379727291462 0.00104132677153963 1435 2383 2133 1.41264274912536e-05 373 1.27534438317666 1.18438154698886 1 12.9936579152434 1433 3315 373 4102 955 2133 1982 4375 3737 1304 2504 2106 M12872 GO_PROTEIN_O_LINKED_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_FUCOSYLATION.html The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. 18/19 Gene Ontology BP GO:0036066 0.000380881883597839 0.00200025261221394 150 1990.36363636364 2133 3.46316219048125e-05 89 1.17363127203126 1.25868692438275 1 10.8189598500302 150 3867 2149 4152 4226 923 119 89 3861 2133 225 2107 M14286 GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE.html Any process in by an organism or tissue maintains a population of neuronal stem cells. 30/36 Gene Ontology BP GO:0097150 0.170063507189307 0.211183746717866 1925 2210.72727272727 2133 0.0168032327358501 1306 1.29210937953999 1.20803743511944 1 2.97275353432865 1923 2716 2201 2133 3770 2281 1306 2093 1948 2303 1644 2108 M16846 GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY.html Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. 9/22 Gene Ontology BP GO:0051482 0.00459267184874541 0.0118457328781665 4125 2427 2133 0.000460219123501453 317 2.14230684171984 1.77130596900388 1 14.0994064307319 4124 545 4648 317 738 4147 4513 2133 1171 561 3800 2109 M12454 GO_SPHINGOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. 11/13 Gene Ontology BP GO:0046519 0.0730892242803221 0.102628026343498 4650 2121 2134 0.00687606625616879 159 1.2735030518409 -1.48380514428781 -1 4.29432467382179 4650 1220 3021 1095 1731 2951 2443 1455 159 2472 2134 2110 M13071 GO_RESPONSE_TO_SALT_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. 18/30 Gene Ontology BP GO:0009651 0.00789509889504707 0.017150277851846 3030 2222.09090909091 2134 0.000720325005517399 570 1.02211903186167 -0.964592702007113 -1 6.15980239062922 3028 1762 2261 3106 1891 1956 1818 570 3648 2134 2269 2111 M11477 GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 17/20 Gene Ontology BP GO:0010763 0.000979999945195932 0.0039156949437776 4005 2248.81818181818 2135 8.91306148219465e-05 396 1.15458487126357 -0.906804615744679 -1 9.49163988739268 4002 2302 1774 2135 396 624 1518 3849 2599 1477 4061 2112 M12169 GO_LATERAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. 6/14 Gene Ontology BP GO:0048368 0.0909513409893822 0.123488544181888 1915 2148 2136 0.0094903453055194 160 1.54606643490287 -1.5250441973449 -1 4.79092582024992 1912 2919 4351 2136 2191 2120 1006 3398 160 2422 1013 2113 M14468 GO_RESPONSE_TO_VITAMIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. 33/35 Gene Ontology BP GO:0033197 0.00707521871640816 0.0157592114348718 330 2325.09090909091 2136 0.000645279605254385 329 1.39925285234571 1.20209086240498 1 8.6122816059896 329 3771 735 3877 1778 1657 886 3283 4182 2942 2136 2114 M14682 GO_KIDNEY_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. 15/27 Gene Ontology BP GO:0072074 0.13254188621975 0.17036392170732 1625 2143.90909090909 2137 0.0128430022144726 1341 1.20071140831026 1.04792709065685 1 3.14466209046299 1625 2331 1341 2821 1888 2535 1635 3070 2137 2376 1824 2115 M15020 GO_ASYMMETRIC_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. 38/51 Gene Ontology BP GO:0008105 0.00180061958327617 0.00608003114730334 4545 2290.54545454545 2137 0.000163826819589654 248 1.29081640805085 -1.35997439729016 -1 9.76947813728992 4543 2195 2758 1061 1563 3751 2137 248 1851 3515 1574 2116 M15673 GO_AXONEME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_ASSEMBLY.html The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 53/98 Gene Ontology BP GO:0035082 0.0202878455864938 0.0359890756820266 3160 2154.54545454545 2138 0.00186158060066559 499 1.39554833089132 -1.49046662593807 -1 6.87828914976405 3159 2138 909 499 4650 1936 3338 2276 1206 1218 2371 2117 M10364 GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. 56/86 Gene Ontology BP GO:0048641 0.126859337067236 0.163965693159402 2570 2233.72727272727 2139 0.0122568660598222 166 1.06553640913341 -1.09350706654646 -1 2.85000226520124 2567 166 1872 1371 1843 2941 1863 4317 2902 2590 2139 2118 M13102 GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS.html Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 167/252 Gene Ontology BP GO:0010565 0.00261953573136321 0.00788402312938746 2560 1793.72727272727 2139 0.000238423637893706 308 0.968674719898791 -0.855052105688097 -1 6.95498834141846 2558 713 2498 308 565 1110 2139 3197 1823 2666 2154 2119 M13541 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 101/147 Gene Ontology BP GO:0010522 0.00369770255229991 0.0101988203769125 3965 2320.18181818182 2141 0.000336721110732168 641 1.11101433123901 -1.16372127634139 -1 7.55385938542901 3965 785 641 2343 1637 2141 4622 2900 1741 1642 3105 2120 M10044 GO_TRNA_AMINOACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_AMINOACYLATION.html The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. 52/52 Gene Ontology BP GO:0043039 0.130221017316887 0.167612280380491 1375 2341.63636363636 2142 0.0126031917895526 1003 0.666109606029282 -0.695277141435199 -1 1.75589826316188 1375 3043 4085 2670 2224 1003 1495 2142 1416 4336 1969 2121 M13180 GO_POSITIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_T_CELL_SELECTION.html The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. 20/30 Gene Ontology BP GO:0043368 0.0014139944108045 0.00510420170168607 2855 2303.54545454545 2142 0.000128627639871379 453 1.459113008526 1.28826993018785 1 11.4236386367566 2851 4502 1524 2123 453 2142 2156 1786 2656 1388 3758 2122 M16689 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. 18/23 Gene Ontology BP GO:0034391 0.152911389903 0.192869801360439 3620 2320.54545454545 2143 0.0149731321901056 1016 1.05457429623271 1.16090406331926 1 2.56634139191913 3618 1118 2507 1697 2749 3785 1817 1850 1016 2143 3226 2123 M10352 GO_CELLULAR_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 24/40 Gene Ontology BP GO:0098586 0.0442681488793164 0.0672695983754418 2145 2128.36363636364 2144 0.00410771251353579 624 0.890836770403813 -0.81511555312068 -1 3.55947762132365 2144 1701 3087 1668 4084 916 2419 1248 2399 3122 624 2124 M10786 GO_VESICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. 316/377 Gene Ontology BP GO:0016050 0.00577426225782821 0.0134540021460564 3030 2333.72727272727 2144 0.000526315789473684 183 0.998148934292801 -0.986762904700187 -1 6.37485362200523 3029 645 3646 183 834 2144 4096 3675 2014 4089 1316 2125 M16627 GO_NEPHRIC_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_MORPHOGENESIS.html The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. 17/25 Gene Ontology BP GO:0072178 0.0442053303789932 0.0672695983754418 475 2206.27272727273 2144 0.00410176194839801 474 1.15469766560219 1.09502383747525 1 4.61693333276821 474 3541 2088 3434 1665 1054 607 2144 3885 3080 2297 2126 M16767 GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM.html A circulatory process that occurs at the level of the vasculature. 146/233 Gene Ontology BP GO:0003018 2.64330904440379e-12 2.15777490940541e-10 2125 2072 2144 2.40300822218815e-13 39 1.464447311418 1.38275789776596 1 48.385695517802 2125 744 39 1746 4204 3262 2760 2609 2144 62 3097 2127 M12871 GO_PROTEIN_LOCALIZATION_TO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMATIN.html Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. 16/19 Gene Ontology BP GO:0071168 0.00144326783753601 0.00516976539496155 245 1625.27272727273 2146 0.000131292321478424 218 2.18070673417893 -2.18070673417893 -1 17.0370620963956 244 2336 2320 2146 4290 323 564 218 2648 2444 345 2128 M13239 GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. 322/377 Gene Ontology BP GO:1903320 0.132280256275099 0.170074615210841 2450 2269.45454545455 2146 0.0128159394007895 393 0.851448419048545 -0.853725512351999 -1 2.22898980455237 2450 637 4088 393 3722 1676 3213 2146 1552 3898 1189 2129 M15892 GO_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. 121/178 Gene Ontology BP GO:0007498 0.11351632648214 0.149122379198588 1185 2105.45454545455 2147 0.0108940948598211 1103 1.23183997778041 1.25162366316518 1 3.47004105425203 1182 3313 1342 4185 2235 1245 1498 2147 2637 2273 1103 2130 M16332 GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. 51/56 Gene Ontology BP GO:1904031 0.0126375188669793 0.0247172657789217 1365 2384.36363636364 2147 0.00115551837540549 584 0.860101374345907 0.959397040386674 1 4.71494664198315 1361 3362 3133 3858 978 1205 584 1523 4364 3713 2147 2131 M11501 GO_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of the process of creating protein polymers. 184/225 Gene Ontology BP GO:0032271 0.0508602242037054 0.0757093076138369 2690 2235.45454545455 2148 0.00473414062302705 697 1.0429539845143 -1.08158140754795 -1 3.98607215404463 2690 2963 3292 2148 3707 1190 2990 1417 1530 1966 697 2132 M13948 GO_OOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. 40/71 Gene Ontology BP GO:0009994 0.0029301615067211 0.00859649526530473 1360 2139.36363636364 2148 0.0002667337688025 96 1.2551682000014 0.931233557266786 1 8.85389532744237 1358 3070 2025 3343 4595 362 96 2348 1219 2969 2148 2133 M16339 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 48/52 Gene Ontology BP GO:0070059 0.00320610336605465 0.00920864133472364 755 1860.72727272727 2148 0.000291889567150578 340 0.906064809428108 0.963968981874644 1 6.29582764546129 754 2148 2859 2873 2636 555 368 340 3575 3082 1278 2134 M13290 GO_REGULATION_OF_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of fatty acid transport. 33/57 Gene Ontology BP GO:2000191 0.0281334529977642 0.0469529974170003 1590 2414.81818181818 2149 0.00259089067694393 989 1.10844958433907 1.23101808126881 1 5.02337568851025 1587 3770 2075 3622 2895 1715 1297 989 4301 2163 2149 2135 M13561 GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 23/31 Gene Ontology BP GO:2000463 0.001136330304386 0.00433033980860612 2115 2014.45454545455 2149 0.000103356150855682 195 1.58743622776911 -1.71651834620963 -1 12.8167855507279 2115 4144 1348 215 3655 2208 3676 195 2149 2155 299 2136 M12436 GO_GLYCOGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. 26/33 Gene Ontology BP GO:0005978 2.94966341436296e-05 0.000300982102347168 1810 1817.36363636364 2150 2.68154814808854e-06 69 0.951761831670976 0.960581169042041 1 11.4482491023238 1806 1658 3077 598 69 2613 625 2211 2150 2841 2343 2137 M11739 GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT.html The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. 13/21 Gene Ontology BP GO:0060712 0.000122607323152685 0.000878193138107993 3460 2162.63636363636 2151 1.11467415150655e-05 151 1.06343648695288 -1.12521535193907 -1 11.1019346584032 3458 1184 2151 3036 151 2303 3570 1867 1270 2097 2702 2138 M16895 GO_RECEPTOR_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CLUSTERING.html The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. 49/64 Gene Ontology BP GO:0043113 0.0203518387844939 0.0360339063410389 2140 2587.27272727273 2151 0.00186750775587662 1133 1.27396033192418 1.24599743361323 1 6.27573014882678 2136 2151 1490 2140 1133 4583 2736 3599 2957 1872 3663 2139 M10325 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. 23/25 Gene Ontology BP GO:0061339 0.345360364130994 0.397664383643037 2310 2287.72727272727 2152 0.0377831982763717 463 1.10286622176656 1.01874232151753 1 1.49941626320824 2307 1696 2489 1354 3853 1625 2006 4303 463 2152 2917 2140 M12077 GO_NEGATIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BINDING.html Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 66/89 Gene Ontology BP GO:0043392 0.0874509495412564 0.119644007120102 1220 2322.27272727273 2152 0.00828489326043334 1168 1.49893165323129 1.85270488656089 1 4.71493263066319 1217 2609 1994 4322 4446 2152 1168 1528 1242 2265 2602 2141 M10865 GO_BETA_AMYLOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). 16/25 Gene Ontology BP GO:0050435 0.000305574554885963 0.00172973041835083 4260 2360.18181818182 2153 2.77833642445985e-05 83 1.45813220103404 1.8446263107435 1 13.7587806519027 4257 440 2153 748 229 4276 3608 4147 83 1890 4131 2142 M12148 GO_POLYSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 23/33 Gene Ontology BP GO:0000272 0.00831356200725328 0.0178756950183685 1900 1975.90909090909 2154 0.000758649570474851 152 1.03285548731816 1.04935280175909 1 6.16108369061542 1899 1047 2749 546 862 3811 2896 2989 152 2154 2630 2143 M14937 GO_REGULATION_OF_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cilium assembly. 56/66 Gene Ontology BP GO:1902017 0.00577426225782821 0.0134540021460564 2685 1898.45454545455 2154 0.000526315789473684 172 1.0271674325424 -1.04108362037632 -1 6.56049535232133 2685 874 3278 172 3540 1496 2154 2445 927 2898 414 2144 M13567 GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. 9/12 Gene Ontology BP GO:0008655 0.00127044834444436 0.00472533664804125 2160 1987 2156 0.000127117524693899 70 0.670392213161684 -0.670392213161684 -1 5.31962041655517 2156 2409 4437 2553 450 725 70 603 3233 4549 672 2145 M10087 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 108/165 Gene Ontology BP GO:0051928 0.000619503520625402 0.00284275136239645 2500 2056.54545454545 2157 5.63343669981559e-05 463 1.20316350643216 -1.26821006386959 -1 10.4635166331379 2500 1457 463 1054 2157 3149 3161 4108 2837 567 1169 2146 M14337 GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE.html Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. 9/12 Gene Ontology BP GO:0043097 0.00127044834444436 0.00472533664804125 2160 2008 2157 0.000127117524693899 71 0.670392213161684 -0.670392213161684 -1 5.31962041655517 2157 2410 4488 2554 451 726 71 752 3234 4572 673 2147 M15074 GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 44/87 Gene Ontology BP GO:0002275 0.14878300479024 0.18817268858086 1625 2303.72727272727 2157 0.014537673881813 1210 1.16668536955293 1.06124821561224 1 2.88301197225551 1624 2172 1776 2179 4383 1820 1210 3006 2157 1518 3496 2148 M13109 GO_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ADAPTATION.html A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 33/50 Gene Ontology BP GO:0043500 0.101323589258186 0.135321085194701 1905 2645.72727272727 2158 0.00966501360081594 1407 1.12312718869286 1.1797088272844 1 3.32481807204262 1903 4435 1902 4240 2999 2703 1656 1620 4080 1407 2158 2149 M10230 GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that activates or increases the frequency, rate or extent of reproductive process. 51/84 Gene Ontology BP GO:2000243 0.00732239006709413 0.0162021781295408 1835 2364.27272727273 2159 0.000667897798479013 741 1.43388709515794 1.52998636222618 1 8.76669691483775 1833 2651 741 4007 3551 2159 1534 2347 3926 1985 1273 2150 M12127 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an external stimulus. 281/449 Gene Ontology BP GO:0032103 1.03362789490125e-06 1.76171084065037e-05 1245 1913.81818181818 2159 9.39662164119864e-08 208 1.27539123369232 1.33108383167369 1 20.7194180177992 1242 2485 208 1798 3518 2039 2159 2587 2491 267 2258 2151 M15707 GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. 49/60 Gene Ontology BP GO:0045668 0.0186261346407344 0.0335790021245011 2400 2087.90909090909 2160 0.00170779329849988 615 1.36572239395976 1.39918943922381 1 6.87161759355944 2396 1582 1081 2689 3359 2160 1869 2823 2045 615 2348 2152 M10297 GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. 15/17 Gene Ontology BP GO:1904872 0.0433530168278524 0.0663994691573394 2165 2242.72727272727 2161 0.00402106054291795 238 0.858988733265625 -0.858988733265625 -1 3.44844815437539 2161 2845 3826 1671 3289 1957 597 1550 238 3870 2666 2153 M15584 GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. 14/16 Gene Ontology BP GO:0070234 0.07149725084406 0.100902853556995 3080 2534.18181818182 2161 0.00672112401263915 852 1.78405790222595 -1.87969949426784 -1 6.06512788213845 3077 3899 1295 2161 3480 3020 4385 1928 2141 1638 852 2154 M14404 GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. 15/17 Gene Ontology BP GO:1904874 0.0433530168278524 0.0663994691573394 2165 2234.72727272727 2162 0.00402106054291795 239 0.858988733265625 -0.858988733265625 -1 3.44844815437539 2162 2846 3827 1672 3290 1958 598 1444 239 3879 2667 2155 M15444 GO_MYOTUBE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_CELL_DEVELOPMENT.html The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 24/39 Gene Ontology BP GO:0014904 0.0285646772236022 0.0474959513292895 3995 2555.90909090909 2162 0.00263113130678348 1246 1.11746486301652 -1.05067756044501 -1 5.04524164547078 3995 2752 2162 1823 1246 2062 4029 3999 2746 1359 1942 2156 M16219 GO_SINGLE_ORGANISM_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CATABOLIC_PROCESS.html A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism. 868/1233 Gene Ontology BP GO:0044712 0.00406677595503362 0.0109253513387826 2990 1957.09090909091 2165 0.000407423758056171 11 1.17225288049567 -1.10720281127171 -1 7.85103492542525 2987 581 4605 11 767 706 2945 4037 2165 465 2259 2157 M11887 GO_PHAGOLYSOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOLYSOSOME_ASSEMBLY.html The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. 15/19 Gene Ontology BP GO:0001845 0.0100508059699628 0.0207426299869044 4645 2365.36363636364 2166 0.000917910855668418 636 1.4082828266417 -1.41996801257957 -1 8.09337688396509 4644 1785 2349 1808 1727 3435 3686 636 875 2908 2166 2158 M12049 GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of endothelial cell development. 13/14 Gene Ontology BP GO:1901550 0.109871375169468 0.14486582846799 1825 2539.54545454545 2167 0.0105250656139503 1586 1.0472082506561 0.77308246406416 1 2.99337272971761 1824 2369 2067 2165 1783 2167 1586 2969 4387 3281 3337 2159 M12992 GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrate derivative. 532/665 Gene Ontology BP GO:1901137 0.00525070999993344 0.0130510436056038 3635 2310.45454545455 2167 0.000526315789473684 20 1.11255709232147 -1.01108511936887 -1 7.15699719981788 3631 601 4399 20 2167 1383 3280 4294 1701 714 3225 2160 M13051 GO_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that modulates the frequency, rate or extent of a response to a food stimulus. 13/22 Gene Ontology BP GO:0032095 0.00389992387288569 0.010593157876888 2160 2032.54545454545 2167 0.000355168585958444 290 1.88703378108908 2.30726523853616 1 12.7312197793656 2159 2367 2110 2167 3199 3107 2781 383 510 3285 290 2161 M14578 GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. 13/14 Gene Ontology BP GO:1903140 0.109871375169468 0.14486582846799 2170 2539.81818181818 2168 0.0105250656139503 1587 1.0472082506561 0.77308246406416 1 2.99337272971761 1825 2370 2068 2166 1784 2168 1587 2953 4388 3291 3338 2162 M16143 GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. 257/339 Gene Ontology BP GO:0034612 0.0304482962258793 0.0497632322932969 2120 2546.45454545455 2168 0.00280709593315168 1277 1.08165738583043 1.18548372451572 1 4.80833832249056 2120 1953 1737 2168 1277 4462 3167 2507 3541 2000 3079 2163 M16972 GO_AMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 16/24 Gene Ontology BP GO:0009309 0.0140244800030633 0.0267881385280188 2170 1961.90909090909 2168 0.00128315353332593 293 1.4791982718823 -1.92176069963205 -1 7.93970513865684 2168 3889 2514 3474 3317 467 293 988 559 3011 901 2164 M11294 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 17/18 Gene Ontology BP GO:0033145 0.00258262229600824 0.00781843952070679 1595 2327.09090909091 2171 0.000235059916187143 304 0.805901654693944 -0.864066350827402 -1 5.79449798615413 1593 2822 3486 2894 3687 1893 2171 304 1735 3964 1049 2165 M10430 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. 24/45 Gene Ontology BP GO:0045956 0.0726390799160385 0.102204305669588 1595 2189.72727272727 2172 0.00683223046998263 1048 1.16226503519526 -1.11596383651413 -1 3.92543231504296 1591 2754 1860 2994 2172 1250 2282 1449 3564 3123 1048 2166 M14207 GO_GOLGI_TO_VACUOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_VACUOLE_TRANSPORT.html The directed movement of substances from the Golgi to the vacuole. 37/38 Gene Ontology BP GO:0006896 0.0232934578472978 0.0401275303085807 2415 2296.09090909091 2172 0.00214034603397657 394 0.881779374513921 -0.792993593710111 -1 4.19961936475017 2415 2696 3890 2172 3875 952 1559 2042 1115 4147 394 2167 M11753 GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. 26/36 Gene Ontology BP GO:0060122 0.045122285109279 0.068344398637199 1250 2213.63636363636 2173 0.00418865699670944 880 1.12577722439974 1.21918991881753 1 4.47453434485486 1250 4130 2686 4154 1419 1037 880 2173 2363 3257 1001 2168 M15943 GO_REGULATION_OF_CELL_SHAPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SHAPE.html Any process that modulates the surface configuration of a cell. 174/204 Gene Ontology BP GO:0008360 0.0442825660485661 0.0672695983754418 2175 2264.45454545455 2173 0.00410907824903774 871 1.17419951655253 1.29188625214875 1 4.69508945232385 2173 2005 1069 1980 2178 3627 2482 1899 3223 871 3402 2169 M12259 GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. 36/55 Gene Ontology BP GO:0043534 0.0285437086306267 0.0474959513292895 1555 2378.81818181818 2174 0.00262917420117848 998 1.13286741319976 1.13752285668238 1 5.11492958246458 1553 4091 1682 3664 2174 1549 1196 998 4190 2743 2327 2170 M14921 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT.html Any process that activates or increases the frequency, rate or extent of protein import. 148/215 Gene Ontology BP GO:1904591 0.0969703507431389 0.130443203818394 1475 2326.36363636364 2174 0.00922985837963407 1472 1.07601894751014 1.16059162982521 1 3.24357094947395 1472 3303 2795 3659 2009 2585 1658 1591 2174 2621 1723 2171 M15227 GO_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MORPHOGENESIS.html The process in which bones are generated and organized. 97/125 Gene Ontology BP GO:0060349 3.65778045734135e-06 5.36897554195878e-05 2175 2328.45454545455 2174 3.32526048989256e-07 236 1.34024143069298 1.365329258201 1 19.5558925244316 2174 2064 236 1661 1551 4060 3713 2737 3346 880 3191 2172 M12218 GO_ANATOMICAL_STRUCTURE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. 59/76 Gene Ontology BP GO:0071695 0.00465499576620765 0.0119468810260144 1040 2365 2176 0.000424079507385571 417 1.21653935067023 1.18217695563237 1 7.98658174854425 1038 3711 1397 4143 3926 2653 1538 417 3665 2176 1351 2173 M13081 GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). 38/42 Gene Ontology BP GO:0072350 0.000162937598311868 0.00107215004509877 1930 2167.72727272727 2176 1.48136061033118e-05 151 0.931267510242556 -0.647612070522279 -1 9.4448687534629 1930 2176 3581 1849 179 1431 2499 3378 151 3787 2884 2174 M16215 GO_DNA_PACKAGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING.html Any process in which DNA and associated proteins are formed into a compact, orderly structure. 152/328 Gene Ontology BP GO:0006323 0.113634852105439 0.149235948870055 1105 2238.09090909091 2176 0.0109061180027829 1104 1.11403830162816 -1.36191430032555 -1 3.13591973091791 1177 2538 3116 3257 3513 1105 2176 1950 1593 3090 1104 2175 M10724 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 42/68 Gene Ontology BP GO:0051966 0.00231580376492658 0.00722214136608806 4445 2567.54545454545 2177 0.000210749551512002 592 1.44928508767856 -1.59601193645258 -1 10.5997103807896 4441 2177 592 1799 796 4043 4272 4587 2166 836 2534 2176 M16728 GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. 326/481 Gene Ontology BP GO:0002237 1.3498189685595e-06 2.20375707393241e-05 580 1908.09090909091 2177 1.22710890613377e-07 215 1.17794311175822 1.21693205461916 1 18.7439328456214 580 2480 215 2319 4428 1129 1626 2213 3594 228 2177 2177 M16833 GO_CARDIAC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. 59/93 Gene Ontology BP GO:0055006 0.00953240778415398 0.019961428181669 1605 2206.36363636364 2177 0.000870360288362747 218 1.25540612406778 1.25767506105916 1 7.28519955518199 1603 3355 1094 3163 3426 2052 2205 1188 3789 2177 218 2178 M16908 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 17/32 Gene Ontology BP GO:0032225 0.000665335806977019 0.00298823118712748 2925 2294.81818181818 2177 6.05033733306386e-05 333 1.29378247172821 -1.33197928159741 -1 11.1565249670378 2923 1775 2177 2816 333 3285 3822 3594 1012 2048 1458 2179 M10486 GO_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical. 783/1214 Gene Ontology BP GO:0048878 2.52716134487067e-12 2.13797849776059e-10 2735 2166 2178 2.52716134487354e-13 19 1.2372698439708 -1.19760174016852 -1 40.8949751302588 2731 1304 4245 681 2366 2114 2698 2031 2178 19 3459 2180 M11710 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. 33/53 Gene Ontology BP GO:0036092 0.108547113641722 0.143444964434801 4520 2348.36363636364 2178 0.0103913323021476 845 1.09584739347446 -1.22318630739357 -1 3.14893768330769 4518 965 2178 1621 3532 2708 2748 1660 845 2161 2896 2181 M15818 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. 41/61 Gene Ontology BP GO:1901016 0.138932644930869 0.177353524516689 885 2237.72727272727 2179 0.013506372770849 883 1.03873918802712 0.992658844577005 1 2.65700347778421 883 2179 2259 2139 3947 1882 1207 3406 3109 2384 1220 2182 M10725 GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. 29/44 Gene Ontology BP GO:0007202 6.03438114775967e-05 0.000512371815338061 4075 1933.72727272727 2180 5.48595151926172e-06 275 1.49821845814098 -1.45345814580358 -1 16.8439277854584 4075 275 322 504 818 2856 2180 3713 2333 589 3606 2183 M10361 GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. 9/20 Gene Ontology BP GO:0002861 0.0890926319993597 0.121639676259689 1955 2605.54545454545 2181 0.00928800438598426 954 1.47436325717896 1.83135828711942 1 4.60126283046337 1955 3596 4236 3544 1973 3836 3771 1599 954 2181 1016 2184 M10170 GO_HINDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). 160/247 Gene Ontology BP GO:0030902 0.0652759332758962 0.0931112561412461 3220 2586.09090909091 2182 0.00611792780306045 391 1.16122829404299 -1.14198071256527 -1 4.08258255236402 3217 1418 1160 391 1896 4225 3830 4345 2182 1510 4273 2185 M15789 GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cell differentiation. 910/1237 Gene Ontology BP GO:0045597 1.16786122223186e-06 1.94769113514153e-05 1465 2271.18181818182 2182 1.16786183598724e-07 113 1.22601861588836 1.26411770385763 1 19.7342235800422 1465 2441 4572 1996 3447 1655 2106 2330 2676 113 2182 2186 M14941 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 40/70 Gene Ontology BP GO:0009948 0.0216167737321139 0.0376858817124909 995 2059.54545454545 2184 0.00198474041091665 380 1.31877029023764 1.22313958648176 1 6.40907169886509 995 2184 1754 2663 3892 1306 1129 3466 2253 2633 380 2187 M16425 GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. 119/153 Gene Ontology BP GO:0001936 1.11304247121502e-05 0.000139220070391492 2040 2448 2184 1.01186191132075e-06 260 1.41267641573196 1.38494602435012 1 18.6147418692697 2039 2050 260 3285 4315 4304 3056 3149 1762 524 2184 2188 M11464 GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. 9/20 Gene Ontology BP GO:0007216 0.00317735377654214 0.00914299760188658 3590 2261.27272727273 2185 0.000318190594932106 549 1.28019422203024 -1.42520548894143 -1 8.91348255927397 3590 549 4304 1539 630 2800 1177 2861 1204 2185 4035 2189 M11577 GO_VENTRICULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. 40/67 Gene Ontology BP GO:0021591 0.10448647506511 0.138748735296221 1385 2143 2185 0.00998238324194234 1299 0.974359047670171 1.11424889770245 1 2.84681451492233 1382 2185 2588 1876 1767 2431 1299 1800 2625 3334 2286 2190 M14878 GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. 162/266 Gene Ontology BP GO:0050866 1.10382409265899e-06 1.86767036477901e-05 2110 2022.81818181818 2186 1.00347695135465e-07 133 1.29983031180473 1.2969688759045 1 21.0039222985642 2109 2011 209 524 3084 2857 3021 2186 2238 133 3879 2191 M10069 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. 100/140 Gene Ontology BP GO:1903214 0.234991051002124 0.281662380296981 2825 2365.45454545455 2187 0.0240575050180275 1120 0.925758462681248 -0.960290702646877 -1 1.73101121031303 2823 2065 3540 1120 2151 1392 2888 2459 2187 3708 1687 2192 M12839 GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. 22/25 Gene Ontology BP GO:0060716 0.0365304546067537 0.0579530191903256 2190 1889.27272727273 2188 0.00337741094014926 106 1.16263889605761 1.67564072845927 1 4.90611139478528 2188 350 2254 850 1341 3717 3592 1128 106 2529 2727 2193 M13557 GO_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAT_CASCADE.html An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with activation of STAT proteins by kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 46/85 Gene Ontology BP GO:0097696 0.000894491420940609 0.00366057043239811 4155 2415.54545454545 2188 8.13504833351579e-05 384 1.04637505598733 -1.03825700255707 -1 8.70574461149764 4152 897 2188 627 384 4071 3511 3715 760 1654 4612 2194 M14003 GO_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE.html Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 46/85 Gene Ontology BP GO:0007259 0.000894491420940609 0.00366057043239811 4155 2420.36363636364 2189 8.13504833351579e-05 385 1.04637505598733 -1.03825700255707 -1 8.70574461149764 4153 898 2189 628 385 4072 3512 3758 761 1655 4613 2195 M15269 GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html A process in which a protein is transported to, or maintained in, a location within the mitochondrion. 80/92 Gene Ontology BP GO:0070585 0.015080894804588 0.0283979779545723 450 2493.90909090909 2189 0.00138047970439117 446 0.612828035404984 -0.611320674690134 -1 3.23005092819421 446 4014 4139 4289 2189 549 748 772 4374 4606 1307 2196 M13433 GO_MESONEPHRIC_TUBULE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHRIC_TUBULE_MORPHOGENESIS.html The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. 57/83 Gene Ontology BP GO:0072171 0.00042151209357365 0.00215764111264928 995 1938.72727272727 2190 3.83266250404809e-05 437 1.36555778382573 1.25675730819349 1 12.4363757098379 993 3036 437 2797 3055 1178 1252 2746 2877 765 2190 2197 M13947 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. 26/38 Gene Ontology BP GO:0070229 0.0148915234416774 0.0281560578398895 1540 2042.09090909091 2191 0.00136302617923469 627 1.0374801564488 0.978429337544745 1 5.48884555378324 1539 2745 2191 3259 1023 1525 627 3613 2277 2414 1250 2198 M16752 GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT.html Any process that modulates the frequency, rate or extent of synaptic vesicle transport. 46/58 Gene Ontology BP GO:1902803 0.0414628575642328 0.0640952412778655 1795 2215.09090909091 2191 0.00384232355356202 589 1.10363153959563 -1.12969504404408 -1 4.49149160248852 1794 3374 3154 2191 1564 1482 2737 3200 1314 2967 589 2199 M12406 GO_COMPLEMENT_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION.html Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. 38/240 Gene Ontology BP GO:0006956 2.11241328031857e-07 4.59301822117865e-06 1415 1971.18181818182 2192 1.92037589377269e-08 162 1.8994618742051 1.72091540889105 1 34.6545268929269 1411 2192 162 2244 1096 3051 2700 4092 2801 391 1543 2200 M16885 GO_LACTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATION.html The secretion of milk by the mammary gland. 50/88 Gene Ontology BP GO:0007595 0.00909885013508742 0.019207993607793 3290 1979.54545454545 2192 0.00083060917062982 192 1.60259139537571 -1.37613430008172 -1 9.39444088547188 3288 192 775 1345 3036 2836 2192 4297 724 647 2443 2201 M11566 GO_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_MOVEMENT.html Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. 97/158 Gene Ontology BP GO:0030048 0.0238516204604469 0.0409677334818971 515 2203.90909090909 2193 0.0021922005116304 512 1.06211748284316 0.917648524966849 1 5.02800986088225 512 3672 1875 3078 2674 2304 1904 933 3783 2193 1315 2202 M10216 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 77/133 Gene Ontology BP GO:0034763 0.123871646868851 0.160729161427987 2195 2401.45454545455 2194 0.0119500852812174 1088 0.994274004188234 0.97788051670145 1 2.68811559408114 2194 1506 1881 1918 3363 2311 1088 4087 2365 1997 3706 2203 M11385 GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 79/160 Gene Ontology BP GO:0001676 0.000966614296835082 0.00387395032142432 2905 1893.54545454545 2194 8.79126599740439e-05 461 1.19858544286105 -1.17299171415984 -1 9.87284214675308 2904 813 500 461 2194 2446 2266 2030 2646 522 4047 2204 M11979 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. 36/79 Gene Ontology BP GO:2000107 0.00451781886228309 0.0116915523727493 200 1811.81818181818 2194 0.000411556655289763 116 0.982669406203991 0.920817720054218 1 6.48069742784606 284 2697 2194 3934 3710 199 197 906 2951 2742 116 2205 M13617 GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 35/45 Gene Ontology BP GO:0060314 0.0150257279097685 0.0283170157813498 1485 2057.81818181818 2194 0.00137539489957641 524 0.898709058535827 1.05650061769619 1 4.74563651011836 1484 2194 1974 2411 1026 2705 2403 1159 4084 2672 524 2206 M14880 GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that stops or reduces the activity of a monooxygenase. 13/24 Gene Ontology BP GO:0032769 0.000103176467560979 0.000765677996110422 4535 2360.54545454545 2194 9.38011878994283e-06 139 1.14481950388168 -1.38250328695864 -1 12.185422504749 4534 1828 2255 2194 139 3678 4335 255 982 1502 4264 2207 M14456 GO_MONOCARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSPORT.html The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 112/209 Gene Ontology BP GO:0015718 4.83576484563955e-06 6.75700114917743e-05 3075 1970.09090909091 2196 4.39615952276885e-07 24 1.25283054623805 -1.36919779526664 -1 17.8520093535011 3072 24 243 263 3978 2809 1861 2515 2196 352 4358 2208 M13343 GO_PALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. 202/287 Gene Ontology BP GO:0021543 0.00598411734927061 0.0138047089866912 1965 2176.36363636364 2198 0.000545496065742662 714 1.14320070714186 1.28157698802913 1 7.25912083163333 1963 1981 714 2472 1771 2530 2198 2724 3048 941 3598 2209 M10879 GO_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SECRETION.html The controlled release of proteins from a cell. 114/190 Gene Ontology BP GO:0009306 0.110065090875317 0.145039044985231 1975 2608.27272727273 2199 0.0105446435606871 1667 1.13446263782122 1.34675021544195 1 3.2416588814373 1973 3663 1931 3957 3083 1824 2010 1667 3754 2630 2199 2210 M11069 GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of epithelial cell migration. 210/251 Gene Ontology BP GO:0010632 0.00028473609087911 0.00164785700355783 1020 1837.36363636364 2199 2.58884499697897e-05 294 1.22013056497255 1.32534122999323 1 11.5991305840108 1019 2516 414 2456 3313 2866 2199 1173 2205 294 1756 2211 M12181 GO_ESTABLISHMENT_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization or cell growth patterns. 124/172 Gene Ontology BP GO:0030010 0.0173361331836956 0.0317578849227306 2200 2566.72727272727 2200 0.0015885699378302 1071 0.964650166179677 0.856432196581375 1 4.93036285923397 2200 2045 3274 1923 1071 1858 1547 4431 2298 3635 3952 2212 M13425 GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM.html Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. 19/41 Gene Ontology BP GO:0030277 0.0568559929007409 0.0832706751549094 800 2413.81818181818 2200 0.00530734748558618 725 1.40504201160995 1.18658361577585 1 5.17503928102331 796 3858 1230 4203 3516 1699 725 2200 4099 2248 1978 2213 M14875 GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune effector process. 147/270 Gene Ontology BP GO:0002699 0.00870602064739251 0.0185226859041232 1200 2261.36363636364 2200 0.000794605901434758 595 1.11761168979923 1.1687651000995 1 6.60853666989535 1200 3307 2052 3394 3158 1751 1221 595 3407 2200 2590 2214 M16810 GO_AMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving AMP, adenosine monophosphate. 16/18 Gene Ontology BP GO:0046033 0.00745163910721778 0.0163858585850115 2605 2399.63636363636 2200 0.000679727177793596 557 0.778599287654045 -0.875365395953075 -1 4.74240238320724 2601 1776 3174 2999 1979 2200 1994 557 3898 3509 1709 2215 M10580 GO_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. 16/22 Gene Ontology BP GO:0046209 0.00577426225782821 0.0134540021460564 4570 2308.72727272727 2201 0.000526315789473684 131 1.32970098060347 1.24543150316902 1 8.49591085375922 4570 474 964 131 2372 4044 4051 1741 2201 957 3891 2216 M12068 GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. 12/17 Gene Ontology BP GO:0032460 0.0334449455293905 0.0537359570263308 2205 2106.81818181818 2201 0.00308767957625885 1081 1.05102008956551 -0.608720501738028 -1 4.55198068644393 2201 2886 2773 2397 1875 2953 1081 1090 1162 3192 1565 2217 M15776 GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION.html The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. 26/35 Gene Ontology BP GO:0021799 0.157096520945038 0.197506109688534 1815 2586.81818181818 2201 0.0154165497576234 1682 1.26114124849435 1.42719319238632 1 3.02663590406205 1813 3806 3327 3875 2201 2068 1948 1864 1682 2849 3022 2218 M10131 GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 44/65 Gene Ontology BP GO:0050854 0.138721114384836 0.177180715133858 2200 2499.54545454545 2202 0.0134843440603917 904 1.00423173000492 1.02670171778574 1 2.56983583014873 2199 904 2047 1000 1894 3125 3070 3031 3891 2202 4132 2219 M15370 GO_NEURAL_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_FORMATION.html The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. 124/142 Gene Ontology BP GO:0001841 0.0430536261876067 0.0660496283056162 2055 2194.45454545455 2202 0.00399272821820385 651 1.11133827664431 1.13388635634529 1 4.47336614307187 2051 758 2580 651 1400 3946 3229 3113 1034 3175 2202 2220 M11087 GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. 60/90 Gene Ontology BP GO:0046928 0.0309908848345386 0.0504727291337445 3170 2294.63636363636 2203 0.00285784133450772 1284 1.05237573951845 -0.967628443574868 -1 4.65576134854389 3170 1546 2385 1612 1284 1651 2203 2869 1864 2208 4449 2221 M16349 GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. 911/1347 Gene Ontology BP GO:0007417 3.18381831306475e-07 6.41311974488756e-06 1940 2075.63636363636 2206 3.1838187692163e-08 90 1.19026626969732 1.21852443075734 1 21.1217491238003 1936 580 4616 695 1271 3349 2679 2711 2206 90 2699 2222 M10182 GO_CYTOKINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 10/19 Gene Ontology BP GO:0042107 0.000205425729424384 0.0012873468850097 485 2060.90909090909 2207 1.86768103298082e-05 57 0.968170851726693 0.968170851726693 1 9.55660673266187 482 4249 2910 4158 3671 692 179 57 2207 3613 452 2223 M11343 GO_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_ARREST.html A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). 176/219 Gene Ontology BP GO:0007050 0.265276799916808 0.314479732487365 1495 2209 2207 0.0276347447592255 1315 0.982854795857908 1.04216279267771 1 1.67759112796756 2747 1408 3060 1315 2207 1494 1988 2980 1494 2758 2848 2224 M12791 GO_POLYOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSPORT.html The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/22 Gene Ontology BP GO:0015791 0.0816046681119307 0.112639134003208 2210 2353.18181818182 2207 0.00770898096201181 1074 1.39488282217921 1.48831150276398 1 4.51186034916368 2207 2882 1784 3459 1652 3484 1629 3041 2716 1957 1074 2225 M15949 GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN.html The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. 9/16 Gene Ontology BP GO:0002016 0.150268502640725 0.189793524100785 2970 2191.81818181818 2207 0.0161516271996749 429 1.46097596165125 -1.4026024319252 -1 3.59432167623354 2968 550 4582 874 2396 3580 3171 1883 429 1470 2207 2226 M15081 GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION.html Any process that activates or increases the frequency, rate or extent of dendrite extension. 17/29 Gene Ontology BP GO:1903861 0.00577426225782821 0.0134540021460564 1730 2140.54545454545 2208 0.000526315789473684 101 1.42332356078911 1.16006523129541 1 9.09484804316248 1730 3185 3001 227 4228 3109 2036 644 101 3077 2208 2227 M15666 GO_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_EXTENSION.html Any process that modulates the frequency, rate or extent of dendrite extension. 17/29 Gene Ontology BP GO:1903859 0.00577426225782821 0.0134540021460564 1735 2142.72727272727 2209 0.000526315789473684 102 1.42332356078911 1.16006523129541 1 9.09484804316248 1731 3186 3002 228 4229 3110 2037 658 102 3078 2209 2228 M13535 GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 384/474 Gene Ontology BP GO:0051348 0.0434318532004252 0.0664764516255192 2320 2068.81818181818 2210 0.00402852242987707 523 0.977946319200187 -0.934706314914621 -1 3.92580271776905 2318 1353 3369 1631 2010 523 2480 2210 2952 3033 878 2229 M14444 GO_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. 171/217 Gene Ontology BP GO:0035303 0.365780124904619 0.41879304162923 1870 2461.27272727273 2210 0.0405511992676057 1666 0.988395402834546 1.02104044691848 1 1.26670386629684 1867 2007 3539 1666 3981 2044 1841 2396 2210 3270 2253 2230 M11794 GO_COPPER_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_TRANSPORT.html The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 17/20 Gene Ontology BP GO:0006825 0.00109458906089355 0.00422319146674661 2445 2017.63636363636 2211 9.95576402646729e-05 410 1.24522343311104 -1.19667168179089 -1 10.0978235874802 2442 2825 2211 2979 410 2243 3078 1356 623 2035 1992 2231 M13674 GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-13 production. 28/65 Gene Ontology BP GO:0032656 0.0117005314196647 0.0233058958457618 180 2231.09090909091 2212 0.00106938428347725 177 1.08059326409851 -1.08059326409851 -1 6.02072100115802 177 4129 3088 3110 953 1022 2212 1192 3726 3391 1542 2232 M11321 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION.html The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. 23/23 Gene Ontology BP GO:0006295 0.000501280839139785 0.002430222775983 1740 2189.18181818182 2213 4.55813722634207e-05 295 0.604764027549627 -0.607378321809534 -1 5.39492283325806 1739 3142 3850 2637 295 640 966 2292 1835 4472 2213 2233 M12290 GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY.html Any process that modulates the activity of the enzyme lipoprotein lipase. 7/17 Gene Ontology BP GO:0051004 0.0313149341465974 0.0508403309784081 3245 2603.36363636364 2213 0.00317651709584946 1324 0.677062140279866 0.565784080954534 1 2.98425766389787 3243 1865 4361 1534 1324 2197 2213 1472 2640 3404 4384 2234 M14380 GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 221/383 Gene Ontology BP GO:0071383 0.136264070110464 0.174329589833376 2215 1924.63636363636 2213 0.0132288281335329 578 1.16830226296957 -1.16509938802195 -1 3.01957716909844 2213 686 1468 578 2441 1024 2388 3595 2631 1167 2980 2235 M10777 GO_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MATURATION.html Any process leading to the attainment of the full functional capacity of a protein. 272/391 Gene Ontology BP GO:0051604 0.00497467611761917 0.0125488106828069 4090 2490.09090909091 2214 0.000453269152426059 686 1.18200714906134 -1.03186747446574 -1 7.67330306541135 4089 1946 686 1205 2214 2615 4250 3327 1551 1384 4124 2236 M11086 GO_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. 254/310 Gene Ontology BP GO:0007009 0.13774022591666 0.176121261662605 2090 2340.09090909091 2214 0.0133822589486933 665 1.05149272777881 -1.04067455364158 -1 2.70064260976396 2087 665 1666 1298 3412 3355 2214 1799 2865 2658 3722 2237 M11391 GO_POSITIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BEHAVIOR.html Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 14/31 Gene Ontology BP GO:0048520 0.0120765613985897 0.0238608238588696 3565 2298.36363636364 2214 0.00110394252762142 703 1.61078659498605 1.79429955098675 1 8.9237392937331 1685 3564 1970 3565 2795 2404 1118 703 3192 2214 2072 2238 M16084 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. 22/42 Gene Ontology BP GO:0032733 0.00259358001109329 0.00783123153252245 2045 2217.63636363636 2214 0.000236058421683543 305 1.33598648771728 1.33742802826149 1 9.60962123605506 2041 3819 1883 3607 2655 2214 1068 305 2372 2064 2366 2239 M16455 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION.html The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 23/23 Gene Ontology BP GO:0006293 0.000501280839139785 0.002430222775983 1740 2210.90909090909 2214 4.55813722634207e-05 296 0.604764027549627 -0.607378321809534 -1 5.39492283325806 1740 3143 3851 2638 296 641 967 2354 1836 4640 2214 2240 M16094 GO_SERTOLI_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. 20/26 Gene Ontology BP GO:0060008 2.65498346011183e-05 0.000279494073300913 3525 2001.45454545455 2216 2.41365045570609e-06 65 1.01693809982769 -0.960433705645695 -1 12.3447945859921 3524 398 2216 577 65 3467 2970 103 955 3329 4412 2241 M12325 GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. 14/31 Gene Ontology BP GO:0021895 0.158602183934953 0.199237570693666 3585 2371.36363636364 2217 0.0155765654801964 626 1.10744066877816 -0.900125208131353 -1 2.64211489630215 3583 1183 2488 626 1957 3052 2030 3725 923 2217 4301 2242 M14586 GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. 16/27 Gene Ontology BP GO:0051580 0.0114609373075919 0.0229962809866686 2220 2417.18181818182 2217 0.00104737112473621 687 1.46813557133127 1.46430989255468 1 8.21296130095804 2217 3544 2094 3334 1974 2775 1589 687 4174 3001 1200 2243 M10346 GO_LUNG_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_EPITHELIUM_DEVELOPMENT.html The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. 30/43 Gene Ontology BP GO:0060428 0.0324360317767395 0.0523136415449459 2250 2062.09090909091 2218 0.00299312430300782 395 1.12976956906116 -1.1116523545697 -1 4.93884424844187 2246 2218 2698 395 1303 2297 3644 1676 2675 1901 1630 2244 M10683 GO_AMIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSPORT.html The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 85/124 Gene Ontology BP GO:0042886 0.0475230400210028 0.071445785207666 2580 2388.63636363636 2218 0.00441652391722264 970 1.28639162537625 1.22479364301543 1 5.02966876872643 2580 1485 1083 970 2001 3829 2218 4209 3406 1587 2907 2245 M11633 GO_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_SECRETION.html The controlled release of a peptide from a cell or a tissue. 55/82 Gene Ontology BP GO:0002790 0.0691767765991985 0.0981340065597777 1515 2266.36363636364 2219 0.00649571087384975 1199 1.1010933840807 1.1640218935229 1 3.7847136406463 1511 2137 2219 3008 2075 2238 1199 1426 4120 2538 2459 2246 M14399 GO_GDP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. 15/17 Gene Ontology BP GO:0046710 0.00822756660025738 0.0177317588656774 3125 2045 2219 0.00075077255902109 602 1.15774009947833 -1.21176580517605 -1 6.92121973022225 3124 1170 2502 602 858 2219 4159 903 3667 2374 917 2247 M15138 GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. 37/55 Gene Ontology BP GO:0002053 0.0266033308912818 0.0448335018606065 4305 2509.18181818182 2219 0.0024482348546711 810 1.22476640595319 -1.19857701113587 -1 5.63563231688723 4301 942 962 2219 3072 2543 4516 4190 1896 810 2150 2248 M13101 GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 15/19 Gene Ontology BP GO:0060192 0.240611318893821 0.287805775530321 4200 2312.81818181818 2220 0.0247115034447677 476 0.942404884236495 0.687539688607511 1 1.73213635208171 4197 476 2252 991 3668 4370 2720 2220 1168 1764 1615 2249 M13287 GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. 14/15 Gene Ontology BP GO:0032354 0.00744597748189037 0.0163858585850115 965 2029.90909090909 2220 0.000679208974301146 188 1.41857854142628 1.11096475473706 1 8.64924267544153 963 2862 2594 3333 3835 1175 188 3486 794 2220 879 2250 M13795 GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 12/15 Gene Ontology BP GO:0030207 0.0165207014544607 0.0305406531059219 1715 2201.36363636364 2220 0.00151328021081928 791 1.41442774681564 1.570875419649 1 7.31624456146337 1712 3232 1462 3205 2700 3143 2220 791 2408 1964 1378 2251 M14197 GO_CELLULAR_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 28/32 Gene Ontology BP GO:0036315 0.0188257394374885 0.0338470500782975 4015 2407.18181818182 2220 0.00172625372096382 506 1.4705985063381 -1.17428508230046 -1 7.3827579127808 4015 2220 898 506 2286 2213 4389 2465 1945 2172 3370 2252 M11748 GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. 18/22 Gene Ontology BP GO:0006206 0.00420823825510074 0.0111424891472543 1850 2248.09090909091 2221 0.000383300867807696 162 0.829169607795161 -0.829169607795161 -1 5.52592248549762 1847 4533 3601 4387 2221 383 162 397 2353 3999 846 2253 M14496 GO_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 31/38 Gene Ontology BP GO:0001935 0.00976704471109265 0.020234220409935 1690 2295.72727272727 2222 0.000891879780546679 632 1.39825750594351 1.21570725632033 1 8.08720746881796 1687 2222 1404 2825 3852 3676 3200 632 2492 1247 2016 2254 M16159 GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. 53/67 Gene Ontology BP GO:0035306 0.0666681417104972 0.0949225408136303 2225 2012.63636363636 2222 0.00625259357053489 173 1.05497400762787 1.22955448034296 1 3.67786437309195 2102 173 2717 1610 2586 1823 2223 2222 3432 2420 831 2255 M10662 GO_IRON_COORDINATION_ENTITY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_COORDINATION_ENTITY_TRANSPORT.html The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 10/13 Gene Ontology BP GO:1901678 7.5470192207264e-06 0.00010119965542951 4130 2376.54545454545 2223 6.86095010056642e-07 23 1.38988590653772 1.53816177365576 1 18.9725138917855 4130 1837 2223 1732 23 4559 4005 2483 88 1645 3417 2256 M12743 GO_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYUBIQUITINATION.html Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. 270/313 Gene Ontology BP GO:0000209 0.167886773186006 0.209067383596157 2225 2530.63636363636 2223 0.016569084408699 1035 0.834848173292109 -0.803532870122698 -1 1.92944546527333 2223 1947 4162 1571 3761 1735 2793 2936 1035 4309 1365 2257 M14848 GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING.html Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 14/17 Gene Ontology BP GO:0090036 0.00113579745561267 0.00433033980860612 2285 1936.45454545455 2223 0.000103307659974848 194 1.53485094015417 -1.76745528858348 -1 12.3918645077558 2285 3225 1226 3730 2617 1023 874 194 2820 2223 1084 2258 M15840 GO_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTION.html The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. 1178/2036 Gene Ontology BP GO:0000003 0.00553204303914691 0.0134540021460564 2590 2330.45454545455 2223 0.000554586305905537 487 1.18481542039957 1.16369695774545 1 7.56902601420901 2587 1275 4575 1708 2223 2540 2614 2188 1793 487 3645 2259 M13250 GO_POST_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_MORPHOGENESIS.html The process, occurring after embryonic development, by which anatomical structures are generated and organized. 13/17 Gene Ontology BP GO:0009886 0.00064426670642855 0.00292751268067582 2225 2411.09090909091 2224 5.85868596689757e-05 328 1.32853992338653 1.40898220231247 1 11.4970269833694 2224 2878 2167 3044 328 2086 1577 4627 1305 2699 3587 2260 M14088 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. 82/150 Gene Ontology BP GO:0045621 0.0170976205599362 0.0313827331224391 2855 2540.72727272727 2224 0.00156654192442528 1068 1.10906314344381 -1.07579275808591 -1 5.68962811516969 2852 3331 2140 1102 1068 2224 4303 3414 3646 1982 1886 2261 M16279 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that activates or increases the activity of the enzyme nitric-oxide synthase. 22/27 Gene Ontology BP GO:0051000 0.0524696152281807 0.0777024569244828 1655 2025.54545454545 2224 0.00488767752873519 685 0.98187233395038 1.08642264580658 1 3.71411434430551 1654 2275 2703 2224 3038 2251 685 1687 1144 2065 2555 2262 M14628 GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that modulates the frequency, rate or extent of lamellipodium organization. 68/81 Gene Ontology BP GO:1902743 0.139877911369647 0.178315594959717 3285 2501.27272727273 2225 0.0136048726098019 966 1.21060880303918 -1.01378707243169 -1 3.08867047744723 3284 2118 2225 1645 2161 3793 4246 3281 966 1035 2760 2263 M10415 GO_SKELETAL_MUSCLE_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_TISSUE_REGENERATION.html The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. 30/42 Gene Ontology BP GO:0043403 0.0856851922041248 0.117504626974887 1410 2034.90909090909 2226 0.00811059728009779 778 1.00230756805936 -0.935401700922607 -1 3.17610715307774 1409 2226 2975 1096 2769 778 2830 3007 1222 3114 958 2264 M15784 GO_REGULATION_OF_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_CONDUCTION.html Any process that modulates the frequency, rate or extent of cardiac conduction. 67/91 Gene Ontology BP GO:1903779 0.00112536452194196 0.00430264677123742 610 1964.90909090909 2226 0.000102358235589917 517 1.18782217794558 -1.23312998279229 -1 9.59897684481991 2948 848 517 2758 3959 2226 3308 610 2610 1221 609 2265 M10308 GO_BODY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_MORPHOGENESIS.html The process in which the anatomical structures of the soma are generated and organized. 62/79 Gene Ontology BP GO:0010171 0.014166909589222 0.0270379943882896 1210 1988.54545454545 2228 0.00129626986193638 676 1.20882774386003 1.37756240712689 1 6.46985889039442 676 2617 1049 2228 1014 2695 2626 2781 3775 1207 1206 2266 M12989 GO_ORGANELLE_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_FUSION.html The joining of two lipid bilayers to form a single organelle membrane. 82/104 Gene Ontology BP GO:0090174 0.0027504901817243 0.00819336159767167 2955 1886.45454545455 2228 0.000250357721654181 89 1.13172368862918 -1.24986109007064 -1 8.06278608149337 2955 815 3167 535 2228 2369 3636 1503 496 2958 89 2267 M13739 GO_MAMMARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. 155/219 Gene Ontology BP GO:0030879 8.89064838895168e-09 2.79514776714812e-07 4325 2164.54545454545 2228 8.08240765898234e-10 65 1.42497986018317 -1.44444665725763 -1 31.9180020726068 4392 729 110 209 3604 4322 4322 2644 1185 65 2228 2268 M13935 GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 71/88 Gene Ontology BP GO:0043535 0.414364662925312 0.465934938760627 2230 2566.63636363636 2228 0.0474775798774089 1425 1.00912648954974 1.11332518397293 1 1.13366492840064 2228 1516 2013 1425 2457 4616 3835 3124 2025 1669 3325 2269 M15705 GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. 26/55 Gene Ontology BP GO:0042462 0.119999124999107 0.156446043323296 2230 2470 2228 0.0115538607387964 950 1.08554326158254 -0.791678538924839 -1 2.97938486605536 1816 3125 1978 2547 4360 950 1104 2228 3988 2848 2226 2270 M15746 GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 369/495 Gene Ontology BP GO:0072521 0.0628373581239997 0.0901579486126953 815 2269.18181818182 2229 0.00588248770422256 647 0.897342394542001 -0.760350581118357 -1 3.19534984466972 814 1933 3699 1738 3501 647 1276 2791 2297 4036 2229 2271 M10715 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. 88/147 Gene Ontology BP GO:0070664 0.00735003806633293 0.0162314794127419 3415 2046.81818181818 2230 0.000670428134128763 67 1.2680650925064 -1.19329682011771 -1 7.74823632748408 3412 67 743 503 2690 3991 4534 2230 1261 528 2556 2272 M12417 GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 22/29 Gene Ontology BP GO:0045978 0.00189062914190746 0.00629713485847918 2985 2004.81818181818 2230 0.000172023260215892 83 1.05662292564132 -1.10603936197269 -1 7.94001723562749 2984 2780 2469 2089 502 2230 4122 1666 600 2528 83 2273 M13110 GO_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_PRODUCTION.html The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. 12/36 Gene Ontology BP GO:0032609 0.00769539632371251 0.0167948776239373 660 1939.72727272727 2231 0.00070204060619111 194 0.954892163575285 0.971328421654089 1 5.78364867720361 660 3239 2768 3777 2231 526 194 846 3522 3196 378 2274 M13830 GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. 22/29 Gene Ontology BP GO:1903579 0.00189062914190746 0.00629713485847918 2985 2023.90909090909 2231 0.000172023260215892 84 1.05662292564132 -1.10603936197269 -1 7.94001723562749 2985 2781 2470 2090 503 2231 4123 1865 601 2530 84 2275 M14044 GO_REGULATION_OF_MITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOPHAGY.html Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy). 56/62 Gene Ontology BP GO:1903146 0.00185782143270303 0.00622259271481621 3670 2342.54545454545 2231 0.000169035650350427 499 0.775049006966422 -0.751872430254942 -1 5.83498612277335 3669 1560 3891 2231 499 814 3067 4140 1141 4134 622 2276 M14813 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. 1093/1430 Gene Ontology BP GO:0022603 4.18973289108353e-08 1.18150467528556e-06 1490 2065.45454545455 2231 4.18973297007591e-09 68 1.19921307908623 1.28327606198779 1 24.2926270762961 1486 1279 4517 1175 2661 2811 2340 1798 2231 68 2354 2277 M13122 GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 27/35 Gene Ontology BP GO:0040036 0.00966211385203547 0.0200704534613933 4415 2207.54545454545 2232 0.000882255578345849 628 1.33703469110835 -1.35163825892368 -1 7.74877486384352 4413 2232 1080 1617 3460 2509 3723 628 1051 924 2646 2278 M13864 GO_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MIGRATION.html The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. 121/181 Gene Ontology BP GO:0001764 0.00384728133011415 0.0104809133659374 960 2076.63636363636 2232 0.00035036598511708 648 1.41260092311409 1.54479305713956 1 9.55003390523504 956 3661 648 3559 2259 1846 729 2358 2232 1829 2766 2279 M14342 GO_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASOCONSTRICTION.html Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. 55/92 Gene Ontology BP GO:0019229 3.832823596761e-08 1.0941182942165e-06 3180 2108.54545454545 2232 3.48438514866923e-09 121 1.56524695229679 -1.75183765615057 -1 31.8892666999267 3180 877 121 1258 2911 2505 2232 4019 1978 224 3889 2280 M14720 GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY.html A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. 70/97 Gene Ontology BP GO:0060135 0.024964055928592 0.0426018954950089 740 2222.27272727273 2233 0.00229562854611586 101 1.31948310822454 1.42905452952383 1 6.17231687696239 3068 101 946 740 2719 4099 4644 4024 738 1133 2233 2281 M11906 GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 38/53 Gene Ontology BP GO:0045744 0.044399028449049 0.0674245037119533 2235 2020.18181818182 2234 0.00412011139526824 627 1.2358522296834 -1.45307204512398 -1 4.93794968563143 2234 947 1100 2301 2361 3092 3753 1986 2976 845 627 2282 M12250 GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 232/301 Gene Ontology BP GO:0010821 0.0623403615960186 0.0897229446119802 1655 2451.72727272727 2234 0.00583457190240986 644 0.871162736224833 -0.877060024915066 -1 3.10807178518064 1655 2508 3912 1656 4124 644 2234 1626 2909 4203 1498 2283 M10345 GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. 51/73 Gene Ontology BP GO:0046470 0.000325633399471987 0.00181247811833771 4230 1976.72727272727 2235 2.96074189226269e-05 16 1.36146776977985 -1.31911010156422 -1 12.7514926057454 4226 164 477 16 2276 3507 3958 4154 453 278 2235 2284 M11331 GO_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEPARATION.html The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). 17/21 Gene Ontology BP GO:0051304 0.00519414125012481 0.0129797740262249 2010 2567 2235 0.000473313197006633 152 0.89715447988027 -0.89715447988027 -1 5.77655819586439 2006 4197 3771 3645 3238 990 152 2235 1991 3965 2047 2285 M12359 GO_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 537/935 Gene Ontology BP GO:0034220 0.00024980584080047 0.00148394161260319 3790 2239.27272727273 2236 2.49833926575177e-05 268 1.18602437166893 -1.15193732816398 -1 11.4591145710623 3788 599 4363 453 2614 1042 3603 3550 2116 268 2236 2286 M16196 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. 90/124 Gene Ontology BP GO:0033138 0.241219403657836 0.288458978468237 2240 2337.36363636364 2236 0.0247825263682989 1500 1.17934474170518 1.32295720687115 1 2.16634183151164 2236 2590 1898 3380 2315 2907 2829 2108 1500 2113 1835 2287 M16456 GO_EMBRYONIC_PLACENTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_MORPHOGENESIS.html The process in which the embryonic placenta is generated and organized. 23/31 Gene Ontology BP GO:0060669 0.201485611559558 0.245101320414803 4030 2705.72727272727 2236 0.0202469744584118 958 1.14417306268797 1.05825804137763 1 2.37813616313301 4026 1048 2236 1130 2081 4231 4331 3026 958 2159 4537 2288 M10732 GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS.html The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. 29/43 Gene Ontology BP GO:0060441 0.21156204413156 0.255986254264846 3795 2621.81818181818 2237 0.0213774261560551 1109 1.3234033355036 -1.36852174225114 -1 2.66694766883511 3794 2237 2042 1903 2107 3875 2815 3580 1109 1816 3562 2289 M16905 GO_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_EFFECTOR_PROCESS.html Any process of the immune system that can potentially contribute to an immune response. 447/940 Gene Ontology BP GO:0002252 3.96823129052232e-05 0.000374526981638953 2125 2127.81818181818 2237 3.60754806269481e-06 252 1.2054794273029 1.19246333043338 1 14.1116263327502 2121 1921 303 1733 3891 2772 2309 2518 2237 252 3349 2290 M11398 GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of T cell proliferation. 77/158 Gene Ontology BP GO:0042102 0.0358064613038325 0.0569208966336633 1550 2233.36363636364 2238 0.00330935182406717 458 1.04398725557213 -0.983076575893865 -1 4.43219253741302 1550 3335 2156 1583 2266 458 2238 2535 4384 2769 1293 2291 M14448 GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. 29/36 Gene Ontology BP GO:0060351 0.00750699018776528 0.016491985525813 90 1976.54545454545 2238 0.000684793554154087 90 1.17218075728325 1.26066419878054 1 7.13383758362337 90 2728 747 2238 1376 2361 2606 1714 4462 2243 1177 2292 M15295 GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION.html The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. 55/73 Gene Ontology BP GO:0006929 0.0523917410010439 0.0776118340903717 845 2497.54545454545 2238 0.00488024282273472 684 1.14711308489912 1.16412408505059 1 4.34295024902132 841 3723 1412 3861 4638 1566 684 2428 4360 2238 1722 2293 M16042 GO_MULTICELLULAR_ORGANISM_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_REPRODUCTION.html The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. 683/1283 Gene Ontology BP GO:0032504 0.0686668576788273 0.0975177446685743 2630 2294.09090909091 2238 0.00708857994632346 592 1.14117479086708 1.09505830440305 1 3.93354524345426 2628 592 4588 1723 2238 2626 2759 1468 1767 1345 3501 2294 M12310 GO_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 1662/2794 Gene Ontology BP GO:0009605 2.90608648465689e-18 1.50244671256761e-15 1465 2136.54545454545 2240 2.90608648465691e-19 3 1.30041409349182 1.3309477210349 1 65.8939905820026 1462 1875 4362 2240 2411 1814 2070 2440 2421 3 2404 2295 M11077 GO_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 172/281 Gene Ontology BP GO:0006413 0.0359331083971766 0.057083220680117 125 2660.09090909091 2241 0.00332125395268256 125 0.666771530635141 0.600477070749321 1 2.82407116251821 125 4314 4205 4645 1332 982 549 2241 4417 4431 2020 2296 M11165 GO_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of exocytosis. 164/250 Gene Ontology BP GO:0017157 0.170284123599897 0.211401287916307 4225 2633.90909090909 2241 0.0168269952939051 533 1.07647663073507 -1.16392114880164 -1 2.47322259081235 4225 1410 2241 533 1997 4221 3604 4647 1709 2052 2334 2297 M16857 GO_REGULATION_OF_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. 663/834 Gene Ontology BP GO:0022604 8.88312349175331e-06 0.000116236944661165 1320 2118 2241 8.88315900140041e-07 148 1.19695553445141 1.27506856724903 1 16.0912393825395 1316 1898 4649 1193 2514 2403 2149 2304 2241 148 2483 2298 M10774 GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 27/30 Gene Ontology BP GO:0033158 8.37945918930778e-05 0.000650911913319685 4245 2327.81818181818 2242 7.61798033358841e-06 128 1.07023402980316 -1.52978308525639 -1 11.6488947280827 4244 2242 3275 1952 128 2636 1449 780 1330 3957 3613 2299 M12953 GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION.html Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 16/19 Gene Ontology BP GO:0051127 0.236155036649229 0.282984647316214 4060 2197.63636363636 2242 0.0241925919072022 411 1.12871900914064 -1.22002820180009 -1 2.10500127141167 4059 2337 3020 1391 3154 1368 1688 2242 411 1893 2611 2300 M14426 GO_GROOMING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROOMING_BEHAVIOR.html The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. 9/18 Gene Ontology BP GO:0007625 9.55771229911879e-05 0.000719612222132682 3425 1984.27272727273 2242 9.5581233983935e-06 143 1.93135094642391 2.30672838453813 1 20.7425042048389 3424 544 4493 352 143 2242 2582 2325 614 2881 2227 2301 M11531 GO_BLASTOCYST_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_FORMATION.html The initial formation of a blastocyst from a solid ball of cells known as a morula. 25/34 Gene Ontology BP GO:0001825 0.00460438707544854 0.0118693701174859 2080 2260.63636363636 2243 0.000419459267503041 714 0.862734969681208 -0.960889523686494 -1 5.66909294733795 2077 2243 3341 2820 714 2113 853 2338 1370 3559 3439 2302 M14544 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. 151/288 Gene Ontology BP GO:0002703 0.0357468050826118 0.0568454832704692 1320 2586.54545454545 2243 0.00330374590261446 1120 0.972217396365164 1.03230218143906 1 4.12867822130576 1320 3306 2243 3616 4549 1501 1546 1120 4246 2899 2106 2303 M12374 GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. 27/37 Gene Ontology BP GO:0033081 0.0276387843760137 0.0462934714548566 3010 2322.72727272727 2244 0.00254474957971523 472 1.16685133156642 -1.13681994402677 -1 5.31311718676667 3009 2244 1435 3042 1227 1759 472 2960 3465 1615 4322 2304 M15143 GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 70/102 Gene Ontology BP GO:0060193 6.82723801477422e-07 1.25561812184761e-05 3810 2074.18181818182 2244 6.20658193951372e-08 96 1.4167037091398 1.3612396023224 1 23.728684391187 3808 96 194 562 2244 3930 3123 2888 1977 346 3648 2305 M10515 GO_NEURON_PROJECTION_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION.html Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 72/84 Gene Ontology BP GO:1990138 0.0355913679826467 0.056656392481442 1420 2515.81818181818 2245 0.00328914089056721 1117 1.12166590338535 1.1854531560626 1 4.77052381237286 1418 4022 2215 4014 2245 1675 1452 1117 4089 2811 2616 2306 M12392 GO_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that modulates the frequency, rate or extent of thymocyte aggregation. 27/37 Gene Ontology BP GO:2000398 0.0276387843760137 0.0462934714548566 3010 2323.72727272727 2245 0.00254474957971523 473 1.16685133156642 -1.13681994402677 -1 5.31311718676667 3010 2245 1436 3043 1228 1760 473 2961 3466 1616 4323 2307 M14597 GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS.html A biological process that directly contributes to the process of producing new individuals, involving another organism. 781/1478 Gene Ontology BP GO:0044703 0.204573033164903 0.248337678924157 2720 2522.27272727273 2245 0.0226276895289796 1306 1.17111632284654 1.15447581379587 1 2.41157759926874 2717 1306 4502 2245 2130 2782 2778 2232 1955 1410 3688 2308 M14669 GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. 294/456 Gene Ontology BP GO:0048871 5.0828375309218e-09 1.77822879935182e-07 1430 2123.54545454545 2245 4.62076140242282e-10 98 1.38569134743017 1.34590533006084 1 31.9682349955071 1427 3963 98 4120 2341 2595 2245 1189 3523 262 1596 2309 M12566 GO_EMBRYONIC_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_FORELIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 29/50 Gene Ontology BP GO:0035115 0.0367207627545008 0.0581360017341586 2440 2563.09090909091 2247 0.00339530860733127 1021 1.39104999737058 1.00132904087942 1 5.86554557199183 2437 2221 1021 1990 4101 2780 2247 3934 1870 1417 4176 2310 M12870 GO_POSITIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION.html Any process that activates or increases the frequency, rate or extent of cell adhesion. 385/579 Gene Ontology BP GO:0045785 1.23176134281412e-09 5.02753116501237e-08 1555 2057.72727272727 2248 1.11978303954889e-10 84 1.27540218347481 1.30151721441149 1 31.8153203108405 1555 2947 84 2038 3008 2248 2504 1693 3488 187 2883 2311 M14749 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN.html An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. 31/224 Gene Ontology BP GO:0002455 0.000159325732587829 0.0010544400883759 1070 2155.81818181818 2248 1.44852065684429e-05 375 1.54045143538364 1.71174559524351 1 15.6682544630149 1068 2712 375 2248 4237 3133 2585 2212 2852 928 1364 2312 M15358 GO_RESPONSE_TO_X_RAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_X_RAY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). 35/37 Gene Ontology BP GO:0010165 0.0365616567974794 0.0579693491587308 2250 2540.09090909091 2248 0.00338034515242839 569 0.988488441782434 1.14905352556875 1 4.1692194623167 2248 4080 3158 4544 1588 2079 569 1131 3470 3667 1407 2313 M11071 GO_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH.html Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). 1128/1569 Gene Ontology BP GO:0008219 0.0120656285537327 0.0238493498982661 2250 2155.81818181818 2250 0.00121316443054707 565 1.0720580269508 1.14024596529311 1 5.93638868097576 2250 1277 4277 711 2482 2323 2029 3043 1569 565 3188 2314 M12994 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. 25/26 Gene Ontology BP GO:0032232 0.142865628576385 0.181378927630538 1695 2368.63636363636 2250 0.0139168508527343 1185 1.10055102300939 1.17542490927698 1 2.77907190351115 1694 3133 1980 2778 2236 1236 1185 3056 4168 2339 2250 2315 M16266 GO_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other 765/1247 Gene Ontology BP GO:0055085 9.50332346638394e-06 0.000122490205232921 3620 2285.45454545455 2251 9.50336410754914e-07 152 1.20890869203424 -1.15821727584273 -1 16.1579779620197 3619 587 4610 452 3353 1274 3484 3204 2154 152 2251 2316 M15319 GO_PROTEIN_HOMOTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTRIMERIZATION.html The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. 16/23 Gene Ontology BP GO:0070207 0.202193307699299 0.245705265271569 2255 2295 2252 0.0203259446200426 196 1.44209501072579 1.37977268690413 1 2.99486642054131 2252 1772 2398 1295 2317 4376 2704 4563 196 1898 1474 2317 M16715 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 19/21 Gene Ontology BP GO:0010664 0.0109759107691799 0.0221854530013007 2890 2054.90909090909 2252 0.00100282324512286 667 1.31195830963332 1.49342474469067 1 7.40807506865246 2889 1732 1644 1068 3435 3376 2478 667 2349 2252 714 2318 M11224 GO_CEREBELLAR_CORTEX_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 38/57 Gene Ontology BP GO:0021696 0.052013507824008 0.0771616797059876 4040 2336.72727272727 2253 0.00484414053974417 226 1.37200774414343 -1.23755734915413 -1 5.2083382882643 4036 226 1104 329 3333 4440 4190 2253 797 1115 3881 2319 M14817 GO_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 238/332 Gene Ontology BP GO:0051260 0.118390243650831 0.154521684069374 3790 2658.09090909091 2253 0.0113897108496064 1721 1.13377503125693 -1.17188968906178 -1 3.13307145371534 3786 1960 2023 1721 1818 2047 3380 4200 3063 2253 2988 2320 M13134 GO_CELL_SEPARATION_AFTER_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SEPARATION_AFTER_CYTOKINESIS.html The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components. 17/17 Gene Ontology BP GO:0000920 0.036826373897979 0.0582635558474315 2210 2564 2254 0.00340524227053807 544 0.617364848298855 -0.679742910232642 -1 2.59526067463928 2208 2818 3888 2447 3989 2254 1917 1443 2162 4534 544 2321 M13403 GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 29/38 Gene Ontology BP GO:0045662 0.037734418484377 0.0594575852379973 2255 2041.18181818182 2255 0.00349069278546974 310 1.35561144184491 1.18965623922001 1 5.67059752481122 2255 310 1029 1581 4121 2713 2330 4316 731 807 2260 2322 M16251 GO_REGULATION_OF_CELLULAR_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. 67/95 Gene Ontology BP GO:0030641 0.00236364442731721 0.00732226199754125 1305 1951.90909090909 2256 0.000215107974086198 293 1.15057835709281 1.38100950192455 1 8.3893249588879 1305 3025 2316 3711 2638 655 1226 293 2256 2853 1193 2323 M12519 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. 24/27 Gene Ontology BP GO:0031112 0.000414787683051593 0.00212790197270018 3100 2074 2257 3.77150825191117e-05 274 1.12973493346909 -1.14033734034111 -1 10.3101356110998 3097 2769 3295 1410 274 3182 4422 1063 336 2257 709 2324 M12416 GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. 12/27 Gene Ontology BP GO:1901533 0.00268115104056613 0.00801760654997057 3255 2383.09090909091 2260 0.000244038559882662 88 1.23948638955771 -1.55253743027136 -1 8.87144807696627 3251 1816 2260 2160 3927 4398 4406 914 415 2579 88 2325 M16777 GO_RESPONSE_TO_WATER_DEPRIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER_DEPRIVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. 12/17 Gene Ontology BP GO:0009414 0.0287263716775083 0.047681498883924 1005 2308.09090909091 2260 0.00264622436393045 533 1.08373180580234 -1.42705099839299 -1 4.88634431901908 1003 3915 2351 3504 1249 533 2260 1456 4580 3763 775 2326 M10490 GO_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 75/113 Gene Ontology BP GO:0001656 0.000413204297197216 0.00212211875812213 1360 2200.09090909091 2262 3.75710841542887e-05 436 1.32500891941654 1.2573826183087 1 12.0994335518817 1356 3013 436 3226 4355 1772 1477 2556 2596 1152 2262 2327 M10438 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 17/40 Gene Ontology BP GO:0046189 0.140429529356269 0.178969761735064 3515 2521 2263 0.0136623984785557 1360 1.62772391049466 1.32712586504506 1 4.14769497217419 3513 3192 1360 2137 1980 3152 2263 2538 1472 1476 4648 2328 M12607 GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. 22/34 Gene Ontology BP GO:0002292 0.00284937689718191 0.00839123462189077 3745 2335.27272727273 2263 0.000259370366722272 566 1.16896832952239 -1.19735921799456 -1 8.2870603711112 3742 2263 1891 566 577 3851 3660 2382 572 1550 4634 2329 M14258 GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. 31/50 Gene Ontology BP GO:1901532 0.0563782932988631 0.0826490859230024 1655 2157.72727272727 2263 0.00526155722347633 1340 1.2131765917567 1.06085208104503 1 4.48040310963525 2215 1653 2263 2602 2998 2332 1652 1340 1587 2402 2691 2330 M16011 GO_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). 222/281 Gene Ontology BP GO:0046777 0.165881276904111 0.206873648200169 1405 2317.72727272727 2266 0.0163538482158632 682 0.96529855162488 1.10367540544702 1 2.24771887085612 1402 682 2782 1424 4294 2663 2185 1889 2266 3173 2735 2331 M15257 GO_REGULATION_OF_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ASSEMBLY.html Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 20/28 Gene Ontology BP GO:0090169 0.00881944427661112 0.0186956146783925 2270 2192 2267 0.000804999973983456 217 0.655404834975918 0.637151278533374 1 3.86201357857609 2267 415 3620 913 3719 795 217 3762 3172 4052 1180 2332 M10070 GO_APICAL_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, apical regions of the cell. 23/30 Gene Ontology BP GO:0045176 0.00365354784074339 0.0101190226803446 3580 2326.72727272727 2268 0.000332693585909792 367 1.19884628998078 -1.26304319122823 -1 8.16586010181374 3580 2268 2706 1513 1275 3945 3724 367 1900 3825 491 2333 M13412 GO_CARDIOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. 14/19 Gene Ontology BP GO:0010002 0.0259982066632554 0.0440370060444585 2270 2460.63636363636 2270 0.00239187436560574 1190 1.29952288474526 1.15497419617617 1 6.01485533862111 2270 2863 1617 1647 1211 2542 1190 4407 3876 1633 3811 2334 M13010 GO_LEUKOCYTE_TETHERING_OR_ROLLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_TETHERING_OR_ROLLING.html Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). 15/17 Gene Ontology BP GO:0050901 0.103438980993692 0.137593361510478 775 2322.27272727273 2271 0.00987716310490481 775 1.50808112156194 1.800784971117 1 4.430771722903 775 3561 1466 3107 2271 1521 1259 3019 4618 2911 1037 2335 M11163 GO_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of muscle contraction. 147/232 Gene Ontology BP GO:0006937 4.23411941600981e-08 1.18682877365625e-06 2890 1922 2272 3.8491995431815e-09 122 1.26000530719166 1.27000168298135 1 25.5162325887336 1347 1429 122 2272 1870 2869 2803 2463 2887 190 2890 2336 M11612 GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 50/61 Gene Ontology BP GO:0010591 0.0291595298118183 0.0481986828470303 4190 2493.27272727273 2272 0.0026866679336846 907 1.10671900270465 1.21654317315129 1 4.97248727139904 4190 1570 2780 1143 1255 3347 4565 3476 907 1921 2272 2337 M14083 GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of plasma membrane organization. 113/137 Gene Ontology BP GO:1903729 0.448293696940057 0.497711899752347 2325 2153.72727272727 2272 0.0526315789473684 418 1.0734590605783 1.03459753754986 1 1.10145822945096 2323 766 2350 418 2977 2105 2272 3755 1165 2179 3381 2338 M14170 GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL.html The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. 15/17 Gene Ontology BP GO:0061756 0.103438980993692 0.137593361510478 780 2324.09090909091 2272 0.00987716310490481 776 1.50808112156194 1.800784971117 1 4.430771722903 776 3562 1467 3108 2272 1522 1260 3028 4619 2913 1038 2339 M10689 GO_PHOTOPERIODISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOPERIODISM.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. 36/67 Gene Ontology BP GO:0009648 0.0096237139698866 0.0200443782909052 2175 2107.27272727273 2274 0.000878733793416831 861 1.02192427895239 1.11827070699377 1 5.92201441445039 2171 1626 2991 2395 898 2976 1519 2274 2729 2740 861 2340 M12380 GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. 105/149 Gene Ontology BP GO:0002220 0.00306085443063151 0.00888480383445746 3085 2263.90909090909 2274 0.000278647391186627 34 0.716142230575513 -0.655747417767043 -1 5.01197579214149 3081 34 3917 896 592 1986 3370 1960 2274 4187 2606 2341 M14538 GO_CARDIOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. 110/192 Gene Ontology BP GO:0035051 0.0174816846759728 0.0319490490170077 1675 2095.45454545455 2274 0.0016020148440095 568 1.16646499931943 1.25920252453455 1 5.95368233050469 1673 2569 978 2908 2145 3311 2487 812 3325 2274 568 2342 M14825 GO_BODY_FLUID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_FLUID_SECRETION.html The controlled release of a fluid by a cell or tissue in an animal. 75/126 Gene Ontology BP GO:0007589 0.00322432516907038 0.00923816811064314 2525 2022.90909090909 2274 0.000293550951505015 439 1.43040944945447 1.56417885351032 1 9.93862870823698 2522 834 627 1048 3503 2994 2274 2853 1442 439 3716 2343 M11239 GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. 151/245 Gene Ontology BP GO:0022408 8.94791134010884e-05 0.000685978531070526 4180 2447.18181818182 2275 8.13479572107685e-06 219 1.25314420699553 -1.22471628820616 -1 13.5439563517789 4180 1426 514 755 2275 4050 4424 4532 1558 219 2986 2344 M14999 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. 45/62 Gene Ontology BP GO:2000649 0.333520216168578 0.385653470634292 2195 2287.27272727273 2275 0.0362139530177239 1486 1.03227626669972 1.03970991193628 1 1.4497706010062 2193 1580 1629 1844 3424 2896 2275 2821 1486 2601 2411 2345 M16589 GO_ZYMOGEN_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_ACTIVATION.html The proteolytic processing of an inactive enzyme to an active form. 132/192 Gene Ontology BP GO:0031638 0.00457098219657323 0.0118028746729496 2275 2239.18181818182 2275 0.000416409739244836 676 1.21695372149543 1.34547738456681 1 8.01121906711125 2275 1439 676 1293 3201 3893 2469 2547 1976 1621 3241 2346 M11279 GO_MONOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 63/87 Gene Ontology BP GO:0046365 0.0882122879366794 0.120579252576195 2735 2219.09090909091 2276 0.00836013875671124 577 1.11603551167091 -1.01883045231107 -1 3.49489484836679 2733 851 2345 1458 3191 3465 4488 1533 577 1493 2276 2347 M12788 GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. 22/24 Gene Ontology BP GO:1903671 0.0449805841189804 0.0681963694707123 4450 2699.81818181818 2278 0.0041752237738898 654 1.23846730790956 1.25450441655142 1 4.9274889864128 4448 2278 2230 654 1418 3593 4118 4235 973 1551 4200 2348 M13366 GO_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_GROWTH.html The increase in size or mass of an entire multicellular organism, as opposed to cell growth. 100/121 Gene Ontology BP GO:0035264 0.0144042403476463 0.0273898366724963 2080 1957.45454545455 2279 0.00131812945892735 791 1.08806578908703 1.15954607379442 1 5.80156653390636 2079 791 2879 1332 1017 2279 2526 2700 888 2760 2281 2349 M15310 GO_ENDOPLASMIC_RETICULUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. 44/47 Gene Ontology BP GO:0007029 0.0204526856801675 0.0361162605198555 1870 2351.81818181818 2280 0.0018768490756022 387 0.934511220245174 -0.834665150452089 -1 4.59754134565972 1868 3062 3916 4168 2776 630 387 2280 858 4108 1817 2350 M12859 GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT.html The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. 34/54 Gene Ontology BP GO:0048566 0.000165128656098395 0.0010837004750717 2615 2187.09090909091 2281 1.50128228824461e-05 379 1.58119558154084 1.56550329016626 1 16.018690406597 2614 952 379 857 4536 3711 2281 3612 1725 644 2747 2351 M15088 GO_REVERSE_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REVERSE_CHOLESTEROL_TRANSPORT.html The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. 14/24 Gene Ontology BP GO:0043691 0.073178529358163 0.102652908382132 2675 2448.54545454545 2282 0.00688476522962621 1601 1.50254936393911 -1.74610399854168 -1 5.06805876170421 2671 2852 1794 2052 1601 1738 3510 2401 3809 2224 2282 2352 M16773 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. 13/23 Gene Ontology BP GO:0014857 0.0155460868258454 0.0290973218023566 4370 2595.90909090909 2283 0.00142336736105338 636 1.11337943340583 -0.978906091537618 -1 5.83681239848742 4368 1194 2283 1866 1040 3503 4265 2123 636 2710 4567 2353 M11623 GO_CELL_PROLIFERATION_IN_FOREBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION_IN_FOREBRAIN.html The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. 25/46 Gene Ontology BP GO:0021846 0.0169736988686494 0.0312291897334226 4390 2432.36363636364 2285 0.00155509896127713 802 1.1416593424892 -1.27188732695137 -1 5.86547810282364 4389 1681 2095 1620 2285 4306 3705 802 1142 2338 2393 2354 M13833 GO_POSITIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEATH.html Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 721/961 Gene Ontology BP GO:0010942 0.0177783362158716 0.0323514268331836 2190 2360.18181818182 2286 0.00179221897732728 626 1.11938950396946 1.16504503479523 1 5.6921744657843 2187 2445 4452 2286 3549 1695 2488 2399 2046 626 1789 2355 M15770 GO_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_KILLING.html Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 42/141 Gene Ontology BP GO:0001906 0.502425139380881 0.552275968235114 2005 2234.90909090909 2287 0.0614840118837611 925 1.10027973539766 1.10366337241224 1 0.959293892786341 2005 925 1853 1222 4532 2287 2779 2754 1511 2416 2300 2356 M15948 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of lamellipodium organization. 40/46 Gene Ontology BP GO:1902745 0.0567984423066592 0.0832125793617397 3340 2509.90909090909 2287 0.00530182981230495 699 1.41604934627348 -1.21507041877766 -1 5.21713237627146 3336 3075 2248 1662 1498 4580 3925 2287 699 975 3324 2357 M12886 GO_REGULATION_OF_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCRINE_PROCESS.html Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 35/62 Gene Ontology BP GO:0044060 0.0249785553187238 0.0426018954950089 360 2257.54545454545 2289 0.00229697732648074 353 1.28248033757801 1.14416635818866 1 5.99892520932594 359 3768 1747 4034 4534 353 773 2300 4038 2289 638 2358 M10671 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. 62/82 Gene Ontology BP GO:0051148 0.148756955815436 0.18817268858086 1370 2434.63636363636 2290 0.014534932360355 1274 1.25231786070353 1.21451508821211 1 3.09540220218923 1370 2620 1615 3538 4528 2571 2290 3260 1985 1730 1274 2359 M10691 GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION.html A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. 9/20 Gene Ontology BP GO:0060231 0.0249290873985437 0.0425669885010729 3275 2255.81818181818 2290 0.00252132408513276 81 1.4650469352003 -1.94071749974926 -1 6.85619908481477 3274 1244 4255 1609 3577 2290 3210 982 81 2874 1418 2360 M15817 GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. 35/49 Gene Ontology BP GO:1901186 0.000179710429470684 0.00115496219382195 4235 2350.18181818182 2292 1.63386464614809e-05 186 1.16030835394852 -1.28460391593108 -1 11.642228472787 4235 1631 2159 1590 186 3673 2826 3240 984 2292 3036 2361 M11652 GO_BONE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_GROWTH.html The increase in size or mass of a bone that contributes to the shaping of that bone. 21/26 Gene Ontology BP GO:0098868 0.00899170885752249 0.0190001913324487 3090 2268.18181818182 2293 0.000820788264034494 601 1.26142093634013 1.26009876795813 1 7.41259249487108 3088 1711 1173 3050 1193 2293 3245 601 3649 1940 3007 2362 M14363 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 12/12 Gene Ontology BP GO:1900102 0.00382039326785391 0.0104198651086309 4655 2155.72727272727 2294 0.000347913065150422 20 1.11166677139841 -1.32098672033358 -1 7.52290864641393 4653 2376 3223 853 657 4493 2294 1321 20 2583 1240 2363 M11192 GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 61/108 Gene Ontology BP GO:0051055 0.0576702776433631 0.0841086808394315 995 2067.63636363636 2295 0.00538544999868974 621 1.01980599150487 0.918461823226212 1 3.73805501579092 991 1544 1576 2372 3972 621 846 2448 3243 2836 2295 2364 M12411 GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. 15/17 Gene Ontology BP GO:0050655 0.0208219770409001 0.0366709535092007 2155 2397.18181818182 2295 0.00191106352910405 1145 1.41937239215181 1.57779792311964 1 6.95633636719896 2153 2344 1621 2029 1145 3466 3989 2295 3544 1263 2520 2365 M10164 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 19/24 Gene Ontology BP GO:0051968 0.00110798557094821 0.0042501705371987 3760 2162.09090909091 2296 0.000100776725388037 405 1.62792220874921 -1.70086498731357 -1 13.1891066164365 3756 2296 585 2035 413 3307 3477 405 2504 883 4122 2366 M15000 GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 24/34 Gene Ontology BP GO:0050858 0.000636624601621079 0.00290413163857145 3070 2111.45454545455 2296 5.78917181288922e-05 140 1.15304611484863 -1.04838584882127 -1 9.99064454736 3070 1668 2296 140 325 3700 4056 3541 300 1358 2772 2367 M13753 GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 34/48 Gene Ontology BP GO:0070873 0.00396293295252568 0.0107268918139046 2270 2369.63636363636 2297 0.000360917233601176 288 0.998131045981152 1.04838661489056 1 6.7104583762003 2269 288 2297 2418 790 4326 4582 387 3991 2620 2098 2368 M11335 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. 27/45 Gene Ontology BP GO:0002475 0.0726295135721133 0.102204305669588 460 2637.36363636364 2298 0.00683129909386871 457 0.7385260764364 -0.744934993426437 -1 2.49040952053611 457 4469 3225 4030 1594 855 1721 2298 4637 3958 1767 2369 M11364 GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. 20/25 Gene Ontology BP GO:0050774 0.00814038717150972 0.0175601397816573 2900 2109.54545454545 2298 0.000742787727257316 205 1.05768217034633 0.952732533164081 1 6.33740445389981 2899 2293 3162 916 3393 761 205 3350 608 3320 2298 2370 M14763 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE.html Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. 18/43 Gene Ontology BP GO:0050884 0.0507453654685363 0.0755820056098269 3715 2811.45454545455 2301 0.00472319207848575 1461 1.13889136417013 -1.28549858130143 -1 4.35656247075411 3715 2301 2210 2027 1461 4142 3886 1885 2563 2137 4599 2371 M16793 GO_PROGESTERONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROGESTERONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. 14/26 Gene Ontology BP GO:0042448 5.14733838677594e-05 0.000463599074866202 2305 2341.63636363636 2301 4.67950802087221e-06 94 1.69766498791854 -1.48765351429552 -1 19.3398035092942 2301 1815 1562 580 94 3583 4598 3389 3727 2804 1305 2372 M12660 GO_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. 340/446 Gene Ontology BP GO:0097190 0.375168257280026 0.428067165552713 2305 2303.36363636364 2302 0.0418510948507061 1363 0.968106329938524 1.05296504022243 1 1.20899766488562 2302 1363 3306 1891 2725 1700 1938 2767 1964 2957 2424 2373 M14267 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. 15/21 Gene Ontology BP GO:0071636 0.0910229470383373 0.123488544181888 1015 2431.72727272727 2302 0.00863842069551021 937 1.10777235848954 1.1520654469079 1 3.42972440332754 1012 3205 2108 3310 4047 1510 937 1821 4126 2371 2302 2374 M10521 GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 30/37 Gene Ontology BP GO:0006221 0.20161514969794 0.245194796535419 1425 2503.09090909091 2303 0.020261424558647 739 0.809929360246788 -0.788361285381314 -1 1.67984524316045 1421 4111 3841 3553 2303 1417 2043 2017 739 3777 2312 2375 M13554 GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. 104/118 Gene Ontology BP GO:0048013 0.000343314041745005 0.00187445182457715 3460 2178.45454545455 2303 3.12152389308623e-05 43 1.17501909439411 1.21455672443991 1 10.9450970081684 3457 43 2303 371 247 4593 3868 3359 529 1157 4036 2376 M11092 GO_WHITE_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_WHITE_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. 18/20 Gene Ontology BP GO:0050872 0.0124148374685862 0.0243924242015775 695 2378.18181818182 2304 0.00113504129707281 271 1.0365389092785 1.14797634654319 1 5.70469922211923 695 2304 2381 3253 2277 826 271 4399 4386 3591 1777 2377 M12206 GO_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_FORMATION.html The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. 32/47 Gene Ontology BP GO:0048645 0.0118761823649715 0.0235549345883259 1325 2345.81818181818 2304 0.00108552562609233 210 1.26063017625188 -1.15242411574172 -1 7.00571023544979 1321 4104 2304 4077 4608 210 854 699 3079 2857 1691 2378 M12159 GO_MOTOR_NEURON_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_NEURON_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. 42/55 Gene Ontology BP GO:0008045 0.00258608749037992 0.00782159822858816 2305 2321.09090909091 2305 0.00023537567579442 609 1.41912895494191 1.48485301762733 1 10.2109141615461 2305 3057 609 2829 807 2095 1783 4472 2913 1104 3558 2379 M16083 GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI.html The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. 19/21 Gene Ontology BP GO:0000301 0.0798624643220041 0.110562346471373 2885 2156.81818181818 2305 0.0075380024747146 859 0.687506283923301 -0.56810358336327 -1 2.23738415304711 2883 1108 3608 2776 2305 1078 870 2616 859 4031 1591 2380 M10495 GO_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WOUND_HEALING.html Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 140/209 Gene Ontology BP GO:0061041 3.13102113821759e-14 5.48187926508039e-12 2370 2033.27272727273 2306 2.84638285292513e-15 19 1.62632520030115 1.28866947397801 1 62.6044961781755 2367 2024 19 945 1719 3352 2334 2306 2858 57 4385 2381 M16499 GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. 11/16 Gene Ontology BP GO:0002903 0.0107482230377149 0.0218288194074433 2310 2458.36363636364 2306 0.000981917825247614 799 0.683991290464041 0.8205824752893 1 3.87356524193816 2306 3253 2954 3586 925 799 927 2145 4271 3684 2192 2382 M14965 GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 38/40 Gene Ontology BP GO:0061028 0.0562137945666579 0.0824598947410653 1085 1920.54545454545 2307 0.00524579394896918 236 0.963050992076676 0.967952641981089 1 3.55773869719319 1084 236 2593 866 2307 1619 719 2582 3294 3214 2612 2383 M11040 GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. 26/31 Gene Ontology BP GO:0045606 0.0145943754035126 0.0276835013259455 2885 2336.54545454545 2308 0.00133564549926399 1021 1.309120451364 1.26443022287946 1 6.96166614688127 2884 2254 2648 2412 1021 2067 2295 3619 2308 2408 1786 2384 M11115 GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 186/228 Gene Ontology BP GO:0044272 0.000162619015110208 0.00107176526530849 4230 2118.63636363636 2308 1.47846397075829e-05 378 1.18614776686525 -1.1183341991166 -1 12.0334021314856 4230 705 378 924 882 2308 3786 3417 2814 424 3437 2385 M12265 GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. 40/72 Gene Ontology BP GO:1903792 0.0967950186843176 0.130245003452322 2310 2519.09090909091 2309 0.00921237194687743 1256 1.06028412747883 1.14107772692526 1 3.19837763444173 2309 1599 1256 2101 2208 2947 2341 3788 3854 1542 3765 2386 M16049 GO_STRIATED_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_ADAPTATION.html Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 27/42 Gene Ontology BP GO:0014888 0.0385660718269682 0.0605220681992861 1755 2440.81818181818 2309 0.00356901892672172 1146 1.13232164369239 -0.975545281498508 -1 4.7049731343422 1753 4138 2309 4230 2378 2441 1599 1146 3785 1619 1451 2387 M11868 GO_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH.html Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. 683/998 Gene Ontology BP GO:0040008 1.99942887355763e-06 3.17520223503878e-05 2015 2232.81818181818 2310 1.99943067253202e-07 121 1.22024765328101 1.21818045731221 1 18.7557784177943 2015 1897 4328 1244 3626 2500 2410 2425 1685 121 2310 2388 M13592 GO_HEART_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_FORMATION.html The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. 13/18 Gene Ontology BP GO:0060914 0.00708429631016944 0.0157718807326404 2310 2250.09090909091 2310 0.000646110188528503 542 1.91040971054069 -1.85560060862716 -1 11.7600239753791 2310 4553 2222 4331 2806 866 820 542 960 2700 2641 2389 M11596 GO_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BINDING.html Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. 14/21 Gene Ontology BP GO:1900120 0.000789949558746742 0.00336596638905548 2610 2151.18181818182 2311 7.18393951826662e-05 362 0.947633393641289 -0.611868146575565 -1 8.00127584109275 2610 2847 2311 2075 362 2519 1771 1637 3770 3358 403 2390 M14196 GO_SEGMENT_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENT_SPECIFICATION.html The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. 19/24 Gene Ontology BP GO:0007379 0.000344032206788929 0.00187445182457715 160 1736.36363636364 2312 3.12805470666752e-05 12 1.07564100129262 1.14588163741712 1 10.0185056726671 159 2312 2442 3697 3776 19 12 625 2798 3239 21 2391 M10241 GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 18/21 Gene Ontology BP GO:0051532 0.0100610335096711 0.0207459293651449 1515 2281.18181818182 2313 0.000918849214175356 418 0.8647101371715 0.947631989450263 1 4.9651542592999 1512 2313 3532 2469 908 3914 3300 1370 1768 3589 418 2392 M12662 GO_NEURAL_NUCLEUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_NUCLEUS_DEVELOPMENT.html The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. 100/153 Gene Ontology BP GO:0048857 0.00256655438820228 0.00778604077510738 3865 2092.54545454545 2313 0.000233595770009086 266 1.07201847673533 -1.12306947747902 -1 7.71803017521996 3861 2062 2582 2543 563 266 2648 2917 2313 2298 965 2393 M14403 GO_POTASSIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_IMPORT.html The directed movement of potassium ions into a cell or organelle. 19/35 Gene Ontology BP GO:0010107 0.000119193670624459 0.000859857595993189 1985 2067.63636363636 2315 1.08363753546545e-05 39 1.71857443727319 -1.71857443727319 -1 18.0017750245568 1985 2315 970 4116 3608 2399 2885 39 1036 2732 659 2394 M15102 GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 13/15 Gene Ontology BP GO:0009143 0.0310758327163358 0.0505893509901608 3355 2536.63636363636 2315 0.0028657883926638 568 1.99427490439098 2.04702866921271 1 8.82547821330755 3355 2869 1583 2315 2114 4500 4330 1038 568 1503 3728 2395 M11854 GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. 122/129 Gene Ontology BP GO:1901800 0.48830489638643 0.538408218693379 1845 2507.72727272727 2316 0.0590934793192752 914 0.970472375930965 1.03960826382932 1 0.881507090382795 1844 1444 3755 914 4082 2862 2283 2592 1516 3977 2316 2396 M12177 GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of leukocyte differentiation. 246/409 Gene Ontology BP GO:1902105 0.00633344480005506 0.0144600189669559 1350 2384.81818181818 2316 0.000577431962809889 634 1.23278371856625 1.27468488326821 1 7.74389924320615 1348 4291 720 3955 2905 2316 2144 2028 3271 634 2621 2397 M13483 GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. 359/405 Gene Ontology BP GO:0007264 0.349561319283822 0.402103539833775 1360 2124.54545454545 2318 0.0383461823846591 723 1.07287521004678 1.04701440238639 1 1.4406669648554 2434 1357 2620 723 2425 1822 2318 2978 1358 1409 3926 2398 M16821 GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS.html The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. 50/72 Gene Ontology BP GO:0048701 0.247809550778648 0.2955800665914 2320 2334.27272727273 2319 0.0255555776736487 1403 1.22952460013537 1.34334515450256 1 2.21444953306787 2319 3369 2000 2623 2814 1403 1620 2751 2478 2271 2029 2399 M12098 GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 18/26 Gene Ontology BP GO:0002068 0.00114382914889109 0.00434750735150862 2405 1975.81818181818 2320 0.000104038571314388 140 1.04127147937888 1.06077275926954 1 8.39732545662354 2403 391 2060 361 416 3394 2320 4435 140 2643 3171 2400 M12920 GO_APOPTOTIC_NUCLEAR_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_NUCLEAR_CHANGES.html Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. 26/32 Gene Ontology BP GO:0030262 0.047713692163652 0.0716398224064126 1560 2465.81818181818 2320 0.00443464197845972 665 0.786913638327801 -0.778300880429934 -1 3.06944828236605 1557 4465 3686 3615 1539 2320 2664 1632 1373 3608 665 2401 M14888 GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. 45/59 Gene Ontology BP GO:0032881 0.000565569635625144 0.00266086502989261 1515 2365.27272727273 2321 5.14286439073897e-05 311 1.03140118170025 1.09028027366714 1 9.06949560234068 1514 2663 2018 3525 311 3224 3537 805 3823 2277 2321 2402 M16303 GO_PENTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. 13/18 Gene Ontology BP GO:0019321 0.00193957940213818 0.00639120213122408 2700 1870.63636363636 2321 0.000176481045571691 78 1.44476239966396 -1.64592510766504 -1 10.8288084412334 2697 491 2321 481 3145 2678 3797 266 78 2108 2515 2403 M13703 GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 33/45 Gene Ontology BP GO:0098815 0.00472180736868732 0.0120645682384378 2475 2176.81818181818 2322 0.000430179293386806 419 1.48083579432181 -1.66108659143433 -1 9.70245060090395 2471 4425 1688 1113 2800 2322 3777 419 2344 2164 422 2404 M13155 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. 50/55 Gene Ontology BP GO:0034502 0.0112368152504602 0.0226341564330699 1765 2533.09090909091 2324 0.00102678388026953 677 1.50544262640576 -1.72719456053108 -1 8.45741326137524 1765 3368 3169 3092 4212 2085 2324 677 2062 3460 1650 2405 M14546 GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of activated T cell proliferation. 16/28 Gene Ontology BP GO:0042104 0.0216169392414868 0.0376858817124909 1630 2236.63636363636 2324 0.00198475575914051 381 1.20499497500758 -1.00064756528083 -1 5.855216858112 1629 3872 2324 3024 3165 574 731 2060 4393 2450 381 2406 M14734 GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 17/18 Gene Ontology BP GO:0009219 0.052070351830351 0.0772094796260749 875 2117.90909090909 2324 0.00484956545285691 678 0.771924595093137 -0.668918441934121 -1 2.92496310380806 871 2324 3564 1604 2744 926 678 2934 1460 3538 2654 2407 M15198 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin polymerization. 76/97 Gene Ontology BP GO:0030838 0.074215720950028 0.103888612990518 4060 2840.54545454545 2325 0.00698585119809808 1514 1.123048373425 0.931775615141655 1 3.76536554795003 4056 1514 2325 1640 1608 3944 3913 4445 2283 1938 3580 2408 M11415 GO_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 561/883 Gene Ontology BP GO:0001775 0.0028783658589813 0.00846588896450062 1840 2456.54545454545 2326 0.000288210091516558 426 1.17761845580934 1.12223742998223 1 8.33297416435286 1838 1908 4300 2032 2484 2326 2155 2957 2724 426 3872 2409 M12698 GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 291/381 Gene Ontology BP GO:0046822 0.0574041052203796 0.0838096333826251 785 2379.27272727273 2326 0.00535991319499518 758 1.00103333995596 1.08473777313207 1 3.6743425570084 784 3962 3494 3671 3933 875 1039 1386 2326 3944 758 2410 M13625 GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. 104/159 Gene Ontology BP GO:0046887 0.110919458136886 0.145958212305128 1590 2633.90909090909 2326 0.0106310367417688 1291 1.32364627104346 1.33479449096935 1 3.77160176319724 1588 3671 1291 3596 4517 2980 1931 2326 3779 1772 1522 2411 M10286 GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-4 production. 34/68 Gene Ontology BP GO:0032673 0.0290974753545814 0.0481303067276457 960 2580.90909090909 2327 0.00268087296048934 959 1.17169924984708 -1.03940197124276 -1 5.26753935511061 959 4427 2747 4365 1253 1867 2327 1450 3964 2973 2058 2412 M11421 GO_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXON_GUIDANCE.html Any process that modulates the frequency, rate or extent of axon guidance. 37/47 Gene Ontology BP GO:1902667 0.00436674586453862 0.011459937116581 4165 2525 2328 0.000397767046631425 666 1.60945626474174 1.67255672839495 1 10.6689709234846 4161 2694 666 2017 1615 2328 3912 2138 2569 1040 4635 2413 M12805 GO_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. 97/169 Gene Ontology BP GO:0030216 7.99088644206567e-05 0.000628067476603573 2330 2076.72727272727 2328 7.26470609408192e-06 343 1.51542946623131 -1.85455114931816 -1 16.5794224803251 2328 1473 343 3210 3666 1724 2873 2514 3225 762 726 2414 M15651 GO_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a T cell. 30/50 Gene Ontology BP GO:0002456 0.0317899795851837 0.0513963776962682 1110 2317.09090909091 2329 0.00293262343425516 490 1.19123464367266 1.04150749230395 1 5.2394108073775 1108 3780 2293 3304 3340 2329 556 2531 3850 1907 490 2415 M16198 GO_ENDOTHELIAL_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 16/17 Gene Ontology BP GO:0061154 5.62231143781541e-05 0.000490818294937244 3625 1917.81818181818 2329 5.11132284229879e-06 87 1.30849092044861 1.32425227709657 1 14.7930380886672 3621 1770 2329 179 99 2805 2757 2561 87 1402 3486 2416 M11312 GO_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 45/50 Gene Ontology BP GO:0010762 0.335920354181586 0.387946738150141 4505 2570.27272727273 2330 0.0365299981731523 1562 1.20887187416411 1.37359086500304 1 1.68897066452303 4505 2165 2520 1680 2330 1773 3037 2750 1572 1562 4379 2417 M13574 GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 73/111 Gene Ontology BP GO:0051588 0.120206073411416 0.156597530166665 2445 2258.72727272727 2330 0.0115749949356078 1293 1.07983801638754 -0.967628443574868 -1 2.96211839641549 2441 2603 2091 2851 2012 1293 1815 1724 3099 2330 2587 2418 M11051 GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type peptidase activity. 4/15 Gene Ontology BP GO:1902571 0.000347998694974969 0.00188809260014363 830 2208 2331 3.48053203380226e-05 91 0.568766130791798 0.568766130791798 1 5.28633190732744 826 2929 4276 3260 2331 1094 317 91 4544 4462 158 2419 M12577 GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. 27/40 Gene Ontology BP GO:0000027 0.000396442502795705 0.00205457605131779 690 2282.27272727273 2331 3.60467236557961e-05 230 0.732895838174163 0.617610245744809 1 6.72293600971682 690 3480 3774 3620 270 911 230 1347 4280 4172 2331 2420 M11683 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. 4/12 Gene Ontology BP GO:1902572 0.000331212755968448 0.0018325005392642 830 2214.18181818182 2332 3.31262132176687e-05 85 0.568766130791798 0.568766130791798 1 5.31157097840609 827 2930 4320 3261 2332 1095 318 85 4545 4484 159 2421 M12446 GO_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that modulates the activity of a transporter. 198/288 Gene Ontology BP GO:0032409 0.000214004566120948 0.00132945693746431 2050 2244.36363636364 2332 1.94568532916677e-05 397 1.13603967593119 1.02279566549054 1 11.161158600661 2049 2522 397 2332 2699 1688 2086 4356 3062 759 2738 2422 M13645 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. 29/34 Gene Ontology BP GO:1900078 0.0964380562072553 0.129839778799872 2885 2246.63636363636 2332 0.00917678046042786 316 0.883783004533477 -0.706554531693159 -1 2.66827108307887 2882 316 2332 1676 1724 1664 1576 2601 4181 3052 2709 2423 M14513 GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organonitrogen compound. 1625/2218 Gene Ontology BP GO:1901564 0.169602741985978 0.210836643991653 2025 2105.81818181818 2332 0.0184134687089613 566 1.08309979331289 -0.998112778142651 -1 2.49280625059019 2023 566 4498 679 2579 1214 2332 2872 1395 2382 2624 2424 M16015 GO_AMINOGLYCAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 58/79 Gene Ontology BP GO:0006026 0.00619075195450232 0.0141829487170356 4575 2652.27272727273 2332 0.000564385594147897 718 1.20743908130422 -0.941129610666877 -1 7.61916048267483 4571 858 718 1445 4613 1880 2969 3510 2332 1794 4485 2425 M13174 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. 4/12 Gene Ontology BP GO:1900004 0.000363807700138231 0.00195022722205437 830 2228.90909090909 2333 3.6386727408442e-05 93 0.568766130791798 0.568766130791798 1 5.25898735032727 828 2931 4414 3262 2333 1096 319 93 4546 4536 160 2426 M14576 GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of adherens junction organization. 42/47 Gene Ontology BP GO:1903393 0.0401868154560793 0.062433807117575 130 2119.09090909091 2333 0.00372183971143489 128 1.12119101963246 1.02866705068336 1 4.60684616260587 128 3395 1194 3450 2537 1080 643 2333 4240 3089 1221 2427 M11500 GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 48/76 Gene Ontology BP GO:0002755 0.0433371688305107 0.0663994691573394 1410 2585.36363636364 2334 0.0040195605925699 1202 1.25223929564933 1.13559071276003 1 5.03205135025937 1406 4054 2161 4231 3090 2334 1209 1202 3547 3081 2124 2428 M15052 GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. 4/15 Gene Ontology BP GO:1900003 0.00032927288851816 0.00182393660747024 830 2245 2334 3.29321687980884e-05 84 0.568766130791798 0.568766130791798 1 5.31552697885533 829 2932 4534 3263 2334 1097 320 84 4547 4594 161 2429 M15426 GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 1709/2257 Gene Ontology BP GO:0031399 0.0129996494468653 0.0253297189599097 2120 2302.09090909091 2336 0.00130763274010518 579 1.11816206512127 1.17169689879971 1 6.09215820494422 2117 1255 4556 706 3009 2547 2336 2780 2155 579 3283 2430 M16467 GO_DERMATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. 12/14 Gene Ontology BP GO:0030205 0.0842451870545395 0.115837132199992 1925 2442 2336 0.00796868232947696 896 1.41937239215181 1.57779792311964 1 4.53225878118152 1922 2374 1290 1998 2591 3849 4315 1882 3409 896 2336 2431 M12377 GO_POSITIVE_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_RATE.html Any process that activates or increases the frequency or rate of heart contraction. 25/35 Gene Ontology BP GO:0010460 0.0050549847824836 0.012713969833998 2305 2401.81818181818 2337 0.000460603384078461 690 1.69448296379002 1.68706554860002 1 10.9718962907184 2304 3477 690 3717 1328 3564 3025 1732 2337 1097 3149 2432 M13949 GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY.html The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. 16/43 Gene Ontology BP GO:0060397 4.0817743314606e-05 0.000381375420969602 2340 2047.72727272727 2338 3.71077278609836e-06 65 0.972614201406648 -1.10465695996816 -1 11.35742248403 2338 1132 2861 662 88 2550 3985 3991 65 2998 1855 2433 M16719 GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 46/72 Gene Ontology BP GO:0060119 0.443066065022854 0.493084525365065 2555 2416 2338 0.0518190104516206 1588 1.16122360086602 1.18798982244098 1 1.20848927828108 2551 1588 2338 2619 2779 2246 2257 3178 1885 2966 2169 2434 M12396 GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. 86/132 Gene Ontology BP GO:0040014 0.0543455673023059 0.0800856191343937 4090 2452.63636363636 2339 0.00506694403786585 1128 1.19100580611569 -1.257459616941 -1 4.4540480361579 4086 1482 2339 1128 1486 4008 4207 2797 1152 2418 1876 2435 M15104 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION.html The process in which epiblast cells acquire specialized features of neuroepithelial cells. 74/104 Gene Ontology BP GO:0060563 0.00663418665224035 0.0149392825714644 2340 2026.63636363636 2339 0.00060493428836201 608 1.49779712626291 1.40863440318077 1 9.33839303265158 2339 2602 728 2661 2418 882 941 4318 2745 608 2051 2436 M16165 GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. 42/59 Gene Ontology BP GO:0046622 0.342506357423649 0.394866719794906 3795 2650.27272727273 2339 0.0374025938375381 212 1.19989318697977 1.29499005436645 1 1.64484716802215 3793 212 1639 1156 2339 4498 4650 3915 736 1698 4517 2437 M12415 GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. 43/50 Gene Ontology BP GO:0048745 0.00847368348715428 0.0181575755508341 155 2210.81818181818 2342 0.000773318040238626 154 1.34697250903236 1.32601718569887 1 8.00677298386577 154 3403 766 3456 2565 1795 1855 2342 4225 2497 1261 2438 M16925 GO_DIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 214/346 Gene Ontology BP GO:0072511 0.00172873965771251 0.00590589253108393 2335 2340 2342 0.000157281780149819 553 1.10922552095301 -1.0496301872743 -1 8.44147763166157 2334 689 553 2738 3554 2342 2140 3963 3021 1411 2995 2439 M12260 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. 176/247 Gene Ontology BP GO:1900182 0.0405948124528515 0.0628787158266039 1290 2361.81818181818 2343 0.00376034692627693 1169 1.07419356753185 1.17418159279927 1 4.40196626719939 1288 3640 3151 3681 2466 2343 1578 1169 2195 2759 1710 2440 M12262 GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 26/62 Gene Ontology BP GO:0045072 0.00282930083025551 0.00835856302424057 2190 2385.54545454545 2343 0.000257540545953957 316 1.12909894493047 1.12498040270072 1 8.01059465378211 2186 3470 1918 3381 670 3761 2343 316 3804 2411 1981 2441 M14618 GO_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 25/33 Gene Ontology BP GO:0072215 0.0258881533522767 0.043898534091889 1695 2397 2343 0.00238162756359033 423 1.06346144869164 0.989985833805243 1 4.9252786765102 1693 2753 1780 3063 3702 2089 1981 3387 3153 2343 423 2442 M12346 GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. 118/127 Gene Ontology BP GO:0006892 0.0705267306212258 0.0996843492043024 2345 2259.90909090909 2344 0.0066267844935648 544 0.799514573253424 -0.825861477675102 -1 2.72658867339159 2344 1445 4126 1625 2921 1249 2751 2706 544 4300 848 2443 M10038 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION.html The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. 20/46 Gene Ontology BP GO:0050908 0.40220920514419 0.453912061978151 1565 2145.81818181818 2347 0.0456969913884218 385 1.13555948724003 1.19210067500418 1 1.32111646466118 1565 385 1698 508 4125 2470 2646 4537 941 2347 2382 2444 M10078 GO_MITOTIC_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CYTOKINESIS.html A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. 44/56 Gene Ontology BP GO:0000281 0.000927086256522586 0.00375760657804843 275 2136.09090909091 2347 8.43161058134862e-05 36 0.744189137042869 -0.769294834440065 -1 6.15959591816033 275 3381 3834 3984 2347 151 265 949 3968 4307 36 2445 M16546 GO_RESPONSE_TO_MANGANESE_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MANGANESE_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. 25/30 Gene Ontology BP GO:0010042 0.00085497534086247 0.00356150426233937 845 1937.27272727273 2347 7.77552533342158e-05 209 1.10535619927272 1.00682766042056 1 9.24209310638496 843 3466 2347 3306 375 257 209 2839 3768 2767 1133 2446 M16838 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 29/39 Gene Ontology BP GO:0045922 8.948828032663e-05 0.000685978531070526 4650 2321.27272727273 2347 8.13562914574266e-06 132 0.876367964396718 -1.03188738519712 -1 9.46856070180351 4647 299 2608 146 132 3667 4494 2044 2347 3429 1721 2447 M12028 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. 65/82 Gene Ontology BP GO:1904377 0.595119338036411 0.641735870193145 3255 2487.81818181818 2348 0.0789091721214099 853 1.10974295694967 0.943214036859903 1 0.720256835294752 3255 853 2039 888 4412 2456 2348 3374 1045 2196 4500 2448 M14531 GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. 14/25 Gene Ontology BP GO:0035590 0.011853992320224 0.0235350736247133 2140 2404.27272727273 2348 0.00108348634074703 698 1.37299352696141 1.39965145056043 1 7.6328180646229 2140 2348 1166 2761 2169 3293 2754 698 3983 2221 2914 2449 M14254 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. 65/82 Gene Ontology BP GO:1903078 0.595119338036411 0.641735870193145 3260 2505.18181818182 2349 0.0789091721214099 854 1.10974295694967 0.943214036859903 1 0.720256835294752 3256 854 2040 889 4413 2457 2349 3554 1046 2198 4501 2450 M10365 GO_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_TISSUE_DEVELOPMENT.html The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. 290/442 Gene Ontology BP GO:0060537 5.79301215210523e-08 1.54027917392832e-06 1080 1903.72727272727 2350 5.26637482240555e-09 130 1.22720591127029 1.31189571557684 1 24.3767310610319 1078 2486 130 2350 4144 2720 2382 1900 3197 406 148 2451 M12044 GO_HISTONE_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_EXCHANGE.html The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. 45/164 Gene Ontology BP GO:0043486 0.163126363360292 0.203984673129654 2245 2580 2350 0.0160589479225461 1402 0.974606358255083 -1.0971119092771 -1 2.28984654268915 2244 2166 3354 3218 1975 2055 2350 3423 1402 3248 2945 2452 M12064 GO_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION.html The controlled release of a substance by a cell or a tissue. 575/906 Gene Ontology BP GO:0046903 4.83152148274766e-05 0.000439942650865457 2355 2527.27272727273 2351 4.83162653216142e-06 198 1.2160218808085 1.21479046033172 1 13.9444678748076 2351 1905 4342 972 1990 2516 2298 4525 2871 198 3832 2453 M15876 GO_PLATELET_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DEGRANULATION.html The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. 113/171 Gene Ontology BP GO:0002576 7.20102793364068e-05 0.000585775926140386 1105 2499.45454545455 2351 6.54660331644879e-06 330 1.25723874368926 1.2175549420944 1 13.8830271220035 1101 3669 330 4521 2205 2351 1189 4344 4063 1124 2597 2454 M12821 GO_REGULATION_OF_STEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of steroid hormone secretion. 15/30 Gene Ontology BP GO:2000831 0.258023588555876 0.306897688535401 2620 2633.81818181818 2353 0.0267659796976683 1427 1.50320615160445 -1.59302644232436 -1 2.62587340897214 2619 2353 1984 3526 3126 1427 2076 4602 1446 1763 4050 2455 M13218 GO_GALACTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. 16/16 Gene Ontology BP GO:0006012 0.00386006735329781 0.010503446429763 4105 2193.09090909091 2354 0.000351532438059498 290 0.91928717922611 -0.781667264277209 -1 6.20828044358818 4105 424 2354 479 660 3308 4397 2677 290 1895 3535 2456 M14049 GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. 1524/2035 Gene Ontology BP GO:0051247 0.00104489373440696 0.00410174851746683 2315 2265.72727272727 2354 0.000104538537109889 77 1.13634875143732 1.20359868179388 1 9.26323088149249 2311 568 4471 77 3394 3248 2580 2135 2354 355 3430 2457 M11381 GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 17/20 Gene Ontology BP GO:0090335 0.000267087834324024 0.00156125589586644 3205 2303.09090909091 2355 2.42836604773165e-05 217 0.962126214778357 -0.932132597603733 -1 9.22128889815854 3202 1757 2355 2424 217 1902 1356 2918 3961 3071 2171 2458 M13005 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 188/299 Gene Ontology BP GO:0051924 5.06996308214562e-05 0.000458959887572443 2360 2204.09090909091 2356 4.60916356788032e-06 314 1.1744400193318 1.12563231816918 1 13.393475520896 2356 1991 314 1825 3213 3121 3166 3415 2475 511 1858 2459 M16634 GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 320/389 Gene Ontology BP GO:0010976 0.0336231878295583 0.0539664342776595 2485 2230.72727272727 2357 0.00310439374823185 829 1.15878145443112 1.18102634963871 1 5.01242574702367 1851 2481 1000 2357 4109 1962 2552 3703 2482 829 1212 2460 M16943 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. 83/143 Gene Ontology BP GO:0002705 0.00722400947694957 0.0160522044394682 1295 2426.72727272727 2357 0.000658894559311335 545 1.03995272955356 1.10601580031764 1 6.36963704938215 1292 3681 2664 3614 2357 1631 1485 545 3857 3253 2315 2461 M10669 GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epidermis development. 72/90 Gene Ontology BP GO:0045682 0.0483915799513487 0.0725639772844426 2360 2229.54545454545 2358 0.00449908975321182 650 1.37015452446942 1.14511464458376 1 5.3262736746992 2358 3341 1678 3529 2861 967 650 2630 2387 2028 2096 2462 M11530 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 28/35 Gene Ontology BP GO:0043243 0.063506434323775 0.0910898393676095 2395 2155.36363636364 2358 0.00594703033003974 1017 0.984336753598662 1.06520392249354 1 3.49113252627246 2391 1017 2826 2358 3070 2298 2437 1388 3043 1333 1548 2463 M14779 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. 20/46 Gene Ontology BP GO:0050962 0.40220920514419 0.453912061978151 1570 2147.90909090909 2359 0.0456969913884218 386 1.13555948724003 1.19210067500418 1 1.32111646466118 1566 386 1699 509 4126 2471 2647 4539 942 2359 2383 2464 M14724 GO_UBIQUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. 13/13 Gene Ontology BP GO:0006743 0.0510732367458506 0.0759487921311739 1215 2330.09090909091 2360 0.00475444855642952 1211 0.647469660919907 -0.539379369013107 -1 2.46748869467181 1211 2360 3543 3059 1464 1222 1924 2508 2476 3814 2050 2465 M15279 GO_RESPONSE_TO_HYDROPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROPEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. 20/26 Gene Ontology BP GO:0033194 0.0041480774367812 0.0110670896292104 3680 2291.36363636364 2360 0.000377810845647996 193 1.39423264942841 -1.68614444311672 -1 9.31305449864241 3678 1092 1953 193 678 3211 2665 3857 940 2360 4578 2466 M16109 GO_FEMALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. 20/23 Gene Ontology BP GO:0030540 0.0251218223626678 0.0427861784236798 4445 2297.09090909091 2361 0.0023103054725387 1078 1.26654918017868 1.04941761227671 1 5.91615582582952 4444 1078 1503 1081 1203 2745 3561 2520 1570 2361 3202 2467 M15739 GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 28/55 Gene Ontology BP GO:0010866 0.35686385351563 0.409592380465769 3235 2255.09090909091 2362 0.0393327341209218 319 1.38352939445987 -1.08853975335554 -1 1.82299595734024 3235 319 1657 536 2362 4336 3733 3497 406 2174 2551 2468 M11389 GO_RELAXATION_OF_CARDIAC_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_CARDIAC_MUSCLE.html The process in which the extent of cardiac muscle contraction is reduced. 21/30 Gene Ontology BP GO:0055119 0.213333842505598 0.257829186799623 3655 2516.27272727273 2366 0.0215775566859756 1074 0.928711242713628 -0.971312819362058 -1 1.8584844008489 3651 1074 1689 2366 2897 2291 3982 2046 3321 2427 1935 2469 M13627 GO_ORGAN_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_INDUCTION.html The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. 12/25 Gene Ontology BP GO:0001759 3.23094227302077e-05 0.000323302675190659 3445 2098 2366 2.93726338540156e-06 73 1.36695048583013 -1.35691961685867 -1 16.3017891459231 3444 2366 1660 1405 73 3348 2822 2845 662 1962 2491 2470 M14369 GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. 16/19 Gene Ontology BP GO:0036499 0.0242287216514419 0.0415081891915167 885 2351.36363636364 2366 0.00222724926285522 884 1.29241550626267 1.0410747414238 1 6.09539034006926 884 3896 2366 2918 1188 988 1447 4123 3417 2449 2189 2471 M10149 GO_LABYRINTHINE_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_DEVELOPMENT.html The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. 48/64 Gene Ontology BP GO:0060711 0.00577426225782821 0.0134540021460564 4310 2251.54545454545 2368 0.000526315789473684 170 1.13620894310504 -0.927466299347811 -1 7.25807296378191 4306 170 1901 207 2368 2832 3963 3153 339 1790 3738 2472 M13605 GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 17/20 Gene Ontology BP GO:0036109 0.000110993220105132 0.00081330937503808 3465 2433.18181818182 2368 1.00908018428274e-05 145 1.1038287819192 1.45408872060521 1 11.6498234696089 3464 2815 2368 2318 145 3188 2169 2229 2236 2554 3279 2473 M14432 GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is increased. 29/50 Gene Ontology BP GO:0045777 0.00427703960138099 0.0112881822264468 2530 2289.81818181818 2368 0.00038957975766054 479 1.48481860585268 1.27646611290865 1 9.8752239582778 2529 2236 662 4117 4076 3322 2368 728 3598 1073 479 2474 M11009 GO_SERTOLI_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. 17/21 Gene Ontology BP GO:0060009 0.000691965418214512 0.00306639532471631 4180 2245.18181818182 2370 6.29257416182138e-05 338 1.06425862431571 -1.01363713269743 -1 9.13460328118844 4177 1129 2370 1563 338 3487 3471 446 1123 3068 3525 2475 M12117 GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. 29/35 Gene Ontology BP GO:0060765 0.144981661808361 0.183814624630601 2375 2090.09090909091 2371 0.014138406213006 293 0.942095389347047 1.26262826114015 1 2.35875037363329 2371 293 3062 449 1912 3164 3356 2246 304 3426 2408 2476 M14313 GO_ACIDIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSPORT.html The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/26 Gene Ontology BP GO:0015800 0.000604291469163304 0.00279222264748446 4510 2411.81818181818 2373 5.49506835051991e-05 318 1.03117461059702 -0.793638328043718 -1 8.99372143012373 4506 1156 2120 1755 318 2520 2426 4151 1479 2373 3726 2477 M16068 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. 17/30 Gene Ontology BP GO:1901380 0.128397475950107 0.165494032021011 2725 2301.72727272727 2374 0.0124151769083194 1224 1.20279739820459 1.07338656357157 1 3.20193945149021 2725 2808 1602 2374 1851 2554 1224 2215 2522 2044 3400 2478 M13511 GO_NEURONAL_ION_CHANNEL_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ION_CHANNEL_CLUSTERING.html The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. 16/29 Gene Ontology BP GO:0045161 0.0530548098268765 0.0783944204904593 3225 2197.09090909091 2375 0.00494356423714674 1139 1.2354365004033 -1.36853012963222 -1 4.65975778414614 3223 1139 1748 1303 2375 3279 3028 1310 2428 2997 1338 2479 M11035 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. 23/36 Gene Ontology BP GO:0045686 0.115627166053566 0.151297301363117 1400 2427.90909090909 2376 0.0111084357874503 933 1.30446299648068 1.00632011188816 1 3.6472002578233 1399 4485 2426 4268 3236 933 1205 2376 2295 2603 1481 2480 M12366 GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. 3/14 Gene Ontology BP GO:0021520 7.50752537727769e-05 0.000601248116703495 2380 2169.90909090909 2376 7.50777902255581e-06 28 1.33522971027497 -1.33522971027497 -1 14.6932150566078 2376 3271 4364 3368 1536 2466 2166 28 818 2805 671 2481 M13311 GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 20/23 Gene Ontology BP GO:0035729 0.0772253582743783 0.107422897474046 895 2558.18181818182 2376 0.00727975805555465 737 0.942492361243669 0.795151861476706 1 3.1114646458841 894 4516 2970 4598 2376 737 999 1981 4432 2826 1811 2482 M13705 GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 20/23 Gene Ontology BP GO:0035728 0.0772253582743783 0.107422897474046 895 2550.90909090909 2377 0.00727975805555465 738 0.942492361243669 0.795151861476706 1 3.1114646458841 895 4517 2971 4599 2377 738 1000 1890 4433 2828 1812 2483 M16030 GO_MATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING_BEHAVIOR.html The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. 15/27 Gene Ontology BP GO:0007617 6.44179913890446e-05 0.00053812731406324 4125 2000.72727272727 2377 5.85635251667891e-06 111 1.35192690059928 -1.17446274806518 -1 15.0997323595915 4125 486 2406 847 111 2453 3092 1452 2790 2377 1869 2484 M11578 GO_ADULT_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_LOCOMOTORY_BEHAVIOR.html Locomotory behavior in a fully developed and mature organism. 85/161 Gene Ontology BP GO:0008344 0.0063439875822175 0.0144769858852663 435 1939.27272727273 2378 0.000578395954126489 103 1.12949307827891 1.07494531127518 1 7.09220488292625 435 3004 2378 2916 1620 103 229 4566 2452 2862 767 2485 M15437 GO_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. 120/149 Gene Ontology BP GO:0050673 1.48973663872713e-05 0.000177737040512753 2100 2153.54545454545 2378 1.35431520601761e-06 269 1.41692844860842 1.28763230628184 1 18.1569272727287 2099 764 269 878 3796 4536 2432 3145 3051 341 2378 2486 M16592 GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species. 15/27 Gene Ontology BP GO:0044705 6.44179913890446e-05 0.00053812731406324 4130 2060.36363636364 2378 5.85635251667891e-06 112 1.35192690059928 -1.17446274806518 -1 15.0997323595915 4126 487 2407 848 112 2454 3093 2098 2791 2378 1870 2487 M13046 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 32/36 Gene Ontology BP GO:0006294 0.00490612965069551 0.0124269032469713 1290 2656.72727272727 2379 0.000447009535442726 729 0.604546410029203 -0.618266565074513 -1 3.92812211412365 1289 3776 3989 3649 729 753 1685 2281 4163 4531 2379 2488 M11220 GO_THYMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMUS_DEVELOPMENT.html The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. 57/80 Gene Ontology BP GO:0048538 0.296311637571697 0.347727124746811 1710 2445.63636363636 2380 0.0314423223774645 1238 1.0135391777742 1.15664997261336 1 1.57905440044675 1706 3720 3175 2237 2391 2274 1680 3009 1238 2380 3092 2489 M16214 GO_RUFFLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. 27/42 Gene Ontology BP GO:0031529 0.12439007219266 0.161311874557538 3800 2190.27272727273 2380 0.0120032497538992 334 0.986304410119597 0.96886770947807 1 2.66118373354507 3799 334 2922 881 1833 1786 2493 2380 2999 2507 2159 2490 M16898 GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS.html A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. 52/66 Gene Ontology BP GO:0061640 0.00114457264250979 0.00434750735150862 355 1990.18181818182 2380 0.00010410623202652 42 0.758110608188103 -0.820210198697742 -1 6.1108772930975 354 2644 3844 3546 2380 61 192 922 3638 4269 42 2491 M11055 GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. 25/34 Gene Ontology BP GO:0002042 0.142841963594205 0.181378927630538 1700 2691.81818181818 2383 0.0139143758671544 1367 1.26453842470597 1.22124838487299 1 3.19475579775306 1697 4149 1367 3436 2166 2383 1528 3428 4212 2336 2908 2492 M12544 GO_IN_UTERO_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IN_UTERO_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. 334/428 Gene Ontology BP GO:0001701 0.528067318531503 0.577461159371818 2385 2301 2383 0.0659874061384058 638 1.09136859785734 1.13512019123019 1 0.879174905999256 2383 638 2743 1859 3365 2698 2196 2966 1236 2090 3137 2493 M15624 GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. 551/689 Gene Ontology BP GO:0071900 0.0332462779565189 0.053472150477595 1220 2110 2383 0.00337544019416211 464 1.15222117132217 1.17505516832162 1 4.99973028317095 1216 2454 4564 3411 3040 464 1080 2383 2529 868 1201 2494 M11981 GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. 896/1152 Gene Ontology BP GO:0051345 0.0107847625828506 0.0218751091098535 2060 2284.54545454545 2384 0.0010837462899117 551 1.11176823743387 1.11755609159364 1 6.29931444344621 2056 1296 4337 702 3264 1983 2571 2835 2384 551 3151 2495 M10613 GO_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 187/221 Gene Ontology BP GO:0051783 0.159228216068067 0.199916052176124 2370 2726.45454545455 2385 0.015643174252063 1873 1.03242437036681 -0.998451392067703 -1 2.45720838262692 2366 1994 3499 2915 4334 2227 2895 1873 1924 3579 2385 2496 M14733 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 79/93 Gene Ontology BP GO:0090003 0.345955566747665 0.398251175674637 2685 2332.09090909091 2386 0.0378627633256802 817 1.04540703209539 0.923005060703466 1 1.41845253130348 2681 817 2253 873 2343 2398 2597 3753 1355 2386 4197 2497 M16453 GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the N-terminal amino acid residue in a protein. 22/27 Gene Ontology BP GO:0031365 0.0232262658902103 0.0400414283761202 2390 2475.72727272727 2386 0.00213410557701612 729 0.538545296354714 0.549182170637545 1 2.56247775613512 2386 1057 3981 1929 1176 2716 2133 3202 729 4639 3285 2498 M11191 GO_POSITIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_GROWTH.html Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 35/45 Gene Ontology BP GO:0060421 0.00577426225782821 0.0134540021460564 3440 2421.18181818182 2388 0.000526315789473684 238 1.21200762873807 1.30323995314278 1 7.74298431362392 3440 249 1624 238 2388 4158 3970 4124 511 1913 4018 2499 M12394 GO_PROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. 1185/1551 Gene Ontology BP GO:0070271 0.115611308004483 0.151297301363117 2390 2561.90909090909 2388 0.0122106985469546 984 1.03681737697002 -1.07345150940038 -1 2.89669142018544 2388 1880 4367 1736 2943 984 2412 3816 2102 3840 1713 2500 M15475 GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the C-terminal amino acid residue in a protein. 11/16 Gene Ontology BP GO:0018410 7.11288027924618e-05 0.000580635648058465 2640 2411.45454545455 2389 6.46646387103379e-06 121 0.678100613789834 -0.584770447482179 -1 7.49187160230177 2636 2389 3352 2589 121 1677 2224 2194 4144 3681 1519 2501 M16814 GO_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex. 1185/1551 Gene Ontology BP GO:0006461 0.115611308004483 0.151297301363117 2390 2588.45454545455 2389 0.0122106985469546 985 1.03681737697002 -1.07345150940038 -1 2.89669142018544 2389 1881 4647 1737 2944 985 2413 3819 2103 3841 1714 2502 M13064 GO_PREPULSE_INHIBITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREPULSE_INHIBITION.html The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. 11/22 Gene Ontology BP GO:0060134 0.29162321609407 0.342657278910532 2390 2220.09090909091 2390 0.0308574415262566 142 2.2865842641141 1.93048454247567 1 3.62566778784678 2507 2388 1601 979 3291 2390 1664 4414 142 2473 2572 2503 M14963 GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. 19/24 Gene Ontology BP GO:1903672 0.0428736635583454 0.065816943760139 2135 2353.27272727273 2390 0.00397570163789107 1117 1.07928439975156 1.34327873953093 1 4.34969068962304 2132 1117 1964 1667 1398 2469 2425 3897 2390 3241 3186 2504 M13538 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. 35/47 Gene Ontology BP GO:0055025 0.177673025877938 0.21957837700134 3720 2229 2392 0.017626189256013 257 1.23773592462252 1.38869093724122 1 2.77556822998837 3717 257 1430 1159 3257 2392 2831 2669 1987 1917 2903 2505 M11365 GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 46/67 Gene Ontology BP GO:0032480 0.0193324368926586 0.0346242605317707 2245 2606.36363636364 2393 0.00177313090411796 1112 0.840289154030957 0.893936616537462 1 4.18555743548834 2245 3382 3751 3387 1112 1900 1391 2393 4024 3791 1294 2506 M12330 GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 54/78 Gene Ontology BP GO:0045661 0.0399180337660858 0.06211993682729 4135 2394.90909090909 2393 0.00369647992339211 816 1.22758059227041 -1.30474140155534 -1 5.0541871015517 4132 1554 1041 1084 2109 4032 3641 2439 2393 816 3103 2507 M13691 GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that modulates the frequency, rate or extent of regulated secretory pathway. 117/188 Gene Ontology BP GO:1903305 0.380799873525787 0.433536043923535 4185 2552.45454545455 2398 0.042639403178699 763 1.08964774170023 -1.14739377740201 -1 1.34158107408056 4181 763 1750 998 2398 4146 3179 3854 1430 1887 3491 2508 M12589 GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. 19/36 Gene Ontology BP GO:0042088 0.011133856067241 0.0224656688121735 1175 2328.81818181818 2399 0.00101732775089945 728 0.771190722043602 0.823089849124153 1 4.33582107158797 1172 3527 3051 3628 933 1665 728 1860 3427 3227 2399 2509 M15272 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. 39/52 Gene Ontology BP GO:0001937 0.0889828053925099 0.121525386994819 2875 2459.36363636364 2399 0.00843634962615636 904 1.28284232438576 -1.28271842625141 -1 4.00396065661731 2875 1613 1267 2399 2316 3401 3408 3181 1524 904 4165 2510 M11198 GO_HEXOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. 13/22 Gene Ontology BP GO:0035428 0.0132349576094678 0.0256272400153365 2405 2140.90909090909 2401 0.00121047770527132 287 1.87192214525727 1.47713763693931 1 10.1736507880184 2401 1829 832 2490 3202 3706 2078 2611 287 663 3451 2511 M10872 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME.html A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. 13/33 Gene Ontology BP GO:0001977 0.0442494112636183 0.0672695983754418 2145 2708.54545454545 2402 0.00410593753101194 1384 0.9375331763673 0.856884682142046 1 3.74661933913257 2141 4556 2834 3611 1414 2349 1384 2402 3451 3276 2376 2512 M13957 GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of glucose across a membrane. 13/22 Gene Ontology BP GO:1904659 0.0132349576094678 0.0256272400153365 2405 2142.45454545455 2402 0.00121047770527132 288 1.87192214525727 1.47713763693931 1 10.1736507880184 2402 1830 833 2491 3203 3707 2079 2617 288 665 3452 2513 M11556 GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. 10/20 Gene Ontology BP GO:2000846 0.0639124785168945 0.0916157617187647 3600 2505.81818181818 2403 0.00598621994122031 1079 1.71440423344257 -1.59302644232436 -1 6.07370521671874 3599 2403 1415 2585 1542 1990 3117 4341 1422 1079 4071 2514 M13534 GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. 10/22 Gene Ontology BP GO:0021514 0.163043183851879 0.203935466253439 2430 2518.72727272727 2403 0.0160500576876097 1281 1.23255171975323 1.19832572291265 1 2.89915512443822 2427 2391 1590 2403 4191 3004 1281 2262 3418 2319 2420 2515 M10718 GO_DENDRITIC_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_CHEMOTAXIS.html The movement of a dendritic cell in response to an external stimulus. 9/38 Gene Ontology BP GO:0002407 0.00203727453088449 0.00659209902100524 3135 2405.18181818182 2404 0.000203914466370049 245 1.39572739316875 1.64950004202579 1 10.3967783451564 3133 2404 4257 1285 539 3573 4415 814 245 2183 3609 2516 M16952 GO_POSITIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSSIFICATION.html Any process that activates or increases the frequency, rate or extent of bone formation. 96/117 Gene Ontology BP GO:0045778 2.47908341813611e-05 0.000264385761594786 2000 2017.90909090909 2404 2.25373759479957e-06 255 1.53773641958153 1.56852118395092 1 18.7992056423502 1996 2587 284 3283 3240 2518 2707 2404 1277 255 1646 2517 M16610 GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. 20/23 Gene Ontology BP GO:0006490 0.263847007914083 0.312944207959273 2395 2656.72727272727 2405 0.0274628739967368 1351 0.958400309560328 -0.920770544198014 -1 1.6425510193182 2393 3165 3613 2405 4142 2057 2034 2157 1351 3332 2575 2518 M11996 GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 108/157 Gene Ontology BP GO:0002224 0.291741962365299 0.342710262783574 2865 2442 2407 0.0308722116364667 777 1.1926736036417 1.1104072750165 1 1.88575954277541 2862 777 1594 1024 3842 3029 1998 3199 1553 2407 4577 2519 M12360 GO_ENAMEL_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENAMEL_MINERALIZATION.html The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. 10/13 Gene Ontology BP GO:0070166 0.438559266775205 0.488653320954269 2150 2463.27272727273 2408 0.0511240328439173 654 1.30100391435988 1.08728244200339 1 1.37268134286342 2147 2408 1840 2509 3454 2719 2003 3914 654 2316 3132 2520 M13578 GO_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_GENOME_REPLICATION.html Any process involved directly in viral genome replication, including viral nucleotide metabolism. 21/31 Gene Ontology BP GO:0019079 0.00151066999976001 0.00536166858038393 3005 2132.09090909091 2408 0.000137428029736362 11 0.917420855710972 0.944432230135333 1 7.11164594592637 3003 392 3443 586 463 3736 2408 4157 11 3379 1875 2521 M11541 GO_MAGNESIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSPORT.html The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/15 Gene Ontology BP GO:0015693 0.0628202144670151 0.0901579486126953 2815 2274.45454545455 2409 0.00588083448697052 751 0.792305641429874 -1.04177928718417 -1 2.82007597594075 2813 1171 2700 751 2160 2384 2842 1385 3616 2788 2409 2522 M11842 GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. 26/54 Gene Ontology BP GO:0021522 0.00208957918770083 0.00670538755887721 2580 2371.09090909091 2409 0.000190142411943218 523 1.29964028484791 -1.67816953150147 -1 9.64740917606659 2578 3121 2247 3238 523 2075 589 3841 2111 2409 3350 2523 M16073 GO_POSITIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 350/563 Gene Ontology BP GO:0051047 0.00109344604453305 0.00422319146674661 2030 2324.72727272727 2410 9.94536262329576e-05 512 1.22583541701632 1.30093072865563 1 9.94043537076873 2030 2950 512 3534 2717 2410 2287 1650 3387 605 3490 2524 M15781 GO_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 40/56 Gene Ontology BP GO:0046686 0.0993588726200403 0.133079111773474 3515 2778.18181818182 2411 0.00946838131569773 801 1.12280033047489 -1.18133289984554 -1 3.35170004315123 3511 2181 1869 801 1744 4205 4252 3522 2411 1927 4137 2525 M10299 GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION.html The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 11/22 Gene Ontology BP GO:0086069 0.309218037196039 0.361505408812354 3975 2413.81818181818 2413 0.0330708894746229 1091 1.33476479462956 -1.74211599016441 -1 2.00587622151514 3974 1224 2113 1091 2413 1551 2191 2615 4252 2466 2662 2526 M14794 GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. 38/54 Gene Ontology BP GO:0048169 0.0504091421006403 0.0751293203697243 1575 2647.27272727273 2413 0.00469114957381934 667 1.37140403899739 1.33231684436982 1 5.26039492902301 1573 4081 2155 3452 3586 2413 667 2407 3324 2150 3312 2527 M12182 GO_BIOTIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOTIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. 12/13 Gene Ontology BP GO:0006768 1.99596254736296e-05 0.000223788282719996 4075 2264 2414 1.81452786916092e-06 51 0.967538016346891 -1.05294228751346 -1 12.0639350446327 4074 508 2414 148 51 3385 4077 2286 1640 3193 3128 2528 M12935 GO_LEFT_RIGHT_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). 16/20 Gene Ontology BP GO:0070986 0.00408482777860641 0.0109592057706747 2415 2043.90909090909 2414 0.000372039274127909 630 0.967096278154088 1.11787993398994 1 6.47071224380406 2414 2824 2775 2193 672 2672 1695 1177 630 2995 2436 2529 M16057 GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT.html The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. 17/21 Gene Ontology BP GO:0060525 0.270956343324555 0.319746351886674 3400 2384.72727272727 2414 0.0283204812380721 676 1.22511580288069 1.02852823714718 1 2.06351173691613 3396 1761 1579 676 3575 2414 1966 2594 2546 1484 4241 2530 M16739 GO_METANEPHROS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_MORPHOGENESIS.html The process in which the anatomical structures of the metanephros are generated and organized. 21/38 Gene Ontology BP GO:0003338 0.0619037947641669 0.0892035791383303 2615 2139.63636363636 2414 0.00579250121647975 423 1.53010287568721 1.39324092950706 1 5.48024570688779 2612 1062 1141 423 4453 2763 2414 3611 455 1461 3141 2531 M14609 GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 26/29 Gene Ontology BP GO:0010888 0.0305266999113305 0.0498738534717067 2725 2173.27272727273 2415 0.00281442701320754 1069 1.36729413607338 1.38255927631513 1 6.07639943277993 2724 1677 1202 1069 1278 3714 2801 1722 2654 2415 2650 2532 M14646 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that stops, prevents, or reduces the rate of leukocyte degranulation. 7/18 Gene Ontology BP GO:0043301 0.0031281299510226 0.00903487812669655 2805 2125.36363636364 2415 0.000313254203317089 139 0.972370182388042 1.20037977426775 1 6.78483778695595 2805 546 4507 756 624 3913 2949 2415 139 1810 2915 2533 M16964 GO_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a higher concentration of a chemical. 42/52 Gene Ontology BP GO:0050918 0.014897961401635 0.0281560578398895 1835 2430.54545454545 2417 0.00136361948758611 599 1.67594547100085 1.93247891109781 1 8.87324309496265 1831 4404 1485 4546 3362 2580 2721 769 2022 2417 599 2534 M15083 GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 49/59 Gene Ontology BP GO:0051784 0.0543542628898378 0.0800856191343937 2420 2470 2418 0.00506777574314638 1318 0.863355987494122 -0.791437796727938 -1 3.22579065287424 2418 3367 3692 2673 1573 1906 2741 1318 1988 3643 1851 2535 M14187 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE.html The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. 14/15 Gene Ontology BP GO:1990126 0.0366640707050029 0.0581055589204287 1490 2385.81818181818 2419 0.00338997662646262 535 0.610509727500467 0.588280981326755 1 2.56878647711005 1489 2361 3733 3561 2860 849 535 2419 2933 4570 934 2536 M12815 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that stops or decreases the rate or extent of glial cell proliferation. 14/16 Gene Ontology BP GO:0060253 0.276578534482573 0.326050144653512 3730 2360.27272727273 2420 0.0290040931279788 271 1.6500204056131 1.6577398368214 1 2.73506202806004 3730 1800 2244 919 2420 3179 1628 3190 271 2790 3792 2537 M15280 GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. 1586/2144 Gene Ontology BP GO:0071822 0.0776862440590291 0.107934933892703 2420 2592.63636363636 2420 0.00805436973798183 774 1.03751339856696 -1.05675610822186 -1 3.41890850478487 2420 1876 4546 1720 2839 774 2423 4104 2169 3902 1746 2538 M16695 GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERAD pathway. 17/17 Gene Ontology BP GO:1904294 0.0215030330823943 0.0375524859243524 2810 2229.63636363636 2420 0.0019741934277053 441 0.763567383344431 -0.88459410056078 -1 3.710380798421 2809 441 3266 2420 3910 796 952 893 4262 3541 1236 2539 M16106 GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT.html The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. 13/18 Gene Ontology BP GO:0021891 0.00682300202909929 0.0152999655139272 3550 2332.72727272727 2422 0.00062220499833055 666 1.47968081059499 1.36355498497482 1 9.17289901273585 3548 1799 799 2422 809 3943 3115 3087 1127 666 4345 2540 M16454 GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 138/204 Gene Ontology BP GO:0032479 0.0677386515646678 0.0963582836228674 1275 2835.36363636364 2422 0.00635626627530708 1272 0.949331788574275 1.04740411172808 1 3.28734423688167 1272 4316 3845 4630 1561 2090 1374 2422 3856 3893 1930 2541 M11860 GO_PEPTIDYL_PROLINE_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_HYDROXYLATION.html The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. 11/13 Gene Ontology BP GO:0019511 0.00310372729635927 0.00897553953384691 2150 2421.27272727273 2423 0.000282555877873806 218 1.87455185078606 1.73401619414938 1 13.108160115051 2146 4577 2423 3938 3235 2876 3596 336 218 1801 1488 2542 M15016 GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 40/45 Gene Ontology BP GO:0002753 0.0110637617652296 0.0223533145868924 270 2090.54545454545 2423 0.0010108905585712 252 0.804805651323395 0.785217075373727 1 4.53126848765345 269 3402 3679 2884 2423 541 252 1172 3454 3575 1345 2543 M14059 GO_NEGATIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BINDING.html Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 174/229 Gene Ontology BP GO:0051100 0.0297440197933607 0.0489087881882097 1075 2437.27272727273 2424 0.00274126722631491 476 1.06172848810305 1.27252262162921 1 4.7468547261963 1071 3643 3011 4391 3909 1288 884 2136 2424 3577 476 2544 M15682 GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS.html The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. 139/167 Gene Ontology BP GO:0060560 0.00417444777458139 0.0110929214706609 2450 2275.81818181818 2424 0.000380217254170631 658 1.23427493742176 1.23767875849902 1 8.23908908848488 2449 2023 658 1638 2424 2187 2596 4531 2585 863 3080 2545 M16122 GO_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. 131/195 Gene Ontology BP GO:0055001 0.112837991117025 0.148315020527547 1740 2780.27272727273 2424 0.010825313173405 1294 1.10306517723576 1.11683555144952 1 3.11506482656356 1738 3656 1294 4165 3893 3769 2424 1771 3844 2228 1801 2546 M10887 GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. 202/261 Gene Ontology BP GO:0032104 0.22671447691503 0.272443817429142 4215 2856.54545454545 2425 0.0231023160444235 702 0.84385719563601 -0.770961392934674 -1 1.61862160636639 4212 702 4027 921 2139 2425 4601 4390 2055 4292 1658 2547 M15116 GO_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 92/111 Gene Ontology BP GO:0034332 0.10655561728572 0.141093707236896 1220 2358.63636363636 2425 0.0101905565210224 1220 1.25263511411113 1.15389855586586 1 3.63173538179769 1220 2586 1281 3202 3760 2178 1992 2889 2425 1694 2718 2548 M15797 GO_ADENOHYPOPHYSIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOHYPOPHYSIS_DEVELOPMENT.html The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. 6/17 Gene Ontology BP GO:0021984 0.0527072471561741 0.0779551242904254 3105 2672.90909090909 2425 0.00540007652883848 734 2.33835568259319 2.13454570096921 1 8.84872335735433 3105 2425 4573 1540 4563 2176 734 4454 1208 1576 3048 2549 M13209 GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that modulates the frequency, rate or extent of a response to nutrient levels. 202/261 Gene Ontology BP GO:0032107 0.22671447691503 0.272443817429142 4215 2855.09090909091 2426 0.0231023160444235 703 0.84385719563601 -0.770961392934674 -1 1.61862160636639 4213 703 4028 922 2140 2426 4602 4364 2056 4293 1659 2550 M13730 GO_ECTODERMAL_PLACODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_DEVELOPMENT.html The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0071696 0.0523253709712501 0.0775382009965691 1670 2440.72727272727 2426 0.00487390686876904 891 1.00966871961492 0.700099390308594 1 3.82273368781965 1666 3868 3044 2666 3389 1991 891 1304 1689 3914 2426 2551 M15395 GO_KETONE_BODY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BODY_METABOLIC_PROCESS.html The chemical reactions and pathways involving ketone body. 9/14 Gene Ontology BP GO:1902224 0.00402270165470566 0.0108508004633887 2555 2413.72727272727 2426 0.000403000221917885 406 1.3446652552086 -1.55995224818315 -1 9.02098693087131 2552 4586 4551 3035 2426 1840 1540 406 1091 2886 1638 2552 M10940 GO_CELLULAR_RESPONSE_TO_SUPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_SUPEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. 14/21 Gene Ontology BP GO:0071451 3.04031344856198e-07 6.20463968252582e-06 3750 2293.45454545455 2427 2.76392169883764e-08 2 1.23125029179765 -1.03734536677862 -1 21.9098132567108 3748 1191 1818 1334 2 2427 2715 1933 4003 2785 3272 2553 M15688 GO_ECTODERMAL_PLACODE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_MORPHOGENESIS.html The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0071697 0.0520215321808904 0.0771616797059876 1670 2441.81818181818 2427 0.00484490632707444 892 1.00966871961492 0.700099390308594 1 3.83003138843919 1667 3869 3045 2667 3390 1992 892 1301 1690 3920 2427 2554 M15152 GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 14/21 Gene Ontology BP GO:0071450 3.04031344856198e-07 6.20463968252582e-06 3750 2281.54545454545 2428 2.76392169883764e-08 3 1.23125029179765 -1.03734536677862 -1 21.9098132567108 3749 1192 1819 1335 3 2428 2716 1781 4004 2797 3273 2555 M15428 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter. 19/20 Gene Ontology BP GO:0045943 0.0617235065753412 0.0890264959997095 2430 2301.63636363636 2428 0.00577513255661522 443 0.771553661944374 0.893155786780034 1 2.76040179515423 2428 443 3439 2436 1529 2338 3015 2101 465 3650 3474 2556 M15785 GO_ECTODERMAL_PLACODE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_FORMATION.html The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0060788 0.0447995990454737 0.067944111590153 1670 2435.45454545455 2428 0.00415806906343618 893 1.00966871961492 0.700099390308594 1 4.02075409966538 1668 3870 3046 2668 3391 1993 893 1221 1691 3921 2428 2557 M10124 GO_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ACTIVATION.html A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. 409/670 Gene Ontology BP GO:0045321 0.00129290023105727 0.00480116901445288 2295 2452.54545454545 2429 0.000117605515534599 527 1.14107363489268 1.09883399625647 1 9.03503033339845 2291 1925 527 2492 3965 2429 2136 3217 2621 1000 4375 2558 M10435 GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 24/25 Gene Ontology BP GO:0043555 0.0697814311179274 0.0989013094705197 2910 2797.36363636364 2430 0.00655439834844076 1108 0.77356654060639 -0.829054736926317 -1 2.64681012138235 2906 2273 3799 2430 1574 2353 1795 4075 1108 4125 4333 2559 M10630 GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. 20/23 Gene Ontology BP GO:0045618 0.00238315336160764 0.00734568264334653 2680 1985.90909090909 2430 0.000216885348908033 487 1.23147642737767 1.13126173880443 1 8.97409538109295 2679 1071 2669 855 552 2430 2479 3465 487 2348 2810 2560 M12966 GO_PHOTORECEPTOR_CELL_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_MAINTENANCE.html Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. 37/52 Gene Ontology BP GO:0045494 0.342963691483537 0.395296025878846 3475 2784.18181818182 2430 0.0374634817858369 1525 1.50687054889446 -1.29530269245551 -1 2.06595698365508 3475 2196 1640 1525 3042 2388 4395 4458 2268 2809 2430 2561 M11164 GO_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 28/34 Gene Ontology BP GO:0010874 0.00339779318107633 0.00960506176886281 2435 2348.90909090909 2431 0.000309368389325853 619 1.26388026403945 -1.22918331846908 -1 8.70723675283709 2431 1664 2138 2672 619 1371 3438 2509 3893 2976 2127 2562 M14711 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization. 21/22 Gene Ontology BP GO:0031116 0.000371047596953875 0.00197087268108035 3900 2258.27272727273 2431 3.37372901708596e-05 258 1.18364769536697 -1.22005616974696 -1 10.9373919282222 3896 3825 3304 1431 258 3795 3251 1332 452 2431 866 2563 M15546 GO_ACTIN_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 193/243 Gene Ontology BP GO:0007015 0.00577426225782821 0.0134540021460564 3785 2333.90909090909 2431 0.000526315789473684 182 1.10866360013875 -1.12169071339429 -1 7.08185553562869 3782 710 2431 182 850 4483 3621 4355 1134 757 3368 2564 M16216 GO_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_MIGRATION.html The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. 21/26 Gene Ontology BP GO:0014812 0.00732549634112144 0.0162021781295408 2195 2388.90909090909 2432 0.000668182080445095 551 1.58818692756267 2.17425942147199 1 9.71122394750855 2191 2798 1692 3089 4281 2065 1192 551 3056 2931 2432 2565 M13979 GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 173/208 Gene Ontology BP GO:0090090 0.448293696940057 0.497711899752347 4420 2674.72727272727 2433 0.0526315789473684 404 1.03073224689736 -0.940750986868507 -1 1.0571925587304 4419 714 2132 404 3950 2433 3743 3976 1356 2147 4148 2566 M12087 GO_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION.html The attachment of one cell to another cell via adhesion molecules. 571/888 Gene Ontology BP GO:0098609 1.45188510971504e-07 3.23235474426032e-06 2350 2694.72727272727 2434 1.45188520457371e-08 81 1.32007879579875 1.25538945992519 1 24.7694149523987 2349 1906 4343 1955 3326 1975 2434 3784 2991 81 4498 2567 M14216 GO_DETECTION_OF_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_VISIBLE_LIGHT.html The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 39/83 Gene Ontology BP GO:0009584 0.0623799109864079 0.0897229446119802 2425 2432.09090909091 2434 0.00583838404265406 1498 1.15168939432588 1.33415310729667 1 4.11234818099358 2422 2180 1648 1498 1534 2438 3055 2434 3713 2945 2886 2568 M11041 GO_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane. 134/181 Gene Ontology BP GO:0061025 0.00533527139503151 0.0131997604849371 2565 1944.63636363636 2435 0.000486204926053646 1 1.05140860752586 -1.0943629160436 -1 6.74535860036062 2564 1 3414 558 2435 1493 3745 2555 782 3709 135 2569 M14008 GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. 107/154 Gene Ontology BP GO:2000117 0.0181907085652951 0.0329728737648298 4070 2510.81818181818 2435 0.00166753481892841 624 1.06828310394349 -0.956811754023485 -1 5.40162688076447 4067 782 2435 624 1091 3807 3611 3474 1716 2388 3624 2570 M14745 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 10/16 Gene Ontology BP GO:0034375 0.229406117588577 0.275536051920405 3595 2483.27272727273 2437 0.0234119308411678 213 1.5598543787384 -2.02727110382949 -1 2.97489930314993 3890 3592 1861 2069 2144 2479 3593 3388 213 1650 2437 2571 M15500 GO_POSITIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 995/1446 Gene Ontology BP GO:0051050 0.000988640972185604 0.0039418564212336 1775 2443.09090909091 2437 9.89081082718431e-05 348 1.1583719275171 1.20114579296913 1 9.51135426722099 1774 2437 4559 2985 2835 2280 2254 1577 3068 348 2757 2572 M10119 GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that stops or reduces the activity of a phosphoprotein phosphatase. 17/18 Gene Ontology BP GO:0032515 0.00577426225782821 0.0134540021460564 2715 2069.81818181818 2438 0.000526315789473684 30 1.11710031923829 -1.09859050343214 -1 7.13582825049348 3507 422 2715 157 1396 2955 2438 2713 30 2032 4403 2573 M15889 GO_SKIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_DEVELOPMENT.html The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. 246/353 Gene Ontology BP GO:0043588 1.13310163767698e-12 1.12177062130021e-10 2485 2122.18181818182 2438 1.03009239788869e-13 31 1.47046825809168 1.23955134903109 1 50.0129829096481 2485 2498 31 1751 3455 2337 2286 3001 2889 173 2438 2574 M16264 GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that activates or increases the frequency, rate or extent of receptor recycling. 16/17 Gene Ontology BP GO:0001921 0.000728272952776649 0.00317884995241065 2440 2521.90909090909 2438 6.62285588238036e-05 22 0.804943372027206 -0.918039167926653 -1 6.86323759439847 2438 3202 3178 2159 1705 2261 4323 575 4370 3508 22 2575 M10099 GO_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMORY.html The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). 103/156 Gene Ontology BP GO:0007613 0.0757822743104618 0.105699916776552 3755 2756.45454545455 2439 0.00713872476985026 1197 1.25567795118468 1.27436749382262 1 4.17907932223671 2296 3322 1197 3726 3755 1532 2439 3610 3751 2425 2268 2576 M16285 GO_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. 91/129 Gene Ontology BP GO:0001823 1.87293199379114e-05 0.000211523120560926 1880 2384.36363636364 2439 1.70267994442196e-06 275 1.3107376822833 1.29950028024462 1 16.4566697736602 1880 2584 275 2302 3982 2512 2393 4606 2755 500 2439 2577 M16903 GO_PIGMENT_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_METABOLIC_PROCESS.html The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. 52/73 Gene Ontology BP GO:0042440 0.0152244185489479 0.0286334759532153 2440 2320.36363636364 2439 0.00139370968867235 1029 0.931637477555787 -0.892016859339544 -1 4.90453208110426 2439 1564 3409 1089 1029 1802 2983 3462 1137 3730 2880 2578 M10587 GO_PROSTATE_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a prostate gland are generated and organized. 31/37 Gene Ontology BP GO:0060512 0.049826464713562 0.074403896120733 4585 2572.63636363636 2440 0.00463564411206968 1093 1.28689112035941 1.16823921528378 1 4.95410529889253 4581 2706 1093 2440 2138 4151 3236 1679 3708 1242 1325 2579 M12670 GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 133/262 Gene Ontology BP GO:0038095 0.00695788594386854 0.0155350495666124 3105 2357.90909090909 2440 0.000634544491767005 749 0.79387437091341 -0.712737248085002 -1 4.89850307735453 3102 749 3804 890 814 1691 3268 3314 1763 4102 2440 2580 M13289 GO_PROTEIN_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MANNOSYLATION.html The addition of a mannose residue to a protein acceptor molecule. 20/21 Gene Ontology BP GO:0035268 0.0544855788800562 0.080228290673703 1375 2524.09090909091 2441 0.00508033654515422 1111 0.712313485149829 -0.618586585045162 -1 2.65769669429567 1374 4168 3721 3967 3197 1111 1387 1320 2441 3695 1384 2581 M13386 GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 125/164 Gene Ontology BP GO:0016051 0.00413292598058746 0.0110329917313101 4415 2508.36363636364 2441 0.000376428235285261 490 1.12991468388938 -1.06816804408187 -1 7.55064569858241 4412 756 2441 490 677 3119 4474 4201 874 2205 3943 2582 M15725 GO_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_NUCLEATION.html The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. 22/25 Gene Ontology BP GO:0045010 0.0138608513949952 0.0265737707214309 2735 2274.45454545455 2441 0.00126808711451591 1007 0.818212919538619 -0.985233102924559 -1 4.39681433901858 2732 3491 3371 2834 1007 1854 1249 2441 1464 2988 1588 2583 M15302 GO_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. 21/24 Gene Ontology BP GO:0055070 0.000782083063946907 0.00334162763686406 2445 2224.18181818182 2443 7.11237479003687e-05 360 1.1204202544794 -1.3690285293747 -1 9.4742068915951 2443 2794 2714 2119 360 3872 4434 871 784 2929 1146 2584 M16950 GO_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MITOCHONDRION.html The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. 60/69 Gene Ontology BP GO:0006626 0.0520132051315112 0.0771616797059876 555 2620.09090909091 2443 0.00484411165304871 554 0.613154318579526 -0.599424823048327 -1 2.32172425663557 554 3722 4144 3870 2443 1015 1003 1300 4209 4653 1908 2585 M16939 GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of cell proliferation. 749/1017 Gene Ontology BP GO:0008285 2.15544387709002e-06 3.38827039192563e-05 2080 2394.36363636364 2444 2.15544596776512e-07 122 1.20943354331491 1.2442686816414 1 18.47283169805 2078 2444 4653 2751 3361 1825 1814 1897 2578 122 2815 2586 M10589 GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 96/133 Gene Ontology BP GO:0032481 0.123863346595688 0.160729161427987 1175 2820.72727272727 2447 0.0119492343215435 1149 0.987070783757497 1.07236407611364 1 2.6685637450659 1175 4347 3676 4631 1981 2447 1149 1740 3780 3897 2205 2587 M14101 GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 16/18 Gene Ontology BP GO:0046475 0.0182733082288626 0.0330461111727634 3665 2694.27272727273 2447 0.00167517054356469 1015 1.22424519279652 -1.09170893529117 -1 6.18775135857149 3661 2328 1744 2282 1094 4311 3616 1015 2650 2447 4489 2588 M14563 GO_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. 653/787 Gene Ontology BP GO:0007005 0.0428571781577945 0.0658133498244943 405 2445.09090909091 2447 0.00437068658089129 404 0.842973283360949 -0.790519605893011 -1 3.39505239617573 404 2447 4501 3034 3451 550 1040 1922 3246 4428 1873 2589 M13272 GO_PROTEIN_AUTOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOUBIQUITINATION.html The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. 47/55 Gene Ontology BP GO:0051865 0.0895074505218032 0.122134359905557 2880 2477.81818181818 2448 0.00848827512709445 821 0.771965759146456 0.656012514072717 1 2.39945551303345 2426 2162 4096 2448 2880 1419 931 2955 821 4240 2878 2590 M11112 GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE.html A process that modulates the size of a cellular component. 383/480 Gene Ontology BP GO:0032535 0.000293269627393296 0.00168884105972897 3070 2440.36363636364 2449 2.66644298923221e-05 271 1.14302650106006 1.16618585895195 1 10.8237746587694 3067 1351 762 727 2449 4200 3567 4181 1647 271 4622 2591 M13727 GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 86/103 Gene Ontology BP GO:0042451 0.122081234017868 0.158804579783377 925 2476.72727272727 2450 0.0117666982678838 925 0.674161225403046 -0.628888853577448 -1 1.83128546792502 925 2089 4092 3120 2710 962 1609 2271 2741 4275 2450 2592 M12838 GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 142/173 Gene Ontology BP GO:0010594 0.00190672178133332 0.00632808591194289 2135 2305.81818181818 2451 0.000173488757203248 525 1.20980967867472 1.31028832672488 1 9.08388079614177 2133 2541 563 2451 2902 4265 3299 2269 1846 525 2570 2593 M13918 GO_RETINOIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. 16/33 Gene Ontology BP GO:0042573 0.0207549405489038 0.0365667316827147 3645 2370.18181818182 2451 0.00190485179776177 913 1.51271892326108 -1.42007411292674 -1 7.42092122784148 3643 3190 913 1963 1664 2840 3869 1514 2451 959 3066 2594 M16242 GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 86/103 Gene Ontology BP GO:0046129 0.122081234017868 0.158804579783377 930 2468.36363636364 2451 0.0117666982678838 926 0.674161225403046 -0.628888853577448 -1 1.83128546792502 926 2090 4093 3121 2711 963 1610 2169 2742 4276 2451 2595 M12191 GO_DNA_CONFORMATION_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CONFORMATION_CHANGE.html A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. 234/419 Gene Ontology BP GO:0071103 0.138490733650613 0.176935031212604 985 2705.36363636364 2453 0.0134603578932118 984 1.00003232182827 -1.18258660517573 -1 2.56110533128087 984 3635 3941 3418 4335 1032 2197 2453 2005 4135 1624 2596 M15219 GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. 16/22 Gene Ontology BP GO:0010310 0.0010430303729034 0.00409915298283829 2455 2695.90909090909 2453 9.4865927908786e-05 404 1.09084730942292 -0.784325277151429 -1 8.89291281311301 4263 1768 2412 2633 404 3937 4451 483 2453 2453 4398 2597 M14847 GO_DETERMINATION_OF_ADULT_LIFESPAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETERMINATION_OF_ADULT_LIFESPAN.html The control of viability and duration in the adult phase of the life-cycle. 16/19 Gene Ontology BP GO:0008340 0.0834209866754062 0.114907593546674 2065 2728.36363636364 2454 0.00788754724502029 1457 0.89157370526118 -0.89157370526118 -1 2.85362322051874 2062 3890 3153 2454 2212 2234 2555 1513 4565 3917 1457 2598 M11532 GO_REGULATION_OF_WATER_LOSS_VIA_SKIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WATER_LOSS_VIA_SKIN.html A process that modulates the rate or extent of water loss from an organism via the skin. 28/34 Gene Ontology BP GO:0033561 0.0115190131163779 0.0230628089632126 1525 2608.36363636364 2456 0.00105270650328062 808 2.5947711774946 -2.81811006795108 -1 14.5125752387402 1522 4463 808 3732 4092 1360 2675 2456 3877 1712 1995 2599 M14710 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 1135/1522 Gene Ontology BP GO:0031401 0.000717821633794115 0.0031475773195708 2315 2306.45454545455 2456 7.18053609816156e-05 290 1.16481136447066 1.22681068410392 1 9.95346798772054 2312 574 4514 290 3599 2954 2456 2914 2115 328 3315 2600 M11149 GO_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that modulates the frequency or rate of macrophage activation. 20/34 Gene Ontology BP GO:0043030 0.0170582061538246 0.0313227439754325 2035 2240.81818181818 2457 0.001562902245067 691 1.62148910400173 1.46418233068702 1 8.32796853080715 2035 3161 887 2801 2072 2684 2588 3400 1873 691 2457 2601 M12850 GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. 18/18 Gene Ontology BP GO:0035024 0.00241600181291108 0.00741120104158225 3980 2455.18181818182 2457 0.000219878100958315 556 1.67585996554733 -1.76604038976836 -1 12.194187677667 3978 2814 2037 1271 556 3229 3321 2457 1170 2132 4042 2602 M16501 GO_RESPONSE_TO_UV_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_B.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. 16/19 Gene Ontology BP GO:0010224 0.00151480649379931 0.00537225199363428 3200 2641 2457 0.000137804592540068 464 1.4305854095204 1.12975779674664 1 11.0913608783316 3199 2333 1985 3264 464 4410 2354 1458 4383 2457 2744 2603 M10751 GO_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. 506/646 Gene Ontology BP GO:0030029 0.00336998019547268 0.0095671249844627 2020 2336.63636363636 2458 0.000337510167466796 75 1.09004431260127 1.04025452163377 1 7.51456934013138 2017 1329 4259 75 2458 3446 2818 2663 2132 448 4058 2604 M13525 GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. 20/23 Gene Ontology BP GO:0006488 0.413594137301428 0.465180933252005 2395 2682.81818181818 2458 0.0473637168456266 1350 0.958400309560328 -0.920770544198014 -1 1.07844728869332 2392 3164 3612 2404 4141 2056 2033 2458 1350 3327 2574 2605 M15312 GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 30/34 Gene Ontology BP GO:0090181 0.0195278403423479 0.0348802461086161 4605 2359.18181818182 2458 0.00179121456373368 63 1.14948702034691 -1.33680817481906 -1 5.71705160841687 4601 988 2462 836 3864 3369 4150 856 63 2304 2458 2606 M10392 GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 15/18 Gene Ontology BP GO:0009151 0.0197301262312365 0.0351375514749004 2440 2605.54545454545 2459 0.00180993861216406 1124 1.00544558242494 -1.13518647878362 -1 4.98834306145189 2440 3877 3191 3491 1124 1968 2459 2364 1187 3431 3129 2607 M11454 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 93/113 Gene Ontology BP GO:0008630 0.328402279004399 0.381156349266018 3370 2501.09090909091 2459 0.0355434746625916 59 0.957061943271055 1.12067166548711 1 1.36002822745364 3368 59 2888 425 2319 2459 1929 4347 2186 3171 4361 2608 M11941 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. 498/657 Gene Ontology BP GO:1902532 0.107613420868406 0.142372831191553 1915 2293.45454545455 2459 0.010297149905977 964 1.0592485560333 1.11030497954911 1 3.05521370677377 1911 2459 2621 2839 2606 2154 2297 2646 2807 964 1924 2609 M14026 GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT.html The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. 1226/1793 Gene Ontology BP GO:0006928 1.1853689536842e-12 1.14906702947762e-10 1600 2210.18181818182 2461 1.18536895368483e-13 18 1.2526440014315 1.26130979500951 1 42.5581340140795 1596 1274 4467 1703 2663 2689 2461 1916 2589 18 2936 2610 M12246 GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an external stimulus. 941/1381 Gene Ontology BP GO:0032101 3.50626852272213e-05 0.000339888904921377 2010 2366.09090909091 2463 3.50632384658597e-06 186 1.23871505342353 1.309396406242 1 14.6794774935146 2008 1291 4357 1181 3596 3022 2719 2327 2463 186 2877 2611 M15808 GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. 17/49 Gene Ontology BP GO:0045721 0.000481725763254817 0.00236863601522557 820 2058.63636363636 2463 4.38028433898785e-05 105 1.0031617218377 1.12389295119509 1 8.99417037217717 816 2819 2463 3478 3123 2386 516 105 3120 3540 279 2612 M15937 GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. 21/21 Gene Ontology BP GO:0043162 0.0309070551251365 0.0503597456449636 3850 2658.54545454545 2463 0.00284999950466643 1181 0.619745912911742 -0.54288917146122 -1 2.73946478627857 3848 1715 3856 1928 1282 2463 4420 1431 1181 4623 2497 2613 M10719 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. 11/15 Gene Ontology BP GO:0002583 0.0425804894402179 0.065474890074466 2890 2189.90909090909 2467 0.00394797015139649 1191 1.64561559989144 -1.66783916496514 -1 6.65042394669212 2890 2893 1407 2976 1460 1732 2578 1191 3182 2467 1313 2614 M11161 GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL.html Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 13/21 Gene Ontology BP GO:0045760 0.0226245538095758 0.0392074669929073 2775 2436.09090909091 2467 0.00207823892101508 1167 1.42961560890055 -1.38895016835075 -1 6.86464194358615 4335 1196 1182 2773 1167 2467 3526 2774 2004 1497 3876 2615 M14657 GO_CELLULAR_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 158/213 Gene Ontology BP GO:0071478 0.0165934180280441 0.0306628967770013 2470 2378.81818181818 2467 0.00151999190853003 1060 1.04794279250781 1.14129122406135 1 5.41159227778643 2467 1419 2761 2109 1060 1583 1064 4226 3097 2938 3443 2616 M10789 GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 11/25 Gene Ontology BP GO:0002281 0.06076918427873 0.0879225791196924 2150 2432.54545454545 2468 0.00568324526054574 1328 1.21886595541795 1.19376148686259 1 4.38952271870539 2148 2895 2142 2901 1523 2620 1328 2432 2987 2468 3314 2617 M14274 GO_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_SECRETION.html The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 40/87 Gene Ontology BP GO:0050663 0.0204103935213206 0.0360963744031565 1945 2694.81818181818 2468 0.00187293150026144 875 1.20245620190767 1.4627553007136 1 5.91979847114298 1943 3745 1471 3618 3704 2372 2431 875 4045 2971 2468 2618 M16394 GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. 15/24 Gene Ontology BP GO:0030826 0.0029996250503884 0.00876712020066408 3220 2218.45454545455 2469 0.000273065705546736 481 1.26530522255234 1.17184351948421 1 8.88856268891499 3218 481 1010 551 587 4081 2611 2469 3140 1769 4486 2619 M16776 GO_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ASSEMBLY.html Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 37/40 Gene Ontology BP GO:0030032 0.420933971158197 0.472294614853892 4215 2731.54545454545 2472 0.0484539163339052 250 1.1318465830993 -1.04302361889332 -1 1.25004303147995 4215 250 2227 754 4254 3515 4387 2472 2270 2437 3266 2620 M15906 GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 30/38 Gene Ontology BP GO:0046473 0.172560424376444 0.21382787073864 3015 2650.27272727273 2473 0.0170725112343313 743 1.11196228764204 0.819284901827613 1 2.53625893773666 3014 996 2473 743 4127 4361 4562 1918 833 2306 3820 2621 M11408 GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. 14/19 Gene Ontology BP GO:0035886 0.00813652173831518 0.0175599423229965 1905 2625.72727272727 2474 0.000742433703993064 855 1.25887487764466 1.25887487764466 1 7.54495724366329 1902 4573 2474 4287 855 1453 987 2625 4534 3357 1836 2622 M13698 GO_AMINO_SUGAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 11/17 Gene Ontology BP GO:0046348 7.76332683541282e-06 0.000103503609642338 3430 2258.27272727273 2476 7.05759475514442e-07 24 1.5448856086733 -0.951239896163608 -1 21.037874514 3426 3248 2130 2527 24 1460 2121 3184 1124 2476 3121 2623 M15977 GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. 117/146 Gene Ontology BP GO:0031098 0.0577240671289776 0.0841447632678987 3955 2498.90909090909 2476 0.00539061140315367 772 1.06253689993883 -1.09898614245181 -1 3.89445342420595 2712 772 2915 1593 3951 2313 2476 1349 2321 3131 3955 2624 M11223 GO_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTATIC_PROCESS.html Any biological process involved in the maintenance of an internal steady state. 1241/1868 Gene Ontology BP GO:0042592 7.87857509330059e-11 4.6403810011554e-09 2355 2252.09090909091 2477 7.87857509357991e-12 28 1.22042191972913 1.26084865234947 1 34.7611282606089 2352 1272 4287 1169 2477 2692 2603 2050 2520 28 3323 2625 M14640 GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosyl compound. 348/462 Gene Ontology BP GO:1901657 0.0377678373839476 0.0594594909641031 4365 2383.54545454545 2477 0.00349383903180779 142 0.824882530480265 -0.750812126128088 -1 3.44631540558458 142 2477 4091 2981 4361 485 856 1868 2897 4361 1700 2626 M13009 GO_TERPENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERPENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. 87/174 Gene Ontology BP GO:0006721 3.18089026202807e-06 4.75906186148445e-05 4065 2219.63636363636 2478 2.89172260105169e-07 232 1.47420929922667 -1.45005245329089 -1 21.7756844429416 4061 2083 232 2478 620 1567 3791 3571 2760 507 2746 2627 M11200 GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. 21/26 Gene Ontology BP GO:2000251 0.0944715254128241 0.127450277687988 940 2675.54545454545 2479 0.00898093340188854 937 1.01279101309753 1.01279101309753 1 3.08725509848754 937 3847 3083 4260 2479 2049 1323 1576 4380 3738 1759 2628 M11348 GO_RIBOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_ASSEMBLY.html The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. 57/75 Gene Ontology BP GO:0042255 0.0342971882778337 0.0548213043822605 4380 2726.81818181818 2480 0.00316762159645955 518 0.660218891356766 0.588369458956118 1 2.83584841241365 581 4376 4125 4620 1362 1181 518 2023 4377 4352 2480 2629 M14715 GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. 11/44 Gene Ontology BP GO:0002710 0.055874826717375 0.0820143749892573 2595 2864.18181818182 2481 0.00521331985135261 1496 1.07398038862921 1.08858064576343 1 3.97740557215511 2592 3918 2379 3718 1496 4540 1867 2009 4629 2481 1877 2630 M11647 GO_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CONTRACTION.html A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. 30/55 Gene Ontology BP GO:0003009 0.269117612270969 0.318141323652647 1660 2226.18181818182 2482 0.0280979465742811 978 0.874374111923721 0.767144880020036 1 1.47622422298829 1657 978 2978 996 2664 2482 1608 2838 1744 3470 3073 2631 M12658 GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 33/48 Gene Ontology BP GO:0097237 0.0283029679146816 0.0471851342554689 1020 2331 2482 0.00260670739479328 837 0.95308877856118 1.02805002049782 1 4.3108231155354 1017 3431 2482 3797 1239 1399 837 3115 4185 3296 843 2632 M14785 GO_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-8 secretion. 11/21 Gene Ontology BP GO:2000482 0.33289935857605 0.385222759376862 4560 2527.09090909091 2482 0.0361323682386586 89 1.57103361521277 -1.24282775439821 -1 2.21459497001422 4560 516 1628 604 2442 4058 3640 3401 89 2482 4378 2633 M12749 GO_POSITIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 257/394 Gene Ontology BP GO:0043270 8.29508209199076e-10 3.54101073156266e-08 2340 2299.36363636364 2483 7.54098372283493e-11 79 1.22520362137715 -1.22320170219544 -1 31.2003481712921 2340 1954 79 2483 1927 3392 2884 3987 3398 295 2554 2634 M16292 GO_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 308/463 Gene Ontology BP GO:0009416 0.08743841526257 0.119644007120102 2635 2546.45454545455 2484 0.00828365493537496 1680 1.10839405414841 -1.09727537062023 -1 3.48370726758958 2635 2484 2680 2147 1680 2018 2060 4078 2070 2813 3346 2635 M10808 GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. 120/184 Gene Ontology BP GO:0048706 0.00018870355061778 0.00120114585639471 1030 2109 2485 1.7156339862223e-05 388 1.26752869244169 1.31345231716258 1 12.6452417365302 1026 2560 388 2684 2046 2485 1954 2854 3397 1030 2775 2636 M13315 GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. 16/20 Gene Ontology BP GO:0035358 0.0487486465223959 0.0729583313826659 3130 2437.54545454545 2485 0.0045330533734564 654 1.58133903258614 -1.81048780121209 -1 6.13613984619621 3128 3199 1796 3223 3436 2570 654 1696 2485 2446 2180 2637 M15424 GO_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 246/358 Gene Ontology BP GO:0009636 0.012108201878801 0.0239030391777942 2085 2321.09090909091 2485 0.00110685092479092 963 1.10515387369001 1.16883974031063 1 6.11629204618152 2084 2502 1473 1836 963 2986 2485 3132 2703 2294 3074 2638 M13902 GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of erythrocyte differentiation. 39/48 Gene Ontology BP GO:0045646 0.0403050523207553 0.0625594398948783 4325 2644.45454545455 2486 0.0037329975079706 239 0.939537527530845 1.05308965033932 1 3.85592071701121 4325 239 2444 1822 2448 4051 2486 1165 3422 2570 4117 2639 M15548 GO_CELL_VOLUME_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_VOLUME_HOMEOSTASIS.html Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. 33/45 Gene Ontology BP GO:0006884 0.167807640847305 0.209051928477245 4655 2817.09090909091 2487 0.0165605827439485 271 0.965250312141611 -0.785544069653618 -1 2.23259365798491 4651 271 2487 1483 1989 4362 3442 2408 3788 2165 3942 2640 M15474 GO_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of DNA replication. 174/211 Gene Ontology BP GO:0006275 0.172275297978318 0.213531422880424 3980 3013.72727272727 2488 0.0170417246207922 1742 0.963119056901028 0.953361171987539 1 2.19732125962243 2280 3977 3979 4285 2469 2488 1742 1914 1995 4082 3940 2641 M13506 GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. 23/28 Gene Ontology BP GO:0051570 0.0123917617574634 0.024369766465544 1105 2153.54545454545 2489 0.00113291956756061 267 1.21181472917399 -1.36630013144256 -1 6.67282303983067 1103 3494 3040 3167 1344 1285 2489 712 3307 3481 267 2642 M14198 GO_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MIGRATION.html The movement of a T cell within or between different tissues and organs of the body. 16/27 Gene Ontology BP GO:0072678 0.0603133573731933 0.0873989572897753 2890 2486.81818181818 2489 0.00563938573703357 1518 1.28917492283766 1.09120366830083 1 4.65477677799688 2886 2829 1672 1587 1518 2489 3282 2026 3559 1897 3610 2643 M16270 GO_DEFENSE_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_FUNGUS.html Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. 20/101 Gene Ontology BP GO:0050832 0.000105739408371929 0.000780961058975534 2540 2425.63636363636 2489 9.61313553690611e-06 355 2.17253283999652 2.19950812429495 1 23.0701885177348 2538 2297 355 3209 1528 4013 4518 4228 1150 357 2489 2644 M13417 GO_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. 32/65 Gene Ontology BP GO:0042461 0.128024977012552 0.165059633704463 2170 2381 2490 0.0123768146708122 1109 1.20613119937116 -1.01506270834134 -1 3.21555087907245 2169 3427 1924 2507 3146 1336 1109 2020 3282 2490 2781 2645 M14917 GO_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEATH.html Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 1539/2183 Gene Ontology BP GO:0010941 0.000171835610602689 0.00111981946237298 2410 2353.36363636364 2491 1.71848899413604e-05 253 1.12199162358263 1.1714669545486 1 11.3088949715642 2408 1261 4525 710 3190 2491 2684 3036 1949 253 3380 2646 M10476 GO_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of a cytokine. 547/853 Gene Ontology BP GO:0001817 0.00143520182939367 0.00515492627483987 1145 2429.18181818182 2492 0.000143612958472925 368 1.20150148262879 1.28270875696715 1 9.38723078819212 1145 3276 4243 2767 4432 2110 2009 1274 2605 368 2492 2647 M12736 GO_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION.html The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 121/184 Gene Ontology BP GO:0042113 0.43119990772354 0.48137552078638 1570 2366.81818181818 2493 0.05 14 1.06232065848752 1.07425039153036 1 1.1425612228892 1568 14 2049 1615 3801 2662 2132 3436 2780 2493 3485 2648 M13375 GO_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that modulates the frequency, rate, or extent of cellular extravasation. 21/37 Gene Ontology BP GO:0002691 0.0414946242885774 0.064123044441963 1390 2570.45454545455 2493 0.00384532482608035 1386 1.25020887452909 -0.979055735707971 -1 5.08863409104287 3092 2284 1387 2493 1386 1927 3151 3154 4330 2925 2146 2649 M11851 GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). 94/127 Gene Ontology BP GO:0043648 0.339059661354463 0.391183884027353 2495 2199.36363636364 2494 0.0369449466417409 851 1.32073114365182 -1.06370115702658 -1 1.82994525591102 2494 1475 1858 946 2780 1618 2503 3407 851 2757 3504 2650 M14871 GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. 39/42 Gene Ontology BP GO:0045839 0.0580690759291244 0.0845682035362178 2495 2645.36363636364 2494 0.00542372331318756 1355 0.815070860210547 -0.792558082254183 -1 2.97887246991365 2492 3398 3719 3119 2111 2494 2825 1355 2323 3817 1446 2651 M11727 GO_SPECIFICATION_OF_ORGAN_IDENTITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_ORGAN_IDENTITY.html The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. 13/21 Gene Ontology BP GO:0010092 0.000137060460708206 0.000959011013045539 2300 2408.18181818182 2495 1.24608182134954e-05 44 1.23161328239554 -1.1501413941993 -1 12.6983378729036 2300 4212 2495 4057 2702 1603 2453 44 2726 2695 1203 2652 M12321 GO_REGULATION_OF_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. 18/20 Gene Ontology BP GO:0090231 0.0989901482397122 0.132738086385989 2500 2346.27272727273 2496 0.00943152219824396 848 0.787201137328537 0.773233574270506 1 2.34970639088608 2496 2817 3416 3913 1797 848 1705 1829 2632 3143 1213 2653 M10225 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. 27/34 Gene Ontology BP GO:2000678 0.138838004392264 0.177281348638091 2820 2190.81818181818 2498 0.0134965163331424 247 1.90032654478673 2.16396690573941 1 4.87086095130576 2817 1014 1486 2525 3823 3091 2498 1801 247 1612 3185 2654 M12445 GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH.html Any process that controls the length of actin filaments in a cell. 167/207 Gene Ontology BP GO:0030832 0.266148747159514 0.315352717222618 3930 2635.54545454545 2498 0.0277397080872006 1545 1.03294547256275 -1.05292652196116 -1 1.75938036314887 3926 2008 3028 1545 2210 2538 3823 3709 1962 1744 2498 2655 M12974 GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 31/43 Gene Ontology BP GO:0071377 0.0941897861590527 0.127180811084757 3915 2617.81818181818 2499 0.00895290662464312 927 1.28017845469963 -1.42390389641883 -1 3.9091610669184 3912 998 1502 2499 3851 3342 2427 3630 1895 927 3813 2656 M16687 GO_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a cell of a different type via adhesion molecules. 26/46 Gene Ontology BP GO:0034113 0.10292670526753 0.137067704008394 3935 2796.90909090909 2500 0.00982574600824977 1024 1.44162558467347 -1.43455624414725 -1 4.24324761865351 3935 1024 1269 1988 2440 4157 3732 3238 2500 1981 4502 2657 M16086 GO_BASEMENT_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. 28/31 Gene Ontology BP GO:0071711 0.0149070573932662 0.0281618100084725 100 2362 2501 0.00136445776034905 96 1.20128533407847 1.34253320870887 1 6.35678495859432 96 3127 858 2730 2312 2340 2335 2653 4463 2567 2501 2658 M10315 GO_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACTIVATION_CASCADE.html A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. 51/269 Gene Ontology BP GO:0072376 8.14223676844965e-10 3.50794700774039e-08 3435 2383.90909090909 2502 7.40203342860281e-11 78 1.93552807731367 1.6759701742329 1 49.3222151724525 3431 1572 78 1957 414 4641 3919 4293 2502 216 3200 2659 M13915 GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT.html Any apoptotic process that is involved in anatomical structure development. 27/38 Gene Ontology BP GO:1902742 0.579279141278329 0.626833917294899 2505 2528.09090909091 2502 0.0756900239595643 1674 1.20151805011083 1.28179148593039 1 0.82262003449311 2502 1674 2286 2709 3430 2598 2471 3322 1849 2505 2463 2660 M15603 GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. 22/24 Gene Ontology BP GO:0070861 0.00046192831799473 0.00231217983617779 4330 2285.90909090909 2503 4.20023033100737e-05 215 0.873909858933167 1.06377053340225 1 7.86525010440753 4327 347 3049 622 282 2503 1119 4572 215 3798 4311 2661 M16598 GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 29/39 Gene Ontology BP GO:0010922 0.116354675930716 0.152120906745047 2040 2683.27272727273 2503 0.0111824170833322 1583 1.07530306351744 1.36481069044001 1 2.99594172765269 2038 2726 2503 3116 4639 2010 1583 1700 3808 3055 2338 2662 M13905 GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a neurophysiological process. 27/34 Gene Ontology BP GO:0031646 0.00151753727449286 0.00537783772902916 1540 2347.72727272727 2504 0.00013805318800261 465 1.36400414576499 1.32659301907502 1 10.5725538820379 1536 3119 1286 3275 465 3038 3563 917 4150 2504 1972 2663 M11708 GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/16 Gene Ontology BP GO:0032239 0.0820936193723774 0.113246845816683 1190 2538.09090909091 2505 0.00775701923652705 1187 0.949563395052411 0.949563395052411 1 3.06044837116865 1187 3569 3469 3564 1655 1470 1630 2250 2812 3808 2505 2664 M14434 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. 26/34 Gene Ontology BP GO:0060045 0.0510649328874206 0.0759487921311739 4500 2516.18181818182 2506 0.00475365681554249 308 1.27399474297074 1.44385004213576 1 4.86547600208102 4496 308 1099 665 3739 4253 4589 2506 433 1526 4064 2665 M15618 GO_DORSAL_VENTRAL_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 24/35 Gene Ontology BP GO:0009950 0.0316622760046495 0.0512316754520936 1995 2393.54545454545 2506 0.00292066871761131 714 1.20516669613347 1.0505935487429 1 5.30655654582645 1993 3487 2506 4228 1295 2367 1370 2948 714 2691 2730 2666 M13184 GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 13/16 Gene Ontology BP GO:0010870 0.00486453714467887 0.0123427510190973 2530 2173.18181818182 2508 0.000443211527018034 149 0.831591289665224 -0.655279993795918 -1 5.41577150815167 2528 1822 3042 2465 2508 864 149 3459 3372 3286 410 2667 M15641 GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 137/250 Gene Ontology BP GO:0050777 0.00143748451942342 0.00515698956736867 1345 2319.18181818182 2508 0.000130765875896052 537 1.15429326153518 1.25400057009391 1 9.01729207369283 1344 2033 537 3045 3403 2861 2508 1948 4044 596 3192 2668 M11676 GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION.html Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. 38/49 Gene Ontology BP GO:0097035 0.0929656192136469 0.12583788134706 2510 2693 2510 0.00883122124474609 1564 1.06341889175658 1.29143197013346 1 3.2622188900498 2506 2680 2185 2510 4373 3150 1678 1564 4133 1754 3090 2669 M12767 GO_POSITIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIVISION.html Any process that activates or increases the frequency, rate or extent of cell division. 126/192 Gene Ontology BP GO:0051781 0.0853053363653438 0.11705270719786 3240 2482.18181818182 2511 0.00807314212337489 11 1.30148865003227 -1.39635453082626 -1 4.13478003082268 3240 11 1222 3721 3906 2940 4172 2511 1749 1824 2008 2670 M13277 GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. 34/50 Gene Ontology BP GO:0071825 0.0623635565058795 0.0897229446119802 4625 2813.63636363636 2511 0.00583680762709321 976 1.49428812651968 1.31288128327341 1 5.33884060173791 4621 976 1144 2511 2141 4313 4070 4231 1630 1443 3870 2671 M14045 GO_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 273/420 Gene Ontology BP GO:0006631 9.45790460068978e-06 0.000122243416963915 4575 2367.09090909091 2511 8.59813205537824e-07 9 1.18341992692961 -1.07878285373813 -1 15.8206204066408 4574 650 256 9 2511 3675 4477 4629 1212 220 3825 2672 M11209 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html The directed movement of a protein to a specific location in the endoplasmic reticulum. 126/216 Gene Ontology BP GO:0072599 0.0191064786496567 0.0343127230003976 370 2763.36363636364 2512 0.00175222362736499 368 0.643118832862069 0.584363444785452 1 3.20956295233754 368 4342 4196 4114 1108 1260 958 2497 4621 4421 2512 2673 M12279 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE.html Any process that modulates the size of an anatomical structure. 492/671 Gene Ontology BP GO:0090066 6.0257227143074e-10 2.64506488581814e-08 2515 2175.45454545455 2512 5.47792974177984e-11 40 1.23542083576546 1.22082446189067 1 31.995744937563 2512 1333 76 709 2844 3657 3095 3710 1861 40 4093 2674 M11621 GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). 48/58 Gene Ontology BP GO:0007223 0.43119990772354 0.48137552078638 3210 2422.81818181818 2513 0.05 193 1.04200286631317 -0.984293408488681 -1 1.12050482724972 3206 193 2513 437 3273 2451 2448 3892 1304 2768 4166 2675 M12121 GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 31/43 Gene Ontology BP GO:0010743 0.00176236851241117 0.00599081320354359 2715 1992.54545454545 2515 0.000160343808177118 301 1.65375771837648 1.6276373126571 1 12.5556785283607 2715 301 555 791 2771 2786 2515 3598 1276 926 3684 2676 M14712 GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT.html The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. 13/16 Gene Ontology BP GO:0072531 0.314248166676092 0.366465343244075 2115 2608.36363636364 2516 0.0337131066254813 1788 1.20678475050648 1.43587072777149 1 1.78810851404316 2113 2871 2492 2516 3971 2437 1788 2805 3170 2704 1825 2677 M14914 GO_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 60/70 Gene Ontology BP GO:0010332 0.0624945780859879 0.0898323360624349 3355 2508.72727272727 2516 0.00584943755684237 1232 1.19044662854432 -1.13265484238664 -1 4.24894404770732 3351 2625 2217 2635 1535 3231 3326 2418 1232 2510 2516 2678 M16750 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. 28/47 Gene Ontology BP GO:0002483 0.175557689194702 0.217310435707089 655 2850.63636363636 2516 0.0173967267224839 655 0.745890825974663 -0.744934993426437 -1 1.67988883015299 655 4472 3303 4052 2015 1382 2209 2516 4640 3987 2126 2679 M16329 GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 370/682 Gene Ontology BP GO:0098660 9.96517672225225e-08 2.40248535174299e-06 3815 2238.90909090909 2519 9.05925197603406e-09 145 1.16333251388299 -1.15737326163589 -1 22.3395435239972 3814 627 145 1699 3485 1446 3578 4113 2519 660 2542 2680 M12642 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. 125/180 Gene Ontology BP GO:1903169 0.059147501211093 0.0858432074657566 3670 2638.27272727273 2521 0.00552729535421912 1131 1.03200931841255 -1.11051999968211 -1 3.75163383666011 3668 2043 1131 2380 2260 2827 4444 2521 3146 1998 2603 2681 M16716 GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. 63/88 Gene Ontology BP GO:0009185 0.004167267992593 0.0110928478086586 2810 2101.27272727273 2521 0.000379562061960354 532 1.03756878546237 -1.0371478422723 -1 6.92433800685237 2808 2619 3039 3464 680 532 1810 1662 2521 2661 1318 2682 M15418 GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. 49/55 Gene Ontology BP GO:2000249 0.0742820323421142 0.10395016435725 865 2697.36363636364 2522 0.00699231748894812 865 1.12999549593327 1.2379794396743 1 3.78773008501821 865 4381 2522 4465 3797 1864 1272 1463 4293 3129 1620 2683 M11776 GO_CRISTAE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRISTAE_FORMATION.html The assembly of cristae, the inwards folds of the inner mitochondrial membrane. 12/13 Gene Ontology BP GO:0042407 0.0732807873944418 0.102765371834339 660 2417.27272727273 2523 0.0068947268526479 656 0.539415599488489 -0.539415599488489 -1 1.81172255233825 656 2885 3836 2929 2014 1721 839 1925 2774 4488 2523 2684 M14100 GO_REGULATION_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. 1048/1431 Gene Ontology BP GO:0032880 0.261144904008336 0.310134568236546 2260 2846.09090909091 2523 0.0298119359820796 2138 1.06683326235169 1.08494195297955 1 1.84388093999383 2256 2436 4474 2138 3937 2795 2523 2201 2278 2980 3289 2685 M10913 GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. 13/16 Gene Ontology BP GO:0033240 0.0904781032226077 0.123052849826241 2860 2156.54545454545 2524 0.0085844149199227 500 0.804949894594115 -0.731283449386827 -1 2.49347897725099 3570 500 2857 616 2825 2054 2857 1546 2524 3277 1096 2686 M12706 GO_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_REMODELING.html The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. 61/78 Gene Ontology BP GO:0046849 0.267355535271712 0.316460265993202 2460 2561.90909090909 2524 0.0278851661143397 1165 1.27676104252254 1.12009443696118 1 2.17053335865885 2460 1543 1572 1165 3664 3513 3404 3221 3448 1667 2524 2687 M13369 GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 13/20 Gene Ontology BP GO:0050857 0.0057037877375238 0.0134540021460564 1780 2474.63636363636 2524 0.000519875404724397 761 0.877926837856031 0.931212460903001 1 5.6057497968251 1779 2359 1960 2843 761 2900 2524 1259 4609 3288 2939 2688 M10562 GO_REGULATION_OF_PODOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PODOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of podosome assembly. 22/27 Gene Ontology BP GO:0071801 0.257998728921541 0.306897688535401 2605 2516.18181818182 2525 0.0267630153944863 1262 1.02944306156236 -1.14497542046127 -1 1.79492050872912 2604 2272 2690 1906 2190 2859 3455 2318 1262 2525 3597 2689 M11292 GO_HORMONE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_TRANSPORT.html The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 72/118 Gene Ontology BP GO:0009914 0.117253621895664 0.153210082190543 2665 2472.81818181818 2525 0.0112739084273018 1011 1.22825260284662 1.14402757214833 1 3.41058538556073 2665 1515 1307 1517 3425 3154 2172 3685 2525 1011 4225 2690 M12847 GO_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_VACUOLE.html A process in which a protein is transported to, or maintained at, a location in a vacuole. 59/61 Gene Ontology BP GO:0072665 0.00579228715277075 0.0134757560609211 2085 2727.72727272727 2525 0.000527963079231061 465 0.757353452750295 0.784809046062931 1 4.83258183845646 2085 2131 3881 2444 764 2727 2525 4334 4472 4177 465 2691 M16413 GO_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized. 194/279 Gene Ontology BP GO:0048705 1.14139297220349e-06 1.91210052393573e-05 2610 2151.45454545455 2525 1.03763051306881e-07 210 1.28498620675037 1.34605960692063 1 20.719077283607 1535 2525 210 2608 2102 3267 2608 2339 3133 527 2812 2692 M11126 GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. 13/20 Gene Ontology BP GO:2000311 0.00741839477225481 0.0163513931195176 2960 2497.72727272727 2526 0.000676684392042195 745 1.70373220486 -1.56479215777876 -1 10.3953285511699 2959 3578 745 2526 2990 1386 1103 4238 3795 2094 2061 2693 M11508 GO_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_CYCLE.html Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 22/27 Gene Ontology BP GO:0042634 0.01598496000874 0.0297512075682669 2065 2700.36363636364 2526 0.00146384548624302 1055 1.13500484942996 1.10959490826522 1 5.9129360366038 2065 3151 2203 3929 1055 1970 2120 4518 3608 2526 2559 2694 M12102 GO_CELLULAR_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 17/23 Gene Ontology BP GO:0071318 0.00849834112681562 0.0181638866619536 3305 1943.90909090909 2526 0.000775577078062654 466 1.30546952630091 -1.31495728004648 -1 7.75906574134668 3305 466 2526 1066 1473 2715 3274 588 2693 2553 724 2695 M15761 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 184/249 Gene Ontology BP GO:0007163 0.215579785945631 0.260205640468228 2075 2582.90909090909 2526 0.0218318332457456 1350 0.99756413021842 0.933496768996374 1 1.983469371354 2072 2526 3041 1350 2113 2363 1805 3741 2659 3415 3327 2696 M11671 GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. 22/28 Gene Ontology BP GO:0044788 0.00120667226529042 0.00453159487521898 1680 2380.81818181818 2527 0.000109757692589177 425 1.62708527761487 1.74470122139023 1 13.0274225587402 1677 3503 2601 4155 425 3562 3214 1895 611 2527 2019 2697 M14115 GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 16/23 Gene Ontology BP GO:0014733 0.43119990772354 0.48137552078638 3190 2393.45454545455 2527 0.05 409 1.04636248199171 -0.943597223762658 -1 1.12523749738517 3186 461 2202 409 2527 3571 4239 3258 933 2448 3094 2698 M13236 GO_RELAXATION_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_MUSCLE.html A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. 28/37 Gene Ontology BP GO:0090075 0.040381141827362 0.0626520349859005 2535 2471.18181818182 2531 0.00374017859636259 1011 1.04791390793705 -0.971312819362058 -1 4.29963279276129 2531 1011 1045 2784 2456 3314 1862 3945 3127 2170 2938 2699 M16035 GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION.html Any process that modulates the frequency, rate or extent of protein polyubiquitination. 16/20 Gene Ontology BP GO:1902914 0.347837280334026 0.400219304004506 3065 2416.81818181818 2531 0.0381147393513134 50 1.23175596554608 -1.35718398906205 -1 1.66418307241991 3061 1145 2865 612 3471 4162 3896 2336 50 2456 2531 2700 M16186 GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycosyl compound. 34/46 Gene Ontology BP GO:1901658 0.0115977177173901 0.0231605925060156 940 2588.27272727273 2531 0.00105993748742425 690 0.979633734884122 -0.979633734884122 -1 5.46630768727498 940 4092 3489 3927 2531 1942 2016 690 3460 3633 1751 2701 M10200 GO_N_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_GLYCAN_PROCESSING.html The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. 17/20 Gene Ontology BP GO:0006491 0.00601875125626641 0.0138610792338377 3830 2235 2532 0.000548661879668499 342 0.950429875030875 -0.965355529100448 -1 6.02751151855222 3828 428 2532 342 782 2853 2314 3084 925 3066 4431 2702 M13042 GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. 18/21 Gene Ontology BP GO:0009200 0.0126296516382395 0.0247122662206595 1900 2297.36363636364 2532 0.00115479485834939 457 0.925886340133822 -0.962154635243464 -1 5.07666359707455 1897 3177 3218 2532 976 1865 1624 3063 457 3146 3316 2703 M13776 GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT.html The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. 37/41 Gene Ontology BP GO:0043001 0.00511426944474798 0.0128280891379529 3060 2344.18181818182 2532 0.000466017932772821 229 0.866952628069142 -1.03033222252227 -1 5.59686894626009 3057 939 3588 1333 741 1839 3159 4636 229 3733 2532 2704 M11284 GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. 11/16 Gene Ontology BP GO:0043922 0.0196172015928866 0.0349727352535254 2110 2803.72727272727 2533 0.00179948561411995 712 0.563573902853375 0.414364922665905 1 2.7953220576724 2108 3939 3254 3661 1119 2236 712 2268 4542 4469 2533 2705 M16209 GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. 53/70 Gene Ontology BP GO:2000677 0.458024186927197 0.507425367088631 2460 2893.45454545455 2533 0.0541628781149512 1096 1.49476376181685 1.7630473079579 1 1.49503825973589 2458 4367 2100 4028 4498 3113 2454 2533 1096 2116 3065 2706 M15242 GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. 20/29 Gene Ontology BP GO:2000178 0.316251287457429 0.368599199746718 3170 2507.36363636364 2534 0.0339700461340949 1196 1.04440368104978 0.943874075802803 1 1.53706805013563 3167 2283 2737 2220 2534 2295 2847 2267 1196 2830 3205 2707 M15779 GO_LYMPH_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. 22/28 Gene Ontology BP GO:0001945 0.194103162733745 0.237486725269555 3360 2744.36363636364 2534 0.0194269563875339 1395 1.1371236507968 1.15569154591345 1 2.41670536801437 3359 3815 2327 3284 2257 2699 1395 2452 3824 2534 2242 2708 M13573 GO_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 151/182 Gene Ontology BP GO:0009411 0.00179096508282621 0.00605182318837355 2610 2512.45454545455 2535 0.000162947702420724 493 0.922020455523719 -0.919667916296184 -1 6.98158473928505 2606 2535 3466 2216 493 2027 1279 1911 3351 3982 3771 2709 M11976 GO_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE.html Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. 968/1913 Gene Ontology BP GO:0006952 1.8725902993197e-11 1.26277719749776e-09 1815 2676.45454545455 2539 1.87259029933547e-12 24 1.35015353848023 1.41722457049638 1 41.0665376861322 1815 2439 4336 3195 3919 3169 2539 2372 2389 24 3244 2710 M11956 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. 370/470 Gene Ontology BP GO:0032970 0.00101265829631946 0.0040135426343905 2265 2410.63636363636 2540 9.21022475227956e-05 344 1.11788379452647 1.10087798362277 1 9.1486198455521 2264 1354 716 1234 2971 3768 3247 3932 2540 344 4147 2711 M16065 GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. 24/26 Gene Ontology BP GO:0016601 0.00577426225782821 0.0134540021460564 4505 2650.72727272727 2540 0.000526315789473684 15 1.30168636619 -1.60093073283502 -1 8.31669132802356 4503 1035 2540 155 2320 3967 4284 4626 15 1786 3927 2712 M11802 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 1695/2327 Gene Ontology BP GO:0010628 0.118618071884246 0.154775627727818 860 2619.90909090909 2541 0.0125470442018245 857 1.08108012150009 1.10365949610235 1 2.98432299677451 857 3614 4325 4146 3695 1563 1308 1769 2541 2814 2187 2713 M12535 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. 47/88 Gene Ontology BP GO:0032735 0.132222394228204 0.170047208497466 1555 2696.27272727273 2542 0.0128099551939018 1014 0.985962212785739 -0.947397395961727 -1 2.58305123487986 1551 3375 2281 3123 4392 1014 2542 2481 3673 3039 2188 2714 M16624 GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of cation transmembrane transport. 207/316 Gene Ontology BP GO:1904062 0.000131752541951328 0.00093451917332245 3140 2635.90909090909 2542 1.19782211768913e-05 364 1.09566789695379 -1.20610791255249 -1 11.337607375114 3136 1974 364 1787 2460 4389 3448 4029 2542 1061 3805 2715 M12280 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. 10/15 Gene Ontology BP GO:1901722 0.0171874588877786 0.031535191721149 1520 2507.36363636364 2543 0.00157483844048363 338 0.845416938477907 0.744193843509429 1 4.32847290566795 1519 3933 2969 3578 2543 1913 338 2297 4366 3018 1107 2716 M13223 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 33/44 Gene Ontology BP GO:0030947 0.013677220102704 0.0263084353608441 2205 2532.72727272727 2543 0.00125118161623939 1000 1.28410753245197 1.46982307023649 1 6.92558791175465 2202 2214 1322 2618 1000 3910 2774 2265 3966 2543 3046 2717 M15528 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. 26/55 Gene Ontology BP GO:0046638 0.0538635372373399 0.0794884360181866 1700 2584.63636363636 2543 0.00502085026730283 722 1.25452205740024 -1.31150246848916 -1 4.70609296203026 1696 4136 2688 4013 1694 1972 2543 1903 3801 3263 722 2718 M13021 GO_LYSOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_LOCALIZATION.html Any process in which a lysosome is transported to, and/or maintained in, a specific location. 25/47 Gene Ontology BP GO:0032418 0.366274845107987 0.419256298717704 3860 2454.72727272727 2544 0.0406192609927847 1031 1.00269179603611 -0.91324421198592 -1 1.28353402152742 3860 1031 2109 2544 2817 1680 2237 2701 2710 2340 2973 2719 M14819 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. 55/70 Gene Ontology BP GO:1903201 0.26405019427237 0.313105390914714 1225 2751 2544 0.0274872798761728 1225 0.857772973877246 0.925126349514533 1 1.4683158495692 1225 3037 3250 3834 2544 2087 2091 2160 4153 3824 2056 2720 M12540 GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. 21/22 Gene Ontology BP GO:0031061 0.0182082494997913 0.0329918165586171 2545 2375.81818181818 2545 0.00166915629903585 343 0.955991096279209 -1.05965146651244 -1 4.83190169525859 2545 3833 3746 4202 2906 1273 1042 1507 661 4076 343 2721 M12995 GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of cell junction assembly. 44/50 Gene Ontology BP GO:1901890 0.00984673493537996 0.0203630478463658 250 2186.36363636364 2545 0.000899189544686579 248 1.26359212664883 1.16877583335498 1 7.29539856279581 248 3383 791 3448 2824 1469 1277 2559 3959 2545 1547 2722 M15806 GO_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLIC_PROCESS.html The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. 34/78 Gene Ontology BP GO:0019748 0.00448157757005946 0.0116430934860339 2550 2406.18181818182 2546 0.0004082484569566 707 1.55223528580066 -1.73724725108518 -1 10.2527331661046 2546 3094 1311 2993 707 2271 3665 3577 3680 1445 1179 2723 M12311 GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. 28/50 Gene Ontology BP GO:0000060 0.324838754431891 0.377396934924242 2550 2580 2547 0.0350793706385715 1667 0.831088564361045 -0.899443383932891 -1 1.19184272224828 2547 1667 2746 2650 2452 1790 1754 3479 4041 3389 1865 2724 M14271 GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION.html The modification of a protein by cis-trans isomerization of a proline residue. 35/41 Gene Ontology BP GO:0000413 0.476169069508284 0.52614929480457 2290 2757.27272727273 2547 0.0570863524388227 2174 0.830848602880353 -0.790467248683784 -1 0.781562771593734 2289 2205 3520 2599 2547 2174 2631 3418 2285 4121 2541 2725 M14743 GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. 78/129 Gene Ontology BP GO:0002702 0.0299669269057728 0.0491572576675048 2285 2742 2548 0.00276209765065693 1021 1.05342006933821 1.05164792953794 1 4.70169921504854 2282 4013 2548 4059 2007 2565 1907 1021 3875 2297 3588 2726 M14939 GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. 15/15 Gene Ontology BP GO:0043558 0.00251643214457667 0.00765791940399951 2330 2728.36363636364 2548 0.000229028649088461 560 0.674276091079597 0.690334246126499 1 4.86712728543902 2327 2345 3705 2863 560 2461 2548 3992 1545 4589 3077 2727 M15067 GO_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that modulates the frequency, rate or extent of translational initiation. 89/99 Gene Ontology BP GO:0006446 0.00801288279782342 0.0173817919152785 635 2530 2548 0.000731110651266352 634 0.730683185825778 0.684597445088245 1 4.3858756322438 634 3680 4151 3860 851 1414 1151 2548 3040 4298 2203 2728 M15754 GO_RESPONSE_TO_MERCURY_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MERCURY_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. 13/20 Gene Ontology BP GO:0046689 0.145556111162335 0.184492668275224 2710 2504.63636363636 2548 0.0141986389009165 1194 1.17555241169865 -0.725862283584727 -1 2.93947866556124 3021 2364 2289 2548 4516 1512 1194 2708 1243 2706 3450 2729 M15184 GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. 47/59 Gene Ontology BP GO:0030834 0.00577426225782821 0.0134540021460564 2550 2179.45454545455 2549 0.000526315789473684 139 1.09820094534386 1.10569059695801 1 7.01492218424998 2549 188 2499 139 3322 3067 2935 4167 1007 700 3401 2730 M15831 GO_PEPTIDYL_ASPARAGINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ASPARAGINE_MODIFICATION.html The modification of peptidyl-asparagine. 35/40 Gene Ontology BP GO:0018196 6.84032359407379e-06 9.27930777936599e-05 3610 2637.81818181818 2549 6.21849532941855e-07 20 1.10919928826033 1.34116314755638 1 15.2817037426474 3606 1633 2549 2292 20 4188 4606 2177 444 3046 4455 2731 M15552 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 89/127 Gene Ontology BP GO:0051279 0.0813795503522303 0.11236173524894 3560 2629.81818181818 2550 0.00768687150471138 804 0.98544237715299 -1.0140891856229 -1 3.1879704915602 3559 804 1270 2371 1650 2439 4362 3156 2689 2550 4078 2732 M16403 GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. 22/29 Gene Ontology BP GO:0048384 0.00121854474917657 0.00457249090154725 3130 2566.36363636364 2551 0.000110838200492771 426 1.29074379156501 -1.63298652913839 -1 10.3150478867158 3126 4484 2551 3923 426 2109 4232 2727 773 2535 1344 2733 M11966 GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 12/24 Gene Ontology BP GO:0045723 0.0103003043968863 0.0211506250479752 3465 2492.09090909091 2553 0.000940804406160745 915 1.02313703976316 1.26176698703048 1 5.84744327320931 3461 2384 2461 1559 915 2553 2699 1509 4339 2578 2955 2734 M16510 GO_ERYTHROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. 26/33 Gene Ontology BP GO:0048821 0.468304824313841 0.51770547577389 3800 2478.27272727273 2553 0.0558081503266233 522 1.01401103750298 0.752858303807781 1 0.980569560929236 3800 1019 2256 974 4289 3378 2553 3074 522 1528 3868 2735 M16724 GO_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_SELECTION.html The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. 29/47 Gene Ontology BP GO:0045058 0.15763770789242 0.198132969968511 3610 2873.63636363636 2553 0.0154740349636031 1074 1.39471827795845 1.19797989200829 1 3.34177678971832 3607 4120 1469 2607 2497 2460 2222 4350 2553 1074 4651 2736 M12727 GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 53/61 Gene Ontology BP GO:0010660 0.0014671963018678 0.00523934335578733 4295 2153 2555 0.000133470518228265 159 1.32433300836585 -1.35143738513137 -1 10.316052217885 4291 159 538 219 2555 4176 3443 3843 1053 495 2911 2737 M15335 GO_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERTILIZATION.html The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). 107/221 Gene Ontology BP GO:0009566 0.439139776053979 0.48918299688273 2935 2550.36363636364 2555 0.0512132659904522 1803 1.20155660103697 -1.12917264000401 -1 1.2650072012642 2934 2058 2133 1826 3528 2555 3397 2626 1803 3031 2163 2738 M10846 GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 101/144 Gene Ontology BP GO:0071482 0.000433930872734407 0.00220423619086593 2040 2131.90909090909 2556 3.9456044133474e-05 50 0.984254486698982 0.969405800579147 1 8.92957732524221 2037 50 2776 2556 278 1248 709 3797 3781 3032 3187 2739 M11758 GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. 122/154 Gene Ontology BP GO:1903650 0.00913947838707101 0.0192705833805918 1945 2468.36363636364 2556 0.000834333536473105 883 1.06950635659264 1.18704531622313 1 6.26076662478373 1942 2556 3196 3172 883 3313 2663 1225 2370 3861 1971 2740 M14173 GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 17/18 Gene Ontology BP GO:0070498 0.155119724294455 0.19544329194208 2600 2530.27272727273 2556 0.015206857943197 808 0.827927648705153 0.944277097007246 1 1.99620298972123 2596 2330 3229 2648 1945 3618 2556 2054 808 3536 2513 2741 M16832 GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 18/26 Gene Ontology BP GO:0043518 0.000840270118563414 0.00351211480652927 2560 2289.54545454545 2556 7.64173839868506e-05 204 1.12320619729302 1.33576391822137 1 9.41480232312228 1051 4172 2556 3337 371 1008 204 2558 4183 3602 2143 2742 M16440 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. 82/112 Gene Ontology BP GO:1901019 0.333952236803257 0.385865348359959 1585 2616 2557 0.0362707641512747 1584 0.939951055626495 0.941706817595988 1 1.31838510798935 1584 2596 2079 1939 3351 2557 2160 3811 4079 2728 1892 2743 M14324 GO_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. 358/578 Gene Ontology BP GO:0022407 1.17849596819942e-07 2.74177087001594e-06 2420 2206.27272727273 2558 1.07136002848099e-08 120 1.27233228884546 1.24454790162482 1 24.1841083366541 2417 1359 151 966 3545 2558 2811 3707 2715 120 3920 2744 M16820 GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. 20/23 Gene Ontology BP GO:1900025 0.125239560986434 0.162368257807155 2835 2507.63636363636 2558 0.0120904266499204 1747 1.0756009087382 -0.918155901993619 -1 2.89265849261996 3065 2795 2558 2832 2399 2129 2975 1747 2422 2833 1829 2745 M11940 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. 103/126 Gene Ontology BP GO:0048640 0.000200393240173082 0.00126688824256162 2750 2429.18181818182 2560 1.82192268988938e-05 390 1.46098836977351 1.46282244731518 1 14.4612821569693 2750 3319 390 2560 1532 4399 3545 3712 1473 802 2239 2746 M10349 GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION.html A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. 65/78 Gene Ontology BP GO:0061572 0.00350226606372396 0.00983466746801907 3155 2249.90909090909 2561 0.000318895810525443 362 1.13477649782083 -1.0724027936192 -1 7.77691010153921 3155 850 2561 1041 633 3469 3307 3175 362 1908 4288 2747 M12740 GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 23/55 Gene Ontology BP GO:0032689 0.071126439611674 0.100470954314851 3640 2849 2561 0.00668506869075827 1583 1.08460116287363 1.06373629055318 1 3.68996489681406 3640 2262 1709 2561 1583 4613 3196 4002 2429 1678 3666 2748 M15566 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 53/65 Gene Ontology BP GO:0010596 0.0470402318728894 0.0708343685775256 2565 2533.18181818182 2561 0.00437065641798714 786 1.3297684794158 1.40606120635253 1 5.21659754667233 2561 3724 1440 3326 2171 3217 3873 1663 2448 786 2656 2749 M11687 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 30/47 Gene Ontology BP GO:0048147 0.404595097463021 0.456051596050251 4055 2670.90909090909 2562 0.0460438754925479 907 0.932364405158889 -0.809565204740148 -1 1.07630005026642 4053 1651 3099 907 2464 2562 4016 2777 3467 2301 2083 2750 M16685 GO_GLYCOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. 17/26 Gene Ontology BP GO:0016137 0.0263567054543626 0.0445146099742828 1405 2465.36363636364 2562 0.00242526063563845 1215 1.56751545179427 -1.30335710972969 -1 7.23235370175728 1405 3184 1975 1542 1215 2645 3584 4321 2867 2562 1819 2751 M13350 GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 61/86 Gene Ontology BP GO:0050922 2.35778823445224e-07 5.00949253648688e-06 3650 2207.54545454545 2563 2.14344407921965e-08 167 1.59234187993707 1.81564181246423 1 28.8443656356519 3647 856 167 475 4425 2945 4297 2563 1419 258 3231 2752 M14489 GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 61/109 Gene Ontology BP GO:0010830 0.291134497911476 0.342255891556872 4285 2991.09090909091 2563 0.030796676596093 1273 1.2343312101983 -1.10941648791057 -1 1.95442915901818 4282 2126 2043 1855 2256 3776 4350 3792 1273 2563 4586 2753 M14537 GO_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. 191/208 Gene Ontology BP GO:0007033 0.00325202208809622 0.00930034343940487 4330 2576.54545454545 2563 0.000296076288402419 609 0.86286033157568 -0.876550068821918 -1 5.98241572908658 4330 1988 4057 1012 609 2563 3821 2847 1342 4142 1631 2754 M12693 GO_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PAIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 28/52 Gene Ontology BP GO:0048265 0.00140611313285073 0.00508759285159755 1125 2429.09090909091 2565 0.000127910240387654 216 1.46698292414988 1.32121411159043 1 11.4924104177128 1122 3117 866 4507 2004 3147 2971 216 4117 2565 2088 2755 M13467 GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 23/35 Gene Ontology BP GO:0043949 0.00232705988401413 0.00723946109628236 2385 2341 2565 0.000211774999391556 77 1.41067759703 -1.41067759703 -1 10.3120435828961 2381 3486 2565 4130 1031 2669 3622 488 1822 3480 77 2756 M14883 GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. 33/44 Gene Ontology BP GO:0038083 0.121421341344324 0.158123006234295 1390 2655.09090909091 2565 0.0116991930353423 1386 0.895870392783026 1.07534520132422 1 2.44276230683775 1386 1637 2863 2711 3441 2560 2544 1730 4186 3583 2565 2757 M13913 GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/47 Gene Ontology BP GO:0051954 0.00071724802580731 0.0031475773195708 2945 2328.36363636364 2566 6.5225633737085e-05 145 1.47880879634748 -1.21334311778299 -1 12.6394921404354 2941 2724 1566 3201 1323 3973 4149 145 1284 2566 1740 2758 M14145 GO_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT.html Any process that modulates the frequency, rate or extent of protein import. 242/325 Gene Ontology BP GO:1904589 0.0293373063078801 0.0484237269423788 1000 2337.90909090909 2566 0.00270327150686886 708 1.02253409869691 1.11320518323411 1 4.58636097175408 996 2954 3141 3666 4456 1067 1510 1013 2566 3640 708 2759 M14421 GO_KETONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 24/38 Gene Ontology BP GO:0042181 0.000380855325964312 0.00200025261221394 1505 2674.09090909091 2566 3.462920673824e-05 263 1.11978221145541 -1.12644077527346 -1 10.3220703954127 1501 4143 2331 3953 263 1826 2566 2946 4421 3527 1938 2760 M14918 GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. 16/34 Gene Ontology BP GO:0022400 0.0134583726176025 0.0259841526098359 1765 2417.63636363636 2566 0.00123103777486028 282 0.800078194449195 0.85001729327668 1 4.32578349804591 1763 2834 3586 2652 4540 1358 282 1628 1467 3918 2566 2761 M10906 GO_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_SECRETION.html The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. 37/51 Gene Ontology BP GO:0030073 0.0261192348307084 0.0441937453335586 1445 2367 2567 0.00240314422569265 442 1.16691464541866 1.25519212130729 1 5.39383256352008 1441 3757 2567 3542 2727 1758 442 1142 3702 3164 1795 2762 M16665 GO_NEUROTROPHIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. 31/34 Gene Ontology BP GO:0038179 0.0082777809720248 0.0178234682382376 3955 2607.45454545455 2567 0.000755372022045943 860 0.879987941369252 -0.902867550613284 -1 5.25145886685082 3952 3108 3296 2210 860 1640 2567 2527 3610 2777 2135 2763 M12031 GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that activates or increases the frequency, rate or extent of translational initiation. 21/25 Gene Ontology BP GO:0045948 0.0396225868844152 0.0618048597965753 1665 2702.63636363636 2568 0.00366861169651581 1156 0.861307664100027 -0.920847482588821 -1 3.5494922257389 1663 3838 3694 3648 2261 1856 1745 1156 3558 3742 2568 2764 M16359 GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosyl compound. 112/135 Gene Ontology BP GO:1901659 0.0570236181807639 0.0834111585649464 675 2605.90909090909 2568 0.00532342033290925 617 0.708180385269453 -0.684005455844463 -1 2.60130329593229 672 3316 4135 4008 3889 617 1283 1915 2568 4312 1950 2765 M13316 GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 18/43 Gene Ontology BP GO:2000516 0.00577426225782821 0.0134540021460564 4050 2849.54545454545 2569 0.000526315789473684 223 1.30962419548716 1.18589194928675 1 8.36747246607566 4047 2311 1783 223 3309 4025 2569 4549 2392 1599 4538 2766 M14129 GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. 282/476 Gene Ontology BP GO:0072507 1.08152253792549e-10 6.13698093776501e-09 2610 2256.45454545455 2569 9.83202307253328e-12 57 1.27546066142701 -1.196758478278 -1 35.7998729586365 2608 1372 57 1459 3952 4539 3194 1837 3066 168 2569 2767 M16018 GO_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. 253/386 Gene Ontology BP GO:0042692 0.000864977508452528 0.00358982124712795 1715 2348.90909090909 2569 7.86652527593662e-05 489 1.15262953931997 1.21390795423472 1 9.62425675767546 1713 3965 489 2800 2978 2928 2020 2569 3480 1303 1593 2768 M11618 GO_CRANIAL_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 57/92 Gene Ontology BP GO:0021545 0.0931651194476539 0.125980035103148 2565 2901.54545454545 2571 0.00885104190018088 1245 1.20656345228385 1.29047880559675 1 3.70075185417279 2562 2135 1245 2927 2571 4206 2215 4643 3323 1728 4362 2769 M12745 GO_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. 41/43 Gene Ontology BP GO:0031440 0.000806552767398711 0.0034111851761443 1935 2536 2571 7.33498739557839e-05 366 0.717346253733196 0.635706785615938 1 6.04005749108861 1932 2678 3899 3766 366 1645 1398 3029 2571 4069 2543 2770 M11301 GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0033865 0.00774677175444782 0.016875341279703 2925 1989.81818181818 2572 0.000706744126309355 304 0.970849979590039 -0.768208231522697 -1 5.87359122618735 2924 304 2882 821 839 2648 2572 2762 946 3115 2075 2771 M12726 GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 36/52 Gene Ontology BP GO:0051491 0.0103154400901212 0.0211723611554186 1975 2472.81818181818 2572 0.000942193400371674 916 1.00761289855923 1.07611155777737 1 5.75702099641698 1972 1629 2310 2572 916 2914 2717 1998 3864 2744 3565 2772 M13159 GO_CARNITINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARNITINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. 14/16 Gene Ontology BP GO:0009437 0.0115624850617305 0.0231200012858754 3925 2474.36363636364 2572 0.00105670042295531 949 0.689563977189261 -0.936202353050834 -1 3.84637161154809 3925 1805 3417 1111 949 2572 3778 3218 1182 3851 1410 2773 M11529 GO_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 32/54 Gene Ontology BP GO:0006584 0.0012446551086308 0.00465545033798965 2705 2458.63636363636 2573 0.000113214530308315 202 1.22195437385277 1.22871466883963 1 9.73212153210294 2705 2215 1724 2573 4201 3452 4632 202 3344 1312 685 2774 M12620 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0034032 0.00774677175444782 0.016875341279703 2925 1997.36363636364 2573 0.000706744126309355 305 0.970849979590039 -0.768208231522697 -1 5.87359122618735 2925 305 2883 822 840 2649 2573 2834 947 3117 2076 2775 M13130 GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0033875 0.00774677175444782 0.016875341279703 2930 1984.27272727273 2574 0.000706744126309355 306 0.970849979590039 -0.768208231522697 -1 5.87359122618735 2926 306 2884 823 841 2650 2574 2680 948 3118 2077 2776 M14364 GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 13/13 Gene Ontology BP GO:0009263 0.162275178665293 0.203138661912727 1720 2543.36363636364 2574 0.0159680111333977 785 0.80682441168054 -0.681116146330987 -1 1.89878463392986 1719 3571 3449 2158 3974 1837 1273 2574 785 3289 3348 2777 M15740 GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. 32/54 Gene Ontology BP GO:0009712 0.00172089064400142 0.00589205604601809 2710 2463.09090909091 2574 0.000156567112752573 237 1.22195437385277 1.22871466883963 1 9.30471122299205 2706 2216 1725 2574 4202 3453 4633 237 3345 1317 686 2778 M13221 GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. 37/44 Gene Ontology BP GO:0070911 0.00338946818302428 0.0095873528605544 2485 2880.63636363636 2575 0.000308609228859159 618 0.584881505451751 -0.582525169187189 -1 4.02529214954658 2483 4094 4025 4084 618 1031 1804 2575 4320 4537 2116 2779 M13822 GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. 60/84 Gene Ontology BP GO:1904888 0.252802072662316 0.301149012825846 4015 2781.72727272727 2575 0.0261453309631208 1542 1.23934268028168 -1.18307485207741 -1 2.19786924096246 4012 2624 1542 2575 2337 4166 3353 3977 2386 1586 2041 2780 M12558 GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids with a chain length of less than C6. 18/26 Gene Ontology BP GO:0046459 0.000165907956423284 0.00108728129751766 3115 1873.54545454545 2576 1.50836790284155e-05 16 0.879427672591779 -0.642444820000994 -1 8.90021821829256 3111 382 2542 264 182 2576 3216 3027 16 2644 2649 2781 M14209 GO_NEGATIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_T_CELL_SELECTION.html The process of elimination of immature T cells which react strongly with self-antigens. 10/20 Gene Ontology BP GO:0043383 0.0324072493415314 0.0522853436845164 4455 2341 2576 0.00299042813193617 636 1.15420866821564 -1.23869884276868 -1 5.04683894332759 4453 1239 1913 636 1302 2935 3287 3285 2576 1086 3039 2782 M15985 GO_RESPONSE_TO_FOLIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. 18/23 Gene Ontology BP GO:0051593 0.109609593457766 0.144602619324918 3275 2546 2576 0.0104986147051291 632 1.43057450781719 1.26736450764328 1 4.09696518771594 3271 3188 1969 2576 3134 3566 3907 1665 632 1604 2494 2783 M10559 GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cation channel activity. 39/56 Gene Ontology BP GO:2001259 0.493966704116695 0.544006408107688 2750 2645.72727272727 2577 0.0600447231806385 1603 1.03115658420176 -1.15657426685992 -1 0.921457402188111 2748 1603 1922 2045 2577 4340 3024 3678 2770 1860 2536 2784 M11060 GO_3_UTR_MEDIATED_MRNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_UTR_MEDIATED_MRNA_STABILIZATION.html An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. 16/16 Gene Ontology BP GO:0070935 0.146364484915618 0.185369540815235 2580 2437.09090909091 2577 0.0142834616257535 155 1.03580365661156 -1.12594327198421 -1 2.58147556867696 2577 2341 3143 2384 2784 1877 2690 4095 155 3498 1264 2785 M11344 GO_THYROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. 9/17 Gene Ontology BP GO:0042403 7.58882853533229e-05 0.000606715106097958 4550 2324.09090909091 2577 7.58908770422213e-06 127 2.12007879896111 -2.27368773781307 -1 23.3076719682072 4548 2909 4294 2256 127 2577 3323 697 901 931 3002 2786 M13157 GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). 29/36 Gene Ontology BP GO:0001941 0.0653737461605742 0.0932222007003224 1960 2465.09090909091 2577 0.00612738310653283 792 1.27944410156578 1.18170349266117 1 4.49702241305463 1958 2730 1498 2577 2044 3135 792 3316 3742 2241 3083 2787 M15082 GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. 482/608 Gene Ontology BP GO:0042326 0.108692396332362 0.14359617266737 2805 2475.09090909091 2578 0.0104059951543942 966 1.07928716838161 1.11436395049002 1 3.09950203919604 2804 1919 1868 3741 2246 2578 3054 3409 2975 966 1666 2788 M12858 GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 20/38 Gene Ontology BP GO:0051354 0.00096149306846066 0.00385674762719608 4280 2620.90909090909 2579 8.74466853543315e-05 173 0.975256966565922 -1.01418339271518 -1 8.03772597060872 4276 1734 2579 3567 668 4149 4263 173 2312 2355 2754 2789 M10954 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. 61/71 Gene Ontology BP GO:2001021 0.0328569163062348 0.0529557435306236 1730 2486.27272727273 2581 0.00303255864784031 1076 1.07338403804832 1.24942827246562 1 4.67237664684812 1727 3351 3270 3324 2873 2581 1482 1076 1930 3963 1772 2790 M12855 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. 14/14 Gene Ontology BP GO:0046929 0.0442748578137132 0.0672695983754418 2585 2403.27272727273 2581 0.00410834804719268 442 0.881751614591526 1.05519844432291 1 3.52306771717381 2581 3897 3392 1669 4286 1363 1535 1214 442 3360 2697 2791 M10368 GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. 69/129 Gene Ontology BP GO:0002821 0.00829655239656042 0.017847368608967 1745 2532 2583 0.000757091474066808 585 0.971944933796808 1.05640979338206 1 5.7994061993807 1743 3703 3386 3670 2382 1580 1532 585 3504 3184 2583 2792 M13213 GO_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE.html Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. 489/1073 Gene Ontology BP GO:0045087 2.83818758847474e-10 1.40012900082822e-08 2340 2513.63636363636 2583 2.58017053530991e-11 67 1.26763818367857 1.26987608133552 1 34.0277526343828 2336 2461 67 2477 4375 2754 2674 3940 2583 176 3807 2793 M13576 GO_SKIN_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. 89/111 Gene Ontology BP GO:0098773 0.00208877704400969 0.00670538755887721 2230 2451.45454545455 2583 0.000190069351015116 576 1.36914220919379 1.16217164956418 1 10.1639017711545 2229 2583 576 2857 3488 2948 1677 2278 3710 1539 3081 2794 M10448 GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that stimulates, induces or increases the rate of macrophage activation. 11/16 Gene Ontology BP GO:0043032 0.205118544377811 0.248869484355877 1875 2582.36363636364 2584 0.020653042067902 1229 1.65928735953574 1.57011939857686 1 3.41599987319232 1872 3590 1478 3973 2997 2970 2584 3866 1662 1229 2185 2795 M14329 GO_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE.html Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. 824/1745 Gene Ontology BP GO:0006955 4.65386893100979e-10 2.12298550352829e-08 1635 2593.18181818182 2587 4.65386893198443e-11 35 1.29666133182914 1.27888705879075 1 34.0056451002359 1631 2442 4487 1705 3887 2587 2394 3334 2649 35 3374 2796 M15432 GO_NEUTROPHIL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a neutrophil. 20/36 Gene Ontology BP GO:0002446 0.0143686004154594 0.0273556046371247 3125 2319.09090909091 2587 0.00131484650048451 814 1.37318099042271 1.25615481222644 1 7.32714464677745 3123 1724 2587 2370 1016 2930 2378 2816 814 2831 2921 2797 M11228 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. 91/151 Gene Ontology BP GO:0051153 0.395456848712909 0.44726804012182 2835 2772.18181818182 2589 0.0447220462693864 1176 1.25328870560226 1.34589262138598 1 1.48662884478069 2832 2589 1852 2401 3027 4469 4108 2429 1176 2166 3445 2798 M12647 GO_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BACTERIUM.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. 455/948 Gene Ontology BP GO:0009617 6.61374982649854e-13 6.9940404415222e-11 1820 2339.54545454545 2589 6.0124998422732e-14 29 1.28645755816563 1.26998353198713 1 44.6555812508562 1819 2465 29 1977 3546 2589 2669 3744 3190 39 3668 2799 M11491 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. 7/21 Gene Ontology BP GO:0002674 0.00520509654975401 0.0130001686774049 4240 2542.45454545455 2591 0.000521732875680703 762 1.04638818058204 -0.967728231266553 -1 6.73677176427538 4240 1249 4307 1838 762 3713 2936 1277 1008 2591 4046 2800 M15999 GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 586/759 Gene Ontology BP GO:0045936 0.104567952561361 0.138777719129496 2595 2601.54545454545 2591 0.0109841233589966 978 1.08662882710739 1.1138177185948 1 3.17572814832505 2591 2451 4584 3230 2622 1979 2762 2192 2980 978 2248 2801 M14556 GO_DIENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. 63/125 Gene Ontology BP GO:0021536 7.48959292192652e-05 0.000600846135615933 3800 2468.45454545455 2594 6.80895264256039e-06 336 1.54079069035956 -1.56949932224774 -1 16.958433191709 4284 2613 336 2594 1045 2195 3798 3798 2548 661 3281 2802 M16935 GO_ACTIVATION_OF_MAPKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). 63/76 Gene Ontology BP GO:0000186 0.0734616967941952 0.102988031088699 1170 2571.45454545455 2594 0.00691235286655088 840 0.907495529325091 0.992555940572428 1 3.05234352332531 1166 3350 3415 3631 2594 1757 840 2362 3142 3456 2573 2803 M11438 GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. 81/164 Gene Ontology BP GO:0030518 0.62405141237597 0.669704590763759 2230 2897.54545454545 2595 0.0850964466646134 1445 0.89143654019751 -0.871623311410045 -1 0.520005796533784 2230 2595 3894 2197 2940 2350 2809 4653 1445 4197 2563 2804 M13922 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). 202/264 Gene Ontology BP GO:0097193 0.129300669070934 0.166519793298382 3395 2320.45454545455 2595 0.0125082552232133 698 0.908527286660486 0.970664286321733 1 2.40762543935226 1952 698 3393 1365 3514 1109 1120 3393 2972 3414 2595 2805 M10706 GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization of an epithelial cell. 33/37 Gene Ontology BP GO:0090162 0.00303279076736248 0.00884183924845716 2790 2054.45454545455 2596 0.000276089061929197 258 0.996534373271859 0.870752312057211 1 6.98566901637794 2789 258 2596 346 590 2799 1347 4025 388 2939 4522 2806 M11611 GO_REGULATION_OF_INTERLEUKIN_10_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-10 secretion. 8/20 Gene Ontology BP GO:2001179 0.080000643503278 0.110687777050476 2180 2374.63636363636 2596 0.0083035642128614 200 1.54833184965335 -1.15638005773015 -1 5.04955352445937 2179 2914 4316 1080 1681 2596 3325 3820 200 2751 1259 2807 M15331 GO_FLAVONOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVONOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. 7/29 Gene Ontology BP GO:0009812 0.0138965011573029 0.0266278337001484 1035 2342.18181818182 2596 0.00139841745059117 306 1.60263598799171 1.60263598799171 1 8.61743888774238 1033 3608 4549 2850 3151 2119 306 900 3326 2596 1326 2808 M10477 GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of ERBB signaling pathway. 98/115 Gene Ontology BP GO:1901184 0.038213269480497 0.060029150200119 4070 2513.54545454545 2597 0.00353578404559919 567 1.13077541320147 -1.11535594153235 -1 4.71226431519484 4611 790 2597 574 1350 4271 4066 4070 567 1741 3012 2809 M16808 GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase A. 13/16 Gene Ontology BP GO:0034199 0.0155421484128422 0.0290973218023566 4650 2569.72727272727 2597 0.00142300418785466 1039 1.05841886343521 0.883724316137879 1 5.5481591715 4646 1189 1916 1803 1039 4427 3011 2672 2597 1507 3460 2810 M15282 GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle development. 119/167 Gene Ontology BP GO:0048634 0.120128246156176 0.156570512427083 2720 2301.27272727273 2598 0.0115670464511197 19 1.12952223621857 1.18172049646695 1 3.09918784191638 2720 19 1312 450 3744 3023 2598 3770 2406 2403 2869 2811 M11212 GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. 45/66 Gene Ontology BP GO:0045806 0.0035621800949953 0.00995214887028993 2465 2083.90909090909 2599 0.000324360089875636 285 1.17215765932391 -1.316149960922 -1 8.0127762454837 2465 3378 2886 675 2775 2989 3666 356 849 2599 285 2812 M12351 GO_RESPONSE_TO_TESTOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TESTOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. 45/66 Gene Ontology BP GO:0033574 0.0573623008465274 0.0837748856995895 3645 2404.72727272727 2599 0.00535590304425904 186 1.49929751923918 -1.41794397303116 -1 5.50947651225944 3644 186 1124 338 2599 4547 4473 3581 383 1293 4284 2813 M13650 GO_MESODERM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_MORPHOGENESIS.html The process in which the anatomical structures of the mesoderm are generated and organized. 77/111 Gene Ontology BP GO:0048332 0.0312180091673352 0.050736079865739 2095 2427.27272727273 2599 0.00287909072461728 986 1.29118460324091 1.31480264630671 1 5.70470569625451 2093 2599 986 1935 3960 2889 3036 4006 1245 1251 2700 2814 M16703 GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 10/13 Gene Ontology BP GO:0007260 0.0389538087790035 0.0609865653595907 755 2247.18181818182 2599 0.00360555752733925 559 1.14667349096767 1.26692169550301 1 4.75172503790019 751 2906 2599 2686 3122 1929 559 2570 3899 3024 674 2815 M12048 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION.html The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. 26/30 Gene Ontology BP GO:0000715 0.0150360099183112 0.0283249207084623 1460 2540.63636363636 2600 0.00137634258611478 303 0.515322619539738 -0.515322619539738 -1 2.71640073755159 1228 3802 4022 3677 2600 478 303 1459 4424 4498 1456 2816 M12211 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. 20/40 Gene Ontology BP GO:0099623 0.0259285093013821 0.0439349431097345 1750 2781.09090909091 2600 0.00238538488781443 955 1.44461133359848 -1.57322182624529 -1 6.69256637956445 1747 3829 955 3493 4194 4644 2560 1204 3521 1845 2600 2817 M13473 GO_FACE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FACE_DEVELOPMENT.html The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. 76/90 Gene Ontology BP GO:0060324 0.0167051614180982 0.0308082108911656 1730 2425.18181818182 2600 0.00153030663825574 1062 1.16821111829471 1.28422536315285 1 6.02568245690533 1729 2600 1071 2729 1062 4574 3207 2968 3505 1418 1814 2818 M15805 GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-6 production. 110/195 Gene Ontology BP GO:0032675 0.123295302069215 0.160159977813528 1630 2554.90909090909 2604 0.0118910147307122 1508 1.15190089953847 1.25685906247165 1 3.12203314848743 1630 2988 1508 3150 4288 2508 2794 1739 3082 1813 2604 2819 M10756 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. 87/124 Gene Ontology BP GO:0051149 0.0907307126980899 0.123297314890249 1480 2479.27272727273 2605 0.00860945031032452 1167 1.15669624191872 1.26029189545888 1 3.58432806692817 1477 3330 2605 4510 3239 1701 1167 1549 3070 2713 1911 2820 M10943 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html The directed movement of a protein to a specific location on a chromosome. 17/20 Gene Ontology BP GO:0070199 0.176670627387467 0.218455601709775 3070 2642.09090909091 2605 0.0175173866132795 1556 1.88369615790017 -2.29376149470159 -1 4.24400882343307 1556 3193 2553 3070 2519 2605 3230 1936 3298 3067 2036 2821 M12054 GO_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_PRECURSOR_CELL_PROLIFERATION.html The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. 87/155 Gene Ontology BP GO:0061351 0.192140532245046 0.2354569124404 3065 2493.36363636364 2605 0.0192101030645937 703 1.19307102648601 -1.25439464017319 -1 2.55134003893766 3063 2086 2197 1611 3115 3277 2605 1980 703 2714 4076 2822 M11902 GO_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 100/164 Gene Ontology BP GO:0002028 0.018812715827318 0.0338367092170508 2135 2336.72727272727 2607 0.00172504913004221 792 1.0536656918041 1.07341374684532 1 5.28711002944977 2134 792 897 2854 2611 4502 2947 2607 3329 1581 1450 2823 M12807 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. 65/94 Gene Ontology BP GO:1904427 0.139819710159735 0.178315594959717 3555 2795.27272727273 2607 0.0135988050119639 1380 1.11670634891108 -1.23472375636589 -1 2.84826664573042 3555 2607 1418 1380 1898 3541 4501 2510 2778 2197 4363 2824 M13069 GO_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JNK_CASCADE.html An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 86/112 Gene Ontology BP GO:0007254 0.272218828827611 0.321154718695455 2995 2623.09090909091 2607 0.0284735707080327 1495 1.14238018009065 -1.26139205259626 -1 1.91598180204218 2993 1495 2607 2149 3415 2412 2516 2178 2779 2664 3646 2825 M12317 GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. 118/140 Gene Ontology BP GO:0007006 0.338039656304611 0.390200575734398 1800 2939.54545454545 2609 0.0368099279068726 1800 0.753167877338529 -0.731064684742679 -1 1.04178780272753 1800 2987 3967 3402 2384 1855 2609 2315 4069 4351 2596 2826 M16328 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. 43/69 Gene Ontology BP GO:0051155 0.0508799412692654 0.0757097431166907 2610 2831.09090909091 2609 0.00473602021087738 1284 1.33110758027716 1.53510658750904 1 5.0903027237418 2609 3741 2196 3794 3500 3574 2364 1284 2488 2145 3447 2827 M12968 GO_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 108/167 Gene Ontology BP GO:0090279 0.0210141253739875 0.0369255005155452 2645 2581 2610 0.00192887050870943 915 1.06961081232337 -1.07834192972071 -1 5.22854311273226 2645 1456 915 2373 1823 4403 3861 3793 2805 1707 2610 2828 M12616 GO_MICROTUBULE_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_DEPOLYMERIZATION.html The removal of tubulin heterodimers from one or both ends of a microtubule. 12/16 Gene Ontology BP GO:0007019 0.031267144000001 0.050798191701119 2690 2482.63636363636 2611 0.00288368829699575 173 1.24295671662348 -1.65595694695153 -1 5.48896920234627 2686 2881 2611 1981 1287 4653 3858 2967 173 2580 1632 2829 M14853 GO_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. 16/21 Gene Ontology BP GO:0030225 0.011673466990362 0.0232918704571846 2615 2539.18181818182 2611 0.0010668974451928 951 1.19031203776412 1.44656741326334 1 6.63418560087634 2611 1781 2604 1385 951 3504 3328 3881 2024 3002 2860 2830 M10159 GO_NEURONAL_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_DIVISION.html The self-renewing division of a neuronal stem cell. 16/21 Gene Ontology BP GO:0036445 0.165374178459133 0.206462584483592 4090 2861.63636363636 2612 0.0162994993308748 384 1.28855393398965 -1.29767966266905 -1 3.00780235103014 4090 3197 2231 2612 4495 3694 4546 1887 384 2440 1902 2831 M10701 GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that modulates the activity of a monooxygenase. 66/91 Gene Ontology BP GO:0032768 0.158803473663377 0.199436589191819 1865 2471.09090909091 2612 0.0155979774549532 1262 1.05259459570581 1.14919033333457 1 2.50917548062006 1865 2612 1899 3669 3298 2021 1262 2941 3240 1414 2961 2832 M10760 GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 1554/2178 Gene Ontology BP GO:0010647 8.89326290551787e-06 0.000116236944661165 1945 2306.54545454545 2613 8.89329849627464e-07 149 1.15462370515873 1.18680270025913 1 15.5217754783455 1941 1259 4260 705 3171 2823 2475 2887 2613 149 3089 2833 M14683 GO_REPLICATIVE_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATIVE_SENESCENCE.html A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. 19/22 Gene Ontology BP GO:0090399 0.000444668409697694 0.00224651694931962 1035 2174.54545454545 2613 4.04325738553482e-05 18 0.954812062694969 0.838532441551642 1 8.63520725476051 1031 3519 2613 3788 819 462 18 2866 4274 3240 1290 2834 M14924 GO_NEUROBLAST_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_DIVISION.html The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. 16/21 Gene Ontology BP GO:0055057 0.190597503386038 0.233812334103674 4095 2871.72727272727 2613 0.0190399480426037 385 1.28855393398965 -1.29767966266905 -1 2.76979065573058 4091 3198 2232 2613 4496 3695 4547 1978 385 2451 1903 2835 M12515 GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 15/25 Gene Ontology BP GO:0070875 0.0130985718627856 0.0254826539011208 1835 2643.81818181818 2614 0.00119792870179081 727 0.863931364196553 0.999686739809512 1 4.69686959982118 1835 2854 2614 3640 1840 2839 2415 727 4585 3441 2292 2836 M13783 GO_VIRAL_LIFE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LIFE_CYCLE.html A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. 322/480 Gene Ontology BP GO:0019058 0.062476553883657 0.0898323360624349 4110 2651.90909090909 2614 0.00584770000429294 287 0.997719091670408 1.08306779861236 1 3.55933436348586 287 4288 4107 4108 4106 1051 767 1774 2614 4262 1807 2837 M14075 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/23 Gene Ontology BP GO:0051590 0.0244736586321909 0.0418661520645531 3410 2526.54545454545 2615 0.00225002093075187 757 1.25567040649254 -1.07793869975939 -1 5.90577711839378 3408 1173 2615 1603 3372 4513 4176 939 757 2795 2441 2838 M15812 GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE.html Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. 13/23 Gene Ontology BP GO:0051969 0.00109771030069874 0.0042266961698888 1460 2350.81818181818 2615 9.9841672389911e-05 190 1.46185838607696 1.55211150343599 1 11.8546242363727 1456 2372 1351 3731 2803 2999 2879 190 3958 1505 2615 2839 M13390 GO_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINESIS.html Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. 63/100 Gene Ontology BP GO:0032465 0.232983675634346 0.279544363776846 2590 2863.81818181818 2616 0.0238249765228332 1331 0.927899838429532 -1.02200974473641 -1 1.74543947664962 2588 2616 3763 3313 4164 2444 3495 2205 1331 4008 1575 2840 M14073 GO_ACTIN_MEDIATED_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MEDIATED_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. 79/134 Gene Ontology BP GO:0070252 0.0266756410668827 0.04489291783964 885 2402 2617 0.00245497186140989 885 1.14774119220227 1.0063439598384 1 5.27828140285581 885 3683 1273 3959 2847 3167 2617 972 3896 1827 1296 2841 M11938 GO_RESPONSE_TO_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METAL_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. 355/517 Gene Ontology BP GO:0010038 3.1415874845034e-07 6.35556807191057e-06 2265 2420.27272727273 2618 2.85598903010945e-08 175 1.25415617696264 1.25666248042133 1 22.2728603190571 2263 2948 175 3199 2618 3059 2589 4153 2517 229 2873 2842 M12587 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization. 34/39 Gene Ontology BP GO:0031113 0.0043814505902091 0.0114702123219346 2830 2159.27272727273 2618 0.000399109177858667 365 1.02025388747843 -1.1274803804576 -1 6.75792915650747 2828 3096 3336 2434 959 2833 4093 403 787 2618 365 2843 M11540 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. 19/23 Gene Ontology BP GO:2000696 0.0389516462275281 0.0609865653595907 3190 2583.72727272727 2619 0.00360535370097439 1357 1.10442423397725 -1.26899523436839 -1 4.57625456042056 3189 2309 2016 3258 1357 3283 2481 2078 3102 2729 2619 2844 M10390 GO_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 49/68 Gene Ontology BP GO:0010043 0.0274779827943031 0.0460905025024846 3390 2527 2620 0.00252975512141989 965 1.47207862429273 1.56429893012648 1 6.71532655628261 3387 2150 965 2296 2768 3874 4376 2620 1070 986 3305 2845 M13735 GO_POSITIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPAIR.html Any process that activates or increases the frequency, rate or extent of DNA repair. 46/61 Gene Ontology BP GO:0045739 0.110573229573237 0.145543772900785 4015 2657.09090909091 2620 0.0105960171948226 1581 0.943662698888844 -0.94739418246349 -1 2.68979863449739 4011 1581 3076 1886 2204 2573 2620 1671 2671 3313 3622 2846 M15708 GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. 18/27 Gene Ontology BP GO:0039531 0.213955830728776 0.258379569265765 3015 2539.72727272727 2620 0.0216479095121334 146 1.45098720142706 -1.53909696995601 -1 2.90503567029328 3015 1745 2839 1294 3294 4358 4439 2047 146 2140 2620 2847 M10594 GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 281/347 Gene Ontology BP GO:0033673 0.024788325708479 0.0423421730989549 4505 2875.54545454545 2621 0.00227928299977915 415 1.06970235918232 -1.06282415941075 -1 5.01157953387669 4501 2490 2326 2621 1276 4279 4324 4632 3024 1743 415 2848 M13203 GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE.html Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 35/43 Gene Ontology BP GO:0072595 0.00428021961512258 0.0112901711276448 1620 2602 2621 0.000389869978901659 687 0.73853734508006 -0.745971319940292 -1 4.90630801139317 1617 3760 3552 3650 687 1282 2621 1670 4465 3933 1385 2849 M13280 GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 586/759 Gene Ontology BP GO:0010563 0.104567952561361 0.138777719129496 2590 2675 2621 0.0109841233589966 977 1.08662882710739 1.1138177185948 1 3.17572814832505 2590 2450 4417 3229 2621 1978 2761 3176 2979 977 2247 2850 M16475 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. 62/90 Gene Ontology BP GO:1902305 0.0860014817852342 0.117834185732242 2160 2631.36363636364 2621 0.00814179536936881 1224 1.0516049959396 1.0423702780075 1 3.32847183252245 2160 2621 1224 3303 3315 2922 2100 2919 3496 2328 2557 2851 M12508 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that activates or increases the frequency, rate or extent of response to oxidative stress. 13/22 Gene Ontology BP GO:1902884 0.000225352957337789 0.00138151160802731 2625 2569.63636363636 2622 2.04887312967957e-05 199 0.769230909345595 -0.596046369413038 -1 7.51009045034518 2622 2358 2836 1895 199 3343 881 4279 4284 3282 2287 2852 M12293 GO_ANDROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 10/34 Gene Ontology BP GO:0006702 0.000778516630742402 0.0033386524265847 3805 2510.63636363636 2623 7.07992965378401e-05 357 2.36069730506914 -2.36069730506914 -1 19.9768413557166 3803 3589 1416 3235 357 3509 2623 860 3489 2315 2421 2853 M12534 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/43 Gene Ontology BP GO:0043267 0.0556141889953652 0.0817091321109676 3040 2767 2624 0.00518835721329428 1114 1.14936622877052 1.11075692474956 1 4.26370336880429 3039 2746 1114 2386 4423 2624 2428 1622 3831 2258 3966 2854 M10300 GO_REGULATION_OF_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATURATION.html Any process that modulates the frequency, rate or extent of cell maturation. 22/24 Gene Ontology BP GO:1903429 0.000859305728205641 0.00357314526661381 1440 2276.90909090909 2625 7.81492319183002e-05 160 1.14605505587691 1.14605505587691 1 9.57722353950027 1440 3493 2625 3432 4094 817 1173 160 4085 3417 310 2855 M14035 GO_MITOTIC_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_CHECKPOINT.html A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. 164/191 Gene Ontology BP GO:0007093 0.260243471378094 0.309300861384999 2285 2982.72727272727 2625 0.0270310468324931 1434 1.06258497513536 -1.04811098325813 -1 1.84074292984383 2284 4653 3924 4245 2625 1434 3748 2190 1874 4113 1720 2856 M11558 GO_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SENESCENCE.html A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. 47/66 Gene Ontology BP GO:0090398 0.0432502016744756 0.0663293303860696 3095 2588.36363636364 2626 0.00401132989685274 595 0.997121194951893 -1.16180878603677 -1 4.00626642970098 3093 2161 2626 3320 1828 1384 595 4031 2873 2070 4491 2857 M13649 GO_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REGENERATION.html The regrowth of lost or destroyed tissues. 57/80 Gene Ontology BP GO:0042246 0.236567523100585 0.283405943611489 4010 3074.90909090909 2626 0.024240508123896 1031 1.13738806543131 -0.890299448814805 -1 2.11873810736376 4007 2626 2229 2581 4570 4645 4173 2099 1031 2381 3482 2858 M14885 GO_LATERAL_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. 26/49 Gene Ontology BP GO:0021670 0.266556673114427 0.315755651731525 4015 2715.09090909091 2626 0.0277888523608 1207 0.907150029166527 0.885692808745128 1 1.54209883226098 1207 2748 2486 3545 4015 1937 1601 2424 4015 3262 2626 2859 M11235 GO_CELLULAR_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENTATION.html The deposition or aggregation of coloring matter in a cell. 48/56 Gene Ontology BP GO:0033059 0.404355530824528 0.455892000224504 2960 2767.09090909091 2627 0.046008987961748 1706 0.887302163460402 -0.834392297170746 -1 1.02422703032303 2960 2157 3802 3322 2445 2013 2627 3470 1706 3835 2101 2860 M12732 GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 72/101 Gene Ontology BP GO:0050805 0.0610268236782454 0.088185655458036 2390 2748.36363636364 2627 0.00570804380404377 1374 1.0840562835101 1.09605641337955 1 3.8980419571734 2390 3340 1857 3265 2217 2627 3525 1374 3819 2281 3537 2861 M13852 GO_DICARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSPORT.html The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 68/107 Gene Ontology BP GO:0006835 0.0442463840888989 0.0672695983754418 4630 2432.63636363636 2627 0.00410565077485834 109 1.21782260432676 -1.2721322941846 -1 4.86991446109606 4628 109 1068 942 3547 4333 4416 2627 854 1257 2978 2862 M14111 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein. 31/58 Gene Ontology BP GO:0042517 0.156377721486446 0.196761908619912 2630 2405 2627 0.0153402502986697 296 1.14769709358267 1.26539707652286 1 2.7598533465474 2627 296 1394 2658 3133 3663 2392 3193 3332 1569 2198 2863 M10796 GO_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. 1260/1734 Gene Ontology BP GO:0051336 0.00413159648355706 0.0110329917313101 2235 2399.63636363636 2628 0.000413929818435181 467 1.11268446120009 1.11560714728789 1 7.43534227787431 2231 1269 4263 692 2628 2345 2661 3395 2833 467 3612 2864 M15466 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. 213/264 Gene Ontology BP GO:0031110 0.0948923592718127 0.127974786387107 2625 2964.36363636364 2628 0.00902281176016096 1528 0.99064256320286 -1.14154712831439 -1 3.01346651502273 2621 3969 3877 2628 4272 2545 4059 1578 1645 3886 1528 2865 M15663 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. 54/90 Gene Ontology BP GO:1901379 0.0783015612691583 0.108660055050818 2630 2634.27272727273 2629 0.0073850664705155 1205 1.13640309542902 -1.20512377031329 -1 3.73449710140877 2629 1556 1205 2013 3464 3701 2894 4430 2314 1870 2901 2866 M15855 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. 68/82 Gene Ontology BP GO:0032233 0.139877911369647 0.178315594959717 2120 2538.45454545455 2629 0.0136048726098019 1036 1.11084880675633 1.05914324593428 1 2.83327049263174 2711 2120 2119 1155 3857 3538 3618 3017 2629 1036 2123 2867 M10768 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 58/104 Gene Ontology BP GO:0035725 5.41199026838513e-07 1.02783635586922e-05 3205 2470.72727272727 2630 4.91999236339345e-08 186 1.67066946999026 -1.84313670745662 -1 28.4808833863639 3203 2630 186 1712 4460 4492 3524 1119 1428 521 3903 2868 M12129 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition. 26/30 Gene Ontology BP GO:1902751 0.676721591100915 0.691390059851284 2595 3096.09090909091 2631 0.0975647236203937 2246 0.795230760958707 0.803357468417521 1 0.425106368653153 2594 2246 3785 2445 4492 2631 2500 3328 2577 3926 3533 2869 M14613 GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. 8/13 Gene Ontology BP GO:0048484 0.00165644252074828 0.00575471437967524 3715 2437.90909090909 2631 0.000165767852843766 251 1.67604772905948 -0.941093174080177 -1 12.8251155807899 3712 1858 4503 817 2631 2734 3921 251 1608 2020 2762 2870 M16443 GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. 42/48 Gene Ontology BP GO:0035924 0.0275798651554663 0.0462447252498683 1360 2563.09090909091 2631 0.00253925520671714 983 0.855838506503513 1.06182263991761 1 3.89545445708005 1357 3061 2631 3844 4364 1231 1636 983 4049 3412 1626 2871 M14575 GO_PEROXISOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOMAL_TRANSPORT.html Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 21/21 Gene Ontology BP GO:0043574 0.0339884797993887 0.0544400676442532 2635 2624.09090909091 2632 0.003138656737708 816 0.587256417257565 -0.608415840717113 -1 2.52735825586055 2632 2790 3852 2683 2063 816 2405 1096 4334 4582 1612 2872 M10787 GO_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_PROLIFERATION.html The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. 18/25 Gene Ontology BP GO:0043616 0.0995318019435421 0.133229459926599 2635 2858.63636363636 2633 0.00948567272663121 1012 2.38893028627201 -2.875005913804 -1 7.13927570807625 2633 4535 1375 4545 4157 1332 2592 2116 4009 3139 1012 2873 M13434 GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. 22/26 Gene Ontology BP GO:0001836 0.00400249081754451 0.0108134606122247 3970 2639.54545454545 2633 0.000364526473301377 389 1.14689708138388 -0.604118636081097 -1 7.69851707013846 3968 2787 2450 3747 2633 2354 4211 389 434 3797 2265 2874 M14770 GO_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 58/98 Gene Ontology BP GO:0014902 0.0107209916837999 0.0217932609457059 4305 2513.54545454545 2633 0.000979417838967036 236 1.1787672630104 -1.28775134729198 -1 6.68613675109022 4303 2633 947 3220 2994 2319 3936 1328 4258 1475 236 2875 M14130 GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of anion transmembrane transport. 32/44 Gene Ontology BP GO:1903959 0.0112961503334397 0.0227241623439235 1720 2272.45454545455 2634 0.00103223382718484 522 1.1049470372381 1.31923769958175 1 6.19812466080997 1716 3102 2791 2634 3188 3162 1957 679 2001 3245 522 2876 M14214 GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. 53/71 Gene Ontology BP GO:0043124 0.42298962354292 0.474349780487158 2380 2245.09090909091 2635 0.0487614980616248 160 0.98584772318319 1.04149886598946 1 1.08106649892014 2380 160 3246 417 2810 1827 2635 4378 722 2725 3396 2877 M13335 GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. 86/122 Gene Ontology BP GO:0031032 0.0337520508935179 0.0541545837267375 2425 2654.54545454545 2636 0.00311647926636372 1092 1.21018120337054 1.25827527078186 1 5.22897960341387 2425 4004 1675 3574 2374 2988 2636 1092 2934 1920 3578 2878 M10186 GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 70/102 Gene Ontology BP GO:0070373 0.456125900794567 0.505563081561963 3170 2759.72727272727 2637 0.053862190870057 1609 1.078666741427 1.09845055858656 1 1.0817855724957 3168 2115 2637 1916 3218 4065 2045 4132 2117 1609 3335 2879 M10213 GO_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 53/102 Gene Ontology BP GO:0051339 0.00981181586841341 0.0203088875603771 4255 2600.72727272727 2637 0.000895986449304038 790 1.32620903679645 -1.47996252382927 -1 7.66269264293865 4251 2637 790 1760 2524 3715 3619 3139 3297 1795 1081 2880 M11608 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. 35/45 Gene Ontology BP GO:0060043 0.101716111830766 0.135806332381221 4160 2949.18181818182 2637 0.0097043447802281 1265 1.23885546913183 1.44385004213576 1 3.66192532305661 4158 2198 1265 2229 4398 3652 3935 2637 2538 2288 3143 2881 M16164 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. 31/60 Gene Ontology BP GO:0002717 0.0377522560077544 0.0594594909641031 990 2713.63636363636 2637 0.00349237209957815 987 0.876771212574004 -0.936106862874931 -1 3.66377429602917 987 4451 3150 4368 1347 1582 2637 1796 4382 4062 1088 2882 M16688 GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. 113/187 Gene Ontology BP GO:0034111 0.000571713859864419 0.00267968427588706 3855 2386.81818181818 2637 5.19874986531027e-05 304 1.25682154881954 -1.27546935121648 -1 11.0408792568517 3853 1452 642 530 2637 3917 4310 4188 1550 304 2872 2883 M12817 GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. 213/342 Gene Ontology BP GO:0050714 0.0186763905119202 0.0336399838420737 2620 2550.27272727273 2638 0.00171244088436904 896 1.20356064405571 1.24634598021502 1 6.05119390620829 2618 3291 896 3507 2750 2465 2638 1645 3095 965 4183 2884 M15297 GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 418/577 Gene Ontology BP GO:0051090 0.36044312048158 0.413089123054382 1465 2564.27272727273 2638 0.0398200074305414 1464 1.038440034164 1.11336895407294 1 1.35252468450154 1464 3283 2346 2937 3380 1753 1828 3003 3493 2082 2638 2885 M15378 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. 37/41 Gene Ontology BP GO:0071526 0.0298886169012877 0.0490552855173515 1415 2572.09090909091 2638 0.0027547791711251 974 1.33968478132064 1.37090647096393 1 5.98640447481872 1412 3081 974 2298 3474 4382 3138 2638 3121 1690 2085 2886 M11122 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 24/27 Gene Ontology BP GO:0010875 0.00209692347512995 0.00671610900661189 2695 2419.09090909091 2639 0.000190811347512781 525 1.33833750829862 -1.34749590130596 -1 9.93180662950048 2692 1687 1801 2639 525 2217 3651 2731 3816 2684 2167 2887 M14086 GO_DETECTION_OF_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_BIOTIC_STIMULUS.html The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. 38/76 Gene Ontology BP GO:0009595 0.0139396511772157 0.0266808708052591 1495 2697.09090909091 2639 0.00127534247230445 747 1.10024541909685 1.30969792183437 1 5.90947112738255 1492 3758 2106 3989 4249 1934 2299 747 3591 2864 2639 2888 M10643 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. 18/31 Gene Ontology BP GO:2001014 0.0120266684426317 0.0238128035164107 4410 2739.54545454545 2640 0.00109935653248151 873 1.14292806010994 -1.34084175520027 -1 6.33213013161523 4406 3510 1950 2308 960 4111 2882 873 4105 2640 2390 2889 M14161 GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 164/262 Gene Ontology BP GO:0071241 0.00534856524647018 0.0132236312921497 2410 2927.18181818182 2641 0.000487419357065881 699 1.24122750101984 1.13128894073765 1 7.96174522201792 2410 4649 699 4336 2588 2641 2057 4459 3125 2207 3028 2890 M14293 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. 30/60 Gene Ontology BP GO:0032753 0.0263470938577545 0.0445145343936572 1150 2524.54545454545 2641 0.00242436538123108 1150 1.17169924984708 -1.03940197124276 -1 5.40340928934145 1150 4116 2641 3600 1214 2084 2938 1584 3613 2721 2109 2891 M12070 GO_POSITIVE_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASODILATION.html Any process that activates or increases the frequency, rate or extent of vasodilation. 27/43 Gene Ontology BP GO:0045909 0.0164225554058941 0.0304196458215068 4220 2730.63636363636 2642 0.00150422210260071 876 1.87348345294209 -2.09530764412702 -1 9.70525268004018 4220 3798 876 3568 4506 1230 2642 4177 2341 1614 1065 2892 M15794 GO_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. 51/61 Gene Ontology BP GO:0030850 0.0178883817556918 0.0325389524273784 3845 2447.09090909091 2642 0.00163959193330605 688 1.3281980222548 1.20875397846934 1 6.74457090506823 3845 2642 892 1378 2904 3415 3147 3700 2067 688 2240 2893 M16655 GO_RESPONSE_TO_IRON_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IRON_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. 34/50 Gene Ontology BP GO:0010039 0.0138150532218727 0.0265078113985047 1700 2830.81818181818 2642 0.00126387056670913 746 1.23355316137112 1.30138360410815 1 6.63868440986257 1700 4100 2642 4225 3775 2260 2619 746 3229 3348 2495 2894 M13623 GO_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that modulates the frequency, rate or extent of reproductive process. 121/184 Gene Ontology BP GO:2000241 0.0221552737279581 0.0385036022134923 1705 2917.45454545455 2643 0.00203468976528437 926 1.26690140181605 1.35119489085733 1 6.11619459005333 1701 3993 926 4428 3874 3102 2519 2528 3884 2494 2643 2895 M14541 GO_POSITIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WOUND_HEALING.html Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 52/85 Gene Ontology BP GO:0090303 0.000318494676178557 0.00178334022654492 4250 2502.81818181818 2643 2.89582540089178e-05 420 1.57266758854476 -1.75057267943162 -1 14.769087367749 4248 2643 420 1268 1257 2265 4556 3477 3802 731 2864 2896 M16254 GO_AXIS_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_ELONGATION.html The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. 35/43 Gene Ontology BP GO:0003401 0.000136804602710031 0.000958662374111104 3800 2183.36363636364 2643 1.2437555499623e-05 230 1.44093056247447 -1.33763542765591 -1 14.8590579708774 3798 230 570 424 2643 3988 4478 4467 255 241 2923 2897 M13142 GO_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_IMPORT.html The directed movement of the hexose monosaccharide glucose into a cell or organelle. 14/18 Gene Ontology BP GO:0046323 0.107752074008387 0.142515747686476 3935 2611.63636363636 2644 0.0103111303024703 508 1.13364143562008 0.928019206434358 1 3.26884672914318 3931 3215 2517 1786 1777 3820 3046 3265 508 2219 2644 2898 M15630 GO_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 1700/2497 Gene Ontology BP GO:0051049 2.31546132521691e-05 0.000249973121722373 2240 2530.90909090909 2645 2.31548545169589e-06 171 1.15478261056706 1.17158134110334 1 14.2109622936321 2237 1874 4566 1439 3039 2845 2645 3073 2307 171 3644 2899 M13385 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of activation. 272/554 Gene Ontology BP GO:0050867 0.000462137813807295 0.00231217983617779 2400 2435.72727272727 2648 4.20213563869763e-05 443 1.18209501408061 1.19088091130643 1 10.6426983686941 2399 1948 443 1504 3779 3234 2687 2648 3787 583 3781 2900 M12200 GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 63/100 Gene Ontology BP GO:0009118 0.0125320530092479 0.0245648198859995 3335 2614.18181818182 2649 0.00114581954483141 972 1.02995655981296 -0.970996585040918 -1 5.65763434394308 3331 3028 2649 2188 972 4185 2110 2977 1023 2396 3897 2901 M13029 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 18/19 Gene Ontology BP GO:2001241 0.01667642604243 0.0307674109339519 1275 2403.72727272727 2649 0.00152765405176859 796 1.07207393049041 1.17538752430352 1 5.53103479888144 1275 3849 2898 3375 3768 1232 1466 796 3315 2649 1818 2902 M15607 GO_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of ATP metabolic process. 63/100 Gene Ontology BP GO:1903578 0.0125320530092479 0.0245648198859995 3335 2591 2650 0.00114581954483141 973 1.02995655981296 -0.970996585040918 -1 5.65763434394308 3332 3029 2650 2189 973 4186 2111 2712 1024 2397 3898 2903 M11852 GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. 10/16 Gene Ontology BP GO:0048712 0.0327309524365457 0.0527710054356365 2140 2839.45454545455 2651 0.003020754956501 1074 1.50350300813224 0.990372000946122 1 6.5567331358116 2138 4588 2190 4519 3865 2847 2465 1074 1880 3017 2651 2904 M16611 GO_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. 25/43 Gene Ontology BP GO:0030224 0.250290116898738 0.29838583498074 1285 2545.09090909091 2651 0.0258481540571435 1283 1.49425209630262 1.3917743162833 1 2.6725742542382 1283 3140 1567 2895 2175 3153 2450 2939 2651 2345 3398 2905 M10347 GO_METENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. 120/189 Gene Ontology BP GO:0022037 0.093063211402944 0.125878814726133 3840 2662.45454545455 2652 0.0088409166838024 768 1.14730540382293 -1.11920494393833 -1 3.5198421424872 3840 768 1587 1591 1716 4275 4327 3194 2652 2229 3108 2906 M14341 GO_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_APOPTOTIC_PROCESS.html Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 46/69 Gene Ontology BP GO:0051402 0.0143190412086008 0.0272835785190908 3125 2533.27272727273 2652 0.00131028155285397 1015 1.01373576284584 1.2175976406755 1 5.41036127645448 3125 2652 2833 1412 1015 3272 2440 1542 2402 2963 4210 2907 M15441 GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 67/82 Gene Ontology BP GO:0051785 0.526607379234294 0.576135465689436 2655 2691.45454545455 2652 0.0657251021586608 1529 1.31270059910043 -1.30954091498095 -1 1.06411581001032 3353 1529 1948 2217 4611 2654 3135 2652 2284 2571 2652 2908 M11800 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 1274/1619 Gene Ontology BP GO:0051130 0.0806519121458292 0.111456295579015 2255 2630.18181818182 2654 0.0083737888952828 901 1.12675569866683 1.17361077861465 1 3.6601937717782 2251 1271 4324 1830 3552 3492 2827 2654 2397 901 3433 2909 M14334 GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 23/32 Gene Ontology BP GO:0071236 0.17601268424025 0.21769989892873 1145 2843.45454545455 2654 0.0174460373906033 1142 0.913104792338179 0.884636329177894 1 2.05644934908187 1142 3809 2654 3360 2407 1982 1326 4396 4381 3482 2339 2910 M15581 GO_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 18/25 Gene Ontology BP GO:0000305 5.56655381853905e-08 1.49717774090533e-06 3250 2455.18181818182 2655 5.0605035994426e-09 1 1.35851263584843 1.57262414856165 1 27.0433473338085 3249 1754 1649 1328 1 4098 3535 1842 3314 2655 3582 2911 M10894 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. 45/59 Gene Ontology BP GO:2000378 0.010268050912493 0.0211000020689681 4540 2693.90909090909 2656 0.000937844586126771 910 1.18246751840432 -1.05160761044376 -1 6.76391830438006 4537 910 2413 2656 914 3324 4407 3288 1190 1929 4065 2912 M10061 GO_L_PHENYLALANINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. 6/12 Gene Ontology BP GO:0006558 0.00859962274309517 0.0183466504464107 3280 2740.72727272727 2658 0.000863308421298669 174 1.20377220208232 1.20377220208232 1 7.13590167550777 3276 2427 4222 2624 2247 4138 4467 614 174 3301 2658 2913 M13556 GO_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSPORT.html The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 298/504 Gene Ontology BP GO:0015711 1.23107534470607e-09 5.02753116501237e-08 3955 2147.36363636364 2658 1.1191594049045e-10 58 1.23576521538846 -1.30921656518302 -1 30.8262319348651 3954 642 83 245 2658 3905 3857 2979 1318 58 3922 2914 M10298 GO_REGULATION_OF_RNA_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_STABILITY.html Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. 160/186 Gene Ontology BP GO:0043487 0.38692732294601 0.438794256316788 2535 2766.90909090909 2659 0.0435045563483859 731 0.781356988011083 -0.723524208890279 -1 0.945007996280127 2532 731 4094 2428 3813 1743 2587 2659 2753 4289 2807 2915 M13543 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 6/12 Gene Ontology BP GO:1902222 0.00585209098043456 0.0135741671644875 3280 2751.72727272727 2659 0.000586755947853427 175 1.20377220208232 1.20377220208232 1 7.67440599322632 3277 2428 4433 2625 2248 4139 4468 512 175 3305 2659 2916 M15904 GO_PATTERN_SPECIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_SPECIFICATION_PROCESS.html Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. 382/609 Gene Ontology BP GO:0007389 1.23482453585879e-06 2.037460484167e-05 2495 2390.54545454545 2660 1.12256838995131e-07 213 1.19976160240446 1.21698853208932 1 19.2310865049247 2491 2473 213 1473 2929 4092 2919 3296 2660 753 2997 2917 M16112 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 6/12 Gene Ontology BP GO:1902221 0.00482801936348073 0.0122825446136008 3280 2762.09090909091 2660 0.000483854094701961 176 1.20377220208232 1.20377220208232 1 7.85312674517427 3278 2429 4594 2626 2249 4140 4469 454 176 3308 2660 2918 M16388 GO_L_PHENYLALANINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. 6/12 Gene Ontology BP GO:0006559 0.0108385069681331 0.0219649707851582 3280 2787.63636363636 2661 0.00108917356706759 177 1.20377220208232 1.20377220208232 1 6.81416676188254 3279 2430 4620 2627 2250 4141 4470 700 177 3309 2661 2919 M13489 GO_LIPID_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSLOCATION.html The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. 24/30 Gene Ontology BP GO:0034204 0.494622865998166 0.5446001409109 3335 2826.81818181818 2662 0.0601555902372044 1049 0.998518202416878 1.14850048526659 1 0.890336471280285 3333 1049 2389 2049 2982 3690 2662 2604 4423 2259 3655 2920 M14570 GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 29/48 Gene Ontology BP GO:0006509 0.00012148210850861 0.000875009676301182 2730 2420 2662 1.10444379240751e-05 149 1.25868548355396 -1.30983850591669 -1 13.1490162611349 4025 2729 3110 2662 149 2515 3069 2728 2658 2637 338 2921 M10110 GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS.html The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 1008/1359 Gene Ontology BP GO:0048646 1.26735043353993e-07 2.89067723885357e-06 2180 2574.36363636364 2664 1.2673505058179e-08 79 1.22893889597259 1.23287290572599 1 23.2624301618156 2176 1283 4224 2239 2770 3819 2806 2664 2598 79 3660 2922 M12585 GO_CEREBELLAR_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 62/95 Gene Ontology BP GO:0021695 0.18566070871413 0.228358254730861 4380 2758.36363636364 2665 0.0184975250234122 1326 1.20643598779843 -1.12843068497619 -1 2.63487729834474 4377 1537 1608 1326 3382 3803 4336 1963 2665 2602 2743 2923 M13165 GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. 86/157 Gene Ontology BP GO:0055007 0.0395133757954824 0.0617039872824893 1500 2352.54545454545 2665 0.00365831225964658 950 1.15172399132882 1.30200989642211 1 4.75270117334808 1498 2594 1439 3309 3088 3372 2697 1155 3111 2665 950 2924 M13169 GO_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium. 52/89 Gene Ontology BP GO:0003341 0.11219509481983 0.147553356754287 4310 2763.90909090909 2667 0.0107601690437322 1293 1.26173565157374 -1.28326520958323 -1 3.57433114576352 4310 1565 1293 1757 3872 2667 4143 2743 2113 2389 3551 2925 M16197 GO_HISTONE_H3_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_ACETYLATION.html The modification of histone H3 by the addition of an acetyl group. 46/51 Gene Ontology BP GO:0043966 0.000468985778659661 0.00232364264403131 1155 2435 2667 4.2644162246968e-05 287 0.875379119481906 0.661402469979315 1 7.87206359559577 1151 2667 3758 2935 287 1806 1079 2808 3739 3993 2562 2926 M12270 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. 97/124 Gene Ontology BP GO:0090317 0.0285689734389325 0.0474959513292895 2670 2744.63636363636 2668 0.00263153229918728 1247 1.03675552588581 1.24426239864543 1 4.68007697248724 2668 2079 3467 3609 1247 4301 3810 1441 1603 3903 2063 2927 M10062 GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 35/50 Gene Ontology BP GO:0050856 0.458427507195545 0.507630459538522 2430 2584.72727272727 2669 0.0542268870733233 1062 0.935874949232316 0.90430712770579 1 0.931498495077441 2429 1610 2815 1062 2526 3471 2860 3405 1326 2669 4259 2928 M10811 GO_THYMIC_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMIC_T_CELL_SELECTION.html The process of T cell selection that occurs in the thymus. 16/27 Gene Ontology BP GO:0045061 0.0925247007965303 0.125332585969798 4585 2810.45454545455 2669 0.00878742937617233 1400 1.23497617751801 -1.35891944040956 -1 3.79759838121537 4584 3876 2081 2174 2590 3094 3461 1562 3424 1400 2669 2929 M13646 GO_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 461/645 Gene Ontology BP GO:0009314 0.434930579607613 0.485074781139555 2670 2809.72727272727 2669 0.0505681415646348 2038 1.12935448261882 -1.06571147918312 -1 1.20249384047689 2669 3279 2186 3587 2495 2038 2396 3578 2824 3187 2668 2930 M10358 GO_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. 25/56 Gene Ontology BP GO:0097028 0.201676312771373 0.245205091017821 3640 2262 2671 0.0202682480973525 333 1.21166393840546 1.18157985549302 1 2.51828173672668 3638 333 1470 538 3618 4296 2939 2671 458 1432 3489 2931 M11482 GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. 68/77 Gene Ontology BP GO:0072384 0.0112616143279204 0.0226742931492053 2835 2386.54545454545 2671 0.00102906164753779 244 1.01157803990743 -1.13278920059932 -1 5.67677653574291 2834 4025 3753 2643 1305 2671 2713 981 1293 3790 244 2932 M16618 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM.html Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. 42/56 Gene Ontology BP GO:0010880 0.0321633385350115 0.0519278328256101 1060 2551.72727272727 2671 0.00296758291313603 494 0.811187594759809 0.921584496266664 1 3.55205624931009 1056 2671 2508 4177 2758 2177 1641 2896 4027 3664 494 2933 M12301 GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 41/74 Gene Ontology BP GO:0070286 0.0642149180693022 0.0919643009468954 3940 2832.90909090909 2673 0.00601542012864257 1180 1.31061045456342 -1.39177959456734 -1 4.63326413772308 3939 2673 1180 2774 1864 4005 4129 1396 2552 2011 4639 2934 M12174 GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of striated muscle contraction. 91/141 Gene Ontology BP GO:0006942 0.00310072464993687 0.00897412442079353 2080 2688.72727272727 2674 0.000282282137905296 623 1.17842174167682 -1.19324048458561 -1 8.23665421264652 3649 2080 623 2353 3814 2077 4412 2674 3299 713 3882 2935 M16947 GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. 108/199 Gene Ontology BP GO:0002700 0.00352446307534362 0.0098850673234321 1650 2671.90909090909 2675 0.000320920187501512 355 1.07357833272866 1.12008570154308 1 7.34878022378669 1648 3668 2459 4208 3979 2675 2134 355 3604 1708 2953 2936 M10109 GO_ATP_DEPENDENT_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. 77/200 Gene Ontology BP GO:0043044 0.0770408253745485 0.107230320211718 1580 2710.72727272727 2676 0.00726171239125693 735 0.909691879777185 -0.935154957918609 -1 3.00523246847372 1579 4008 3828 4175 2676 735 1649 2485 2869 3641 2173 2937 M10656 GO_SECRETION_BY_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION_BY_CELL.html The controlled release of a substance by a cell. 480/746 Gene Ontology BP GO:0032940 5.43064514354911e-05 0.000480638435210021 2945 2440 2676 4.93707200209388e-06 318 1.15197089832396 1.10414335015529 1 13.05808764364 2943 2464 318 1997 1436 3310 2676 3504 3228 553 4411 2938 M11393 GO_NEURAL_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. 193/237 Gene Ontology BP GO:0021915 0.444424722149826 0.494478295591377 2680 2788.09090909091 2676 0.0520295272756635 1121 1.12607112380912 1.14352033514623 1 1.16686366064773 2676 1985 2180 1121 2510 3440 4086 4477 1643 2739 3812 2939 M10842 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. 52/89 Gene Ontology BP GO:0002720 0.0262348834188587 0.0443732870039802 2585 2905.54545454545 2677 0.00241391434158717 962 1.09271515666563 1.20325466731643 1 5.04360386898862 2583 4049 2484 4072 2036 3287 2200 962 3924 2677 3687 2940 M15396 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. 27/46 Gene Ontology BP GO:0032736 0.0235846889489785 0.0405691525617734 270 2511.54545454545 2678 0.00216739865220831 267 1.03940197124276 -1.03940197124276 -1 4.93533659502922 267 4466 3192 3629 1181 1377 2678 1389 3989 3660 1799 2941 M13832 GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM.html A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. 232/471 Gene Ontology BP GO:0022412 0.342260517478536 0.394681087441792 2645 2642.72727272727 2681 0.0373698794273813 1271 1.05111639070378 1.06238261627256 1 1.44031157335441 2641 2956 2564 2317 2812 2950 2722 2323 1271 2681 3833 2942 M15518 GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 51/58 Gene Ontology BP GO:0061001 0.0145709947174901 0.0276663745425387 3150 2598.54545454545 2682 0.00133349140654485 886 1.15048032829459 1.27661089315914 1 6.11781167396838 3147 2136 1655 886 1019 3204 3642 4329 2682 1662 4222 2943 M14697 GO_CELLULAR_COMPONENT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MORPHOGENESIS.html The process in which cellular structures, including whole cells or cell parts, are generated and organized. 977/1351 Gene Ontology BP GO:0032989 6.6380613065568e-06 9.03125709339438e-05 2250 2470 2684 6.63808113537622e-07 140 1.21341329021098 1.28986033727889 1 16.7673048528923 2247 1287 4512 1173 3683 3744 2782 2684 1598 140 3320 2944 M16946 GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 33/50 Gene Ontology BP GO:0010907 0.119213646760965 0.155465554478355 2145 2592 2685 0.01147368642728 1692 1.01472363180579 0.992201285168861 1 2.79379005390902 2145 2709 2832 1692 2328 2685 2173 1720 4135 3300 2793 2945 M11731 GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 65/100 Gene Ontology BP GO:0032370 0.0515985810787203 0.0766320452471386 2800 2698.81818181818 2686 0.00480455092170969 1467 1.25155812848308 1.27668470274505 1 4.76295779231414 2800 2611 1595 3520 1467 2686 1886 3111 4184 2195 3632 2946 M13092 GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION.html Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. 37/62 Gene Ontology BP GO:0002026 0.00280007449192403 0.00830939453536508 4390 2491.09090909091 2687 0.000254876789193184 615 1.2187952732372 -1.37859682020858 -1 8.65848522338919 4387 2687 615 1848 2739 4191 3714 1234 3154 1688 1145 2947 M13402 GO_AMINOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 151/196 Gene Ontology BP GO:0006022 1.30895997250882e-07 2.95659745246773e-06 3650 2663.54545454545 2687 1.18996368217233e-08 155 1.28940974967506 -1.18019774078555 -1 24.364430117952 3650 1422 155 1438 2687 3140 4599 4604 2664 392 4548 2948 M16365 GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 39/62 Gene Ontology BP GO:0021680 0.317391437281894 0.369667674010677 2490 2915.45454545455 2688 0.0341165984584224 1734 1.00498750462757 1.02484135629973 1 1.4743367751237 2490 2688 2234 2433 4624 2009 1734 3160 4338 3267 3093 2949 M11270 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. 41/62 Gene Ontology BP GO:0086004 0.03114753546233 0.0506569320189519 2690 2623.18181818182 2689 0.00287249683267775 932 1.19724015054578 -1.27531307036192 -1 5.29164031640712 2689 932 984 1850 2540 4594 3634 3720 3118 1624 3170 2950 M13777 GO_LONG_TERM_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_MEMORY.html The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. 32/45 Gene Ontology BP GO:0007616 0.434548553416754 0.484764905070285 2555 2977.27272727273 2689 0.0505098065885124 1930 1.37830823052587 1.34629059839118 1 1.47122863596366 2553 3775 2007 4509 2942 1930 1996 4062 3796 2491 2689 2951 M14041 GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. 24/47 Gene Ontology BP GO:1903020 0.040938454518751 0.0633477315848848 4300 2651.63636363636 2689 0.00379279180203853 484 1.09325653926404 -1.06742005560267 -1 4.46821079941393 4298 1685 2606 875 1381 4445 3800 3695 484 2689 3210 2952 M15375 GO_PROTEIN_K63_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. 25/32 Gene Ontology BP GO:0070536 0.00137424669002145 0.00499950730935871 2420 2625.36363636364 2693 0.000125009625010085 448 0.853117944989606 1.06828452611353 1 6.70102668386452 2416 3123 3376 2600 448 3207 2693 1436 4368 3567 1645 2953 M10147 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT.html The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. 9/15 Gene Ontology BP GO:0010248 0.000379314169905244 0.00200025261221394 2695 2822 2694 3.79378931121293e-05 95 1.71530411440549 -1.71530411440549 -1 15.8172183219547 2694 3599 4228 4503 4590 2211 2602 95 1088 3549 1883 2954 M11642 GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/27 Gene Ontology BP GO:0034035 0.00159535116305862 0.00559816663779169 3755 2578.09090909091 2694 0.000145137202105597 471 1.40343887228235 1.69645382553761 1 10.7948521933992 3754 1823 2433 2980 471 4592 4249 605 1106 2694 3652 2955 M16322 GO_REGULATION_OF_MYOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of myoblast proliferation. 10/25 Gene Ontology BP GO:2000291 0.0301959101421105 0.0494375685753836 2990 2404.63636363636 2694 0.00278350041366429 402 1.49858079608938 -1.49858079608938 -1 6.68042565907218 2990 2402 2694 1546 3944 2541 3061 3368 402 3023 480 2956 M11523 GO_POSITIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of STAT cascade. 62/133 Gene Ontology BP GO:1904894 0.0470234325324494 0.0708319946822555 2685 2266.90909090909 2696 0.00436906083576855 137 1.11178528059494 1.19638971932046 1 4.35977068873391 2682 137 1405 2696 2948 3603 2897 1238 2784 1430 3116 2957 M15324 GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 151/255 Gene Ontology BP GO:0043901 0.199393073913332 0.243000516741418 1930 2753 2696 0.0200138447050606 1540 1.17767836293286 1.3334747308074 1 2.46314095075278 1927 3986 2183 4147 2071 3237 2696 2053 3076 1540 3367 2958 M11081 GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY.html The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. 21/35 Gene Ontology BP GO:0007250 0.011731082529482 0.0233467609108981 460 2251.09090909091 2697 0.00107219157277866 202 1.30122282893111 1.30122282893111 1 7.24879081277686 458 4528 2945 4603 3718 202 345 1137 2697 3737 392 2959 M15878 GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. 62/133 Gene Ontology BP GO:0046427 0.0467870361392059 0.0705469976529212 2685 2267.63636363636 2697 0.00434661088676229 138 1.11178528059494 1.19638971932046 1 4.36642623463987 2683 138 1406 2697 2949 3604 2898 1236 2785 1431 3117 2960 M10386 GO_COGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COGNITION.html The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. 274/419 Gene Ontology BP GO:0050890 0.000825922933903468 0.00346530154323971 2700 2472.72727272727 2698 7.51121058687842e-05 486 1.28752020280418 1.21438154815117 1 10.8193082422949 2698 2491 486 1273 3283 2812 2886 4473 1779 764 4255 2961 M13260 GO_APPENDAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APPENDAGE_DEVELOPMENT.html The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. 209/288 Gene Ontology BP GO:0048736 0.00241783863767932 0.00741120104158225 2025 2547.63636363636 2698 0.000220045452774031 599 1.18443221129758 1.21741668167667 1 8.61524769858371 2021 2517 599 2698 1401 4414 2791 3951 3103 1700 2829 2962 M16565 GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of establishment of protein localization. 600/851 Gene Ontology BP GO:1904951 0.523419999946072 0.573592383360591 2520 3030.90909090909 2698 0.0714322817566062 2303 1.0742658528088 1.10311405562979 1 0.87595288825311 2519 2939 4636 3148 3786 2531 2303 2698 2620 2634 3526 2963 M14599 GO_LIMB_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMB_DEVELOPMENT.html The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. 209/288 Gene Ontology BP GO:0060173 0.00241783863767932 0.00741120104158225 2025 2533.81818181818 2699 0.000220045452774031 600 1.18443221129758 1.21741668167667 1 8.61524769858371 2022 2518 600 2699 1402 4415 2792 3789 3104 1701 2830 2964 M15720 GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 11/17 Gene Ontology BP GO:0002283 0.0193956236897849 0.0347107065494498 4435 2530.45454545455 2699 0.00177897818318418 848 1.4338025754186 -1.97442376891319 -1 7.14412488583852 4435 2900 2699 2196 2573 3255 1304 848 1409 3102 3114 2965 M15915 GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. 44/101 Gene Ontology BP GO:0002715 0.239842424950761 0.287033642823017 1660 2973.90909090909 2699 0.0246217723550344 1607 0.921891583776752 -0.911747053768499 -1 1.69787822055235 1656 4391 2478 4341 2493 1897 2997 2699 4436 3718 1607 2966 M10583 GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 4/13 Gene Ontology BP GO:0010455 0.00525070999993344 0.0130510436056038 3440 2373.72727272727 2700 0.000526315789473684 130 1.39439148784205 -1.38901089229541 -1 8.97271804634554 3438 1871 4248 130 3048 2700 477 2985 944 1989 4281 2967 M10081 GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION.html The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. 40/66 Gene Ontology BP GO:0060395 0.00452325371446785 0.0116991103576537 2960 2432.72727272727 2701 0.000412052772011318 574 1.43793570739387 -1.45965298309399 -1 9.48673551753625 2957 1600 674 767 3860 3247 2701 4612 1321 574 4447 2968 M15952 GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT.html The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. 18/23 Gene Ontology BP GO:0060841 0.0761340254386285 0.106158711527102 4065 2922.63636363636 2701 0.00717308311480823 1474 1.4433811256336 1.3587603597386 1 4.79609435168318 2981 4196 2305 4065 2701 2694 3317 1474 4064 2142 2210 2969 M16930 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 49/86 Gene Ontology BP GO:0045980 0.0583695547661818 0.0849526238120251 4540 2863.18181818182 2701 0.00545257048404416 902 1.28813960540555 -1.22272181837935 -1 4.70532995483496 4538 902 1126 2274 3837 4332 3790 3692 2430 1873 2701 2970 M14166 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. 13/21 Gene Ontology BP GO:0032717 4.79921080185471e-05 0.000438717639705893 3655 2371 2702 4.36301408899091e-06 93 1.01754132595448 -0.792867790902162 -1 11.670907532048 3654 3229 2483 3041 93 1201 487 3949 1375 2702 3867 2971 M10844 GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 277/312 Gene Ontology BP GO:0034976 0.00355770753331972 0.00994832521186096 2600 2718.72727272727 2703 0.000323952172999266 637 0.884526732986489 -0.905338883394802 -1 6.04444239514013 2598 3631 4049 2703 637 1628 2785 2588 3219 4140 1928 2972 M13934 GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 175/244 Gene Ontology BP GO:0046824 0.0910306697923655 0.123488544181888 830 2317.54545454545 2704 0.00863918639852785 830 1.04274895208249 1.09196107601616 1 3.2277824705077 830 3641 3120 4101 2704 1509 1084 1557 2761 3218 968 2973 M14815 GO_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_FUSION.html The joining of two or more lipid bilayer membranes that surround a cell. 17/32 Gene Ontology BP GO:0045026 0.267706519980779 0.316714578558496 2865 2482.72727272727 2704 0.0279275123098238 463 1.18353480685286 -1.17880787007616 -1 2.00985563235508 2863 463 1934 2002 3523 1459 2545 3997 2704 3075 2745 2974 M11271 GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 90/224 Gene Ontology BP GO:0038094 0.00577426225782821 0.0134540021460564 3185 2751.72727272727 2705 0.000526315789473684 220 0.977580791133877 0.894828066559116 1 6.24327184087483 3181 801 2705 220 3975 4409 2640 4310 1529 2112 4387 2975 M14751 GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. 13/19 Gene Ontology BP GO:0071071 0.00112772627099084 0.0043046024109273 255 2129 2705 0.000102573160171362 45 1.00155281427604 1.00155281427604 1 8.09135711088277 255 3235 2828 3516 4256 234 45 1105 4357 2705 883 2976 M10151 GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION.html The acetylation of the N-terminal amino acid of proteins. 13/15 Gene Ontology BP GO:0006474 0.00733328758667803 0.0162021781295408 2920 2564.27272727273 2706 0.000668895128179448 824 0.523425798455369 0.529162142359234 1 3.19342250789981 2917 2354 3766 1919 824 2975 2495 2904 902 4445 2706 2977 M11713 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 137/200 Gene Ontology BP GO:0034764 5.05942065589504e-06 7.00639414044036e-05 2850 2438.54545454545 2706 4.59948390115243e-07 246 1.25886118578251 -1.24358262708758 -1 17.8702462086924 2850 1434 246 2488 1707 4443 4279 2913 2706 701 3057 2978 M11488 GO_MICROTUBULE_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_NUCLEATION.html The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). 21/24 Gene Ontology BP GO:0007020 0.139489792884631 0.178015909569992 2710 2607.45454545455 2707 0.0135644174986152 135 0.987019736986457 -0.982544078385011 -1 2.51871536053041 2707 4507 3764 2936 4189 1898 1785 2161 135 3375 1225 2979 M16444 GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that activates or increases the frequency, rate or extent of gluconeogenesis. 13/18 Gene Ontology BP GO:0045722 0.000980396434451087 0.0039156949437776 2930 2194.09090909091 2708 8.91666914486154e-05 18 1.28217907148348 0.979725527434442 1 10.5417477952075 2930 2868 2981 1099 397 2617 2948 2956 18 2708 2613 2980 M14957 GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM.html The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. 43/51 Gene Ontology BP GO:0001738 0.0592081138324583 0.0859043821834825 4295 2699.27272727273 2709 0.00553311979755178 890 1.18608505157192 -1.3651067862351 -1 4.31207824138515 4292 2173 1856 2333 1515 2915 4061 4128 2709 2820 890 2981 M15037 GO_ORGANELLE_INHERITANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INHERITANCE.html The partitioning of organelles between daughter cells at cell division. 16/16 Gene Ontology BP GO:0048308 0.018565417362987 0.0335153739112753 2710 2791.27272727273 2709 0.0017021785464037 1097 0.66374217999594 0.65917645570505 1 3.33600029032348 2709 2332 3767 3122 1097 3517 4484 1940 1256 4592 1888 2982 M15178 GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. 33/54 Gene Ontology BP GO:0032727 0.0176498603755627 0.0321805643916509 1600 2713.54545454545 2709 0.00161755185206378 818 0.996436285514454 1.05864680624438 1 5.0736123166457 1598 4113 2825 4258 2392 2709 1044 818 4101 3585 2406 2983 M10927 GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. 96/145 Gene Ontology BP GO:0048704 0.000241569685567557 0.0014503532218656 1110 2349 2710 2.19632922782652e-05 407 1.29092501080732 1.37764448091419 1 12.5174698687371 1106 3000 407 2710 3141 2360 1829 3035 3719 1225 3307 2984 M13222 GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. 12/14 Gene Ontology BP GO:0050812 0.00202696061456542 0.00657243744917971 4550 2555 2710 0.00018443914168511 105 1.16119538565502 -0.436814011003817 -1 8.65310707272811 4550 3566 3348 3101 518 2710 1561 2443 105 3757 2446 2985 M12800 GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. 32/41 Gene Ontology BP GO:2000272 0.0428380104555144 0.0658056330965693 2545 2589.54545454545 2711 0.00397232878064692 1397 0.930614515361846 -0.717077545566058 -1 3.74929571753269 2541 2210 2767 1586 1397 3306 2711 3718 2435 2858 2956 2986 M14102 GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 58/103 Gene Ontology BP GO:0045912 0.359003369385116 0.411641862431973 2615 2773 2711 0.0396237056570919 162 1.02117764005088 0.998998716475912 1 1.33518549603806 2613 162 1910 2367 3969 4294 3444 2352 2982 2711 3699 2987 M15850 GO_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEATH.html The process of cell death in a neuron. 58/89 Gene Ontology BP GO:0070997 0.0339004040111216 0.0543364036733547 3325 2643.63636363636 2711 0.00313039448821337 1094 1.01619166430429 -0.777070667420107 -1 4.38401835566897 2373 2629 2711 3325 1909 3171 2270 1094 3318 2959 3321 2988 M11047 GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. 168/342 Gene Ontology BP GO:0050851 0.00224012779154847 0.00704754199734619 3545 2267.09090909091 2714 0.000203855639635908 370 0.977262507124202 -0.850127641887602 -1 7.17949335201547 3542 716 2792 370 538 2157 3728 3052 2714 2867 2462 2989 M12790 GO_PROSTAGLANDIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. 28/44 Gene Ontology BP GO:0006693 0.0389022720680567 0.0609581636385365 3950 2782.72727272727 2714 0.00360070016543608 1034 1.25948343101223 -1.09130621436304 -1 5.22112071179731 3946 2714 1034 1494 3648 3758 1986 2045 4053 1713 4219 2990 M10915 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. 324/441 Gene Ontology BP GO:0090316 0.464914340560293 0.514201670222734 2235 2811.36363636364 2715 0.0552623786794712 2065 0.956929245787678 1.03749445214977 1 0.93441917190476 2232 2951 3595 2715 3452 2212 2065 2765 2685 3942 2311 2991 M15959 GO_PROSTANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. 28/44 Gene Ontology BP GO:0006692 0.0389022720680567 0.0609581636385365 3950 2747.54545454545 2715 0.00360070016543608 1035 1.25948343101223 -1.09130621436304 -1 5.22112071179731 3947 2715 1035 1495 3649 3759 1987 1643 4054 1719 4220 2992 M15489 GO_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 60/79 Gene Ontology BP GO:0046677 0.0291471489103674 0.0481953389765243 1250 2695.81818181818 2716 0.00268551171278079 1246 0.999445888335837 0.970976245627823 1 4.48957871695629 1246 4358 2716 3153 1254 1734 1840 3633 3993 3946 1781 2993 M10596 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. 28/29 Gene Ontology BP GO:1902108 0.335404634383199 0.387447309777811 2600 2856.45454545455 2719 0.0364620017776854 1610 0.752208203531962 -0.714471642184661 -1 1.04835560949516 2600 2719 3279 3234 2688 1610 3252 2412 3309 3986 2332 2994 M12288 GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING.html Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. 9/11 Gene Ontology BP GO:0006346 0.0571502369264595 0.0835438430470676 2450 2793.45454545455 2719 0.00586755099827913 1287 0.81253713036157 0.81253713036157 1 2.98428231178577 2448 3938 4360 3829 3159 1287 1337 1384 2719 4506 1761 2995 M15998 GO_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BINDING.html Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 390/486 Gene Ontology BP GO:0051098 0.0943210767245333 0.127321140121629 1065 2378.27272727273 2720 0.00896596612395203 985 1.09249895015784 1.22211301990803 1 3.33270964472418 1061 3626 3109 4267 2838 1764 1419 1592 2720 2780 985 2996 M12976 GO_REGULATION_OF_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METAL_ION_TRANSPORT.html Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 307/505 Gene Ontology BP GO:0010959 1.01636543605815e-07 2.43770534741164e-06 2725 2440.81818181818 2721 9.23968620920586e-09 146 1.14688256945794 -1.2019849422612 -1 21.9987201279335 2721 1366 146 1238 3677 3959 3340 4428 2197 351 3426 2997 M15986 GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. 10/14 Gene Ontology BP GO:0003417 0.0159508603349039 0.0297195721562134 4050 2873.09090909091 2721 0.00146069981916653 1051 1.04066621134936 1.21823840249997 1 5.4222259289735 4050 1852 1946 1124 1051 2721 4269 4005 4062 2325 4199 2998 M12118 GO_LEFT_RIGHT_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_PATTERN_FORMATION.html The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 25/39 Gene Ontology BP GO:0060972 0.000232460158065688 0.00141575538675346 3165 2374.72727272727 2722 2.11349749365583e-05 202 0.932582304216848 1.02373705640778 1 9.07326837107665 3165 357 2537 2178 202 3666 3281 2722 2199 2763 3052 2999 M13963 GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. 24/29 Gene Ontology BP GO:0045683 0.351386770086019 0.404003617793488 4610 3164.54545454545 2722 0.0385918480734574 1806 1.5311441048115 1.00121990434745 1 2.04987154008853 4606 4481 2084 4381 4218 3402 1806 2356 2066 2688 2722 3000 M15337 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. 30/42 Gene Ontology BP GO:0032743 0.587636404497173 0.634843786887705 3335 2546.36363636364 2722 0.077374436833811 613 1.03850951997 1.01980461889182 1 0.689990117720792 3334 979 2479 613 2722 3026 3128 4538 827 2305 4059 3001 M12042 GO_NEGATIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COAGULATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. 48/67 Gene Ontology BP GO:0050819 3.35485543550488e-10 1.60929302488703e-08 2725 2290.54545454545 2723 3.04986857819679e-11 70 1.98913025874929 1.36155362710941 1 52.9899207062836 2723 3054 70 3461 249 3298 1991 2370 3556 109 4315 3002 M13129 GO_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction. 23/38 Gene Ontology BP GO:0019098 6.99095466599725e-05 0.000574715760793025 4590 2570 2723 6.35561529810299e-06 118 1.11178521875765 1.18144428858198 1 12.3070940020725 4590 388 2685 1355 118 3427 4329 2723 2622 3058 2975 3003 M13374 GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. 38/57 Gene Ontology BP GO:2000179 0.130484929072824 0.167859102840987 2640 2674.54545454545 2723 0.0126304318938625 1302 1.10522045264914 1.23070804659935 1 2.91803067178835 2637 2197 2856 3427 1859 3417 2723 3306 1302 2513 3183 3004 M14354 GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed. 104/137 Gene Ontology BP GO:0006733 0.000901125716032833 0.0036812449136969 2105 2412.45454545455 2723 8.19540937514773e-05 386 1.01337650470763 -1.02666180419897 -1 8.42238900924244 2105 2573 3591 3221 386 905 1926 3180 2806 3121 2723 3005 M11834 GO_ERBB2_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB2_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. 53/61 Gene Ontology BP GO:0038128 0.0496579317192733 0.0741760373321922 1535 2345.72727272727 2724 0.00461959554008462 662 1.04223384505275 1.08571190998791 1 4.01497508754212 1533 3039 2897 2706 2976 842 662 3814 1747 2724 2863 3006 M12116 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that modulates the activity of the enzyme nitric-oxide synthase. 57/73 Gene Ontology BP GO:0050999 0.516713099594859 0.566776532865365 3185 2829.45454545455 2725 0.0639665567545865 1729 1.0653544210396 1.17291449689473 1 0.887507612562613 3183 2632 2011 2725 2616 3039 2325 3867 2924 1729 4073 3007 M13320 GO_RENAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_WATER_HOMEOSTASIS.html Renal process involved in the maintenance of an internal steady state of water in the body. 31/53 Gene Ontology BP GO:0003091 0.0914465405492325 0.124016541292795 3840 2842.18181818182 2725 0.00868042828763439 974 0.992621968231405 -1.11494716615362 -1 3.06581568980612 3839 1652 2725 2082 2541 3017 4453 4567 3013 2401 974 3008 M12649 GO_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASOCONSTRICTION.html A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure. 22/39 Gene Ontology BP GO:0042310 0.00169027179715928 0.00582199348953458 3065 2605.72727272727 2727 0.000153779258238403 551 1.89748165777656 1.85017170312456 1 14.4881885438135 3062 3813 551 3701 2968 4137 2601 1745 2727 831 2527 3009 M11349 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. 32/41 Gene Ontology BP GO:0030835 0.00577426225782821 0.0134540021460564 4495 2366.63636363636 2728 0.000526315789473684 112 1.16316132875628 -1.16055163524679 -1 7.43049703154056 4492 259 2170 112 2728 4016 3866 3269 301 554 4266 3010 M13580 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. 122/186 Gene Ontology BP GO:2000379 2.86735489867082e-05 0.000295172618219366 3445 2285.54545454545 2728 2.60672024620545e-06 292 1.24546651899269 -1.1115350962509 -1 15.0204046157508 3445 765 292 1636 1764 3897 3488 2856 2728 311 3959 3011 M16492 GO_ISOPRENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 105/195 Gene Ontology BP GO:0006720 4.69366531418431e-05 0.000429913872183063 3660 2384.45454545455 2728 4.26705950525899e-06 310 1.4261794202568 -1.41825687351895 -1 16.405078328234 3660 3317 310 2969 591 1876 3648 4049 2479 602 2728 3012 M11339 GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/33 Gene Ontology BP GO:0032373 0.00596809451508473 0.0137750229880439 2755 2595.45454545455 2731 0.000544031485480727 777 1.33833750829862 -1.34749590130596 -1 8.50430274923381 2752 2731 1809 3588 777 1907 3333 2564 4219 2977 1893 3013 M13518 GO_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_GROWTH.html The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. 77/100 Gene Ontology BP GO:0035265 2.12779250190443e-06 3.35614186825806e-05 2975 2127.27272727273 2731 1.9343586907838e-07 223 1.3868456896292 1.38714548900276 1 21.2038000492983 2974 822 223 1278 3079 2752 2731 2759 2721 326 3735 3014 M16659 GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 38/47 Gene Ontology BP GO:0072528 0.280222895081759 0.330095476155804 1605 3048.18181818182 2731 0.029449801909646 1604 0.762935068510366 -0.735716723229126 -1 1.2449345800258 1604 4409 3873 4338 4420 1861 2372 2196 1714 4012 2731 3015 M16781 GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 313/463 Gene Ontology BP GO:0060249 0.00444712430890767 0.0115794456683533 2475 2882.09090909091 2731 0.000405103576210723 669 1.30521528912391 1.28805705930038 1 8.63005777710114 2474 4633 669 4408 2731 4341 3106 1364 3800 1546 2631 3016 M10178 GO_ETHER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHER_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. 10/13 Gene Ontology BP GO:0018904 0.152450215088111 0.192340252387467 3850 2540.09090909091 2732 0.0149243922846493 689 1.10178688561583 -1.13782054468497 -1 2.68621008601433 3850 1230 2936 2299 1935 2826 2732 2668 689 3012 3764 3017 M15839 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/33 Gene Ontology BP GO:0032376 0.00596809451508473 0.0137750229880439 2755 2591.81818181818 2732 0.000544031485480727 778 1.33833750829862 -1.34749590130596 -1 8.50430274923381 2753 2732 1810 3589 778 1908 3334 2513 4220 2979 1894 3018 M14633 GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 19/21 Gene Ontology BP GO:0010649 0.0803402352854279 0.111058560541621 3415 2687.63636363636 2733 0.00758486122785627 1647 0.994731210890018 -0.845090274542133 -1 3.23535146478553 3415 1733 1871 3091 1647 3448 2356 1902 3858 2733 3510 3019 M13827 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. 11/17 Gene Ontology BP GO:0001956 0.312243460436082 0.364675908988225 3170 2722.09090909091 2734 0.0334566459598884 710 1.21164710201416 -0.945322623384373 -1 1.80416248073193 3169 1222 2734 1618 3570 4534 4610 2258 710 3100 2418 3020 M12568 GO_NOSE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOSE_DEVELOPMENT.html The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). 18/29 Gene Ontology BP GO:0043584 0.199290646284611 0.242939318093345 3770 2978.72727272727 2735 0.0200024474628878 2002 1.19750710381761 -1.69896450950439 -1 2.50524060307402 3769 3194 2735 2660 2647 2785 4405 2002 2096 2645 3828 3021 M14193 GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of cytoplasmic transport. 585/775 Gene Ontology BP GO:1903649 0.558400384267307 0.607064716821444 2455 2758.63636363636 2735 0.0784840243198564 1163 0.990102208528912 1.03449378048383 1 0.723110085845676 2452 1321 4479 1163 2735 3058 2688 3320 2002 4066 3061 3022 M14608 GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. 55/84 Gene Ontology BP GO:0007157 1.77175441851481e-05 0.000203053529786931 3300 2471.54545454545 2735 1.61069880670401e-06 272 1.59927522338581 -1.55284576368255 -1 20.1787240421675 3297 2142 272 2968 2598 3482 3419 2735 3537 1584 1153 3023 M12254 GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 22/26 Gene Ontology BP GO:0050860 0.00143019306281841 0.00514943863209775 2910 2260.36363636364 2736 0.000130102150989617 456 1.03105185797588 -1.05221676632036 -1 8.05564005889934 2907 1689 2778 582 456 3552 4105 3192 807 2060 2736 3024 M14995 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. 42/54 Gene Ontology BP GO:0030837 0.165515276961746 0.206472542547722 4175 2592.36363636364 2736 0.0163146187174226 1083 1.14651545460423 -1.06477351917159 -1 2.67499207510692 4173 1590 2704 1083 2736 3093 3975 4073 1156 1105 2828 3025 M16608 GO_POSITIVE_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELINATION.html Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 13/16 Gene Ontology BP GO:0031643 0.0019540622154448 0.00641104466609068 2130 2662.63636363636 2736 0.000177799999503538 512 1.54105725244178 1.38957187262467 1 11.5441768785229 2198 3574 1479 4121 512 2127 2128 2736 4311 3294 2809 3026 M13825 GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 35/39 Gene Ontology BP GO:0009262 0.140995556968103 0.179445384729918 665 2562.63636363636 2737 0.0137214619626348 661 0.857759206242622 -0.862768895994379 -1 2.17728048300948 661 3417 3630 3483 4251 1194 1172 2621 1357 3666 2737 3027 M16971 GO_BRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). 33/55 Gene Ontology BP GO:0048854 0.101218072364245 0.135218975225619 4250 2924.27272727273 2737 0.00965444335916029 1619 1.49753930217857 -1.36236945766048 -1 4.43843156253722 4247 4087 1685 2184 1934 3413 4313 1619 2737 1747 4201 3028 M14453 GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. 21/25 Gene Ontology BP GO:0045605 0.135595039370076 0.173712477474935 4330 2921 2738 0.0131593679387345 1148 1.64317922843868 1.00121990434745 1 4.2599235391326 4329 4495 1930 4017 3470 2643 1148 2738 1470 2430 3461 3029 M15792 GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that activates or increases the activity of a monooxygenase. 27/35 Gene Ontology BP GO:0032770 0.107858999033569 0.142616630435692 1615 2408.27272727273 2739 0.0103219129019338 1071 0.973421046984403 1.09642956433158 1 2.80432265770001 1615 2739 2771 3180 3724 2806 1071 1655 2087 2079 2764 3030 M16527 GO_RESPONSE_TO_REDOX_STATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REDOX_STATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. 36/54 Gene Ontology BP GO:0051775 0.00126092564807477 0.00470119153885569 1970 2599.36363636364 2739 0.000114695356867755 204 0.937993867428369 1.11673731193306 1 7.45445389433052 1966 3408 2739 3374 2354 3223 2441 204 3838 3712 1334 3031 M15229 GO_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. 991/1348 Gene Ontology BP GO:0030030 0.00148922678018689 0.00529768517447216 2740 2606 2740 0.000149022573088416 370 1.1615132537078 -1.12997069086935 -1 9.02733870321362 2740 1284 4542 686 3268 4174 3075 2603 1584 370 4340 3032 M12780 GO_REGULATION_OF_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ORGANIZATION.html Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. 25/33 Gene Ontology BP GO:0090224 0.0203310862793073 0.0360204120083669 3475 2507.45454545455 2744 0.00186558558616362 349 0.706490312957848 -0.761961540497428 -1 3.47592639056265 3474 349 3655 1673 2390 1746 383 2744 2800 3888 4480 3033 M13141 GO_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 12/19 Gene Ontology BP GO:0070528 0.0285009196658461 0.0474471481950562 1170 2418.63636363636 2745 0.00262518060824947 458 0.740841327210141 -0.736721693021384 -1 3.34236137592035 1167 3582 2805 4145 2745 919 1171 1237 4620 3756 458 3034 M14727 GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. 104/151 Gene Ontology BP GO:1904064 0.00786077949857032 0.0170837024786771 3225 2789.45454545455 2747 0.000717182546756136 756 1.13458567163231 -1.19161023310328 -1 6.84530847690644 3224 1466 756 2515 1197 4285 4215 4419 2747 1773 4087 3035 M16632 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 59/106 Gene Ontology BP GO:0042346 0.0161633006206526 0.0300350789887766 1410 2827.36363636364 2747 0.00148029887674447 785 1.01958840337091 1.07497670857105 1 5.29620018441944 1410 4033 2633 4029 3524 3070 2532 785 3655 2747 2683 3036 M11202 GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/16 Gene Ontology BP GO:0032375 0.0296586049069577 0.048798263306957 475 2430.36363636364 2749 0.00300620386292149 471 0.885550338921244 0.885550338921244 1 3.96038980044825 471 3263 4285 3990 4073 2045 679 1208 3472 2749 499 3037 M13834 GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. 12/19 Gene Ontology BP GO:0060707 0.00525669488561014 0.0130589435679359 4275 2851.27272727273 2749 0.000479027040530888 745 1.33943410289783 -1.29707721406973 -1 8.61745105594666 4272 3241 1620 2537 745 3723 4414 2749 2543 1371 4149 3038 M11179 GO_BONE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 26/29 Gene Ontology BP GO:0098751 0.00055986007287886 0.00263666894646289 2760 2382.81818181818 2750 5.0909327080664e-05 18 1.1029617590231 -1.23326283753263 -1 9.71445461453841 2756 2750 2571 2930 2237 3365 2726 665 3355 2838 18 3039 M12370 GO_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_SIGNAL_TRANSDUCTION.html The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. 1551/2025 Gene Ontology BP GO:0035556 0.0243789789999461 0.0417195252985469 2475 2559 2750 0.00246506334229118 258 1.05431194056702 1.08074369162292 1 4.96251312671867 2475 567 4365 258 4111 3280 2750 3186 2145 671 4341 3040 M12929 GO_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BINDING.html Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 126/163 Gene Ontology BP GO:0051101 0.171737797566787 0.212921921683523 1625 2946.09090909091 2752 0.0169837140515643 1313 1.23955151974801 1.43210106819672 1 2.83631338930758 1621 4313 2659 4565 4039 2223 1313 3413 2655 2854 2752 3041 M13365 GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. 33/65 Gene Ontology BP GO:0046637 0.277485885546503 0.327036936536951 1810 2892.45454545455 2753 0.0291148718625801 1718 1.40960693368774 -1.50275725070324 -1 2.32867579365914 1809 4429 2753 4374 2507 2468 3089 2204 3169 3297 1718 3042 M12205 GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE.html Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. 32/38 Gene Ontology BP GO:1902668 0.00379853335290004 0.010384592062893 3015 2603.81818181818 2754 0.000345918892842276 646 1.55661671176188 1.67255672839495 1 10.5460940732076 3013 2703 646 1995 1222 2919 4624 4421 2754 993 3352 3043 M15259 GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/16 Gene Ontology BP GO:0032372 0.0296586049069577 0.048798263306957 475 2451.81818181818 2754 0.00300620386292149 472 0.885550338921244 0.885550338921244 1 3.96038980044825 472 3264 4545 3991 4074 2046 680 1171 3473 2754 500 3044 M10120 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. 115/144 Gene Ontology BP GO:0031333 0.664748159638195 0.691390059851284 3380 2308.18181818182 2758 0.0945761616179639 680 1.09856735344642 -0.988620392506428 -1 0.591328202605746 3377 770 2962 868 3360 2400 2758 3047 680 1796 3372 3045 M12548 GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 9/13 Gene Ontology BP GO:0043650 0.0659638681788592 0.0939773051550005 2570 2830 2758 0.00680078492435317 833 0.850004153397232 -1.01067465320201 -1 2.97385515974905 2566 2419 4374 2880 3810 1793 833 1642 4502 3553 2758 3046 M12923 GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rac protein signal transduction. 19/20 Gene Ontology BP GO:0035020 0.104323209079879 0.138571479260256 2760 2686.72727272727 2760 0.00996597591568878 1099 1.16483063939611 1.06859655835422 1 3.40761656343305 2760 3845 2939 3407 1766 2149 1099 2715 1471 3231 4172 3047 M16100 GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. 97/119 Gene Ontology BP GO:0032273 0.409451649063047 0.461190637397811 4560 2990.81818181818 2760 0.0467538894824125 1935 1.13282175864023 -1.30988216704634 -1 1.29114764602944 4557 3324 2760 2674 3597 3243 4273 2462 1980 1935 2094 3048 M10304 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. 20/25 Gene Ontology BP GO:1900015 0.0373118173848677 0.0589113967735967 4395 2596.27272727273 2761 0.00345091526897054 765 1.36756533412177 -0.803756077078101 -1 5.73943503547871 4391 1702 1024 765 3740 3008 3168 4530 1634 1836 2761 3049 M11561 GO_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the meiotic cell cycle. 44/61 Gene Ontology BP GO:0051445 0.0207434352672275 0.0365667316827147 4365 2766.18181818182 2761 0.00190378573491873 1144 1.13015133227983 -1.23334279840706 -1 5.54146885189962 4364 1593 2399 3754 1144 2761 4151 2522 1201 2869 3670 3050 M15300 GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a humoral immune response. 8/19 Gene Ontology BP GO:0002922 0.0453770297967789 0.0686631933802966 4220 2424.45454545455 2761 0.00463311506093108 543 1.65257143586946 1.83135828711942 1 6.5619104041692 4217 543 4547 774 3219 3772 3782 2761 580 792 1682 3051 M16368 GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving mucopolysaccharide. 105/130 Gene Ontology BP GO:1903510 0.00015542647800594 0.00104132677153963 4415 2717 2761 1.41306781567255e-05 374 1.25661360400121 -1.12083412215327 -1 12.8026655357185 4414 783 374 1959 2761 3493 4559 4299 2234 717 4294 3052 M15674 GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune effector process. 410/673 Gene Ontology BP GO:0002697 0.0340410418696719 0.0545054947761815 2080 2632.72727272727 2762 0.00314358782815248 1004 1.13994854851438 1.22502367217544 1 4.91396534914021 2080 2945 1004 2762 4573 3227 2326 2016 3720 1523 2784 3053 M12035 GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. 26/36 Gene Ontology BP GO:0060706 0.397303649019785 0.449138454540588 3460 2749.27272727273 2763 0.0449877107595945 1771 1.03870296247549 -0.987483746683422 -1 1.22382915635404 3459 2247 2763 3056 4153 1771 2231 3114 1972 2840 2636 3054 M12079 GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. 23/37 Gene Ontology BP GO:0030320 0.0436696416262318 0.0667525763754456 4240 2508.09090909091 2763 0.00405103256439466 340 1.32268094273884 -1.06275542775077 -1 5.3053003558382 4236 1037 1057 340 2763 3123 4242 4003 700 1675 4413 3055 M14253 GO_REGULATION_OF_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ISOTYPE_SWITCHING.html Any process that modulates the frequency, rate or extent of isotype switching. 18/29 Gene Ontology BP GO:0045191 0.571016013010687 0.619044153899983 2215 2843.09090909091 2763 0.0740542282905698 1773 0.874745746612281 0.842664242644541 1 0.612237410821439 2211 1773 3468 3348 3867 2556 2291 3891 1958 3148 2763 3056 M16731 GO_REGULATION_OF_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING.html Any process that modulates the frequency, rate or extent of protein targeting. 362/501 Gene Ontology BP GO:1903533 0.270782460239481 0.319703320856205 2765 2919.72727272727 2763 0.0282994149952239 1160 0.976041352213246 1.090296917564 1 1.64201288339637 2763 1935 3528 1160 4145 4579 3572 2171 1883 3707 2674 3057 M10053 GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. 15/25 Gene Ontology BP GO:1900225 0.115831770228207 0.151482975668239 1620 2849 2764 0.0111292366219894 1335 0.94157602658026 0.941423081029824 1 2.62790911991786 1618 3555 2764 4211 4622 1797 1335 1698 4242 3430 2067 3058 M10851 GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a sphingolipid. 11/14 Gene Ontology BP GO:0090520 0.0621650521833247 0.0895523182071238 2840 2850.09090909091 2764 0.00581767570096509 1380 1.155344580212 1.32817295687949 1 4.12869908785088 2839 3585 2165 2564 3286 4287 2764 1380 4335 2469 1677 3059 M13241 GO_CELLULAR_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions at the level of a cell. 23/37 Gene Ontology BP GO:0030002 0.0436696416262318 0.0667525763754456 4240 2502.45454545455 2764 0.00405103256439466 341 1.32268094273884 -1.06275542775077 -1 5.3053003558382 4237 1038 1058 341 2764 3124 4243 3928 701 1679 4414 3060 M14754 GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. 278/471 Gene Ontology BP GO:0034110 3.53739956667338e-05 0.000341483821239238 2460 2375.63636363636 2764 3.21586949646912e-06 300 1.25225523772336 1.23535313077164 1 14.8313482321292 2456 2492 300 567 3849 2764 2780 3515 3245 313 3851 3061 M11242 GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html The directed killing of a target cell by a leukocyte. 34/73 Gene Ontology BP GO:0001909 0.68618940391 0.691390059851284 2840 2689.81818181818 2765 0.1 1628 1.03617454079952 0.962030962393966 1 0.557138302671242 2837 1628 2403 2765 2962 2593 2743 3108 3007 2614 2928 3062 M12762 GO_MYELOID_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_ACTIVATION.html A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. 105/180 Gene Ontology BP GO:0002274 0.0306027081503001 0.0499529520465936 1830 2627.90909090909 2765 0.00282153462332053 982 1.17251974627992 1.04190432024928 1 5.2065235774552 1827 2989 982 2777 4463 2765 1739 3527 2690 1008 4140 3063 M15471 GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 11/14 Gene Ontology BP GO:0003376 0.0482143970043841 0.0723449175302804 2840 2841.09090909091 2765 0.00448224068579599 1258 1.155344580212 1.32817295687949 1 4.49474665064989 2840 3586 2166 2565 3287 4288 2765 1258 4336 2483 1678 3064 M13302 GO_ONE_CARBON_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_METABOLIC_PROCESS.html The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. 29/37 Gene Ontology BP GO:0006730 0.0293222335291983 0.0484160229280907 2560 2639.81818181818 2768 0.00270186366580726 734 1.34523716152267 1.44396814957651 1 6.03746035817501 2556 3448 2295 2768 3144 3894 3710 1012 734 2242 3235 3065 M10606 GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 35/39 Gene Ontology BP GO:0061013 0.00441920585867949 0.0115325658218933 3765 2173.45454545455 2769 0.00040255526312372 445 0.918062006123033 0.949695701120261 1 6.07257514738452 537 3763 3672 3763 701 585 445 2769 2802 3931 940 3066 M14103 GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 23/30 Gene Ontology BP GO:0018146 0.00336132699547682 0.00954838492671164 2770 2666.09090909091 2769 0.000306043063482861 632 1.58560191419827 -1.57177989578512 -1 10.9403179959827 4315 2768 632 1960 1446 3989 3806 3730 2769 911 3001 3067 M16029 GO_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group. 57/62 Gene Ontology BP GO:0043967 0.0247812666584724 0.0423421730989549 2015 2599.63636363636 2771 0.00227862645818861 943 0.99883208731319 0.739051299302471 1 4.67884429023924 2014 3718 3932 3426 1196 1410 1136 4182 943 3868 2771 3068 M11436 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 24/31 Gene Ontology BP GO:0010804 0.322589545826547 0.375064756804329 2880 2802.36363636364 2772 0.0347875846737687 1237 1.17704385545717 -1.24194080686494 -1 1.70324058634893 2877 4148 3204 3917 3085 2586 2772 2283 1237 2685 2032 3069 M11445 GO_HIPPO_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPO_SIGNALING.html The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. 37/37 Gene Ontology BP GO:0035329 0.0204011482842995 0.0360937425729452 500 2260.72727272727 2772 0.0018720751229231 385 0.716202169928708 0.624500981632145 1 3.5216924682395 500 3415 3717 3342 2772 639 385 1572 3396 4260 870 3070 M11809 GO_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 31/55 Gene Ontology BP GO:0035456 0.0586528398424273 0.0852582517297139 1885 2770.81818181818 2772 0.00547977464992912 1360 0.948854985634286 -0.952048411174676 -1 3.45811948164246 1885 3779 2941 3986 3153 2241 2310 1360 3654 2772 2398 3071 M15996 GO_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_DUPLICATION.html The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 41/48 Gene Ontology BP GO:0051298 0.114377073112303 0.149956754350956 2775 2851.45454545455 2774 0.0109814415495272 1226 0.70686376338714 -0.619043909919395 -1 1.98080488528481 2774 3072 3963 3657 2760 2600 1542 1690 1226 4287 3795 3072 M14195 GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT.html The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. 6/12 Gene Ontology BP GO:0043369 9.11298073176706e-07 1.58811608033379e-05 4170 2343.27272727273 2776 9.11298446885803e-08 6 1.83671434438105 -2.15490030388184 -1 30.1260196521287 4169 558 4480 158 6 3325 4529 2776 491 1574 3710 3073 M14359 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. 45/59 Gene Ontology BP GO:0060760 0.285821214180345 0.336179501916367 2115 3119.18181818182 2776 0.0301384942382694 2094 1.04450475165079 0.961960636885583 1 1.68000195844193 2112 4396 3238 4476 2251 2776 2094 2571 4289 3520 2588 3074 M15049 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. 65/76 Gene Ontology BP GO:0072332 0.040253588502312 0.0625166713288577 3895 2754.81818181818 2776 0.00372814080802256 578 0.909784052835059 -0.812005787568242 -1 3.73439676505187 3894 1536 3316 1847 2535 4495 3125 2496 2776 3705 578 3075 M14936 GO_POSITIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 431/537 Gene Ontology BP GO:0045862 0.448293696940057 0.497711899752347 4560 2807.09090909091 2777 0.0526315789473684 336 1.04005216987259 -0.882644954441831 -1 1.06684814982229 4558 612 2391 336 3579 2777 4530 4497 1693 2111 3794 3076 M12405 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY.html Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. 22/23 Gene Ontology BP GO:0035794 0.102486985812629 0.136600385272462 2155 2847.90909090909 2778 0.00978163266697472 865 0.708229215051549 -0.622866285258578 -1 2.08275260811843 2151 2778 3495 3347 4602 865 2474 2357 3136 4094 2028 3077 M12863 GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). 13/17 Gene Ontology BP GO:1901070 0.00295446609973602 0.00864055987559502 2210 2510.54545454545 2778 0.000268949203965942 586 0.751771782813471 -0.751771782813471 -1 5.29297797511426 2210 3570 3684 2642 586 2842 3360 1500 634 3810 2778 3078 M14656 GO_ENDOCYTIC_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_RECYCLING.html The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. 29/29 Gene Ontology BP GO:0032456 0.0416717955442374 0.0643113978996141 3725 2806.36363636364 2778 0.00386206535957703 1389 0.943231855416521 1.10327718359783 1 3.83244188360608 1861 4124 3724 4006 1389 2778 1920 2449 1646 3724 3249 3079 M16193 GO_PROTEIN_TETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TETRAMERIZATION.html The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. 124/176 Gene Ontology BP GO:0051262 0.00489509484313175 0.0124057060485251 3960 2570.72727272727 2780 0.000446001880913207 728 1.02899475028202 -1.08295609865025 -1 6.69612730036926 3960 760 3005 803 728 2717 4009 4635 987 3894 2780 3080 M13474 GO_RNA_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DESTABILIZATION.html Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. 21/23 Gene Ontology BP GO:0050779 0.570507998644053 0.618637547818872 1060 2629.54545454545 2782 0.07395459737537 1060 0.884134703311859 0.782006175327493 1 0.619785780793715 1060 2782 3701 2408 3206 2744 2289 3274 1067 3378 3016 3081 M10106 GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 22/37 Gene Ontology BP GO:0010831 0.0261029595649794 0.0441822738653508 3690 2595.18181818182 2783 0.00240162863689238 436 1.27932759250958 -0.853204666995456 -1 5.91495953939272 3686 2783 2386 2826 2008 3592 3295 958 436 2524 4053 3082 M15692 GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 38/54 Gene Ontology BP GO:0006213 0.0399881649835866 0.0621874771619748 390 2585.90909090909 2783 0.00370309624285085 386 0.83698371359566 -0.83698371359566 -1 3.44128088578472 386 4082 3734 4329 4571 665 1019 1162 2783 4011 1703 3083 M15886 GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. 21/26 Gene Ontology BP GO:0042762 0.0676043466752731 0.0962260706882978 4345 2849.72727272727 2785 0.006343253686086 122 1.37586809155446 -0.927679678926835 -1 4.77194911032883 4341 2785 3263 2595 1559 2192 2271 4392 122 3383 4444 3084 M10983 GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. 15/17 Gene Ontology BP GO:1903504 0.140599525988776 0.179039297872406 3385 2511.45454545455 2786 0.0136801334616854 1171 0.724013811628986 0.663265510418577 1 1.83856282483762 3381 2837 3379 2806 1900 1171 2227 1849 1855 3435 2786 3085 M11241 GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that activates or increases the frequency, rate or extent of viral release from host cell. 18/18 Gene Ontology BP GO:1902188 0.0338100585018158 0.0542289116699523 2620 2731.36363636364 2787 0.00312192003123052 1093 0.779496180477133 -0.841705742136041 -1 3.3626833662107 2620 3523 3558 3141 4001 1765 2373 1093 2787 3998 1186 3086 M12830 GO_LYMPHANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHANGIOGENESIS.html Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. 13/15 Gene Ontology BP GO:0001946 0.0221604656625258 0.0385036022134923 3775 2689.54545454545 2787 0.00203517147246579 408 1.09639079138809 1.11374441351778 1 5.29158883835323 2787 4224 2855 3774 2262 1612 408 3773 3656 2698 1536 3087 M13496 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune system process. 1253/2113 Gene Ontology BP GO:0002682 1.70564512513348e-05 0.000196609503195764 2790 2456.45454545455 2787 1.70565821678872e-06 163 1.16445527109603 1.21154743021343 1 14.7452808859046 1722 1270 4430 1710 3966 2787 2357 2788 2973 163 2855 3088 M15165 GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. 15/17 Gene Ontology BP GO:0090266 0.140599525988776 0.179039297872406 3385 2510.72727272727 2787 0.0136801334616854 1172 0.724013811628986 0.663265510418577 1 1.83856282483762 3382 2838 3380 2807 1901 1172 2228 1819 1856 3448 2787 3089 M15944 GO_ARACHIDONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. 37/110 Gene Ontology BP GO:0019369 0.000504927339116683 0.00244223171404358 4260 2371.09090909091 2788 4.59130239514453e-05 449 1.36869247241135 -1.40028130001618 -1 12.2131560842459 4260 946 449 1192 4063 4106 2788 768 3441 612 3457 3090 M14439 GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 22/29 Gene Ontology BP GO:0006144 0.000260101825510259 0.00152424911095622 3620 2387.63636363636 2789 2.36484165405866e-05 190 1.38349223703504 -1.25420040543786 -1 13.3137281449944 3617 1065 2789 1339 214 3892 4628 3016 190 2532 2982 3091 M15788 GO_SNRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_PROCESSING.html Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. 23/23 Gene Ontology BP GO:0016180 0.000732316383922302 0.00319350340617664 2475 2744.09090909091 2789 6.65963876846591e-05 347 0.593490398014531 -0.601647629674293 -1 5.05345936717289 2472 2264 3921 3077 347 1792 2836 2436 3635 4616 2789 3092 M13099 GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 17/22 Gene Ontology BP GO:0009068 0.299225956113429 0.350704880049316 4615 2800.36363636364 2790 0.0318076717784172 454 1.28847507494563 -1.4825334461768 -1 1.99397256738699 4613 1771 2790 1814 3012 3702 4197 2237 454 2037 4177 3093 M11286 GO_PROTEIN_NEDDYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_NEDDYLATION.html Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. 14/16 Gene Ontology BP GO:0045116 0.00614346488827112 0.0140884879867548 3080 2724.27272727273 2791 0.000560062526016776 789 0.604349891296872 -0.559219179757296 -1 3.81422859965775 3078 2343 3661 2791 789 2730 1962 3429 1434 4470 3280 3094 M11705 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 165/207 Gene Ontology BP GO:1903828 0.25415028100881 0.302677567835678 2455 2844.90909090909 2791 0.0263052054901833 1462 1.01923226729454 1.11200984505221 1 1.79796621052756 2455 2014 3611 3522 2183 3838 2962 2477 1462 3979 2791 3095 M15553 GO_GMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GMP, guanosine monophosphate. 21/27 Gene Ontology BP GO:0046037 0.0114610736316536 0.0229962809866686 3200 2334.45454545455 2791 0.0010473836483861 488 1.10563621835956 -1.13678259655525 -1 6.18245509232634 3196 2791 2986 1106 942 3479 4099 766 3394 2432 488 3096 M13707 GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. 33/43 Gene Ontology BP GO:2000300 0.0264743990910183 0.0446485606997131 2260 2417.54545454545 2793 0.00243622364353902 913 1.03325336068921 -1.07977219096499 -1 4.75907990225224 2259 3091 3019 1630 1219 2793 4194 3165 1369 2941 913 3097 M14922 GO_MULTI_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_METABOLIC_PROCESS.html A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism. 160/247 Gene Ontology BP GO:0044033 0.00405296196680879 0.0108945303475224 300 2690.45454545455 2794 0.000369131624772525 299 0.709726253583533 0.699481226642305 1 4.75208361680188 299 4317 4195 4644 669 1104 489 2794 4296 4420 2368 3098 M15403 GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. 16/17 Gene Ontology BP GO:0033235 0.0487077503896118 0.0729207602279388 3590 2707.90909090909 2794 0.00452916280889124 1162 0.875426384202062 -0.93492823958579 -1 3.39286544167374 3588 1162 2794 1873 1451 3871 4157 2560 2965 3006 2360 3099 M12105 GO_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_OLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 432/614 Gene Ontology BP GO:0051259 0.103077068133433 0.137190388451048 4610 2764.54545454545 2796 0.00984083515567562 1271 1.10726293595309 -1.1646375308933 -1 3.25514831078993 4609 1347 1271 1734 1806 3200 4564 3800 2796 2126 3157 3100 M12282 GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 172/233 Gene Ontology BP GO:0010822 0.221613911055364 0.267142364803267 2500 2940.90909090909 2796 0.0225182845233782 1667 0.85917886234317 -0.864683792432119 -1 1.67327311980061 2497 3645 3857 2685 2127 1667 3203 2796 3295 4270 2308 3101 M14081 GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). 14/24 Gene Ontology BP GO:0007191 0.0373001151833661 0.0589113967735967 2590 2807.63636363636 2796 0.00344981401993483 541 1.10518318782701 1.17786830246374 1 4.63621681459981 2586 4213 2574 3961 3592 2916 541 1490 4324 2796 1891 3102 M11334 GO_TISSUE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. 198/311 Gene Ontology BP GO:0001894 7.41400234719258e-08 1.90593110063464e-06 1610 2379.18181818182 2797 6.74000236094958e-09 135 1.47249271605817 1.46440133144773 1 28.7854232544419 1609 3972 135 4334 2797 3745 2838 702 3784 464 1791 3103 M16361 GO_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 433/581 Gene Ontology BP GO:0006979 0.000249795518832511 0.00148394161260319 2990 2374.72727272727 2797 2.2711262361709e-05 408 1.12718583010576 1.09323807297507 1 10.8901001520009 2988 1346 408 2289 1082 3620 3000 3596 2797 667 4329 3104 M16917 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. 34/64 Gene Ontology BP GO:0045620 0.187885699142498 0.230911822004765 2985 2946.90909090909 2797 0.0187416214614919 1138 1.10513581040528 1.08953251681399 1 2.39449301613418 2982 4095 2245 4529 4166 2797 2568 1987 2388 1138 3521 3105 M12328 GO_OVARIAN_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVARIAN_FOLLICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. 54/77 Gene Ontology BP GO:0001541 0.213420334504663 0.257866740184419 2535 2876.18181818182 2798 0.0215873367318993 1281 1.53543338333209 1.33581161296136 1 3.07925629316549 2533 4364 1488 3956 3071 2798 2575 3982 1625 1281 3965 3106 M13911 GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 266/357 Gene Ontology BP GO:0051091 0.504033384198774 0.553912927887788 1575 2945.63636363636 2799 0.0617601851378679 1575 1.05676672855567 1.1018371676268 1 0.916290774487264 1575 3632 2148 3424 4601 2594 2143 3166 3799 2521 2799 3107 M13869 GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 80/131 Gene Ontology BP GO:0042345 0.0348645068009411 0.0556134899365029 1860 2718.72727272727 2801 0.0032208727372836 1111 0.993651692897161 1.07595456363633 1 4.25226503299741 1859 3005 2674 3040 3859 3090 2599 1111 3211 2657 2801 3108 M12680 GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING.html Any process that activates or increases the frequency, rate or extent of telomere capping. 19/20 Gene Ontology BP GO:1904355 0.0716718100877406 0.101118536185038 2950 2409.63636363636 2805 0.00673810157316198 52 1.25431019133519 -0.827739879189004 -1 4.25704141665553 2947 2805 2807 1637 4637 707 1257 4426 52 3228 2003 3109 M15296 GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 29/51 Gene Ontology BP GO:0035249 0.173769430025118 0.215268678888944 2805 2847.36363636364 2805 0.017203161244551 1424 1.63742628977305 1.88526465570034 1 3.72349347029183 2801 3114 1424 2538 3587 3089 2805 4170 2600 3053 2140 3110 M13653 GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. 25/31 Gene Ontology BP GO:0045879 0.522594911813322 0.572823115351563 3220 2852.63636363636 2806 0.065007961098905 1864 1.03324176190784 -0.905433797491002 -1 0.844153732077914 3220 2744 1864 2293 3288 2014 3002 3961 3423 2764 2806 3111 M16392 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 6/14 Gene Ontology BP GO:0045086 0.00282261723264524 0.00835473154166559 3375 2557.45454545455 2806 0.000282620888056453 441 1.51403889239758 -1.76627240586792 -1 10.7462859926492 3375 2921 4621 1599 598 4250 3436 2806 441 2424 1661 3112 M13800 GO_MAINTENANCE_OF_CELL_NUMBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_NUMBER.html Any process by which the numbers of cells of a particular type in a tissue are maintained. 162/209 Gene Ontology BP GO:0098727 0.269805637384908 0.318873667958338 2605 3228.45454545455 2808 0.0281811559974708 2219 1.1605347749888 1.16499858666733 1 1.95888279279683 2602 4651 2808 4096 2219 3977 2630 4308 2446 2517 3259 3113 M16095 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. 26/46 Gene Ontology BP GO:1903170 0.000887536865230964 0.00364493295138542 4465 2635.63636363636 2809 8.07177384456548e-05 381 0.868125886240417 -0.976609482924228 -1 7.22642977733849 4463 1026 2569 2396 381 2960 4307 2164 2809 2850 3067 3114 M11997 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. 442/608 Gene Ontology BP GO:0032388 0.668637237993712 0.691390059851284 2525 2869.54545454545 2810 0.0955360831064704 1689 0.973005736318144 1.01939564184893 1 0.522523176143399 2524 2467 3428 1689 4117 2810 2477 3233 1862 3937 3021 3115 M13342 GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. 12/24 Gene Ontology BP GO:0031272 0.32750691360099 0.380211993259832 1730 2814.27272727273 2810 0.0354266544398932 1726 1.33531839970564 1.33531839970564 1 1.90668042710477 1726 3920 2810 4023 3066 1985 1990 2293 3692 2581 2871 3116 M16427 GO_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATED_EXOCYTOSIS.html A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. 224/351 Gene Ontology BP GO:0045055 4.05399608769882e-05 0.000380146911810331 3490 2612.72727272727 2810 3.68551890331414e-06 305 1.20413536613932 -1.25916950038283 -1 14.069251130522 3487 1966 305 2498 1501 4056 2810 3909 3590 483 4135 3117 M12819 GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 210/257 Gene Ontology BP GO:0051495 0.499046363823438 0.548821255228186 2670 2874.81818181818 2811 0.0609064305808353 1557 1.07801453132795 1.01611792674693 1 0.949710186409296 2666 2520 2811 2954 3557 2904 2784 3662 2352 1557 3856 3118 M11589 GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 859/1065 Gene Ontology BP GO:0044087 0.6513215599 0.691390059851284 2385 2635.45454545455 2813 0.1 892 1.08621877869034 1.12900874919913 1 0.584561453082311 2382 1302 4314 892 2936 3225 2813 3119 2340 2067 3600 3119 M12904 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune system process. 782/1372 Gene Ontology BP GO:0002684 0.000982042822854947 0.0039189067364872 2025 2704 2814 9.82477076615603e-05 347 1.15775889015898 1.20341889633766 1 9.51635278417798 2024 1895 4393 1962 3855 3238 2682 2814 3217 347 3317 3120 M10893 GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. 6/48 Gene Ontology BP GO:0042738 0.192541238375779 0.235823738394973 2065 2764.54545454545 2815 0.0211592634783126 1495 2.02417381848764 -2.30399181805524 -1 4.33137279855452 2061 3268 4269 2815 2603 3240 2067 2950 4070 1572 1495 3121 M12160 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). 663/904 Gene Ontology BP GO:0006366 0.381552698383732 0.433819064876804 1585 3315.90909090909 2815 0.046917994732193 1585 0.988673228734662 0.979122683095469 1 1.21531450637089 1585 4619 4347 4588 4295 2442 1941 2815 2803 4250 2790 3122 M12194 GO_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. 137/235 Gene Ontology BP GO:0009913 0.000383271623212148 0.00200829151216906 2815 2511 2815 3.48489464480209e-05 432 1.43916602568803 -1.7363017501737 -1 13.2605972856156 2815 2548 432 3271 4055 2731 3850 2849 3122 702 1246 3123 M11847 GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 100/124 Gene Ontology BP GO:0006023 2.5066787655197e-07 5.2538631963798e-06 1910 2382.81818181818 2816 2.27879913739144e-08 170 1.45934002295158 -1.40905018516193 -1 26.331016173065 1908 1469 170 2474 2816 4331 2956 3068 3105 362 3552 3124 M12283 GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that activates or increases the activity of an enzyme. 1483/1913 Gene Ontology BP GO:0043085 0.0152077051292968 0.028613607750351 2700 2675.45454545455 2817 0.00153127921349623 598 1.10927917214524 1.15666484554674 1 5.84288920040431 2696 1262 4359 699 3709 3693 3182 2817 2416 598 3999 3125 M13207 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS.html Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 36/38 Gene Ontology BP GO:0036003 0.297173370596398 0.348474721115181 1930 3166.81818181818 2817 0.0315502088603831 1768 1.03513167184796 1.07508213554788 1 1.60962090506718 1926 4424 2817 4613 4268 2623 2902 2398 4351 2745 1768 3126 M13924 GO_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 43/54 Gene Ontology BP GO:0034605 0.377432382114645 0.430544955621339 3975 2978.18181818182 2817 0.0421672454334849 1705 1.17095997968714 -1.25597885892977 -1 1.45452608190129 3975 3394 2653 2452 3448 1705 3542 2681 3430 2817 2663 3127 M11113 GO_FERRIC_IRON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERRIC_IRON_TRANSPORT.html The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 36/44 Gene Ontology BP GO:0015682 0.132676424825748 0.170442684901768 3405 2526.09090909091 2818 0.012856921680393 423 1.01522560480419 1.2124666893413 1 2.65653099818369 3404 1619 2818 1346 1862 3535 3457 4125 423 2001 3197 3128 M14411 GO_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. 43/46 Gene Ontology BP GO:0097581 0.43119990772354 0.48137552078638 4440 2845.90909090909 2818 0.05 211 1.01762571088251 -0.990096665778321 -1 1.09404170664439 4436 211 2640 784 4419 3425 4137 2748 2290 2818 3397 3129 M12537 GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE.html Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. 10/13 Gene Ontology BP GO:0099500 0.0298716210939361 0.0490446905257885 3545 2622.54545454545 2819 0.00275319089495758 1237 0.834880351052746 -0.891666555700989 -1 3.72692716259801 3543 1237 2929 2067 1264 2977 2819 2543 3403 3618 2448 3130 M16469 GO_TRIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 36/44 Gene Ontology BP GO:0072512 0.132676424825748 0.170442684901768 3405 2533.27272727273 2819 0.012856921680393 424 1.01522560480419 1.2124666893413 1 2.65653099818369 3405 1620 2819 1347 1863 3536 3458 4189 424 2007 3198 3131 M14750 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. 28/30 Gene Ontology BP GO:1904376 0.000129185206854635 0.00091911126528229 2820 2247.09090909091 2820 1.17447993913208e-05 152 0.913035413845035 1.02895630969551 1 9.46854828162791 2820 294 2875 1324 152 3042 3491 2802 1233 3394 3291 3132 M15086 GO_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 17/21 Gene Ontology BP GO:0010463 0.109131501161327 0.144124449092773 2540 2885.81818181818 2820 0.0104503256150844 1287 1.26856357484139 -1.16658600816072 -1 3.63801999711068 2540 2820 1287 3379 2792 3512 3412 3644 3208 2556 2594 3133 M15764 GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. 294/617 Gene Ontology BP GO:0002768 0.683069019699172 0.691390059851284 4390 2917.81818181818 2820 0.0991900927018392 623 0.993123650600507 -0.89303815556434 -1 0.533547354202137 4390 653 2820 623 4152 2375 4421 4588 2896 2508 2670 3134 M15910 GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE.html Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. 10/13 Gene Ontology BP GO:0031629 0.0298716210939361 0.0490446905257885 3545 2620.09090909091 2820 0.00275319089495758 1238 0.834880351052746 -0.891666555700989 -1 3.72692716259801 3544 1238 2930 2068 1265 2978 2820 2499 3404 3626 2449 3135 M16531 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. 28/30 Gene Ontology BP GO:1903077 0.000129185206854635 0.00091911126528229 2825 2245.36363636364 2821 1.17447993913208e-05 153 0.913035413845035 1.02895630969551 1 9.46854828162791 2821 295 2876 1325 153 3043 3492 2772 1234 3396 3292 3136 M12421 GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. 27/47 Gene Ontology BP GO:2001258 0.262247932981603 0.311285620449847 3830 3108.36363636364 2822 0.027271013391232 2203 0.942740888731498 -0.944427822127146 -1 1.62297760314128 3830 2235 2584 2413 2203 2881 4049 4133 2822 2502 4540 3137 M15867 GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 23/28 Gene Ontology BP GO:0048261 0.016622698579168 0.030692625590821 2320 2533.72727272727 2823 0.00152269461388699 327 1.08640998772192 0.799904549453353 1 5.60906561522635 2317 3146 2823 1934 3883 1537 327 3536 2445 3062 2861 3138 M15914 GO_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. 492/738 Gene Ontology BP GO:0030855 3.14469662745638e-12 2.48004634026348e-10 3100 2149.81818181818 2824 2.85881511587353e-13 41 1.26464697633889 1.17551347643474 1 41.5214018767918 3098 605 41 286 3856 2824 3023 3668 2412 49 3786 3139 M13765 GO_REGULATION_OF_GROWTH_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. 11/17 Gene Ontology BP GO:0060123 0.139660768096432 0.178185235523087 2825 2645.27272727273 2825 0.0135822368706317 208 1.36325339784785 1.45720943950668 1 3.48094301809487 2825 3593 3073 3117 2567 2603 2331 4456 208 3099 1226 3140 M12612 GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. 31/40 Gene Ontology BP GO:0045822 0.126032360509049 0.16316877391447 3380 2471.54545454545 2827 0.0121718553931251 967 1.17955087769414 -1.11618232176864 -1 3.16463219205495 3380 967 1327 1833 2827 3646 4003 1764 2894 1567 2979 3141 M13028 GO_REGULATION_OF_HEXOKINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEXOKINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hexokinase activity. 12/14 Gene Ontology BP GO:1903299 0.262624957307414 0.31157417806002 3530 2879.18181818182 2827 0.0273162155331324 537 1.15000777055728 -1.28280468385688 -1 1.9805604538961 3527 2382 3034 2827 4641 2300 4481 2154 537 3195 2593 3142 M15832 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of endothelial cell proliferation. 81/103 Gene Ontology BP GO:0001938 0.000921328007496764 0.00374078465871068 3865 2730.45454545455 2827 8.37921884215572e-05 494 1.43840244556906 1.38195908653775 1 11.9250753168123 2827 2598 494 4162 3563 3862 3073 3863 1903 1208 2482 3143 M12312 GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of adenylate cyclase activity. 44/86 Gene Ontology BP GO:0045761 0.00793486176946583 0.0172205745397969 3385 2580.27272727273 2828 0.000723966020428141 757 1.34093963027027 1.20861845477638 1 8.07635686058374 3385 2158 757 1225 2828 4211 2955 1852 2872 1515 4625 3144 M16287 GO_MESODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the mesoderm. 9/23 Gene Ontology BP GO:0001710 6.94924800301467e-05 0.000572298247044731 1870 2638.36363636364 2828 6.9494653267947e-06 25 1.11014260857049 -0.853474666914093 -1 12.2958435227843 1866 3930 4612 2828 4327 691 1934 25 4466 2891 1452 3145 M11409 GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. 1731/2411 Gene Ontology BP GO:0009891 0.181287192908511 0.223569920117493 1000 2781 2829 0.0198034752391 999 1.07801487029481 1.10165330499423 1 2.38718886203454 999 3952 4297 4138 3634 1716 1412 2179 2829 3134 2301 3146 M11631 GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that activates or increases the rate of neuroblast proliferation. 24/33 Gene Ontology BP GO:0002052 0.00644872527022707 0.0146439813977582 4150 3170.45454545455 2829 0.00058797326920166 803 1.07849670755019 1.25751244039679 1 6.75314530714995 4149 2269 2829 2724 803 4212 4457 4074 2058 2686 4614 3147 M12857 GO_POSITIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_GROWTH.html Any process that activates or increases the frequency, rate, extent or direction of cell growth. 174/233 Gene Ontology BP GO:0030307 0.00214617546338912 0.00683983180215723 3720 2661.81818181818 2829 0.000195297454096732 393 1.29907577040922 -1.34506895696381 -1 9.60492175972534 3719 2004 822 1576 2829 4561 4017 3299 1656 393 4404 3148 M15281 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT.html Any process that modulates the frequency, rate or extent of actin filament-based movement. 44/71 Gene Ontology BP GO:1903115 0.00840311105067473 0.0180393124037278 2830 2602.09090909091 2829 0.000766852748107298 764 1.26324681772092 -1.31912226688422 -1 7.52067852895752 2829 914 764 1805 2874 4642 3726 3660 2493 1223 3693 3149 M14176 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a ventricular cardiac muscle cell. 16/30 Gene Ontology BP GO:0086005 0.00194222218215148 0.00639120213122408 510 2153 2830 0.000176721723002224 63 1.17749385489382 1.01086357857155 1 8.82360004956007 509 2830 1674 3482 4418 3268 1018 411 3011 2999 63 3150 M10446 GO_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 1272/1714 Gene Ontology BP GO:0044248 0.16952571019057 0.21079720190185 4000 3058.63636363636 2831 0.0184043634023281 1878 1.00684144907034 -0.982464988317114 -1 2.31682296804039 3998 1878 4240 2249 2035 2666 4248 3348 1934 4218 2831 3151 M15056 GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. 69/101 Gene Ontology BP GO:0042475 0.000133111791246644 0.000939862161867427 2925 2450.81818181818 2832 1.21018041732497e-05 366 1.40952541849194 1.44593257698576 1 14.5764232757818 2922 1525 366 1037 3295 4179 4298 2832 1989 720 3796 3152 M16344 GO_FOLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 20/20 Gene Ontology BP GO:0046655 0.0940967429904784 0.12709205954563 3985 2668.36363636364 2832 0.00894365264352646 249 1.85506212957427 -1.76864575869878 -1 5.67134060626647 2515 3831 2550 2990 4317 1152 951 3981 249 2832 3984 3153 M10270 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 10/25 Gene Ontology BP GO:0044550 0.0187225392776834 0.0337005706998301 2835 2377.90909090909 2833 0.00171670884200742 583 1.21991491094136 -1.55061804375138 -1 6.13030444551483 2833 3252 3015 3049 1922 2220 3490 839 583 3614 1340 3154 M16423 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 16/33 Gene Ontology BP GO:0090208 0.000238704515175172 0.0014407409156256 4425 2401.90909090909 2833 2.17027653672664e-05 149 1.24476542567128 -1.34237400807074 -1 12.0817918937309 4423 2833 2874 1543 206 1920 3670 1992 149 3009 3802 3155 M16535 GO_CORTICAL_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. 57/61 Gene Ontology BP GO:0030865 0.00577426225782821 0.0134540021460564 3480 2560.63636363636 2833 0.000526315789473684 175 1.17672913885379 -1.27001450739115 -1 7.51729517393361 3478 1550 2184 175 4099 3670 3371 2833 1504 767 4536 3156 M15080 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes outside the context of DNA replication. 44/63 Gene Ontology BP GO:0006336 0.171237105971985 0.212357743626771 1995 2555.54545454545 2836 0.0169297069113207 624 1.24537686724734 -1.55214141985842 -1 2.85459917247007 1991 3059 3155 2836 3897 1487 1310 3209 624 3717 2826 3157 M16465 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures, occurring outside the context of DNA replication. 44/63 Gene Ontology BP GO:0034724 0.171237105971985 0.212357743626771 1995 2557.18181818182 2837 0.0169297069113207 625 1.24537686724734 -1.55214141985842 -1 2.85459917247007 1992 3060 3156 2837 3898 1488 1311 3216 625 3719 2827 3158 M12742 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. 72/101 Gene Ontology BP GO:0032088 0.580357428879742 0.627708767219303 2540 2870.90909090909 2838 0.0759056354975781 2536 0.90113833026802 0.981611241650831 1 0.612433048693558 2536 2605 3373 2838 2706 3036 3263 2951 3089 2549 2634 3159 M14795 GO_PHOSPHOLIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORT.html The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. 50/68 Gene Ontology BP GO:0015914 0.00577426225782821 0.0134540021460564 4405 2465.63636363636 2838 0.000526315789473684 83 1.04869759453819 -1.06573000308322 -1 6.69823151263206 4404 176 1630 83 1085 3578 3951 4444 2838 1038 3895 3160 M12528 GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING.html Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. 16/18 Gene Ontology BP GO:0006349 0.00135767978238863 0.00495473257055241 3040 2477.36363636364 2840 0.000123501669825891 444 1.1376487778553 0.900340846864736 1 8.95469744094337 3037 2840 2841 3808 444 2256 1562 590 4345 3501 2027 3161 M12655 GO_BEHAVIORAL_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_PAIN.html Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 16/32 Gene Ontology BP GO:0048266 0.00169041762397619 0.00582199348953458 890 2622.90909090909 2841 0.000153792535626384 482 1.05804018609229 1.06319415355284 1 8.07393046300967 889 2841 1958 4163 482 2965 3175 2771 4326 2994 2288 3162 M14247 GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 15/27 Gene Ontology BP GO:0071360 0.00280826857697478 0.00832594521514136 4570 2673.63636363636 2842 0.000255623610089715 573 1.13360890384405 1.00041191744382 1 8.04921525829113 4566 2842 2372 3315 573 3733 4254 734 1320 1766 3935 3163 M14514 GO_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. 22/26 Gene Ontology BP GO:0030219 0.0301343042732176 0.0493682876008572 2845 2891.81818181818 2842 0.00277774174214454 503 1.18309510063436 -1.41359661551444 -1 5.27426131779529 2842 4159 2390 3819 4501 2819 3189 1026 4029 2533 503 3164 M12866 GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. 1850/2715 Gene Ontology BP GO:0071310 3.58050813759951e-05 0.000343507306479392 1955 2633.81818181818 2843 3.58056582908112e-06 188 1.14313730943384 1.18164391995374 1 13.5280298176182 1953 1872 4391 3685 3000 2993 2706 2008 2843 188 3333 3165 M10481 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. 15/19 Gene Ontology BP GO:2001028 0.0829842468581033 0.114339858048787 4380 2980.81818181818 2844 0.00784458103460738 1236 1.15539213339433 -0.908486346381424 -1 3.70966837057275 4380 2844 1236 3743 1658 2702 4257 1563 3842 2366 4198 3166 M11991 GO_RESPONSE_TO_METHYLMERCURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METHYLMERCURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. 12/14 Gene Ontology BP GO:0051597 0.300684365214075 0.352325447328403 3285 2644.36363636364 2844 0.0319910220219132 1325 1.07323216632558 -1.27503173004318 -1 1.65174661144995 3281 3577 2844 2855 2436 1534 2074 2553 1325 3191 3418 3167 M12251 GO_POLYAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. 15/17 Gene Ontology BP GO:0006595 0.0210793995976115 0.0369877146334738 2845 2457.45454545455 2844 0.00193492039566806 326 1.1180527520129 1.03663584413254 1 5.46302844531877 2844 4205 3200 3510 1233 326 393 4434 1953 3440 1494 3168 M14522 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 38/45 Gene Ontology BP GO:1902042 0.150602353858748 0.190163569200747 3365 3053.54545454545 2844 0.0147293400162436 1926 1.24390362413426 1.33154346042353 1 3.05509417972324 3363 4413 2529 4390 1926 2844 2115 3085 3697 2514 2713 3169 M13288 GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. 12/17 Gene Ontology BP GO:0030007 0.00952116580831649 0.019961428181669 1920 2565.18181818182 2846 0.000869329358085878 233 0.989953832427142 -0.967386285855261 -1 5.74250884520241 1917 3916 1808 4505 2846 839 233 2943 3883 3197 2130 3170 M15344 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. 17/31 Gene Ontology BP GO:0035235 0.125431759278274 0.162572138139779 2165 2473.45454545455 2846 0.0121101612475374 720 1.32112853427903 1.6297139687495 1 3.55293855194152 2163 3196 1926 3216 3107 1714 2846 3625 720 3539 1156 3171 M15560 GO_EPITHELIAL_STRUCTURE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_STRUCTURE_MAINTENANCE.html A tissue homeostatic process required for the maintenance of epithelial structure. 26/49 Gene Ontology BP GO:0010669 0.221970012215715 0.267433057182735 1995 3080.81818181818 2846 0.0225589461368827 1495 1.29684597797024 1.18658361577585 1 2.52897858708582 1995 4490 1495 4572 4059 3129 1744 2416 4411 2846 2732 3172 M16398 GO_APOPTOTIC_MITOCHONDRIAL_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_MITOCHONDRIAL_CHANGES.html The morphological and physiological alterations undergone by mitochondria during apoptosis. 76/85 Gene Ontology BP GO:0008637 0.185653627168697 0.228358254730861 2815 2620.90909090909 2848 0.0184967490985757 801 0.932889907933257 -0.745889328299386 -1 2.03503021734962 2812 832 2980 2848 3936 1217 2963 4332 801 3452 2657 3173 M15568 GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 92/182 Gene Ontology BP GO:0033559 4.05745026247981e-07 7.99971019971125e-06 4270 2246.63636363636 2849 3.68859182799432e-08 170 1.40545814625011 -1.29128121797843 -1 24.4810208823383 4268 793 180 688 3539 3622 3722 3228 1654 170 2849 3174 M13391 GO_VITAMIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 14/24 Gene Ontology BP GO:0009110 0.18858568571154 0.231710904572431 4280 3010.18181818182 2850 0.0188185404301691 1021 1.21154925652739 -1.4475916927859 -1 2.61987069082434 4279 2850 2440 1544 2041 3936 3944 3980 1021 2791 4286 3175 M12284 GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. 24/25 Gene Ontology BP GO:1901798 0.00338879506533131 0.0095873528605544 3230 2704.27272727273 2852 0.00030854784719377 617 1.25493578627344 -1.22294596361873 -1 8.64897886807938 3229 3496 2786 4340 617 2852 3549 1404 3679 2687 1108 3176 M16182 GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-alpha production. 34/57 Gene Ontology BP GO:0032647 0.0255891149181053 0.0434865418969847 1965 2859.90909090909 2852 0.00235379012031819 954 0.955503252708093 1.05864680624438 1 4.43758045545347 1962 4106 2852 3853 2791 3018 1553 954 4093 3632 2645 3177 M11656 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL.html A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. 109/138 Gene Ontology BP GO:0070646 0.0168991530341195 0.0311043350742714 805 2720.45454545455 2853 0.00154821601005034 802 0.738727814653157 0.825723003290341 1 3.79597654792857 802 2990 4137 3842 1064 2310 1753 2234 3723 4217 2853 3178 M11576 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. 9/16 Gene Ontology BP GO:1904406 0.0864139155294946 0.118329590629411 4335 2662 2854 0.00899704931381284 541 1.16006492849537 -1.14962383336818 -1 3.66563525078462 4331 541 4312 1108 3660 4076 2854 2219 684 932 4565 3179 M12785 GO_PEPTIDYL_THREONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_THREONINE_MODIFICATION.html The modification of peptidyl-threonine. 79/87 Gene Ontology BP GO:0018210 0.43119990772354 0.48137552078638 2990 2465.09090909091 2854 0.05 90 0.879223923906078 0.929992048968528 1 0.943796810714358 2405 90 2987 1399 4009 3130 2375 2990 2017 2860 2854 3180 M12164 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 9/16 Gene Ontology BP GO:0045019 0.0864139155294946 0.118329590629411 4335 2674.09090909091 2855 0.00899704931381284 542 1.16006492849537 -1.14962383336818 -1 3.66563525078462 4332 542 4350 1109 3661 4077 2855 2305 685 933 4566 3181 M11225 GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. 342/480 Gene Ontology BP GO:1903651 0.68618940391 0.691390059851284 2530 2741.90909090909 2856 0.1 1161 1.02139245406287 1.04040412486363 1 0.549038041681095 2530 1936 3227 1161 4372 2921 2581 3582 1745 3250 2856 3182 M14694 GO_COCHLEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_DEVELOPMENT.html The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. 45/75 Gene Ontology BP GO:0090102 0.0256781323470351 0.0435782926899205 2860 2806 2857 0.00236207592756964 952 1.31304381176076 1.46510566456206 1 6.09796312455858 2857 2168 952 3319 4137 2093 1999 4504 3262 1296 4279 3183 M16601 GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 243/322 Gene Ontology BP GO:0034599 0.084782317988114 0.116403695957124 2860 2828.09090909091 2858 0.00802159375563188 1670 1.03486361640219 1.04322469991268 1 3.29408156689264 2858 2955 1919 3558 1670 2828 2756 3605 3652 2080 3228 3184 M10980 GO_CELLULAR_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 14/24 Gene Ontology BP GO:0071276 0.00144239780036439 0.00516976539496155 2825 2733.27272727273 2860 0.000131213123301706 460 1.18338967018518 -1.48560903167245 -1 9.24051310989078 2822 2860 1606 3251 460 3903 3677 2076 4172 1628 3611 3185 M11738 GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. 186/242 Gene Ontology BP GO:0043409 0.46035635349659 0.509645042307788 2290 2996.36363636364 2860 0.0545336051739513 1854 1.08326015817743 1.11600651787745 1 1.07350300037477 2288 3638 3198 3839 4605 2860 2054 3731 2560 1854 2333 3186 M12505 GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of T cell tolerance induction. 24/53 Gene Ontology BP GO:0002664 0.0233821348268188 0.0402653861395959 1865 2679.36363636364 2860 0.0021485825111085 1179 0.952886603717688 -1.03416644733691 -1 4.53428670356972 1864 2763 2860 1578 1179 2943 3685 2606 3532 3526 2937 3187 M11046 GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION.html Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. 13/17 Gene Ontology BP GO:0032928 0.000154555933839426 0.00104132677153963 3735 2745.45454545455 2861 1.40515266253353e-05 166 1.09496768450813 -1.07271504374261 -1 11.1544084869709 3733 2861 1989 2115 166 4036 3945 3772 1461 1496 4626 3188 M14681 GO_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMETE_GENERATION.html The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. 529/1037 Gene Ontology BP GO:0007276 0.64075030939653 0.685539477954025 3075 2872 2862 0.0973079029659844 1327 1.07865432168869 1.00013719208002 1 0.594026949012282 3073 1327 4511 1764 2862 2803 2777 3492 1820 2948 4215 3189 M11183 GO_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE.html Any process that modulates the frequency, rate or extent of a defense response. 740/1123 Gene Ontology BP GO:0031347 0.00584499601972777 0.0135683435389237 2865 2560.27272727273 2864 0.000586042696348305 493 1.18572464753562 1.27026249167786 1 7.55994310071839 2495 589 4284 707 3963 3548 2865 2800 2864 493 3555 3190 M12545 GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. 46/62 Gene Ontology BP GO:1903523 0.0464533849474187 0.0701550146576888 4230 2709.18181818182 2864 0.00431493351484651 1077 1.11745367654089 -1.07467491162673 -1 4.39798760434117 4229 1578 1077 1356 1985 4175 4028 2864 2916 1340 4253 3191 M15365 GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS.html Any apoptotic process that contributes to the shaping of an anatomical structure. 23/28 Gene Ontology BP GO:0060561 0.676890333464643 0.691390059851284 1695 2779.63636363636 2864 0.0976075561643919 669 1.15437776163513 1.2124471965177 1 0.621911088523628 3361 1693 2415 1693 2864 3876 3541 4393 669 2609 3462 3192 M12902 GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 14/15 Gene Ontology BP GO:1902895 0.00194464752784503 0.00639466073997378 2785 3002.09090909091 2865 0.000176942599243941 507 0.81844970337207 -0.902803806460906 -1 6.12917873287156 2785 2865 2845 3783 507 4543 2708 2036 3915 3361 3675 3193 M14087 GO_RESPONSE_TO_VITAMIN_A http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_A.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. 18/32 Gene Ontology BP GO:0033189 0.357324325231177 0.410019749765885 4000 2625 2865 0.0393952833163177 490 1.5157412606205 1.32575951571436 1 1.99587569009664 3996 2314 1652 1827 2920 3432 3832 3412 490 2135 2865 3194 M14535 GO_PIRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. 3/15 Gene Ontology BP GO:0034587 0.344590596664293 0.39687624907895 3255 2832.18181818182 2866 0.0413694463216239 562 0.979054575091258 0.979054575091258 1 1.33277349416488 3253 562 4499 1492 3095 2501 1851 4503 1951 4581 2866 3195 M15697 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction. 84/122 Gene Ontology BP GO:0055117 0.0139874794740088 0.0267476357641187 2870 2910.63636363636 2866 0.00127974643957337 840 1.13353661357966 -1.17290328185646 -1 6.08439589634789 2866 2088 840 2860 4321 3508 3940 2732 3487 1126 4249 3196 M15341 GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of cell projection assembly. 197/259 Gene Ontology BP GO:0060491 0.00577426225782821 0.0134540021460564 4245 2804.45454545455 2867 0.000526315789473684 217 1.0920548687339 -1.07230933207114 -1 6.97560353010347 4245 1983 2867 217 2383 4119 4299 4337 1412 1865 3122 3197 M10629 GO_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 44/53 Gene Ontology BP GO:0070670 0.0290669921521115 0.0480969823911006 4325 2843.63636363636 2868 0.00267802640125509 1009 1.17775200506139 0.861377918934211 1 5.29601667425589 4322 4386 2181 3570 2198 3111 1937 1009 3273 2868 2425 3198 M11869 GO_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORT.html The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 568/954 Gene Ontology BP GO:0006812 2.42652683963299e-05 0.000260152750802127 4530 2501.36363636364 2868 2.42655333618646e-06 175 1.18684543189824 -1.156144406171 -1 14.5354874410786 4526 595 4329 244 3590 1777 4296 3457 1658 175 2868 3199 M11626 GO_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 753/1387 Gene Ontology BP GO:0050776 0.00483704476722276 0.0122938055352984 2870 2773 2869 0.00048476057858166 480 1.13638072202474 1.15557954841413 1 7.41133736357501 2649 1307 4317 769 3816 3955 2869 3313 2866 480 4162 3200 M11722 GO_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. 376/485 Gene Ontology BP GO:0016055 0.448293696940057 0.497711899752347 4470 2806.72727272727 2869 0.0526315789473684 315 0.990795135396419 -0.948459445969221 -1 1.01581706463358 4467 623 2869 315 4154 2502 4465 4389 1522 3083 2485 3201 M15951 GO_ORGANELLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_LOCALIZATION.html Any process in which an organelle is transported to, and/or maintained in, a specific location. 495/627 Gene Ontology BP GO:0051640 0.0484356403481738 0.0726066477255324 3390 2796.54545454545 2869 0.00450328008339069 1450 0.979257663939447 -1.00260875009665 -1 3.80282297963863 3389 2460 3993 2869 1450 1883 3218 3419 2091 4207 1783 3202 M11021 GO_ADULT_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_WALKING_BEHAVIOR.html The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 43/79 Gene Ontology BP GO:0007628 0.0390464049433202 0.0610904244119936 925 2637.72727272727 2870 0.00361428535912126 923 1.03218207682852 0.987310668418742 1 4.27360916068105 923 3066 2870 3384 1358 1569 1647 4569 3457 3453 2719 3203 M11839 GO_AMEBOIDAL_TYPE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMEBOIDAL_TYPE_CELL_MIGRATION.html Cell migration that is accomplished by extension and retraction of a pseudopodium. 192/270 Gene Ontology BP GO:0001667 1.13072231169084e-07 2.67485477710262e-06 3010 2364.81818181818 2870 1.02792942709634e-08 148 1.26567932150462 -1.29745226477965 -1 24.1040309271169 3006 1398 148 2011 1118 3551 4245 4081 2870 501 3084 3204 M12355 GO_ATRIAL_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_DEVELOPMENT.html The progression of the atrial septum over time, from its initial formation to the mature structure. 19/26 Gene Ontology BP GO:0003283 0.000294398410553336 0.00169324574079688 1945 2560.45454545455 2870 2.67670739620734e-05 221 1.1768852053497 1.39934095821456 1 11.1401604397358 1945 3843 2923 3825 221 2870 2379 3525 822 3226 2586 3205 M12488 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. 33/44 Gene Ontology BP GO:1904036 0.369725823250664 0.422582720605585 1675 3013.18181818182 2870 0.0410953815805932 1674 1.36624787248821 1.19043841634621 1 1.73675202668013 1674 4447 2213 4547 2870 2841 1848 2994 4125 2541 3045 3206 M10268 GO_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 951/1356 Gene Ontology BP GO:0060429 3.18097442847992e-14 5.48187926508039e-12 2300 2431.45454545455 2871 3.18097442847997e-15 9 1.25318322542976 1.16221921175511 1 48.2381541636615 2297 1288 4234 683 3490 2996 2871 2745 2879 9 3254 3207 M13840 GO_REGULATION_OF_EXOSOMAL_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOSOMAL_SECRETION.html Any process that modulates the frequency, rate or extent of exosomal secretion. 18/20 Gene Ontology BP GO:1903541 0.208507739695838 0.252455506844843 3920 2702 2871 0.021033390206496 472 0.834410016000726 -0.72392269801325 -1 1.69478668254323 3917 1756 3503 1644 3037 2871 2292 2035 472 3597 4598 3208 M16566 GO_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_WALKING_BEHAVIOR.html The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 43/79 Gene Ontology BP GO:0090659 0.0390464049433202 0.0610904244119936 925 2638.63636363636 2871 0.00361428535912126 924 1.03218207682852 0.987310668418742 1 4.27360916068105 924 3067 2871 3385 1359 1570 1648 4568 3458 3455 2720 3209 M10682 GO_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CYCLE.html The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. 98/143 Gene Ontology BP GO:0042633 0.00217787909678784 0.00690775149103873 2875 2690.36363636364 2872 0.000198185279106384 581 1.38698895037751 1.15698240817421 1 10.2352938726949 2872 2576 581 3096 3714 3442 2506 2103 3745 1511 3448 3210 M15323 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. 12/25 Gene Ontology BP GO:0002689 0.00093815260054613 0.00378925698814335 3695 2328.27272727273 2872 8.53229907977444e-05 332 1.82105035082868 -1.19611227986177 -1 15.0654420872552 3691 1187 496 480 4449 2872 4314 3739 332 893 3158 3211 M13884 GO_MOLTING_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLTING_CYCLE.html The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. 98/143 Gene Ontology BP GO:0042303 0.00217787909678784 0.00690775149103873 2875 2711.18181818182 2873 0.000198185279106384 582 1.38698895037751 1.15698240817421 1 10.2352938726949 2873 2577 582 3097 3715 3443 2507 2322 3746 1512 3449 3212 M13377 GO_GRANULOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_ACTIVATION.html The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 21/32 Gene Ontology BP GO:0036230 0.0476331255906116 0.0715650414507961 3500 2819.72727272727 2874 0.00442698517073219 1250 1.40518405887666 -1.887929413499 -1 5.49164074434736 3500 3839 2843 2694 2958 2621 1854 1250 2874 2926 3658 3213 M15169 GO_BLASTOCYST_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_GROWTH.html An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. 15/17 Gene Ontology BP GO:0001832 0.00953179236072568 0.019961428181669 3600 2713.09090909091 2875 0.000870303851509601 639 0.694350462752722 -0.714775620381133 -1 4.02459347360436 3600 2835 3714 2162 894 3185 1755 2875 639 3882 4303 3214 M13192 GO_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE.html Any process that modulates the frequency or rate of heart contraction. 104/161 Gene Ontology BP GO:0002027 2.04370511428111e-05 0.000228042203758993 1480 2542.81818181818 2876 1.85793099969735e-06 223 1.32487910507007 1.20715713405768 1 16.4864063492575 1478 3323 277 4352 4132 3848 2876 1731 3960 1771 223 3215 M16961 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. 20/23 Gene Ontology BP GO:0032703 0.0528343268729549 0.0781182468827007 2740 2933 2876 0.00492250419455994 1309 1.18695777022465 -1.2044546632887 -1 4.48270950106372 2737 3507 2742 3521 2876 3722 4081 1309 3093 2834 1841 3216 M16572 GO_LYSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. 13/16 Gene Ontology BP GO:0006553 0.0609760583257336 0.0881669254868419 4525 2765.63636363636 2877 0.00570315700152958 618 1.35104041672034 -1.66234187891015 -1 4.86111378926141 4522 2872 2877 2831 2983 3250 3219 1373 618 2709 3168 3217 M16642 GO_SYNAPSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSIS.html The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. 19/41 Gene Ontology BP GO:0007129 0.0404516785582694 0.0626987542743596 2240 2601.09090909091 2878 0.00374683609360836 778 0.853778566981015 -0.999155613377333 -1 3.50016735940314 2238 3511 3491 2878 3617 1539 2168 1166 3194 4032 778 3218 M13243 GO_TOXIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. 9/16 Gene Ontology BP GO:0009404 0.000144242910976933 0.000992843586946256 2980 2667.18181818182 2879 1.44252274540157e-05 175 1.40839539345663 -1.71138523823589 -1 14.4500459863456 2980 3259 4416 2535 175 2701 3150 2879 4253 1468 1523 3219 M10096 GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION.html The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle. 12/18 Gene Ontology BP GO:0002031 0.0626348277459632 0.0899783431620767 3945 2943.90909090909 2880 0.00586295881298207 562 1.39277796721156 -1.64666425148446 -1 4.96955914316111 3943 2880 2306 2141 1537 4447 3920 4534 562 2573 3540 3220 M14243 GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. 9/13 Gene Ontology BP GO:0052803 0.161679485276062 0.202501923281162 2830 3135.18181818182 2880 0.0174808826663871 1789 2.91413263539064 2.91413263539064 1 6.89956820731635 2826 4592 4482 4317 2558 3367 3118 1935 1789 2880 2623 3221 M16226 GO_NEGATIVE_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_SILENCING.html Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 19/26 Gene Ontology BP GO:0060969 0.533199082691671 0.582525318564063 2855 2945.09090909091 2881 0.066915309781247 885 1.00856043055006 -0.969956524178588 -1 0.798582279503627 2855 3174 2881 2173 2635 3599 3451 4376 885 2251 4116 3222 M10700 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 1857/2850 Gene Ontology BP GO:0048584 3.14196743279207e-09 1.15114759565209e-07 2455 2641.72727272727 2883 3.14196743723444e-10 46 1.17327925361428 1.19091951203995 1 27.82377776861 2451 1253 4256 1168 3034 3602 2883 3556 2669 46 4141 3223 M14263 GO_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APPETITE.html Any process which modulates appetite, the desire or physical craving for food. 11/23 Gene Ontology BP GO:0032098 0.308957737970961 0.361291871017562 3985 2680.81818181818 2883 0.0330377718284836 435 2.1409571402197 -1.31760111482992 -1 3.22573564097631 3985 2883 1609 1560 3900 3928 3306 3229 435 2479 2175 3224 M14783 GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. 25/31 Gene Ontology BP GO:0034394 0.0299718762094802 0.0491572576675048 1485 2679.63636363636 2883 0.00276256020702188 725 0.965434609759723 1.05584197774615 1 4.30810567711891 1483 4137 3291 4173 1268 3616 1912 2883 2423 3565 725 3225 M13509 GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 1102/1576 Gene Ontology BP GO:0044092 0.423071478405696 0.474349780487158 2665 2923.72727272727 2884 0.0535183445261318 1280 1.05538470713858 1.11510404702176 1 1.15807185841887 2664 1280 4431 1979 2520 2884 2959 4328 3195 1814 4107 3226 M16315 GO_CENTROMERE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROMERE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. 37/52 Gene Ontology BP GO:0034508 0.211633491980325 0.255986254264846 1550 2825.90909090909 2884 0.0213854885138499 1455 1.06331880465154 -1.27150248657162 -1 2.14072484059971 1549 4075 3453 4128 3274 1719 1455 2884 2061 3734 2753 3227 M13454 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. 155/259 Gene Ontology BP GO:0031348 0.000250034434618719 0.00148394161260319 3130 2315 2885 2.27329869144123e-05 409 1.28552361342118 1.42741267254121 1 12.4213495574941 3130 734 409 973 3922 3406 3137 2885 2711 454 3704 3228 M15393 GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-glutamate across a membrane. 9/13 Gene Ontology BP GO:0089711 0.0358727422732592 0.0570067861330175 3470 2889.18181818182 2885 0.00364653348893849 1360 1.16355102761789 1.42436131891423 1 4.93841038145507 3466 1857 4550 2047 1360 3323 3486 2688 2466 2885 3653 3229 M15678 GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 12/16 Gene Ontology BP GO:0043455 0.538608524385329 0.587883055117273 4110 3210.45454545455 2886 0.0679035161619875 2122 1.52679305901122 -1.51068067002404 -1 1.1936443416617 4106 2387 2122 3577 2680 4134 2217 4110 2886 2586 4510 3230 M15932 GO_RNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 250/362 Gene Ontology BP GO:0006401 0.114303286422817 0.149902252459235 605 3029.09090909091 2886 0.0109739508136527 604 0.715612247593998 0.709125791058096 1 2.00583850091478 604 4643 4217 4497 2353 1694 1052 2886 4143 4435 2796 3231 M13356 GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. 25/46 Gene Ontology BP GO:0086019 0.0519462371758926 0.0771237528970734 1075 2890.45454545455 2888 0.0048377209411366 1072 1.17453482387143 -1.23712558138774 -1 4.45802547865335 1072 4153 1103 4355 2888 4182 2616 1921 4422 3562 1521 3232 M15433 GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification. 53/71 Gene Ontology BP GO:1903309 0.487817926078388 0.538126318170398 1910 3058.18181818182 2888 0.0590121106489988 1907 0.76103947917706 0.699742799858501 1 0.689564093094949 1907 3365 4040 3857 3533 2245 2105 2773 2888 4272 2655 3233 M15728 GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. 12/23 Gene Ontology BP GO:0016338 0.000823986075689872 0.00346060536608755 4485 2412.27272727273 2888 7.49358956940664e-05 155 2.35364186522755 -1.99235270685571 -1 19.7917256028041 4482 2888 1157 1964 3347 3960 3671 155 387 1376 3148 3234 M12238 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/21 Gene Ontology BP GO:0051589 0.00602046875813153 0.0138610792338377 1780 2713.27272727273 2889 0.000548818875577416 492 0.971856255018502 1.14699369753053 1 6.16363541303567 1776 4503 2889 3329 4368 1252 1315 492 4191 3225 2506 3235 M10086 GO_MEIOTIC_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. 42/69 Gene Ontology BP GO:0045132 0.485835738525625 0.536066798994483 2755 3100.45454545455 2890 0.0586816277847698 1940 0.789861725629463 -0.946714102762308 -1 0.720580425998606 2751 2674 3867 3367 4025 1940 2259 3397 2890 4194 2741 3236 M11255 GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 90/124 Gene Ontology BP GO:0051341 0.208629358353407 0.252537045894485 2400 2788.09090909091 2890 0.0210470662055464 1193 1.08835794926787 1.17229544133609 1 2.21330862813495 2398 1488 1573 4069 4444 2890 2579 3669 2937 1193 3429 3237 M15498 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 34/37 Gene Ontology BP GO:1900101 8.1741566659458e-05 0.000638160251118218 3035 2483.18181818182 2891 7.43132763149222e-06 124 0.758850382048264 -0.797519943711422 -1 8.27884966199314 3033 1642 3425 918 124 2891 3489 1372 4494 3631 2296 3238 M10452 GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. 79/108 Gene Ontology BP GO:0050848 0.0656807987526355 0.0936313592512295 3550 2434.27272727273 2893 0.00615707088456768 83 0.974034470442198 1.14247877327292 1 3.41468177545947 3547 83 1163 1493 1651 3244 2893 3735 3603 1543 3822 3239 M15752 GO_HETEROCHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. 11/13 Gene Ontology BP GO:0070828 0.0131850443965918 0.0256024906121379 1970 2539.81818181818 2894 0.00120588495239443 271 0.808619295249044 -0.808619295249044 -1 4.38984294311551 1967 2894 3255 3501 2475 1725 2910 4084 1753 3103 271 3240 M15572 GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION.html Any process that modulates the frequency, rate or extent of cytoplasmic translation. 17/17 Gene Ontology BP GO:2000765 0.185138623085638 0.227836554672699 3325 2740.09090909091 2896 0.0184403365458127 655 0.949610096628617 -1.16861061678824 -1 2.07492012695906 3323 3191 2896 2062 4407 3641 3915 2074 655 2560 1417 3241 M15586 GO_PROTEIN_ACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACYLATION.html The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. 160/188 Gene Ontology BP GO:0043543 0.0100642515405047 0.0207459293651449 2275 2801 2896 0.000919144464581318 909 0.828171197214472 0.761330353661586 1 4.754897584103 2273 2970 4112 2896 909 2330 1956 3032 2398 4257 3678 3242 M15848 GO_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 495/825 Gene Ontology BP GO:0043269 2.10725320090925e-14 4.2630648451438e-12 2760 2462.45454545455 2896 1.91568472809933e-15 18 1.23620800295079 -1.27032727929599 -1 48.0461598976218 2759 1335 18 2475 2896 3363 3018 3846 2998 153 4226 3243 M16957 GO_DETECTION_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CALCIUM_ION.html The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. 10/20 Gene Ontology BP GO:0005513 0.00137325473688623 0.00499950730935871 3415 2620.54545454545 2897 0.000124919334684931 212 1.11394463947001 -0.959764864184817 -1 8.75301466067691 3411 2897 2031 1071 3299 3192 4213 212 3949 2326 2225 3244 M10903 GO_PHOSPHOLIPID_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 29/34 Gene Ontology BP GO:0046839 0.00106855509204955 0.00416414308484636 4565 2508.81818181818 2899 9.71885863436593e-05 8 1.12689385246652 -1.13663726608124 -1 9.16080692814825 4561 302 2899 116 408 4368 4192 4374 8 2635 3734 3245 M12474 GO_REGULATION_OF_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_PLASTICITY.html A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 166/229 Gene Ontology BP GO:0048167 0.0341596453748152 0.0546765840829085 2975 2820.09090909091 2899 0.00315471546671169 1005 1.25264118237992 1.12361024307394 1 5.39497335497744 2972 4301 1005 2899 3278 2513 2311 4311 2739 1216 3476 3246 M13054 GO_REGULATION_OF_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_LOCALIZATION.html Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. 1317/1866 Gene Ontology BP GO:0060341 0.6493519082533 0.691390059851284 2650 2914.63636363636 2899 0.0994928862378767 1828 1.1088045778665 1.13014014021823 1 0.5969379782142 2646 2435 4404 2037 3051 3358 2899 3290 2212 1828 3901 3247 M10523 GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. 15/19 Gene Ontology BP GO:0048715 0.21361054518887 0.258029560426743 2085 2753.36363636364 2901 0.0216088481635158 1426 1.14523098715943 1.0182811950947 1 2.29293635456185 2083 4534 3036 4089 2226 1426 1461 3643 3319 2901 1569 3248 M14470 GO_LYMPH_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. 15/17 Gene Ontology BP GO:0036303 0.0256981643842978 0.0435922562450374 2790 2748.54545454545 2901 0.00236394061907754 440 1.09639079138809 1.11374441351778 1 5.08951462265682 2790 3900 2901 3807 2438 1634 440 4229 4031 2914 1150 3249 M14902 GO_ORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSPORT.html The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. 9/23 Gene Ontology BP GO:0015695 0.278273993300809 0.327882727482569 4195 2610.90909090909 2902 0.0320849660684544 128 1.05650951584045 -1.23874316672734 -1 1.73863475664731 4193 1240 4522 345 2273 3900 3139 3195 128 2883 2902 3250 M10757 GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of an adaptive immune response. 115/220 Gene Ontology BP GO:0002819 0.186875783242453 0.229731312926587 1990 3036.90909090909 2903 0.0186307516315167 1900 1.02953999457385 0.960527313212211 1 2.23780581156186 1989 4319 2903 4574 3515 2235 1900 1968 4057 2892 3054 3251 M15665 GO_ASPARTATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. 10/12 Gene Ontology BP GO:0006531 0.000683465285310149 0.00304613407332196 3305 2573.36363636364 2903 6.21525188325341e-05 336 1.31231653334617 -0.920749783222425 -1 11.2791041663718 3303 2903 2675 3026 336 3474 3354 1784 1415 2324 3713 3252 M11317 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. 114/144 Gene Ontology BP GO:0097191 0.159775441227397 0.200440854146961 2300 2581.90909090909 2905 0.0157014350352243 1263 0.916604560916703 1.00450833985124 1 2.17678865858135 2299 3660 3511 2960 2734 1463 1263 3207 1352 3047 2905 3253 M13860 GO_REGULATION_OF_MRNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_POLYADENYLATION.html Any process that modulates the frequency, rate or extent of mRNA polyadenylation. 13/13 Gene Ontology BP GO:1900363 0.00227551158364076 0.00713852438319583 2945 2621.81818181818 2905 0.000207078964766818 438 0.656387128748979 0.551520887687776 1 4.80616842342162 2945 1833 3711 2426 543 2905 2470 3733 438 3812 4024 3254 M15182 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. 933/1288 Gene Ontology BP GO:0045944 0.0699220792002477 0.0990704733613741 800 2627 2905 0.00722248265661003 800 1.06991316822748 1.0919036324827 1 3.66214997117832 800 3617 4541 3739 4599 1128 1055 1479 2905 3048 1986 3255 M12451 GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. 12/12 Gene Ontology BP GO:0009396 0.0335402641305045 0.0538705036241759 1870 2534.27272727273 2906 0.0030966174622439 902 0.993693154258015 -0.800964160174678 -1 4.29942572701677 1869 3580 3444 3075 1318 991 902 3187 2906 3755 2850 3256 M12909 GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 90/133 Gene Ontology BP GO:0048259 0.532684373528625 0.582099668865358 1315 3112.27272727273 2907 0.0668218249800003 1312 1.11642741382068 1.03590693243565 1 0.8863439168978 1312 4001 2907 4244 3876 2602 2463 2757 4082 3629 2362 3257 M15204 GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 15/22 Gene Ontology BP GO:0006700 0.00160480509630079 0.00562526308448699 2855 3291.54545454545 2907 0.000145997902662489 472 0.893849910056326 -0.643854398640543 -1 6.86495881587643 2853 4543 2872 4326 472 2867 2907 4114 4559 3883 2811 3258 M10612 GO_CELLULAR_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 84/108 Gene Ontology BP GO:0034644 0.000325197063217726 0.00181247811833771 2910 2608.72727272727 2908 2.95677402520261e-05 236 0.883445487233124 0.772405224085899 1 8.27059723504172 2908 812 3231 2579 236 1988 1062 4096 4145 3644 3995 3259 M11357 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. 30/69 Gene Ontology BP GO:0002716 0.330127481190981 0.382490829178694 1190 2995.81818181818 2908 0.0357689652350351 1188 0.872329349958545 -0.755892500479963 -1 1.23414840867989 1188 4441 2754 3597 2782 1597 2908 3107 4604 3469 2507 3260 M10881 GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. 14/20 Gene Ontology BP GO:0000380 0.0155586947050769 0.0291092104795829 1855 2712.18181818182 2909 0.00142452998132901 347 0.907974158085691 0.564856953537921 1 4.75747198667323 1853 3908 3702 2909 1041 2352 1877 4051 347 3844 3950 3261 M12512 GO_NITROGEN_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_COMPOUND_TRANSPORT.html The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 449/690 Gene Ontology BP GO:0071705 0.603299196956901 0.649502814308298 3510 2692.18181818182 2909 0.0806166305790961 471 1.09287096645068 -1.1212282610545 -1 0.689622282025842 3508 613 2909 471 2753 4468 3339 3749 1514 2245 4045 3262 M15795 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY.html Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. 30/69 Gene Ontology BP GO:0045953 0.330127481190981 0.382490829178694 1190 2998.45454545455 2909 0.0357689652350351 1189 0.872329349958545 -0.755892500479963 -1 1.23414840867989 1189 4442 2755 3598 2783 1598 2909 3123 4605 3473 2508 3263 M12387 GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT.html The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. 58/62 Gene Ontology BP GO:0006893 0.103857882549014 0.138032198657688 2910 2422.63636363636 2910 0.00991922809246897 233 0.849686691907247 -0.931491702054318 -1 2.48772350291998 2910 1542 3837 1552 3445 2035 3172 2988 233 3892 1043 3264 M12894 GO_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXIT_FROM_MITOSIS.html The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. 15/16 Gene Ontology BP GO:0010458 0.165483914255998 0.206472542547722 2825 2644 2910 0.0163112578510446 868 1.40897255225395 1.13139976009477 1 3.28978463140584 2824 3891 3095 3351 1984 1953 1467 3055 868 2910 3686 3265 M14606 GO_APOPTOTIC_DNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_DNA_FRAGMENTATION.html The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. 15/18 Gene Ontology BP GO:0006309 0.091898114140619 0.124556342876872 2405 2766.72727272727 2911 0.00872523026485179 975 0.8976536736236 -0.990719326885915 -1 2.76568722599193 2404 3901 3481 2911 1780 3866 4461 1964 1244 3447 975 3266 M16250 GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that increases the frequency, rate, or extent of monocyte chemotaxis. 14/23 Gene Ontology BP GO:0090026 0.112920952657805 0.148382149877652 4520 2648.90909090909 2911 0.0108337227212054 1117 1.71597260859864 -1.54664811404001 -1 4.85069196434537 4519 3223 1372 1502 1798 2946 3647 2911 1117 1639 4464 3267 M12133 GO_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of vacuolar transport. 37/40 Gene Ontology BP GO:1903335 0.00338344910070666 0.0095873528605544 3290 2707.09090909091 2914 0.000308060349517864 616 0.8744088842934 -0.664617942079459 -1 6.02316595547184 3289 2692 3479 2914 616 2706 2219 3242 1912 3732 2977 3268 M16512 GO_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. 8/16 Gene Ontology BP GO:0036149 0.0182656372589865 0.0330461111727634 2915 2817.63636363636 2914 0.00184175324664899 869 1.29177573348475 -1.34929685189075 -1 6.52966183346665 2914 2416 4628 2033 3738 3852 3320 869 3200 2025 1999 3269 M16324 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. 31/51 Gene Ontology BP GO:0019883 0.355907835164372 0.408595893663909 1070 3035.09090909091 2915 0.0392030011535721 1069 0.7385260764364 -0.744934993426437 -1 0.97081284276282 1069 4456 3347 4067 2359 1659 2533 2915 4639 4063 2279 3270 M15865 GO_GERM_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. 195/412 Gene Ontology BP GO:0007281 0.374635205186446 0.427563799296673 2650 2995.54545454545 2916 0.0417768137141632 1429 1.0411191248626 0.994671768255873 1 1.302801087372 2648 3293 2916 3267 4085 2704 2652 2387 1429 3513 4057 3271 M12404 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 465/586 Gene Ontology BP GO:0044089 0.177958730719893 0.219873067987164 2010 2633.45454545455 2917 0.017657222398167 1431 1.14807428303333 1.13260071307836 1 2.57144724603858 2009 2941 1431 2917 2967 3281 2591 3082 2433 1745 3571 3272 M12614 GO_SULFUR_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 35/44 Gene Ontology BP GO:0044273 0.0485621651271764 0.072772867741305 3320 2842.36363636364 2917 0.00451531410585466 1088 1.35788629860918 -1.37692853382426 -1 5.27269148383482 3317 2695 1088 1975 4019 2917 4235 3783 2351 1524 3362 3273 M11677 GO_REFLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REFLEX.html An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. 24/41 Gene Ontology BP GO:0060004 0.0135345129396238 0.026109489514125 2555 2739.09090909091 2918 0.00123804565851142 999 1.42256762099901 1.34495454202902 1 7.68952939848656 2554 3144 1428 3713 999 4352 4612 1907 2918 1353 3150 3274 M12125 GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. 5/10 Gene Ontology BP GO:0031284 0.00088483205599634 0.00363703494394962 2920 2532.09090909091 2918 8.85184571054858e-05 174 2.24928360696719 -2.24928360696719 -1 18.7476338606665 2918 2926 4344 213 1991 2253 4162 174 4211 3155 1506 3275 M10148 GO_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_FIBER_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. 21/22 Gene Ontology BP GO:0043149 0.00135594208068746 0.00495227511886872 3165 2412.54545454545 2919 0.000123343501837332 374 1.22253526085965 -0.86525874853082 -1 9.62455480408405 3163 3152 2722 3133 442 2634 3249 788 374 2919 3962 3276 M14841 GO_MUSCLE_FIBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FIBER_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. 47/79 Gene Ontology BP GO:0048747 0.387629895009666 0.439360717226549 2920 2989.27272727273 2919 0.0436042564193012 2246 1.02664703656935 -1.09812327887787 -1 1.24305340904634 2919 2662 2246 3025 2417 2255 3121 4369 3895 2398 3575 3277 M11075 GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. 21/22 Gene Ontology BP GO:0030038 0.00135594208068746 0.00495227511886872 3165 2436.90909090909 2920 0.000123343501837332 375 1.22253526085965 -0.86525874853082 -1 9.62455480408405 3164 3153 2723 3134 443 2635 3250 1046 375 2920 3963 3278 M11297 GO_CARBOHYDRATE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHORYLATION.html The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. 21/24 Gene Ontology BP GO:0046835 0.090497926521684 0.123052849826241 3260 2621.09090909091 2921 0.00858637932086255 512 0.998490235413875 -0.92015442338613 -1 3.09556917443786 3257 1097 3318 1063 4114 4273 4400 1547 512 2921 2330 3279 M13668 GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. 463/607 Gene Ontology BP GO:0033157 0.537584586865419 0.586903116537962 2670 2850.36363636364 2921 0.0677156561351364 1342 0.949659507323347 1.04325987213045 1 0.740764130080073 2667 1342 3775 1696 3633 3136 2921 2670 2242 4176 3096 3280 M14285 GO_REGULATION_OF_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACROSOME_REACTION.html Any process that modulates the frequency, rate or extent of the acrosome reaction. 8/28 Gene Ontology BP GO:0060046 0.133579831163045 0.171508541501558 2890 2985.45454545455 2922 0.0142362233007367 1063 1.12104515912457 -0.800200123355486 -1 2.92416254690383 2888 3604 4485 3519 2922 1063 1646 2218 4504 3491 2500 3281 M11550 GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. 5/15 Gene Ontology BP GO:0021521 0.078815950053074 0.109243555435494 3055 2753.72727272727 2923 0.0081759362939413 340 1.33522971027497 -1.33522971027497 -1 4.37913736161184 3051 2923 4310 2690 4629 3527 2862 1859 340 3154 946 3282 M12561 GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 21/50 Gene Ontology BP GO:0071378 3.52199849323758e-05 0.000340703929085955 3635 2436.45454545455 2923 3.20186807133751e-06 80 0.936093042544287 -1.02439148228366 -1 11.0873007441384 3632 1063 3010 664 80 3718 4277 4453 186 2923 2795 3283 M14061 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. 61/86 Gene Ontology BP GO:0032106 0.169881646044223 0.211030771436936 4170 2636.63636363636 2923 0.0167836488186767 124 0.901213589266297 -0.848905275182556 -1 2.07116426975605 4167 124 3426 909 4409 1158 2923 3911 2160 3571 2245 3284 M15830 GO_POST_ANAL_TAIL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_ANAL_TAIL_MORPHOGENESIS.html The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. 32/44 Gene Ontology BP GO:0036342 0.045393290064343 0.0686654677078634 2205 2834.18181818182 2923 0.00421435325507154 1425 1.22986495237346 1.38680952782986 1 4.88067038195518 2204 2212 1977 2923 1425 4243 3740 3363 3148 2859 3082 3285 M15625 GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION.html The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. 5/15 Gene Ontology BP GO:0060573 0.078815950053074 0.109243555435494 3055 2779.45454545455 2924 0.0081759362939413 341 1.33522971027497 -1.33522971027497 -1 4.37913736161184 3052 2924 4565 2691 4630 3528 2863 1871 341 3162 947 3286 M16372 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. 61/86 Gene Ontology BP GO:0032109 0.169881646044223 0.211030771436936 4170 2656.54545454545 2924 0.0167836488186767 125 0.901213589266297 -0.848905275182556 -1 2.07116426975605 4168 125 3427 910 4410 1159 2924 4120 2161 3572 2246 3287 M11471 GO_MANGANESE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_TRANSPORT.html The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/14 Gene Ontology BP GO:0006828 0.0149169978778681 0.0281691522425812 2980 2642.90909090909 2925 0.00150180867963699 749 1.17468106053194 0.68872620338803 1 6.21531355437406 2979 2925 4305 2897 3007 2632 1571 789 749 3302 3916 3288 M12943 GO_PLATELET_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_MORPHOGENESIS.html Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. 23/38 Gene Ontology BP GO:0036344 0.00628097356160084 0.0143613611705792 2715 2813.27272727273 2925 0.000572634333543546 794 0.766080969783203 -0.967844859639554 -1 4.81599307681078 2713 2271 3228 2925 794 4026 4208 1478 3918 3827 1558 3289 M14949 GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS.html The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. 28/37 Gene Ontology BP GO:0046716 0.021536490222204 0.0375878803465548 2735 2610.72727272727 2925 0.0019772957374953 401 1.12112437516036 0.960764282383499 1 5.45127188226027 2734 3456 2925 3128 1157 4230 3116 3627 2229 1715 401 3290 M12000 GO_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule. 45/83 Gene Ontology BP GO:0070988 0.377733909608413 0.430783304266654 1735 3103.36363636364 2926 0.0422094280017652 1735 1.08284074417327 -1.24994158444377 -1 1.34337514933987 1735 4402 3779 4434 4306 2074 1870 2694 1943 3974 2926 3291 M14673 GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 54/68 Gene Ontology BP GO:1901028 0.105667937120612 0.14003785571695 2315 3118 2926 0.0101011947334603 1772 0.7515896220223 -0.764421206019542 -1 2.18318368434332 2315 4042 3460 2716 1772 2229 3156 2926 4485 4279 2918 3292 M13094 GO_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. 1464/1884 Gene Ontology BP GO:0065003 0.358076292197585 0.410781308578739 2195 2977.18181818182 2927 0.0433604284844072 1740 1.00179717137331 -1.04180016257838 -1 1.31275618131092 2806 2935 4407 2074 3459 1740 2927 3689 2193 4326 2193 3293 M14069 GO_CELLULAR_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 5/13 Gene Ontology BP GO:0071294 0.00527443752321241 0.0130960287062472 4475 2885.27272727273 2927 0.000528699836378992 635 0.666165341431932 0.589023941150478 1 4.27771041267824 3895 2927 4472 2866 765 3800 1096 635 2243 4567 4472 3294 M15438 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. 28/30 Gene Ontology BP GO:0033137 0.322587466793585 0.375064756804329 2930 2927.45454545455 2928 0.0347873153720725 1718 1.13650302806344 1.12717148629595 1 1.64420875124485 2928 3454 2204 3490 2313 3368 2536 4561 2630 1718 3000 3295 M16581 GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 137/177 Gene Ontology BP GO:0034614 0.0114952962978585 0.0230351480077243 2980 2620.09090909091 2929 0.00105052762352791 944 1.00645219826888 0.990530152015545 1 5.62436144751044 2976 1433 2064 3109 944 3117 2666 3213 3744 2626 2929 3296 M15733 GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 19/29 Gene Ontology BP GO:1902893 0.000306205909312561 0.00173119817257758 2080 2682.90909090909 2930 2.78407760669801e-05 230 0.848791336922975 0.805581361292631 1 8.00358010381719 2076 2303 3016 3328 230 3982 1970 2930 3560 3243 2874 3297 M10405 GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. 19/30 Gene Ontology BP GO:0001516 0.0442090712102904 0.0672695983754418 2935 2796 2931 0.00410211629361118 787 1.33002739597597 -1.55213457726192 -1 5.31958927058878 2931 3513 1066 3901 4614 2024 787 1555 4402 1732 4231 3298 M13503 GO_MEGAKARYOCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. 19/21 Gene Ontology BP GO:0035855 0.0289480115224915 0.0479512629455867 3235 2600.45454545455 2931 0.00266691661994194 466 1.19111638566727 -1.48525924304206 -1 5.36159997444645 3232 2319 2392 2931 3259 2944 3310 1256 3765 2731 466 3299 M15703 GO_ZINC_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. 19/27 Gene Ontology BP GO:0055069 0.114720185393748 0.150321887535091 2665 3167.54545454545 2931 0.0110162813501308 1805 1.24762836041445 -0.920938997430219 -1 3.49981129450844 2662 3861 2436 3638 1805 4237 4318 2697 3524 2734 2931 3300 M16837 GO_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 132/200 Gene Ontology BP GO:0051592 0.00055937756184664 0.00263666894646289 4160 2597.09090909091 2931 5.08654401135553e-05 455 1.29529859279458 -1.45397522863896 -1 11.4103414066905 4159 2551 455 2983 2931 3683 3109 2328 2320 515 3534 3301 M13034 GO_MULTIVESICULAR_BODY_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 34/34 Gene Ontology BP GO:0036257 0.0204292536700931 0.0361160020239147 3210 2437.36363636364 2932 0.00187467852033329 369 0.674885331470188 -0.726784805928296 -1 3.31729735073451 3207 3092 4033 2932 1207 1575 3895 877 1386 4238 369 3302 M13214 GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS.html The process in which the right cardiac ventricle is generated and organized. 18/27 Gene Ontology BP GO:0003215 0.291587032446505 0.342657278910532 2595 3032.72727272727 2932 0.0308529413147859 2224 1.51494235647115 1.65064023715585 1 2.3985339066471 2593 3874 2280 3654 2932 3168 3558 2224 3614 2650 2813 3303 M16690 GO_PROSTANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. 19/30 Gene Ontology BP GO:0046457 0.0442090712102904 0.0672695983754418 2935 2795.81818181818 2932 0.00410211629361118 788 1.33002739597597 -1.55213457726192 -1 5.31958927058878 2932 3514 1067 3902 4615 2025 788 1538 4403 1738 4232 3304 M16933 GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. 420/511 Gene Ontology BP GO:2001233 0.291837098288663 0.342735491755969 2380 2945.90909090909 2932 0.030884046626734 2227 1.0254045199808 1.10694556272612 1 1.61967962712386 2379 3625 2660 2955 3946 3099 2641 2227 3135 2806 2932 3305 M16077 GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 674/855 Gene Ontology BP GO:1903827 0.368778047498564 0.421706624480418 2615 3144.18181818182 2934 0.0449673714900619 1900 0.980125416036985 1.01209187094664 1 1.24592629413674 2615 1900 4592 2717 4140 3275 2934 2430 2167 4233 3583 3306 M16390 GO_EPITHELIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. 17/23 Gene Ontology BP GO:0072148 0.149616692035839 0.189124278196891 4535 2997.45454545455 2934 0.0146254555097899 1841 1.15812006000424 -1.182233053734 -1 2.85309367525662 4531 3189 2418 2203 2934 3931 3244 1841 1897 2561 4223 3307 M16422 GO_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING_BY_RNA.html Any process in which RNA molecules inactivate expression of target genes. 117/163 Gene Ontology BP GO:0031047 0.542636640685448 0.592140780747981 2800 3091.27272727273 2934 0.0686462449168514 882 0.983467751556609 -0.968898535363373 -1 0.754541111749542 2799 3665 4089 3869 3255 2579 2926 2679 882 4327 2934 3308 M11684 GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html A process in which a protein is transported to, or maintained in, the cell periphery. 183/212 Gene Ontology BP GO:1990778 0.595404204783837 0.64189429213605 3365 2996.81818181818 2935 0.0789681057832435 711 1.00321511478119 -1.02568967776206 -1 0.649725798872089 3364 711 2935 1310 4635 4312 2866 2747 2615 3256 4214 3309 M15982 GO_CHROMATIN_SILENCING_AT_RDNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING_AT_RDNA.html Repression of transcription of ribosomal DNA by altering the structure of chromatin. 18/40 Gene Ontology BP GO:0000183 0.00258870863357528 0.00782159822858816 3880 2800.45454545455 2936 0.000235614523418206 553 1.50251520482539 -2.1070681690016 -1 10.8115212892246 3880 2809 2271 3255 564 2936 4112 4496 553 3152 2777 3310 M13249 GO_DNA_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEMETHYLATION.html The removal of a methyl group from one or more nucleotides within an DNA molecule. 11/14 Gene Ontology BP GO:0080111 0.00950575344805918 0.0199415107276011 1600 2437.54545454545 2937 0.000867916005602089 231 0.986243430549697 0.986243430549697 1 5.72240754624575 1600 4578 3324 4027 2937 800 231 961 3794 3677 884 3311 M15773 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. 16/22 Gene Ontology BP GO:0055026 0.162607738800145 0.20350021749249 2730 3142.36363636364 2937 0.0160035303774988 1878 1.05257262207382 1.25584217838443 1 2.47759820693031 2730 4541 2445 4354 2437 2937 3003 1878 4358 3506 2377 3312 M16149 GO_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. 731/971 Gene Ontology BP GO:0032386 0.605029720391181 0.650966212433383 2860 3062.90909090909 2937 0.0887103417025071 1308 0.974789959933006 1.01252489019991 1 0.610701387450417 2856 1308 4597 2206 2811 3412 2937 3532 1971 4150 3912 3313 M12452 GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. 73/109 Gene Ontology BP GO:0035050 0.00577426225782821 0.0134540021460564 3795 2359.36363636364 2938 0.000526315789473684 99 1.25324484971865 -1.3111965210073 -1 8.00679359108599 3791 99 1111 159 3895 2938 4312 3899 751 711 4287 3314 M16232 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html The directed movement of a protein to a specific location in the plasma membrane. 116/130 Gene Ontology BP GO:0090002 0.127280113384191 0.164418203102899 2940 2683.45454545455 2938 0.0123001486815679 13 0.923984195364152 -0.925374748541012 -1 2.46619336214069 2938 13 3309 1274 3708 4080 2859 1758 1602 3768 4209 3315 M10755 GO_TRANSITION_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSPORT.html The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 87/122 Gene Ontology BP GO:0000041 0.224286543462046 0.269944461130083 3225 2855.72727272727 2940 0.0228238743430059 926 1.04310730513228 1.22829640158342 1 2.01759978337876 3221 3001 2895 2775 2132 3577 3609 3852 926 2485 2940 3316 M10139 GO_RESPONSE_TO_UV_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_C.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. 12/13 Gene Ontology BP GO:0010225 0.00049855695094425 0.00242655386270251 3045 2739.09090909091 2942 4.53336334709918e-05 293 0.532247235318289 -0.570517320425069 -1 4.74793721420079 3042 1213 3658 2653 293 2382 2380 3503 2942 4444 3620 3317 M10281 GO_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGY.html Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 299/374 Gene Ontology BP GO:0010506 0.68618940391 0.691390059851284 2570 2819.45454545455 2942 0.1 652 0.88783258591104 0.949775776847997 1 0.475850148177733 2569 652 4005 1428 3241 2958 2651 3822 2636 4110 2942 3318 M11352 GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. 12/12 Gene Ontology BP GO:0051103 0.00207923896767789 0.0066860393342123 2220 2878.90909090909 2942 0.000189200607129634 274 1.30745724241497 -1.30745724241497 -1 9.71110948224022 2220 4574 3669 4394 2730 2421 2942 274 3853 3754 837 3319 M11452 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. 18/24 Gene Ontology BP GO:2000725 0.0162684471948142 0.0302183971247386 1965 3010 2943 0.00149000078492268 786 1.25701440385681 1.29933817741907 1 6.52062325069275 1964 3534 2367 2943 4623 4062 3582 786 4128 2642 2479 3320 M12608 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. 21/24 Gene Ontology BP GO:0048009 0.012275696527949 0.0241619356787422 4650 2794.18181818182 2943 0.00112224846614528 405 0.841109978354224 -0.77049201521995 -1 4.638982759036 4648 405 2943 1136 968 3511 4542 3939 1697 2924 4023 3321 M14689 GO_DENDRITIC_SPINE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. 33/39 Gene Ontology BP GO:0097061 0.575380059675214 0.623194464075599 3680 2983.90909090909 2943 0.0749145438832376 1434 1.05395132916067 -1.07113886478406 -1 0.729391480370435 3676 1644 2676 1434 2695 3865 3423 2763 3826 2943 3878 3322 M14931 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. 46/60 Gene Ontology BP GO:0035088 0.373038623754485 0.425950605234262 2895 2920.54545454545 2943 0.0415546729946485 1856 1.13415220575291 -1.04236212209327 -1 1.42653636403307 2892 3047 2249 2813 2607 3731 1856 4054 2970 2964 2943 3323 M15632 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. 46/60 Gene Ontology BP GO:0061245 0.373038623754485 0.425950605234262 2895 2922.72727272727 2944 0.0415546729946485 1857 1.13415220575291 -1.04236212209327 -1 1.42653636403307 2893 3048 2250 2814 2608 3732 1857 4068 2971 2965 2944 3324 M11555 GO_REGULATION_OF_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of tolerance induction. 28/59 Gene Ontology BP GO:0002643 0.45003008718872 0.499520514238815 2565 2894.90909090909 2945 0.0529030276138847 1538 0.997918715611176 -1.03416644733691 -1 1.01782253680931 2563 2234 2707 1538 2517 3288 3946 3253 2945 3388 3465 3325 M12840 GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to another neuron across a synapse. 50/105 Gene Ontology BP GO:0007270 0.0751465470267458 0.10496345506116 4140 3124.72727272727 2947 0.0070766583499667 1193 1.37046382269956 1.69598796502632 1 4.5763059405427 4139 2145 1193 2044 2947 4637 3856 4544 2641 2895 3331 3326 M15340 GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. 230/336 Gene Ontology BP GO:0002218 0.448293696940057 0.497711899752347 4405 2745.27272727273 2947 0.0526315789473684 364 1.01819993677549 -0.978687450314968 -1 1.04420888254604 4403 673 2523 364 2737 3451 4340 3658 1666 2947 3436 3327 M13855 GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION.html The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. 28/34 Gene Ontology BP GO:0043687 0.480333643283724 0.530373147175883 4175 2926 2950 0.0577703163912698 687 0.996297793060943 -0.640785304475327 -1 0.927492377521416 4171 2238 2950 2500 2550 3031 4057 2803 687 3393 3806 3328 M15494 GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 64/90 Gene Ontology BP GO:0046889 0.00577426225782821 0.0134540021460564 3210 2268.81818181818 2950 0.000526315789473684 119 1.16842934806017 1.19835109345458 1 7.46419843850174 3210 119 1433 176 3712 3941 2950 3618 1148 865 3785 3329 M15509 GO_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. 221/300 Gene Ontology BP GO:0030099 0.136090824729801 0.174203743457432 2955 2549.09090909091 2951 0.0132108367378972 322 1.06435285852171 1.05231014534284 1 2.75110359506969 2951 678 1354 322 3829 4059 3111 3774 2291 1033 4638 3330 M16046 GO_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORYLATION.html The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. 1131/1444 Gene Ontology BP GO:0016310 0.552753860361537 0.60176970338377 4235 2959.81818181818 2951 0.0773124511972534 573 0.991503958566936 -0.924947386781513 -1 0.737046394627773 4232 573 4590 1183 4403 2124 3924 3978 1817 2951 2783 3331 M10566 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. 31/40 Gene Ontology BP GO:0051154 0.612747885743433 0.658760608217235 2450 2970.27272727273 2954 0.0826292458306601 2375 1.27860955290761 1.21918438334759 1 0.781769243776029 2446 3441 2375 3627 3032 3291 2954 2778 3288 2770 2671 3332 M12694 GO_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACETYLATION.html The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic 129/148 Gene Ontology BP GO:0006473 0.0172465067781096 0.031631058745977 1580 2816.63636363636 2954 0.00158029185347927 1069 0.827962579926183 0.764962429709091 1 4.23515606612797 1577 3657 4115 4254 1069 1848 1390 2954 3012 4264 2843 3333 M14221 GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is decreased. 24/46 Gene Ontology BP GO:0045776 0.00677637791208726 0.0152100754582451 2955 2811.90909090909 2955 0.000617940070261376 730 1.54570506814499 1.11044637380478 1 9.59619906974488 2589 2772 730 3005 2955 3505 2953 3236 3115 2261 3810 3334 M14517 GO_CELLULAR_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 63/108 Gene Ontology BP GO:0071277 0.00229283719393558 0.00716973888668163 4475 2805.54545454545 2955 0.000208657298032788 588 1.36049410925349 -1.50261356889946 -1 9.96437292201186 4474 3708 588 3922 3350 3115 1985 2783 2955 1494 2487 3335 M14465 GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. 7/18 Gene Ontology BP GO:0033604 0.00216084101772321 0.00686783020981791 3420 2751.54545454545 2957 0.000216294505299191 551 1.66876756154655 -2.1307851143479 -1 12.3312086210867 3418 2422 4496 3013 551 2957 1446 4502 991 2594 3877 3336 M14887 GO_INTERACTION_WITH_SYMBIONT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_SYMBIONT.html An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 52/80 Gene Ontology BP GO:0051702 0.00542244054640605 0.0133778451020293 3265 2698.54545454545 2957 0.00049416834397503 750 1.03601175537715 1.22578844466588 1 6.62580802332444 1771 3045 3265 3821 750 2927 2639 3261 1520 3728 2957 3337 M15232 GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. 1133/1532 Gene Ontology BP GO:0051248 0.260839263727336 0.309850675037859 2775 2977.72727272727 2957 0.0297718099316965 1449 1.08830859748068 -1.0292549937818 -1 1.88269277241584 2773 1882 4543 2522 2240 3456 2957 3795 3026 1449 4112 3338 M14623 GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of monocyte differentiation. 11/19 Gene Ontology BP GO:0045655 0.68618940391 0.691390059851284 4410 3048.45454545455 2959 0.1 1575 0.834955116892766 -0.918019791812706 -1 0.446874448929233 4410 2393 2658 1575 2901 4163 3468 3097 3429 2480 2959 3339 M13305 GO_VACUOLAR_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_ACIDIFICATION.html Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. 16/18 Gene Ontology BP GO:0007035 0.372335845956008 0.425461368181067 4100 2690 2961 0.0414570548097178 211 0.865778347333899 0.992054401002295 1 1.08793005626716 4097 1788 2961 1851 3413 1690 2789 4307 211 2996 3487 3340 M15525 GO_CARDIAC_CHAMBER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_FORMATION.html The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. 12/19 Gene Ontology BP GO:0003207 0.381794341429296 0.433819064876804 2430 2798.45454545455 2962 0.04277928454056 1247 1.4012583966627 1.6577398368214 1 1.72692947881105 2582 3240 2429 3170 4064 2962 2430 3435 1247 3202 2022 3341 M13117 GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 41/45 Gene Ontology BP GO:0010837 0.0993879861661259 0.133079798454959 1800 2829.27272727273 2963 0.00947129220286133 978 1.21930510163084 -1.340171898659 -1 3.64068603001972 1799 4074 2340 4172 1770 1761 978 4592 3632 3041 2963 3342 M12022 GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS.html The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. 8/15 Gene Ontology BP GO:0048703 0.0915723168992247 0.124150929642218 2265 3080.09090909091 2964 0.00955802834806641 986 0.942951819102456 -0.942951819102456 -1 2.91035433941003 2262 2918 4339 3736 2787 1872 986 2970 4550 4497 2964 3343 M14884 GO_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ASSEMBLY.html A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. 179/211 Gene Ontology BP GO:0034329 0.0451995993953021 0.0684392242064239 2490 2762.63636363636 2964 0.00419598713823269 1075 1.1935296298842 1.17490737113669 1 4.74200883564467 2486 2964 1075 2749 3717 4454 3481 1704 3126 1299 3334 3344 M15174 GO_VISUAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VISUAL_BEHAVIOR.html The behavior of an organism in response to a visual stimulus. 51/78 Gene Ontology BP GO:0007632 0.68618940391 0.691390059851284 4595 2866.54545454545 2964 0.1 331 1.4576051767313 -1.34607303811081 -1 0.788073095647878 4593 3373 2530 1420 3339 4133 4083 2964 331 1987 2779 3345 M13048 GO_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEARNING.html Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. 147/227 Gene Ontology BP GO:0007612 0.000918326087007299 0.00373185264877289 3120 2371.09090909091 2965 8.35190581560481e-05 470 1.41182500801487 -1.50339086992624 -1 11.7095495042069 3118 2972 493 815 1782 3938 2965 4483 1211 470 3835 3346 M16313 GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. 11/18 Gene Ontology BP GO:1903209 5.26579645941109e-05 0.000472095393557607 2580 2538.27272727273 2965 4.78720227525621e-06 95 0.7249491524655 -0.585506010070661 -1 8.23296405335826 2579 3245 2965 3296 95 2272 697 3104 4524 3683 1461 3347 M13146 GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that modulates I-kappaB kinase/NF-kappaB signaling. 308/420 Gene Ontology BP GO:0043122 0.68618940391 0.691390059851284 3020 2885.72727272727 2966 0.1 1287 1.03181347712957 1.09164721328083 1 0.554748534937457 2433 2483 2966 1287 3688 3016 3019 3698 2624 2679 3850 3348 M16429 GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. 170/262 Gene Ontology BP GO:0098742 3.03707940501537e-12 2.43647077095458e-10 2970 2619.81818181818 2967 2.76098127729051e-13 40 1.61927905888805 -1.74569629443436 -1 53.2104372911733 4127 2967 40 2966 3790 4555 3819 935 3252 523 1844 3349 M12005 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 84/100 Gene Ontology BP GO:0010595 0.0143908298819172 0.0273867204255873 3735 2852 2970 0.00131689414644685 850 1.18981371372889 -1.03413628027587 -1 6.34528455762713 3731 1494 850 2890 2970 4154 4186 3690 1607 1330 4470 3350 M11278 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY.html Any process that increases the activity of triglyceride lipase. 4/15 Gene Ontology BP GO:0061365 0.0391521571748176 0.0612352898603114 3235 3119 2971 0.00398595637072438 1399 0.575317096277988 0.575317096277988 1 2.37527914728198 3234 2933 4291 2651 1399 2971 3539 1872 4579 4468 2372 3351 M12111 GO_INNER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 36/63 Gene Ontology BP GO:0036159 0.00738050875778157 0.016283313063043 2335 2493.36363636364 2971 0.000673216875842575 617 1.27335525702648 1.2294413145595 1 7.77457701432736 2332 3410 1379 3239 825 4055 3014 617 3191 2394 2971 3352 M11042 GO_POSITIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOR_SIGNALING.html Any process that activates or increases the frequency, rate or extent of TOR signaling. 29/31 Gene Ontology BP GO:0032008 0.233697701077446 0.280184334736757 2695 2973.72727272727 2972 0.0239076236810325 1522 0.925128866126075 1.18218323665512 1 1.73705408409771 2691 2233 3570 2688 2972 3035 1522 4340 3117 4190 2353 3353 M15873 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. 79/96 Gene Ontology BP GO:2001022 0.29766620534484 0.348964689712658 2105 3024.90909090909 2973 0.031611964411602 1771 1.0131468646558 -1.02928691244346 -1 1.57309456712979 3980 2105 2973 2881 3834 2104 3876 3686 3203 2861 1771 3354 M16865 GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. 150/178 Gene Ontology BP GO:0071901 0.281846361995537 0.331923847725952 4515 3010.72727272727 2973 0.0296490143226011 1346 1.18880005667862 1.14811422842917 1 1.93605003860668 4514 2973 2528 3346 2755 3884 4302 4333 1407 1346 1730 3355 M11248 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD.html The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). 34/61 Gene Ontology BP GO:0043153 0.0309106884938784 0.0503597456449636 2355 2521.54545454545 2974 0.0028503393744794 1283 1.04258244560341 1.10890770482586 1 4.61580533489937 2353 3413 3057 3298 1283 2566 1289 3015 3086 2974 1403 3356 M11929 GO_RESPONSE_TO_INTERFERON_ALPHA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_ALPHA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. 26/37 Gene Ontology BP GO:0035455 0.543063372552709 0.592328615210444 4200 2842.54545454545 2974 0.0687252763663938 1184 0.978783121144504 -0.868017328479295 -1 0.750435214954696 4196 2740 2989 2524 3001 2051 2974 3821 1184 2410 3378 3357 M13258 GO_FC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 201/363 Gene Ontology BP GO:0038093 0.275734466938957 0.325137474573483 4280 2789.81818181818 2974 0.0289011540425576 692 0.871558541255526 -0.840885933429152 -1 1.44328617469733 4277 692 3657 867 2227 2321 4187 4155 1821 3510 2974 3358 M13345 GO_REGULATION_OF_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 1517/2098 Gene Ontology BP GO:0080134 0.115834177396861 0.151482975668239 3080 2680 2976 0.0122355940451173 569 1.10570737214319 -1.04171160734253 -1 3.08785323165289 2655 569 4421 1190 3080 3859 2976 3079 2684 1010 3957 3359 M16766 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. 149/198 Gene Ontology BP GO:0032387 0.0403080165065217 0.0625594398948783 2730 2929.36363636364 2976 0.00373327724881396 1374 1.03898333314072 1.11439992461636 1 4.26518111932186 2727 2976 3187 2713 1374 3940 3421 2312 3151 3726 2696 3360 M14484 GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 254/307 Gene Ontology BP GO:0051494 0.225506499600585 0.271202311357333 2980 2900.09090909091 2977 0.0229636828870427 1560 1.05266002660909 -1.12028579060851 -1 2.02890826818617 2977 3966 3498 2988 3886 1722 3552 2655 2315 2782 1560 3361 M10932 GO_T_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 38/50 Gene Ontology BP GO:0043029 0.20144436686907 0.245101320414803 2980 2336.72727272727 2978 0.0202423740219731 303 0.940941952775111 1.00863625874174 1 1.95383125019182 2978 1602 3146 917 3276 3286 1843 2015 303 3212 3126 3362 M13923 GO_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. 25/54 Gene Ontology BP GO:0055078 0.106777377367825 0.141306921755544 2430 2932.45454545455 2978 0.0102128934653484 1282 1.32319505274407 -1.07363112527562 -1 3.83394201201241 2430 3134 1282 4122 3244 4506 2689 3257 2978 2342 2273 3363 M13246 GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 131/165 Gene Ontology BP GO:0072522 0.110126016186026 0.145078242727514 1245 2943 2983 0.0105508017997379 903 0.784089796078866 -0.71527858718233 -1 2.23688178913764 1245 2983 3879 4330 4369 903 1689 2787 3863 4087 2238 3364 M15318 GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY.html Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. 58/75 Gene Ontology BP GO:0034260 0.422009167613185 0.473386850748349 2810 2857.27272727273 2983 0.0486146710400561 1133 1.08346650162275 0.976316204179323 1 1.1924387876094 2810 2133 2983 3279 2470 3005 2161 4023 1133 3255 4178 3365 M16764 GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that modulates the frequency, rate or extent of response to reactive oxygen species. 37/43 Gene Ontology BP GO:1901031 0.0268976571261329 0.0452475772262821 1100 2910.90909090909 2983 0.00247565953490839 975 0.96847472019973 1.12602689563675 1 4.44088175405162 1099 4414 2979 4548 3665 2983 1816 975 4347 3169 2025 3366 M11034 GO_C21_STEROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 25/43 Gene Ontology BP GO:0008207 8.22985763566108e-05 0.000641432622759313 2290 2904.27272727273 2984 7.481968652684e-06 126 1.49109082138485 -1.30121678687909 -1 16.2663569079472 2287 4461 1715 2984 126 2933 4043 4251 4196 3206 1745 3367 M10093 GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 114/171 Gene Ontology BP GO:0008277 0.0164799015520419 0.0304894560324656 4060 2841.45454545455 2985 0.00150951460097996 828 1.26349906595219 -1.33695006068983 -1 6.53756331021918 4060 2562 879 2503 4070 3846 2985 3655 2235 828 3633 3368 M14589 GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that activates or increases the frequency, rate or extent of protein acetylation. 41/48 Gene Ontology BP GO:1901985 0.0559868621278698 0.0821529074364485 640 2469.90909090909 2985 0.00522405199397032 636 0.934955453300962 1.06133648621642 1 3.45881396212952 636 3071 2985 4046 4200 1087 1434 1337 4000 3043 1330 3369 M14726 GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT.html The directed movement of substances from early endosomes to the Golgi. 15/16 Gene Ontology BP GO:0034498 0.00417359582367594 0.0110929214706609 3570 2503 2985 0.000380139509023224 663 0.913065229720098 0.913065229720098 1 6.09216031920643 1842 3567 3568 3397 681 2985 3154 1409 663 3880 2387 3370 M10400 GO_PIGMENT_GRANULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_LOCALIZATION.html Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. 25/29 Gene Ontology BP GO:0051875 0.127648580608618 0.16475696132369 2990 2984 2986 0.0123380661779856 1761 0.898231822342378 -1.04349315705153 -1 2.39441578077661 2986 3471 3668 4504 2653 2123 2300 1761 3453 3558 2347 3371 M15041 GO_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXPLORATION_BEHAVIOR.html The specific behavior of an organism in response to a novel environment or stimulus. 30/41 Gene Ontology BP GO:0035640 0.0167541095351685 0.0308617860915039 4400 2939.18181818182 2987 0.00153482524201895 884 1.78078534101385 -1.7832964509337 -1 9.1863632889973 4397 3443 884 2987 4457 4041 3997 2675 1708 1161 2581 3372 M10905 GO_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSPORT.html The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 413/695 Gene Ontology BP GO:0030001 7.51886296815612e-12 5.38234913705083e-10 3345 2447.90909090909 2988 6.83532997107438e-13 45 1.24334715868232 -1.26331766195993 -1 39.3914059291957 3341 619 45 1700 2988 4184 3240 4322 2172 164 4152 3373 M15689 GO_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTOSIS.html A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells. 318/474 Gene Ontology BP GO:0006887 0.0293972805381612 0.048505512887966 3585 2821.27272727273 2989 0.00270887347006445 1169 1.10366890983526 -1.17783914280667 -1 4.94835463030369 4098 2482 1169 2989 1258 3934 3261 3584 3583 1693 2983 3374 M15971 GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 22/23 Gene Ontology BP GO:0048011 0.00178413300836062 0.0060428429119702 4595 2616.54545454545 2990 0.000162325593705436 486 0.864520729798677 -0.934576434882924 -1 6.54743524125271 4592 3817 3066 2204 492 2164 3226 486 4008 2990 1737 3375 M15508 GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. 29/31 Gene Ontology BP GO:0006760 0.586748345285995 0.634031595591206 4075 2984 2991 0.0771939815319168 972 1.43181654486469 1.38428702528779 1 0.958064845781421 4071 3449 2619 2991 2748 2122 2338 4004 972 3054 4456 3376 M16861 GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION.html A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. 22/22 Gene Ontology BP GO:0042772 0.020298246066522 0.0359938029525635 3590 2969.81818181818 2991 0.00186254388627247 382 1.32206460712152 -1.3648414905155 -1 6.51528799354391 3586 2784 2628 1819 4643 2929 382 3649 3333 2991 3924 3377 M14950 GO_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_LINEAGE_COMMITMENT.html The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. 8/16 Gene Ontology BP GO:0002360 2.43213942906913e-06 3.75971586825869e-05 4425 2451.54545454545 2992 2.43214209095921e-07 11 1.49936613564578 -1.58771625835453 -1 22.6722161729712 4422 547 4527 132 11 2992 4205 4247 418 1309 4157 3378 M12161 GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 5/10 Gene Ontology BP GO:0046133 0.0110897631592414 0.0223961232551867 2630 2700.27272727273 2993 0.00111454972902305 706 1.3586100352197 -1.3586100352197 -1 7.65281114359793 2626 4267 4348 3912 3074 1964 1144 706 2993 3156 1513 3379 M14947 GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. 25/50 Gene Ontology BP GO:0045143 0.197367770253895 0.240784539850911 2350 2949 2993 0.0197887324211588 1462 0.767603823302936 -0.883618841132414 -1 1.61218936460105 2346 2756 3647 3301 3742 2368 2993 2473 3212 4139 1462 3380 M15287 GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 30/42 Gene Ontology BP GO:0071392 0.197657834351653 0.241075203994296 3870 2511.18181818182 2993 0.0198209413098043 286 1.22215245216883 1.18396059164587 1 2.570997370728 3869 286 1850 652 2993 3596 3057 4633 1751 1162 3774 3381 M11459 GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. 22/32 Gene Ontology BP GO:0065005 0.000536372703019934 0.00254480597466169 3860 2804.63636363636 2994 4.87730471304684e-05 308 1.11904014776073 1.10746294590428 1 9.91514521172362 3857 1708 2294 2087 308 4156 2994 3091 3459 2982 3915 3382 M11819 GO_REGULATION_OF_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_BINDING.html Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 25/33 Gene Ontology BP GO:0035561 0.0409321674392203 0.0633477315848848 1480 2672.09090909091 2995 0.00379219811416694 575 0.950100605630218 1.19631254738174 1 3.8817269324992 1480 4152 3768 4074 2096 1401 575 4156 2995 3887 809 3383 M12291 GO_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by the detection of a hormone. 142/264 Gene Ontology BP GO:0009755 0.664373915473696 0.691390059851284 3385 2948.81818181818 2995 0.0944843235285436 1549 1.11572515213371 -1.14803635639256 -1 0.600730301907386 3384 2027 2995 1549 3321 2268 3427 4111 2006 2952 4397 3384 M12295 GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. 98/122 Gene Ontology BP GO:0032091 0.0723716754736287 0.101920522390676 1720 2711.81818181818 2995 0.00680619935057709 880 0.83444408322138 0.95988498664369 1 2.81868787234484 1717 2995 3351 3651 1591 880 1852 3836 3912 4060 1985 3385 M10449 GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any negative regulation of signal transduction that takes place in extracellular region. 9/15 Gene Ontology BP GO:1900116 0.144624516925544 0.183411795381454 3000 2859.18181818182 2996 0.0155000921421467 1202 1.25894767026485 -1.18568466662044 -1 3.15974950373833 2996 3934 4241 3910 4087 1788 1255 2635 1202 2182 3221 3386 M12569 GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. 46/63 Gene Ontology BP GO:0061005 0.0039795524804337 0.0107656149368942 3140 2475.36363636364 2996 0.000362433575091633 650 1.31251663583937 -1.49844562516013 -1 8.8204159826776 3137 3055 650 2996 3899 1889 3877 3013 2304 652 1757 3387 M13528 GO_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neuroblast proliferation. 29/44 Gene Ontology BP GO:1902692 0.00519362928099912 0.0129797740262249 4165 3036 2996 0.00047326643350273 744 1.07221129546128 -0.886910150525776 -1 6.90578676265259 4165 2734 2921 3188 744 3818 3695 2768 2996 2636 3731 3388 M15186 GO_ENDOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_SYSTEM_DEVELOPMENT.html Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. 85/165 Gene Ontology BP GO:0035270 0.192121195350029 0.2354569124404 3435 2648.09090909091 2996 0.0192079688922208 1454 1.09858339020405 -1.0722741950318 -1 2.34843712617279 3432 1493 1454 1652 3791 3555 3302 2996 2034 1877 3543 3389 M15237 GO_MITOCHONDRIAL_GENOME_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_GENOME_MAINTENANCE.html The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. 30/31 Gene Ontology BP GO:0000002 0.0880655531923569 0.120414052014116 3150 2801.90909090909 2996 0.00834563205274352 995 0.774295995833385 -0.676639079255732 -1 2.42303969000617 3150 995 3436 2079 1685 2275 2980 4366 3078 3781 2996 3390 M13296 GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any regulation of signal transduction that takes place in the extracellular region. 9/15 Gene Ontology BP GO:1900115 0.144624516925544 0.183411795381454 3000 2881.18181818182 2997 0.0155000921421467 1203 1.25894767026485 -1.18568466662044 -1 3.15974950373833 2997 3935 4419 3911 4088 1789 1256 2686 1203 2187 3222 3391 M15205 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. 31/41 Gene Ontology BP GO:0035850 0.0306920217928686 0.0500385344787027 3705 2564.54545454545 2998 0.00282988708312285 690 1.35635554137202 -1.57222452441233 -1 6.02106282662171 3702 3111 1015 2998 2471 3053 3577 3869 2099 690 1625 3392 M16841 GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 20/24 Gene Ontology BP GO:0060260 0.0128403350981378 0.0250507669650462 3890 2768.63636363636 2999 0.00117417236930045 350 1.40912060314988 -1.17515176559093 -1 7.70335192620091 3887 3166 3388 2924 986 2770 2905 3376 350 3704 2999 3393 M14283 GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. 16/40 Gene Ontology BP GO:0042537 0.00867605649443931 0.0184673791713752 2030 2782 3000 0.000791860185181696 594 1.31553146520316 -1.5393447422651 -1 7.78658325983803 3187 4191 2027 4313 1928 1850 3464 594 4022 3000 2026 3394 M16185 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 9/23 Gene Ontology BP GO:0032700 0.0046273346013046 0.0119021491983805 4620 2513.45454545455 3000 0.000463699843609917 201 1.16514198349803 -1.35895554534197 -1 7.65519731669622 4616 532 4601 201 740 3000 4177 4253 378 1471 3679 3395 M15713 GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-2 production. 50/66 Gene Ontology BP GO:0032663 0.68618940391 0.691390059851284 3865 2790.54545454545 3001 0.1 1107 1.134811363242 1.14467978036033 1 0.611189129138246 3862 1566 2237 1107 4236 3001 3293 3377 1266 2269 4482 3396 M14356 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING.html Any cell surface receptor signaling pathway that is involved in cell-cell signaling. 45/99 Gene Ontology BP GO:1905114 0.43119990772354 0.48137552078638 3570 2684.18181818182 3002 0.05 210 1.05355649390698 1.16848983426985 1 1.1330471044368 3568 210 1764 872 3002 4444 3607 2812 1641 3249 4357 3397 M15350 GO_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_CAPPING.html Any process that modulates the frequency, rate or extent of telomere capping. 25/26 Gene Ontology BP GO:1904353 0.134155658082764 0.172152861847518 3940 2897.72727272727 3002 0.0130100938434915 72 1.15436737946589 -0.827739879189004 -1 3.00497080288272 3938 2751 3173 2640 1873 3002 4233 4020 72 3566 2607 3398 M15469 GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of skeletal muscle contraction. 17/25 Gene Ontology BP GO:0014819 0.00136433215988201 0.00497510778991455 4605 2775.81818181818 3002 0.000124107180647883 447 0.893897643139065 -0.994028191258802 -1 7.02834415841027 4602 1774 2405 3002 447 1917 3008 4252 3041 2559 3527 3399 M16876 GO_CYTOSOLIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_TRANSPORT.html The directed movement of substances or organelles within the cytosol. 231/284 Gene Ontology BP GO:0016482 0.0318112611712772 0.051412920538365 4495 2700.90909090909 3002 0.00293461580694413 620 0.997747523825988 -1.07628252475144 -1 4.38618717559848 4491 1963 4003 1509 1298 3433 4392 3002 620 3949 1050 3400 M11986 GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 34/36 Gene Ontology BP GO:0051973 0.00835661149205722 0.0179516681775357 3360 2587 3003 0.000762593052508338 182 1.12593108580725 -0.914545288455925 -1 6.710159283093 3357 1639 3310 1681 864 3003 4175 4275 182 3346 2625 3401 M10314 GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 17/18 Gene Ontology BP GO:0043517 0.110329375946631 0.145305006023117 3045 3134.18181818182 3004 0.0105713598746636 1669 1.37923988794542 -1.36614259903125 -1 3.93964391915325 3041 4538 2439 4525 4240 2377 3004 1669 3930 2551 2162 3402 M11014 GO_ENDOSOME_TO_LYSOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_TO_LYSOSOME_TRANSPORT.html The directed movement of substances from endosomes to lysosomes. 50/55 Gene Ontology BP GO:0008333 0.103497593927366 0.137631981864543 3260 2694.18181818182 3004 0.00988304778562575 190 0.78391323007043 -0.80673920570749 -1 2.29770552440279 3259 190 3934 2571 1762 3157 4291 3004 1009 4071 2388 3403 M15391 GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 22/39 Gene Ontology BP GO:0032891 0.251637968652161 0.299839044337646 2740 2818.36363636364 3004 0.026007498906372 1061 0.99947385002977 -0.892278568650535 -1 1.77688801845887 2739 1061 1540 3481 3004 3353 1719 4161 3755 2063 4126 3404 M10194 GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-beta production. 62/97 Gene Ontology BP GO:0032648 0.0613091625399572 0.088566138869426 2100 2971.18181818182 3005 0.00573522684751448 904 0.829745901912192 0.938711132160055 1 2.97578883382831 2097 4361 3644 4593 3005 1869 904 1376 4032 4107 2695 3405 M15133 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of natural killer cell activation. 16/23 Gene Ontology BP GO:0032816 0.0182664618550652 0.0330461111727634 2865 2917.09090909091 3005 0.00167453762502294 1093 1.08810995012676 1.119164341089 1 5.49849187690856 2864 3875 2583 3952 1093 3218 2510 1482 4025 3005 3481 3406 M15946 GO_RESPONSE_TO_ETHER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. 11/17 Gene Ontology BP GO:0045472 0.0694053612720294 0.0983982772695774 1000 2883 3005 0.00651789311590964 817 0.85487561917495 0.954717867643668 1 2.93260799548073 997 3919 2904 4035 3662 2201 817 3005 4560 3104 2509 3407 M12237 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. 64/95 Gene Ontology BP GO:0032024 0.104040364011385 0.138235240932317 2425 2920.81818181818 3006 0.00993755798868387 1633 1.09780697643919 -1.05444689962541 -1 3.21489087924827 2421 3348 2448 3058 3006 4107 2877 1633 3250 2716 3265 3408 M13928 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 24/28 Gene Ontology BP GO:0010592 0.00497583402316329 0.0125488106828069 4435 2599 3006 0.000453374894943879 352 1.27368100972758 -1.2456762469255 -1 8.26925446118597 4431 3489 3006 1675 732 3898 3978 1596 352 2260 3172 3409 M15642 GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that modulates the frequency, rate or extent of response to oxidative stress. 71/89 Gene Ontology BP GO:1902882 0.0266771798466806 0.04489291783964 535 2399.63636363636 3007 0.00245511523165208 533 0.921348986980562 0.985768635592087 1 4.23503599599656 533 3694 3007 4188 3161 1127 909 973 4175 3269 1360 3410 M12910 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. 67/120 Gene Ontology BP GO:0002708 0.241743088782895 0.289010943501236 2995 3097.81818181818 3008 0.0248437330863191 2109 1.01375347583062 1.07810658174498 1 1.85779205690659 2995 4029 3008 4032 2335 2858 2369 2109 3477 3113 3751 3411 M13756 GO_VESICLE_COATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COATING.html A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. 102/116 Gene Ontology BP GO:0006901 0.000113642227169296 0.000828804518838144 3330 2665.81818181818 3010 1.03316452587718e-05 146 0.985852925371431 -0.856073032740771 -1 10.3759387229649 3330 786 2977 1097 146 3010 3496 4244 2608 4014 3616 3412 M15717 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. 95/166 Gene Ontology BP GO:0045638 0.101780476926286 0.135853287188183 3015 2878.81818181818 3011 0.00971079572229507 1266 1.1494576856394 1.11159069657879 1 3.3963155165498 3011 2076 1266 2559 3670 4144 3359 2417 3028 1852 4285 3413 M10417 GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 43/54 Gene Ontology BP GO:0000271 0.68618940391 0.691390059851284 2800 2628.81818181818 3012 0.1 928 1.12404070073058 -1.12960397922445 -1 0.605287041095224 2798 928 3107 1516 3561 3187 3012 3112 1594 2816 3286 3414 M12853 GO_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_GROWTH.html Any process that modulates the frequency, rate or extent of growth of an organ of an organism. 77/110 Gene Ontology BP GO:0046620 0.68618940391 0.691390059851284 2905 3060.36363636364 3012 0.1 2397 1.04011673271061 1.10880369368403 1 0.559298537820851 2901 3012 2397 2714 3985 3100 3357 3411 2731 2518 3538 3415 M14289 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleoside across a membrane. 10/13 Gene Ontology BP GO:1901642 0.7424502122956 0.746945046013282 2285 3274.63636363636 3014 0.116021042764433 2281 1.42500201843508 1.64590277129626 1 0.606675831356832 2281 2414 2873 4127 4596 2753 2763 3014 4453 3623 3124 3416 M16914 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. 19/23 Gene Ontology BP GO:2000651 0.491004983882197 0.540872677557733 3575 2771.18181818182 3014 0.0595459227538081 317 0.827741373008161 1.07530448023343 1 0.744679411445893 3572 1076 3014 861 2570 4446 4433 3604 317 2737 3853 3417 M10602 GO_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_UPTAKE.html The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. 13/22 Gene Ontology BP GO:0001504 0.0475225827882323 0.071445785207666 4475 2928.54545454545 3015 0.00441648046942467 1249 1.51464200480735 -1.51464200480735 -1 5.92399795733197 4472 2375 1521 3015 1825 4125 4368 1249 3213 3275 2776 3418 M12659 GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. 24/31 Gene Ontology BP GO:0052312 0.0662583677706094 0.0943679783399588 1935 2815.81818181818 3015 0.0062129379350798 1002 0.628779555101035 0.63433347530324 1 2.19322254059216 1934 2775 3547 3419 1552 1704 1002 3657 4243 4126 3015 3419 M14179 GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION.html The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. 8/21 Gene Ontology BP GO:0043046 0.358408198658563 0.411060721803868 3020 3260.18181818182 3015 0.0434099030172662 2412 0.812032280335386 0.812032280335386 1 1.06124840569212 3018 2421 4478 2432 2412 2714 3623 4359 3015 4569 2821 3420 M11402 GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. 10/17 Gene Ontology BP GO:0045835 0.0234153753438183 0.0403077104975163 3020 2596.45454545455 3016 0.00215167012522522 1180 1.00821136934485 -0.788076940149202 -1 4.79659452980062 3630 1242 3018 2407 1180 2128 3639 3064 1324 3016 3913 3421 M16274 GO_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 51/68 Gene Ontology BP GO:0051489 0.0202208455814527 0.0358841266815104 4025 2971 3016 0.00185537532718164 891 1.03221790008811 -0.995538790825893 -1 5.08922937156233 4023 891 2171 1522 1129 4516 4445 4554 3016 2623 3791 3422 M15390 GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 12/22 Gene Ontology BP GO:0046135 0.00580912966677604 0.0135014387310234 2275 2792.63636363636 3017 0.000529502336085574 484 0.976200431368446 -0.976200431368446 -1 6.22933950571344 2274 4232 3017 3936 3345 1627 1882 484 3931 3761 2230 3423 M16658 GO_LOCOMOTORY_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_EXPLORATION_BEHAVIOR.html The specific movement from place to place of an organism in response to a novel environment. 18/24 Gene Ontology BP GO:0035641 0.0404317225241442 0.0626987542743596 3020 2674.63636363636 3017 0.00374495252991392 581 1.63091582237346 -1.65305389807461 -1 6.69584006715553 4038 3522 1147 3017 2199 2768 3852 4085 3020 1192 581 3424 M12757 GO_PHAGOSOME_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_MATURATION.html A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. 41/49 Gene Ontology BP GO:0090382 0.68618940391 0.691390059851284 4570 3218.36363636364 3018 0.1 1086 1.07537298384053 -1.03371447425962 -1 0.578618194157224 4567 2672 2974 2549 4422 3712 4500 3018 1086 3040 2862 3425 M13346 GO_CARDIAC_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_FATE_COMMITMENT.html The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. 7/19 Gene Ontology BP GO:0060911 4.0604559460506e-05 0.000380146911810331 3820 2822.63636363636 3018 4.06053014081982e-06 12 1.66806132166284 -2.39562289322686 -1 19.4939215439832 3816 3946 4422 3018 1538 2156 2317 12 4096 3405 2323 3426 M10998 GO_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. 109/161 Gene Ontology BP GO:0002573 0.0555607676568166 0.0817080442184474 2335 2481.36363636364 3020 0.00518324154566553 35 1.17331247978586 1.21925650009371 1 4.35278002823455 2335 35 1113 414 3943 4006 3020 3996 3123 1531 3779 3427 M13329 GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. 69/119 Gene Ontology BP GO:0002762 0.00728143217822311 0.0161412596118495 2060 2680.45454545455 3020 0.000664149463931938 548 1.24951694735187 1.25339655362962 1 7.64508718519013 2060 3697 1683 3569 2545 3984 3202 548 3052 2125 3020 3428 M13895 GO_SPERMATID_NUCLEUS_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_NUCLEUS_DIFFERENTIATION.html The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. 26/134 Gene Ontology BP GO:0007289 0.00128825898046604 0.00478775482117292 2850 2614.45454545455 3020 0.000117183088018729 433 0.845167604184326 0.854416504405895 1 6.6927899962138 2849 3129 3252 3338 433 2838 1661 3020 1413 3259 3567 3429 M15316 GO_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_LOCALIZATION.html A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. 70/79 Gene Ontology BP GO:0031503 0.00220125795947734 0.00695346455223901 440 2010.90909090909 3022 0.000200314869668167 37 0.96347864165553 -0.994817924348796 -1 7.09730498214689 439 3022 3504 3104 3606 37 491 396 3428 3984 109 3430 M10720 GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 62/91 Gene Ontology BP GO:0048168 0.0896601242807387 0.122232480868365 1465 2509.81818181818 3023 0.00850339075786977 932 1.34191911818382 1.22026290275658 1 4.17728016105377 1461 3713 1536 3179 3723 1768 932 3279 3023 1731 3263 3431 M16430 GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. 68/80 Gene Ontology BP GO:0043525 0.0858769280134881 0.117732865659034 1790 2768.81818181818 3023 0.00812950849558695 913 0.983686900463108 1.09263245905646 1 3.11406968138784 1789 3023 3245 3445 4339 1811 913 2758 3198 3136 2800 3432 M16258 GO_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progress through the mitotic cell cycle. 564/683 Gene Ontology BP GO:0007346 0.379540535774126 0.432208055055557 3265 3285.90909090909 3024 0.0466083557473358 2091 0.907732848369363 -0.877607835921063 -1 1.11996114773191 3262 2453 4608 2958 4586 2228 4084 3024 2512 4339 2091 3433 M12450 GO_CELL_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. 239/292 Gene Ontology BP GO:0034330 0.000649553588686906 0.00294865643722944 2695 2880.63636363636 3025 5.90677681594933e-05 466 1.23287456385391 1.17787273900965 1 10.6552085729334 2695 2503 466 2747 4396 4252 3225 3185 3025 972 4221 3434 M13514 GO_REGULATION_OF_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of ion homeostasis. 188/303 Gene Ontology BP GO:2000021 7.67905418699298e-08 1.96200268681417e-06 3025 2614.63636363636 3025 6.98095859548072e-09 136 1.19937333219615 -1.19653715833875 -1 23.3926608365111 3025 1400 136 2756 2656 4069 3892 3723 3251 512 3341 3435 M16863 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. 10/15 Gene Ontology BP GO:0043568 0.00291355236041795 0.00855805079973809 1385 2806.36363636364 3025 0.000265219824486895 582 1.40295852195094 1.50785694116744 1 9.90699353594101 1381 4590 2356 3940 582 2673 1872 3259 4154 3025 3038 3436 M11907 GO_HISTONE_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEUBIQUITINATION.html The modification of histones by removal of ubiquitin groups. 23/27 Gene Ontology BP GO:0016578 0.00274744501998239 0.00818953342599492 3030 3041.54545454545 3026 0.000250080195125955 571 0.691488009218074 0.754213945329548 1 4.92272882156067 3026 4156 3902 2944 571 2923 2680 3225 1918 4112 4000 3437 M14499 GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 142/172 Gene Ontology BP GO:0044262 0.00577426225782821 0.0134540021460564 3090 2512.27272727273 3026 0.000526315789473684 103 1.05608381305294 1.08191671361469 1 6.74548379887296 3086 743 3003 103 3026 4299 3601 3540 563 2031 3640 3438 M11340 GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. 21/29 Gene Ontology BP GO:0095500 0.010353506053352 0.0212411215459642 4120 2871.54545454545 3027 0.00094568677815822 649 0.920676758901453 -0.756237698711087 -1 5.25495675846054 4116 2286 3125 3027 1876 3542 4377 649 1904 3739 2946 3439 M16557 GO_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PROCESS.html The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 35/73 Gene Ontology BP GO:0050886 0.0930059045674918 0.12583788134706 2850 2882 3027 0.00883522333731512 1244 1.37181920066905 -1.36046554946715 -1 4.21138173878262 2848 3761 1244 3231 2505 4121 2371 3150 3526 1918 3027 3440 M11878 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION.html Any signal transduction that is involved in cellular response to ammonium ion. 21/29 Gene Ontology BP GO:1903831 0.00878565346244582 0.0186324729082773 4120 2867.81818181818 3028 0.000801903291201595 597 0.920676758901453 -0.756237698711087 -1 5.43408533443858 4117 2287 3126 3028 1877 3543 4378 597 1905 3741 2947 3441 M11889 GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. 468/638 Gene Ontology BP GO:0060627 0.00577426225782821 0.0134540021460564 3720 2650.18181818182 3029 0.000526315789473684 93 1.1112246971464 1.06574956164507 1 7.09823979079997 3718 1336 1530 93 3029 4064 3347 4590 1814 1462 4169 3442 M12189 GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 21/29 Gene Ontology BP GO:1905145 0.0263716030109687 0.0445236098730179 4120 2902.63636363636 3029 0.00242664825690057 969 0.920676758901453 -0.756237698711087 -1 4.24323070543968 4118 2288 3127 3029 1878 3544 4379 969 1906 3743 2948 3443 M13242 GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. 21/29 Gene Ontology BP GO:0007213 0.0176256578254151 0.0321490340500417 4120 2889.72727272727 3030 0.001615315736697 817 0.920676758901453 -0.756237698711087 -1 4.68839253970372 4119 2289 3128 3030 1879 3545 4380 817 1907 3744 2949 3444 M13786 GO_REGULATION_OF_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. 26/38 Gene Ontology BP GO:0030823 0.00511485828712293 0.0128280891379529 3885 2479.72727272727 3031 0.000466071714017523 329 1.29324800432962 1.2141243801134 1 8.35418780226935 3883 329 692 569 2255 3212 4042 4450 3031 1177 3637 3445 M14251 GO_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 21/29 Gene Ontology BP GO:1905144 0.0195369400561089 0.0348831090103894 4120 2894.54545454545 3031 0.00179205677878759 858 0.920676758901453 -0.756237698711087 -1 4.57681360132818 4120 2290 3129 3031 1880 3546 4381 858 1908 3747 2950 3446 M15644 GO_GTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GTP, guanosine triphosphate. 25/28 Gene Ontology BP GO:0046039 0.329125738841296 0.381900763797643 2880 3087.54545454545 3031 0.0356379694663669 2252 0.949583299690091 -0.742792171978144 -1 1.34656637167541 2876 2252 2878 3688 2409 3854 3031 2296 3576 3209 3894 3447 M15706 GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION.html Signal transduction in which the initial step occurs in a postsynapse. 21/29 Gene Ontology BP GO:0098926 0.0200280406237643 0.0355960553943373 4125 2896.45454545455 3032 0.00183752065234118 868 0.920676758901453 -0.756237698711087 -1 4.5491553421305 4121 2291 3130 3032 1881 3547 4382 868 1909 3749 2951 3448 M16271 GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 20/27 Gene Ontology BP GO:0042454 0.00185888757223179 0.00622259271481621 1445 2461.36363636364 3033 0.000169132736157676 256 1.2656524430684 -1.2656524430684 -1 9.5352623516074 1442 4175 3033 3939 3174 1435 1381 256 3733 3331 1176 3449 M10453 GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. 68/140 Gene Ontology BP GO:0046634 0.59925595405447 0.645598044504619 2235 3254.63636363636 3034 0.079768686819086 2143 1.13351733673136 -1.17562898267355 -1 0.725816595340758 2233 4357 3000 4412 2909 2143 3034 3567 4005 3135 3006 3450 M12230 GO_NEGATIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WOUND_HEALING.html Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 59/82 Gene Ontology BP GO:0061045 2.4275673062974e-09 9.41289223016815e-08 3030 2466.27272727273 3035 2.20687937179643e-10 89 1.88938918985726 -2.43923447742485 -1 45.377134385365 3030 3035 89 3463 326 3514 2236 3341 3401 143 4551 3451 M12462 GO_PROTEIN_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DESTABILIZATION.html Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. 42/51 Gene Ontology BP GO:0031648 0.00393519333488634 0.0106704280811341 3605 2287.18181818182 3035 0.000358386362573702 209 0.918466029323268 1.05526140475839 1 6.18121505701719 3601 209 3283 591 662 4533 4391 1065 704 3085 3035 3452 M13248 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 35/47 Gene Ontology BP GO:0071157 0.233469032224637 0.279982321376607 1130 2873.72727272727 3039 0.0238811480560937 1127 0.879208438122631 0.906331913866794 1 1.65124461898081 1127 3419 3683 3093 3787 2707 1736 2097 3039 3934 2989 3453 M15376 GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT.html The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis. 30/38 Gene Ontology BP GO:0090662 0.320397812597778 0.372889200104417 3430 3115 3040 0.0345041009331419 1155 1.10343060258037 -1.10507595207033 -1 1.60558293859431 3428 4114 2890 4512 4178 2344 2856 2277 1155 3471 3040 3454 M15645 GO_PROTEIN_K48_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. 52/61 Gene Ontology BP GO:0070936 0.68618940391 0.691390059851284 2105 2986.54545454545 3040 0.1 816 0.898687128198123 0.779083416657448 1 0.481798200507582 2103 3040 3987 2202 4421 2979 3188 2932 816 3729 3455 3455 M10418 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 57/100 Gene Ontology BP GO:0042509 0.204756090749709 0.24849506788169 3585 2655.18181818182 3041 0.0206124534762723 150 1.10434103779352 -1.01306046088492 -1 2.27242621083563 3581 150 1477 671 3041 4612 3813 3727 2089 1426 4620 3456 M13757 GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR.html The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. 19/22 Gene Ontology BP GO:0042994 0.0508633775200632 0.0757093076138369 2600 3044.63636363636 3044 0.0047344412198923 1462 0.896856768852173 -0.702719053481491 -1 3.42620868170141 2599 4176 3583 4196 1462 3044 2718 2247 1973 3649 3844 3457 M14294 GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. 67/211 Gene Ontology BP GO:0050830 0.000135966794848507 0.000955669934184448 3970 2702.27272727273 3044 1.23613817039565e-05 368 1.58745631294787 -1.68528645693646 -1 16.3785034362395 3970 2614 368 3492 576 3962 4124 4642 2279 654 3044 3458 M14746 GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. 35/50 Gene Ontology BP GO:0046426 0.246188090263285 0.294022891169165 3050 3056.72727272727 3047 0.0253648042882367 1633 1.22413566486809 -1.26567917659317 -1 2.21429796588568 3047 4418 1804 4314 4102 2681 3047 2378 3910 2290 1633 3459 M15099 GO_NEGATIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STAT_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of STAT cascade. 35/50 Gene Ontology BP GO:1904893 0.246188090263285 0.294022891169165 3050 3050 3048 0.0253648042882367 1634 1.22413566486809 -1.26567917659317 -1 2.21429796588568 3048 4419 1805 4315 4103 2682 3048 2294 3911 2291 1634 3460 M15895 GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. 23/31 Gene Ontology BP GO:0050849 0.0192729866205357 0.0345310769138823 3850 2986.63636363636 3048 0.00176762971418438 1039 0.82460452357163 -0.755572833810663 -1 4.11053146294244 3849 1039 2480 2534 1111 4565 4013 3048 4214 2611 3389 3461 M10883 GO_ASSOCIATIVE_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASSOCIATIVE_LEARNING.html Learning by associating a stimulus (the cause) with a particular outcome (the effect). 70/113 Gene Ontology BP GO:0008306 0.117654646249155 0.153690923356911 3050 2636.72727272727 3049 0.011314750503349 1242 1.42585740989666 -1.39044200683414 -1 3.95437144276977 3049 3349 1945 3396 4177 3302 3190 1707 2037 1610 1242 3462 M12444 GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 658/835 Gene Ontology BP GO:0031344 5.84902136080721e-05 0.000503059083028391 2320 2518.72727272727 3049 5.84917531623928e-06 79 1.19348155628159 1.26142778564923 1 13.4482181513507 2320 1899 4369 79 3285 3183 3049 3925 1765 206 3626 3463 M12471 GO_LAGGING_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAGGING_STRAND_ELONGATION.html The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. 11/11 Gene Ontology BP GO:0006273 0.0576812380310823 0.0841086808394315 3050 3052.54545454545 3050 0.0053865016879692 1510 0.761059220358381 -0.748385663318598 -1 2.7869244846376 3050 4233 3322 4310 1510 2166 2193 3716 2638 3675 2765 3464 M12782 GO_PHOSPHOLIPID_SCRAMBLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_SCRAMBLING.html The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). 15/21 Gene Ontology BP GO:0017121 0.0141465271681421 0.0270101727178356 3570 2773.36363636364 3050 0.00129439274087187 753 1.19271340476968 -0.816284699088219 -1 6.3852932158879 3566 1164 1814 2023 3200 4505 3050 753 4104 2368 3960 3465 M14790 GO_PEPTIDYL_PROLINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_MODIFICATION.html The modification of peptidyl-proline. 47/55 Gene Ontology BP GO:0018208 0.68618940391 0.691390059851284 3480 2990.63636363636 3052 0.1 911 1.09177441485678 -0.957766312240708 -1 0.587605820478891 3480 2170 3269 3052 3011 2773 2861 4171 911 3570 3629 3466 M15861 GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an androgen binding to its receptor. 48/55 Gene Ontology BP GO:0030521 0.265475480239442 0.3146351017713 1765 2834.36363636364 3053 0.0276586515476247 1688 0.858796105129942 1.01674592560521 1 1.46386514446537 1762 3053 3866 3782 3059 2148 2127 3634 1812 4247 1688 3467 M11304 GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 70/82 Gene Ontology BP GO:0033143 0.00148603295007548 0.00529036826067421 3055 2417.45454545455 3054 0.00013518524275387 103 0.823179763764974 -0.65609025512088 -1 6.39637742426676 3054 103 3429 897 462 3461 3747 3191 1770 3637 2841 3468 M12036 GO_ASYMMETRIC_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_CELL_DIVISION.html The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. 18/19 Gene Ontology BP GO:0008356 0.00177278982904877 0.00602101538289338 2975 2796.36363636364 3054 0.000161292725527262 430 1.10008999282527 0.961438356691818 1 8.34033198900951 2975 3848 3054 3724 490 2817 1825 3553 430 3593 4451 3469 M14065 GO_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 266/418 Gene Ontology BP GO:0008544 1.58467243656841e-12 1.44578055830447e-10 4595 2717.54545454545 3054 1.44061130597232e-13 34 1.41536092963163 -1.67324124911714 -1 47.6050401513689 4591 1951 34 2769 3520 3891 3646 3054 3482 161 2794 3470 M16928 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. 1656/2274 Gene Ontology BP GO:0006357 0.197143079366366 0.240636607631611 1215 3006.09090909091 3055 0.0217185568790516 1213 1.03234790443445 1.02225961070704 1 2.17284785872514 1213 4273 4651 4501 3306 1560 1465 2159 3055 4169 2715 3471 M16074 GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. 205/259 Gene Ontology BP GO:0030178 0.68618940391 0.691390059851284 3770 2935 3056 0.1 1276 1.04787461643154 -0.969656216613985 -1 0.563549688824784 3766 1387 2065 1276 4207 3056 4561 4100 1338 2110 4419 3472 M16840 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. 53/108 Gene Ontology BP GO:0046635 0.381304714175286 0.433819064876804 1880 3047.90909090909 3056 0.0427103882700365 1870 1.09131915162768 -1.04833151632811 -1 1.34259778045399 1878 4052 3056 4082 2402 1870 2749 3245 4263 3339 2591 3473 M16873 GO_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_FUSION.html A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 25/49 Gene Ontology BP GO:0007520 0.00147263943611224 0.00525474792655695 3725 2639.36363636364 3056 0.000133966010779619 220 1.26411967154537 -1.63144589137308 -1 9.84101772896172 3721 3801 1047 2847 3056 3068 4062 220 4327 2346 538 3474 M10793 GO_POSITIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BINDING.html Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 181/216 Gene Ontology BP GO:0051099 0.344574680558063 0.39687624907895 1785 2808.72727272727 3057 0.0376782708983402 1785 1.06019443098915 1.10504496333435 1 1.44411174327419 1785 3295 3240 3433 2639 3151 1947 2846 3582 3057 1921 3475 M10111 GO_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSPORT.html The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 894/1474 Gene Ontology BP GO:0006811 3.10713697501026e-11 1.9804805951675e-09 4460 2523.27272727273 3058 3.1071369750537e-12 27 1.21460419435994 -1.1775645091961 -1 36.1309580408624 4456 578 4225 241 3267 1767 4275 4210 1652 27 3058 3476 M11876 GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 24/42 Gene Ontology BP GO:0060079 0.0264970226434703 0.0446705240435026 4360 2836.90909090909 3059 0.00243833113584172 971 1.30821433664679 -1.07573659447827 -1 6.02740969806792 4360 3136 1886 1835 2562 4295 4596 971 1382 3124 3059 3477 M13702 GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. 34/36 Gene Ontology BP GO:0000959 0.0557173375558011 0.0818348395350829 2745 2921.36363636364 3059 0.00519823554156767 609 0.831927301452831 -0.938979530922332 -1 3.08128407389758 2745 4428 3978 4377 2569 609 749 3059 3907 4105 1609 3478 M10731 GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA processing. 46/61 Gene Ontology BP GO:0050685 0.0126859264370471 0.0248015192065462 1820 2651.90909090909 3060 0.0011599703382411 614 0.699901554174274 0.681945884906514 1 3.83123286120997 1817 3377 3709 3792 979 614 1089 3060 4503 4234 1997 3479 M14562 GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 23/34 Gene Ontology BP GO:0045663 0.117796345570272 0.153832836356575 4000 3212.18181818182 3060 0.0113291858175247 1815 0.953359408477708 -0.907828533277592 -1 2.63913922930362 4000 2765 2784 2802 1815 4514 2027 3708 3469 3060 4390 3480 M15397 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein. 40/68 Gene Ontology BP GO:0042516 0.43119990772354 0.48137552078638 4065 2935.81818181818 3060 0.05 238 1.09228723880773 -0.978653029478522 -1 1.17509205821978 4062 238 1828 1659 2798 4027 3937 4557 3060 1925 4203 3481 M16037 GO_INACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INACTIVATION_OF_MAPK_ACTIVITY.html Any process that terminates the activity of the active enzyme MAP kinase. 26/28 Gene Ontology BP GO:0000188 0.205225061567483 0.248869484355877 4525 2942 3061 0.0206649733656195 1180 1.26651958832673 -1.4353009460915 -1 2.60487898553965 4521 2257 2125 2063 3727 3948 3571 3061 1509 1180 4400 3482 M13263 GO_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 20/21 Gene Ontology BP GO:0090140 0.0277978374862612 0.0464929323593002 3500 3015.27272727273 3062 0.00255958321396479 987 1.09841883623975 -1.28154509221132 -1 4.99388060010717 3498 3518 2809 3062 2532 2696 3865 987 4141 3326 2734 3483 M15162 GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organonitrogen compound. 969/1252 Gene Ontology BP GO:1901566 0.462549296200039 0.511829221217309 2950 3216.63636363636 3062 0.0602034127753109 1959 1.03188864995501 -0.979976480080425 -1 1.01553613778419 2949 4275 4538 3458 3099 1959 3039 2716 2128 4160 3062 3484 M15824 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. 27/35 Gene Ontology BP GO:2000352 0.68618940391 0.691390059851284 1830 3234.90909090909 3062 0.1 1830 1.38833110126662 1.14112093806485 1 0.75011241383671 1830 4493 2239 4595 3062 2863 2537 3565 4233 2937 3230 3485 M11828 GO_PROTEIN_LOCALIZATION_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_LYSOSOME.html A process in which a protein is transported to, or maintained in, a location within a lysosome. 29/30 Gene Ontology BP GO:0061462 0.00957814574169789 0.0200270475881494 2360 2903.27272727273 3063 0.0008745547359363 896 0.836108556547043 0.823278332782212 1 4.84435406153772 2359 2718 3378 1416 896 3063 3335 4064 4508 3723 2476 3486 M14071 GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 72/90 Gene Ontology BP GO:0071479 0.68618940391 0.691390059851284 4495 3348.81818181818 3063 0.1 2065 1.09410620493331 -0.906223245791755 -1 0.588883590561734 4493 2604 2866 3533 3028 3630 3038 4447 2065 3063 4070 3487 M10641 GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. 48/66 Gene Ontology BP GO:2000351 0.0564081538206175 0.0826668156621521 2225 3019.63636363636 3064 0.0052644189091747 1119 1.51533641349643 1.38578974433169 1 5.59848778411619 2225 4392 1119 4264 1841 3958 3064 2400 4199 2119 3635 3488 M12963 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. 59/66 Gene Ontology BP GO:0042274 0.0279872322327938 0.0467760745614905 950 3081.27272727273 3064 0.00257724945218143 948 0.482808851611336 0.494384564779903 1 2.18472643944172 948 4375 4168 4636 1236 2394 1662 2332 4551 4528 3064 3489 M10050 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. 47/50 Gene Ontology BP GO:0048008 0.0978807362092201 0.131477790294891 1425 2677.54545454545 3066 0.00932070371396325 1353 0.987909276449046 1.05777473391797 1 2.96551007407732 1424 3735 3098 3994 1730 1605 1353 3066 3305 3036 3107 3490 M10463 GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. 18/22 Gene Ontology BP GO:0033599 0.000489645586438365 0.00240075965616197 3330 2486.90909090909 3066 4.45231453593613e-05 107 0.897094467248747 -1.01267330801337 -1 8.02411900943175 3326 2816 3166 3066 645 4428 3523 107 1959 3138 1182 3491 M14231 GO_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/57 Gene Ontology BP GO:0032371 0.0159615755036272 0.0297195721562134 4345 3106.63636363636 3068 0.00146168827405751 1052 1.1321903156722 1.09138933279434 1 5.90003549325114 4343 3068 1635 3965 1052 2746 3845 2998 4160 2970 3391 3492 M10076 GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that activates or increases the frequency, rate or extent of protein maturation. 21/42 Gene Ontology BP GO:1903319 0.0196010710818346 0.0349573720750388 4590 2819.45454545455 3069 0.00179799256429588 777 1.40022362111142 -1.12553328928427 -1 6.96184079676877 4547 2277 902 1482 3311 3069 4588 3442 2029 777 4590 3493 M12808 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. 74/90 Gene Ontology BP GO:0010633 0.00164804124966149 0.00573547938270376 1935 2550.45454545455 3069 0.000149934282689704 232 1.35195672486041 1.44091882324554 1 10.3498307334436 1931 4018 1167 4161 3249 4305 3669 232 3069 899 1355 3494 M15298 GO_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/57 Gene Ontology BP GO:0032374 0.0159615755036272 0.0297195721562134 4345 3079.81818181818 3069 0.00146168827405751 1053 1.1321903156722 1.09138933279434 1 5.90003549325114 4344 3069 1636 3966 1053 2747 3846 2692 4161 2972 3392 3495 M12222 GO_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JAK_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. 108/201 Gene Ontology BP GO:0046425 0.0104005926978747 0.0213095366900973 3415 2980.18181818182 3071 0.000950008168123856 795 1.19579531297285 1.30639961002653 1 6.82273052993948 3413 1459 795 3071 4031 4557 4255 2755 2375 1490 4581 3496 M12493 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. 21/27 Gene Ontology BP GO:0050687 0.020935668776673 0.0368155422442304 4235 2770.09090909091 3071 0.00192159930969708 859 0.974951539998604 -1.03085946237986 -1 4.76919695214414 4234 1094 3157 859 1147 3098 2753 4033 4103 2922 3071 3497 M12539 GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. 125/222 Gene Ontology BP GO:0071346 0.00910243410814173 0.019207993607793 3075 2999.72727272727 3071 0.000830937705561815 776 1.09608343573844 1.13011271491875 1 6.42190536609753 3071 2986 776 2808 2488 3774 3426 4221 3769 1383 4295 3498 M10864 GO_MATURATION_OF_SSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. 43/44 Gene Ontology BP GO:0030490 0.0210381167890484 0.0369537023100952 810 3051 3072 0.00193109409037548 810 0.479737214061395 0.508355053624054 1 2.33865937251641 810 4077 4147 4622 1149 2569 1807 2317 4535 4456 3072 3499 M15602 GO_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINESIS.html The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. 102/118 Gene Ontology BP GO:0000910 0.126250775457633 0.163339422819136 2730 2934.54545454545 3072 0.0121943006746105 1382 0.815893689384961 -0.846161159839568 -1 2.18441797817939 2729 2060 3986 3274 1837 3072 4133 3676 2031 4100 1382 3500 M15845 GO_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of STAT cascade. 108/201 Gene Ontology BP GO:1904892 0.0104005926978747 0.0213095366900973 3415 2986.09090909091 3072 0.000950008168123856 796 1.19579531297285 1.30639961002653 1 6.82273052993948 3414 1460 796 3072 4032 4558 4256 2809 2376 1492 4582 3501 M12905 GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT.html The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 17/35 Gene Ontology BP GO:0007603 0.00455183050947986 0.0117599485622486 4550 2978.72727272727 3073 0.000414661425485666 712 1.22251337971693 1.58523303421242 1 8.05448092870857 4546 2316 2267 1585 712 3999 4338 1775 3969 3073 4186 3502 M10426 GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. 80/93 Gene Ontology BP GO:0036498 0.000501100005523699 0.002430222775983 3075 2918.63636363636 3074 4.55649253499372e-05 294 0.725705368469673 -0.7523242641018 -1 6.47593747284704 3074 4006 4063 3422 294 2207 2618 2540 3545 4119 2217 3503 M11379 GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY.html The initiation of the activity of the inactive enzyme JUN kinase (JNK). 40/58 Gene Ontology BP GO:0007257 0.0439421981524102 0.0670370649190704 4220 2983.27272727273 3075 0.00407684026496846 1395 1.21908184343426 -1.46928650780235 -1 4.88122900455676 4218 1608 2590 1395 1409 4631 3509 4479 3620 2282 3075 3504 M10549 GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION.html Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. 14/14 Gene Ontology BP GO:1901970 0.0328982300863893 0.0529672887861486 3080 2508.72727272727 3076 0.00303643034096179 39 1.12172211981958 1.45706522201584 1 4.88290652788958 3421 1807 3381 1381 1309 3076 3080 3403 39 3842 2857 3505 M10647 GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition. 14/14 Gene Ontology BP GO:0045842 0.0328982300863893 0.0529672887861486 3425 2513.36363636364 3077 0.00303643034096179 40 1.12172211981958 1.45706522201584 1 4.88290652788958 3422 1808 3382 1382 1310 3077 3081 3444 40 3843 2858 3506 M11697 GO_ORGAN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. 38/46 Gene Ontology BP GO:0048799 0.18204917429484 0.224331252117026 3650 2849.36363636364 3077 0.0181026031549708 1443 1.21703043112823 -1.16696792197555 -1 2.69026087359456 3646 3077 1443 3295 3706 1591 4110 1953 3159 2512 2851 3507 M15715 GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. 14/14 Gene Ontology BP GO:1902101 0.0328982300863893 0.0529672887861486 3425 2519.27272727273 3078 0.00303643034096179 41 1.12172211981958 1.45706522201584 1 4.88290652788958 3423 1809 3383 1383 1311 3078 3082 3491 41 3852 2859 3508 M10221 GO_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 155/226 Gene Ontology BP GO:0045471 0.000222613523322323 0.00136832328139864 3080 2702.36363636364 3080 2.02396411203051e-05 399 1.2008145328644 -1.14903208145919 -1 11.7467766401735 3080 733 399 1763 3657 4546 3681 4145 3050 674 3998 3509 M13704 GO_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_LOCALIZATION.html Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. 27/39 Gene Ontology BP GO:0051647 0.0894562743503784 0.122100335744298 1590 2804.72727272727 3081 0.00848320889047427 930 0.88023720080476 0.854512247890722 1 2.73784888049211 1589 1679 3387 3081 3896 2506 930 3948 3731 3658 2447 3510 M10766 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. 15/21 Gene Ontology BP GO:0043302 0.00231890119429677 0.00722695730546743 295 2177.27272727273 3082 0.000211031730524903 79 0.916179324660511 0.916179324660511 1 6.69587850892123 292 3208 3082 3132 4235 636 79 455 4180 3872 779 3511 M11283 GO_RESPONSE_TO_FUNGICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. 13/20 Gene Ontology BP GO:0060992 9.61837397105049e-05 0.000723009597533085 3020 3004.90909090909 3083 8.74435864633008e-06 137 0.886055510517943 0.804037433078577 1 9.50417452669613 3020 2368 2880 3308 137 4197 4507 3601 3083 3278 2675 3512 M16790 GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of organelle assembly. 57/66 Gene Ontology BP GO:1902117 0.661884965869923 0.691390059851284 3675 2884.72727272727 3083 0.093875902563137 756 0.92893121293439 0.91692139142899 1 0.498371299024482 2675 1553 3671 1927 3368 3083 2460 4519 756 3671 4049 3513 M15864 GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of stem cell proliferation. 73/102 Gene Ontology BP GO:2000648 0.019798209505123 0.0352414188321872 3085 2750.54545454545 3084 0.00181624134709452 905 1.23047235037017 1.27572697297449 1 6.10176775678016 3084 1510 905 1691 3301 4621 3228 3490 2977 1043 4406 3514 M16110 GO_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_PROLIFERATION.html The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. 37/52 Gene Ontology BP GO:0007405 0.00163612418243389 0.0057025361954044 4180 2739.72727272727 3084 0.000148849293145694 230 1.20863571969159 -1.30421567612462 -1 9.26185182872432 4176 3084 2449 4129 3802 4563 2775 230 683 3168 1078 3515 M12575 GO_REGULATION_OF_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_SILENCING.html Any process that affects the rate, extent or location of chromatin silencing. 26/33 Gene Ontology BP GO:0031935 0.0727290109412425 0.102294813639097 2635 2814.45454545455 3085 0.00684098655219258 503 1.05676876497452 0.757321746942653 1 3.56677258958388 2631 3126 3628 3386 4263 2306 2653 1451 503 3927 3085 3516 M15745 GO_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON_REORGANIZATION.html A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. 82/107 Gene Ontology BP GO:0031532 0.664469870897211 0.691390059851284 4045 3164.45454545455 3085 0.0945078617450637 1629 0.958037275699371 0.872145080184142 1 0.514320786332481 4044 2087 2609 1629 4433 3085 4144 2870 3627 2498 3783 3517 M16521 GO_MONOAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOAMINE_TRANSPORT.html The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/24 Gene Ontology BP GO:0015844 0.283145087168377 0.333368950049205 2320 3353.27272727273 3085 0.0298086732909296 2242 0.599379141933643 -0.599379141933643 -1 0.96698087674575 3776 4238 3053 4049 2242 2318 3085 2589 4577 4641 2318 3518 M11378 GO_CRANIAL_NERVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 37/59 Gene Ontology BP GO:0021602 0.0243583376488444 0.0416995382928893 4600 2905.36363636364 3086 0.0022392989495061 936 1.22143167352784 -1.18847713076661 -1 5.75168383479474 4596 3086 1554 3802 3535 2040 4305 936 3888 2433 1784 3519 M13530 GO_PHAGOSOME_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_ACIDIFICATION.html Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. 25/30 Gene Ontology BP GO:0090383 0.521849762467263 0.572141127417572 3020 3050.18181818182 3086 0.0648753855032414 1118 0.876859494625607 1.10145618319243 1 0.716327362307238 3017 2764 3332 2615 4524 3086 2181 3810 1118 3563 3542 3520 M11807 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. 36/47 Gene Ontology BP GO:0010881 0.123665187728179 0.160595623360094 1490 2884.81818181818 3088 0.0119289208761063 1149 0.711767343571354 0.741991127157519 1 1.92218039551198 1490 3088 2727 4201 2530 3177 1397 3754 4266 3954 1149 3521 M13644 GO_OUTER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 34/61 Gene Ontology BP GO:0036158 0.00889726539186767 0.0188262737009369 2905 2814.63636363636 3088 0.000812132079228451 599 1.27550270541091 1.2294413145595 1 7.51287701859618 2905 3418 1300 3244 3541 4172 3088 599 3038 2232 3424 3522 M16916 GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. 18/21 Gene Ontology BP GO:0046112 0.0702197729476317 0.0993410165780876 2480 2848.90909090909 3088 0.00659696528130436 426 0.909705902166114 -1.01731252394725 -1 3.10850460895726 2476 3856 3765 3144 1580 2741 3395 2860 426 4007 3088 3523 M13887 GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 36/43 Gene Ontology BP GO:0010800 0.68618940391 0.691390059851284 4020 2994 3089 0.1 914 1.12937421099547 -1.17679719572809 -1 0.608209688344486 4016 3089 2428 2912 4619 2325 3351 3856 914 2003 3421 3524 M11478 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. 40/48 Gene Ontology BP GO:1902883 0.369661119913267 0.422582720605585 2090 3201.36363636364 3090 0.0410864328871879 2088 0.947050895661545 1.07076833203684 1 1.20060408399413 2088 3399 3025 4219 2991 3589 3090 2377 4066 3574 2797 3525 M15931 GO_MELANOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. 25/30 Gene Ontology BP GO:0030318 0.197289415491465 0.24075207193333 3220 2900.45454545455 3090 0.0197800336773963 1410 1.32505275267909 1.26277684602622 1 2.79100165969473 3216 2256 1581 3090 4278 2527 1410 3946 4091 1885 3625 3526 M10938 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 85/136 Gene Ontology BP GO:0042993 0.124114515273971 0.160999397705544 1510 2830.54545454545 3091 0.0119749878537763 1507 0.978952509118591 1.05104791591652 1 2.6440862759384 1507 4002 3149 4078 2279 3158 2329 1743 3798 3091 2002 3527 M15263 GO_OLIGODENDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DEVELOPMENT.html The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. 34/53 Gene Ontology BP GO:0014003 0.568409040400217 0.616648930982096 3095 2789.63636363636 3091 0.0735440857158205 961 1.17272685575875 1.29555941321176 1 0.831178167687967 3091 961 1885 1562 3100 3196 4594 3501 2734 2233 3829 3528 M15700 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. 40/48 Gene Ontology BP GO:1900408 0.489380644135374 0.539338734524371 2090 3222.27272727273 3091 0.0592734775960545 2089 0.947050895661545 1.07076833203684 1 0.8575471570291 2089 3400 3026 4220 2992 3590 3091 2596 4067 3576 2798 3529 M16555 GO_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING.html Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 51/70 Gene Ontology BP GO:0060968 0.260382815330783 0.309387446305958 4450 2928.18181818182 3093 0.0270477094338286 167 1.22761068850561 -1.52940471349898 -1 2.12776695193143 4450 890 3093 1898 2197 4366 4128 4254 167 2624 4143 3530 M10854 GO_LUNG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_CELL_DIFFERENTIATION.html The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. 24/33 Gene Ontology BP GO:0060479 0.064814575037854 0.0925666720844489 3600 3178.27272727273 3096 0.0060733416902029 1547 1.20571595392122 -1.29919632431819 -1 4.24989997005906 3596 3811 3096 2417 1547 4499 4241 3093 3879 2254 2528 3531 M11905 GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 70/125 Gene Ontology BP GO:1903557 0.474730893261387 0.524684761602193 2465 3013.18181818182 3098 0.056851303205914 1767 1.12763442212408 1.25797639086832 1 1.06921913810341 1890 3342 1767 3098 4646 2942 2464 3711 3611 2461 3213 3532 M16761 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 35/43 Gene Ontology BP GO:1902175 0.68618940391 0.691390059851284 2540 3192 3099 0.1 2539 0.822045591605205 0.819502732621829 1 0.439800310754351 2539 3099 3593 2965 3172 2998 3086 3130 3760 3936 2834 3533 M11463 GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL.html The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. 1776/2289 Gene Ontology BP GO:0051649 0.399111739154424 0.45096331284253 3925 3248.45454545455 3101 0.0496592061796208 2172 0.920633261137077 -0.910076951692646 -1 1.07796123461043 3924 3613 4303 3100 2480 2301 4092 3101 2215 4432 2172 3534 M13212 GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. 21/26 Gene Ontology BP GO:0030859 0.127785408690859 0.164817665351166 2520 2910.09090909091 3101 0.0123521503189645 1105 1.05321688471464 0.953169783167046 1 2.80882303606429 2520 3821 2632 3780 3366 2289 1105 1886 4134 3377 3101 3535 M16354 GO_REGULATION_OF_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of organ morphogenesis. 239/309 Gene Ontology BP GO:2000027 0.00165382677081352 0.00575131238011607 3105 2211.63636363636 3101 0.000150461029785338 110 1.15485987631832 -1.04236550319753 -1 8.8346849480804 3101 667 548 110 3408 3518 3938 3451 1101 537 3949 3536 M16571 GO_COFACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. 163/181 Gene Ontology BP GO:0051188 0.10010938793203 0.133930127098257 3510 3049.72727272727 3101 0.00954344813208175 1748 0.868742259947103 -0.708908423753383 -1 2.58266948841648 3510 2530 3797 1970 1748 2659 3101 4268 2345 3628 3991 3537 M14803 GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 40/51 Gene Ontology BP GO:0046685 0.0901984052260827 0.122861001029556 3400 2731.18181818182 3102 0.00855670223821679 1234 0.982001393616813 0.804909845214143 1 3.04654863483908 2670 3397 3102 3535 1695 1421 1234 3399 2559 3336 3695 3538 M16532 GO_CELLULAR_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_DEFENSE_RESPONSE.html A defense response that is mediated by cells. 52/121 Gene Ontology BP GO:0006968 0.682794476204424 0.691390059851284 2110 3003.27272727273 3102 0.0991191813134866 2106 1.21723868414401 1.48862789788444 1 0.656357502448451 2106 3366 2454 3102 3676 2299 2502 3837 3112 2678 3904 3539 M15885 GO_NAD_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. 11/16 Gene Ontology BP GO:0009435 0.293040249428668 0.344061640320866 2475 3041.36363636364 3104 0.0310338445163788 1668 1.08184868831763 -1.29758736726037 -1 1.70321954709394 2473 4250 3104 3584 2364 2370 1668 3250 4558 3682 2152 3540 M16666 GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 23/39 Gene Ontology BP GO:0035458 0.0129327621022056 0.0252099464019952 2735 2977.45454545455 3104 0.00118267448550574 726 0.853616458358242 -0.971191679078187 -1 4.65430126336861 2735 4170 3247 4589 1410 2496 2535 726 4256 3484 3104 3541 M11845 GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 151/171 Gene Ontology BP GO:0035967 0.000591277078150862 0.00274298329475171 3710 2907.54545454545 3105 5.37669137238798e-05 317 0.86240670730626 -0.84641651614709 -1 7.54279558227884 3710 3305 4053 2218 317 2967 3709 3105 1426 4123 3050 3542 M11460 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 45/65 Gene Ontology BP GO:0010765 0.0866130529986706 0.11856738323119 3110 3017.45454545455 3107 0.00820214721730988 923 0.816033781170424 0.909673187546077 1 2.57295255026728 3107 923 2273 3742 3836 3813 4425 1527 4193 2946 2407 3543 M11909 GO_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSPORT.html The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 215/370 Gene Ontology BP GO:0015849 5.81737940996202e-09 1.91973520528747e-07 3430 2108.63636363636 3107 5.28852675031335e-10 105 1.23748049641826 1.16649217661677 1 28.4071419067166 3429 675 105 248 3163 3565 3107 3336 1333 107 4127 3544 M11554 GO_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_ENGULFMENT.html The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. 30/159 Gene Ontology BP GO:0006911 0.0106535367353371 0.0217035492248352 4320 2954 3109 0.000973225377516784 856 1.17947931385931 1.14024750635725 1 6.69740624123825 4316 3109 1203 2110 923 4330 4075 3021 4142 856 4409 3545 M15153 GO_REGULATION_OF_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_MOVEMENT.html Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. 14/27 Gene Ontology BP GO:0003352 0.68618940391 0.691390059851284 4430 3046.45454545455 3110 0.1 1797 1.05798427899023 -1.40984374076845 -1 0.569089563316567 4427 1797 2235 2354 3282 4078 3314 3345 2771 2798 3110 3546 M10128 GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. 88/111 Gene Ontology BP GO:0043407 0.635286119203633 0.680789109317021 4585 3282.09090909091 3111 0.0876163771625208 1749 1.1945349583137 -1.22455225854629 -1 0.671322517693272 4582 3002 2692 3111 3521 4160 4244 3012 1782 1749 4248 3547 M14396 GO_MRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION.html The cellular synthesis of messenger RNA (mRNA) from a DNA template. 26/33 Gene Ontology BP GO:0009299 0.00681245211157782 0.0152836739031686 245 2055.72727272727 3112 0.000621239931641912 242 1.0058758844354 1.00735745710619 1 6.23384466364906 242 3132 3121 4206 3112 820 289 530 3290 3261 610 3548 M16819 GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 50/55 Gene Ontology BP GO:0010823 0.0743951256522002 0.104042794497179 3115 2867.63636363636 3112 0.00700334664454182 1464 0.896115614629825 -0.952961210975994 -1 3.00037572544913 3112 3734 3372 2233 2129 2031 3504 1464 4241 3461 2263 3549 M11972 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. 73/145 Gene Ontology BP GO:0002718 0.0118237577020373 0.0235010442492864 2110 2788 3113 0.00108070781877293 695 1.1754191234913 1.31256255728157 1 6.5354429954057 2107 4021 1909 4207 3774 3654 2351 695 3549 1288 3113 3550 M15836 GO_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that modulates the frequency, rate or extent of viral genome replication. 95/138 Gene Ontology BP GO:0045069 0.312452077119925 0.364827983648434 2345 3071.90909090909 3113 0.0334833024429181 1175 1.20145025492664 1.40483854620263 1 1.78814569794581 2345 4340 3113 4423 2291 3557 3279 2740 1175 2779 3749 3551 M14133 GO_TOXIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_TRANSPORT.html The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/59 Gene Ontology BP GO:1901998 0.0345722932900848 0.0552420606726526 3810 3022.90909090909 3114 0.003193440672753 1325 1.11554362941238 -1.09929964854124 -1 4.78630107404214 3806 4045 3300 3855 1325 2497 2671 2857 3114 3727 2055 3552 M10305 GO_URETER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_URETER_DEVELOPMENT.html The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. 14/21 Gene Ontology BP GO:0072189 0.155310095258343 0.195630176837322 3085 3016 3115 0.0152270324233235 1645 1.6576399776159 -1.8808319091191 -1 4.00504230535869 3085 3910 1645 3115 3530 4307 4119 1855 3188 2210 2212 3553 M11324 GO_PITUITARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PITUITARY_GLAND_DEVELOPMENT.html The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. 29/63 Gene Ontology BP GO:0021983 0.0084947866392629 0.0181638866619536 4115 2875.63636363636 3115 0.000775251426474732 767 1.82327018667873 -2.0745838122802 -1 10.8408462469724 4112 3115 767 3083 4342 2269 3966 3953 1476 1069 3480 3554 M10931 GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 50/61 Gene Ontology BP GO:0043647 0.0120912719300333 0.0238797488499341 4555 2683.45454545455 3118 0.00110529471110457 184 0.837076608005096 -0.941134673711668 -1 4.63128776945789 4554 184 3118 1019 962 4319 3749 4012 1267 4070 2264 3555 M14326 GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS.html The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. 13/16 Gene Ontology BP GO:0060670 0.123787132882249 0.16070913205946 3570 3049.36363636364 3119 0.011941421090344 1784 1.13284733348373 -1.05967701069756 -1 3.06445765237897 3567 3222 2568 3129 1831 4015 4643 2962 1784 2703 3119 3556 M16786 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. 18/19 Gene Ontology BP GO:1990440 0.427194874121326 0.478396570225398 1325 2913.18181818182 3120 0.049393834193159 1325 0.979934217647304 1.02645895269569 1 1.06215727261177 1325 3883 2618 3862 3186 1836 2141 3120 4601 3153 2320 3557 M10974 GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. 98/165 Gene Ontology BP GO:0048525 0.622804195125601 0.668645113040937 2895 3273.63636363636 3121 0.0848209335558406 1742 1.20650913901414 1.43617421229265 1 0.710403577246772 2894 4341 2696 4058 2840 4082 3773 3121 2281 1742 4182 3558 M14855 GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 28/30 Gene Ontology BP GO:0032878 0.0685906906058852 0.0974702970729089 850 2866.72727272727 3121 0.0064388587190408 812 0.850361295790159 0.869206350618126 1 2.92902983175956 847 4468 3649 4459 3121 1508 812 2127 4586 3690 2267 3559 M10378 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 16/17 Gene Ontology BP GO:0090141 0.320957895210505 0.373447633511998 3070 3358.81818181818 3124 0.0345764641416894 2279 0.90823982835751 -1.02635615320371 -1 1.31765990719583 3066 3548 3201 3095 4625 2533 3124 2279 4512 3904 3060 3560 M12852 GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 86/96 Gene Ontology BP GO:0070301 0.160310538721391 0.201012919459148 3555 3026.63636363636 3126 0.0157584380025581 1483 0.907915672278443 0.854384108402368 1 2.15221082016528 3554 1483 3103 2227 1963 3628 3221 4362 2854 3126 3772 3561 M16038 GO_PEPTIDYL_ARGININE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_METHYLATION.html The addition of a methyl group to an arginine residue in a protein. 11/14 Gene Ontology BP GO:0018216 0.226365872529311 0.27216547929687 3660 3224 3126 0.0230622883675399 2137 0.445589010545081 -0.465623201318408 -1 0.850338258427009 3657 2892 3615 3082 2137 3126 2401 3030 3384 4624 3516 3562 M14310 GO_RHYTHMIC_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_BEHAVIOR.html The specific behavior of an organism that recur with measured regularity. 19/32 Gene Ontology BP GO:0007622 0.426529328343679 0.477766240920351 2645 3404 3127 0.0492934767196187 2024 0.904354101072804 0.876839049211644 1 0.981183523304494 2643 4518 3055 4530 2476 3127 2024 2714 4445 4029 3883 3563 M11985 GO_SPERM_CAPACITATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_CAPACITATION.html A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. 13/27 Gene Ontology BP GO:0048240 0.00225776982206421 0.00709345238491881 290 2346 3128 0.00020546274665664 289 1.03052870324138 1.03052870324138 1 7.56146079146997 1828 4570 3256 3336 3928 1166 735 290 3128 3280 289 3564 M12152 GO_INNER_CELL_MASS_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_CELL_MASS_CELL_PROLIFERATION.html The proliferation of cells in the inner cell mass. 10/11 Gene Ontology BP GO:0001833 0.373404727534442 0.426264032683454 3945 3164.36363636364 3130 0.0416055654477185 633 0.503599647632186 -0.353699147768472 -1 0.626949347666585 3942 2901 3636 2171 3130 4291 3026 2384 633 4499 4195 3565 M13799 GO_PROTEIN_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION.html The process in which one or more ubiquitin groups are added to a protein. 590/718 Gene Ontology BP GO:0016567 0.0781598242903422 0.108495722679881 2705 2850.45454545455 3130 0.00810531491992946 941 0.835355152012113 -0.805561450189174 -1 2.7442328883165 2702 3275 4449 3242 3010 1406 3130 3161 1663 4376 941 3566 M13890 GO_OOCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. 25/45 Gene Ontology BP GO:0001556 0.0121478141037018 0.023950753823951 2400 2787.45454545455 3130 0.00111049220517384 269 1.0763042366448 0.718526108790237 1 5.95316317119421 2397 3130 2129 3349 4542 551 269 4180 2920 3564 3631 3567 M15704 GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. 245/343 Gene Ontology BP GO:0043123 0.677605827079705 0.691390059851284 2145 3057 3130 0.0977893989643064 2143 1.02547679279588 1.09551045624318 1 0.551276170187505 2143 3289 3009 3001 3930 2575 2501 3531 3141 3130 3377 3568 M11752 GO_PURINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. 16/17 Gene Ontology BP GO:0043101 0.0256539919592492 0.0435649724767834 1665 2641.27272727273 3131 0.00235982885464905 955 1.08930030160828 -1.08930030160828 -1 5.05754380898716 1664 3213 3440 3977 3131 1939 2023 955 3749 3499 1464 3569 M12215 GO_MEMBRANE_TUBULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_TUBULATION.html A modification in a plasma membrane resulting in formation of a tubular invagination. 11/14 Gene Ontology BP GO:0097320 0.000441319927935501 0.00223445225754503 3885 2568.63636363636 3131 4.01280437789987e-05 279 0.937341418288981 1.0384928944308 1 8.48450433806134 3884 2390 3131 1579 279 3251 2000 3232 305 3674 4530 3570 M15614 GO_PROTEIN_PALMITOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PALMITOYLATION.html The covalent attachment of a palmitoyl group to a protein. 21/26 Gene Ontology BP GO:0018345 0.000656083488546882 0.00296096651038666 4185 2563.36363636364 3132 5.96617479399668e-05 330 0.853636393428838 -0.908901404494397 -1 7.3690544696611 4184 1067 3132 522 330 4584 3977 2639 627 3382 3753 3571 M16278 GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 15/19 Gene Ontology BP GO:0060315 0.000835704249558275 0.00349688118093044 3530 2782.18181818182 3132 7.60019885233483e-05 370 0.774989480159933 -0.721848751691175 -1 6.4977189411287 3528 1151 2783 2134 370 3132 4597 2148 3986 3449 3326 3572 M16246 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. 28/42 Gene Ontology BP GO:1901381 0.0728702002224162 0.102436568469759 3620 2965.72727272727 3134 0.00685473492238423 1533 1.19560965381348 -1.02250102707726 -1 4.03432648954326 3616 2725 1588 3468 1596 3134 4078 4026 1533 2569 4290 3573 M10665 GO_KERATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 31/38 Gene Ontology BP GO:0042339 0.0080993556683181 0.0174923287764597 4445 2723.90909090909 3135 0.000739029840738675 760 1.3999028533398 -1.35520980283565 -1 8.39940972806267 4443 1643 760 1958 3223 4057 3848 3135 1699 1244 3953 3574 M15786 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 19/22 Gene Ontology BP GO:1902043 0.146202824683571 0.185261912650506 4350 3203.27272727273 3136 0.014266492764493 1915 1.32210764014568 1.00713353957092 1 3.29910238576278 4346 4174 2712 3335 1915 2511 3801 3136 2860 2735 3711 3575 M15868 GO_DNA_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. 17/17 Gene Ontology BP GO:0006266 0.00178441138212918 0.0060428429119702 1525 2577.72727272727 3136 0.000162350941530841 244 1.30745724241497 -1.30745724241497 -1 9.90747155685049 1524 4200 3861 4403 3136 1044 1048 244 3840 3972 1083 3576 M16259 GO_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. 1673/2309 Gene Ontology BP GO:0009056 0.0849188956616856 0.116556820505553 4480 3063 3136 0.00883499789502469 1258 1.05797412405546 -1.00863338473097 -1 3.36581778847181 4478 1258 4609 1441 1714 2495 4311 4339 2082 3830 3136 3577 M10269 GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 18/26 Gene Ontology BP GO:0051284 0.00199237272894692 0.0065010591218724 4130 2981.72727272727 3137 0.000181289032767133 515 0.797797708392264 -0.768719253489853 -1 5.95470386993354 4128 1107 2730 2588 515 2173 3560 4482 3778 3137 4601 3578 M11958 GO_MITOTIC_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_ARREST.html The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M). 17/18 Gene Ontology BP GO:0071850 0.00447881160892244 0.0116424080538079 3350 2843 3138 0.000407995977409386 706 1.19767145639598 -1.06129077838192 -1 7.90845812162648 3346 3859 2432 3480 706 4052 4458 2040 1210 2552 3138 3579 M12798 GO_MAINTENANCE_OF_LOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION.html Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. 157/197 Gene Ontology BP GO:0051235 0.622317893089514 0.668277211295986 4585 3386.36363636364 3138 0.0847137326999123 2178 1.03553573560098 -0.971677921476042 -1 0.609068119240317 4583 3983 2835 3094 3894 2193 3814 4509 3138 2178 3029 3580 M13754 GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION.html The directed movement of the nucleus to a specific location within a cell. 19/29 Gene Ontology BP GO:0040023 0.0073280102119552 0.0162021781295408 1280 2593.63636363636 3139 0.000668412147070235 187 1.0227917824327 1.02148395592231 1 6.25022862176304 1280 3168 3139 3764 4149 2107 187 3034 3970 3235 497 3581 M12552 GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 129/187 Gene Ontology BP GO:0042990 0.109560576038206 0.144578945066867 1705 2947.81818181818 3140 0.0104936626801485 1606 0.955797242573769 1.03761240509925 1 2.73396317652208 1704 3987 3465 4061 3140 2885 2841 1664 3606 3467 1606 3582 M14864 GO_ERROR_PRONE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_PRONE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 21/25 Gene Ontology BP GO:0042276 0.183886263077826 0.226475061434919 1215 2959.18181818182 3140 0.018303290575034 1215 0.948941459678065 -1.02957692731053 -1 2.08189681541479 1215 3832 3473 3140 4618 2357 2657 1956 3841 3380 2082 3583 M15463 GO_RECIPROCAL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_DNA_RECOMBINATION.html A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules. 30/42 Gene Ontology BP GO:0035825 0.381784550531095 0.433819064876804 2880 3224.54545454545 3140 0.0427779063608993 1728 0.749954014296026 -0.749954014296026 -1 0.919297262393622 2879 3792 3906 4410 2850 1728 2658 3140 3442 4201 2464 3584 M12495 GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 1776/2298 Gene Ontology BP GO:0044093 0.0194529745665109 0.0347999579615437 2770 2869.45454545455 3141 0.00196253907978624 632 1.09670679754257 1.14169325796863 1 5.45780866132384 2767 1254 4371 1180 3625 4256 3331 3141 2768 632 4239 3585 M12041 GO_BILE_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. 18/33 Gene Ontology BP GO:0006699 0.000804564674714823 0.00340651452338174 3035 2732 3142 7.31690057979228e-05 365 1.31453710169204 -1.33706301595538 -1 11.0799572111747 3034 3864 1537 4126 365 3421 3652 507 4442 3142 1962 3586 M12873 GO_CEREBRAL_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_DEVELOPMENT.html The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. 144/190 Gene Ontology BP GO:0021987 0.0300039774364629 0.0491925676574566 3145 2815.27272727273 3143 0.00276556040372454 976 1.14606087068077 -1.00900757500627 -1 5.11489601840683 3143 2543 976 2731 1416 4257 3487 3875 3367 1324 3849 3587 M16218 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. 760/1067 Gene Ontology BP GO:0000122 0.224605540056875 0.270258489238335 1595 3175.81818181818 3143 0.0251175114912451 1543 1.06505094748746 1.01758352868412 1 2.05842933518354 1594 4616 4604 4543 2819 1912 1543 3143 2953 3896 3311 3588 M16236 GO_SNRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. 83/91 Gene Ontology BP GO:0016073 0.312861252151986 0.365030944398995 2805 3374.72727272727 3144 0.0335356070972784 1564 0.536929412659621 -0.570928739312301 -1 0.792783288361069 2803 4007 4177 4110 2815 1564 2668 3144 4137 4628 3069 3589 M12673 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that modulates the frequency, rate or extent of protein localization to the cell surface. 37/46 Gene Ontology BP GO:2000008 0.0352977379177069 0.0562467036065378 3150 2950.81818181818 3146 0.00326155697969964 1114 1.02443677215757 1.14530623142252 1 4.36711653192144 3146 1618 2864 1415 4405 4525 3460 1114 3402 2807 3703 3590 M11231 GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS.html The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 51/987 Gene Ontology BP GO:0007606 0.000100409241767736 0.000748724682604605 4030 2548.81818181818 3147 9.12852952682256e-06 167 1.49509692990832 1.4630585624234 1 15.9667326146858 4028 167 353 931 4527 4551 4642 3537 1468 686 3147 3591 M11493 GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 113/180 Gene Ontology BP GO:0051282 0.0234996235190521 0.0404377767138126 3150 2630.90909090909 3148 0.00215949611904729 18 0.992557043161235 -1.00575540542501 -1 4.71720508578112 3148 18 936 824 1850 4371 3842 4573 3491 1702 4185 3592 M15643 GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. 28/31 Gene Ontology BP GO:0046827 0.0468994336151271 0.0706680908714982 675 2557.36363636364 3148 0.00435728435071596 596 0.748801888282523 0.778233597568338 1 2.9354569467761 673 3794 3607 3662 3148 596 640 1844 4390 4182 1595 3593 M10984 GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 118/163 Gene Ontology BP GO:0007249 0.155911039331862 0.196227770086869 1500 2935.18181818182 3150 0.0152907443398687 1499 1.03536130464257 1.03303695319999 1 2.49285616314486 1499 3662 3424 4392 1952 2934 2250 2057 3150 3654 3313 3594 M11935 GO_REGULATION_OF_GLOMERULAR_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULAR_FILTRATION.html Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. 8/13 Gene Ontology BP GO:0003093 0.00280931312868514 0.00832594521514136 455 2634.54545454545 3150 0.000281287096865393 102 0.856884682142046 0.856884682142046 1 6.08172589084783 451 4602 4333 4400 3150 1156 102 1931 4245 3488 1122 3595 M13792 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. 137/189 Gene Ontology BP GO:1903747 0.126439619673651 0.163468616377188 3135 2925 3151 0.0122137112494094 1766 0.876225928718966 -0.899459041804755 -1 2.34570720157681 3131 3309 3687 2437 1839 1766 3452 3151 3166 4130 2107 3596 M15131 GO_HISTONE_H4_K16_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K16_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. 21/21 Gene Ontology BP GO:0043984 0.323270843285104 0.375669139312085 2425 2873.81818181818 3152 0.0348758751195636 1749 1.28650967482308 0.758853337659659 1 1.85955896159598 2423 4166 3562 3393 3256 1763 1749 3152 1947 3381 2820 3597 M15274 GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that activates or increases the frequency, rate or extent of blood circulation. 83/135 Gene Ontology BP GO:1903524 7.95616274098742e-08 2.01195789314209e-06 3400 2828.81818181818 3152 7.23287548065191e-09 138 1.59527617484036 -1.75094557242357 -1 31.0583414647224 3399 3011 138 3751 3152 3662 4349 2494 2470 248 4443 3598 M12579 GO_MAINTENANCE_OF_LOCATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION_IN_CELL.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. 112/136 Gene Ontology BP GO:0051651 0.212723071222257 0.257157820316228 3155 3107.63636363636 3153 0.0215085217947838 1423 0.862746550483253 -0.903020714142944 -1 1.72906229015144 3153 4322 3777 3849 3025 1423 2960 2760 3748 3665 1502 3599 M12478 GO_NCRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_TRANSCRIPTION.html The transcription of non (protein) coding RNA from a DNA template. 92/106 Gene Ontology BP GO:0098781 0.308024123125406 0.360381253432867 2920 3247 3155 0.0329190820248113 1548 0.783353904710162 -0.903784113894383 -1 1.17643705413159 2920 4003 4148 4111 3498 1548 3155 2656 3094 4380 2204 3600 M15415 GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. 13/13 Gene Ontology BP GO:1904293 3.4334460129605e-05 0.000335904000263133 4365 2458.36363636364 3156 3.12136327132401e-06 77 0.978346411352882 1.08403935796646 1 11.6088518845605 4361 1193 3236 1105 77 3156 2183 3426 302 3815 4188 3601 M11474 GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 17/18 Gene Ontology BP GO:0051571 0.000699456914374359 0.00308764126631786 4635 2825.81818181818 3157 6.36072177468836e-05 153 1.17331561617411 0.916898809484438 1 10.0597101364943 4635 3539 3366 2669 342 3681 3784 3157 153 3072 2686 3602 M12978 GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. 5/26 Gene Ontology BP GO:0002827 0.0065486506086056 0.0148132577937977 2875 3026.63636363636 3158 0.000656802920047411 821 1.00923608467897 1.00923608467897 1 6.30155329351069 2874 4268 4397 4362 821 2517 2098 1116 4449 3158 3233 3603 M14567 GO_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 102/134 Gene Ontology BP GO:0072091 0.0398506069762035 0.0620386872092917 2680 2786.81818181818 3158 0.00369011915931462 1039 1.24500163489516 1.28762761770338 1 5.12848370259246 2678 2059 1039 3169 4041 3561 2447 4166 3158 1068 3269 3604 M13685 GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of epidermis development. 38/47 Gene Ontology BP GO:0045684 0.109185188706646 0.144124449092773 3920 3117.45454545455 3159 0.0104557470813175 1781 1.40662170239 1.29668568251499 1 4.03510715634073 3920 3750 2277 3772 1781 3159 2917 3513 3022 2149 4032 3605 M13939 GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. 5/18 Gene Ontology BP GO:0032645 0.0286016882924284 0.0474959513292895 2605 3243.81818181818 3159 0.00289766235586759 495 1.39977208338868 1.39977208338868 1 6.32252414428676 2605 4608 4461 4382 4231 2232 495 1846 4568 3159 3095 3606 M11649 GO_TONGUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TONGUE_DEVELOPMENT.html The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. 15/29 Gene Ontology BP GO:0043586 0.00240108130446446 0.00737928091788185 3160 3042.45454545455 3160 0.000218518714283086 298 1.09861078675164 -1.09861078675164 -1 7.99727366541362 3160 4229 2850 4090 1353 3061 3637 298 4569 3875 2345 3607 M14168 GO_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING.html Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. 179/252 Gene Ontology BP GO:0016458 0.381696556775648 0.433819064876804 2665 3115.18181818182 3160 0.0427655211350165 970 1.03704299796743 -1.05343471851282 -1 1.27529411804049 2661 3975 4077 3863 4337 2432 3160 2470 970 4301 2021 3608 M16540 GO_THYROID_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. 14/35 Gene Ontology BP GO:0030878 0.00604863057276213 0.0138984089160801 2810 2759.45454545455 3160 0.000551393166870503 150 0.914536610029671 -0.597177612962463 -1 5.79582591458431 2807 4557 3160 4075 3338 754 1849 1834 4459 3371 150 3609 M16327 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. 29/37 Gene Ontology BP GO:0000083 0.136079865831522 0.174203743457432 1290 2866.45454545455 3161 0.0132096987752902 1100 0.965815666468866 1.03536821403394 1 2.49542081350812 1287 4121 3541 4176 4607 1100 1152 2568 2093 3725 3161 3610 M15291 GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of macrophage differentiation. 20/25 Gene Ontology BP GO:0045649 0.000366917024768965 0.00195562991552118 4030 2666.18181818182 3163 3.33616576048698e-05 256 1.53427075753353 -1.78385061908152 -1 14.1981394867548 4029 3163 788 2064 256 3915 4460 3621 1453 1392 4187 3611 M16153 GO_GLYCEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROL_TRANSPORT.html The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. 5/11 Gene Ontology BP GO:0015793 0.0700841825864898 0.0991978407150756 2725 3128.63636363636 3163 0.007239787144457 1626 1.11459678042491 -1.11459678042491 -1 3.81341416886147 2722 3611 4598 2540 1626 3595 2844 3252 4375 3163 2089 3612 M11762 GO_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_PROCESS.html Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. 549/703 Gene Ontology BP GO:0007017 0.135214665172882 0.173349869671727 2490 2767.27272727273 3165 0.0144223835743771 1071 1.01175160607553 -1.06963447544129 -1 2.62199632767201 2489 3277 4323 2001 4113 1071 3165 3205 1465 4039 1292 3613 M11797 GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 37/46 Gene Ontology BP GO:0043516 0.00780103113941946 0.016969704484207 2935 3196.36363636364 3165 0.000711711918409069 844 1.25122304261922 -1.17888493798767 -1 7.5625530206354 2935 4096 2544 4235 844 3015 1701 4382 4076 3165 4167 3614 M13062 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. 34/35 Gene Ontology BP GO:0000462 0.0109153800779193 0.0220822884793732 1215 3162.36363636364 3165 0.000997265120781541 930 0.401656556924388 0.413786790628931 1 2.26336653302788 1212 4450 4120 4623 930 2652 1963 2544 4595 4532 3165 3615 M11568 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of epithelial cell proliferation. 186/243 Gene Ontology BP GO:0050679 2.24982469296933e-07 4.80203408091115e-06 3035 2905.72727272727 3166 2.04529538458831e-08 166 1.3894876894821 -1.37088871420483 -1 25.2556803297119 3031 3639 166 3166 3567 3581 3030 4460 2471 369 4483 3616 M12813 GO_CELL_REDOX_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_REDOX_HOMEOSTASIS.html Any process that maintains the redox environment of a cell or compartment within a cell. 59/76 Gene Ontology BP GO:0045454 0.00232948491680139 0.00724054329851495 3170 2927.09090909091 3166 0.000211995924579945 549 1.0347560799906 -0.932241059726431 -1 7.56098876832719 3166 3352 3140 2316 549 3366 3905 2920 2645 3316 3523 3617 M14074 GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 285/421 Gene Ontology BP GO:0045089 0.68618940391 0.691390059851284 4290 2953.72727272727 3166 0.1 659 1.025010110018 -0.996677209367317 -1 0.551020438208134 4286 659 2535 1313 3803 3166 4574 3635 2457 3211 2852 3618 M13717 GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 9/34 Gene Ontology BP GO:0002323 0.00106560420769416 0.00415612437418351 3675 2709 3167 0.000106611553336007 38 1.49152308431859 -1.014721833676 -1 12.1326896808812 3675 1241 4446 1070 3984 4532 4569 198 38 2879 3167 3619 M15030 GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. 37/44 Gene Ontology BP GO:0031062 0.00378857183517243 0.010384592062893 3310 2907.36363636364 3167 0.000345010165868101 654 1.29627391189409 0.870021636586808 1 8.78048561955007 3306 3090 3286 3178 654 2477 1402 4289 2593 3167 4539 3620 M16721 GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. 19/30 Gene Ontology BP GO:0090025 0.0895359146075013 0.122137382195457 3290 2890.54545454545 3167 0.00849109306995373 1234 1.53298887649356 -1.39751221910038 -1 4.77535392572093 3290 3167 1234 1510 2572 4620 3859 4615 1450 1739 3740 3621 M16782 GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 333/547 Gene Ontology BP GO:0034762 4.86731350079086e-11 2.97994864726051e-09 3490 2711.27272727273 3167 4.42483045536231e-12 52 1.23445802752783 -1.30685619685557 -1 35.9728401641044 3489 1937 52 1969 3167 4248 3780 4357 2819 289 3717 3622 M10127 GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION.html Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. 20/22 Gene Ontology BP GO:0051900 0.00531201568640266 0.0131766533742567 4080 2871.18181818182 3170 0.000484080486632492 697 1.96678819362026 -1.6090336202771 -1 12.6324169403082 4076 3170 697 3294 4176 4165 4104 2214 1299 1385 3003 3623 M15070 GO_MOTILE_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM_ASSEMBLY.html The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function. 33/57 Gene Ontology BP GO:0044458 0.0106978336226499 0.0217747243421654 2890 2864.45454545455 3170 0.000977291852321512 655 1.16215767977974 1.16820097784236 1 6.59324293782033 2887 3434 1987 2859 3466 4416 3170 655 3381 1746 3508 3624 M15348 GO_REGULATION_OF_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPIRATION.html Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. 28/34 Gene Ontology BP GO:0043457 0.457572832486718 0.507046056099237 2195 3027.18181818182 3170 0.0540912972172415 1921 0.873132806212234 -0.929327277862744 -1 0.869828298923123 2742 3791 3170 3403 2528 1921 2195 3587 4372 3395 2195 3625 M16828 GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION.html Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. 24/26 Gene Ontology BP GO:2000615 0.218116292117767 0.263062495392423 2095 2938 3170 0.0221198031937514 1324 0.671549436653201 0.697640354530303 1 1.32087741689961 2094 2766 3633 3428 3815 1324 1878 3170 3717 4651 1842 3626 M11765 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 18/20 Gene Ontology BP GO:0034383 0.00925766463055095 0.0194737402920224 3765 2581.72727272727 3171 0.000845168383094301 518 1.71091014997968 1.73962256651046 1 9.99522329597835 3764 3171 1280 1110 887 4475 4355 3291 518 1182 4366 3627 M12551 GO_VESICLE_CYTOSKELETAL_TRAFFICKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_CYTOSKELETAL_TRAFFICKING.html The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. 49/56 Gene Ontology BP GO:0099518 0.00687054075743906 0.0153769245523636 3175 2497.36363636364 3171 0.000626553777623358 590 0.921083296861743 -1.10320363362553 -1 5.69913062303008 3171 3370 3749 2144 812 3655 3941 926 1249 3864 590 3628 M12554 GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. 18/26 Gene Ontology BP GO:0051447 0.544360115305828 0.593603847320839 4290 3399.18181818182 3171 0.068965847691723 2322 0.900100141842308 0.984117543112138 1 0.686377369695291 4287 2322 3047 4134 3732 3073 4285 2682 3171 3145 3513 3629 M13544 GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. 43/62 Gene Ontology BP GO:0000381 0.436125531839811 0.486174436907197 1875 3057.54545454545 3171 0.050750841196411 1225 0.813317216282478 0.549681572459431 1 0.860270897317887 1873 3749 3913 3171 2498 2802 2265 3872 1225 4097 4168 3630 M12586 GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 11/20 Gene Ontology BP GO:0022010 0.0903760747293023 0.122984369271365 1450 3185.45454545455 3172 0.00857430496481817 1447 0.637292174791256 0.637292174791256 1 1.97243452690362 1447 4575 2278 4516 3680 3172 2383 1545 4566 4514 2364 3631 M13708 GO_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. 547/698 Gene Ontology BP GO:0070925 0.165970030972905 0.206928873021685 3175 2954.36363636364 3172 0.0179849003481838 1349 1.04376908930907 -1.1329690655587 -1 2.43089236182348 3172 2940 4445 1967 4174 2126 3690 3396 1349 3831 1408 3632 M10707 GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 9. 31/53 Gene Ontology BP GO:0034162 0.0281870883277845 0.0470087892434341 2180 3014.36363636364 3173 0.00259589489083013 992 0.935983236320673 1.04342050360673 1 4.23846707266184 2178 3450 2545 3173 3636 3754 2853 992 3937 3517 3123 3633 M12986 GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM.html The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 11/20 Gene Ontology BP GO:0032291 0.0496548516872799 0.0741760373321922 1450 3162.54545454545 3173 0.00461930226779139 1269 0.637292174791256 0.637292174791256 1 2.45088415716394 1448 4576 2279 4517 3681 3173 2384 1269 4567 4529 2365 3634 M12604 GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER.html The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. 18/41 Gene Ontology BP GO:0060795 0.0973218575268429 0.130802600540843 4140 3127.27272727273 3175 0.0092649245855863 1597 1.09984043224198 -0.897950152130033 -1 3.31112166153122 4140 3175 2456 2077 2660 3727 4447 1597 3506 2646 3969 3635 M14758 GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. 35/55 Gene Ontology BP GO:0060338 0.00353833034623974 0.00990604759389502 3485 2710.36363636364 3175 0.000322184909357938 636 1.04905025798794 -1.17865974048898 -1 7.17733631194034 3483 3422 3261 3175 636 3186 4592 1604 877 2674 2904 3636 M13355 GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 47/57 Gene Ontology BP GO:0090199 0.0539713606082369 0.0795970652646994 2055 2896.72727272727 3176 0.00503115894396413 600 0.678901796371668 -0.672007358427416 -1 2.54049755174546 2054 4398 3740 4467 3176 600 1913 1440 4426 4241 1409 3637 M10224 GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of cell cycle checkpoint. 40/42 Gene Ontology BP GO:1901976 0.0446955053932238 0.0678429048792159 2950 2981.27272727273 3177 0.00414820386188659 1417 0.751465068231326 0.756679874740716 1 2.99145888593208 2950 3396 3862 3785 1417 2507 3177 2729 1669 3573 3729 3638 M14287 GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. 415/631 Gene Ontology BP GO:1901361 0.478458096891737 0.528553068574846 1720 3267.09090909091 3177 0.0574616737770077 1720 1.1150887091941 1.1432634277842 1 1.04504249310943 1720 4628 4127 4489 3177 2629 2087 3081 2410 4258 3332 3639 M11544 GO_PROTEIN_LOCALIZATION_TO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CENTROSOME.html A process in which a protein is transported to, or maintained at, the centrosome. 22/22 Gene Ontology BP GO:0071539 0.0929801363339696 0.12583788134706 2915 2755.27272727273 3178 0.00883266340929372 979 0.881231984835052 -0.807528442173537 -1 2.70150270858666 2913 3497 3598 3540 2302 3178 3472 1656 1377 3796 979 3640 M12131 GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. 18/20 Gene Ontology BP GO:2000647 0.206040946184845 0.249728711278479 4445 3074.18181818182 3178 0.0207564111972138 1183 1.5531996940147 -1.69538715443702 -1 3.1889652513967 4445 3178 1874 3323 4097 4337 3897 3058 1297 1183 3127 3641 M10058 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 38/48 Gene Ontology BP GO:0042992 0.352961216793677 0.40541311817847 1750 2949.81818181818 3179 0.0388042394792783 1748 0.898074160844425 1.01403312299731 1 1.19327464729951 1748 3752 3652 4010 3179 2094 1813 2599 3694 3785 2122 3642 M12092 GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving guanosine-containing compounds (guanosines). 50/59 Gene Ontology BP GO:1901068 0.0712942385417739 0.100674436734787 4330 2921.72727272727 3179 0.00670138276853513 899 1.00697907491017 -0.947379047320821 -1 3.4220954589284 4326 899 3037 1531 1584 3299 4306 3628 3456 2894 3179 3643 M10208 GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION.html The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. 17/25 Gene Ontology BP GO:0021889 0.00326097315497459 0.00932021381455576 3530 2277.63636363636 3181 0.000296892438285944 502 1.35177352223109 1.36590014543628 1 9.37392502512292 3530 1101 630 1408 3784 3191 3181 3266 810 502 3651 3644 M15208 GO__DE_NOVO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_PROTEIN_FOLDING.html The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. 32/33 Gene Ontology BP GO:0006458 0.135237486977943 0.173349869671727 2800 3303.09090909091 3181 0.0131222661256122 1720 0.583454332151831 -0.553594990020952 -1 1.50753236870053 2797 4454 3703 4457 3181 2202 1720 1792 4645 4601 2782 3645 M13737 GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. 4/18 Gene Ontology BP GO:0021892 0.0837503948449705 0.115224892730233 2940 3137.36363636364 3182 0.00870850504831343 1556 1.2595105762753 1.2595105762753 1 4.03050689514879 2936 3949 4447 3585 3182 3556 2186 1556 3486 3027 2601 3646 M10278 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 44/52 Gene Ontology BP GO:0042771 0.160336147138193 0.201012919459148 3690 2806.45454545455 3183 0.015761166848781 920 0.916155182741176 1.10784418423147 1 2.17183931634037 3690 920 3144 1879 3183 2001 1264 3935 3338 3714 3803 3647 M10958 GO_TRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. 174/180 Gene Ontology BP GO:0006399 0.140550360743428 0.179039297872406 2650 3355.54545454545 3184 0.0136750039452652 1899 0.715870904374878 -0.696436580970439 -1 1.81776477927974 2650 4650 4203 4469 1899 2270 3184 3738 2405 4426 3017 3648 M12448 GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 23/29 Gene Ontology BP GO:0060099 0.0163257365264789 0.0302764655471129 4460 2936.36363636364 3184 0.00149528728671913 872 1.64816111832455 1.58178121380143 1 8.54827336286464 4460 1709 872 1569 4399 3260 4572 2206 3184 1677 4392 3649 M14989 GO_LYTIC_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. 63/73 Gene Ontology BP GO:0080171 0.000374508968292189 0.00197796847839223 4450 2666.09090909091 3184 3.40520669688364e-05 126 0.88331728615313 -0.899490147873926 -1 8.15479620539319 4446 126 3184 380 260 3383 4138 3902 2831 3832 2845 3650 M16230 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. 166/197 Gene Ontology BP GO:2001242 0.202304362060382 0.245776030461346 2390 3044.81818181818 3184 0.0203383426974918 2083 0.994100324861723 1.10489520509712 1 2.06075732465454 2387 4302 2967 3345 2083 3623 2739 2360 3186 3317 3184 3651 M11085 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 458/605 Gene Ontology BP GO:1903829 0.659402952709385 0.691390059851284 2560 3204.54545454545 3185 0.0932732183489281 2455 0.98670262449436 1.00945231858221 1 0.530028772001196 2557 3280 3551 3185 4363 2748 2455 3089 2590 4013 3419 3652 M15230 GO_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that modulates the frequency, rate or extent of membrane invagination. 23/29 Gene Ontology BP GO:1905153 0.0163257365264789 0.0302764655471129 4465 2931.63636363636 3185 0.00149528728671913 873 1.64816111832455 1.58178121380143 1 8.54827336286464 4461 1710 873 1570 4400 3261 4573 2140 3185 1682 4393 3653 M16410 GO_LYSOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. 63/73 Gene Ontology BP GO:0007040 0.000374508968292189 0.00197796847839223 4450 2675.72727272727 3185 3.40520669688364e-05 127 0.88331728615313 -0.899490147873926 -1 8.15479620539319 4447 127 3185 381 261 3384 4139 3998 2832 3833 2846 3654 M10598 GO_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_PROTEIN_TRANSPORT.html The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. 832/1034 Gene Ontology BP GO:0006886 0.268958030703339 0.318033473154418 3445 3242.81818181818 3186 0.0308427899084291 1748 0.839762511859639 -0.824000326424199 -1 1.41778942613532 3441 3618 4250 3186 3068 2189 3923 3118 2700 4430 1748 3655 M13106 GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION.html Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. 18/20 Gene Ontology BP GO:0000394 0.160361048147939 0.201012919459148 3435 2916.54545454545 3187 0.0157638203858941 129 0.865159796796372 -0.575106547129179 -1 2.05035603860292 3435 3187 3706 1917 1965 2906 2874 4138 129 4002 3823 3656 M16222 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 35/35 Gene Ontology BP GO:0090503 0.00998209255054086 0.0206246343861752 4570 3297.72727272727 3187 0.000911606750625219 905 0.734460501006482 -0.636720456182899 -1 4.22205126240912 4568 3095 4074 3181 905 2781 3187 4192 1764 4246 4282 3657 M10644 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process. 220/244 Gene Ontology BP GO:1903364 0.448293696940057 0.497711899752347 3575 2681.45454545455 3190 0.0526315789473684 410 0.850691483566688 -0.731206372119326 -1 0.870667413059848 3575 676 4060 410 2759 2364 3520 3506 1253 4183 3190 3658 M13643 GO_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 105/151 Gene Ontology BP GO:0007219 0.0102683232327991 0.0211000020689681 3770 2557.90909090909 3192 0.000937869575899943 523 1.25062888011388 -1.13285244293651 -1 7.1544276939224 3768 1461 794 523 3192 3521 3425 4410 2762 840 3441 3659 M12961 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 37/47 Gene Ontology BP GO:1902235 0.00242834094224026 0.00743359895016049 3195 3201.54545454545 3193 0.000221002315752767 557 0.937814023344896 -0.992874470701608 -1 6.814989841303 3193 4076 3032 2948 557 3612 2517 3859 4473 2808 4142 3660 M16224 GO_TRANSCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCYTOSIS.html The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. 11/12 Gene Ontology BP GO:0045056 0.000287508570508654 0.00165977342255182 2365 3006.63636363636 3193 2.61405591497524e-05 219 1.48357524318236 -1.06104741180639 -1 14.0899883311549 2363 3922 2276 3573 219 3554 3783 2634 4451 3105 3193 3661 M16706 GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. 197/236 Gene Ontology BP GO:2001235 0.557900916711948 0.606663464702195 3055 3217.27272727273 3193 0.0715158157324557 2586 0.939400230705933 0.979495205584633 1 0.686456696389778 3053 3292 3411 2883 2670 4089 3193 3133 2586 3653 3427 3662 M13589 GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT.html The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 18/29 Gene Ontology BP GO:0034219 0.0935457955743061 0.126458043813843 4260 2662.36363636364 3195 0.00888887366066956 307 1.62643632093669 -1.74587526813459 -1 4.98314376634469 4258 1136 1247 2486 3773 3195 4281 4105 307 1189 3309 3663 M14109 GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. 151/183 Gene Ontology BP GO:0072331 0.400985586389246 0.45275077249919 4085 3126.63636363636 3195 0.0455195778426385 2021 1.00045748997421 -0.939193111671665 -1 1.1664748327119 4081 2021 3542 2810 3195 3949 2979 3740 2027 3983 2066 3664 M10771 GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 35/41 Gene Ontology BP GO:0043537 0.092243441834283 0.124987983359033 3180 2881.36363636364 3196 0.0087595049345484 919 1.2858538759594 1.34744763651705 1 3.95974529142613 3178 3407 1558 2391 3388 3292 4635 3196 2013 919 3718 3665 M11134 GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. 186/294 Gene Ontology BP GO:0051146 0.0135988481367218 0.0262118642834161 1850 2807 3198 0.00124396739285505 837 1.12393849008962 1.20968098358465 1 6.06655408252106 1846 3974 837 3273 3729 3597 2411 3198 3815 2201 1996 3666 M14705 GO_ACTIVATION_OF_MAPKKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKKK_ACTIVITY.html Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). 12/13 Gene Ontology BP GO:0000185 0.00937181776126894 0.019678279802881 3690 3070.36363636364 3200 0.000855634605506478 791 1.09537412761694 -1.06833719931205 -1 6.37840067407153 3688 3572 3159 3147 891 3040 4619 4403 791 3200 3264 3667 M14299 GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. 16/22 Gene Ontology BP GO:0006577 0.0369860738348904 0.0584764531273344 3815 2861.90909090909 3201 0.00342026534462865 1340 0.689563977189261 -0.936202353050834 -1 2.89628178612306 3815 3201 3554 3051 1340 2378 3346 3467 1554 3915 1860 3668 M14797 GO_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_REACTION.html The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg. 12/28 Gene Ontology BP GO:0007340 0.452439602353657 0.501835868832316 3205 3076.27272727273 3201 0.0532809989998214 1843 1.1326135947261 -1.17835978633699 -1 1.14886605395021 4242 1843 2417 2026 2518 3856 4511 3988 2033 3201 3204 3669 M16171 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 18/20 Gene Ontology BP GO:0090005 0.000630374061021666 0.00288410079246196 3330 2803 3201 5.73231597182648e-05 324 0.763089125712777 0.912268387208331 1 6.61607242450709 3329 1106 3147 2145 324 3201 3405 3025 3573 3601 3977 3670 M10204 GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. 46/70 Gene Ontology BP GO:2000242 0.5858666392107 0.633225893669544 2315 3384.27272727273 3203 0.0770151656251587 1905 1.30595705255252 1.35989967410908 1 0.875377512942543 2314 4387 1905 4541 4518 4372 2814 3203 3389 2962 2822 3671 M10564 GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 15/17 Gene Ontology BP GO:0046130 0.0281751866412579 0.0470057882544901 1850 2816.36363636364 3205 0.00259478443345942 990 1.23466657901796 -1.23466657901796 -1 5.59453178730468 1849 3903 3205 3554 3678 2041 2352 990 3975 3433 2000 3672 M10519 GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 24/54 Gene Ontology BP GO:0030800 0.0224688882930863 0.0389667302376931 3630 2539.81818181818 3206 0.00206379106643197 927 1.64937625861832 -1.40941374863001 -1 7.93659810678027 3627 1046 927 1224 3512 3808 3627 1773 3206 1776 3412 3673 M14480 GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 15/17 Gene Ontology BP GO:0006152 0.0384523773408334 0.0603640053194662 1850 2832.36363636364 3206 0.00355830740548918 1144 1.23466657901796 -1.23466657901796 -1 5.13599019920504 1850 3904 3206 3555 3679 2042 2353 1144 3976 3446 2001 3674 M13455 GO_SPINAL_CORD_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_PATTERNING.html The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. 17/34 Gene Ontology BP GO:0021511 0.110021548031522 0.145022737391125 4395 2641.81818181818 3207 0.0105402425501666 444 1.26075499515823 -0.981570180857497 -1 3.60392921651433 4393 444 1381 645 1787 4461 3449 4599 3207 1480 3214 3675 M14217 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. 15/16 Gene Ontology BP GO:1904814 0.555188192183814 0.603995945342831 3250 2733.36363636364 3207 0.0709993284338907 131 1.16700887052834 -1.42390690997185 -1 0.862998793704399 3247 3207 3560 1684 3429 2462 2256 3534 131 3878 2679 3676 M14311 GO_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PIGMENTATION.html The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. 44/53 Gene Ontology BP GO:0048066 0.351727795077151 0.404295807928355 3210 3202.18181818182 3209 0.0386378122339563 1808 1.05960269353971 1.06233443928761 1 1.41415810151545 3209 3058 2360 3556 4057 1960 1808 4637 4151 3186 3242 3677 M10776 GO_GLUCOCORTICOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. 7/24 Gene Ontology BP GO:0008211 0.00335315342516505 0.00953179429464245 2005 3043.54545454545 3211 0.000335822383337491 372 1.19079083323518 1.19079083323518 1 8.2166248503846 2001 4606 4261 4528 3211 2006 2053 372 4541 3401 2499 3678 M11426 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. 75/88 Gene Ontology BP GO:1903363 0.0908976255905358 0.123452029151419 3215 2819.72727272727 3212 0.00862599603110121 823 0.908889314854047 -0.913916966824609 -1 2.81245630397452 3212 3339 4038 2727 1700 3309 3433 2255 823 4067 2114 3679 M13435 GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response. 13/29 Gene Ontology BP GO:0002739 0.255208571075409 0.303860153841831 3780 2831.18181818182 3212 0.0264308848084685 775 1.63979765990142 1.63611190930554 1 2.88966577659751 3777 3234 2107 3362 3212 3709 4548 2134 775 1500 2785 3680 M14373 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 195/240 Gene Ontology BP GO:0043242 0.415430021217133 0.467020026268016 3285 2930.54545454545 3212 0.0476352358098828 1216 1.07154963904204 -1.18725201930853 -1 1.20075039711185 3283 3637 3549 1565 4480 2551 4011 3212 1216 2629 2103 3681 M10830 GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mitochondrial DNA. 18/18 Gene Ontology BP GO:0032042 0.0301429841121933 0.0493682876008572 4110 3204.18181818182 3213 0.00277855307883262 1272 0.942098742635792 -0.811306895197835 -1 4.19772279715745 4109 3182 3213 2798 1272 3730 3612 3971 2105 3140 4114 3682 M11856 GO_REGULATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 296/473 Gene Ontology BP GO:0042391 5.96634041312039e-08 1.56843965775419e-06 4035 2716.81818181818 3213 5.4239459772054e-09 132 1.29107932473324 -1.33842492853384 -1 25.6113101303619 4032 1943 132 2739 3378 3213 4050 4484 2134 518 3262 3683 M12553 GO_EPITHELIAL_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. 38/60 Gene Ontology BP GO:0003351 0.030428450196167 0.0497482708231782 3605 3097.09090909091 3213 0.00280524032993415 1030 1.20022884179839 -1.22090364038482 -1 5.33713387603124 3603 3401 2036 3213 2752 3978 3765 1030 2988 2863 4439 3684 M10951 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html The directed movement of a protein to a specific location. 1474/1849 Gene Ontology BP GO:0045184 0.488454527727887 0.538445609456967 4530 3506.27272727273 3214 0.0648346119953704 2501 0.916430422395729 -0.876187644460792 -1 0.831731014967643 4528 2934 4270 3158 2623 3214 4161 4174 2501 4414 2592 3685 M13138 GO_POSITIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of exocytosis. 82/117 Gene Ontology BP GO:0045921 0.195140913683232 0.238442928405483 4385 3247 3216 0.0195418128105442 2061 1.04199953964423 -1.07563557576968 -1 2.20743107035464 4382 2098 2772 3065 2061 4202 3632 3505 3716 3216 3068 3686 M11534 GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. 14/17 Gene Ontology BP GO:0072202 0.000661392245712097 0.00297672793066188 3265 2659 3219 6.01446514243861e-05 331 1.29344099175373 1.06882226353192 1 11.1609849320586 3263 3219 1803 3280 331 3794 1891 3790 1844 2215 3819 3687 M10532 GO_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASODILATION.html Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels. 45/71 Gene Ontology BP GO:0042312 0.000933823368706873 0.00377833055182007 2970 2757.90909090909 3220 8.49290890823897e-05 495 1.53233678689248 1.31167333838179 1 12.6818115722107 2970 3384 495 3696 3537 3220 4563 1959 2551 618 3344 3688 M13267 GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. 14/21 Gene Ontology BP GO:0033605 0.0730541034440675 0.102628026343498 3705 2906.54545454545 3221 0.00687264543634202 1228 1.14702963347489 -1.21127899023914 -1 3.8667901869331 3703 3221 2687 3707 1598 1922 3343 4215 1228 3363 2985 3689 M10966 GO_CELLULAR_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 19/27 Gene Ontology BP GO:0071285 0.223449643876322 0.269076395692682 1770 3151.18181818182 3222 0.0227280801227743 1494 1.54750456799926 0.968364133589256 1 3.00577234825836 1768 4530 2838 4407 3792 2165 1494 3995 3540 3222 2912 3690 M14645 GO_LEUKOCYTE_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CELL_CELL_ADHESION.html The attachment of a leukocyte to another cell via adhesion molecules. 255/415 Gene Ontology BP GO:0007159 0.00115615115903326 0.0043843287228865 3225 2827.45454545455 3222 0.000105159926431669 521 1.19450036804697 1.20957963647002 1 9.61964910948562 3222 2499 521 2059 3519 3315 3058 3805 3411 1226 4467 3691 M14830 GO_CELLULAR_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a cell. 7/16 Gene Ontology BP GO:0009992 0.00683499863948517 0.0153194839448577 3480 2738.81818181818 3223 0.00068561128396742 563 0.74236155842676 -0.64338344509839 -1 4.59536024103915 3476 1248 4519 563 828 4170 1458 3223 3942 2595 4105 3692 M15342 GO_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_GROWTH.html Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 53/75 Gene Ontology BP GO:0060420 0.664532908737845 0.691390059851284 2730 3227.63636363636 3225 0.0945233284889286 2001 1.1170940436159 1.18620569841623 1 0.601480424570748 3225 2640 2001 2726 4232 3835 3327 4203 2925 2726 3664 3693 M10055 GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION.html The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. 19/24 Gene Ontology BP GO:0021801 0.68618940391 0.691390059851284 2900 3255.45454545455 3226 0.1 1891 1.29498226869276 1.59429618864499 1 0.698959290435056 2896 3852 3307 3872 3226 2738 3071 3827 1891 3221 3909 3694 M14959 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 90/103 Gene Ontology BP GO:0043620 0.021081328005152 0.0369877146334738 455 2262.36363636364 3226 0.00193509913408929 320 1.01314304558212 1.06053197561411 1 4.94941821185251 454 3329 3226 3878 4036 320 411 1098 3903 3272 959 3695 M15755 GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. 22/24 Gene Ontology BP GO:1904666 0.174556482226838 0.216138062300683 3435 2899.36363636364 3226 0.0172883066981712 1851 0.700991198998283 0.643918666775125 1 1.58375495086442 3433 2276 3681 2840 2011 1851 3569 3226 1865 3799 3342 3696 M12702 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 19/37 Gene Ontology BP GO:0090281 0.00106164967426612 0.0041476540170951 3315 2961 3229 9.65602126226522e-05 407 0.797797708392264 -0.768719253489853 -1 6.48708672537238 3311 1728 2905 2858 407 3294 4373 2710 3870 3229 3886 3697 M10136 GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 239/337 Gene Ontology BP GO:0046394 0.000176220748195989 0.0011404746855641 4350 2657.45454545455 3230 1.60213513746322e-05 381 1.24510061111622 1.1843989162058 1 12.5171278704375 4348 670 381 926 3230 4011 4435 4149 2459 432 4191 3698 M12797 GO_TELENCEPHALON_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_GLIAL_CELL_MIGRATION.html The orderly movement of glial cells through the telencephalon. 19/24 Gene Ontology BP GO:0022030 0.68618940391 0.691390059851284 3230 3265.72727272727 3230 0.1 1892 1.29498226869276 1.59429618864499 1 0.698959290435056 2897 3853 3308 3873 3227 2739 3072 3922 1892 3230 3910 3699 M11689 GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. 239/337 Gene Ontology BP GO:0016053 0.000176220748195989 0.0011404746855641 4350 2664.81818181818 3231 1.60213513746322e-05 382 1.24510061111622 1.1843989162058 1 12.5171278704375 4349 671 382 927 3231 4012 4436 4220 2460 433 4192 3700 M12271 GO_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOSIS_I.html The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. 70/204 Gene Ontology BP GO:0007127 0.397930984146133 0.449738369985902 2425 3335.72727272727 3231 0.0450781220947838 1774 0.788100494263589 -0.844362691314853 -1 0.924427719912164 2424 3345 3885 3183 4515 1774 2933 3231 4309 4184 2910 3701 M15860 GO_REGULATION_OF_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PERMEABILITY.html Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. 93/113 Gene Ontology BP GO:0090559 0.0471043801629254 0.0709080171135852 3270 3095 3231 0.00437674938475596 1439 0.827151502290034 -0.759837113108287 -1 3.23955643021419 3270 2999 3516 2934 1439 2186 3231 3342 3821 4221 3086 3702 M11515 GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein oligomerization. 20/25 Gene Ontology BP GO:0032461 0.000735857647727531 0.00319994919147309 4450 2958.54545454545 3232 6.691853575114e-05 349 1.32441673278641 -0.841446326676666 -1 11.2863266139851 4449 3826 1561 3212 349 4489 3232 2583 2282 3321 3240 3703 M13150 GO_TETRAHYDROFOLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. 19/20 Gene Ontology BP GO:0046653 0.61826878306364 0.664389064109726 3095 3283 3232 0.0838259835461072 1020 1.24624749784853 -1.14838376884803 -1 0.745969279669494 3094 4510 3117 3513 4592 2365 2390 4384 1020 3232 3896 3704 M13274 GO_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. 19/19 Gene Ontology BP GO:0046931 0.0067592860483495 0.0151790337755648 4340 2614.27272727273 3233 0.000616376642394107 231 0.960177556936069 -0.632499407543588 -1 5.95994275615678 4340 1084 3243 1359 808 4073 3882 2199 231 3233 4305 3705 M14155 GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. 83/102 Gene Ontology BP GO:0035305 0.576299290603362 0.62404482177739 3385 3155.36363636364 3233 0.0750967828071064 1969 0.993046878338158 -1.10190668390118 -1 0.684615519444368 3383 2096 3454 2567 4627 2966 3233 2721 1969 3459 4234 3706 M14206 GO_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTION_POTENTIAL.html A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. 71/148 Gene Ontology BP GO:0001508 0.0854860117768701 0.117266041508778 4340 2983.18181818182 3235 0.00809095560735606 1409 1.03050240703534 -1.19199391506063 -1 3.26886072704749 1862 3699 1409 4337 1671 4338 2961 3235 4090 3669 1544 3707 M14771 GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a steroid hormone binding to a receptor. 122/224 Gene Ontology BP GO:0043401 0.68618940391 0.691390059851284 3035 3162.45454545455 3235 0.1 2091 1.09736859811485 -1.14408965307711 -1 0.590671310840595 3035 2554 3235 2091 4554 2680 3430 4523 2112 3315 3258 3708 M14788 GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 22/27 Gene Ontology BP GO:0090322 0.0290467383812877 0.0480805669470408 2780 2909.36363636364 3235 0.0026761351239522 1251 1.08794697226681 1.17075289267515 1 4.89192730381865 2779 4161 2192 3602 1251 4523 3235 1705 3706 1552 3297 3709 M11937 GO_CYTOCHROME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 26/27 Gene Ontology BP GO:0017004 0.181502426594938 0.223776044235889 2410 3029.54545454545 3236 0.0180429544148007 1203 0.695931773400991 -0.687008719875137 -1 1.53636096726458 2406 4142 3769 3945 2342 1203 2062 3392 3236 4156 2672 3710 M13916 GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. 19/24 Gene Ontology BP GO:0055098 0.00620843517844692 0.0142103500495459 4290 3060.09090909091 3237 0.000566002274133476 792 1.32621826106913 -1.37559838232783 -1 8.36592683715885 4289 2812 1915 1627 792 4298 3909 1767 4406 3237 4609 3711 M10123 GO_SINGLE_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_FERTILIZATION.html The union of male and female gametes to form a zygote. 76/166 Gene Ontology BP GO:0007338 0.428408364816091 0.479640067730815 3260 3206.18181818182 3238 0.0495770892916123 2487 1.1545332520208 -1.07976815760838 -1 1.24885599627078 3258 3014 2799 2882 4129 3346 3820 2487 3238 3451 2844 3712 M10343 GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. 66/89 Gene Ontology BP GO:1904035 0.0399764030732802 0.0621874771619748 2410 2995.90909090909 3238 0.00370198657001956 1042 1.37637843851865 1.38567101142937 1 5.66588830694057 2409 4038 1042 4033 2095 4109 3238 2614 4131 1169 4077 3713 M11232 GO_REGULATION_OF_RUFFLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RUFFLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of ruffle assembly. 27/35 Gene Ontology BP GO:1900027 0.121904177868215 0.158662976117708 4090 3314.90909090909 3239 0.011748581376788 1344 1.08857326501051 -1.18930597847839 -1 2.96498697205012 4088 3795 3171 3114 4529 4627 3888 1735 1344 2934 3239 3714 M16045 GO_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 1290/1589 Gene Ontology BP GO:0033043 0.445855378881217 0.495714475014171 4355 3421.18181818182 3239 0.057324299810922 2169 0.990351536392947 -0.991839434117168 -1 1.02127080950425 4353 2936 4589 2169 4089 3239 4557 2567 2450 4120 2564 3715 M11499 GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that activates or increases the frequency, rate or extent of membrane depolarization. 15/17 Gene Ontology BP GO:1904181 0.0437191149502512 0.0667624029745713 3635 2789.81818181818 3240 0.00405571657383095 993 1.92408840231556 -1.57798353285236 -1 7.72198567885993 3635 3550 1061 3240 3793 2146 2345 3929 993 1760 4236 3716 M10459 GO_POSITIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEMOPOIESIS.html Any process that activates or increases the frequency, rate or extent of hemopoiesis. 162/254 Gene Ontology BP GO:1903708 0.0979645797246739 0.131552435630276 2720 2964.09090909091 3241 0.00932907446204966 1102 1.16276277683709 1.18240151337351 1 3.49129332620324 2718 4304 1257 3079 3450 3970 3241 1812 3600 1102 4072 3717 M10574 GO_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_PROCESS.html Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. 1774/2967 Gene Ontology BP GO:0002376 2.65805137580124e-08 7.72994565725198e-07 2895 2947.18181818182 3243 2.6580514075948e-09 63 1.18461896622343 1.21344134537748 1 24.7431389158233 2891 1873 4247 1698 3384 4236 3243 3726 2513 63 4545 3718 M10749 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. 24/29 Gene Ontology BP GO:0051150 0.22720730419691 0.272965552912012 2345 3253.72727272727 3243 0.0231589317728999 1506 1.3277290644548 -0.975584982093195 -1 2.54908950635479 2343 3804 1506 4021 4617 3752 2538 3243 4115 2683 3169 3719 M14580 GO_REGULATION_OF_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_FUSION.html Any process that modulates the frequency, rate or extent of myoblast fusion. 15/24 Gene Ontology BP GO:1901739 0.0461321528979489 0.0696925024136871 4325 3095.45454545455 3243 0.00428444475533728 1099 1.17946903812457 -1.10403721219893 -1 4.65423873741992 4321 3204 2251 3243 1432 3703 4102 4391 1099 2916 3388 3720 M16008 GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of ARF protein signal transduction. 14/16 Gene Ontology BP GO:0032012 0.0201156563622261 0.0357244843715412 3635 2676.27272727273 3245 0.00184563389905145 321 1.10698696809057 -1.09863855780051 -1 5.46597065407012 3634 4203 3459 3502 1171 3245 4498 870 321 2802 1734 3721 M16043 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 77/151 Gene Ontology BP GO:0032729 0.0499574769489142 0.0745516806424945 2705 2957.90909090909 3245 0.00464812155368755 1271 1.10570168365879 1.18349264307832 1 4.25182686066692 2703 3685 2061 3625 3245 3617 3013 1271 3513 2272 3532 3722 M16526 GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 8/17 Gene Ontology BP GO:0043950 0.0626015163155975 0.0899582629451745 3665 2856.81818181818 3249 0.0064438300122488 312 2.81416996697937 -2.81416996697937 -1 10.0530301915488 3662 3600 4631 3249 1861 4335 3413 1424 312 2755 2183 3723 M13520 GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of lymphocyte differentiation. 129/229 Gene Ontology BP GO:0045619 0.017589487812576 0.0320956418791829 4290 3119.63636363636 3251 0.00161197402015352 843 1.17692916666343 -1.14099408396422 -1 5.99918754359532 4290 3988 1545 3931 1076 4315 3227 4640 3210 843 3251 3724 M14659 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. 18/28 Gene Ontology BP GO:2000679 0.114593189342727 0.150197777468088 2975 3242.54545454545 3253 0.0110033846739717 1483 0.858890176131104 -0.915343350665836 -1 2.40706513931645 2971 4537 3253 4591 4220 2083 2710 1692 4529 3599 1483 3725 M13548 GO_BLASTOCYST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_DEVELOPMENT.html The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. 54/76 Gene Ontology BP GO:0001824 0.00862716812625612 0.0183969813434783 3255 2834.27272727273 3254 0.000787380541317699 779 0.846705397094313 -0.894615278195058 -1 5.01262039107395 3254 878 3726 2824 870 3708 2541 4272 779 3804 4521 3726 M14122 GO_PROTEIN_K48_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. 20/28 Gene Ontology BP GO:0071108 0.394845915607813 0.44668564194582 2290 3283.72727272727 3255 0.0446343251807226 1909 0.680291656011796 0.801217998686206 1 0.803391109576725 2286 2802 3632 3136 3828 3161 1909 3438 4623 4051 3255 3727 M12141 GO_REGULATION_OF_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of bone development. 13/31 Gene Ontology BP GO:1903010 0.0526334134613638 0.0778706749875122 4605 3233.36363636364 3256 0.00490331727180482 1472 1.50221144134326 -1.25592445228172 -1 5.68322061603473 4604 3230 1976 3302 1472 3256 2988 3809 4456 2098 4376 3728 M15559 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 41/54 Gene Ontology BP GO:1901030 0.00516017204855745 0.0129156969026024 2780 3059.09090909091 3256 0.000470210481380194 743 0.727891434738973 -0.708592463276253 -1 4.69005192246805 2777 3742 3463 3143 743 1935 3256 3542 3894 4285 2870 3729 M12126 GO_MELANIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. 9/18 Gene Ontology BP GO:0006582 0.048707870790551 0.0729207602279388 4620 2965.81818181818 3257 0.00498096191464886 124 1.53198390044918 -1.55061804375138 -1 5.94546386403924 4619 3257 4345 2582 1478 4207 1674 3516 124 2875 3947 3730 M10141 GO_DENTATE_GYRUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENTATE_GYRUS_DEVELOPMENT.html The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. 9/19 Gene Ontology BP GO:0021542 0.0014281415054775 0.00514728305576051 4490 3018.09090909091 3258 0.00014290601511637 468 0.906643074144953 -0.777007872576544 -1 7.08290744284421 4489 3258 4227 3293 468 3906 3761 2249 2946 2873 1729 3731 M15557 GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. 23/31 Gene Ontology BP GO:2001026 0.00632172405774436 0.0144403446444205 4080 2923.09090909091 3258 0.000576360274277483 798 1.21716667613927 1.32878726419501 1 7.64812425194101 4080 3141 1051 3784 798 3258 4370 1866 3791 1684 4331 3732 M13196 GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of the same species. 41/65 Gene Ontology BP GO:0051703 0.0052107335738033 0.0130002913238106 3380 2808.18181818182 3259 0.000474828759602523 132 1.39214898894105 -1.62957670049885 -1 8.96632485424127 3378 4069 2318 3124 3507 2136 4590 1024 3259 3353 132 3733 M14120 GO_SOCIAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOCIAL_BEHAVIOR.html Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. 41/65 Gene Ontology BP GO:0035176 0.0052107335738033 0.0130002913238106 3380 2780.90909090909 3260 0.000474828759602523 133 1.39214898894105 -1.62957670049885 -1 8.96632485424127 3379 4070 2319 3125 3508 2137 4591 714 3260 3354 133 3734 M15416 GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 9/21 Gene Ontology BP GO:0009074 0.0305853853825338 0.0499521931151035 4030 3206.18181818182 3260 0.00310146845339841 1091 2.05183918852861 -2.89990617497491 -1 9.11914649701314 4027 3260 4555 2604 4584 3269 3543 1091 2708 2887 2740 3735 M15110 GO_CATECHOLAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_TRANSPORT.html The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 9/17 Gene Ontology BP GO:0051937 0.0957215620001252 0.128982993967053 3500 3163.90909090909 3261 0.0100113454183702 1768 0.599379141933643 -0.599379141933643 -1 1.81207485052084 3499 3261 4535 3572 1768 1916 2494 2284 4530 4595 2349 3736 M10227 GO_POSITIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA replication. 91/115 Gene Ontology BP GO:0045740 0.126113479600479 0.163228378464821 3265 3120.63636363636 3264 0.0121801909526919 1138 1.1022358437715 1.14266677679182 1 2.95590605080992 3264 4000 3418 4282 3992 3205 1927 1752 1138 3084 4265 3737 M11871 GO_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROAUTOPHAGY.html The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. 304/417 Gene Ontology BP GO:0016236 0.198806723964682 0.24241291577769 4610 3222.18181818182 3264 0.0199486187765722 1254 1.05342060674215 -1.05930472541358 -1 2.20591486951694 4610 2952 3264 2025 3783 1254 3947 3908 2581 3940 3180 3738 M16520 GO_ENDODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the endoderm. 7/16 Gene Ontology BP GO:0001711 0.637499428127546 0.68237516426903 3115 3036.54545454545 3265 0.0964943565055224 414 0.735489178930967 0.565307721899553 1 0.406702296036333 3114 3265 4629 1154 4052 3009 2490 3293 414 3406 4576 3739 M15561 GO_PEPTIDYL_LYSINE_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_TRIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. 26/28 Gene Ontology BP GO:0018023 0.0523229041537338 0.0775382009965691 3870 3276.36363636364 3266 0.00487367138407478 1471 1.38211146318088 -2.01039618958382 -1 5.2367823294723 3870 3803 2785 3266 1471 4549 4125 2991 3379 2847 2954 3740 M11805 GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE.html An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. 17/108 Gene Ontology BP GO:0002251 0.00593037557533078 0.0137253094429656 3270 2792.90909090909 3269 0.000540583839671969 711 2.09135259194955 -2.07509722909552 -1 13.3064719952228 3269 3865 711 3472 1812 2170 3319 4555 3005 1046 3498 3741 M16497 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 692/874 Gene Ontology BP GO:0031400 0.6513215599 0.691390059851284 4160 3264.09090909091 3270 0.1 1313 1.009597899946 -0.962231558928746 -1 0.542574883379352 4156 1313 4626 2409 3275 3270 4101 4406 2857 2520 2972 3742 M10234 GO_NUCLEOTIDE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. 52/76 Gene Ontology BP GO:0046939 0.0569558766028512 0.0833644837474259 3525 2706.63636363636 3271 0.00531692457965736 1229 0.919514471333959 -0.816798664982177 -1 3.3815263401977 3521 3042 3538 3479 1500 1229 1504 3640 1328 3271 3721 3743 M10383 GO_EPIDERMIS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_MORPHOGENESIS.html The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 39/52 Gene Ontology BP GO:0048730 0.00101751935726304 0.00402937665476165 3275 2703.18181818182 3272 9.25445703519278e-05 503 1.80609866770672 -2.00433254905118 -1 14.7768888146445 3272 2677 503 3307 685 3929 4218 3646 3562 903 3033 3744 M13481 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE.html The directed movement of a protein to a specific location in a membrane. 317/432 Gene Ontology BP GO:0090150 0.135028464076938 0.173225101557759 1560 3220 3272 0.0131005830956144 1146 0.845953319222333 -0.849866447831184 -1 2.19148024639183 1558 4287 4169 4296 4351 1778 1146 2965 3272 4389 3209 3745 M15726 GO_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. 159/292 Gene Ontology BP GO:0006338 0.385427099448895 0.437412754569685 2730 3276.72727272727 3273 0.0432920109826305 2035 1.02041620269699 -1.1035887360571 -1 1.24217699330869 2728 4305 3838 4226 3705 2791 3662 2976 2505 3273 2035 3746 M10108 GO_MULTICELLULAR_ORGANISM_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_AGING.html An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). 30/39 Gene Ontology BP GO:0010259 0.220269314636286 0.265590339726001 4090 3313.45454545455 3274 0.0223649033417433 2125 1.11769563674411 -1.07033154129249 -1 2.18961941041235 4087 3112 2719 2382 2125 4467 4504 3487 3274 3468 2823 3747 M12755 GO_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE.html An immune response mediated through a body fluid. 112/484 Gene Ontology BP GO:0006959 1.40553496271870e-10 7.69406374297657e-09 4240 2732 3275 1.27775905709863e-11 60 1.68560963855196 -1.71602986163774 -1 46.7495079926523 4239 3664 60 2970 874 4404 3689 3275 2379 174 4324 3748 M16166 GO_EPOXYGENASE_P450_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPOXYGENASE_P450_PATHWAY.html The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. 9/57 Gene Ontology BP GO:0019373 0.296727937595271 0.348127860219566 4535 3252.45454545455 3275 0.0345887918805308 1859 1.03875316405295 -1.01109919859077 -1 1.61682559246352 4533 1859 4600 2558 2309 3826 3375 2373 4179 2890 3275 3749 M11291 GO_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. 15/27 Gene Ontology BP GO:0055075 0.244573270700764 0.292319401122696 3965 3367.63636363636 3276 0.025175182648714 1534 1.18110134519625 -1.26539132829486 -1 2.14626999904382 3962 3893 1534 4502 4519 2939 2002 3276 3147 2906 4364 3750 M16241 GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX.html The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. 13/13 Gene Ontology BP GO:0016558 0.349838965178891 0.402323456494656 2355 3108.09090909091 3276 0.038383506992301 2331 0.532129519169938 -0.540480891460957 -1 0.708742348201757 3472 2355 3812 2438 2352 2331 3276 2537 3629 4629 3358 3751 M16967 GO_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 21/40 Gene Ontology BP GO:0071731 0.100579408627577 0.134442972807847 3005 3172.09090909091 3276 0.00959048876245731 1616 0.808774846765266 0.835635985888877 1 2.39906764992278 3005 3498 2577 4026 2136 3276 3751 1616 4438 4080 2490 3752 M11272 GO_RRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. 279/371 Gene Ontology BP GO:0016072 0.247668900429655 0.295488049666458 690 3276.90909090909 3277 0.0255390146173335 687 0.665498289908894 0.636562020745813 1 1.19401970477107 687 4641 4207 4647 3120 2391 1554 2709 4346 4467 3277 3753 M15325 GO_COENZYME_A_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 11/11 Gene Ontology BP GO:0015937 0.0145043003376122 0.0275575783874681 4650 2966.45454545455 3277 0.00132734702271126 1018 0.697322278692713 -0.541473179540929 -1 3.70797132929898 4649 1219 3277 2369 1018 4214 4019 2337 1230 3680 4619 3754 M11801 GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle. 29/37 Gene Ontology BP GO:1900087 0.0208657226558 0.0367205910559291 3280 2991.63636363636 3280 0.00191511729107264 1146 0.884881506703057 -0.967817649095335 -1 4.3310069155072 3280 3452 3787 3157 1146 4178 4608 2055 1591 4191 1463 3755 M11569 GO_SARCOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOMERE_ORGANIZATION.html The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. 35/61 Gene Ontology BP GO:0045214 0.403149592493688 0.45475274033288 2650 3064.27272727273 3282 0.0458335634622035 1702 1.1727528935048 1.0964899254749 1 1.36151462514261 2647 4099 1702 3390 3696 3282 2590 2912 3987 1914 3488 3756 M13975 GO_MUSCLE_ATROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ATROPHY.html A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. 11/18 Gene Ontology BP GO:0014889 0.0372103045093627 0.058791017617 3480 3038 3282 0.00344136268896655 1234 1.20208580864575 -1.29514317430704 -1 5.0473068518554 3479 3249 2557 3282 1342 3582 3930 3629 2503 1234 4631 3757 M10491 GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. 297/367 Gene Ontology BP GO:0032886 0.390851603051689 0.442489661557058 3410 3202.90909090909 3284 0.0440627760746862 1433 0.987206912350286 -1.08799765926482 -1 1.18448803060996 3410 3284 3980 2677 4354 3194 4419 2420 1433 3996 2065 3758 M10799 GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. 60/65 Gene Ontology BP GO:1901185 0.0148372208796688 0.0280754732627487 3895 3001.36363636364 3284 0.00135802191378143 1022 1.03073952773906 -0.77540369315149 -1 5.45750121101249 3892 3031 3461 1674 1022 3284 3536 4516 1221 3065 4313 3759 M10572 GO_PROTEIN_HOMOTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTETRAMERIZATION.html The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. 72/87 Gene Ontology BP GO:0051289 0.000607180254335377 0.00280278742403027 4125 2869.72727272727 3285 5.52134450376299e-05 319 0.943262493983219 -0.95627223379621 -1 8.220769237782 4123 2109 3285 1782 319 2661 4202 4514 1128 4019 3425 3760 M13633 GO_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIVISION.html Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. 289/381 Gene Ontology BP GO:0051302 0.529937595058448 0.579370213770432 3535 3311.18181818182 3285 0.0663245144135607 1761 1.10516755414695 -1.07454456956331 -1 0.885009701524852 3531 3285 2964 3760 4385 3489 4404 2658 1761 3172 3014 3761 M15384 GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. 26/37 Gene Ontology BP GO:0099601 0.0032341727316581 0.00926068044332624 4140 2782.09090909091 3285 0.000294448820712349 628 1.60082107340115 -1.65411119660219 -1 11.1181508176607 4138 3797 628 2072 3510 4286 3867 2827 3285 1178 1015 3762 M11275 GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper cell differentiation. 15/40 Gene Ontology BP GO:0045622 0.00965707956768429 0.0200689554392296 3650 3153.27272727273 3286 0.000881793859786412 899 1.51037874441302 -1.79491069126606 -1 8.75493886657471 3648 4540 2511 3549 899 4394 3575 3286 2118 2905 3261 3763 M13899 GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. 145/173 Gene Ontology BP GO:0006367 0.163356890885155 0.204163205288377 3290 2892.63636363636 3286 0.0160835909284034 520 1.00448119198422 -1.02384945314206 -1 2.35905977420525 3286 3648 3970 2654 4556 1257 2547 4243 520 3792 1346 3764 M12688 GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. 7/16 Gene Ontology BP GO:2001053 0.117872520651791 0.153889124184282 4145 3071.90909090909 3287 0.0124635484253138 1715 1.56746546820953 -1.65224777331495 -1 4.34515659181406 4142 2917 4382 2680 1853 3485 4117 3287 1715 1807 3406 3765 M12758 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of cellular response to hypoxia. 15/15 Gene Ontology BP GO:1900037 0.0828845288187994 0.114236289275437 3290 3279.72727272727 3287 0.00783477344030921 890 1.0605411243421 -0.884564257939543 -1 3.40567773951479 3287 4558 3260 4587 3794 1433 890 4577 4012 2909 2770 3766 M13338 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleotide across a membrane. 13/13 Gene Ontology BP GO:1901679 0.190943867298107 0.234175491443883 3895 3104.54545454545 3287 0.0190781170813962 1548 0.945752263823894 -0.903170693976884 -1 2.02791065784953 3891 4217 3400 3924 2047 2373 3277 2820 1548 3287 3366 3767 M16674 GO_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_ASSEMBLY.html The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 21/22 Gene Ontology BP GO:0046847 0.546688977828024 0.595724546565292 3540 3342.90909090909 3289 0.0693994645360678 2294 0.995215680113403 -0.786242022090284 -1 0.754765221001571 3538 2294 3081 2606 4588 3735 3894 2685 3289 2932 4130 3768 M14368 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex assembly. 219/268 Gene Ontology BP GO:0031334 0.68618940391 0.691390059851284 4405 3440.45454545455 3290 0.1 2544 1.02208660040486 -1.02972340871283 -1 0.5494184187304 4402 3290 3161 3344 3137 3198 4618 3838 2544 3495 2818 3769 M14450 GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. 13/23 Gene Ontology BP GO:0042402 0.592497669692656 0.639353352755085 4315 3500.54545454545 3290 0.0783685601962416 2720 1.45703847807977 0.976082579114727 1 0.957046096432832 4311 4235 2720 3999 3052 3327 3173 2741 4447 3290 3211 3770 M16505 GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 33/41 Gene Ontology BP GO:0043536 0.63912246370824 0.683955111231472 4195 3192.63636363636 3291 0.0884930460035467 1638 0.778011681973447 -0.632113628930085 -1 0.428160714934031 4195 1638 2661 1945 2807 2949 3853 3833 3291 3587 4360 3771 M14119 GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a virus effects a change in the structure or processes of its host organism. 41/58 Gene Ontology BP GO:0019048 0.550353293048783 0.59943676792041 3000 3104.27272727273 3292 0.0700858501749109 743 1.09483343467262 1.32816511329079 1 0.821283340173616 2998 4068 3693 2947 4022 3626 2241 3292 743 3042 3475 3772 M15199 GO_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 13/23 Gene Ontology BP GO:0009310 0.560994776993673 0.609458019461023 4315 3498 3292 0.072108397593316 2702 1.45703847807977 0.976082579114727 1 1.06064789178183 4312 4236 2721 4000 3053 3328 3174 2702 4448 3292 3212 3773 M15436 GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. 18/22 Gene Ontology BP GO:0044320 0.000427506120818626 0.00217873601332866 4615 3030.36363636364 3293 3.88717469842943e-05 276 1.12078449088742 -1.1047717239756 -1 10.1890795280182 4614 1110 2258 2657 276 4650 4094 3304 3293 2654 4424 3774 M10494 GO_ENDOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. 72/73 Gene Ontology BP GO:0007032 0.0238855559206289 0.0410108825456406 4390 2867.81818181818 3295 0.00219535405622808 857 0.803428113765856 -0.794011659286513 -1 3.79953478533776 4388 3692 4101 3142 1185 3295 3948 1535 857 4198 1205 3775 M12342 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that increases the frequency, rate or extent of cardiac muscle contraction. 10/16 Gene Ontology BP GO:0060452 0.0266385689569189 0.0448766333658739 3545 2887.45454545455 3296 0.00245151786392673 531 1.77054178668784 -1.99614083262143 -1 8.14918321666875 3545 2911 1374 2116 4287 4515 3296 4056 531 669 4462 3776 M10886 GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 172/209 Gene Ontology BP GO:0031330 0.266839299838852 0.316009992911728 3860 3214.18181818182 3297 0.0278229159695637 1849 0.914390042729175 -0.90453984301217 -1 1.55339830831182 3859 2969 3922 2723 2213 3404 4567 3297 2575 3978 1849 3777 M10990 GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. 6/12 Gene Ontology BP GO:0090220 0.184447392710148 0.227106038179497 3300 3545.63636363636 3298 0.0201824861124129 2078 0.228520164196654 -0.136006771090419 -1 0.492314775656546 3298 4265 4273 3833 2078 3065 2928 2952 4582 4460 3268 3778 M11456 GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. 171/214 Gene Ontology BP GO:1901293 0.0429611512178905 0.0659294975649223 695 2768.81818181818 3299 0.00398397863541163 522 0.792633070006194 -0.734998649872128 -1 3.18959656595573 692 3299 3944 4308 4508 522 960 2381 3701 4109 2033 3779 M16321 GO_GLUCOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. 33/52 Gene Ontology BP GO:0006007 0.0016749920423654 0.00579891218238557 3865 2906.09090909091 3299 0.000152388061392238 478 1.05175509785463 -0.909058747561396 -1 8.03210904081172 3864 3105 3050 3377 478 2677 3590 4169 1022 3299 3336 3780 M10168 GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of mitosis. 52/63 Gene Ontology BP GO:0045840 0.582277940027117 0.629541780374777 4210 3363.81818181818 3301 0.0762909062711112 2645 1.26010244163515 -1.08588951622922 -1 0.855184474850836 4209 2646 2645 3164 2714 3710 3301 4040 3601 2960 4012 3781 M14164 GO_REGULATION_OF_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTON_TRANSPORT.html Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/21 Gene Ontology BP GO:0010155 0.00502106637998065 0.0126491726399837 4540 3443.81818181818 3301 0.000457505702231761 736 0.586515280651081 -0.524722942698946 -1 3.79520544391975 4540 2887 3301 3371 736 4507 3142 3271 4590 4568 2969 3782 M15741 GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. 165/214 Gene Ontology BP GO:0060759 0.577234714118034 0.624766951568089 3995 3228.27272727273 3301 0.0752826012919472 1672 1.06930263329393 -1.11122403110675 -1 0.736169492186679 3993 3301 2822 2702 3807 2931 4206 4000 3555 1672 2522 3783 M16818 GO_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_CIRCULATION.html Any process that modulates the frequency, rate or extent of blood circulation. 275/435 Gene Ontology BP GO:1903522 4.27695626812448e-14 7.107384826994e-12 2780 2959.09090909091 3301 3.88814206193141e-15 20 1.30760459248816 -1.46006486966439 -1 49.829232203465 2780 1949 20 2748 4155 4636 3568 4641 3301 100 4652 3784 M15079 GO_PROTEIN_K63_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. 44/59 Gene Ontology BP GO:0070534 0.603582831606323 0.649657856919782 2555 3344.63636363636 3302 0.0806764085744212 2360 0.745381986916509 0.682964029758663 1 0.466695668285534 2555 4067 4002 3840 3302 2892 2360 2811 3767 3948 3247 3785 M12431 GO_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MEMBRANE.html A process in which a protein is transported to, or maintained in, a specific location in a membrane. 441/589 Gene Ontology BP GO:0072657 0.194389305348493 0.237731851723907 1910 3068.54545454545 3303 0.0194586127096598 1400 0.965807206990552 -0.980024431851632 -1 2.0495242225628 1910 3624 4037 3451 3303 2183 1400 2828 3029 4235 3754 3786 M13695 GO_HISTONE_H4_K8_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K8_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. 16/16 Gene Ontology BP GO:0043982 0.270244474574237 0.31923014475601 3110 3009.36363636364 3303 0.0282342659909214 355 1.31009595833945 0.884152367028774 1 2.21052987925653 3108 4201 3605 3356 4472 2416 1613 3172 355 3502 3303 3787 M14977 GO_HISTONE_H4_K5_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K5_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. 16/16 Gene Ontology BP GO:0043981 0.270244474574237 0.31923014475601 3110 3007.18181818182 3304 0.0282342659909214 356 1.31009595833945 0.884152367028774 1 2.21052987925653 3109 4202 3606 3357 4473 2417 1614 3137 356 3504 3304 3788 M14525 GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. 41/57 Gene Ontology BP GO:0048635 0.167909910272693 0.209067383596157 3705 3085.90909090909 3305 0.0165715703044329 1366 1.12748576201255 -1.15898712288752 -1 2.60950754628284 3705 4065 1734 3105 3305 2196 4015 3432 4310 2712 1366 3789 M16466 GO_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION.html Long distance growth of a single axon process involved in cellular development. 53/63 Gene Ontology BP GO:0048675 0.20669005445666 0.25038500999397 1800 3240.18181818182 3305 0.0208292191023072 1797 1.09001797077029 1.21832057364247 1 2.23055209001157 1797 4371 2212 4531 2098 3305 2315 4245 4226 3035 3507 3790 M14246 GO_OXALATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALATE_TRANSPORT.html The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. 6/12 Gene Ontology BP GO:0019532 0.00504486193694923 0.0127022416626757 3015 3225.18181818182 3306 0.0005056351448253 467 1.1494727381735 1.1494727381735 1 7.44106239157964 3012 3610 4483 3937 3674 2766 2914 467 4476 3306 2832 3791 M16333 GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. 31/61 Gene Ontology BP GO:0046640 0.412405734701756 0.463956451539475 2635 3355 3309 0.0471883691783909 1813 0.936294147085783 -0.803617319356224 -1 1.05699052201795 2634 4431 2806 3112 3562 1813 3309 4608 4325 2775 3530 3792 M12040 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. 152/246 Gene Ontology BP GO:0070972 0.127801877624545 0.164817665351166 780 3027.63636363636 3310 0.0123538456530658 780 0.71156205236303 0.760026269132164 1 1.89420520856722 780 4318 4188 4113 2068 1652 1107 3310 4434 4418 2916 3793 M10079 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. 46/56 Gene Ontology BP GO:1903573 0.000723972531461231 0.00316304618675034 3880 3192.90909090909 3311 6.5837353183592e-05 346 0.970943024761096 0.989349578615267 1 8.28799471351082 3877 3737 3297 1683 346 3155 2511 4638 3995 3311 4572 3794 M11281 GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. 60/77 Gene Ontology BP GO:1903313 0.0502255431806611 0.0749036706473128 1300 2628.27272727273 3311 0.00467365672215542 863 0.795840369300789 0.811547951441441 1 3.05174268432934 1296 3715 3742 3810 1458 863 882 3311 4254 4179 1401 3795 M14089 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 27/43 Gene Ontology BP GO:0051024 0.13606603854487 0.174203743457432 1520 3285.27272727273 3311 0.013208262980417 1518 0.785861457082775 -0.858078335191668 -1 2.0284784148971 1518 4477 3311 4432 1885 2674 3950 2707 4608 3959 2617 3796 M16225 GO_EPITHELIAL_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MATURATION.html The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 16/25 Gene Ontology BP GO:0002070 0.123150779664965 0.160016916442637 4490 3012.36363636364 3311 0.0118762079219377 796 1.0148619249112 -1.10339851785159 -1 2.75069021824268 4490 2827 3197 3311 2350 4334 3844 3333 796 3507 1147 3797 M12145 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. 26/48 Gene Ontology BP GO:0001916 0.0727473755279975 0.102294813639097 2015 3288.90909090909 3312 0.0068427747044718 1595 0.83265016467161 -0.687432425654149 -1 2.80807321791937 2012 4475 3312 4404 1595 2191 2747 4585 4517 3607 2733 3798 M12496 GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. 46/74 Gene Ontology BP GO:1903307 0.186069736426578 0.2288008677571 4145 3151.09090909091 3312 0.0185423525969458 2037 1.14339741804924 -1.16483143824315 -1 2.49335534826949 4141 2163 2200 2570 2037 4023 4087 3813 3492 3312 2824 3799 M11768 GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 129/154 Gene Ontology BP GO:0042177 0.394714817393762 0.446645925421492 3315 3125.81818181818 3313 0.0446155118801855 1380 0.993220361181981 1.06632670595933 1 1.17798048199246 3313 2552 3761 2707 2432 3114 3475 4172 1380 3731 3747 3800 M15362 GO_NUCLEOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPHAGY.html A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. 18/20 Gene Ontology BP GO:0044804 0.00102052855398935 0.00403442596577099 3315 2724.81818181818 3315 9.28183873625218e-05 403 0.791061557578251 -1.02480401284713 -1 6.46473477159264 3315 3180 3571 3527 403 3747 4130 2921 584 4004 591 3801 M13914 GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. 556/639 Gene Ontology BP GO:0010256 0.6513215599 0.691390059851284 3310 3348.09090909091 3316 0.1 1325 0.956674662381854 -0.929373871740949 -1 0.513574103966373 3309 1325 4460 1907 3135 4345 3316 3943 2239 4331 4519 3802 M15820 GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION.html Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. 12/29 Gene Ontology BP GO:0007263 0.0735000455084861 0.103010756551502 2790 3228.36363636364 3318 0.00691608958602606 1187 1.31136603868611 1.57282046293274 1 4.41506982373844 2786 4237 1187 3790 3318 4114 4047 1526 4323 3203 2981 3803 M10780 GO_PROTEIN_N_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. 67/81 Gene Ontology BP GO:0006487 0.0048649484996829 0.0123427510190973 3800 2454.45454545455 3319 0.000443249089082273 123 1.12693789136821 -1.07576182220495 -1 7.34301501523599 3796 123 2683 737 727 3319 3957 4178 425 3352 3702 3804 M10822 GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. 44/53 Gene Ontology BP GO:0043496 0.204162961877709 0.247969266932127 2355 3067.54545454545 3319 0.0205460694765369 1700 1.03003796450581 1.29833486654771 1 2.12205338244473 2355 4063 3319 4083 2642 3559 1700 2021 3951 3715 2335 3805 M14571 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 67/72 Gene Ontology BP GO:0051881 0.43119990772354 0.48137552078638 4420 3020.18181818182 3320 0.05 120 1.15299851648566 -0.969558838830208 -1 1.24099842977591 4416 120 1971 1634 4567 3320 4106 4352 1278 2852 4606 3806 M12504 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY.html The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. 14/14 Gene Ontology BP GO:0000244 0.681275400380635 0.691390059851284 3775 3405.36363636364 3321 0.0987278272518212 2483 0.606512402609649 -0.443133296372868 -1 0.321692826066551 3773 3913 3835 3165 2960 3321 3074 2894 2483 4513 3528 3807 M11670 GO_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_PRODUCTION.html The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 20/37 Gene Ontology BP GO:0032612 0.102529223308821 0.136617547553249 4245 3424.45454545455 3322 0.00978586914534804 1757 0.904768653475098 -0.694790858373511 -1 2.66352382677871 4243 3155 2199 3708 1757 4520 3104 2629 4437 3322 4595 3808 M12635 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS.html Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. 58/80 Gene Ontology BP GO:0050690 0.0259254605353115 0.0439349431097345 3325 2825.81818181818 3322 0.00238510102874808 871 0.82292973536057 -0.725815650262681 -1 3.80786369630504 3322 871 3438 1657 1209 3468 3764 3860 3312 3706 2477 3809 M10858 GO_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. 934/1187 Gene Ontology BP GO:0007010 0.0107450504909157 0.0218288194074433 4185 2798.81818181818 3323 0.00107973620838564 262 1.13505755649139 -1.21984699825307 -1 6.43506600241455 4185 1294 4266 262 3323 4281 3841 3830 1946 550 3009 3810 M10684 GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 95/190 Gene Ontology BP GO:0032649 0.262445990852725 0.311441263819875 2940 3085.36363636364 3325 0.0272947562957528 1979 1.11257683506899 1.17508423460318 1 1.9164541566034 2939 3325 1979 3630 3728 3853 3164 2153 3399 2088 3681 3811 M12770 GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. 20/22 Gene Ontology BP GO:0061029 0.159555471107854 0.200222375754289 3130 3133.81818181818 3325 0.0156780115879744 1797 1.19981602723776 1.538642593948 1 2.85460787807599 3127 3506 1797 3800 1961 3429 2767 4343 3449 3325 2968 3812 M13471 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. 25/54 Gene Ontology BP GO:0046641 0.458336438744763 0.507630459538522 2245 3338 3325 0.0542124302645548 1896 0.964063933381431 -0.754012847389049 -1 0.959876824946989 2241 4478 2955 3619 3325 1896 3273 3941 4398 3207 3385 3813 M10603 GO_MICROTUBULE_ANCHORING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ANCHORING.html Any process in which a microtubule is maintained in a specific location in a cell. 22/22 Gene Ontology BP GO:0034453 0.0718808267251748 0.101351965682496 4400 3105 3326 0.00675843426413958 723 0.826191489901149 -0.816047575037142 -1 2.79756831587119 4399 2274 3326 2361 1587 4381 3275 4650 723 3419 3760 3814 M10784 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. 36/48 Gene Ontology BP GO:0045197 0.68618940391 0.691390059851284 4015 3156.18181818182 3329 0.1 1360 1.029478580367 -1.04236212209327 -1 0.553469062458451 4013 2686 2566 1360 3777 4130 3329 4057 2101 2741 3958 3815 M13443 GO_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAPPING.html The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. 38/43 Gene Ontology BP GO:0036260 0.0137417713673233 0.0263889649905717 1950 3134.18181818182 3329 0.00125712402065204 1002 0.586785831712507 -0.651408957271206 -1 3.15626375985645 1947 4416 4130 4103 1002 2138 2528 2819 3517 4547 3329 3816 M10218 GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of leukocyte proliferation. 192/335 Gene Ontology BP GO:0070663 7.73942227142423e-05 0.000615581740665589 3945 2606.36363636364 3330 7.03608595587047e-06 338 1.18789024204686 -1.15040415406132 -1 13.0291210406633 3941 1399 338 519 3119 4112 3557 4360 3330 388 3607 3817 M14394 GO_7_METHYLGUANOSINE_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_7_METHYLGUANOSINE_RNA_CAPPING.html The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. 38/43 Gene Ontology BP GO:0009452 0.0137417713673233 0.0263889649905717 1950 3136.54545454545 3330 0.00125712402065204 1003 0.586785831712507 -0.651408957271206 -1 3.15626375985645 1948 4417 4131 4104 1003 2139 2529 2807 3518 4576 3330 3818 M12590 GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. 11/18 Gene Ontology BP GO:0002830 0.00766161710698187 0.0167525866535652 4365 3108.45454545455 3331 0.000698948174150735 835 1.46188761317899 -1.69338696261257 -1 8.86558353668375 4362 4569 2313 3960 835 3587 2966 1780 3331 3097 3393 3819 M13409 GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. 10/12 Gene Ontology BP GO:0070897 0.0791612915710633 0.109689544276402 3805 3051.63636363636 3332 0.00746927298797128 564 1.36351194486759 1.15806287067149 1 4.4638715576748 3801 3932 3176 3118 3332 3434 3843 1489 564 3020 3859 3820 M15060 GO_COCHLEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_MORPHOGENESIS.html The process in which the cochlea is generated and organized. 24/37 Gene Ontology BP GO:0090103 0.163175933704073 0.20399183759405 3530 2802.09090909091 3332 0.0160642463883125 361 1.24759211688411 -1.20715144105714 -1 2.93415063080755 3529 361 1399 1664 3789 2912 3332 3785 3622 1784 4646 3821 M11057 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 11/14 Gene Ontology BP GO:0033147 0.0050708799315543 0.0127466644377933 3855 3208.63636363636 3334 0.000462055080845916 739 0.418989127074624 -0.353783140996279 -1 2.70336007135772 3855 3247 3398 3992 739 3334 2226 2500 4649 4463 2892 3822 M12255 GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 17/18 Gene Ontology BP GO:0042559 0.385893900658894 0.43772899067914 2005 3108.63636363636 3334 0.0433580948224482 1739 0.993693154258015 -0.800964160174678 -1 1.20830081779711 2004 4198 3707 4003 2659 1739 1889 3461 3334 3967 3234 3823 M10862 GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. 81/87 Gene Ontology BP GO:0006283 0.0725430242863208 0.102130920424887 2245 3229.54545454545 3337 0.00682287892173506 1592 0.58447256966845 -0.606094611985722 -1 1.96931947475323 2242 4010 4163 4106 1592 2140 2468 3337 3967 4391 3109 3824 M14907 GO_PROTEIN_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPHOSPHORYLATION.html The process of removing one or more phosphoric residues from a protein. 183/224 Gene Ontology BP GO:0006470 0.68618940391 0.691390059851284 3340 3035.72727272727 3337 0.1 501 1.02307433627279 1.06176810888713 1 0.549959676433869 3337 1403 2927 501 4016 3721 2922 3752 3071 3408 4335 3825 M13723 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. 27/32 Gene Ontology BP GO:1902307 0.179619008706999 0.221658125238673 3565 3118.09090909091 3341 0.0178377553952929 1030 0.784359654882663 1.02701457942372 1 1.74400718871364 3562 1030 2793 2870 2024 4122 4294 2565 4201 3341 3497 3826 M13683 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. 17/18 Gene Ontology BP GO:1902165 0.330867008184143 0.383156841483528 3855 2984.18181818182 3342 0.0358657859580305 262 1.47052725487049 -1.25394585518247 -1 2.08397618917883 3854 3535 2824 2177 3342 4171 3883 2301 262 3074 3403 3827 M15299 GO_RETINA_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_HOMEOSTASIS.html A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. 68/134 Gene Ontology BP GO:0001895 0.000297468804186124 0.00169830962684421 4205 3090.09090909091 3343 2.70462757707906e-05 416 1.62869108043446 -1.56924330952877 -1 15.4137365353002 4203 3343 416 3895 3067 1644 4287 4644 3254 1259 3979 3828 M16480 GO_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 263/439 Gene Ontology BP GO:0009615 0.517711467425602 0.56773779352612 2620 3202.36363636364 3343 0.06414250801442 1692 1.12519551527554 1.28261483281263 1 0.935126785701092 2616 3634 1826 4316 3343 3716 3096 3697 3167 1692 4123 3829 M13562 GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 9/12 Gene Ontology BP GO:0060394 0.283559790110493 0.333772755725809 3345 3433.54545454545 3344 0.0327961975277288 2281 1.78342661079283 -1.75196595635667 -1 2.89506773222543 3344 4595 4436 4327 2281 3773 3591 2782 2555 2878 3207 3830 M14322 GO_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULOGENESIS.html The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. 68/94 Gene Ontology BP GO:0001570 0.126269482888552 0.163339422819136 3560 3172.09090909091 3344 0.0121962233696946 1329 1.23830181671541 -1.1779089606567 -1 3.32086497628341 3558 3344 1329 3576 3481 3329 3145 2881 3732 2083 4435 3831 M11965 GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. 20/22 Gene Ontology BP GO:1903894 0.00129470867301538 0.00480405060250444 3630 3230 3345 0.000117770112957526 434 0.713911357391936 -0.769825482259081 -1 5.64812830627298 3628 4500 3345 3189 434 2829 3626 2291 4614 4048 3026 3832 M14360 GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 54/68 Gene Ontology BP GO:0030166 0.00531599715394657 0.0131766533742567 3540 2818.63636363636 3345 0.000484444195700187 698 1.47411189928245 -1.4953943381163 -1 9.46535214683068 3539 2141 698 2476 804 3345 4636 4498 3686 1028 4154 3833 M12946 GO_RESPONSE_TO_AMPHETAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMPHETAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. 27/46 Gene Ontology BP GO:0001975 0.68618940391 0.691390059851284 3920 3079.63636363636 3346 0.1 314 1.34251991149055 -1.53435065864258 -1 0.725008881428445 3916 4117 2145 3009 3346 4486 3792 3367 314 2503 2881 3834 M13959 GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 20/23 Gene Ontology BP GO:1900103 0.00740896071727947 0.0163383384917068 4215 3244.90909090909 3347 0.000675820929227996 826 0.725495270293481 -0.713387700392266 -1 4.42135029433113 4211 3162 3111 2235 826 3890 4519 2091 4603 3699 3347 3835 M13495 GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 682/869 Gene Ontology BP GO:0051347 0.411948667205355 0.463554328538456 595 3010.81818181818 3348 0.0517092291234647 591 1.10978257303532 1.19548542622961 1 1.25624766945761 3348 591 4429 595 4172 4482 3337 3825 2189 1508 4643 3836 M13909 GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. 10/31 Gene Ontology BP GO:0045624 0.0557585288569302 0.0818694966144829 3830 3280 3348 0.00520218062295975 1493 1.22540194451934 -1.36722306490521 -1 4.54290427502402 3826 4247 2595 3541 1493 4235 3348 3308 3718 3021 2748 3837 M14621 GO_DNA_GEOMETRIC_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_GEOMETRIC_CHANGE.html The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. 91/101 Gene Ontology BP GO:0032392 0.396644121569782 0.448501846333948 1895 3224.63636363636 3348 0.0448927520805587 1769 0.674767715038178 -0.658825334910276 -1 0.792715540272337 1894 4005 4150 4087 3348 1769 2802 2720 3703 4379 2614 3838 M12485 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. 105/127 Gene Ontology BP GO:2001243 0.0191716285829904 0.0344024634773059 3455 3235.81818181818 3349 0.00175825131707361 1110 1.01224186076565 -0.840839728810138 -1 5.05391060265538 3454 3321 2956 3363 1110 4356 4071 2779 3343 3349 3492 3839 M14798 GO_SOMATIC_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_DIVISION.html The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. 32/39 Gene Ontology BP GO:0048103 0.240065011957603 0.287226150845649 3505 2531.18181818182 3349 0.0246477401076208 489 1.25898179964341 1.2948638721842 1 2.32135392275585 3503 968 1527 650 3349 3950 3614 3842 489 1314 4637 3840 M10610 GO_NEGATIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. 67/78 Gene Ontology BP GO:0051782 0.161750063370254 0.202535803245907 3365 3106.81818181818 3351 0.0159119520352823 1834 1.01854042283327 -0.811162822242317 -1 2.4043310650433 3362 3701 3497 3781 1970 2411 4073 3268 1834 3351 2927 3841 M16069 GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that modulates the frequency, rate or extent of the viral entry into the host cell. 30/69 Gene Ontology BP GO:0046596 0.636396183435236 0.68166469648346 3630 3346.63636363636 3351 0.0878691801489034 2307 1.09285740075215 -1.14057645945132 -1 0.611186970129169 3629 4123 2643 3921 3888 3351 3100 4007 3255 2307 2589 3842 M12588 GO_REGULATION_OF_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESODERM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of mesoderm development. 16/28 Gene Ontology BP GO:2000380 0.0676790856842158 0.0963029925653382 3905 3059.72727272727 3352 0.00635049482066418 1560 1.5587648329068 -1.35220842439276 -1 5.40586128393923 3904 3871 1923 2471 1560 3449 4141 3352 1928 2443 4615 3843 M13428 GO_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRAND_BREAK_REPAIR.html The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. 158/195 Gene Ontology BP GO:0006302 0.499026638393949 0.548821255228186 2860 3454.63636363636 3353 0.0609030690481116 2525 0.734888519428482 -0.778386440829498 -1 0.644028842201382 2860 3985 4166 4456 2585 2525 3254 3353 3805 4404 2608 3844 M15085 GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. 106/158 Gene Ontology BP GO:0043467 0.034295741047052 0.0548213043822605 3140 3091.90909090909 3353 0.00316748578905473 1101 1.00221015052038 1.01448636459972 1 4.31033201902095 3139 2572 2458 3353 3370 4646 3914 1101 3468 2329 3661 3845 M15423 GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 204/230 Gene Ontology BP GO:0006888 0.00306089416433168 0.00888480383445746 3970 2524.09090909091 3353 0.00027865101342187 173 1.03031779906042 -0.962906371136712 -1 7.21543517170734 3967 693 3353 173 593 2267 3579 4623 1039 4020 3458 3846 M10618 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. 20/24 Gene Ontology BP GO:1901032 0.554914891346508 0.603839801084028 2375 3553.27272727273 3355 0.0709474524032882 2372 1.06787217464248 1.32818306054184 1 0.789191738991367 2372 4181 2933 4217 2975 4342 4223 2693 4477 3318 3355 3847 M11143 GO_POSITIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COAGULATION.html Any process that activates or increases the frequency, rate or extent of coagulation. 24/46 Gene Ontology BP GO:0050820 0.0427297094779648 0.0656826356792105 3360 3111.27272727273 3356 0.00396208398460644 1054 1.27138255108445 1.21935303018644 1 5.12963134472913 3356 3479 1054 2844 4211 2424 4383 2475 4356 1777 3865 3848 M11199 GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX.html The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. 14/18 Gene Ontology BP GO:0021819 0.68618940391 0.691390059851284 3355 3587.90909090909 3356 0.1 2474 1.23336456391652 -0.84601138876441 -1 0.66519413270101 3354 3563 3186 4262 4167 3138 2992 4601 2474 3356 4374 3849 M11249 GO_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 47/78 Gene Ontology BP GO:0006801 0.0115558572944961 0.0231166827133665 3670 2796 3356 0.00105609149648014 809 1.36565014444606 1.4386467955751 1 7.62830972498901 3666 3738 809 3508 1373 4063 3103 1263 3356 1704 4173 3850 M15816 GO_PYRUVATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRUVATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. 57/83 Gene Ontology BP GO:0006090 0.000779350386619451 0.00333915041338886 3490 2942.81818181818 3358 7.08751462393596e-05 358 0.929644949128582 -0.777194176559239 -1 7.86023039808381 3486 2134 3268 3709 358 2903 3358 3802 2032 3463 3858 3851 M13991 GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that stops or reduces the activity of an enzyme. 818/1178 Gene Ontology BP GO:0043086 0.310477088245712 0.362886182267596 3990 3181.81818181818 3359 0.0364930089634848 1303 1.08900508800107 -1.0416775240443 -1 1.62842248488974 3988 1303 4463 2487 2329 4226 4053 4204 3359 1424 3164 3852 M11414 GO_DNA_INTEGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRATION.html The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. 7/7 Gene Ontology BP GO:0015074 0.201350779857482 0.245065440407236 3860 3104.09090909091 3360 0.0222324785386774 1529 0.511684391487972 -0.511684391487972 -1 1.05774065126369 3856 1866 4299 1887 4010 3600 2931 3360 2331 4476 1529 3853 M16471 GO_BILE_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 31/68 Gene Ontology BP GO:0008206 0.00379553972835038 0.010384592062893 3360 2723.54545454545 3360 0.000345645802325137 655 1.27453654059002 -1.32734574915998 -1 8.63306580784707 3360 3767 1429 3460 655 4377 3932 1088 4235 2776 880 3854 M16580 GO_BONE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. 31/37 Gene Ontology BP GO:0070977 0.524213419242796 0.574191393535012 3340 3281.09090909091 3361 0.0652965722209337 1833 1.10998545187454 -0.929013259594371 -1 0.903712795772577 3340 3432 1833 3361 4593 2574 4178 3560 3515 3180 2526 3855 M16675 GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 188/214 Gene Ontology BP GO:0035966 0.000827363513429158 0.00346821840359088 3340 3063.27272727273 3362 7.52431661385342e-05 368 0.851884824642602 -0.832523062864006 -1 7.15389875637094 3338 4295 4051 3816 368 2112 3362 2498 3410 4209 2237 3856 M11118 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS.html A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. 15/27 Gene Ontology BP GO:0002087 0.498382274056501 0.548350135063821 2855 3391.36363636364 3364 0.0607933250386467 2583 0.762197939878481 0.780371007066942 1 0.669329961971656 2854 3885 2602 4139 2583 3341 3364 3632 4040 3873 2992 3857 M13943 GO_LIPID_PARTICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. 14/19 Gene Ontology BP GO:0034389 0.151179763926528 0.190840868570303 4515 2933.63636363636 3364 0.0147902474632343 828 0.833172200090556 -1.05251861030925 -1 2.03839655274794 4515 2853 3397 1558 4023 3475 4196 1843 828 3364 2218 3858 M15907 GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. 61/93 Gene Ontology BP GO:0045071 0.445358167326162 0.495286772974564 2510 3147.90909090909 3364 0.0521744311267875 1583 1.34772793471059 1.71835247622666 1 1.39537974699813 2509 4362 2678 4357 2512 3691 3562 3364 1583 1976 4033 3859 M15783 GO_RESPONSE_TO_CYTOKINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CYTOKINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 706/1023 Gene Ontology BP GO:0034097 0.0607451138610868 0.0879150901386117 1985 3008.81818181818 3365 0.00624724355576508 832 1.12799555825424 1.16042430475558 1 4.06161733613868 1982 3954 4571 3514 2836 3398 2807 2264 3365 832 3574 3860 M10874 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. 56/130 Gene Ontology BP GO:0002704 0.523904130150152 0.573987736658502 2355 3089 3369 0.0652413510928855 2016 0.890069460526989 -0.797858590148303 -1 0.72302087655819 2354 3716 2373 3515 3409 2016 3372 3369 4562 2897 2396 3861 M12932 GO_TISSUE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MIGRATION.html The process in which the population of cells that make up a tissue undergo directed movement. 125/181 Gene Ontology BP GO:0090130 0.000343780645689411 0.00187445182457715 3710 2838.27272727273 3371 3.12576707235878e-05 423 1.23711732505998 -1.37043180990883 -1 11.524094659353 3707 2984 423 3715 1330 3537 4402 3579 3371 1206 2967 3862 M10258 GO_EMBRYONIC_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEMOPOIESIS.html The stages of blood cell formation that take place within the embryo. 21/26 Gene Ontology BP GO:0035162 0.0236200800628218 0.040615015717779 3470 3209.45454545455 3372 0.00217068665221339 1182 0.875285464522663 0.912287788597891 1 4.15291898430055 3467 2788 2798 2920 1182 3350 3540 4027 4275 3372 3585 3863 M15506 GO_CEREBRAL_CORTEX_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_CELL_MIGRATION.html The orderly movement of cells from one site to another in the cerebral cortex. 51/66 Gene Ontology BP GO:0021795 0.333861905765996 0.385856792729553 2965 3264.54545454545 3373 0.0362588827626683 1366 1.39264822005458 1.50438251088567 1 1.95852406392811 2962 3730 1755 4270 4587 2864 2135 4631 3373 1366 4237 3864 M12193 GO_SEXUAL_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEXUAL_REPRODUCTION.html A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. 623/1219 Gene Ontology BP GO:0019953 0.479708613650881 0.529808729959067 3655 2978.72727272727 3374 0.0632479253682687 593 1.10571374183085 -1.14793074605417 -1 1.03227106230872 3652 593 4353 1729 2610 3640 3374 3751 1837 2631 4596 3865 M14943 GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. 21/29 Gene Ontology BP GO:1900271 0.00578474305248091 0.0134684294221641 2275 3062.27272727273 3374 0.000527273622858425 481 1.39652755852209 -1.15115274220501 -1 8.92120199491634 2271 4515 2394 4066 3374 3464 2991 481 4277 3748 2104 3866 M11632 GO_CARTILAGE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_MORPHOGENESIS.html The process in which the anatomical structures of cartilage are generated and organized. 13/20 Gene Ontology BP GO:0060536 0.0253159764610031 0.0430695570285366 3645 3114.81818181818 3376 0.00232837048779554 949 1.46798965112611 -1.34631447112409 -1 6.84440782794388 3645 2365 949 2209 3610 4383 3376 3661 3342 2096 4627 3867 M15265 GO_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. 142/251 Gene Ontology BP GO:0034341 0.00193739675861121 0.00639120213122408 3560 3037.45454545455 3377 0.00017628227311286 568 1.09790963356262 1.13388761223985 1 8.22651164697475 3560 2979 568 2518 2804 3909 3377 4400 3734 942 4621 3868 M10207 GO_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION.html The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. 47/80 Gene Ontology BP GO:0051899 0.0163083794338252 0.0302684042702787 4560 3157.63636363636 3379 0.00149368559244308 871 1.2184900493138 -1.34182728748581 -1 6.31746405681202 4556 3379 871 3962 2042 2278 4148 4284 3957 2718 2539 3869 M14160 GO_AMELOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMELOGENESIS.html The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. 15/23 Gene Ontology BP GO:0097186 0.527317173679052 0.576776400829485 4345 3027 3379 0.0658525373208749 260 1.43316372985189 -1.77904501770039 -1 1.16037941917188 4345 3878 1837 2506 3653 3790 4617 2662 260 2370 3379 3870 M15464 GO_POSITIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_KILLING.html Any process that activates or increases the frequency, rate or extent of cell killing. 43/84 Gene Ontology BP GO:0031343 0.0898088412908789 0.122366189905259 2775 3324.45454545455 3379 0.00851811686238806 1693 0.953258434701801 -0.856939457355693 -1 2.96277675667874 2771 4400 2671 4360 1693 2473 3379 4462 4329 3685 2346 3871 M13083 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. 37/42 Gene Ontology BP GO:0032105 0.68618940391 0.691390059851284 3295 3622.72727272727 3381 0.1 2993 1.10549130681986 -0.836791845579301 -1 0.595122377975413 3292 4411 2997 4248 4003 4087 3381 3051 3241 4146 2993 3872 M10884 GO_SNORNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. 10/12 Gene Ontology BP GO:0016074 0.152128140457068 0.191985960820921 3700 3214.36363636364 3382 0.0148903676730824 1582 1.03726506066762 -1.03726506066762 -1 2.53111791469213 3696 3931 3282 3950 1933 2742 2987 4258 1582 3615 3382 3873 M15017 GO_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location. 1841/2309 Gene Ontology BP GO:0008104 0.566002672083603 0.614181537594451 4155 3436.63636363636 3382 0.0800828710067874 2176 0.964459321812843 -0.923541576369437 -1 0.68741508775977 4151 2433 4530 3012 2746 3382 3961 4175 2176 4395 2842 3874 M16938 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. 37/42 Gene Ontology BP GO:0032108 0.654123548497115 0.691390059851284 3295 3605.54545454545 3382 0.0920044359887766 2850 1.10549130681986 -0.836791845579301 -1 0.595122377975413 3293 4412 2998 4249 4004 4088 3382 2850 3242 4149 2994 3875 M14157 GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 594/883 Gene Ontology BP GO:0071345 0.0682732578444726 0.0970890796914214 2600 3195.18181818182 3383 0.00704662552112198 867 1.12931969117831 1.17932359032678 1 3.89995809522732 2597 3621 4476 3489 2716 4033 3290 2505 3383 867 4170 3876 M10697 GO_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_DNA_REPLICATION.html The DNA-dependent DNA replication that takes place as part of the cell cycle. 12/13 Gene Ontology BP GO:0044786 0.68618940391 0.691390059851284 4280 3414.54545454545 3384 0.1 1839 0.599353360452261 -0.652942599388767 -1 0.317769827172862 4278 2879 3619 2852 4014 2868 2768 3384 1839 4452 4607 3877 M16491 GO_PROTEIN_TARGETING_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_LYSOSOME.html The process of directing proteins towards the lysosome using signals contained within the protein. 24/25 Gene Ontology BP GO:0006622 0.0204996332688101 0.0361854300454375 3075 3194.81818181818 3384 0.0018811980692929 1136 0.742083121606071 0.677963439115811 1 3.64654350822393 3075 2767 3413 1688 1136 3014 3631 4315 4593 4127 3384 3878 M16615 GO_RESPONSE_TO_LEAD_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEAD_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. 21/30 Gene Ontology BP GO:0010288 0.0142406762470528 0.0271574087608243 2230 2908.81818181818 3384 0.00130306370443102 756 1.07331154519082 1.36627316831101 1 5.73633391126928 2227 3820 2656 3729 2173 3704 4262 756 3551 3384 1735 3879 M13291 GO_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 34/76 Gene Ontology BP GO:0042446 0.000466163511060435 0.00232328258713774 3615 2994.45454545455 3385 4.23874833569546e-05 285 1.76443725516974 -1.78446059704557 -1 15.8783744827729 3615 3769 1528 3037 285 4434 3815 3385 3956 2619 2496 3880 M11073 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. 15/18 Gene Ontology BP GO:0002204 0.338255254408939 0.390352603860316 3495 3318.18181818182 3386 0.036838450997427 1913 0.904886404504243 0.792058803138712 1 1.25327059811722 3492 3886 3356 3086 4065 3386 3222 2316 1913 3436 4342 3881 M14479 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition. 28/33 Gene Ontology BP GO:1902750 0.322515554222569 0.375064756804329 3975 3001.36363636364 3386 0.0347780008415837 413 1.26623664806697 -1.54335763814376 -1 1.83311495163211 3971 3453 3675 2921 3386 2848 1746 2532 413 3689 4381 3882 M11498 GO_DRUG_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSMEMBRANE_TRANSPORT.html The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 28/45 Gene Ontology BP GO:0006855 0.0486856420732048 0.0729207602279388 3005 3228.27272727273 3387 0.00452705964565431 1261 1.07594288977895 -1.04359033865616 -1 4.17244392966286 3001 3785 1986 3906 2578 4618 4032 1261 4081 3387 2876 3883 M11899 GO_ADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. 44/64 Gene Ontology BP GO:0046031 0.000590716689709923 0.00274298329475171 4250 2894.27272727273 3387 5.37159419338139e-05 316 0.917390683532422 -0.829572497504064 -1 8.02437714827613 4246 3387 3360 4131 316 1515 1530 3528 2717 3486 3621 3884 M13836 GO_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOTYPE_SWITCHING.html The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 15/18 Gene Ontology BP GO:0045190 0.368642410202608 0.421655146183072 3495 3325 3387 0.0409456518033803 1914 0.904886404504243 0.792058803138712 1 1.14962866774247 3493 3887 3357 3087 4066 3387 3223 2375 1914 3443 4343 3885 M11095 GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. 14/24 Gene Ontology BP GO:0048172 0.605078200897137 0.650966212433383 3680 3382.27272727273 3388 0.0809922125067809 2529 1.08893256268751 -1.08204519490837 -1 0.683459746988147 3680 3212 2598 3014 3556 3619 4533 4290 3388 2786 2529 3886 M14018 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE.html The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. 15/18 Gene Ontology BP GO:0002208 0.319710560273406 0.372182446072594 3495 3316.81818181818 3388 0.0344153813175525 1915 0.904886404504243 0.792058803138712 1 1.3173151060278 3494 3888 3358 3088 4067 3388 3224 2275 1915 3444 4344 3887 M15771 GO_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_CHECKPOINT.html A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. 230/269 Gene Ontology BP GO:0000075 0.420371941416023 0.471891590689687 2525 3105.54545454545 3389 0.0483699941398899 1316 0.984489420315419 -0.977274310175916 -1 1.08715739022622 2525 3967 3942 3389 4250 2004 3962 2573 1316 4116 2117 3888 M10834 GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that activates or increases the frequency, rate or extent of membrane invagination. 20/22 Gene Ontology BP GO:1905155 0.0116888914740537 0.0232960178049697 3390 2862.09090909091 3390 0.00106831472951033 692 1.46988023478356 1.58178121380143 1 8.19447036048109 3390 1736 1298 2085 4020 4277 3817 692 3945 2350 3873 3889 M12072 GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. 43/57 Gene Ontology BP GO:0031057 0.68618940391 0.691390059851284 2900 3434.36363636364 3391 0.1 2712 0.745145434817822 0.652820499486918 1 0.397660702777584 2900 3391 4043 3443 3651 2877 2712 4269 3084 4302 3106 3890 M14759 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 20/22 Gene Ontology BP GO:0060100 0.0127280288458065 0.0248629379595037 3395 2866.18181818182 3391 0.00116384258734249 720 1.46988023478356 1.58178121380143 1 8.05239727896563 3391 1737 1299 2086 4021 4278 3818 720 3946 2358 3874 3891 M13820 GO_RESPONSE_TO_CAFFEINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAFFEINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. 28/34 Gene Ontology BP GO:0031000 0.216290625692386 0.260995923585755 3100 3345.63636363636 3392 0.0219124495199135 2115 0.921495963383183 0.92392314714093 1 1.8272596728695 3100 2229 2396 3300 2115 4529 3650 4625 4052 3392 3414 3892 M14107 GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 23/45 Gene Ontology BP GO:0050996 0.68618940391 0.691390059851284 3325 3297.09090909091 3392 0.1 2106 0.914824778364745 0.812170700357817 1 0.490641280679289 3324 2259 2209 2106 4150 4029 3392 4613 3865 2607 3714 3893 M10466 GO_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DEGRANULATION.html The regulated exocytosis of secretory granules by a leukocyte. 35/68 Gene Ontology BP GO:0043299 0.68618940391 0.691390059851284 3825 3245 3393 0.1 2203 1.14041336275034 -1.26878506306531 -1 0.614258902634549 3823 2203 2290 3536 4560 3684 3393 3110 2222 2670 4204 3894 M16645 GO_ORGANELLE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_DISASSEMBLY.html The disaggregation of an organelle into its constituent components. 197/263 Gene Ontology BP GO:1903008 0.0780677256130593 0.108400217032995 3600 3169.72727272727 3393 0.00736217572562385 744 1.07766882831558 -1.10986047954763 -1 3.54476193231348 3597 4292 3179 3942 3841 744 3345 3325 3393 3856 1353 3895 M14850 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 809/1011 Gene Ontology BP GO:0080135 0.6513215599 0.691390059851284 3330 3567.45454545455 3394 0.1 1893 0.967140748883521 -0.919599703367188 -1 0.519309291001825 3327 1893 4520 2957 2939 4578 3394 4135 3001 3943 4555 3896 M16503 GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. 175/203 Gene Ontology BP GO:2001020 0.505027156967536 0.554743003156267 2815 3208.45454545455 3395 0.0619312464074576 2148 0.992431172672451 1.01170687210337 1 0.857651576096351 2814 3976 3602 3395 3376 3396 2148 2619 2793 3497 3677 3897 M12760 GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. 15/16 Gene Ontology BP GO:0070243 0.572218358619939 0.620058691816157 3520 3104 3396 0.0742904582796514 1762 1.45342703509501 -1.58382329650182 -1 1.02077823473227 3519 3556 1890 2435 3057 4152 3396 2831 3455 1762 4091 3898 M10782 GO_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDLIMB_MORPHOGENESIS.html The process in which the anatomical structures of the hindlimb are generated and organized. 35/54 Gene Ontology BP GO:0035137 0.0107162506091765 0.0217931442677004 4375 3128.18181818182 3398 0.000978982588944939 656 1.25148754749584 -1.66051709857739 -1 7.09928437276496 4371 3762 1884 3621 3064 3037 4625 656 3415 3398 2577 3899 M14854 GO_PHARYNGEAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHARYNGEAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. 22/36 Gene Ontology BP GO:0060037 0.326718950713949 0.3794865895337 3400 3324.18181818182 3398 0.0353239641643681 1757 1.22068648035872 -1.17582873681635 -1 1.74554531455628 3398 4488 1941 4144 3749 4327 1757 3344 4026 2987 2405 3900 M12435 GO_MITOTIC_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis. 49/58 Gene Ontology BP GO:0090307 0.390125767240765 0.441775418586342 3405 3224.45454545455 3401 0.0439592816709048 492 1.20882043134244 -1.43740540284266 -1 1.45568146497732 3401 4050 3525 3073 4416 3895 4224 3222 492 3127 2044 3901 M12341 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 18/19 Gene Ontology BP GO:0033160 0.00683861216356331 0.0153202033688301 4545 3096.63636363636 3402 0.000623632971687931 531 1.42660248910812 -1.77304843469436 -1 8.84067112412636 4545 3850 3027 2712 3988 3720 3402 531 1457 3595 3236 3902 M13120 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS.html Any microtubule cytoskeleton organization that is involved in mitosis. 49/58 Gene Ontology BP GO:1902850 0.390125767240765 0.441775418586342 3405 3211.27272727273 3402 0.0439592816709048 493 1.20882043134244 -1.43740540284266 -1 1.45568146497732 3402 4051 3526 3074 4417 3896 4225 3067 493 3128 2045 3903 M10312 GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE.html Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. 74/108 Gene Ontology BP GO:0035019 0.0213291814596294 0.037380294286876 2550 3150.36363636364 3404 0.00195807460642439 1155 1.10172948046454 1.24007250259267 1 5.36584262326666 2550 3693 2738 3680 1155 4269 2843 3850 3572 2900 3404 3904 M10962 GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. 18/28 Gene Ontology BP GO:0032780 0.49548204771393 0.545417073104547 3885 3352.27272727273 3406 0.0603009581504326 2118 1.36115883022296 -1.01810332221109 -1 1.2145307878955 3885 4514 2519 4309 3406 2118 2677 2605 4218 3590 3034 3905 M12719 GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-beta production. 48/71 Gene Ontology BP GO:0032728 0.072312156868728 0.101867534335511 2330 3161.72727272727 3406 0.00680040629905418 1312 0.912191311548609 0.985349754173365 1 3.08300985333268 2329 4389 3406 4604 3569 2647 1312 1448 4147 4033 2895 3906 M16760 GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 232/280 Gene Ontology BP GO:0009895 0.68618940391 0.691390059851284 3420 3200.81818181818 3407 0.1 1964 0.974220600444768 1.01464454332982 1 0.523188895176749 3417 1964 3609 2467 3147 3407 3248 4144 2221 3496 4089 3907 M12076 GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 23/34 Gene Ontology BP GO:0072529 0.0177093389982588 0.0322454399021311 1165 2532.18181818182 3408 0.00162304739742622 347 0.908782088176399 -0.908782088176399 -1 4.62364278534051 1161 4491 3408 4324 4299 365 347 867 3908 3826 858 3908 M12567 GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. 20/24 Gene Ontology BP GO:2000269 0.0481519131644695 0.0722744683723473 2095 3066.72727272727 3408 0.00447629951623426 647 0.854962280429747 0.734800464579436 1 3.32460545245685 2091 4520 3488 4447 2918 1568 647 3408 4407 3693 2547 3909 M11037 GO_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMISSION_OF_NERVE_IMPULSE.html The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. 42/102 Gene Ontology BP GO:0019226 0.0651268518854425 0.0929555956512159 3880 3112.45454545455 3409 0.00610351824375644 1158 1.17031740995039 -1.34118206016187 -1 4.11752852596659 3878 3389 1158 3728 2040 2395 3880 3855 4202 3409 2303 3910 M11089 GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 311/351 Gene Ontology BP GO:0045732 0.00577426225782821 0.0134540021460564 3740 2582.63636363636 3409 0.000526315789473684 216 0.902130059847926 -0.798681792873771 -1 5.76058647965937 3739 644 4099 216 3642 1400 3409 3517 1173 4101 2469 3911 M14417 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. 50/115 Gene Ontology BP GO:0002707 0.409029245032306 0.460826410928649 2415 3177.54545454545 3410 0.046691924862393 1801 0.901275799589931 -0.822629969062039 -1 1.02611812820036 2412 4046 2400 3582 3644 1801 3505 3410 4570 3182 2401 3912 M14821 GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 50/58 Gene Ontology BP GO:0010799 0.68618940391 0.691390059851284 3765 3177.81818181818 3410 0.1 924 1.07294471695976 1.00966383596582 1 0.577287556890753 3762 2647 2682 3358 4136 4126 3410 4052 924 2268 3591 3913 M11314 GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS.html Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 10/12 Gene Ontology BP GO:0050930 0.0300393505827021 0.0492332153086696 3980 3233.54545454545 3414 0.00276886650016815 1139 2.07634653641772 -2.80046009529594 -1 9.27289110161814 3977 4596 2352 4369 1269 3778 3414 1139 3287 3015 4373 3914 M13420 GO_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a protein. 875/1131 Gene Ontology BP GO:0006468 0.41764334677006 0.469168153674817 3115 3039.72727272727 3415 0.0526315789473684 382 1.0491306678696 1.0893823405009 1 1.16825638741534 3115 582 4427 382 4591 4308 3415 3569 2147 2284 4617 3915 M11562 GO_DNA_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEALKYLATION.html The removal of an alkyl group from one or more nucleotides within an DNA molecule. 17/20 Gene Ontology BP GO:0035510 0.231099154602741 0.277497900997821 2985 3218.45454545455 3416 0.0236071820487738 2088 0.809891227313773 0.853978779669631 1 1.53093750197168 2983 3543 3614 3997 4222 2282 2725 2088 3416 3966 2567 3916 M15613 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. 19/21 Gene Ontology BP GO:0060742 0.0124311157582866 0.024405899419117 4010 3046.63636363636 3416 0.0011365380549875 970 1.21631564396881 0.973701324859164 1 6.69497100332332 4006 3526 2143 3843 970 3516 3424 3215 3204 2250 3416 3917 M11103 GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 374/577 Gene Ontology BP GO:0019221 0.00661338025113535 0.0149117299635235 4580 3205.90909090909 3418 0.000603031335029663 726 1.08611897201995 -0.9817722985111 -1 6.7717283485298 4579 2475 726 2971 3418 3163 4551 4474 3535 1853 3520 3918 M13382 GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. 17/19 Gene Ontology BP GO:0007095 0.0191068698246358 0.0343127230003976 2445 2865.63636363636 3420 0.0017522598178953 474 0.910736847697943 0.910736847697943 1 4.54958032107874 2444 4195 3872 4250 3420 1255 474 843 3502 4543 2724 3919 M13937 GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. 26/66 Gene Ontology BP GO:0002228 0.68618940391 0.691390059851284 4400 3466.27272727273 3420 0.1 1675 0.933643978596226 0.754798636636119 1 0.500953791775768 4400 1675 2475 2517 3166 4396 4616 4368 3836 3260 3420 3920 M11237 GO_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_TRANSPORT.html The directed movement of substances into, out of or within a vacuole. 290/316 Gene Ontology BP GO:0007034 0.0614121418051326 0.0886696618406947 3090 3412.27272727273 3421 0.00574514334337057 1527 0.772507709783221 0.776481516036631 1 2.76843508556236 3090 2487 4193 2225 1527 3749 3318 4578 3421 4412 4535 3921 M14986 GO_HISTONE_H3_K4_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_TRIMETHYLATION.html The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. 16/18 Gene Ontology BP GO:0080182 0.0645721525655607 0.0922825831319811 3340 3231.81818181818 3421 0.00604992175802073 1546 1.61109716548804 -2.10411761541957 -1 5.68972310052783 4034 3554 2342 3340 1546 4255 3566 3421 3700 2452 3340 3922 M16031 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. 53/70 Gene Ontology BP GO:0042273 0.0493392165994444 0.0737710073384366 4095 2813.09090909091 3423 0.0045892529311942 436 0.628195346759087 0.543575640447147 1 2.4208547815832 436 3736 4095 4093 3423 1237 656 1805 4314 4341 2808 3923 M16296 GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. 22/35 Gene Ontology BP GO:0032925 0.0194985149034443 0.034854625372926 2820 3105 3424 0.00178850042493862 854 0.899057487698363 1.01870826002294 1 4.47018127351104 2816 4492 3367 4513 4261 3845 3916 854 1492 3424 1175 3924 M10274 GO_NUCLEAR_ENVELOPE_REASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_REASSEMBLY.html The reformation of the nuclear envelope following its breakdown in the context of a normal process. 23/24 Gene Ontology BP GO:0031468 0.68618940391 0.691390059851284 2625 3307.36363636364 3425 0.1 718 0.820234241898362 0.892744427657002 1 0.438807730638211 2624 3814 3901 3425 4494 3206 2880 3851 718 4111 3357 3925 M11195 GO_VESICLE_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_TARGETING.html The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. 110/125 Gene Ontology BP GO:0006903 0.000466354166427391 0.00232328258713774 4400 2983.63636363636 3426 4.24048230129863e-05 286 0.988038107706616 -0.880669002608976 -1 8.88677706835974 4398 2051 3106 1387 286 3426 3738 4041 2626 3776 3985 3926 M14488 GO_NEGATIVE_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JNK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. 53/66 Gene Ontology BP GO:0046329 0.267533228493644 0.316590059049065 2085 3102.18181818182 3427 0.0279066024405559 1683 0.969711065234893 1.06554373958819 1 1.64538415955832 2082 4044 3482 4079 2818 3139 1683 3427 3905 3775 1690 3927 M12930 GO_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 33/81 Gene Ontology BP GO:0002377 0.308778285268365 0.361172790687205 3835 3365.18181818182 3428 0.0330149468192572 2282 1.14376403072777 1.41618494405409 1 1.71887896444086 3833 3428 2493 3467 2282 3956 3153 3251 4217 2542 4395 3928 M14457 GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 594/724 Gene Ontology BP GO:0051493 0.6513215599 0.691390059851284 3810 3235.63636363636 3428 0.1 1824 1.06688167931616 -1.0802451792972 -1 0.573965144556067 3807 2449 4494 1824 3428 4608 3834 3786 2088 1851 3423 3929 M11104 GO_ATP_GENERATION_FROM_ADP http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_GENERATION_FROM_ADP.html The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. 34/54 Gene Ontology BP GO:0006757 0.00138280299491592 0.00502670494948733 4230 2883.45454545455 3430 0.000125788446993914 449 0.934035113475329 -0.729723713956792 -1 7.33009773203589 4227 3430 3462 3750 449 2097 1799 3227 1618 3630 4029 3930 M11732 GO_ANATOMICAL_STRUCTURE_ARRANGEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_ARRANGEMENT.html The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 32/39 Gene Ontology BP GO:0048532 0.0751865883771431 0.10496345506116 3200 3333.81818181818 3431 0.00708056646533057 1533 1.35132219535814 1.16981116258313 1 4.51223854701466 3197 4115 1533 4269 1614 4164 3041 3431 4155 2855 4298 3931 M14300 GO_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 65/100 Gene Ontology BP GO:0046631 0.547404255445937 0.596364317628178 4340 3241 3434 0.0695330504474637 1909 1.12267013438601 -0.990330427669376 -1 0.851002146331944 4339 4030 2141 2636 2703 4014 3434 2687 3683 1909 4075 3932 M15301 GO_MITOCHONDRION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_MORPHOGENESIS.html The process in which the anatomical structures of a mitochondrion are generated and organized. 28/37 Gene Ontology BP GO:0070584 0.4635003545962 0.512759664749434 3435 3395.18181818182 3434 0.0550356955395668 2032 0.613954141370855 -0.643499169197298 -1 0.598250390654509 3434 4118 3833 4535 2965 2032 2473 2676 4468 4607 2206 3933 M13885 GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE.html A process of chromosome organization that is involved in a meiotic cell cycle. 31/56 Gene Ontology BP GO:0070192 0.307995051034773 0.360381253432867 2765 3213 3435 0.0329153884479186 1803 0.853778566981015 -0.999155613377333 -1 1.2831590623352 2761 3457 3848 3435 4345 1842 2702 3037 3897 4216 1803 3934 M14361 GO_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. 11/18 Gene Ontology BP GO:0030851 0.0108849548947982 0.0220399021433838 2585 3025.63636363636 3435 0.000994471498591067 248 0.379451689485774 -0.400255197760591 -1 2.13873338528016 2585 4593 3435 4567 2805 686 248 3763 4584 4573 1443 3935 M16460 GO_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERAD_PATHWAY.html Any process that modulates the frequency, rate or extent of ERAD pathway. 36/37 Gene Ontology BP GO:1904292 0.000807892986054377 0.0034111851761443 4510 3073.81818181818 3437 7.3471801493854e-05 245 0.828424867899502 0.833777458161258 1 6.97699082572733 4507 245 3437 1924 367 4263 4308 3138 3205 3955 4463 3936 M14352 GO_CYCLOOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLOOXYGENASE_PATHWAY.html The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. 12/22 Gene Ontology BP GO:0019371 0.00827562883137393 0.0178234682382376 4205 3030.18181818182 3438 0.000755174889052863 859 1.44700383149521 -1.55213457726192 -1 8.64208097048443 4205 3237 862 4306 859 3979 3144 3508 4420 1374 3438 3937 M11973 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. 118/218 Gene Ontology BP GO:0070665 0.0351915817745031 0.0560967557371575 4395 2996.81818181818 3441 0.00325158644069702 1014 1.06469239063897 -1.02315320221167 -1 4.54336308171382 4395 2558 1014 2031 2358 3441 4165 3502 4139 1695 3667 3938 M16176 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition. 36/44 Gene Ontology BP GO:1902808 0.0643851980167173 0.0921709437403109 2645 3118.54545454545 3441 0.00603186423494155 813 0.793553452246541 -0.844339552233686 -1 2.79851530595259 2642 4084 3741 4053 1737 2712 3441 2512 4317 4252 813 3939 M13281 GO_4_HYDROXYPROLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_HYDROXYPROLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. 15/15 Gene Ontology BP GO:0019471 0.00445930388586017 0.0116046649781361 3575 2954.36363636364 3442 0.00040621531211712 192 1.32022175198265 1.17310316219581 1 8.72513802761164 3574 3884 2914 2392 705 4038 4479 2971 192 3442 3907 3940 M13568 GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. 32/43 Gene Ontology BP GO:0048713 0.327479539277326 0.380211993259832 3445 3341.81818181818 3442 0.0354230850818848 2318 1.26382961809456 1.23468827406736 1 1.80403185524764 3191 4102 2589 3442 2318 3444 3260 3480 4187 3244 3503 3941 M15838 GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 23/27 Gene Ontology BP GO:0033598 1.53482992709945e-05 0.000181791405797353 3445 2398.54545454545 3442 1.39530966813137e-06 37 1.35518789251218 -1.56448903560476 -1 17.3199162762814 3442 1025 1110 222 37 3957 3879 4261 3538 657 4256 3942 M16641 GO_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOLYSIS.html The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. 1051/1543 Gene Ontology BP GO:0006508 0.387710102070108 0.439360717226549 4485 3014.72727272727 3442 0.0478711835235842 576 1.06483606708395 -0.970390650216866 -1 1.28968891515282 4485 576 4641 714 2461 2834 4343 4363 1841 3462 3442 3943 M16397 GO_RECIPROCAL_MEIOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_MEIOTIC_RECOMBINATION.html The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. 30/42 Gene Ontology BP GO:0007131 0.381784550531095 0.433819064876804 2880 3260.27272727273 3443 0.0427779063608993 1729 0.749954014296026 -0.749954014296026 -1 0.919297262393622 2880 3793 3907 4411 2851 1729 2659 3523 3443 4202 2465 3944 M14752 GO_MULTICELLULAR_ORGANISMAL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_SIGNALING.html The transfer of information occurring at the level of a multicellular organism. 94/189 Gene Ontology BP GO:0035637 0.000412028030103866 0.00211841593820253 4005 3217 3444 3.74641106550543e-05 435 1.22117901776213 -1.4092467337822 -1 11.1536329105327 4003 3673 435 4141 3444 3189 4441 2467 4129 2955 2510 3945 M14706 GO_RRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an rRNA molecule. 13/14 Gene Ontology BP GO:0031125 0.14726493155165 0.18640471341399 2845 3296.63636363636 3445 0.0143780315811823 1917 0.593198550542442 -0.593198550542442 -1 1.46893431929175 2843 3226 3786 3963 1917 2736 2081 3445 4106 4584 3576 3946 M13231 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. 31/36 Gene Ontology BP GO:2000142 0.01278399257435 0.0249513076545515 3195 3226.09090909091 3446 0.00116898992424125 982 1.04732495405871 1.1150240939342 1 5.7289436405679 3194 3446 3421 3803 982 3840 3757 3535 2319 3819 3371 3947 M15231 GO_ISOPRENOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 25/33 Gene Ontology BP GO:0008299 2.7322578698146e-05 0.000283144674125775 3905 2723.63636363636 3447 2.48390163934744e-06 67 1.3339347256116 -1.32278987470902 -1 16.1704945227326 3905 3465 2035 2497 67 3488 3447 4250 1198 1883 3725 3948 M15960 GO_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REPOLARIZATION.html The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. 13/28 Gene Ontology BP GO:0086009 0.191707289037728 0.235049806559301 3450 3449 3447 0.0191622980562264 1453 2.05848451112135 -2.09208982432629 -1 4.41501971820768 3447 4567 1453 4518 4274 3405 1480 4622 2895 2707 4571 3949 M12302 GO_LIPOPROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_TRANSPORT.html The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/19 Gene Ontology BP GO:0042953 0.68618940391 0.691390059851284 3450 3430.90909090909 3449 0.1 2362 1.26399167792467 1.28677251972969 1 0.681977122901298 3449 3552 2362 3812 4302 3992 3927 2975 2899 3359 3111 3950 M14212 GO_LIPOPROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_LOCALIZATION.html Any process in which a lipoprotein is transported to, or maintained in, a specific location. 14/19 Gene Ontology BP GO:0044872 0.68618940391 0.691390059851284 3450 3436.72727272727 3450 0.1 2363 1.26399167792467 1.28677251972969 1 0.681977122901298 3450 3553 2363 3813 4303 3993 3928 3023 2900 3366 3112 3951 M14413 GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE.html The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein. 34/36 Gene Ontology BP GO:0072661 0.0956977344942849 0.128982993967053 2795 3190.54545454545 3450 0.00910300628602375 1583 0.907488584686772 1.09483991387139 1 2.74904883404056 2795 3098 2891 4142 3925 3450 2005 1583 3623 4106 3478 3952 M16269 GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 799/1010 Gene Ontology BP GO:0051129 0.6513215599 0.691390059851284 3300 3196.18181818182 3450 0.1 1368 1.12617021784693 -1.04175577172084 -1 0.606453970009435 3296 3273 4611 1368 3808 3887 3499 3450 1617 1835 4514 3953 M13201 GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER.html The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. 14/16 Gene Ontology BP GO:0006390 0.00403265607029454 0.0108524862319725 3455 2886.90909090909 3451 0.000367278823361383 124 1.22488717524803 -1.37627737713113 -1 8.21619661634292 3451 4221 3556 3767 4401 552 124 2331 3982 3362 2009 3954 M14303 GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-RNA complex into its constituent components. 17/17 Gene Ontology BP GO:0032988 0.00180758002587843 0.00609587405331511 3540 2841.27272727273 3451 0.000164460626685396 24 1.01849377530049 -1.15366249810991 -1 7.7022331818451 3914 3536 3451 1655 494 4245 3365 3745 24 3537 3288 3955 M10563 GO_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that modulates the frequency, rate or extent of cellular senescence. 40/46 Gene Ontology BP GO:2000772 0.512354301743366 0.562260510851859 4480 3535.54545454545 3452 0.0632022169169295 2609 0.95077880309038 -1.05000829023597 -1 0.802205835228711 4479 2684 2892 4356 2609 4458 3361 3452 3866 3834 2900 3956 M11058 GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a type 2 immune response. 17/45 Gene Ontology BP GO:0002828 0.0204404339083051 0.0361162605198555 3455 3334.54545454545 3452 0.00187571416289734 1135 1.25423586072265 -1.54728992466744 -1 6.17414776999362 3452 4532 2617 4351 1135 4384 4374 1793 3527 3069 3446 3957 M13533 GO_REGULATION_OF_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_DUPLICATION.html Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 36/42 Gene Ontology BP GO:0010824 0.0686041742776223 0.0974702970729089 3455 3219.72727272727 3453 0.00644016631137824 1423 0.810948028455727 -0.742804012899555 -1 2.79277846466206 3453 3759 3928 3601 4604 2987 3440 1423 2490 4133 1599 3958 M11256 GO_SULFATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATE_TRANSPORT.html The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/14 Gene Ontology BP GO:0008272 0.0230051651507326 0.0397338654218109 3045 3493.81818181818 3454 0.00232468509455511 953 1.1494727381735 1.1494727381735 1 5.49461677462739 3045 4603 4289 4328 3620 2873 3378 953 4486 3403 3454 3959 M12735 GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is divided into specific regions along the rostrocaudal axis. 13/21 Gene Ontology BP GO:0021903 0.68618940391 0.691390059851284 3915 3118.36363636364 3454 0.1 578 1.17208393173443 -1.0201430427095 -1 0.631613683393717 3911 1811 2765 1938 3646 4652 3454 4494 578 3284 3769 3960 M13066 GO_MIDDLE_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDDLE_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). 19/30 Gene Ontology BP GO:0042474 0.13291857161556 0.17070662813337 3215 3308.36363636364 3454 0.012881979316846 1343 1.20967454705988 1.2846221237916 1 3.16460658539435 3214 3529 1343 3606 2142 4260 3407 3454 4267 2730 4440 3961 M10434 GO_MRNA_SPLICE_SITE_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_SPLICE_SITE_SELECTION.html Selection of a splice site by components of the assembling spliceosome. 30/42 Gene Ontology BP GO:0006376 0.68618940391 0.691390059851284 2525 3159 3455 0.1 778 0.746772887753711 -0.941427060311993 -1 0.398552511475824 2521 3455 3723 1654 3713 3232 2776 4313 778 4034 4550 3962 M14408 GO_CELLULAR_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 45/62 Gene Ontology BP GO:0071359 0.68618940391 0.691390059851284 2965 3375.27272727273 3455 0.1 1672 1.10105821109478 1.14723986875409 1 0.59269313824714 2963 4397 3365 4597 3764 3634 2744 3455 1672 2600 3937 3963 M16306 GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of a defense response. 369/564 Gene Ontology BP GO:0031349 0.0149679823338009 0.0282310586944368 3460 2764.81818181818 3456 0.00137007269167926 629 1.14782194270326 1.22976437186119 1 6.0692149977344 3456 629 860 783 4525 4564 3583 4091 2464 1158 4300 3964 M15407 GO_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 794/1446 Gene Ontology BP GO:0009607 4.81738882537071e-07 9.30095859105806e-06 2625 3214.81818181818 3457 4.8173898696966e-08 95 1.23122157856582 1.26520336781466 1 21.169228250159 2625 2443 4554 3457 3911 3921 3178 3688 3248 95 4243 3965 M15517 GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA.html Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. 29/32 Gene Ontology BP GO:0060330 0.598687297004082 0.645134782992124 4160 3205.72727272727 3457 0.0796500532180234 865 0.906173691621174 -1.00458766498159 -1 0.579070633134372 4160 2223 3457 2181 2743 3927 4554 4136 865 3428 3589 3966 M11476 GO_MALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GAMETE_GENERATION.html Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. 416/832 Gene Ontology BP GO:0048232 0.620083752705769 0.666185569462005 3920 3373.27272727273 3459 0.0842228436018365 2163 1.03734464077847 0.906738186458003 1 0.614979170136227 3919 2943 3134 3200 2774 3762 3459 4379 2163 3519 3854 3967 M14428 GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 27/35 Gene Ontology BP GO:0051569 0.318796944856717 0.371211757862438 3770 3022.18181818182 3461 0.034297565832318 76 1.35352248632875 -1.79014616317307 -1 1.98096531187495 3767 3461 3578 2922 3843 3855 4055 2501 76 3343 1843 3968 M10273 GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON.html A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. 38/38 Gene Ontology BP GO:0044380 0.00975062245903063 0.0202091965709886 3465 3003.72727272727 3462 0.000890373479188187 902 0.836945602300805 0.840393767025177 1 4.83796286973054 3462 3073 3678 2868 902 3615 3469 3146 1119 3786 3923 3969 M10398 GO_CELL_PART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PART_MORPHOGENESIS.html The process in which the anatomical structures of a cell part are generated and organized. 711/988 Gene Ontology BP GO:0032990 0.0185894220848719 0.0335258065739958 3305 2762 3462 0.00187467829054406 631 1.18050049550113 -1.14864821768775 -1 5.94100853406196 3301 1310 4237 704 3462 3902 3624 3559 1676 631 3976 3970 M15633 GO_FOREBRAIN_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. 6/14 Gene Ontology BP GO:0021877 0.00046918140827812 0.00232364264403131 3830 3195.36363636364 3462 4.69280496760597e-05 303 0.754819361483446 0.923479781420522 1 6.78643160160747 3827 3947 4567 3979 303 3462 1944 2273 4290 3307 3250 3971 M15814 GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 33/56 Gene Ontology BP GO:0007215 0.516019742235398 0.566149460179512 3695 3068.36363636364 3462 0.0638445545329081 1199 1.07681020484858 -0.913760961909681 -1 0.898935616897002 3695 2211 1943 3462 2615 3331 3480 4208 1199 3586 4022 3972 M16609 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_SNRNP_ASSEMBLY.html The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. 39/45 Gene Ontology BP GO:0000387 0.364257265404341 0.417152118121191 1805 3212.90909090909 3463 0.0403419925768827 1804 0.533117248624828 -0.52974751095267 -1 0.68142649580296 1804 4079 4110 3663 3463 2250 1837 2600 3860 4645 3031 3973 M10132 GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION.html Any process that set the alignment of spindle relative to other cellular structures. 28/33 Gene Ontology BP GO:0051294 0.118979752859071 0.155204034217342 3460 3501.36363636364 3464 0.0114498252726516 1717 0.855894304178823 -0.784029773455404 -1 2.35696348395031 3460 4471 3464 4386 3024 2760 2672 1717 4516 3985 4060 3974 M10235 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that activates or increases the rate of gene expression. 77/111 Gene Ontology BP GO:0045815 0.0896844379292063 0.122232480868365 3565 3300.81818181818 3466 0.00850579816968308 1301 1.06755311126217 -1.332078189565 -1 3.32102201965168 3563 3338 3273 4190 1692 4241 3140 3704 1301 3466 4401 3975 M12025 GO_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENTATION.html The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. 87/105 Gene Ontology BP GO:0043473 0.0907254797742354 0.123297314890249 3470 3385.90909090909 3468 0.0086089316263301 1698 0.977922463680115 0.940207720783052 1 3.02870242781005 3468 3328 3182 3591 1698 3055 2964 4088 3938 3547 4386 3976 M10043 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY.html A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. 26/46 Gene Ontology BP GO:0045005 0.224763449314382 0.270378575403262 3215 3387.72727272727 3469 0.0228785045548409 2070 0.772511914273307 0.552443216383835 1 1.48959935781361 3211 3469 3803 4004 4316 3046 2613 2070 2481 4153 4099 3977 M11010 GO_NEGATIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RNA_SPLICING.html Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. 34/50 Gene Ontology BP GO:0033119 0.0643988261551151 0.0921709437403109 4105 3326.45454545455 3469 0.00603318043560015 1543 0.681327985370301 -0.826998683761021 -1 2.40123731986027 3201 4103 3915 3187 1543 3823 2766 3469 2035 4104 4445 3978 M16920 GO_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. 119/127 Gene Ontology BP GO:0007030 0.68618940391 0.691390059851284 3285 3286.45454545455 3470 0.1 1015 0.92867453572231 -0.850780765926423 -1 0.498230645512897 3282 1448 4050 2416 4545 4183 3470 4194 1015 4226 3322 3979 M10436 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 1468/2161 Gene Ontology BP GO:0010629 0.599629405388797 0.64570137081094 2485 3451.90909090909 3473 0.0874719620043699 2420 1.04907101189195 1.03850247315946 1 0.670700066137783 2481 4274 4239 4179 3091 3027 2420 3473 2509 4018 4260 3980 M11267 GO_CELLULAR_COMPONENT_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MAINTENANCE.html The organization process that preserves a cellular component in a stable functional or structural state. 23/26 Gene Ontology BP GO:0043954 0.331280673778137 0.383540426745378 3605 2967.09090909091 3475 0.0359199865258992 344 0.911544236972841 -0.885037867499449 -1 1.28639888872477 3602 344 2851 378 4632 4070 2563 2303 4203 3475 4217 3981 M12430 GO_DNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_MODIFICATION.html The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. 64/83 Gene Ontology BP GO:0006304 0.21248091533213 0.256931834469959 3005 3350.18181818182 3476 0.0214811646251665 2110 0.90423544262595 -0.95211777311882 -1 1.81390488197076 3002 4360 4061 4099 2110 2307 2872 3674 3476 4211 2680 3982 M12690 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. 70/84 Gene Ontology BP GO:0032873 0.168685573205414 0.209920826992456 2180 3126.18181818182 3477 0.0166549454974215 1301 1.03460864105139 1.05894133074841 1 2.38741160116961 2180 4354 3477 4094 2898 3081 1301 3761 3962 3638 1642 3983 M12741 GO_REGULATION_OF_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBRINOLYSIS.html Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. 9/20 Gene Ontology BP GO:0051917 0.0206967375197608 0.0365056556783347 2970 3091.36363636364 3477 0.00208920624620263 1170 1.94052501159437 -1.84357259705429 -1 9.52743488748712 2969 3936 4386 3477 1170 4640 4098 1706 1423 2186 4014 3984 M13229 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter. 27/31 Gene Ontology BP GO:0006356 0.68618940391 0.691390059851284 3480 3091.09090909091 3477 0.1 261 0.889881358789264 0.842655680996787 1 0.476972831011274 3477 1028 3434 1933 3961 4582 4072 3174 261 3657 4423 3985 M12908 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. 44/56 Gene Ontology BP GO:1901021 0.68618940391 0.691390059851284 1975 3247.54545454545 3478 0.1 1974 0.932316916612229 0.910321924684976 1 0.500226590764708 1974 3739 2515 3551 3478 3878 2729 4098 4197 2870 2694 3986 M14839 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 70/84 Gene Ontology BP GO:0070303 0.168685573205414 0.209920826992456 2185 3113.72727272727 3478 0.0166549454974215 1302 1.03460864105139 1.05894133074841 1 2.38741160116961 2181 4355 3478 4095 2899 3082 1302 3614 3963 3639 1643 3987 M14908 GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of cellular protein catabolic process. 315/354 Gene Ontology BP GO:1903362 0.68618940391 0.691390059851284 3985 3096.90909090909 3478 0.1 1322 0.832647114039031 -0.744658911528037 -1 0.445609713725447 3984 1365 4164 1679 3996 2609 3864 3478 1322 4345 3260 3988 M13027 GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION.html Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. 23/34 Gene Ontology BP GO:0060142 0.0109072262412233 0.0220753909092701 3515 3269.81818181818 3479 0.000996516432690495 929 1.07016770350985 -1.10403721219893 -1 6.04872314721586 3514 2777 2341 3919 929 3222 4063 4280 2880 3479 4564 3989 M10176 GO_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 268/308 Gene Ontology BP GO:0007059 0.68618940391 0.691390059851284 2040 3492 3483 0.1 2036 0.812840159100233 -0.87450939961149 -1 0.434755934601925 2036 4289 4201 4298 3605 3145 3483 3362 2558 4417 3018 3990 M11453 GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 9/15 Gene Ontology BP GO:0060456 0.237501956044544 0.284305788905394 2345 3474.54545454545 3483 0.0267512078893593 2141 0.888126637908077 -1.27501636034757 -1 1.64789416883237 2341 4594 4302 4342 2669 3395 2786 2141 4616 3551 3483 3991 M13437 GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. 29/44 Gene Ontology BP GO:0035116 0.00215187803930415 0.00684862415655419 3995 3236.90909090909 3483 0.000195816884979909 281 1.25546268827446 0.8593138125105 1 9.27970882306716 3992 3781 2118 3612 3196 4550 3735 281 3483 3427 3431 3992 M14375 GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 23/26 Gene Ontology BP GO:2001269 0.0364387627475856 0.057827272532236 4325 3601.72727272727 3483 0.00336878886026266 1334 0.898185307223059 -0.798130434076719 -1 3.79063993464401 4323 4497 3276 4437 1334 3457 3993 3332 4348 3483 3139 3993 M15714 GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 250/307 Gene Ontology BP GO:0043244 0.68618940391 0.691390059851284 4270 3190 3483 0.1 1506 1.001248101283 -1.08545978921016 -1 0.537999375902602 4270 2501 3832 1592 3877 4317 3926 3483 1506 2953 2833 3994 M12441 GO_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGY.html The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. 437/578 Gene Ontology BP GO:0006914 0.12213582881354 0.158831193814813 4625 3361.90909090909 3485 0.01177228523337 964 1.0228561776773 -0.994480185858282 -1 2.7837378446131 4625 3281 3660 3485 2463 964 4201 4455 3176 4178 2493 3995 M16157 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. 46/60 Gene Ontology BP GO:0040018 0.68618940391 0.691390059851284 4415 2946.54545454545 3487 0.1 921 1.10366045547661 -1.03690013248126 -1 0.59411911138804 4415 1575 2581 1047 3487 4101 4109 3769 921 2662 3745 3996 M12463 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. 8/12 Gene Ontology BP GO:0032096 0.00189586932095286 0.00630176943628747 4375 2855.09090909091 3490 0.000189748870993634 170 2.42174923890236 -0.626339408747847 -1 18.2094206750419 4372 2912 4370 2541 3771 3605 4320 275 170 3490 1580 3997 M14828 GO_MEMBRANE_HYPERPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_HYPERPOLARIZATION.html The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. 8/21 Gene Ontology BP GO:0060081 0.352318245403383 0.404874486505789 3725 3228.27272727273 3492 0.0425057682924668 1875 1.09851984662901 -0.652039163913543 -1 1.46415602289447 3722 3943 4518 3287 2421 2568 1875 3882 1963 3492 3840 3998 M13388 GO_AMINO_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_METABOLIC_PROCESS.html The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. 34/46 Gene Ontology BP GO:0006040 0.000237552076464117 0.00143923152576502 4575 3005.09090909091 3493 2.15979755265375e-05 205 1.25384717831016 -0.916034675056829 -1 12.1719693812261 4572 3766 2334 3897 205 2750 4531 3493 1348 1834 4326 3999 M15702 GO_NEGATIVE_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APPETITE.html Any process that reduces appetite. 8/12 Gene Ontology BP GO:0032099 0.00203545392634295 0.00659079131473467 4375 2875.18181818182 3493 0.00020373207160187 171 2.42174923890236 -0.626339408747847 -1 18.048170499296 4373 2913 4568 2542 3772 3606 4321 287 171 3493 1581 4000 M16934 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. 8/21 Gene Ontology BP GO:0023019 0.0013450511531245 0.00493185422812315 2965 2974.63636363636 3494 0.000134586597049717 221 2.31047224356079 -2.31047224356079 -1 18.2131330823393 2961 4262 4652 4199 3631 3101 3508 221 2223 3494 469 4001 M15414 GO_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_INVAGINATION.html The infolding of a membrane, resulting in formation of a vesicle. 41/170 Gene Ontology BP GO:0010324 0.0172739992908603 0.0316689986999105 3740 3074.90909090909 3495 0.00158283104711799 1070 1.19839558701453 1.07874375572865 1 6.1326154256498 3740 4066 1906 2646 1070 3495 3521 3424 4019 1321 4616 4002 M15870 GO_CELLULAR_MACROMOLECULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULE_LOCALIZATION.html Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 1320/1626 Gene Ontology BP GO:0070727 0.440240522899411 0.490127456186786 4495 3532 3495 0.0563734635385826 2222 0.943626673683831 -0.92351404481478 -1 0.98846534513296 4495 3615 4578 3406 2945 2564 4614 3495 2515 4403 2222 4003 M12896 GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. 226/332 Gene Ontology BP GO:0043903 0.580212854407721 0.627698305407841 4605 3548.63636363636 3496 0.0758766975509221 1372 1.04262821025024 -0.920294213199439 -1 0.710292607392355 4605 3968 3496 4370 2705 3393 4555 3936 1372 3397 3238 4004 M16753 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. 12/16 Gene Ontology BP GO:2000727 0.424799924770398 0.476058297195728 4005 3445.90909090909 3498 0.0490331945928729 1831 1.25857737115331 1.38633017548834 1 1.37636884713326 4001 3925 2748 4073 4128 1831 2531 3498 4622 3205 3343 4005 M10424 GO_RIBOSOME_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. 326/424 Gene Ontology BP GO:0042254 0.379037262850794 0.431846323223492 860 3310 3500 0.0423919762636285 856 0.640196237452299 0.594326101210765 1 0.787527649773155 856 4635 4202 4646 2697 2640 1874 2613 4299 4448 3500 4006 M11148 GO_OXIDATIVE_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. 9/41 Gene Ontology BP GO:0070989 0.039659861313472 0.0618422703390031 3470 2871.72727272727 3500 0.00403859745588417 600 2.02417381848764 -2.30399181805524 -1 8.35429939271812 3470 3937 4280 3500 3566 758 600 3956 804 2184 4534 4007 M14335 GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 18/39 Gene Ontology BP GO:0051350 0.223837117972081 0.269473249656945 3950 3418.36363636364 3500 0.0227724199815083 1499 1.57086275093695 -1.5268527744668 -1 3.04786515193389 3950 3842 1499 3217 4296 3500 4010 3390 4204 2651 3043 4008 M10482 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. 18/23 Gene Ontology BP GO:0045603 0.0605761010191072 0.0877523655174053 3720 3110.27272727273 3502 0.00566466448733327 1452 1.60617214631761 1.05060219442364 1 5.79234478863309 3716 3866 1452 3998 1520 3460 3502 4018 2992 1593 4096 4009 M12323 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of striated muscle contraction. 18/27 Gene Ontology BP GO:0045989 0.154430035118972 0.194627018799722 4540 3208 3502 0.0151338030219986 995 1.39142384547763 -1.45125141150423 -1 3.37074362340472 4494 3533 1388 3268 4539 3502 4549 4540 995 1185 3295 4010 M14248 GO_RESPONSE_TO_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TEMPERATURE_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. 185/246 Gene Ontology BP GO:0009266 0.000333986657436849 0.00184346372129734 3760 3005.54545454545 3502 3.0367033767027e-05 422 1.27372234306345 -1.267261754983 -1 11.8969234797611 3760 2527 422 2339 3502 4350 4127 4001 2935 603 4495 4011 M14208 GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. 16/24 Gene Ontology BP GO:0002381 0.368265416286853 0.421431131820641 3730 3491.90909090909 3503 0.0408936052921585 2371 0.904886404504243 0.792058803138712 1 1.15034267831082 3728 3881 3350 3557 3414 3572 3292 2371 3286 3503 4457 4012 M16360 GO_CELLULAR_GLUCURONIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCURONIDATION.html The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. 4/23 Gene Ontology BP GO:0052695 0.00158844930638506 0.0055823675397354 1190 2837.72727272727 3503 0.000158958587700159 242 2.10465117332688 2.10465117332688 1 16.2025370222961 1186 3950 4617 3690 4435 3850 1211 242 3503 3028 1503 4013 M16350 GO_RESPONSE_TO_WATER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. 21/31 Gene Ontology BP GO:0009415 0.000211652567405986 0.00132013323879364 3895 2857.90909090909 3504 1.92429938486355e-05 192 1.23968105772387 1.19856529990097 1 12.1933233220661 3893 3504 1522 3723 192 4363 2670 1134 4298 1948 4190 4014 M11667 GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 395/602 Gene Ontology BP GO:0045088 0.68618940391 0.691390059851284 4005 3196.63636363636 3505 0.1 626 1.03125894189024 1.04290029846601 1 0.554444661726131 4005 626 2364 1828 4243 3994 4030 4493 3046 3029 3505 4015 M12296 GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. 14/21 Gene Ontology BP GO:0048714 0.0908141927821062 0.123374726719749 4265 3444.81818181818 3506 0.00861772516870145 1699 1.39899890908455 1.66750243201268 1 4.33609653144315 4262 3568 2207 3401 1699 3506 3450 2929 4413 3848 4610 4016 M16116 GO_PEPTIDYL_METHIONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_METHIONINE_MODIFICATION.html The modification of peptidyl-methionine. 10/12 Gene Ontology BP GO:0018206 0.384241701670016 0.436493319792623 2685 3265.27272727273 3506 0.0431244021282933 2246 0.535774053900318 0.535774053900318 1 0.648820279982072 2684 2396 3738 3327 2408 3786 3506 3520 2246 4625 3682 4017 M12352 GO_CENTRIOLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE_ASSEMBLY.html A cellular process that results in the assembly of one or more centrioles. 20/27 Gene Ontology BP GO:0098534 0.0331843248839267 0.0533909625466497 2765 3381.81818181818 3508 0.0030632456490722 1313 0.578073064466119 -0.619670383238275 -1 2.50437176998877 2765 3508 3859 3974 1313 3389 4126 3979 3054 4508 2725 4018 M13660 GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. 60/88 Gene Ontology BP GO:1901222 0.0535906028253375 0.0791358536801952 470 2740.18181818182 3508 0.00499476058017921 467 0.960692397406678 0.949574694463371 1 3.60769271106804 467 4373 3508 4634 3811 599 726 2052 3871 4086 2015 4019 M15308 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of magnesium ion across a membrane. 17/18 Gene Ontology BP GO:1903830 0.142058050422769 0.180550698884771 4380 2950.45454545455 3508 0.013832425947517 453 0.86794019445635 -1.04177928718417 -1 2.19533598984826 4379 453 2902 1220 1904 3841 3862 3957 3508 2558 3871 4020 M16613 GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. 20/21 Gene Ontology BP GO:0034616 0.00531823662945499 0.0131766533742567 4550 3409.09090909091 3509 0.000484648773498657 747 1.16723781797341 -0.977984230357012 -1 7.49267737007711 4549 3509 2814 3162 747 4189 4510 2993 4285 2362 4380 4021 M16854 GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY.html Any process that modulates the activity of the enzyme protein phosphatase type 2A. 23/25 Gene Ontology BP GO:0034047 0.68618940391 0.691390059851284 3830 3253.27272727273 3512 0.1 274 0.781327494638849 -0.457655294748955 -1 0.417487682075761 3512 3483 3830 2700 3449 3877 3718 3844 274 3828 3271 4022 M15146 GO_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. 973/1375 Gene Ontology BP GO:0061024 0.504265886791227 0.554037584708283 4020 3609.27272727273 3513 0.067766123948128 2592 0.975966623577363 -0.96238968550677 -1 0.845090063912699 4020 2937 4537 2805 2640 4405 3513 4558 2592 4273 3422 4023 M14731 GO_BEHAVIORAL_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_COCAINE.html Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. 8/15 Gene Ontology BP GO:0048148 0.00372379720423044 0.0102525611782747 1790 2953.90909090909 3514 0.00037300519600506 393 1.4191023079063 1.4191023079063 1 9.64045262058718 1787 3942 4515 3756 1028 4510 3514 393 4427 2753 1868 4024 M10103 GO_REGULATION_OF_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GOLGI_ORGANIZATION.html Any process that modulates the frequency, rate or extent of Golgi organization. 19/19 Gene Ontology BP GO:1903358 0.68618940391 0.691390059851284 3850 3412.90909090909 3517 0.1 267 0.816320273978405 -0.496632473590758 -1 0.436662961619903 3846 3517 3500 3131 3467 3770 4566 3270 267 3645 4563 4025 M13161 GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 20/21 Gene Ontology BP GO:0002183 0.00155643009608913 0.0054864160887142 2580 2956.90909090909 3521 0.000141593846616229 467 0.651177027151713 -0.776174562981678 -1 5.02244914823151 2576 3521 3863 3135 467 3653 2576 3768 1194 4050 3723 4026 M10625 GO_POSITIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RNA_SPLICING.html Any process that activates or increases the frequency, rate or extent of RNA splicing. 30/44 Gene Ontology BP GO:0033120 0.0741476392326773 0.103824545696554 4360 3332.63636363636 3522 0.00697921271375694 1462 0.845829685143935 -0.931985529581508 -1 2.8340472271316 4357 3789 3476 3440 1895 2913 3522 1462 4471 3778 3556 4027 M14420 GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION.html A cardiac conduction process that modulates the frequency or rate of heart contraction. 37/62 Gene Ontology BP GO:0086091 0.00224737544104747 0.00706556616702291 3375 3272.72727272727 3522 0.000204515863708581 586 1.35246193951561 -1.6072341803563 -1 9.93487352461615 3374 3405 586 3935 4319 3522 4068 1958 4173 2436 4224 4028 M10819 GO_ACTIN_MYOSIN_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MYOSIN_FILAMENT_SLIDING.html The sliding movement of actin thin filaments and myosin thick filaments past each other. 30/58 Gene Ontology BP GO:0033275 0.0395048213026378 0.0617039872824893 3990 3148.72727272727 3523 0.00365750555082751 1363 1.20808992392065 -1.4331536726969 -1 4.98582252106724 3986 3783 2146 3523 1363 3477 4535 2411 3566 1902 3944 4029 M12638 GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0034030 0.384527675688772 0.436711563334112 4135 3381.18181818182 3523 0.043164810448548 1575 0.706854811045642 0.830891034674177 1 0.858878538624154 4133 2338 3513 3276 4348 3523 4169 2405 1575 3909 4004 4030 M15962 GO_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_MEDIATED_ENDOCYTOSIS.html An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. 42/51 Gene Ontology BP GO:0072583 0.0174185933122963 0.0318540966204779 4545 2485.90909090909 3523 0.00159618673596418 213 0.887244575117691 0.964599078755933 1 4.52989930380247 4541 213 3523 419 1075 4093 3984 3654 602 3663 1578 4031 M13640 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0034033 0.368635291764535 0.421655146183072 4135 3379.54545454545 3524 0.0409446687941101 1576 0.706854811045642 0.830891034674177 1 0.895702479287679 4134 2339 3514 3277 4349 3524 4170 2374 1576 3913 4005 4032 M14866 GO_MUSCLE_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FILAMENT_SLIDING.html The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. 30/58 Gene Ontology BP GO:0030049 0.0395048213026378 0.0617039872824893 3990 3148.18181818182 3524 0.00365750555082751 1364 1.20808992392065 -1.4331536726969 -1 4.98582252106724 3987 3784 2147 3524 1364 3478 4536 2392 3567 1906 3945 4033 M14952 GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0033866 0.385569284699331 0.437467418118993 4135 3384.18181818182 3525 0.0433121349466427 1577 0.706854811045642 0.830891034674177 1 0.857063545196023 4135 2340 3515 3278 4350 3525 4171 2410 1577 3919 4006 4034 M15090 GO_REGULATION_OF_CHOLESTEROL_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_STORAGE.html Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 20/23 Gene Ontology BP GO:0010885 0.236697834658807 0.283463971917208 3865 3316.54545454545 3525 0.0242556505723615 1590 1.53248750317523 -1.59478683660423 -1 2.85797147227206 3863 3525 2270 3530 2546 3318 4222 4552 4237 2829 1590 4035 M11879 GO_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 40/48 Gene Ontology BP GO:0032069 0.0154489563964521 0.028985481497053 4045 3242 3527 0.00141441105023717 1036 0.719996530509028 -0.742895491013143 -1 3.77488022035418 3121 2682 3527 3667 1036 3176 4041 3551 4513 4041 2307 4036 M12729 GO_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. 845/1026 Gene Ontology BP GO:0009894 0.6513215599 0.691390059851284 3145 3140.45454545455 3528 0.1 586 0.928201465150538 1.00370319124847 1 0.497971413161851 3142 586 4383 672 3355 4651 3528 4117 1737 4210 4164 4037 M14625 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION.html A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. 43/47 Gene Ontology BP GO:0033683 0.273781971306919 0.322916986689757 4065 3302.72727272727 3529 0.028663452818923 1928 0.646312611191073 -0.669041501306347 -1 1.07410344576286 1928 4064 4024 4062 2222 1946 2930 3529 4178 4303 3144 4038 M16330 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 24/38 Gene Ontology BP GO:0035774 0.0755663169521799 0.105461929447658 2820 3459.45454545455 3530 0.00711763637730739 1471 0.968145046063439 1.14302413192491 1 3.22292657079345 2819 4487 3165 4542 4138 4452 3201 1471 4342 3530 1907 4039 M10804 GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 13/15 Gene Ontology BP GO:0044090 0.0375630285620479 0.0592678100709422 3640 2753.54545454545 3531 0.00347455871883577 1059 0.924816459863774 0.986637011093717 1 3.86955978922918 3637 1200 3531 2421 3916 4254 3893 1138 1059 3805 1435 4040 M13500 GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 24/29 Gene Ontology BP GO:0030206 0.015412982873841 0.0289296528083833 2325 3128.36363636364 3531 0.00141109416743509 1034 1.35384299436219 -1.11187610594702 -1 7.11134552803345 2321 4489 1777 4311 1034 4450 3942 2890 3886 1781 3531 4041 M15072 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. 17/39 Gene Ontology BP GO:0046636 0.0474426406684947 0.0713710336341759 3745 3367.09090909091 3531 0.00440888439138246 1441 0.920503142568304 -1.09930635903145 -1 3.59747761721598 3743 3531 3124 3317 1441 3922 4487 4055 2549 3076 3793 4042 M16028 GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of embryonic development. 31/48 Gene Ontology BP GO:0040019 0.248450969863112 0.296269185743993 1915 3246.63636363636 3531 0.0256311472253653 1555 1.1435602715306 -1.3309709374358 -1 2.05492286490739 1914 4440 2627 4540 3531 2050 1555 4489 4167 3820 2580 4043 M16190 GO_PROTEIN_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HYDROXYLATION.html The addition of a hydroxy group to a protein amino acid. 17/20 Gene Ontology BP GO:0018126 0.68618940391 0.691390059851284 3475 3091.90909090909 3534 0.1 259 1.43988951630571 -1.21929450792295 -1 0.778365300286053 3471 4187 2410 2120 3534 4357 4076 3563 259 2045 3989 4044 M12682 GO_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 97/115 Gene Ontology BP GO:0051983 0.20101951909827 0.244726274820578 3535 3123.45454545455 3535 0.0201949990318838 835 0.916985213360851 -0.939171050113603 -1 1.90589950605846 3535 2075 4011 1418 2079 4647 4430 3791 835 4124 3413 4045 M12606 GO_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR.html The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 499/574 Gene Ontology BP GO:0006281 0.330082645978119 0.382490829178694 2220 3364.09090909091 3536 0.0357630984215342 1596 0.761650671798694 -0.799292135243538 -1 1.07621029490907 2218 4282 4210 4494 3536 1596 3215 3008 3812 4515 2119 4046 M16625 GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that modulates the frequency, rate or extent of viral release from host cell. 39/50 Gene Ontology BP GO:1902186 0.0142566364533357 0.0271758006625854 2870 3217.09090909091 3538 0.00130453368581673 758 0.895672426729162 -1.00311488576437 -1 4.78427316805916 2868 4086 3420 4044 4056 2637 3538 758 3869 3818 2294 4047 M13364 GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. 33/41 Gene Ontology BP GO:0048485 0.127447704853685 0.164589001022536 2530 3236.45454545455 3540 0.0123173930483498 1759 1.39557863232278 1.68685105613589 1 3.72821020766176 2526 4452 1957 4460 2556 3540 2496 1759 4223 3580 4052 4048 M16089 GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. 106/204 Gene Ontology BP GO:0002698 0.078504735299508 0.108909520974541 3960 3096.63636363636 3543 0.00740495996063685 873 1.04901644873275 -0.928831799112749 -1 3.44293145270373 3956 1464 1827 2312 3543 4395 4006 2836 4221 873 4630 4049 M12696 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 15/15 Gene Ontology BP GO:0032968 0.68618940391 0.691390059851284 3735 3190.72727272727 3544 0.1 536 0.65278159850891 0.546754388847503 1 0.347047335836745 3735 2831 3796 2175 4451 2961 3029 3544 536 3877 4163 4050 M13670 GO_PIGMENT_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. 24/29 Gene Ontology BP GO:0048753 0.554657131789879 0.603700499232352 3105 2891.36363636364 3544 0.0708985528367519 740 0.919992751746801 -0.737942203511907 -1 0.678742699672255 3103 1053 3546 1915 3544 3650 3554 4427 740 3858 2415 4051 M16099 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 16/30 Gene Ontology BP GO:0055015 0.0048891340422138 0.0123973518792484 3545 3137.36363636364 3544 0.000445457568619554 431 1.21224491797255 1.29923356579046 1 7.89172921501483 3565 3545 2846 2941 3640 3598 3544 431 3512 3923 2966 4052 M15179 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 17/18 Gene Ontology BP GO:0045717 9.97722370242787e-05 0.000745168890648425 3865 3189.09090909091 3545 9.07061473490765e-06 138 0.704221586484469 0.616178779064904 1 7.51999879036356 3865 2318 3410 2117 138 3609 3045 4617 3817 4599 3545 4053 M12473 GO_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BUDDING.html The evagination of a membrane, resulting in formation of a vesicle. 153/170 Gene Ontology BP GO:0006900 0.000357027655051912 0.00192051986006537 3815 2922.54545454545 3546 3.24623280507861e-05 252 0.913830911822609 -0.786220554398758 -1 8.47686002622653 3811 1424 3616 1115 252 3397 4023 4614 2164 4186 3546 4054 M14725 GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to another cell. 209/357 Gene Ontology BP GO:0022409 0.000733257962804709 0.00319461545030928 3725 2864.18181818182 3546 6.66820428276792e-05 475 1.26143208942449 -1.28025486546543 -1 10.7522057578269 3723 2515 475 1040 3663 4501 3546 4186 3437 599 3821 4055 M15611 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 40/48 Gene Ontology BP GO:0050654 0.0125783622936977 0.0246326261584913 3550 3055.54545454545 3546 0.00115007811421517 975 1.31434191287593 -1.1719316286758 -1 7.21735061570725 3546 2679 1142 2974 975 3742 4164 4207 4189 1926 4067 4056 M10313 GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. 49/55 Gene Ontology BP GO:0031122 0.174564117370721 0.216138062300683 4375 3091 3547 0.0172891330502595 1389 0.940402999275851 -1.14759427472347 -1 2.12830160066292 4374 3733 3788 2461 3915 3228 1392 3547 2311 3863 1389 4057 M12907 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. 16/16 Gene Ontology BP GO:0070198 0.246308899849038 0.294032515888264 2750 3378.63636363636 3547 0.0253790053051649 2117 0.554595198630521 0.609309707877311 1 0.997329727436329 2749 3547 3776 4019 2491 3339 2986 2117 3916 4525 3700 4058 M15352 GO_TROPHECTODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHECTODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. 10/14 Gene Ontology BP GO:0001829 0.0156404201084659 0.0292380457037111 4195 3238 3548 0.00143206651844374 316 1.225283748251 -1.225283748251 -1 6.41575680980124 4194 3926 2951 3548 4499 4408 2660 4309 1785 3022 316 4059 M15852 GO_POSITIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AUTOPHAGY.html Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 98/126 Gene Ontology BP GO:0010508 0.43119990772354 0.48137552078638 3600 2999.81818181818 3548 0.05 49 0.906598688277977 0.920037192638543 1 0.97351404713173 3598 49 3548 1386 3904 4150 4189 2641 2185 3511 3837 4060 M11423 GO_REGULATION_OF_DOPAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of dopamine. 15/27 Gene Ontology BP GO:0014059 0.68618940391 0.691390059851284 3595 3373.90909090909 3549 0.1 1620 1.33730726596986 -1.27053668536258 -1 0.722152465421765 3591 3549 2504 3494 3684 4590 2691 4330 1620 2907 4153 4061 M12792 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. 45/56 Gene Ontology BP GO:0010882 0.68618940391 0.691390059851284 3000 3499 3549 0.1 2664 0.76794942492886 -0.713212169993971 -1 0.410156791780914 3000 2664 2726 4520 3401 3553 3007 4249 4050 3770 3549 4062 M13819 GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that activates or increases the frequency, rate or extent of chromatin modification. 97/111 Gene Ontology BP GO:1903310 0.621416493497997 0.667463283528666 2480 3427.45454545455 3549 0.0845153588031286 2397 1.02318868609496 0.960115890584506 1 0.603530365562238 2477 4339 3665 4299 3335 2423 2397 3549 4113 3634 3471 4063 M16234 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 449/537 Gene Ontology BP GO:0010639 0.333710087676566 0.385777152287966 3550 3379.90909090909 3549 0.0362389171809566 1890 0.966535379117471 -1.01508208308738 -1 1.35630218997143 3549 4283 4097 3149 4049 2606 4203 2349 2967 4037 1890 4064 M15038 GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. 46/69 Gene Ontology BP GO:0048483 0.0253409890678475 0.0430963531186748 2530 3175.09090909091 3552 0.00233069801685906 950 1.47329621024741 1.80316155475879 1 6.86782725732394 2527 4384 950 3399 3578 3635 2999 3552 3782 2333 3787 4065 M15760 GO_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 646/808 Gene Ontology BP GO:0010564 0.588191537204498 0.635258837138966 3555 3273.81818181818 3552 0.0848979532163908 1621 0.970861465948338 -0.917733833305144 -1 0.643407735890436 3552 1901 4570 2933 4329 2788 4054 3576 1621 4128 2560 4066 M13803 GO_COENZYME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 123/138 Gene Ontology BP GO:0009108 0.68618940391 0.691390059851284 3555 3162.90909090909 3553 0.1 759 0.922674220154366 1.067903444828 1 0.49494260350709 3553 759 3280 1450 4090 4328 4359 3760 2339 2756 4118 4067 M16816 GO_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_SPLICING.html Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 113/150 Gene Ontology BP GO:0043484 0.68618940391 0.691390059851284 2095 3481.45454545455 3553 0.1 2092 0.771395435531525 -0.911334295975247 -1 0.412045130400061 2092 3670 4073 3453 3237 2893 2654 4083 3553 4313 4275 4068 M11669 GO_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. 1236/1788 Gene Ontology BP GO:0016192 0.00525070999993344 0.0130510436056038 3560 2776.54545454545 3556 0.000526315789473684 56 1.09625673565972 -1.07891816879751 -1 7.0519819927779 3556 572 4319 56 1632 4129 3702 4508 2086 2057 3925 4069 M16342 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM.html Any process that modulates the frequency, rate or extent of defense response to bacterium. 9/15 Gene Ontology BP GO:1900424 0.590172123991604 0.636991624433526 3940 3372.72727272727 3556 0.0853390256521144 2199 0.755148751443729 -0.894029999249928 -1 0.495027531939125 3936 2407 4615 2443 4143 2199 2903 3896 3110 3556 3892 4070 M15918 GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. 9/13 Gene Ontology BP GO:0002320 0.0153872867502269 0.0288930771786948 3560 2939.54545454545 3557 0.0015494882660856 676 1.56684429135242 -1.05643141553791 -1 8.23480053000628 3557 4587 4581 2900 1329 4203 3630 800 676 2188 3884 4071 M16168 GO_PROTEIN_LIPID_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_REMODELING.html The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. 14/28 Gene Ontology BP GO:0034368 0.0228087602500734 0.0394385586932708 4105 2843 3557 0.00209533846002548 558 1.80445839111388 -2.16362940464419 -1 8.65158942629002 4104 3218 932 2783 3616 4169 3969 3557 558 773 3594 4072 M11832 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS.html The somatic process that results in the generation of sequence diversity of immunoglobulins. 25/29 Gene Ontology BP GO:0016445 0.68618940391 0.691390059851284 3575 3424.18181818182 3560 0.1 1755 0.852295826625987 -0.888438040718352 -1 0.456376779492969 3573 3476 3585 3084 2950 3886 4607 3706 1755 3560 3484 4073 M12154 GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. 19/32 Gene Ontology BP GO:0048026 0.372567428312094 0.425621469171661 4275 3633.36363636364 3561 0.0414892113914894 2386 0.689352129867837 -0.771390154409827 -1 0.863676377309415 4271 3862 3364 3846 2386 3377 3355 3309 4612 4024 3561 4074 M14867 GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). 14/28 Gene Ontology BP GO:0034369 0.0228087602500734 0.0394385586932708 4105 2842.45454545455 3562 0.00209533846002548 557 1.80445839111388 -2.16362940464419 -1 8.65158942629002 4103 3217 931 2782 3615 4168 3968 3562 557 771 3593 4075 M12375 GO_SYNAPTIC_VESICLE_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_ENDOCYTOSIS.html Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished. 20/27 Gene Ontology BP GO:0048488 0.297049431767069 0.348417193348165 3540 3384.54545454545 3563 0.0315346846758172 992 1.01471068985095 0.959902818655662 1 1.57790484789839 3540 3824 3563 4150 4482 4393 3706 2233 992 3324 3023 4076 M13282 GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition. 179/212 Gene Ontology BP GO:1902806 0.68618940391 0.691390059851284 4485 3314.81818181818 3564 0.1 1004 1.06411270448164 -0.952885189384517 -1 0.572447806765109 4483 2002 3210 2377 3725 4375 4114 4152 1004 3457 3564 4077 M14367 GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING.html The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. 27/28 Gene Ontology BP GO:0051084 0.544655839029722 0.593787164715393 3180 3560.90909090909 3566 0.0690207974159003 2230 0.608419226545639 -0.581089217568037 -1 0.460219894819015 3176 4482 3566 4286 3627 2604 2230 2848 4647 4574 3130 4078 M16612 GO_REGULATION_OF_GONADOTROPIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GONADOTROPIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. 6/14 Gene Ontology BP GO:0032276 0.0926994844744709 0.125532800133793 2690 3495.81818181818 3566 0.00968099002473262 991 0.991266173091724 -1.59566783784311 -1 3.04372736323976 2688 3609 4640 3566 4585 3549 991 4205 4068 3310 3243 4079 M12571 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. 32/32 Gene Ontology BP GO:0006359 0.149907699968382 0.18944066484326 3205 3300 3567 0.0146561150980208 1215 0.805683935633146 -0.678595472587247 -1 1.97960304543564 3204 3773 3567 4242 3356 1638 1215 3970 4250 4081 3004 4080 M10212 GO_VIRAL_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_BUDDING.html A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. 25/25 Gene Ontology BP GO:0046755 0.0276104357456598 0.0462793074656178 3320 3071.81818181818 3568 0.00254210595725169 984 0.623677963955747 -0.647321759979359 -1 2.83516243050748 3319 4132 3982 3635 1751 2756 3952 984 3568 4446 1265 4081 M16672 GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. 25/37 Gene Ontology BP GO:0032897 0.00893014693869528 0.0188872607753405 2775 3173.72727272727 3568 0.000815145741503421 880 0.850810858908515 0.618433059000207 1 5.00375064097817 2775 4155 3271 3583 880 2972 1699 3913 3901 3568 4194 4082 M13432 GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION.html An organelle organization which involves another organism. 25/25 Gene Ontology BP GO:1902590 0.0487990519516934 0.0730102857656686 3320 3107 3569 0.0045378487934529 1262 0.623677963955747 -0.647321759979359 -1 2.4129686236946 3320 4133 3983 3636 1752 2757 3953 1262 3569 4546 1266 4083 M15650 GO_MULTI_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves another organism. 25/25 Gene Ontology BP GO:1902592 0.0751683799036206 0.10496345506116 3325 3132.45454545455 3570 0.0070787892630629 1267 0.623677963955747 -0.647321759979359 -1 2.07679936046298 3321 4134 3984 3637 1753 2758 3954 1467 3570 4612 1267 4084 M12576 GO_MACROMOLECULAR_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_REMODELING.html The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. 14/28 Gene Ontology BP GO:0034367 0.0228087602500734 0.0394385586932708 4105 2842.54545454545 3573 0.00209533846002548 556 1.80445839111388 -2.16362940464419 -1 8.65158942629002 4102 3216 930 2781 3614 4167 3967 3573 556 770 3592 4085 M13931 GO_REGULATION_OF_PROTEIN_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_STABILITY.html Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. 252/304 Gene Ontology BP GO:0031647 0.169152486568743 0.210445593584053 4265 3417.36363636364 3573 0.0167051676287623 1992 0.949750369839329 -0.866430793512791 -1 2.18720140054787 4265 3287 3929 2949 1992 2222 4008 3781 3392 4193 3573 4086 M16000 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 506/975 Gene Ontology BP GO:0050778 0.0450603133310679 0.0682727573850404 3620 2934.27272727273 3573 0.00460009657762972 604 1.14360547254369 1.16535534763933 1 4.54734458457779 3620 604 4585 750 3573 4302 3503 3617 2663 789 4271 4087 M16418 GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 30/30 Gene Ontology BP GO:0051984 0.68618940391 0.691390059851284 4305 3017.72727272727 3573 0.1 202 1.18851215102571 1.10637003840631 1 0.640615989105591 4304 1647 3484 1394 2925 3765 3573 3636 202 4035 4230 4088 M11448 GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. 45/68 Gene Ontology BP GO:0003254 0.00159111559680959 0.00558751763921134 3710 3283.45454545455 3574 0.000144751592072689 542 1.34469593024568 -1.18579784751311 -1 10.3463735994996 3706 3386 542 3970 4206 3919 4626 2444 3574 2276 3469 4089 M12235 GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. 19/19 Gene Ontology BP GO:0031065 0.699708374776107 0.704553790918249 3875 3629.54545454545 3574 0.103595704180546 2418 0.842574310534497 -0.759421544653878 -1 0.427453574994215 3872 4545 3402 4617 3542 2418 3574 2925 4615 3647 2768 4090 M14802 GO_ACETYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. 11/12 Gene Ontology BP GO:0006085 3.43714887925869e-05 0.000335904000263133 3775 3076.36363636364 3575 3.12472961854438e-06 78 0.724584727352615 0.886073555519425 1 8.59500365726783 3775 1849 3561 3575 78 4601 4464 1768 2574 3678 3917 4091 M14472 GO_NUCLEAR_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_IMPORT.html The directed movement of substances into the nucleus. 137/180 Gene Ontology BP GO:0051170 0.68618940391 0.691390059851284 3160 3604.72727272727 3579 0.1 2798 0.89832084798572 -0.791770229444348 -1 0.48159748694333 3158 4309 3994 3876 3310 3579 2798 3201 3074 4073 4280 4092 M13693 GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that activates or increases the frequency, rate or extent of receptor internalization. 20/32 Gene Ontology BP GO:0002092 0.68618940391 0.691390059851284 3040 3547 3581 0.1 2163 1.50041505858472 1.23640811291304 1 0.811531976802338 3038 4509 2163 4171 3558 4567 3617 3379 4078 2356 3581 4093 M14220 GO_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_METHYLATION.html The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. 33/38 Gene Ontology BP GO:0051568 0.68618940391 0.691390059851284 2695 3567.63636363636 3582 0.1 2693 1.44621378154592 -2.10411761541957 -1 0.78183085964376 2758 3438 3471 3856 4344 2693 2695 4287 3693 3582 4427 4094 M14809 GO_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 141/173 Gene Ontology BP GO:0071156 0.115280940768106 0.151014137779842 3585 3282.81818181818 3582 0.0110732471780383 1695 0.970126793732271 -0.873668649556972 -1 2.71238189340703 3582 2547 3725 4194 3031 3696 2851 1695 2294 3947 4549 4095 M16076 GO_POSITIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the cell cycle. 394/497 Gene Ontology BP GO:0045787 0.68618940391 0.691390059851284 3775 3304.09090909091 3582 0.1 1352 1.04058775193731 -1.05833685263181 -1 0.559556646079558 3774 1352 3582 3408 4165 3447 3032 3777 2263 3789 3756 4096 M12149 GO_NEGATIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 58/67 Gene Ontology BP GO:0010507 0.594472065162403 0.64133515399969 3310 3472.27272727273 3584 0.0787754033426561 2346 0.83657109842052 -0.736808998651732 -1 0.541111181035811 3308 3354 3584 4266 4246 2476 2346 3602 4313 4163 2537 4097 M15043 GO_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. 630/813 Gene Ontology BP GO:0016071 0.332392913616172 0.384732394790062 1305 3562.09090909091 3584 0.0396001273668243 1304 0.765913598883933 0.722307519661642 1 1.07564813418519 1304 4620 4533 4648 4270 2724 1826 3524 3557 4593 3584 4098 M15126 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. 33/42 Gene Ontology BP GO:1901797 0.270935175022169 0.319746351886674 3565 3452.45454545455 3584 0.0283179164166822 2220 1.17458904662622 -0.986512863071138 -1 1.97796773543749 3561 3772 2673 3769 2220 3210 3217 3923 3820 3584 4228 4099 M11964 GO_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PROCESSING.html Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. 857/1051 Gene Ontology BP GO:0006396 0.6513215599 0.691390059851284 1905 3659.18181818182 3586 0.1 1904 0.734969389614901 0.691846002470183 1 0.392084452045215 1904 4617 4335 4652 3097 3430 2643 3440 3586 4493 4054 4100 M16277 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. 32/34 Gene Ontology BP GO:0000291 0.149317488843075 0.188797357496421 2720 3211.45454545455 3586 0.0145939424405465 1921 0.558418454921602 -0.558418454921602 -1 1.37160826875083 2716 2219 4065 3623 1921 2285 2740 3880 3660 4631 3586 4101 M10948 GO_ROUNDABOUT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUNDABOUT_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 11/15 Gene Ontology BP GO:0035385 0.0278379738301492 0.0465433317397356 4565 3192.63636363636 3588 0.00256332676409415 1232 1.46279177483082 1.37805043724158 1 6.6516592930421 4565 3588 1718 3946 1232 3692 3598 3383 4308 1799 3290 4102 M10609 GO_SODIUM_ION_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_EXPORT.html The directed movement of sodium ions out of a cell or organelle. 10/15 Gene Ontology BP GO:0071436 0.00524305789087467 0.0130510436056038 3745 3045.72727272727 3589 0.000477781367196217 450 2.00650484775871 -2.19352583847894 -1 12.9162643476615 3745 4248 1625 4500 2369 4419 3589 450 1704 3013 3841 4103 M11392 GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE.html A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. 22/27 Gene Ontology BP GO:0035584 0.74713067618015 0.751328946675219 4425 3614.09090909091 3589 0.117493665104206 2093 0.755541746900389 -0.724807426981841 -1 0.310087613823312 4424 3149 2093 4156 3589 3271 4027 3128 4641 3420 3857 4104 M16696 GO_CENTROSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_LOCALIZATION.html Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. 31/32 Gene Ontology BP GO:0051642 0.330314047636065 0.382611716119146 2640 3377.90909090909 3589 0.0357933818121473 1762 0.871878931604437 0.63466252947521 1 1.23309656958659 2640 3777 3589 4246 2926 3007 1762 4103 3653 4064 3390 4105 M16248 GO_NEGATIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_KILLING.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. 36/80 Gene Ontology BP GO:0031342 0.745220793596773 0.749570331302591 2995 3547.72727272727 3590 0.116889787014337 2445 0.922233495144288 -0.755892500479963 -1 0.38406228950398 2994 4089 2510 3590 4058 2445 3884 4395 4638 3112 3310 4106 M13478 GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY.html Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. 18/26 Gene Ontology BP GO:0001539 0.68618940391 0.691390059851284 3595 3343.27272727273 3592 0.1 1926 1.40835719082104 -1.35159218309727 -1 0.76108627394813 3592 2305 2127 2759 4248 4424 3851 3910 1926 3147 4487 4107 M14912 GO_TETRAHYDROFOLATE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_INTERCONVERSION.html The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. 12/13 Gene Ontology BP GO:0035999 0.416639976079772 0.468267103550526 2110 3337.90909090909 3592 0.0478146068133073 1932 0.786858167659347 -0.800964160174678 -1 0.875784037263358 2110 4244 3635 3987 3759 1932 1958 3561 3592 4588 3351 4108 M11511 GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 47/83 Gene Ontology BP GO:0048260 0.526171701148457 0.575929646070047 2655 3501.63636363636 3593 0.0656469673386376 2438 1.34495944192635 1.36582238191274 1 1.09124141080997 2651 4379 2438 3832 3593 4556 4258 2651 4170 3038 2952 4109 M15202 GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. 40/58 Gene Ontology BP GO:1901862 0.178355132455409 0.220245868183392 4535 3231.63636363636 3593 0.0177002956349856 1400 1.23932413664344 -1.24227632234477 -1 2.77355795529247 4532 3748 1550 3067 3635 3370 4295 3593 4075 2283 1400 4110 M12165 GO_HYPOTHALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPOTHALAMUS_DEVELOPMENT.html The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. 18/35 Gene Ontology BP GO:0021854 0.00971041607681138 0.0201460916447987 3890 3234.09090909091 3594 0.000886685717381408 901 1.04671100112152 1.20068651519044 1 6.05804456043023 3888 3181 2365 2659 901 4267 3770 2272 4489 3594 4189 4111 M15118 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. 71/84 Gene Ontology BP GO:0045669 0.00645446885731848 0.0146439813977582 3595 2895.90909090909 3594 0.000588498494883162 723 1.56044014641114 1.66482827616715 1 9.7756607080637 3594 4024 723 3752 2928 4208 3890 2753 1193 803 3987 4112 M13137 GO_AMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 505/656 Gene Ontology BP GO:0043604 0.599628755530086 0.64570137081094 3595 3507.18181818182 3595 0.0874718138881323 1455 0.95531082712873 -0.881544664147979 -1 0.609803614370192 3595 4281 4409 4277 2859 3116 3811 2822 1455 4413 3541 4113 M16969 GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. 19/23 Gene Ontology BP GO:0031998 0.68618940391 0.691390059851284 4095 3314 3595 0.1 2098 0.943539230643585 -0.916678382697101 -1 0.506376173985728 4095 2308 2560 2098 3047 4619 3595 3681 3882 2738 3831 4114 M10289 GO_NCRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). 21/26 Gene Ontology BP GO:0034661 0.68618940391 0.691390059851284 4125 3407.45454545455 3596 0.1 963 0.863418097189238 -0.844058869638759 -1 0.462471541076391 4122 3501 3596 2649 3689 3338 4199 3832 963 4074 3519 4115 M11175 GO_RENAL_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. 9/19 Gene Ontology BP GO:0072087 0.000823677385844398 0.00346060536608755 4440 3231.36363636364 3597 8.23982845199256e-05 165 1.37967255918949 -1.69041938081763 -1 11.5972255330277 4438 3597 4282 3757 1477 4239 4352 165 2211 3550 3477 4116 M12624 GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE.html A cascade of processes induced by the detection of DNA damage within a cell. 115/128 Gene Ontology BP GO:0042770 0.542986464164067 0.592328615210444 3780 3395.36363636364 3599 0.0687110278499813 2389 0.890680817443828 -0.888878707653373 -1 0.681927205952309 3779 2563 3697 2644 3437 4586 3599 3927 2587 4141 2389 4117 M16504 GO_AUTOPHAGOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. 47/52 Gene Ontology BP GO:1905037 0.0474347483455603 0.0713710336341759 4430 3004.90909090909 3600 0.00440813449647864 448 0.826719203120166 0.738350924003478 1 3.22986820795367 4430 1583 3698 1530 1440 4649 3600 4446 448 3821 3409 4118 M10537 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 21/23 Gene Ontology BP GO:1902254 0.68618940391 0.691390059851284 4545 3457 3603 0.1 1257 1.33880913004306 -1.07758448665646 -1 0.722975454163566 4542 2796 2744 2603 3858 4496 4539 3603 1257 3373 4216 4119 M12557 GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. 35/42 Gene Ontology BP GO:2000279 0.122604155173367 0.159395678687253 3005 3427.18181818182 3603 0.0118202244528802 1829 0.964181942398287 1.02680991134478 1 2.61836323158053 3004 4455 3603 4606 1829 3030 2207 2586 4444 3932 4003 4120 M12983 GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. 9/20 Gene Ontology BP GO:0014821 0.400737871453066 0.452580901910465 4115 3550.90909090909 3603 0.0499167024813839 2373 1.47256209669396 -1.57169234578927 -1 1.72277329946315 4111 3603 4398 3126 2487 3591 4069 4016 4409 2877 2373 4121 M16124 GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. 775/1069 Gene Ontology BP GO:0044403 0.6513215599 0.691390059851284 2150 3644.45454545455 3603 0.1 2150 0.960073763744775 1.03967646677893 1 0.515436737345689 2150 4615 4595 3887 4610 3360 2771 3496 2635 4367 3603 4122 M16770 GO_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METABOLIC_PROCESS.html Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. 750/1006 Gene Ontology BP GO:0006259 0.627259386486239 0.67296239919771 4650 3621 3607 0.0939739773115534 2262 0.81024408160235 -0.84059729919646 -1 0.465834034454483 2603 4618 4646 4493 3284 2262 3615 3607 3366 4649 2688 4123 M15194 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 26/29 Gene Ontology BP GO:1902253 0.68618940391 0.691390059851284 4590 3572.63636363636 3610 0.1 1648 1.33880913004306 -1.07758448665646 -1 0.722975454163566 4587 3122 2949 2212 4378 4570 4341 3338 1648 3610 4544 4124 M14870 GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 24/24 Gene Ontology BP GO:0090312 0.162676190090349 0.203531140761063 3615 3580 3611 0.0160108429416265 1343 0.91960137767411 -0.876493570048549 -1 2.16304933053568 3611 4508 3521 4468 3987 2599 4629 2612 4574 3528 1343 4125 M10114 GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 13/25 Gene Ontology BP GO:0090185 0.00173216260530238 0.00591253171939534 4420 3450.72727272727 3612 0.000157593447537655 239 1.27051690619801 -1.49137865997326 -1 9.66837545292301 4418 4550 2543 4376 3433 4412 4048 239 3612 3274 3053 4126 M13523 GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. 4/19 Gene Ontology BP GO:0006704 0.0847485422869595 0.116391666842155 3115 3485.09090909091 3613 0.00881654770968371 1711 2.00627097661241 2.00627097661241 1 6.39649185944058 3113 4609 4432 4335 1711 3252 3613 2037 4543 3026 3665 4127 M13456 GO_DNA_REPLICATION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INITIATION.html The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. 29/31 Gene Ontology BP GO:0006270 0.68618940391 0.691390059851284 3615 3725.45454545455 3614 0.1 2002 0.627454453858681 -0.627454453858681 -1 0.333168613200556 2002 4476 3909 4580 3613 3190 3094 3591 4363 4548 3614 4128 M12887 GO_RESPONSE_TO_INSECTICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSECTICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. 10/22 Gene Ontology BP GO:0017085 0.261944640419943 0.311004953272262 3955 3568 3620 0.027234666325539 2202 1.46911405399095 -1.46911405399095 -1 2.53707763391997 3955 4254 2420 4043 2202 3575 3205 3425 4552 3620 3997 4129 M10569 GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 41/50 Gene Ontology BP GO:0090329 0.065161121876685 0.0929759889887198 1780 2924.36363636364 3621 0.00610683044725934 790 0.689481389755307 0.749447754580065 1 2.42119737146837 1778 3746 3858 3804 4000 1142 790 1854 3621 4282 3293 4130 M11977 GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS.html The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. 13/17 Gene Ontology BP GO:0016973 0.0775327132557768 0.107785991867084 4510 3385.18181818182 3621 0.00730982190290674 1154 0.775981671645639 -0.585600857477817 -1 2.55598860692947 4510 3579 3621 2891 1629 4479 3208 4560 1154 3809 3797 4131 M15923 GO_CELLULAR_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. 14/14 Gene Ontology BP GO:0043482 0.525535378248412 0.575503910329457 2850 3541.54545454545 3621 0.065532966010026 2647 0.539150879149522 -0.539150879149522 -1 0.431647106349643 2846 3894 3653 3971 3621 3454 3445 2647 4121 4621 2684 4132 M13310 GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. 10/35 Gene Ontology BP GO:0002579 0.00264641989044819 0.00794951049080403 3185 3377 3622 0.000240873517129201 568 0.774359130799827 0.67897008683751 1 5.54817164862232 3182 4583 2421 3941 568 3724 3585 2572 4630 3622 4319 4133 M16896 GO_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. 14/14 Gene Ontology BP GO:0043476 0.588293644795144 0.635258837138966 2850 3553 3622 0.0775082169299381 2685 0.539150879149522 -0.539150879149522 -1 0.352563823144033 2847 3895 3654 3972 3622 3455 3446 2733 4122 4652 2685 4134 M16897 GO_FATTY_ACID_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_ELONGATION.html The elongation of a fatty acid chain by the sequential addition of two-carbon units. 11/13 Gene Ontology BP GO:0030497 0.0041924547577002 0.0111158763236233 4580 3476.36363636364 3623 0.000381860503328733 683 0.765680969480964 -0.531925947538817 -1 5.10471066619224 4578 3581 2769 3905 683 4268 4452 2786 4487 3108 3623 4135 M11912 GO_FOREBRAIN_GENERATION_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_GENERATION_OF_NEURONS.html The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. 70/114 Gene Ontology BP GO:0021872 0.0117174427156933 0.0233295939050582 2660 3010.63636363636 3624 0.00107093822383713 811 1.23781385168555 1.25413811092986 1 6.89638741938397 2658 3698 811 4275 3624 3131 1330 4436 3878 1362 3914 4136 M12831 GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL.html Any process that modulates the potential difference across a post-synaptic membrane. 35/76 Gene Ontology BP GO:0060078 0.0163657157508562 0.0303351805489082 3125 3313.54545454545 3625 0.00149897662529239 874 1.39506311020292 -1.29970585357645 -1 7.22991674178613 3122 4085 874 3705 3269 3625 3849 3990 3709 2671 3550 4137 M10944 GO_PEPTIDE_CROSS_LINKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CROSS_LINKING.html The formation of a covalent cross-link between or within protein chains. 47/103 Gene Ontology BP GO:0018149 1.2404507164732e-07 2.84325969642846e-06 3795 2580.27272727273 3630 1.12768253310448e-08 153 1.65125646252917 -1.89157162625972 -1 31.3006430428648 3795 2155 153 1601 438 4343 3949 3890 3630 441 3988 4138 M10516 GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. 52/70 Gene Ontology BP GO:0055024 0.0757705656952886 0.105699916776552 3710 3268.81818181818 3631 0.00713758130024576 1196 1.23130869411616 1.36549628668569 1 4.09776794682671 3708 2144 1196 2230 4620 4373 4408 3631 3347 2054 4246 4139 M13470 GO_PROTEIN_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MONOUBIQUITINATION.html Addition of a single ubiquitin group to a protein. 60/65 Gene Ontology BP GO:0006513 0.635999110615064 0.68139623801333 3990 3520.72727272727 3632 0.0877786713730183 2381 0.725900044515941 -0.81402141482356 -1 0.402808151523114 3990 3353 4010 3632 3880 2381 3516 4077 3124 4180 2585 4140 M14774 GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. 262/403 Gene Ontology BP GO:0002831 0.68618940391 0.691390059851284 3490 3746.63636363636 3635 0.1 2934 1.06606071121581 -1.01874205830715 -1 0.5735152719504 3490 3964 2934 4125 3924 4535 3635 3475 3336 3465 4330 4141 M14407 GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. 121/140 Gene Ontology BP GO:0000082 0.302948852333178 0.354710873152058 2045 3340.81818181818 3638 0.0322764019320226 1554 0.812988846818469 0.894498080678491 1 1.24049083513668 2044 4324 4069 4611 3320 1554 1698 3638 3414 4268 3809 4142 M15404 GO_ADULT_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. 14/29 Gene Ontology BP GO:0007512 0.68515032500782 0.691390059851284 3805 3534.54545454545 3638 0.0997294933257094 2400 1.12179830763062 0.700534988952162 1 0.604058258604916 3805 4547 2679 3954 2878 3638 2978 4223 2400 3370 4408 4143 M13098 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion. 11/17 Gene Ontology BP GO:2000778 0.381421294720178 0.433819064876804 3680 3229.45454545455 3639 0.0427267880165378 1221 0.780671014520214 -0.808051652474585 -1 0.957387039837787 4261 1221 3122 1911 2403 3680 4333 2986 4292 3676 3639 4144 M16377 GO_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that modulates the extent to which blood vessels can be pervaded by fluid. 28/38 Gene Ontology BP GO:0043114 0.0823338793222607 0.113519867262472 3780 3175 3639 0.00778063271786216 1505 1.18963180637532 -0.966871844895064 -1 3.83263260733183 3778 2733 1697 2811 3639 4497 4401 1505 3803 1722 4339 4145 M16803 GO_NEUROPEPTIDE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. 30/105 Gene Ontology BP GO:0007218 0.0377739641714783 0.0594594909641031 4305 3239.18181818182 3640 0.00349441585340211 1030 2.06558561012885 -2.13666434273589 -1 8.64594476954018 4305 3788 1030 4318 2049 4037 3278 3920 3640 2308 2958 4146 M10074 GO_FOREBRAIN_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. 48/71 Gene Ontology BP GO:0021884 0.0353899299334625 0.0563550116291584 3060 3098.54545454545 3641 0.0032702167705578 1017 1.35082526842344 1.31006580617921 1 5.75803104535002 3060 3731 1017 3641 4205 3798 1892 2933 3714 1789 4304 4147 M13413 GO_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G1_S_PHASE_TRANSITION.html The cell cycle process by which a cell in G1 phase commits to S phase. 121/140 Gene Ontology BP GO:0044843 0.302948852333178 0.354710873152058 2045 3340.27272727273 3642 0.0322764019320226 1553 0.812988846818469 0.894498080678491 1 1.24049083513668 2043 4323 4068 4610 3319 1553 1697 3642 3413 4267 3808 4148 M16191 GO_PEPTIDYL_LYSINE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_METHYLATION.html The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. 75/84 Gene Ontology BP GO:0018022 0.0989105440861669 0.132669576717479 4085 3335.54545454545 3643 0.0094235664585056 1738 1.09375212964627 -1.43500950784994 -1 3.26971713882378 4085 4023 3729 3837 1738 3643 2906 2223 3164 3784 3559 4149 M11643 GO_PEPTIDYL_CYSTEINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_CYSTEINE_MODIFICATION.html The modification of peptidyl-cysteine. 19/37 Gene Ontology BP GO:0018198 0.0529289844980253 0.0782333433511156 4130 3473.63636363636 3646 0.00493154513487981 1475 0.929363890663015 -0.753358032720202 -1 3.50552504029878 4129 2807 2451 3503 1475 3827 4639 4118 4475 3646 3140 4150 M10085 GO_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. 53/70 Gene Ontology BP GO:0002181 0.576706102877031 0.62434004110908 1830 3497.72727272727 3647 0.0751775487139376 1829 0.68657867754905 -0.823651352926129 -1 0.469560731288772 1829 4403 4123 4484 2855 2592 2305 3647 4344 4340 3553 4151 M11639 GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. 150/188 Gene Ontology BP GO:0034249 0.153715976811926 0.193832097589673 2280 3297.45454545455 3647 0.0150582238677244 1939 1.02905164247803 -1.03699186368507 -1 2.49636849710037 2279 3647 3824 4222 1939 3160 2534 4583 2131 3769 4184 4152 M15293 GO_NUCLEUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. 151/272 Gene Ontology BP GO:0006997 0.68618940391 0.691390059851284 3525 3420.18181818182 3647 0.1 742 0.82628714945445 -0.819543822590935 -1 0.442124591905977 3523 3304 4152 1943 3945 3647 3344 4198 742 4255 4569 4153 M10366 GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. 11/17 Gene Ontology BP GO:0031953 0.064045995540182 0.0917506210740353 3965 2555.09090909091 3649 0.00599910979716309 561 1.53970282683961 -1.28147057594466 -1 5.45033246076842 3964 1218 1148 561 3822 3748 3649 4301 607 1228 3860 4154 M11327 GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. 138/198 Gene Ontology BP GO:0098780 0.409770462078005 0.461214794399844 4515 3522 3649 0.046800684491218 1803 1.145624127734 -1.17668324152892 -1 1.30577070940215 4511 3649 2298 3907 4196 1803 3366 4246 3676 3522 3568 4155 M11808 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. 24/26 Gene Ontology BP GO:1902116 0.0703423353153663 0.0994539307877238 2915 3283.54545454545 3650 0.00660887045282301 847 0.728139835538263 -0.728139835538263 -1 2.4847291288482 2912 4154 3650 4425 3949 1658 2104 3318 4613 4489 847 4156 M13888 GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION.html The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential. 138/198 Gene Ontology BP GO:0098779 0.409770462078005 0.461214794399844 4515 3530 3650 0.046800684491218 1804 1.145624127734 -1.17668324152892 -1 1.30577070940215 4512 3650 2299 3908 4197 1804 3367 4324 3677 3523 3569 4157 M16150 GO_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION.html Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. 74/127 Gene Ontology BP GO:0061337 0.00172363218762232 0.0058971033595637 3540 3376.18181818182 3650 0.000156816734852827 552 1.20977010005109 -1.38037167959522 -1 9.21028824937978 3536 4015 552 4511 3831 2591 4024 3095 4200 3133 3650 4158 M15648 GO_MACROMITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMITOPHAGY.html Degradation of a mitochondrion by macroautophagy. 138/198 Gene Ontology BP GO:0000423 0.409770462078005 0.461214794399844 4515 3527.90909090909 3651 0.046800684491218 1805 1.145624127734 -1.17668324152892 -1 1.30577070940215 4513 3651 2300 3909 4198 1805 3368 4291 3678 3524 3570 4159 M16489 GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. 19/25 Gene Ontology BP GO:0072525 0.00961982013349911 0.0200443782909052 2180 3165.90909090909 3651 0.000878376683255397 624 0.91750381906959 0.841487109431435 1 5.31581208693056 2177 4190 3119 3978 3737 4103 3638 624 4514 3651 1094 4160 M16965 GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. 28/42 Gene Ontology BP GO:0048025 0.0482346818974021 0.0723520228461031 3145 3389.27272727273 3652 0.00448416951656064 1449 0.734824497047448 0.540102844237844 1 2.85476931040286 3144 4141 3860 3643 1449 3750 3197 3652 1993 3988 4465 4161 M10239 GO_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of mRNA metabolic process. 146/183 Gene Ontology BP GO:1903311 0.336014424738001 0.387959086428268 1100 3169.18181818182 3653 0.036542406322754 1100 0.800664103271644 0.771228806658833 1 1.11500635870703 1100 3653 4141 3884 2843 2362 1772 3823 3672 4329 3282 4162 M10937 GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that activates or increases the activity of a transporter. 89/118 Gene Ontology BP GO:0032411 0.169456423096595 0.210767371469782 2900 3303.09090909091 3653 0.0167378734357986 1597 1.05925597829283 1.02376691934635 1 2.43821067919282 2898 3327 1597 3933 1994 4566 3653 4351 3922 2072 4021 4163 M11065 GO_PRIMITIVE_STREAK_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMITIVE_STREAK_FORMATION.html The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. 10/19 Gene Ontology BP GO:0090009 0.258673323168193 0.307513278666735 3655 2726.90909090909 3653 0.0268434871439451 342 1.56616837357908 -1.54208946968681 -1 2.73164556853698 3653 1231 1555 1162 4209 4083 3996 4335 342 1646 3784 4164 M11133 GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 20/125 Gene Ontology BP GO:0048385 0.127152508347053 0.164298978433445 4165 3423.90909090909 3653 0.0122870207474962 1845 1.87527299407325 -2.16805813468314 -1 5.01826272243234 4163 3855 2908 3653 1845 2665 1866 4541 4230 3319 4618 4165 M12241 GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS.html The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. 236/275 Gene Ontology BP GO:0090305 0.68618940391 0.691390059851284 3595 3608.63636363636 3654 0.1 2255 0.902470622946258 -0.868562831459311 -1 0.483871473074624 3593 4640 4178 4485 2957 2405 3654 3885 2255 4387 3256 4166 M14993 GO_MEIOTIC_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE_PROCESS.html A process that is part of the meiotic cell cycle. 135/298 Gene Ontology BP GO:1903046 0.68618940391 0.691390059851284 3120 3628.18181818182 3654 0.1 3019 0.975377576743131 -1.19105061573897 -1 0.523822892943311 3119 3654 3926 3420 4381 3019 3742 3900 3395 4219 3135 4167 M12991 GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. 34/68 Gene Ontology BP GO:0001914 0.58998498929836 0.636937390998902 3765 3528.36363636364 3656 0.07785338186156 2729 0.896632784944565 -0.687432425654149 -1 0.589886590033852 3763 4101 3075 3656 2729 3034 3693 3040 4606 3347 3768 4168 M16062 GO_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_NUCLEUS.html A process in which a protein is transported to, or maintained in, a location within the nucleus. 186/234 Gene Ontology BP GO:0034504 0.0614189383435545 0.0886696618406947 1855 3062.36363636364 3656 0.00574579785792741 1377 0.908236405467249 0.986662851939189 1 3.25671930305928 1854 4296 3656 4627 3901 2380 1714 1377 3985 4059 1837 4169 M11186 GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. 12/23 Gene Ontology BP GO:0031645 0.440209815362859 0.490127456186786 3790 3509.27272727273 3657 0.0513779676316848 2348 2.38859042891176 -2.38859042891176 -1 2.51841771423409 3787 4239 2348 3988 2502 4390 3657 3071 4123 3189 3308 4170 M11466 GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING.html Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. 20/21 Gene Ontology BP GO:0000469 0.206639537313774 0.25038500999397 3410 3512.18181818182 3658 0.0208235508513379 1730 0.434428431155706 -0.475707803961843 -1 0.882577069632637 3409 1730 3998 3610 2097 4177 3658 3391 3776 4478 4310 4171 M15681 GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. 122/181 Gene Ontology BP GO:0007156 7.3887040731042e-07 1.34295468953726e-05 3465 3095.72727272727 3658 6.71700595872999e-08 197 1.52304901488227 1.3777081865919 1 25.358615223654 3465 3658 197 4305 4284 4431 3497 1252 3715 1268 3981 4172 M16243 GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that activates or increases the rate of ATP hydrolysis by an ATPase. 63/76 Gene Ontology BP GO:0032781 0.114252784671088 0.149878265315639 3660 3268.45454545455 3658 0.0109688242636376 929 0.904118968627041 -0.802468192048308 -1 2.53724049540272 3658 4365 3648 4618 2013 929 2358 3826 4549 4118 1871 4173 M13689 GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex assembly. 418/505 Gene Ontology BP GO:0043254 0.352412958935172 0.404883332821075 4585 3322.63636363636 3659 0.0387302267358185 2137 0.998869097319902 -0.973874339924386 -1 1.33033741840558 4585 3282 3659 2450 2355 3796 3990 3835 2688 3772 2137 4174 M13782 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. 19/24 Gene Ontology BP GO:1901018 0.157036634229686 0.197484178127224 4290 3505.54545454545 3659 0.0154101906164175 1953 0.954715785279159 -0.821642691258984 -1 2.28880648702099 4288 3837 2787 4323 1953 3028 3659 3672 3639 3236 4139 4175 M14055 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 27/31 Gene Ontology BP GO:2001267 0.00658190334191574 0.0148667942960844 4035 3464.81818181818 3659 0.000600152525954252 805 0.86741703930937 -0.773781889049523 -1 5.40990680791137 4033 4131 3390 4417 805 3409 4356 2898 4322 3659 2693 4176 M15496 GO_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION.html The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. 42/98 Gene Ontology BP GO:0001708 0.0254559672297869 0.0432760743588596 4085 2998.18181818182 3659 0.00234139792063772 420 1.2423594578108 -1.18379203724904 -1 5.78195851238936 4084 3065 1175 2180 4578 3964 3922 3659 3859 2074 420 4177 M13224 GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. 47/63 Gene Ontology BP GO:1903312 0.215213367471298 0.259830772922665 1955 3176.18181818182 3660 0.0217903036952491 1468 0.715513420102634 0.587223306946413 1 1.4211812849217 1954 4390 4034 3660 2345 2796 1468 4461 1713 4015 4102 4178 M16373 GO_TRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_PROCESSING.html The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. 112/118 Gene Ontology BP GO:0008033 0.301946808588046 0.353715634531766 3295 3652.36363636364 3661 0.0321500164856172 2274 0.803349026826767 -0.736449135650334 -1 1.22900711669068 3295 4335 4176 4479 2274 2851 3661 4649 2875 4399 3182 4179 M14409 GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of a different species. 775/1069 Gene Ontology BP GO:0044419 0.6513215599 0.691390059851284 2150 3649.45454545455 3663 0.1 2149 0.960073763744775 1.03967646677893 1 0.515436737345689 2149 4614 4492 3886 4609 3359 2770 3663 2634 4366 3602 4180 M14502 GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. 27/30 Gene Ontology BP GO:0098927 0.0460112505350829 0.0695776238998183 4620 3059.45454545455 3663 0.00427297209421934 524 0.799467247994882 -0.649644716782862 -1 3.15325732036279 4620 2240 3663 1065 1431 4010 4209 3626 524 3960 4306 4181 M16059 GO_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 715/1000 Gene Ontology BP GO:0030162 0.378231972057604 0.431139972068601 3825 3071.18181818182 3664 0.0464074737653318 494 1.06734630477838 -0.960518874720728 -1 1.32268851413086 3822 590 4591 494 2450 3664 4212 4520 2863 2419 4158 4182 M16331 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. 508/624 Gene Ontology BP GO:0045786 0.6513215599 0.691390059851284 3665 3476.45454545455 3664 0.1 1367 1.00517517913931 -0.966403565376328 -1 0.540151328879981 3664 3278 4614 2425 4452 3419 2828 4233 1367 3990 3971 4183 M16636 GO_ESTROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 18/50 Gene Ontology BP GO:0008210 0.00611383886908756 0.0140274616656136 4070 3388.90909090909 3664 0.000557354157653401 786 1.04196627755626 -0.96221749467304 -1 6.59059060601667 4070 4527 3313 4375 786 1615 3664 3357 4412 4006 3153 4184 M10833 GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. 24/34 Gene Ontology BP GO:0031290 0.00253389123672154 0.00770097708978793 2790 3121.18181818182 3668 0.000230619491643655 562 1.52978740890626 1.30229943744253 1 11.0432576756265 2788 3807 1427 4189 562 4629 3668 4507 2893 1351 4512 4185 M12918 GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. 80/90 Gene Ontology BP GO:0006368 0.0537683264231491 0.0793731036950866 3375 3556.36363636364 3669 0.00501174832811587 1480 0.608103848415315 -0.653427378457068 -1 2.27699893293803 3373 4017 4174 4107 1480 2956 3485 4022 3311 4526 3669 4186 M13823 GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. 184/225 Gene Ontology BP GO:0006352 0.461703884189387 0.511015264779547 3670 3306 3670 0.0547484764945328 735 0.977339817589265 -1.0019305714945 -1 0.963597722834835 3670 4298 4104 4209 3446 1904 2940 4565 735 4098 2397 4187 M11247 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. 3/14 Gene Ontology BP GO:0002839 0.0287646609428701 0.047681498883924 3550 3575.72727272727 3671 0.00291439212349966 1289 0.607942761840675 0.607942761840675 1 2.73641913199691 3550 4271 4288 4347 1289 2908 2891 3147 4505 4466 3671 4188 M11196 GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. 45/50 Gene Ontology BP GO:0046825 0.0180705746439645 0.0328104004827544 3145 3284.81818181818 3672 0.00165643037357378 1087 0.781975428142491 0.778233597568338 1 3.95682917165774 3145 3388 3735 3672 1087 2169 1881 4596 4264 4122 4074 4189 M11527 GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. 8/16 Gene Ontology BP GO:2000400 0.333185374355151 0.385362054902938 4255 3383 3672 0.0397141893728095 1963 1.40322862373189 -1.45163393814007 -1 1.97615782731101 4254 3601 4308 2551 3672 4604 2178 3918 4148 2016 1963 4190 M13866 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. 3/14 Gene Ontology BP GO:0002836 0.0287646609428701 0.047681498883924 3555 3599.27272727273 3672 0.00291439212349966 1290 0.607942761840675 0.607942761840675 1 2.73641913199691 3551 4272 4456 4348 1290 2909 2892 3134 4506 4562 3672 4191 M14393 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 53/56 Gene Ontology BP GO:0032206 0.167451812813974 0.208720408524891 3675 3104.45454545455 3672 0.0165223630706609 390 1.07062972334259 1.2302287356406 1 2.48002000443033 3190 4370 3847 3673 2525 3672 2404 1892 390 4103 4083 4192 M15036 GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. 8/16 Gene Ontology BP GO:0033089 0.333185374355151 0.385362054902938 4255 3404.90909090909 3673 0.0397141893728095 1964 1.40322862373189 -1.45163393814007 -1 1.97615782731101 4255 3602 4532 2552 3673 4605 2179 3921 4149 2022 1964 4193 M11329 GO_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. 983/1254 Gene Ontology BP GO:0051338 0.312955169379637 0.365048985490963 3720 3055 3674 0.0368398456982964 1289 1.09584649447835 -1.03235672903753 -1 1.62905062395137 3720 1289 4293 1537 2919 4581 3674 3748 2473 1381 3990 4194 M13856 GO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING.html The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. 202/235 Gene Ontology BP GO:0006457 0.452236777438618 0.50173050200808 1725 3257.90909090909 3675 0.0532491244125789 1724 0.837268417686256 -0.66156056044876 -1 0.846763408368733 1724 3973 4143 3675 4112 1881 2145 3780 3106 4374 2924 4195 M10803 GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. 126/152 Gene Ontology BP GO:0034250 0.68618940391 0.691390059851284 2490 3736.18181818182 3677 0.1 2488 0.890489815498418 0.969938759779181 1 0.477306252011512 2488 4310 3674 4551 4648 3677 3257 4422 2956 3407 3708 4196 M12901 GO_G1_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage. 88/99 Gene Ontology BP GO:0044783 0.211643911488687 0.255986254264846 3355 3368.81818181818 3677 0.021386664333292 2108 1.01998611628456 -1.02786055765553 -1 2.05305084571498 3352 3677 3399 3749 2108 3729 4600 3687 2130 4021 2605 4197 M11766 GO_SPERM_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MOTILITY.html Any process involved in the controlled movement of a sperm cell. 65/121 Gene Ontology BP GO:0030317 0.116795682724098 0.15265458194248 3685 3272.63636363636 3681 0.011227290520058 1604 1.27928490698839 -1.45422919443406 -1 3.55963349956667 3681 3712 1604 3744 4568 4148 3262 1703 3380 2496 3701 4198 M15803 GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. 9/33 Gene Ontology BP GO:0002825 0.526413544725554 0.576058848449671 2700 3404.63636363636 3681 0.0720171987770744 2210 1.067924969178 0.928620578078727 1 0.863915729759498 2700 4255 4574 4024 4266 2210 2269 2895 3681 2888 3689 4199 M11417 GO_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELINATION.html Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 46/53 Gene Ontology BP GO:0031641 0.157685996322863 0.198140140667103 2905 3574.36363636364 3682 0.0154791658213917 1955 1.10597556499344 -1.2070953964812 -1 2.64767577315808 2903 4382 2689 4420 1955 3682 3022 3589 4396 3991 4289 4200 M14915 GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. 108/123 Gene Ontology BP GO:1904029 0.0476987794327294 0.0716398224064126 2780 3421 3682 0.0044332246724077 1445 0.947961427315795 -0.963601716788937 -1 3.69981614649129 2778 4329 3682 4621 1445 2878 2337 3354 4307 3862 4038 4201 M11714 GO_PROTEIN_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLATION.html The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 113/135 Gene Ontology BP GO:0006479 0.161287659194746 0.202065556874839 4180 3338.81818181818 3683 0.0158626141399883 1567 0.961416213423309 -1.13443140252972 -1 2.27220593824506 4178 3666 3965 3817 1968 4511 3683 2389 2927 4056 1567 4202 M10437 GO_MULTI_ORGANISM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_TRANSPORT.html The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. 76/115 Gene Ontology BP GO:0044766 0.284330497511038 0.334595297146904 3685 3466.45454545455 3684 0.0299546315943676 1359 0.876666424222905 -0.89362886070703 -1 1.41448273632947 3684 3688 3999 3594 3307 4417 4540 2203 1359 4166 3174 4203 M16145 GO_PROTEIN_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALKYLATION.html The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 113/135 Gene Ontology BP GO:0008213 0.161287659194746 0.202065556874839 4180 3308.81818181818 3684 0.0158626141399883 1568 0.961416213423309 -1.13443140252972 -1 2.27220593824506 4179 3667 3966 3818 1969 4512 3684 2048 2928 4058 1568 4204 M13896 GO_MULTI_ORGANISM_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_LOCALIZATION.html A localization which involves another organism. 76/115 Gene Ontology BP GO:1902579 0.481023900165115 0.530883350917524 3685 3501.36363636364 3685 0.057884161032292 1360 0.876666424222905 -0.89362886070703 -1 0.813590947344901 3685 3689 4000 3595 3308 4418 4541 2576 1360 4168 3175 4205 M10934 GO_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLATION.html The modification of histones by addition of methyl groups. 81/94 Gene Ontology BP GO:0016571 0.316345339352119 0.368599199746718 2875 3452.72727272727 3686 0.0339821269451084 1730 0.925086623256655 -1.10660144489082 -1 1.36024879233221 2871 3686 3971 3874 3456 2610 1730 3526 3772 4129 4355 4206 M12316 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. 127/212 Gene Ontology BP GO:1902107 0.147424570751957 0.186556031468277 3840 3203.72727272727 3690 0.0143948072586891 1378 1.2109086728725 -1.22396900108198 -1 3.00821087327389 3838 3990 1378 3518 1982 4195 3824 3239 3690 1428 4159 4207 M14903 GO_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_SLEEP.html Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. 11/36 Gene Ontology BP GO:0030431 0.221690075371497 0.267164962627188 2480 3487.18181818182 3690 0.022526979967232 2062 1.04296390519878 -0.401607071018994 -1 2.03334910606715 2478 4240 2437 4508 4475 3870 2381 2062 4539 3679 3690 4208 M14806 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. 79/110 Gene Ontology BP GO:0008543 0.68618940391 0.691390059851284 4085 3753.54545454545 3692 0.1 2950 1.03372662454632 -1.13779437988485 -1 0.555796897977427 4082 4011 3317 4436 2969 4626 3342 4259 2950 3692 3605 4209 M14831 GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of chromosome organization. 165/184 Gene Ontology BP GO:2001252 0.418584907094268 0.47011237574454 2540 3340.81818181818 3692 0.0481036451322886 2466 1.08121550387783 1.05267999030656 1 1.20108271814232 2537 3982 3923 3890 3721 2926 2520 2466 3027 4065 3692 4210 M11124 GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that activates or increases the frequency, rate or extent of viral genome replication. 37/50 Gene Ontology BP GO:0045070 0.68618940391 0.691390059851284 3000 3600.54545454545 3696 0.1 2999 0.683188788316321 0.781482882174202 1 0.36370981237372 2999 3765 3925 3674 3075 3966 3774 3343 3696 4144 3245 4211 M10211 GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. 12/14 Gene Ontology BP GO:0008608 0.68618940391 0.691390059851284 3855 3387.09090909091 3697 0.1 204 1.28200719035278 1.49087622784141 1 0.691849230617804 3851 4245 3237 3292 3468 3697 3453 3947 204 3753 4111 4212 M14189 GO_DRUG_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORT.html The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/52 Gene Ontology BP GO:0015893 0.0452948033370389 0.0685610669899941 3700 3360.72727272727 3697 0.00420501413337194 1226 1.050671752397 -1.04359033865616 -1 4.17036945719496 3699 3426 2198 3900 4180 4224 3697 1226 4023 3581 2814 4213 M15338 GO_GOLGI_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LOCALIZATION.html Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. 18/19 Gene Ontology BP GO:0051645 0.0211045436416984 0.0370144898472759 3700 2981.18181818182 3698 0.00193725094825943 440 0.706719563317903 0.651492750970932 1 3.44849036794408 3698 1748 3773 1118 1152 4519 4000 3645 440 4608 4092 4214 M10362 GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. 180/198 Gene Ontology BP GO:0032434 0.68618940391 0.691390059851284 2965 3574.54545454545 3699 0.1 1566 0.929234923364054 -0.877896976885441 -1 0.498537725713051 3226 2965 4080 2962 4569 3699 3498 4353 1566 4206 4196 4215 M11376 GO_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_CONTRACTION.html Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. 210/333 Gene Ontology BP GO:0008016 3.72580878893198e-09 1.34389056549616e-07 2780 3084 3700 3.38709890476529e-10 94 1.2632302862146 -1.41715035917985 -1 29.6673692512038 2776 1979 94 3896 4225 4430 3700 4609 3533 430 4252 4216 M14852 GO_MISMATCH_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR.html A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. 30/34 Gene Ontology BP GO:0006298 0.733521917927299 0.738441688471597 2325 3612.09090909091 3701 0.1132781533638 2322 0.564586843232831 -0.582686209233978 -1 0.243525529593894 2322 4459 3715 4446 3701 2419 3400 3188 4576 4587 2920 4217 M15695 GO_REGULATION_OF_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_COHESION.html Any process that modulates the frequency, rate or extent of sister chromatid cohesion. 20/21 Gene Ontology BP GO:0007063 0.0105112329762141 0.0214700469878507 4325 2938.63636363636 3701 0.000960162946282955 32 1.42190449396559 -1.34986150861946 -1 8.09899211023404 4324 1068 3288 1343 920 4639 4353 4197 32 3701 4460 4218 M13938 GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. 18/18 Gene Ontology BP GO:0007004 0.0638788001142213 0.0915957032146292 3730 3527.36363636364 3703 0.00598296886128999 1541 0.739324146089594 -0.739324146089594 -1 2.61341631782534 3908 3532 3896 3161 1541 3726 3703 3665 3729 4564 3376 4219 M16380 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. 20/23 Gene Ontology BP GO:0016447 0.68618940391 0.691390059851284 4340 3635 3703 0.1 1871 0.787251810063953 -0.783646565257884 -1 0.420734077661596 4337 2804 3529 3288 3304 4360 4449 4102 1871 3703 4238 4220 M12573 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 266/314 Gene Ontology BP GO:0010948 0.68618940391 0.691390059851284 4500 3579.54545454545 3705 0.1 1075 1.04796708485701 -0.963582979478368 -1 0.563600359504305 4500 3633 4006 2460 3600 4494 3682 4058 1075 4162 3705 4221 M13379 GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 13/15 Gene Ontology BP GO:0009113 0.022177840323711 0.0385194068780244 3635 3200.72727272727 3705 0.00203678350874158 1161 0.669033463555864 -0.710107176922447 -1 3.22443991760837 3633 2373 3772 2678 1161 3705 4145 4028 1410 4542 3761 4222 M15048 GO_PROTEIN_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSMEMBRANE_TRANSPORT.html The directed movement of a protein across a membrane by means of some agent such as a transporter or pore. 68/79 Gene Ontology BP GO:0071806 0.141170802786078 0.1796192905014 2160 3172.18181818182 3705 0.0137397555730769 1692 0.607932423282704 -0.579823547883449 -1 1.53915637448311 2158 3705 4105 3880 4500 1731 1692 1808 4594 4370 2351 4223 M16839 GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-12 production. 64/124 Gene Ontology BP GO:0032655 0.68618940391 0.691390059851284 3875 3372 3706 0.1 2343 0.973636383966921 -0.899116356306024 -1 0.52286875729435 3874 3706 2343 3152 3486 2559 3729 3865 3873 2717 3788 4224 M14642 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 72/84 Gene Ontology BP GO:0010803 0.169894964496618 0.211030771436936 3910 3480.18181818182 3707 0.0167850828984847 1371 1.02027318816422 -1.09893219988155 -1 2.34619506301634 3907 4019 3148 3563 4024 4187 4570 2974 3707 2812 1371 4225 M14979 GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS.html The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. 21/26 Gene Ontology BP GO:0006607 0.569905220890926 0.618127970350927 2125 3495.81818181818 3707 0.0738365205045302 2123 0.845667357784796 1.00730961113662 1 0.593390667363118 2123 4521 3951 3851 2689 3519 3474 4361 2179 4079 3707 4226 M12018 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. 402/532 Gene Ontology BP GO:0000226 0.496160940040205 0.546035206718797 3700 3522.72727272727 3708 0.0604159815385443 1631 1.03763524747565 -1.130263417078 -1 0.92157863857138 3697 4285 3708 2536 4476 3499 4586 4255 1631 3802 2275 4227 M12014 GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. 21/25 Gene Ontology BP GO:0046621 0.232473504522966 0.27900418275609 3710 3825.27272727273 3709 0.0237659679657075 2149 0.513350981940387 -0.584866719132462 -1 0.962356984193055 3709 4523 3490 4474 2149 3480 3672 4285 4644 4496 3156 4228 M16616 GO_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_BACTERIUM.html Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. 160/539 Gene Ontology BP GO:0042742 2.75180447211081e-11 1.77835364010161e-09 4600 3118.54545454545 3709 2.50164042922294e-12 49 1.56514395433814 -1.57535399005652 -1 46.8117574658439 4599 2971 49 3898 3035 4220 4195 4097 3369 162 3709 4229 M11496 GO_XENOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XENOPHAGY.html The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. 103/157 Gene Ontology BP GO:0098792 0.189581134045996 0.232749608632195 3735 3484.81818181818 3711 0.018928030569573 1975 1.21991423115683 -1.15117167414974 -1 2.62993107830103 3734 4328 2152 3693 3902 2590 4475 1975 3711 3464 4309 4230 M13638 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS.html The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. 36/43 Gene Ontology BP GO:0002200 0.445364250618005 0.495286772974564 4050 3751.09090909091 3711 0.0521753761966846 2513 0.823494188246238 -0.80029344339256 -1 0.848463043792428 4048 4088 3691 4001 2513 4213 3620 4365 3327 3711 3685 4231 M12849 GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. 4/14 Gene Ontology BP GO:0072283 0.0040278956196913 0.0108522283256651 4430 3560.54545454545 3712 0.000403521507293481 702 0.696521015863651 -0.634863115794106 -1 4.66749101919334 4426 2928 4390 3712 702 2982 3294 4441 3193 4524 4574 4232 M12056 GO_PEPTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 554/740 Gene Ontology BP GO:0006518 0.6513215599 0.691390059851284 3715 3511 3713 0.1 1209 0.955154985997109 -0.856979017458302 -1 0.512741354466502 3713 4278 4340 3787 3525 2911 3727 3126 1209 4401 3604 4233 M15477 GO_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of organelle assembly. 168/202 Gene Ontology BP GO:1902115 0.68618940391 0.691390059851284 3715 3515.63636363636 3714 0.1 2010 0.8869959421499 -0.883651388508429 -1 0.475391685651992 3714 2010 4009 2200 3998 4596 4454 3585 2361 4088 3657 4234 M15163 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION.html The process in which immune receptor genes are diversified through somatic mutation. 11/14 Gene Ontology BP GO:0002566 0.000312654888711531 0.00175486513531334 1320 2753.09090909091 3718 2.84272118883635e-05 75 0.424155703046377 -0.424155703046377 -1 3.98564137071437 1318 4251 3718 4552 3782 1200 946 75 4446 4597 1399 4235 M12021 GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition. 80/93 Gene Ontology BP GO:1902749 0.407887912063676 0.459651841809708 2710 3420.90909090909 3720 0.0465246980113392 1798 1.00345021146269 0.864025368206022 1 1.14745675221132 2708 3684 3662 3871 4379 1798 1940 3764 4088 3720 4016 4236 M16244 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI.html The directed movement of a protein to a specific location in the Golgi apparatus. 18/19 Gene Ontology BP GO:0072600 0.68618940391 0.691390059851284 3790 3373.63636363636 3721 0.1 712 0.750253163814458 0.836759659623341 1 0.400459626818336 3790 2823 3696 2867 2893 4247 3721 4211 712 4005 4145 4237 M13468 GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION.html The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). 14/22 Gene Ontology BP GO:0042074 0.546258906292826 0.59539533637398 4410 2929.63636363636 3725 0.0693192361936376 166 1.3879145647566 -1.43972561707191 -1 1.057932090031 4407 1168 2089 1430 3968 3725 4512 4542 166 1634 4585 4238 M14004 GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. 87/125 Gene Ontology BP GO:0060333 0.311662636620029 0.364180373730034 3725 3702.45454545455 3725 0.0333824685465406 2205 0.976968011720231 -0.950425014957738 -1 1.45462874180255 4502 3678 2205 3725 2290 4329 4595 4386 3724 3174 4119 4239 M14807 GO_CARDIOLIPIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOLIPIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. 14/15 Gene Ontology BP GO:0032048 0.179130124444445 0.221144194491909 3390 3749.90909090909 3726 0.0177845613023193 1945 0.739871322567387 -0.331725618276993 -1 1.64703363853505 3386 4551 3456 4167 3726 4425 4641 1945 4537 3368 3047 4240 M11173 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. 18/22 Gene Ontology BP GO:2000010 0.0585662570700134 0.0851589981708664 3995 3081.54545454545 3730 0.00547145922495538 1157 1.0281217287251 1.20949066516592 1 3.74967755916114 3991 1750 2471 1157 3730 4423 3875 1358 4136 2641 4365 4241 M12598 GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 32/35 Gene Ontology BP GO:0033146 0.003528035653606 0.00988912644351128 4060 3366.18181818182 3730 0.000321246012000662 634 0.600622946591519 -0.700507095735145 -1 4.10627694662734 4058 3103 3730 3392 634 4437 4018 2454 4478 4222 2502 4242 M12155 GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. 478/568 Gene Ontology BP GO:0010608 0.68618940391 0.691390059851284 4620 3745.18181818182 3731 0.1 2180 0.876114994158876 -0.842985486101064 -1 0.469429163572549 4617 3623 4192 3889 3731 3636 4456 3010 2180 4369 3494 4243 M10265 GO_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXPORT_FROM_NUCLEUS.html The directed movement of a protein from the nucleus into the cytoplasm. 51/55 Gene Ontology BP GO:0006611 0.00958098309669069 0.0200270475881494 3420 3345.27272727273 3732 0.00087481494436529 220 0.650534176926417 -0.623923261133185 -1 3.76678258674637 3419 3732 3897 4279 4443 2366 2812 2862 4583 4185 220 4244 M13431 GO_METHIONINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 13/16 Gene Ontology BP GO:0009086 0.00155475534405904 0.0054846676390498 2655 3345.45454545455 3732 0.000141441380803048 466 0.404905078658261 0.404905078658261 1 3.11914262156125 2654 3575 3904 3848 466 2751 2858 3942 4525 4545 3732 4245 M14190 GO_POSITIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GROWTH.html Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. 289/393 Gene Ontology BP GO:0045927 0.0007463338704537 0.00322176520094511 3735 2554.72727272727 3732 6.7871561732901e-05 170 1.25615871021092 -1.2566045351833 -1 10.6914274535509 3732 654 520 170 4230 4289 3793 4600 1287 321 4506 4246 M16660 GO_NUCLEAR_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 220/255 Gene Ontology BP GO:0098813 0.68618940391 0.691390059851284 2490 3706.72727272727 3732 0.1 2487 0.82414204165063 -0.893848661775427 -1 0.440949119635214 2487 4644 4194 4624 3279 3601 4020 3732 2561 4400 3232 4247 M10847 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. 14/15 Gene Ontology BP GO:0043923 0.68618940391 0.691390059851284 3740 3383.09090909091 3736 0.1 1197 0.559537610694273 -0.539934278654199 -1 0.29595166507546 3736 1197 3641 1429 3798 3215 2730 4295 4286 4455 4432 4248 M12146 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. 62/127 Gene Ontology BP GO:0001910 0.56484237455664 0.613065446422217 4340 3686.63636363636 3736 0.0728506658529109 1880 1.01743849239897 -0.870857565721425 -1 0.728509315219744 4336 4036 1880 3993 3736 3532 4193 3639 4439 3170 3599 4249 M12226 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 61/71 Gene Ontology BP GO:1902041 0.0107027633054609 0.0217752329078747 4485 3469.36363636364 3736 0.000977744409725959 924 1.24734963656655 -1.20509851842949 -1 7.07729891870781 4481 4363 2527 4241 924 3679 4236 4213 3484 2279 3736 4250 M13846 GO_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T cell differentiation. 100/190 Gene Ontology BP GO:0045580 0.0339244163589344 0.0543561671205653 3815 3168.63636363636 3736 0.00313264698043997 1321 1.1390950759672 -1.10473148438956 -1 4.91491846257396 3812 4337 2059 4358 1321 3821 3828 2928 3736 2084 2571 4251 M12629 GO_TELOMERE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_LOCALIZATION.html Any process in which a telomere is transported to, and/or maintained in, a specific location. 7/12 Gene Ontology BP GO:0034397 0.836998017547888 0.840974255160942 3375 3912.54545454545 3737 0.165897757821142 3189 0.196912311275411 -0.103821376754804 -1 0.039976018602933 3371 4264 4379 4556 3189 3380 3482 3572 4592 4516 3737 4252 M16681 GO_SYNCYTIUM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNCYTIUM_FORMATION.html The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. 31/57 Gene Ontology BP GO:0006949 0.000622087695919636 0.00285179709272322 4380 2926.45454545455 3737 5.65694246857215e-05 132 1.13904053897636 -1.44601950987825 -1 9.89991886627588 4376 4105 1087 3737 2051 4217 4640 132 4404 2778 664 4253 M12180 GO_WATER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSPORT.html The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/21 Gene Ontology BP GO:0006833 0.683923252404982 0.691390059851284 3745 3582.54545454545 3739 0.0994110888137401 2022 1.37041496194894 -1.11459678042491 -1 0.740294760416422 3741 4243 2022 4312 2910 3739 3289 4142 4507 3095 3408 4254 M11730 GO_RRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_TRANSCRIPTION.html The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. 21/27 Gene Ontology BP GO:0009303 0.00531482496888279 0.0131766533742567 3760 2918.63636363636 3740 0.000484337115866099 643 1.22991123588944 -1.4497145999638 -1 7.8955601100221 3757 3828 2913 3983 746 3757 4344 2478 1916 3740 643 4255 M14095 GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. 15/21 Gene Ontology BP GO:1900273 0.165478380861386 0.206472542547722 4480 3610.09090909091 3741 0.0163106648975436 1888 2.96579655355389 -3.30819146700029 -1 6.93656658562863 4480 4560 2187 4257 3220 4100 3564 1888 4269 3445 3741 4256 M13726 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. 42/48 Gene Ontology BP GO:0008625 0.130377304598913 0.16776703492775 3760 3476.45454545455 3744 0.0126193223418299 1858 0.995772613334023 -0.715088677031978 -1 2.62881902398916 3758 3744 3391 4180 1858 4116 4403 3295 1877 3088 4531 4257 M13791 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. 42/66 Gene Ontology BP GO:0002639 0.0739402071932702 0.103596442056696 3510 3629.72727272727 3747 0.00695898925052249 1606 0.852757421294386 -0.930999646779447 -1 2.86013163171972 3509 3747 3321 4036 1606 4132 4491 3815 4365 3410 3495 4258 M14619 GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. 30/32 Gene Ontology BP GO:0000289 0.00590218369173484 0.0136699157380001 1615 3327.54545454545 3747 0.000538007078482862 775 0.574497292282371 0.621288552261338 1 3.6510212877902 1611 4458 4042 4453 775 2974 3098 3747 4159 4583 2703 4259 M10422 GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. 30/70 Gene Ontology BP GO:0002820 0.671977418847998 0.691390059851284 4095 3579.27272727273 3748 0.0963687340547068 2009 1.25022481721049 -1.55362341970907 -1 0.674433183619481 4093 3444 2009 3748 4333 4143 3148 3484 4232 2300 4438 4260 M14516 GO_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPOLYMERIZATION.html The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. 35/40 Gene Ontology BP GO:0051261 0.68618940391 0.691390059851284 4465 3584.45454545455 3748 0.1 2614 0.983294787794273 0.672379423024914 1 0.528161351847716 4464 3421 2937 2614 3854 3371 3781 4468 4098 2673 3748 4261 M15483 GO_CELL_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_RECOGNITION.html Cell recognition between cells. May involve the formation of specialized cell junctions. 60/135 Gene Ontology BP GO:0009988 0.429076635424124 0.480272692958491 3755 3274.72727272727 3751 0.0496781591398914 1946 1.2755176897518 1.25910029901557 1 1.37834557962781 3751 4034 2136 1946 2481 4397 4100 4216 2469 2209 4283 4262 M15339 GO_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G2_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. 41/46 Gene Ontology BP GO:0031572 0.155539622238532 0.195866268545572 4135 3417 3752 0.0152513619421354 1217 0.801703780523083 -0.857858155635454 -1 1.93006385600454 4131 3392 3752 3799 1948 4053 3645 3142 1217 4188 4320 4263 M14047 GO_ACTIVATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_IMMUNE_RESPONSE.html Any process that initiates an immune response. 389/757 Gene Ontology BP GO:0002253 0.00358386185520162 0.00998545461811565 3885 2679.90909090909 3753 0.000326337583325913 297 1.14184368715943 1.16432429498113 1 7.79961211424257 3881 622 640 297 4580 3753 3788 4651 2417 706 4144 4264 M16866 GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. 13/14 Gene Ontology BP GO:0046498 0.099351745296963 0.133079111773474 3890 3355.81818181818 3755 0.0094676687108599 1651 0.833464590095692 -0.92769189235378 -1 2.48524881589311 3889 4225 3664 4181 1743 3755 4260 1651 2963 3816 2767 4265 M11230 GO_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_VIRUS.html Reactions triggered in response to the presence of a virus that act to protect the cell or organism. 175/318 Gene Ontology BP GO:0051607 0.637332389248951 0.68237516426903 4405 3591.27272727273 3757 0.0880829350905549 1961 1.15836515920213 -1.00284993255596 -1 0.646669996945181 4401 3642 1961 4132 3265 4244 4431 4218 3247 2206 3757 4266 M10904 GO_NEGATIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPAIR.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. 15/17 Gene Ontology BP GO:0045738 0.431601217008652 0.481707954603324 3370 3790.09090909091 3760 0.0500609522564592 2490 0.42024668378198 -0.35557695171939 -1 0.445113885712093 3370 4548 3754 4424 2490 3760 2634 3570 4628 4457 4056 4267 M14652 GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. 12/12 Gene Ontology BP GO:0051292 0.0176806916586504 0.032224151307364 4560 3094 3760 0.0016204004800431 439 0.770986749770215 -0.668527582391234 -1 3.92171585605057 4559 1206 3580 1877 1079 4223 4524 4283 439 3760 4504 4268 M12685 GO_PROTEIN_K11_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K11_LINKED_UBIQUITINATION.html A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. 30/35 Gene Ontology BP GO:0070979 0.312654337090289 0.364890855669922 3765 3538.90909090909 3761 0.0335091537031949 2292 0.478795085519091 -0.468334800312004 -1 0.706065608612198 3761 3786 4062 4091 2292 2830 3494 2593 4359 4518 3142 4269 M10406 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 15/20 Gene Ontology BP GO:0038084 0.56261508616775 0.611058631692172 4640 3745.18181818182 3762 0.0724202595981752 2208 0.926210903159946 -0.627514881947857 -1 0.666741396984404 4639 4218 2208 3605 3762 3990 3725 2704 4415 3432 4499 4270 M11000 GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION.html The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. 25/26 Gene Ontology BP GO:0006271 0.68618940391 0.691390059851284 2255 3507.09090909091 3762 0.1 2254 0.683229859553315 -0.687553000775944 -1 0.363732318515428 2254 3800 3762 3930 4279 2732 3108 4262 2929 4136 3386 4271 M13637 GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. 107/218 Gene Ontology BP GO:0002706 0.596785440580783 0.643234342140927 3250 3597.27272727273 3763 0.0792543938905174 2476 1.00007820594919 1.05661338318277 1 0.644564044354617 3248 4327 2476 4363 4069 3788 3401 2756 4349 3030 3763 4272 M14671 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition. 119/135 Gene Ontology BP GO:1902807 0.68618940391 0.691390059851284 4595 3477.18181818182 3763 0.1 952 1.17169469362916 -1.0549952061518 -1 0.631400389405112 4595 3991 3089 2388 3162 4600 3763 4072 952 3531 4106 4273 M10377 GO_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. 61/78 Gene Ontology BP GO:0031060 0.68618940391 0.691390059851284 4175 3574.18181818182 3765 0.1 1942 1.15571669018921 -1.44102621484389 -1 0.622644792156168 4174 3714 3780 3859 3765 3782 3042 3722 1942 3793 3743 4274 M15211 GO_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRITY_CHECKPOINT.html A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. 173/197 Gene Ontology BP GO:0031570 0.635163612704894 0.680789109317021 3240 3495.54545454545 3765 0.0875885207405908 1599 0.913158896973577 -0.937145548114553 -1 0.510678977366157 3239 3644 3950 3765 4171 3165 4342 3778 1599 4214 2584 4275 M16605 GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY.html Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex. 14/15 Gene Ontology BP GO:0051488 0.794236301686297 0.798526687931361 3765 3825 3765 0.133878183774711 2734 0.502914154029585 -0.461432163121993 -1 0.157344426246278 3765 3905 3673 3805 4572 3437 2734 3263 4515 4644 3762 4276 M11737 GO_SINGLE_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves only one organism. 109/124 Gene Ontology BP GO:1902591 0.000187482670610503 0.00119660071972489 4345 2917.90909090909 3766 1.70453317888048e-05 36 1.02162920314208 -0.860565356847691 -1 10.1957580337672 4342 36 2990 1358 188 3997 4438 4202 2275 3766 4505 4277 M16233 GO_REGULATION_OF_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. 29/51 Gene Ontology BP GO:0060306 0.00914037771780916 0.0192705833805918 1600 2954.36363636364 3766 0.000834415979116505 777 1.39429692449926 -1.57147182807901 -1 8.1652911667069 1597 4110 777 3925 4133 4209 2050 4039 3766 1823 2069 4278 M12648 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation. 18/54 Gene Ontology BP GO:0002577 0.00769044324734979 0.0167919438901542 3240 3280.90909090909 3767 0.000701587154164223 836 1.36428741761289 1.18215636920154 1 8.26822401197679 3238 4182 1417 3914 836 4628 3009 3767 3928 2648 4523 4279 M14554 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. 170/194 Gene Ontology BP GO:1901988 0.68618940391 0.691390059851284 3880 3496.18181818182 3767 0.1 824 1.15570299153757 -1.03008125996018 -1 0.622637285593969 3876 3978 3470 2865 3656 3916 4480 4471 824 3767 3155 4280 M11005 GO_APICAL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_ASSEMBLY.html The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. 55/65 Gene Ontology BP GO:0043297 0.355317282644146 0.408018587399608 4480 3638.45454545455 3768 0.0391229498268039 1647 0.861775036634335 -0.916223961139935 -1 1.1364156564081 4477 3717 3487 3768 4083 1647 4113 4184 3364 3823 3360 4281 M11658 GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. 24/35 Gene Ontology BP GO:0046471 0.403679148482474 0.455239718344389 4435 3371.27272727273 3770 0.0459105567831858 1806 1.22047450878778 -1.34238050498545 -1 1.41541163610537 4432 3810 2736 1806 2444 4411 4552 3986 2881 2256 3770 4282 M10946 GO_PEPTIDYL_SERINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_SERINE_MODIFICATION.html The modification of peptidyl-serine. 177/216 Gene Ontology BP GO:0018209 0.68618940391 0.691390059851284 3915 3284.63636363636 3771 0.1 718 0.886156759682656 -0.822408995611157 -1 0.474931831970699 3913 718 3335 1925 4533 4196 3084 4265 2511 3771 3880 4283 M14934 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. 42/45 Gene Ontology BP GO:0006383 0.68618940391 0.691390059851284 4365 3868.45454545455 3771 0.1 2759 0.655219353662245 -0.656684736756674 -1 0.348383172469548 4365 3751 4106 4271 3698 2759 4082 3771 3725 4295 3730 4284 M15034 GO_RNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYADENYLATION.html The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. 32/35 Gene Ontology BP GO:0043631 0.10238342536014 0.136501455071842 3010 3629.45454545455 3774 0.00977124617953363 1756 0.740807687050208 0.706891047014568 1 2.17984642469858 3007 3774 3961 4186 1756 4487 4286 3717 3059 4224 3467 4285 M10353 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. 19/23 Gene Ontology BP GO:0033962 0.68618940391 0.691390059851284 3935 3750.90909090909 3775 0.1 2811 1.09306711522541 -1.09306711522541 -1 0.588314192074493 3934 2811 3474 3982 4156 3550 3467 3775 3571 4022 4518 4286 M11174 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. 820/988 Gene Ontology BP GO:0070647 0.6513215599 0.691390059851284 4265 3763.72727272727 3775 0.1 2678 0.806090241578374 -0.770735712034839 -1 0.431057127081505 4264 3619 4281 3430 2986 3775 4584 4320 2678 4427 3037 4287 M11898 GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. 25/28 Gene Ontology BP GO:1903205 0.68618940391 0.691390059851284 3050 3748.45454545455 3775 0.1 3046 0.893300904653032 1.09324301742582 1 0.47884666753096 3046 4135 3097 3795 4447 3746 4014 3347 4270 3561 3775 4288 M15853 GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION.html A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. 389/501 Gene Ontology BP GO:0023014 0.195534793276122 0.238861484146441 4030 2869.90909090909 3775 0.0195854419499875 528 1.04691263063435 -0.995300094746992 -1 2.21516320778255 4030 620 1459 528 4079 4314 3775 4415 2414 1933 4002 4289 M13140 GO_CHEMOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of chemicals. 16/29 Gene Ontology BP GO:0007635 0.68618940391 0.691390059851284 4510 3594.09090909091 3776 0.1 2382 1.16930583245684 -1.35437432411137 -1 0.630091345607046 4508 3542 2382 3547 3170 3825 3904 4069 4367 2445 3776 4290 M16319 GO_KINETOCHORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 12/12 Gene Ontology BP GO:0051383 0.036058668678953 0.0572631349362349 4185 3697.63636363636 3776 0.00333305534741528 1333 0.703227623819831 0.703227623819831 1 2.97577592908818 4183 3251 3623 3776 1333 3728 3974 3724 4065 4634 4383 4291 M11125 GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. 63/118 Gene Ontology BP GO:0045824 0.55895899098534 0.60753005957832 4280 3553.45454545455 3779 0.0717180483864955 1877 1.08336473753945 1.32519298200029 1 0.790995104439661 4569 3030 1877 3069 3417 4282 4278 3779 4279 2395 4113 4292 M12024 GO_SOMATIC_CELL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_CELL_DNA_RECOMBINATION.html Recombination occurring within or between DNA molecules in somatic cells. 30/36 Gene Ontology BP GO:0016444 0.68618940391 0.691390059851284 4190 3865.45454545455 3779 0.1 3270 0.821251296820532 0.851335082070651 1 0.43936505454367 4187 4108 3625 4169 4467 3390 3270 3365 3519 3779 4641 4293 M14545 GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. 17/21 Gene Ontology BP GO:2000773 0.737832093230644 0.742459500389747 4295 3687.36363636364 3779 0.114591690838643 2826 0.726720100200042 -0.56790211522287 -1 0.310666001960519 4295 2826 3068 2959 2963 3779 3699 4304 4571 3969 4128 4294 M14068 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS.html The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. 30/36 Gene Ontology BP GO:0002562 0.68618940391 0.691390059851284 4190 3861.81818181818 3780 0.1 3271 0.821251296820532 0.851335082070651 1 0.43936505454367 4188 4109 3626 4170 4468 3391 3271 3315 3520 3780 4642 4295 M15253 GO_VIRAL_LATENCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LATENCY.html The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. 13/16 Gene Ontology BP GO:0019042 0.0690322228896266 0.0979729006209144 3505 3628.54545454545 3781 0.00648168569404743 1569 0.538366476995476 0.505548236510234 1 1.84635469377524 3504 4234 3689 4396 1569 3781 3132 2503 4321 4605 4180 4296 M11924 GO_NUCLEAR_PORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. 16/17 Gene Ontology BP GO:0006999 0.0416369893167264 0.0643003356424587 3845 3107.90909090909 3782 0.0038587763714259 643 0.770986749770215 -0.668527582391234 -1 3.13084322070387 3842 2326 3782 1920 1388 3611 3965 4278 643 3907 4525 4297 M11770 GO_POSITIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BINDING.html Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 54/70 Gene Ontology BP GO:0043388 0.389466363986061 0.441243484691294 3780 3545.81818181818 3783 0.0438653566799255 1897 0.953047699014728 -1.04041372688037 -1 1.14712455519708 3780 3726 3331 3854 3817 3783 1897 3011 4176 3803 3826 4298 M10818 GO_RNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_STABILIZATION.html Prevention of degradation of RNA molecules. 38/44 Gene Ontology BP GO:0043489 0.68618940391 0.691390059851284 4635 3609.63636363636 3784 0.1 765 0.907965487068658 -1.18181361727296 -1 0.486882538717101 4632 3080 3522 3297 3443 3784 4394 4562 765 4009 4218 4299 M11674 GO_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPAIR.html Any process that modulates the frequency, rate or extent of DNA repair. 90/109 Gene Ontology BP GO:0006282 0.490319437688096 0.54024540458506 4110 3693.45454545455 3784 0.0594308420870133 2591 0.882403307132206 -0.951385463408931 -1 0.796080683161013 4110 2591 3784 3421 3833 4633 3746 2598 3440 4055 4417 4300 M15033 GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. 28/54 Gene Ontology BP GO:0045581 0.609860378473842 0.655959394599812 3775 3569.63636363636 3785 0.0820094994177889 1716 1.04298557138767 1.03972856438917 1 0.642338066410535 3772 4119 2509 4515 4544 3303 3785 4239 2346 1716 4418 4301 M16217 GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS.html The process in which the branching structure of the salivary gland is generated and organized. 28/33 Gene Ontology BP GO:0060445 0.0242750074918884 0.0415721788221408 3790 3272.90909090909 3786 0.00223155203592241 1189 1.32319076729137 -1.28861996517834 -1 6.23776241994991 2784 3787 1249 3786 1189 4541 3141 4480 4110 2568 4367 4302 M11764 GO_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. 109/145 Gene Ontology BP GO:0019722 0.0419997373277755 0.064753074150477 2545 3171.36363636364 3789 0.00389305930333198 1050 0.9676797771505 -0.922678658532373 -1 3.92221835185752 2542 2055 1050 4135 4188 3789 2279 3840 4273 2871 3863 4303 M10472 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. 15/16 Gene Ontology BP GO:0032211 0.171050535629625 0.212239504609239 3330 3502.90909090909 3790 0.0169095900713232 2000 0.579188125550224 -0.593256982841726 -1 1.32236521540694 3328 4207 3790 4212 2000 3062 2239 2460 4312 4449 4473 4304 M13360 GO_MITOCHONDRIAL_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_PROCESSING.html The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. 12/12 Gene Ontology BP GO:0000963 0.026255792218126 0.0443763898259863 3370 3709.54545454545 3793 0.00241586165931325 1213 0.669185571312022 -0.669185571312022 -1 3.08453215148424 3366 4585 3793 4576 1213 3181 3267 4274 4511 4540 3499 4305 M11147 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 22/37 Gene Ontology BP GO:0055012 0.290172786106098 0.341211517248339 3985 3621.54545454545 3794 0.0306772129834029 2221 1.1718108758585 1.31139611722074 1 1.86021237684192 3983 3495 2466 3370 3483 4622 3988 2221 4282 3794 4133 4306 M15519 GO_CELLULAR_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. 15/17 Gene Ontology BP GO:0006878 0.000156503278563286 0.00104370188530224 4510 3360.81818181818 3794 1.42285829981433e-05 171 0.799939962190085 -0.914524150967537 -1 8.14338941989082 4509 2851 3220 2632 171 4228 3908 3794 3684 3884 4088 4307 M11625 GO_REGULATION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSITIVE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 29/34 Gene Ontology BP GO:0050926 0.188681786966728 0.231767781086639 2995 3349.63636363636 3796 0.0188291053553188 1448 1.41736113580072 1.31664447090816 1 3.06621592283865 2991 3796 1448 4223 4438 3688 2248 4047 3839 2240 3888 4308 M14667 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 7/14 Gene Ontology BP GO:0032740 1.48877674927337e-05 0.000177737040512753 2965 3241.27272727273 3796 1.48878672342036e-06 41 1.13747190377627 1.20467197442279 1 14.5737880274668 2964 4261 4509 4346 41 3880 3796 2842 4291 1811 2913 4309 M12787 GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. 19/20 Gene Ontology BP GO:0000466 0.68618940391 0.691390059851284 4000 3618.72727272727 3797 0.1 2883 0.457482622937355 0.393149058349569 1 0.240027758599682 2921 3172 3996 4041 2883 3797 3099 3335 3998 4521 4043 4310 M11974 GO_PSEUDOURIDINE_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHESIS.html The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. 17/17 Gene Ontology BP GO:0001522 0.68618940391 0.691390059851284 4150 3758 3798 0.1 1483 0.739324146089594 -0.739324146089594 -1 0.394470763573619 4147 3540 3798 3528 4169 4407 3752 3615 1483 4494 4405 4311 M11252 GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. 26/35 Gene Ontology BP GO:0010833 0.68618940391 0.691390059851284 4025 3833.63636363636 3799 0.1 3221 0.734825341624512 -0.854414439449361 -1 0.392005516889573 4022 3799 3931 3608 3527 3771 4180 4451 3221 4154 3506 4312 M16090 GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell. 22/32 Gene Ontology BP GO:1902187 0.0136072657597183 0.0262172288115815 3670 3523.63636363636 3800 0.00124474221908649 737 0.937893725208952 -1.07545515669836 -1 5.06031158080823 3667 4185 3190 3815 4597 3420 4490 737 4195 3800 2664 4313 M14138 GO_REGULATION_OF_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. 17/19 Gene Ontology BP GO:0033127 0.68618940391 0.691390059851284 4595 3766.90909090909 3801 0.1 2437 1.07216000968623 -1.29195991017284 -1 0.576857554426982 4594 4525 3323 3415 4324 4466 4034 2982 2437 3535 3801 4314 M13851 GO_METHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 18/21 Gene Ontology BP GO:0006555 0.000234134382326285 0.00142037455145268 2370 3202.09090909091 3803 2.12872094295837e-05 204 0.633485385339688 0.633485385339688 1 6.15681459040117 2370 3851 3936 4216 204 2546 2177 3803 3867 4559 3694 4315 M13536 GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. 42/46 Gene Ontology BP GO:0070830 0.68618940391 0.691390059851284 3875 3811.63636363636 3804 0.1 2764 0.92174921372513 -0.901757803310749 -1 0.494435720167284 3871 4062 3458 3773 3804 3416 4288 4237 2764 3662 4593 4316 M15218 GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. 15/17 Gene Ontology BP GO:0034314 0.0038533344017972 0.0104912609546883 3800 3464.81818181818 3804 0.000350918197597989 659 0.527150901844895 -0.67451324355405 -1 3.55640188425964 3797 4209 3842 4187 659 3804 3286 2618 3814 4603 3294 4317 M15166 GO_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. 316/378 Gene Ontology BP GO:0033044 0.68618940391 0.691390059851284 3165 3741.81818181818 3806 0.1 2967 0.895112150447513 0.896961312348598 1 0.479839190705393 3161 3629 4154 3892 4131 3175 2967 3806 3464 4335 4446 4318 M12202 GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. 8/10 Gene Ontology BP GO:0006995 0.163992840772855 0.204792991979628 3535 3841.18181818182 3807 0.0177523472632819 2021 0.470939591866865 -0.470939591866865 -1 1.09820101430929 3533 4259 4355 4401 2021 3685 3807 3728 4598 4502 3364 4319 M14031 GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. 8/10 Gene Ontology BP GO:0043562 0.163992840772855 0.204792991979628 3535 3854 3808 0.0177523472632819 2022 0.470939591866865 -0.470939591866865 -1 1.09820101430929 3534 4260 4468 4402 2022 3686 3808 3684 4599 4566 3365 4320 M12440 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD.html The morphogenetic process in which an epithelial sheet bends along a linear axis. 20/25 Gene Ontology BP GO:0060571 0.231176728539767 0.277519431861593 4300 3487.36363636364 3809 0.0236161377027046 1515 1.19548614424679 -1.05748745922061 -1 2.26476650927897 4297 3157 1515 3439 4546 3809 4231 4358 3990 1846 3173 4321 M11707 GO_INSEMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSEMINATION.html The introduction of semen or sperm into the genital tract of a female. 9/18 Gene Ontology BP GO:0007320 0.00596828848998421 0.0137750229880439 3810 3346.45454545455 3810 0.000598437855282443 522 0.965263071628284 -1.27501636034757 -1 6.13067432426563 3810 3262 4321 4137 890 3932 4183 522 4555 3552 3647 4322 M14998 GO_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 87/99 Gene Ontology BP GO:0051225 0.68618940391 0.691390059851284 4350 3663.45454545455 3811 0.1 774 1.09428410548627 -1.31988296286866 -1 0.588981076183014 4563 4348 3811 3579 4223 4095 3284 4349 774 3548 3724 4323 M13744 GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 28/57 Gene Ontology BP GO:2000514 0.667853458041614 0.691390059851284 4020 3337.45454545455 3812 0.0953418055956462 2004 1.44369037033722 -1.70148879138769 -1 0.780448085361611 4019 3782 2004 2163 4538 3857 4354 3812 2016 2171 3996 4324 M14362 GO_GOLGI_RIBBON_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_RIBBON_FORMATION.html The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. 13/13 Gene Ontology BP GO:0090161 0.68618940391 0.691390059851284 4210 3705.90909090909 3813 0.1 1215 0.882427833747165 -0.629969572896753 -1 0.472888461922307 4207 3576 3722 3137 4173 4481 4191 4553 1215 3813 3697 4325 M15480 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. 10/17 Gene Ontology BP GO:0046639 0.246322533189868 0.294032515888264 3750 3866 3813 0.0253806080174033 2165 1.05130963757661 -1.33522971027497 -1 1.90012227320164 3747 4591 3363 4564 2165 4572 4609 3590 3813 3625 3887 4326 M11049 GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. 147/173 Gene Ontology BP GO:0045931 0.68618940391 0.691390059851284 3980 3677.27272727273 3814 0.1 2898 0.978162267517387 -1.02145582201298 -1 0.525348842726327 3976 2975 3814 3423 4182 3344 3383 4418 2898 4096 3941 4327 M13681 GO_ACROSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_ASSEMBLY.html The formation of the acrosome from the spermatid Golgi. 12/18 Gene Ontology BP GO:0001675 0.024613947689722 0.0420906646822038 3970 3418.27272727273 3816 0.00226306587506303 1194 0.683557279734995 -0.694426538209859 -1 3.20467888459861 3966 3238 3565 2876 1194 3816 3939 4373 1538 4553 4543 4328 M15353 GO_SPERMATID_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_DIFFERENTIATION.html The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 113/283 Gene Ontology BP GO:0048515 0.68618940391 0.691390059851284 3950 3784.63636363636 3817 0.1 3318 0.866517430803155 -0.879743206619469 -1 0.464169908270112 3948 3318 3704 3376 4168 3817 3610 4257 3337 4057 4039 4329 M11775 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of hair follicle development. 14/18 Gene Ontology BP GO:0051797 0.20520528578858 0.248869484355877 3820 3513.18181818182 3818 0.020662758113685 2092 1.22382079810768 1.05792287706117 1 2.51669995670142 3818 4226 2238 4397 2092 4426 4472 2696 4051 2789 3440 4330 M13933 GO_NADH_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_METABOLIC_PROCESS.html The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 35/54 Gene Ontology BP GO:0006734 0.0205464036406141 0.0362542344102303 4385 3155 3820 0.00188553083491789 1139 0.850091033724322 -0.748417042903015 -1 4.17644081603782 4383 3437 3820 3836 1139 1331 1606 4491 2409 3935 4318 4331 M10063 GO_CARDIAC_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_ADAPTATION.html The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. 12/17 Gene Ontology BP GO:0014887 0.68618940391 0.691390059851284 4525 3597.90909090909 3822 0.1 1056 1.00224488699152 -0.612274983596994 -1 0.538545592721253 4523 4563 3070 3822 3868 3952 3416 3447 1056 3752 4108 4332 M13340 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 274/356 Gene Ontology BP GO:0090068 0.68618940391 0.691390059851284 4050 3507.81818181818 3822 0.1 1818 1.08409555342193 -1.0966389626907 -1 0.583397971963484 4046 2494 3579 2938 4262 4472 4168 4248 1818 3822 2739 4333 M13848 GO_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLESION_SYNTHESIS.html The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. 46/55 Gene Ontology BP GO:0019985 0.343705103141178 0.396052462832071 2675 3444 3822 0.0375622727970752 1916 0.902034626926102 -0.905250436300479 -1 1.22987147049243 2674 4399 3822 4438 3848 1933 3001 3500 4361 3992 1916 4334 M13805 GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. 12/17 Gene Ontology BP GO:0003299 0.68618940391 0.691390059851284 4525 3597.81818181818 3823 0.1 1057 1.00224488699152 -0.612274983596994 -1 0.538545592721253 4524 4564 3071 3823 3869 3953 3417 3430 1057 3759 4109 4335 M15465 GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 27/29 Gene Ontology BP GO:0032075 0.360310632980421 0.413039018294629 4270 3719.09090909091 3824 0.0398019267484202 2365 0.676126562123928 -0.69237328268702 -1 0.87702808100902 4266 3463 3361 4097 2365 3824 4002 3331 4597 3961 3643 4336 M16881 GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. 12/17 Gene Ontology BP GO:0014898 0.68618940391 0.691390059851284 4525 3600.27272727273 3824 0.1 1058 1.00224488699152 -0.612274983596994 -1 0.538545592721253 4525 4565 3072 3824 3870 3954 3418 3443 1058 3764 4110 4337 M13516 GO_PIGMENT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. 36/41 Gene Ontology BP GO:0050931 0.68618940391 0.691390059851284 4430 3617.45454545455 3828 0.1 2204 1.20414477213608 1.26277684602622 1 0.649182324374082 4428 2204 2282 3580 4280 3828 3744 4438 4111 2746 4151 4338 M14603 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE.html The directed movement of a protein to a specific location in a vacuole. 42/44 Gene Ontology BP GO:0072666 0.00189934441381825 0.0063081010403257 4055 3362.27272727273 3829 0.000172816925038679 506 0.729307008194559 0.742678398182543 1 5.47520702680438 4051 2182 3829 1695 506 3780 4538 3211 4520 4196 4477 4339 M15721 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. 58/65 Gene Ontology BP GO:2001238 0.68618940391 0.691390059851284 3900 3209.45454545455 3830 0.1 1534 1.12112247998115 1.10553449120143 1 0.6036879197994 3897 2627 2586 1648 4062 4090 4361 4264 1534 2405 3830 4340 M15655 GO_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_LOCALIZATION.html Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. 47/54 Gene Ontology BP GO:0051646 0.0350222142314898 0.0558459091223859 4145 3636.45454545455 3831 0.0032356809409229 1327 0.887040295212958 -0.827766037349952 -1 3.78939180055049 4144 4380 3505 4578 1327 3174 3831 3482 4165 4016 3399 4341 M14416 GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. 18/18 Gene Ontology BP GO:2000001 0.68618940391 0.691390059851284 3835 3778 3832 0.1 1129 0.846957756050153 0.800938768724038 1 0.453451633292813 3832 3537 3739 3809 4503 4131 4652 4067 1129 3598 4561 4342 M12925 GO_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. 693/922 Gene Ontology BP GO:0043603 0.316394842851578 0.368599199746718 4070 3348.36363636364 3834 0.0373231393412814 883 1.05448341353181 -0.934947707639756 -1 1.55200548531291 4069 3274 4394 2750 2338 3103 4001 3905 883 4281 3834 4343 M10600 GO_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. 32/41 Gene Ontology BP GO:0031063 0.200613924651443 0.244296412301274 4435 3785 3836 0.0201497923525956 2076 0.715975250867062 -0.6159195215642 -1 1.48764382549908 3726 4434 3512 4590 2076 4503 2878 3065 4431 3836 4584 4344 M10180 GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. 130/154 Gene Ontology BP GO:0002244 0.00964010679834481 0.0200515945161817 3840 3486.81818181818 3837 0.000880237220767389 785 1.25086324721785 -1.22306020740827 -1 7.25042770209922 3837 3655 785 3746 4558 4632 3872 3284 3980 1378 4628 4345 M11583 GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 32/49 Gene Ontology BP GO:0051023 0.46711956809847 0.516517906454891 2805 3711.81818181818 3837 0.0556169989521125 2536 0.812288065567021 -0.858078335191668 -1 0.786147977184808 2802 4446 3340 4443 2536 3137 4413 4038 4554 3837 3284 4346 M11982 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 37/45 Gene Ontology BP GO:0071353 0.0845140069081178 0.116103830570851 3875 3446.36363636364 3838 0.00799515957383573 1518 1.02419741767171 0.62410803135101 1 3.26394266987438 3875 4415 2774 4042 3838 3266 2703 1518 3994 3474 4011 4347 M12715 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX.html The joining of the small ribosomal subunit, ternary complex, and mRNA. 22/23 Gene Ontology BP GO:0001731 0.00349753718888055 0.00982731916658286 4180 3420.72727272727 3838 0.000318464540409302 632 0.454812284417997 -0.325540684510691 -1 3.11105912409961 2253 4179 4075 4100 632 2899 3838 3719 4177 4519 3237 4348 M11412 GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. 1467/2173 Gene Ontology BP GO:0051172 0.364158854959605 0.417142085703358 2320 3461.90909090909 3839 0.0442707830101507 2097 1.02214720298749 0.997383684036103 1 1.31631839999106 2316 4610 4298 4558 2427 2898 2097 3839 2672 4230 4136 4349 M10723 GO_MEMBRANE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DISASSEMBLY.html The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. 54/57 Gene Ontology BP GO:0030397 0.68618940391 0.691390059851284 3785 3711.18181818182 3844 0.1 1001 0.844220472007592 -0.786739341989629 -1 0.451951661364362 3783 3727 4017 3404 3844 4606 4462 3734 1001 4278 3967 4350 M12546 GO_ER_NUCLEUS_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_NUCLEUS_SIGNALING_PATHWAY.html Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. 46/50 Gene Ontology BP GO:0006984 0.0131469436247316 0.025563196274917 3315 3532 3844 0.00120237926070572 993 0.936915995696922 0.838770917418178 1 5.09017027780679 3314 4059 3315 3431 993 3844 3981 3868 4047 3542 4458 4351 M15629 GO_NUCLEAR_ENVELOPE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_DISASSEMBLY.html The controlled breakdown of the nuclear envelope in the context of a normal process. 54/57 Gene Ontology BP GO:0051081 0.68618940391 0.691390059851284 3785 3714.18181818182 3845 0.1 1002 0.844220472007592 -0.786739341989629 -1 0.451951661364362 3784 3728 4018 3405 3845 4607 4463 3756 1002 4280 3968 4352 M13037 GO_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_CYCLE.html The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. 57/66 Gene Ontology BP GO:0007098 0.684288023924845 0.691390059851284 4105 3552.72727272727 3847 0.0995056232876452 932 0.809298786413708 -0.818067888149003 -1 0.4328153396416 4101 3357 3985 3177 2877 4365 3847 4423 932 4304 3712 4353 M11823 GO_NAD_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 51/75 Gene Ontology BP GO:0019674 0.00896892990213996 0.0189606682574544 4645 3395.18181818182 3851 0.000818700397740719 881 0.922570984847943 0.993392888749688 1 5.42136860197341 4641 4378 3745 4232 881 1499 2138 3566 3851 3901 4515 4354 M13953 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. 38/41 Gene Ontology BP GO:1904358 0.68618940391 0.691390059851284 4480 3535.09090909091 3853 0.1 162 1.2330957956894 -0.879110908584982 -1 0.665046853577009 4476 3406 3610 2718 4547 4040 4182 3853 162 3788 4104 4355 M10901 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. 24/29 Gene Ontology BP GO:2000144 0.00807863617157008 0.0174597420256295 3785 3637.63636363636 3855 0.000737132291096404 854 0.877106529301532 0.850991420546886 1 5.26108096536383 3785 3488 3544 3159 854 4634 3855 4610 3978 3857 4250 4356 M11462 GO_DETECTION_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_OTHER_ORGANISM.html The series of events in which a stimulus from another organism is received and converted into a molecular signal. 31/63 Gene Ontology BP GO:0098543 0.340263576488668 0.392475563064396 3690 3739 3861 0.0371045536262921 2320 0.88623665125123 1.01432854918156 1 1.22008359055839 3689 4126 2777 4418 3861 3907 3530 2320 4378 3518 4605 4357 M12136 GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 16/22 Gene Ontology BP GO:0002082 0.68618940391 0.691390059851284 4055 3618.18181818182 3863 0.1 1720 1.01262834569789 -0.973073420533707 -1 0.544235501527798 4052 4194 3168 3047 4589 3863 4147 4559 1720 2993 3468 4358 M10447 GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. 72/77 Gene Ontology BP GO:2000573 0.68618940391 0.691390059851284 4170 3737.27272727273 3864 0.1 1393 1.04881304499193 -0.801538479982084 -1 0.564063927199593 4170 4020 3569 3676 4497 3864 4367 4195 1393 3516 3843 4359 M16351 GO_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_KILLING.html Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. 66/138 Gene Ontology BP GO:0031341 0.450350535545717 0.499756985903702 4640 3727.63636363636 3864 0.0529532082232128 1752 1.00755830934968 1.1531498096538 1 1.02704933450248 4638 4031 1752 4020 3747 3791 4620 3042 4435 3064 3864 4360 M15012 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 101/120 Gene Ontology BP GO:0071158 0.68618940391 0.691390059851284 4225 3549.18181818182 3865 0.1 2067 1.03253326683498 -0.919828449655049 -1 0.555142963990389 4223 2067 3442 4183 3293 4374 3994 3938 2190 3865 3472 4361 M16577 GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING.html The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. 58/65 Gene Ontology BP GO:0061077 0.737218817288219 0.742002845953295 3870 3773.81818181818 3866 0.114403600725213 2622 0.870099428557368 -0.721735852826291 -1 0.37485790206692 3866 4372 3805 4473 3168 2755 2622 3858 4481 4164 3948 4362 M16744 GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION.html A cellular localization which involves only one organism. 1005/1309 Gene Ontology BP GO:1902580 0.217090699543114 0.261893446972805 3975 3762 3867 0.0241767863825094 2154 0.973280137912362 -0.962876851222316 -1 1.92558200234355 3972 3616 4645 3867 2154 4325 3715 4338 2756 4358 3636 4363 M16081 GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. 57/60 Gene Ontology BP GO:1904356 0.68618940391 0.691390059851284 3955 3539.45454545455 3868 0.1 319 1.10231426166157 -0.831468587627773 -1 0.593381426551021 4199 3721 3954 3868 3156 4097 3955 3759 319 4151 3755 4364 M13105 GO_MATURATION_OF_LSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_LSU_RRNA.html Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. 14/17 Gene Ontology BP GO:0000470 0.4237999908775 0.475052121790654 4535 3620 3870 0.048883024967432 1973 0.361739406634358 0.361739406634358 1 0.389133325072581 2570 4231 3870 4560 3878 3120 1973 2873 4532 4533 3680 4365 M16439 GO_DOPAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_TRANSPORT.html The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 6/13 Gene Ontology BP GO:0015872 0.855633372507277 0.859327019701351 4255 3932.54545454545 3870 0.175963059256378 3224 0.652039163913543 -0.652039163913543 -1 0.136116974893597 4253 3267 4622 3552 3224 4192 3870 3472 4538 4638 3630 4366 M10698 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 12/14 Gene Ontology BP GO:0034244 0.631709181364489 0.677424019564178 3875 3946.09090909091 3873 0.0868065067167505 2793 0.482820790287596 -0.54672346030243 -1 0.268542260637398 3873 4562 3789 4385 2793 3806 3902 3514 4469 4453 3861 4367 M12178 GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 27/29 Gene Ontology BP GO:0034243 0.68618940391 0.691390059851284 4175 3753.36363636364 3873 0.1 2825 0.580924802585836 0.495619881417606 1 0.307671379568711 4175 3124 4029 3644 3509 3837 3999 3873 2825 4171 4101 4368 M11206 GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. 203/249 Gene Ontology BP GO:0051054 0.68618940391 0.691390059851284 4000 3725.72727272727 3874 0.1 2028 0.966083968956606 -0.940352183393093 -1 0.518730198660556 3997 3971 3874 3682 4264 4318 3555 3234 2028 3532 4528 4369 M14060 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. 14/15 Gene Ontology BP GO:0044794 0.0125432752432282 0.0245742567186278 4590 3594.81818181818 3874 0.00114685151694525 974 1.11530581958053 -1.33304541817646 -1 6.12671222724671 4588 4219 3242 4038 974 4104 4429 3874 2958 3365 3752 4370 M11260 GO_TELOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. 89/120 Gene Ontology BP GO:0032200 0.68618940391 0.691390059851284 2940 3732.18181818182 3875 0.1 2677 0.928603388818553 -1.08492711330131 -1 0.498191658562047 2940 4345 3875 4413 4159 2902 4146 3801 3499 4297 2677 4371 M10992 GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. 15/16 Gene Ontology BP GO:0045910 0.647099042400825 0.691390059851284 2960 3633.54545454545 3876 0.0903432832484241 2435 0.488740949329149 -0.488740949329149 -1 0.257156639413305 2956 4554 3876 4442 4028 2897 2435 3125 4573 4461 2622 4372 M12437 GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of granulocyte differentiation. 15/21 Gene Ontology BP GO:0030852 0.170945394427845 0.212165622905512 3630 3501.90909090909 3876 0.0168982550949605 1908 0.8197056801912 -0.85309076078112 -1 1.87635112508597 3626 3906 2999 3964 2848 4094 3934 1908 4564 3876 2802 4373 M13952 GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE.html Any process that modulates the frequency, rate or extent of stem cell population maintenance. 16/22 Gene Ontology BP GO:2000036 0.135466497931049 0.173595597596577 3755 3838.45454545455 3879 0.0131460280904281 1882 0.511097684080305 -0.511097684080305 -1 1.31817956109006 3752 3879 3816 4070 1882 3743 3330 4126 4501 4565 4559 4374 M15006 GO_REGULATION_OF_TRANSLATIONAL_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_FIDELITY.html Any process that modulates the ability of the translational apparatus to interpret the genetic code. 16/16 Gene Ontology BP GO:0006450 0.68618940391 0.691390059851284 3350 3747.63636363636 3880 0.1 2624 0.50993037524453 -0.50874028674896 -1 0.268767982466814 3347 4204 3880 4224 3953 3087 2624 3254 4194 4591 3866 4375 M10088 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR.html Any process that modulates the frequency, rate or extent of double-strand break repair. 43/48 Gene Ontology BP GO:2000779 0.68618940391 0.691390059851284 3090 3783.90909090909 3881 0.1 3062 0.887234367378999 0.672037865503062 1 0.475522337475157 3089 4394 3794 4582 3296 3901 3406 3062 3881 4208 4010 4376 M14895 GO_CELL_MIGRATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_IN_HINDBRAIN.html The orderly movement of a cell that will reside in the hindbrain. 15/24 Gene Ontology BP GO:0021535 0.0984438598159494 0.132119780710589 4040 3516.72727272727 3881 0.00937693829139372 1734 0.68295759906368 -0.749085402609775 -1 2.04187391441261 4039 3203 3385 2893 1734 4284 3987 4645 2136 3881 4497 4377 M11789 GO_SEQUESTERING_OF_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUESTERING_OF_METAL_ION.html The process of binding or confining metal ions such that they are separated from other components of a biological system. 12/22 Gene Ontology BP GO:0051238 0.00848054791376711 0.018159222016916 3885 3675.54545454545 3882 0.00077394692739412 867 1.0984112454526 -0.961941911490395 -1 6.52714134051804 3882 4580 2531 4399 867 4571 3708 3623 4533 3190 4547 4378 M16780 GO_MITOTIC_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CHROMOSOME_CONDENSATION.html The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. 15/15 Gene Ontology BP GO:0007076 0.633627666815496 0.679324777348503 3585 3768.09090909091 3884 0.0872399859150961 2276 0.588099290827589 -0.615447576933848 -1 0.32697585497887 3584 4568 3884 4596 3341 2276 2418 3453 4371 4650 4308 4379 M16240 GO_PEPTIDYL_LYSINE_DIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_DIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. 15/15 Gene Ontology BP GO:0018027 0.582322764395667 0.629541780374777 4600 3783.36363636364 3885 0.0762999176341684 2722 0.7323427989108 -0.815393985039344 -1 0.492547914618715 4597 4220 3853 4227 4163 4210 3736 2726 2722 3885 3278 4380 M14685 GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. 381/456 Gene Ontology BP GO:0034248 0.68618940391 0.691390059851284 3185 3765.54545454545 3888 0.1 2329 0.908233602715775 -0.883614518870137 -1 0.487029460241503 3184 3958 4161 3888 3442 4266 3588 3699 2329 4277 4629 4381 M15005 GO_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 504/763 Gene Ontology BP GO:0043900 0.6513215599 0.691390059851284 4070 3944.72727272727 3889 0.1 3352 1.03259883728672 -0.953511902798244 -1 0.555178895167209 4068 4280 4529 4320 3607 3529 4393 3889 3352 3578 3847 4382 M11741 GO_HISTONE_H2A_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_MONOUBIQUITINATION.html The modification of histone H2A by addition of a single ubiquitin group. 15/15 Gene Ontology BP GO:0035518 0.178194707613856 0.220106178531264 4010 3396.27272727273 3892 0.0176828615057812 1334 0.409895686651578 -0.399166523655405 -1 0.91058019784301 4010 3892 3937 4537 2069 1963 1334 3845 4092 4486 3194 4383 M16564 GO_RNA_INTERFERENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_INTERFERENCE.html The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. 12/12 Gene Ontology BP GO:0016246 0.244756034733686 0.292462719469913 2975 3533.45454545455 3892 0.0251966253769533 1545 0.184379096164295 0.250081664140768 1 0.325917029162379 2973 4597 3892 4607 4437 2233 1545 2359 4429 4642 3154 4384 M11299 GO_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT.html The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. 168/210 Gene Ontology BP GO:0017038 0.68618940391 0.691390059851284 4460 3867.63636363636 3893 0.1 3108 0.857160721666486 -0.757010973023849 -1 0.459042635824336 4459 3300 4098 3449 3461 3422 4532 4595 3108 4227 3893 4385 M14569 GO_REGULATION_OF_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_ORGANIZATION.html Any process that modulates the frequency, rate or extent of chromatin organization. 180/225 Gene Ontology BP GO:1902275 0.426231878952087 0.47754802137348 1980 3314.18181818182 3893 0.0492486586350506 1977 0.900593944678329 0.843163666694069 1 0.977670507138336 1977 3979 3960 3893 4215 2132 1979 2922 4100 4243 3056 4386 M11418 GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. 16/21 Gene Ontology BP GO:0019359 0.52614199434503 0.575929646070047 3900 3693 3898 0.0656416420780342 2433 0.882836157129425 0.744585753752444 1 0.712631061483803 3898 4215 3207 3975 3504 3882 4426 2650 4527 3906 2433 4387 M16385 GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. 16/21 Gene Ontology BP GO:0019363 0.535485549500795 0.584885976954741 3900 3696.90909090909 3899 0.0673317286997558 2434 0.882836157129425 0.744585753752444 1 0.692402623938042 3899 4216 3208 3976 3505 3883 4427 2666 4528 3924 2434 4388 M14837 GO_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATPASE_ACTIVITY.html Any process that modulates the rate of ATP hydrolysis by an ATPase. 89/124 Gene Ontology BP GO:0043462 0.163799407034496 0.204661289186764 4460 3458.90909090909 3900 0.0161309124650912 1137 1.00267823165064 1.04662699323708 1 2.35117859605929 4458 4349 3359 4594 2086 1137 3087 4598 4236 3900 2244 4389 M13321 GO_REGULATION_OF_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 19/23 Gene Ontology BP GO:0044030 0.68618940391 0.691390059851284 3905 3896.36363636364 3901 0.1 3194 0.613867812758406 0.613867812758406 1 0.325723430334809 3901 3846 3914 4255 3194 3860 4649 3300 3439 4538 3964 4390 M13628 GO_DNA_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION.html The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. 30/31 Gene Ontology BP GO:0022616 0.68618940391 0.691390059851284 2815 3831.81818181818 3903 0.1 2811 0.683229859553315 -0.687553000775944 -1 0.363732318515428 2811 4112 3871 4325 4526 3146 3903 4425 3277 4200 3554 4391 M15250 GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME.html The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. 19/23 Gene Ontology BP GO:0045292 0.68618940391 0.691390059851284 3675 3962.36363636364 3903 0.1 3178 0.560693554776744 0.607844403863944 1 0.296585097210235 3674 3863 3903 3642 3178 4435 4398 4160 3500 4604 4229 4392 M10863 GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL.html The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 28/53 Gene Ontology BP GO:0086010 0.0227533207639744 0.0393866077063887 2835 3620.45454545455 3905 0.00209019180809481 929 1.22227702168454 -1.48304968844713 -1 5.85923624822445 2831 4140 929 4538 3905 4597 3033 3305 4350 3686 4511 4393 M11451 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. 11/12 Gene Ontology BP GO:0070202 0.488023876485734 0.538225905970164 3345 3761.45454545455 3906 0.0590465146554815 2591 0.92661768668692 0.92661768668692 1 0.841656784137571 3345 3923 3795 3827 4186 4378 4337 2591 2611 4477 3906 4394 M12643 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. 14/15 Gene Ontology BP GO:0071459 0.250593367225802 0.298670834452268 4300 3440.09090909091 3907 0.0258839820003283 279 1.6254437754956 1.6254437754956 1 2.90585176775317 4296 3907 3289 2885 2176 4545 4253 4008 279 3850 4353 4395 M15747 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 11/18 Gene Ontology BP GO:2000515 0.0623335582301681 0.0897229446119802 3420 3789.18181818182 3907 0.0058339161450967 1533 0.814417390269168 -0.861445215660088 -1 2.90492527532208 3416 4579 3302 4393 1533 3858 4080 3907 4171 4615 3827 4396 M13082 GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. 6/22 Gene Ontology BP GO:0010896 0.0092016738075545 0.0193822490839978 4080 3173.81818181818 3908 0.000923999920720952 642 0.884183425150516 -1.15340106052945 -1 5.16647439153392 4078 1869 4406 2780 3912 3908 4568 642 1438 3304 4007 4397 M15933 GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING.html The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. 20/23 Gene Ontology BP GO:0000729 0.031387313125899 0.0508912627487436 2745 3497 3908 0.00289493347921543 1049 0.714606450396742 0.714606450396742 1 3.1492689266703 2741 4177 3908 4239 4386 3333 2714 1049 4046 4622 3252 4398 M12196 GO_BASE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASE_EXCISION_REPAIR.html In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. 41/43 Gene Ontology BP GO:0006284 0.0768656160891155 0.107048385490523 4445 3215.54545454545 3910 0.00724458152824172 888 0.730351631776645 -0.730351631776645 -1 2.41250849873981 2190 4410 3910 4444 4338 1218 2170 3077 4443 4283 888 4399 M12423 GO_NCRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_PROCESSING.html Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. 412/510 Gene Ontology BP GO:0034470 0.43591469091506 0.486055848748567 1925 3571 3911 0.050718579573121 1924 0.71679656311119 -0.712792302252009 -1 0.757172241234886 1924 4631 4209 4651 2496 3411 2406 3039 4094 4509 3911 4400 M12724 GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of natural killer cell activation. 22/34 Gene Ontology BP GO:0032814 0.141744682670437 0.180201641657253 3610 3498.36363636364 3911 0.0137996856712687 1811 1.08810995012676 1.119164341089 1 2.75805663929092 3609 4163 2376 4349 2196 4201 3911 1811 4401 3421 4044 4401 M12981 GO_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. 190/204 Gene Ontology BP GO:0000819 0.64908258353696 0.691390059851284 2660 3706.72727272727 3912 0.090809282627555 2224 0.841963331760691 -0.91225472003103 -1 0.450714797759311 2659 4647 4187 4292 2823 3912 4371 3894 2224 4390 3375 4402 M15405 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. 20/38 Gene Ontology BP GO:1901984 0.43119990772354 0.48137552078638 4645 3505.36363636364 3912 0.05 408 0.775938898334036 0.706174317232029 1 0.831673634726428 4642 408 3594 1670 3920 3496 4369 3912 3904 4053 4591 4403 M12704 GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 35/39 Gene Ontology BP GO:0042558 0.68618940391 0.691390059851284 4335 3501.45454545455 3915 0.1 1052 1.32912539824405 1.22105670084953 1 0.71766898043438 4334 4090 2994 3915 4652 2683 3005 3937 1052 3400 4454 4404 M16738 GO_V_D_J_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_V_D_J_RECOMBINATION.html The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). 14/17 Gene Ontology BP GO:0033151 0.89622313222392 0.898927836653999 3915 3993.63636363636 3915 0.186130832148512 3302 0.716707412215894 -0.49316532396323 -1 0.102729244510328 3915 4546 3423 4523 4277 4351 3519 3302 4470 3854 3750 4405 M12063 GO_PEPTIDYL_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_AMINO_ACID_MODIFICATION.html The alteration of an amino acid residue in a peptide. 830/1025 Gene Ontology BP GO:0018193 0.6513215599 0.691390059851284 2960 3728.09090909091 3916 0.1 2643 1.00175534035866 1.03717798277725 1 0.538277331848236 2958 3272 4341 4193 4096 3801 3114 3916 2643 4204 4471 4406 M14695 GO_HISTONE_H2A_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_ACETYLATION.html The modification of histone H2A by the addition of an acetyl group. 16/18 Gene Ontology BP GO:0043968 0.574775257171739 0.622684347292224 4295 3850.18181818182 3916 0.0747948363853945 2694 0.800315962097324 -1.19466029888333 -1 0.552269153198505 4293 4214 3783 4278 2694 4530 3829 3122 4578 3916 3115 4407 M15215 GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. 11/11 Gene Ontology BP GO:0070525 0.510215440999364 0.560177547656923 2470 3568.36363636364 3917 0.0628294245712021 1995 0.560558464044069 -0.560558464044069 -1 0.471676069677349 2466 3928 3645 4524 4091 1995 2968 3917 4488 4602 2628 4408 M15578 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. 21/31 Gene Ontology BP GO:2000353 0.010959272157386 0.0221614486520282 3920 3178.81818181818 3918 0.00100129540301864 931 1.66048534175907 -1.49950383042934 -1 9.38156189937133 3918 3827 1064 4133 931 3976 4455 2011 4162 1944 4546 4409 M15455 GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. 58/69 Gene Ontology BP GO:0034637 0.43119990772354 0.48137552078638 4505 2946.72727272727 3919 0.05 152 1.20610303187372 -1.05780387139779 -1 1.29864712465332 4504 152 2336 990 4448 4004 4115 3919 1132 2404 4410 4410 M11831 GO_MRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. 11/13 Gene Ontology BP GO:0016556 0.0055802605751446 0.0134540021460564 4470 3560.90909090909 3921 0.000508587752155117 755 1.17670251903243 -1.17670251903243 -1 7.5171248773988 4470 3921 3618 4005 755 4588 4482 2043 3316 3673 4299 4411 M16080 GO_NEURONAL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ACTION_POTENTIAL.html An action potential that occurs in a neuron. 16/51 Gene Ontology BP GO:0019228 0.094915320829982 0.127974786387107 4050 3314.09090909091 3922 0.00902509723847619 1579 0.798194250451093 -0.79865491069032 -1 2.42598058050117 4049 4208 2096 4526 1740 2443 4266 1579 4607 3922 3019 4412 M16568 GO_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_AGING.html Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 46/53 Gene Ontology BP GO:0090342 0.393621752728337 0.445517396118938 4440 3728.36363636364 3923 0.0444587952493302 2430 0.911526408129946 -0.977281509584717 -1 1.08363677454323 4440 4055 3203 4563 2430 4491 3176 3439 3923 3994 3298 4413 M11926 GO_INTRA_S_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_S_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. 11/13 Gene Ontology BP GO:0031573 0.00464002911935755 0.0119150416624562 4235 3472 3924 0.000422713128940455 672 0.741694842590251 -0.488740949329149 -1 4.86800421837714 4233 3924 3685 3789 717 4324 3456 4348 672 4492 4552 4414 M14330 GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of T cell mediated immunity. 53/118 Gene Ontology BP GO:0002709 0.453857043589904 0.503168173415254 3930 3885.72727272727 3928 0.0535040545323066 2523 0.873647622502193 0.980398643209293 1 0.88030669705114 3928 4377 3396 4450 3271 4240 3692 2523 4563 3774 4529 4415 M11479 GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. 14/22 Gene Ontology BP GO:0051131 0.871940325809375 0.875515394042085 3135 3905.81818181818 3929 0.17042496880082 3135 0.77979917991579 0.77979917991579 1 0.143267341025501 3135 4230 3747 3446 3929 4292 4276 3255 4636 4479 3539 4416 M12928 GO_PARENTAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARENTAL_BEHAVIOR.html A reproductive behavior in which a parent cares for and rears offspring. 10/16 Gene Ontology BP GO:0060746 0.00878178547416552 0.0186324729082773 3065 3639.90909090909 3929 0.000801548824280573 876 0.63150185507439 0.659524141754877 1 3.7239471294872 4145 4252 3064 3995 876 3867 3065 3693 4626 4527 3929 4417 M13927 GO_MATERNAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_BEHAVIOR.html Female behaviors associated with the care and rearing of offspring. 10/16 Gene Ontology BP GO:0042711 0.00878178547416552 0.0186324729082773 4150 3642.54545454545 3930 0.000801548824280573 877 0.63150185507439 0.659524141754877 1 3.7239471294872 4146 4253 3065 3996 877 3868 3066 3677 4627 4563 3930 4418 M15825 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION.html The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. 26/30 Gene Ontology BP GO:0040001 0.821142753338243 0.825221864207958 4285 3931 3930 0.144842617753565 3105 0.911489276574472 -0.784029773455404 -1 0.249330735941551 4283 4486 3590 4372 3105 3649 3534 3241 4498 3930 4553 4419 M10642 GO_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION.html A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 104/129 Gene Ontology BP GO:0006261 0.68618940391 0.691390059851284 2120 3582.90909090909 3931 0.1 2118 0.791375504873634 -0.813877598350806 -1 0.422993772439284 2118 4332 4124 4388 4179 2688 2823 3931 3173 4317 3339 4420 M12955 GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. 151/264 Gene Ontology BP GO:1903707 0.385118736138843 0.437276105235246 4045 3456.72727272727 3931 0.0432483818098066 1680 1.08515902500311 1.09397957389759 1 1.32216994677842 4043 3984 1680 3980 3375 4518 3931 3168 3357 1748 4240 4421 M12669 GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. 16/21 Gene Ontology BP GO:0046500 0.0212892361790374 0.0373243466243636 4430 3776.72727272727 3932 0.00195437140887631 1153 1.05309635605148 -1.14594943511591 -1 5.13085220574211 4429 4555 3770 4583 1153 3607 3943 3321 4341 3910 3932 4422 M13676 GO_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the cell cycle. 1059/1342 Gene Ontology BP GO:0051726 0.6513215599 0.691390059851284 4420 3430.72727272727 3934 0.1 1281 0.971875952408679 -0.962315701219461 -1 0.521904079212622 4420 1281 4441 2394 3934 4562 3594 3969 2020 4045 3078 4423 M11110 GO_NCRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of a non-coding RNA molecule. 20/22 Gene Ontology BP GO:0043628 0.557115443311524 0.60595094851064 3525 3652.45454545455 3935 0.0713659704007132 2262 0.593198550542442 -0.593198550542442 -1 0.430579014386714 3522 2813 3935 4018 4415 2818 2262 4080 4152 4464 3698 4424 M11745 GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. 22/25 Gene Ontology BP GO:0044818 0.0158700379555681 0.0296083747422848 2380 2987.18181818182 3939 0.00145324441641219 315 0.910736847697943 0.910736847697943 1 4.74898751506231 2378 4165 3969 4276 4292 792 315 1069 3939 4487 3177 4425 M13742 GO_MITOTIC_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. 90/105 Gene Ontology BP GO:0007052 0.510938755193442 0.560839355488342 3420 3737 3941 0.0629553285816598 2148 1.05161702447372 -1.23305572591614 -1 0.892369231825816 3420 4346 3831 4532 4093 4117 4575 3787 2148 3941 2317 4426 M13491 GO_REGULATION_OF_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_CYCLE.html Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. 47/54 Gene Ontology BP GO:0046605 0.68618940391 0.691390059851284 4555 3877.45454545455 3943 0.1 2436 0.787512512060396 -0.742804012899555 -1 0.420876936667193 4551 3376 3943 4204 3890 4354 4495 3512 2436 4242 3649 4427 M16295 GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. 17/20 Gene Ontology BP GO:0000028 0.507318958870393 0.557128892051909 2745 3696 3945 0.0623269349256678 2153 0.456728763898864 -0.542473281569083 -1 0.386035498095259 2743 4552 3945 4612 2938 2656 2153 4372 4643 4632 3410 4428 M16567 GO_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. 52/56 Gene Ontology BP GO:0051972 0.184719357564522 0.227380733002043 4115 3538.81818181818 3945 0.0183944349394273 1670 1.06989771540203 -0.914545288455925 -1 2.34228347543954 4113 4043 3587 4071 2034 4002 3758 4225 1670 3945 3479 4429 M10585 GO_FOREBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 9/20 Gene Ontology BP GO:0048853 0.204475208583011 0.248283701862409 4000 3029 3946 0.0226156701041107 786 1.48619704105428 -1.13029263674507 -1 3.06374424634979 3999 2405 4249 1153 2128 4105 4637 4448 786 1463 3946 4430 M12348 GO_ERROR_FREE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_FREE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. 22/26 Gene Ontology BP GO:0070987 0.819000945811279 0.823247224208227 3395 3910.45454545455 3946 0.143916694848465 3098 0.610478557240943 -0.642835775103537 -1 0.165641971941083 3395 4164 3946 4421 3098 3533 3565 4150 4553 4507 3683 4431 M11322 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_ELONGATION.html Any process that modulates the frequency, rate, extent or accuracy of translational elongation. 25/25 Gene Ontology BP GO:0006448 0.0111023958673999 0.0224119080134542 3815 3784.45454545455 3947 0.00101443851529061 932 0.642909713859181 0.743536784191847 1 3.61510765274704 3940 3812 3947 3814 932 4531 4185 4271 3368 4473 4356 4432 M14218 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. 61/67 Gene Ontology BP GO:0000288 0.102367131477294 0.136501455071842 2205 3639 3947 0.00976961210075276 1755 0.676540959239125 -0.512141755958484 -1 1.98981484363051 2203 4359 4140 4440 1755 3947 3675 4173 3378 4363 3596 4433 M10348 GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 6/15 Gene Ontology BP GO:0035589 0.294563463291491 0.345762813999826 1485 3450.81818181818 3948 0.034292076080125 1481 0.61494102161458 0.61494102161458 1 0.959033319167908 1481 3948 4235 4184 4308 2655 2565 2270 4646 4447 3220 4434 M14436 GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. 22/59 Gene Ontology BP GO:0046597 0.68618940391 0.691390059851284 4580 3812.63636363636 3951 0.1 2531 1.11812348744185 -1.00357048089971 -1 0.602044537325156 4580 4506 2816 3951 4436 3481 3422 4043 3919 2531 4254 4435 M16025 GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. 32/37 Gene Ontology BP GO:0044803 0.0910170432608647 0.123488544181888 4270 3472.72727272727 3951 0.00863783534611201 1250 0.795887320488582 0.880781926493852 1 2.46110908660252 4269 4097 3825 4016 1701 3951 2996 3808 1250 4225 4062 4436 M13508 GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. 236/273 Gene Ontology BP GO:0045930 0.562730762261113 0.611058631692172 3955 3676.81818181818 3953 0.0724425640008586 2041 1.03126377084186 -1.01095613311985 -1 0.743574056339773 3953 4637 3956 3847 4027 4003 3776 3622 2041 4152 2431 4437 M16125 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST.html Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. 134/211 Gene Ontology BP GO:0050691 0.624078896529478 0.669704590763759 3945 3702 3953 0.0851025273280952 2376 1.21685788268159 -1.12861684210623 -1 0.713727793201747 3944 4315 2616 4514 4006 2376 4160 2801 3953 3569 4468 4438 M13353 GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION.html Any recombinational process that contributes to the maintenance of proper telomeric length. 32/33 Gene Ontology BP GO:0000722 0.68618940391 0.691390059851284 3730 4016.81818181818 3955 0.1 3727 0.631843421680107 -0.60613994781784 -1 0.335573671800487 3727 3778 3938 4344 3866 4222 3980 3955 3828 4539 4008 4439 M13550 GO_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. 583/846 Gene Ontology BP GO:0006325 0.6513215599 0.691390059851284 4575 3861.63636363636 3957 0.1 2203 0.925119427200331 -1.05265471339812 -1 0.496282523614456 4573 3957 4434 3879 3407 4429 4153 3895 2203 4353 3195 4440 M10217 GO_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_RECOMBINATION.html Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. 57/91 Gene Ontology BP GO:0000018 0.68618940391 0.691390059851284 3175 3826.09090909091 3958 0.1 2892 0.872839204778189 0.83378924506847 1 0.467634102468861 3174 4366 3958 4581 4244 3839 3239 4122 2892 4038 3634 4441 M13244 GO_COVALENT_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COVALENT_CHROMATIN_MODIFICATION.html The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. 342/403 Gene Ontology BP GO:0016569 0.68618940391 0.691390059851284 3060 3759.72727272727 3959 0.1 3056 0.81264950665842 0.723864135071641 1 0.434651461223801 3056 3959 4197 4300 3127 3142 3079 4524 3360 4406 4207 4442 M16958 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 58/73 Gene Ontology BP GO:0090502 0.0310951093556544 0.0505893509901608 3520 3502.36363636364 3959 0.00286759185215782 1041 0.828401711227794 -0.659571183395773 -1 3.65978122647872 3518 4369 3959 4577 2067 4348 3762 1041 2514 4165 4206 4443 M10769 GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein. 144/160 Gene Ontology BP GO:0042787 0.68618940391 0.691390059851284 3705 3972.27272727273 3962 0.1 3308 0.813739319386658 -0.713551396552563 -1 0.435248654819427 3704 3308 4145 3820 3962 3924 4229 4346 3391 4296 4570 4444 M16039 GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 27/31 Gene Ontology BP GO:1902176 0.255901310042385 0.304607008346691 4615 3804.27272727273 3962 0.0265132403316632 2185 0.851538389047396 -0.825436070249705 -1 1.49235884651359 4615 3462 3448 3864 2185 3424 4581 4035 4036 3962 4235 4445 M15180 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 30/31 Gene Ontology BP GO:0032205 0.102642955502102 0.136729937575516 4530 3760.63636363636 3963 0.00979727754037253 1759 0.565732744461606 -0.533862166789407 -1 1.66075891884168 4527 3459 4055 4274 1759 3963 3794 2931 4077 4600 3928 4446 M14732 GO_HISTONE_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving an mRNA encoding a histone. 28/31 Gene Ontology BP GO:0008334 0.432885557592568 0.483025539443218 3575 3797.18181818182 3964 0.0502562856924882 2492 0.521984838712188 -0.577990855428679 -1 0.553336462797857 3571 4128 4066 4561 2492 3233 3428 3964 4124 4585 3617 4447 M12475 GO_LONG_TERM_SYNAPTIC_DEPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_DEPRESSION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. 17/24 Gene Ontology BP GO:0060292 0.571459093496618 0.619380191483756 3535 3630.27272727273 3968 0.0741412120931568 2292 0.911999656536307 -0.946831917792347 -1 0.638030766151537 3532 4526 2858 4534 4440 2292 2912 4014 4405 3968 2452 4448 M15903 GO_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 1708/2159 Gene Ontology BP GO:0033554 0.6513215599 0.691390059851284 4375 3768.18181818182 3968 0.1 2628 1.02603980048401 -1.02581539669623 -1 0.55158468611591 4375 3953 4580 3968 3379 2628 4526 4296 2740 4254 2751 4449 M16267 GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 224/307 Gene Ontology BP GO:0040029 0.68618940391 0.691390059851284 4035 3721.27272727273 3970 0.1 2356 1.09277583340887 -1.15637345780257 -1 0.588154575994729 4035 3970 3952 4295 2916 4145 3211 4009 2356 4084 3961 4450 M13444 GO_MALE_MEIOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. 35/155 Gene Ontology BP GO:0007140 0.68618940391 0.691390059851284 4250 3749.27272727273 3971 0.1 2639 1.27446728977094 0.94905090403414 1 0.687717529617754 4249 4436 2639 4384 3572 3296 3083 4089 3971 3044 4479 4451 M16704 GO_METAPHASE_PLATE_CONGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAPHASE_PLATE_CONGRESSION.html The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. 51/51 Gene Ontology BP GO:0051310 0.68618940391 0.691390059851284 2920 3747.09090909091 3972 0.1 2810 0.763693804170852 -0.811146364123331 -1 0.407824804462136 2916 4048 4100 4259 4649 3814 3384 3972 2810 4333 2933 4452 M10902 GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any neuron projection extension that is involved in neuron projection guidance. 15/17 Gene Ontology BP GO:1902284 0.0585026582200643 0.0850931130659453 3265 3432.72727272727 3974 0.00546535162290194 1127 1.85047522636126 1.83296125891155 1 6.75955013206581 3265 4241 1127 4055 2980 3974 3754 4045 4492 1759 4068 4453 M12223 GO_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 76/79 Gene Ontology BP GO:0032204 0.381237865862605 0.433819064876804 4580 3554.27272727273 3974 0.0427009857779749 516 0.944283767795723 -0.79263335092894 -1 1.16027056732442 4577 3690 4020 4076 2401 4643 3766 3267 516 4167 3974 4454 M11804 GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE.html The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. 15/17 Gene Ontology BP GO:0048846 0.0585026582200643 0.0850931130659453 3270 3433.45454545455 3975 0.00546535162290194 1128 1.85047522636126 1.83296125891155 1 6.75955013206581 3266 4242 1128 4056 2981 3975 3755 4042 4493 1761 4069 4455 M12433 GO_RNA_SURVEILLANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SURVEILLANCE.html The set of processes involved in identifying and degrading defective or aberrant RNAs. 14/14 Gene Ontology BP GO:0071025 0.68618940391 0.691390059851284 4440 3738 3976 0.1 1199 0.593198550542442 -0.593198550542442 -1 0.314397125638736 4437 1199 3823 3145 3976 3470 3500 4545 4268 4510 4245 4456 M16511 GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. 782/916 Gene Ontology BP GO:0006974 0.420911058352087 0.472294614853892 2885 3592.18181818182 3976 0.0531645120652134 2175 0.888387156716229 -0.89813390108614 -1 0.978866082483335 2885 4277 4627 4109 4640 2175 3976 3519 2695 4425 2186 4457 M14454 GO_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_POTENTIATION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. 43/63 Gene Ontology BP GO:0060291 0.222344312992218 0.267814674696554 3610 3578.09090909091 3977 0.0226017041258753 2065 1.10009280704796 1.1606955896079 1 2.14134341287745 3610 4061 2446 4002 4175 4102 3711 2065 3977 2819 4391 4458 M16204 GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. 60/68 Gene Ontology BP GO:0008156 0.00845478670256312 0.0181290887221319 2565 3275 3977 0.000771586824299509 866 0.762190418810461 0.737416076152379 1 4.52781604310343 2565 4039 3977 4253 866 2740 2119 2837 4102 4249 4278 4459 M10586 GO_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAPPING.html A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. 16/30 Gene Ontology BP GO:0016233 0.138253088429096 0.176728467159501 4470 3666.36363636364 3978 0.0134356214905906 1892 0.993080515465065 -1.46114318887848 -1 2.54494996167123 4466 4223 3536 4261 1892 4084 2752 4383 2850 3905 3978 4460 M13712 GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT.html A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. 117/132 Gene Ontology BP GO:0044774 0.68618940391 0.691390059851284 3910 3779.90909090909 3979 0.1 2327 1.01579013575299 -0.997909468304065 -1 0.545968093488503 3909 3996 3882 4236 3089 4585 3979 4232 2327 4253 3091 4461 M12761 GO_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_MODIFICATION.html The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure. 524/725 Gene Ontology BP GO:0016568 0.6513215599 0.691390059851284 3755 3995.36363636364 3981 0.1 3045 0.870489437952084 0.789889261764168 1 0.466346481519495 3755 4279 4388 3891 3720 3981 3602 4611 3045 4385 4292 4462 M11419 GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. 27/39 Gene Ontology BP GO:0043508 0.68618940391 0.691390059851284 4165 3868.36363636364 3986 0.1 2946 1.34412749237741 -1.00062978656366 -1 0.725889800677421 4164 4464 2946 4378 3591 3054 3986 4162 3943 3340 4524 4463 M14886 GO_MACROMOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. 939/1194 Gene Ontology BP GO:0009057 0.43753298404381 0.487626580779844 4250 3587.63636363636 3986 0.0559180248198637 1848 0.894263813318096 -0.850493468084566 -1 0.942991698942984 4250 2938 4521 2902 2542 3986 4163 4106 1848 4409 3799 4464 M14382 GO_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE.html Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. 168/350 Gene Ontology BP GO:0051321 0.68618940391 0.691390059851284 3840 3985.63636363636 3987 0.1 3174 0.97138061625616 -1.19684876844968 -1 0.521632645809156 3836 4303 3927 3412 4291 3987 4545 4603 3174 4228 3536 4465 M12020 GO_HISTONE_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MONOUBIQUITINATION.html The modification of histones by addition of a single ubiquitin group. 25/26 Gene Ontology BP GO:0010390 0.138389084814759 0.176853724702849 4435 3535.18181818182 3988 0.0134497765446342 1451 0.577859008167662 -0.639931873185042 -1 1.47580295128273 4434 3468 3988 3160 1893 4128 4358 4367 1451 4138 3502 4466 M14805 GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of DNA biosynthetic process. 108/119 Gene Ontology BP GO:2000278 0.68618940391 0.691390059851284 4100 3925.54545454545 3989 0.1 3259 0.985687156517475 1.17144468775986 1 0.529472317707128 4100 4331 3864 4482 3277 4297 3259 3807 3350 3989 4425 4467 M16085 GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. 23/36 Gene Ontology BP GO:0048486 0.146367438847018 0.185369540815235 3365 3604.63636363636 3990 0.0142837717159035 1376 1.43373340740568 1.44718930988642 1 3.57731000434715 3365 4158 1376 4151 3990 3939 3466 4511 4020 2612 4063 4468 M12811 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. 5/15 Gene Ontology BP GO:0048934 0.193407491720283 0.236760078656795 3655 3711.45454545455 3991 0.021264325647393 2104 0.827666116233386 -0.415484054182183 -1 1.75988591535255 3655 3269 4389 3155 2104 4066 3991 4409 4457 3157 4174 4469 M14140 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 5/15 Gene Ontology BP GO:0048935 0.193407491720283 0.236760078656795 3160 3720.54545454545 3992 0.021264325647393 2105 0.827666116233386 -0.415484054182183 -1 1.75988591535255 3656 3270 4475 3156 2105 4067 3992 4412 4458 3160 4175 4470 M15787 GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. 60/77 Gene Ontology BP GO:0000245 0.68618940391 0.691390059851284 4630 3905.81818181818 3993 0.1 2143 0.619213059063211 -0.690948171361085 -1 0.328652508677868 4626 3725 4109 3658 3250 4598 4579 3967 2143 4316 3993 4471 M13145 GO_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other. 121/132 Gene Ontology BP GO:0007062 0.247440933509061 0.295291783436178 3065 3513.54545454545 3994 0.0255121750952047 1255 0.937375432900814 -1.03753471473401 -1 1.68709544577099 3064 3994 4121 3383 2168 4181 4604 4036 1255 4266 3577 4472 M15329 GO_NUCLEOSIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSPORT.html The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/20 Gene Ontology BP GO:0015858 0.179641691441013 0.221658125238673 4545 3771 3994 0.0178402241379404 1946 1.34951082739011 -1.05311888348396 -1 3.00829170346064 4544 3559 2940 3722 4253 4293 4411 1946 4450 3369 3994 4473 M12781 GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 469/577 Gene Ontology BP GO:0009896 0.00577426225782821 0.0134540021460564 3845 3172.36363636364 3995 0.000526315789473684 212 0.916811953147859 1.00201521815325 1 5.85451181146227 3841 607 4103 212 4199 2997 4550 4535 1610 3995 4247 4474 M13204 GO_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an mRNA molecule. 86/117 Gene Ontology BP GO:0031124 0.68618940391 0.691390059851284 2225 3834.72727272727 3995 0.1 2221 0.662233808809225 0.643779395429357 1 0.352226940836387 2221 4351 4171 4483 4208 3995 3759 3721 3256 4375 3642 4475 M16252 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. 118/208 Gene Ontology BP GO:1902106 0.311938433261185 0.364411129792692 3930 3548.09090909091 3995 0.0334176836297766 1931 1.1193311586911 1.19058777080881 1 1.66709729653783 3929 3995 2033 4047 4051 4517 4174 2256 3446 1931 4650 4476 M10920 GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. 18/30 Gene Ontology BP GO:0044065 0.129170031808727 0.166397607421375 3940 3660.90909090909 3997 0.0124947870084959 1855 0.762197939878481 0.780371007066942 1 2.01896150494484 3937 4180 2848 4148 1855 4161 3826 2891 4011 3997 4416 4477 M16056 GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. 107/124 Gene Ontology BP GO:0048524 0.17564221207608 0.217357237444149 4390 3682.63636363636 3997 0.0174058851261671 2016 0.712042762788735 -0.722448199103839 -1 1.602944972202 4386 3997 4146 4466 2016 3265 4423 3317 3168 4349 2976 4478 M14381 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. 476/602 Gene Ontology BP GO:0022613 0.68618940391 0.691390059851284 1745 3690.45454545455 3999 0.1 1744 0.660917566679241 -0.746849986752407 -1 0.351505668869239 1744 4625 4215 4649 2979 3290 2733 3696 3999 4575 4090 4479 M15540 GO_CELL_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between cells. 94/122 Gene Ontology BP GO:0007043 0.68618940391 0.691390059851284 4315 3871.18181818182 3999 0.1 2336 0.941278093200511 -0.975397939323565 -1 0.505137120004393 4313 3999 3114 4136 4331 2336 4417 4581 3981 3557 3818 4480 M11747 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion. 7/14 Gene Ontology BP GO:2000484 0.0170477993661079 0.0313227439754325 4520 2816.63636363636 4001 0.00171800114615736 126 1.39556982570024 -1.52542681804564 -1 7.16616142812113 4516 553 4322 1134 1100 4001 4270 4053 126 2592 4316 4481 M16419 GO_RRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. 19/20 Gene Ontology BP GO:0031167 0.837979132550566 0.841778260742181 3960 3868.90909090909 4001 0.152493936780415 3005 0.560101717392276 -0.652698160071214 -1 0.132580537653956 3959 4544 4001 4471 3233 3047 3027 4099 4536 4636 3005 4482 M14653 GO_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ORGANELLE.html A process in which a protein is transported to, or maintained in, a location within an organelle. 637/807 Gene Ontology BP GO:0033365 0.6513215599 0.691390059851284 3695 4093.27272727273 4008 0.1 3692 0.844716869915695 -0.794364567100826 -1 0.452223676586721 3692 3956 4508 3894 4008 4234 3716 4505 3909 4433 4171 4483 M12156 GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication. 10/13 Gene Ontology BP GO:2000105 0.0064106301026061 0.0145861427224578 4500 3686.27272727273 4009 0.000584489704179656 800 0.462666481966081 0.4790281217624 1 2.89367565494956 4497 3595 3480 4009 800 3674 2727 4394 4397 4500 4476 4484 M12514 GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM.html Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. 408/924 Gene Ontology BP GO:0098542 6.14132411298211e-07 1.15630658568946e-05 4010 3316.81818181818 4009 5.58302347940013e-08 188 1.32637454687162 -1.25933537936352 -1 22.3773374427823 4009 4284 188 4498 4318 3088 4483 4267 3419 562 3369 4485 M15735 GO_COLLECTING_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLECTING_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. 18/27 Gene Ontology BP GO:0072044 0.68618940391 0.691390059851284 4205 3756.45454545455 4011 0.1 2681 1.20586966751236 1.29399424405593 1 0.650127529403483 4201 3857 2681 4011 4160 3734 4107 4131 3268 3151 4020 4486 M14315 GO_NON_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_RECOMBINATIONAL_REPAIR.html A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. 63/88 Gene Ontology BP GO:0000726 0.0649941249697074 0.0927946190500302 3250 3339.09090909091 4012 0.00609069119457618 1548 0.814558201907023 -0.879835597894213 -1 2.86471569517122 3246 4040 4071 4454 1548 2397 4012 4090 2767 4265 1840 4487 M15677 GO_GANGLION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLION_DEVELOPMENT.html The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. 19/27 Gene Ontology BP GO:0061548 0.420045109431624 0.47163848797909 3430 3652.72727272727 4012 0.0483212256500595 1878 1.35372862355729 1.45328267230989 1 1.49998041579795 3427 4188 1878 4012 3881 4096 4226 2471 4497 3242 4262 4488 M13093 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. 33/45 Gene Ontology BP GO:1904037 0.03754272396171 0.059255866551505 4200 3216.90909090909 4013 0.00347264748560191 1025 1.38361455711182 -1.21124369567588 -1 5.79493818158427 4198 4098 1025 3932 1466 4155 4485 2818 4140 1056 4013 4489 M13570 GO_TRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. 23/23 Gene Ontology BP GO:0030488 0.628884966583231 0.674550887393216 3325 3739.72727272727 4013 0.0861720998423434 2409 0.51983298789623 -0.51983298789623 -1 0.293226264624062 3325 4504 4013 4600 3113 2969 2409 2923 4399 4550 4332 4490 M13951 GO_INTERSTRAND_CROSS_LINK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTRAND_CROSS_LINK_REPAIR.html Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. 45/49 Gene Ontology BP GO:0036297 0.0437789988172641 0.0668319165015518 3020 3663.72727272727 4014 0.00406138652191884 1406 0.781720482172717 -0.833136993743972 -1 3.12975715683583 3019 4401 3957 4247 1406 3257 4200 4652 4014 4229 2919 4491 M14052 GO_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G2_M_PHASE_TRANSITION.html The cell cycle process by which a cell in G2 phase commits to M phase. 186/243 Gene Ontology BP GO:0044839 0.453388951254376 0.502769015773739 2365 3558.36363636364 4015 0.0534303350748251 2032 0.917306523050259 0.826187190578411 1 0.925912145742851 2362 4646 3949 4559 4459 2480 2032 4015 2394 4161 4085 4492 M15991 GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of autophagosome assembly. 41/43 Gene Ontology BP GO:2000785 0.68618940391 0.691390059851284 4410 3710.36363636364 4015 0.1 934 0.650104031144035 -0.578796591198911 -1 0.345580087344662 4408 934 4015 3806 3559 3520 2833 4432 4385 4286 4636 4493 M11505 GO_HISTONE_H2A_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_UBIQUITINATION.html The modification of histone H2A by addition of one or more ubiquitin groups. 20/20 Gene Ontology BP GO:0033522 0.329865167632992 0.382472620233319 4435 3756.63636363636 4016 0.0357346458333668 2325 0.421991850094212 -0.399166523655405 -1 0.591548091131237 4433 3840 4016 4398 2325 2835 3255 3670 4034 4480 4037 4494 M15461 GO_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECOMBINATIONAL_REPAIR.html A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. 76/92 Gene Ontology BP GO:0000725 0.68618940391 0.691390059851284 3855 3995.18181818182 4018 0.1 2949 0.73110018035757 -0.771767512335916 -1 0.389964209797402 3852 4012 4084 4025 4018 4422 4645 3924 2949 4362 3654 4495 M15653 GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE.html The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. 42/47 Gene Ontology BP GO:0042769 0.68618940391 0.691390059851284 2955 3872.63636363636 4019 0.1 2504 0.564532587184141 -0.568286280317819 -1 0.298688803202736 2953 4406 4019 4455 3555 2504 3802 4236 4441 4613 3615 4496 M11547 GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 625/771 Gene Ontology BP GO:0010638 0.6513215599 0.691390059851284 4275 3901 4020 0.1 2694 1.00265849121761 -1.01611545763312 -1 0.538772238812407 4273 3955 4309 3192 4488 4020 4132 4260 2694 3950 3638 4497 M10443 GO_LYSOSOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_TRANSPORT.html The directed movement of substances into, out of or within a lysosome. 93/101 Gene Ontology BP GO:0007041 0.127779455867832 0.164817665351166 4210 3609.54545454545 4021 0.0123515375345459 1846 0.80706874020746 0.81124954874628 1 2.14987880389286 4210 2585 4021 2213 1846 4610 4227 4306 3475 4220 3992 4498 M12489 GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS.html The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. 36/42 Gene Ontology BP GO:0006904 0.167560013534705 0.208799341986337 2775 3428.90909090909 4022 0.0165339833945994 1597 0.780234407061417 -0.851243525197454 -1 1.80401450265903 2772 4083 3819 4359 1988 4022 4031 2718 4198 4131 1597 4499 M13659 GO_TRNA_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_TRANSPORT.html The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 35/40 Gene Ontology BP GO:0051031 0.68618940391 0.691390059851284 4635 3956.45454545455 4023 0.1 2751 0.668848315380046 -0.647058111900683 -1 0.355851546110273 4634 3764 4023 3841 4181 3935 4372 3330 2751 4552 4138 4500 M13217 GO_SPERM_EGG_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_EGG_RECOGNITION.html The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. 36/76 Gene Ontology BP GO:0035036 0.68618940391 0.691390059851284 4630 4038.27272727273 4024 0.1 3211 1.22879306227052 -1.34935938869119 -1 0.662689049548059 4627 4432 3211 4592 3781 4024 3863 3743 4166 3710 4272 4501 M10686 GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE.html Any process in which a protein is transported to, or maintained at, the kinetochore. 12/13 Gene Ontology BP GO:0034501 0.68618940391 0.691390059851284 3500 3928.18181818182 4027 0.1 3187 0.922635242804285 0.922635242804285 1 0.494921244769722 3497 4246 3666 4060 3187 3969 3581 4408 4118 4451 4027 4502 M13301 GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 19/33 Gene Ontology BP GO:0010644 0.114132182282812 0.149762279797497 1690 3379.09090909091 4027 0.010956582710231 1051 0.801028497725392 0.589821743154271 1 2.24764138893236 1690 4173 2713 4153 4357 4035 1051 3930 4216 4027 2825 4503 M14810 GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. 76/107 Gene Ontology BP GO:0048024 0.68618940391 0.691390059851284 2500 3753.36363636364 4027 0.1 2499 0.693793998352811 0.53699317238019 1 0.369521236070612 2499 4027 4076 3683 2914 3354 3105 4515 4303 4330 4481 4504 M13463 GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 21/39 Gene Ontology BP GO:0086012 0.0284437116112945 0.0474027901602269 1655 3266.81818181818 4028 0.00261984149816626 971 0.947040868090051 -1.03787129228598 -1 4.27692914920328 1652 4184 971 4555 4297 4028 3134 1397 4589 4077 3051 4505 M10835 GO_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_LOCALIZATION.html Any process in which is the spindle is transported to, and/or maintained in, a specific location. 49/67 Gene Ontology BP GO:0051653 0.0644326059124514 0.0921909333673544 4310 3763.45454545455 4034 0.0060364429474425 1544 0.898938471987837 -1.00478193037962 -1 3.17128867153828 4307 4385 3501 4405 1544 4034 3804 3416 4319 4042 3641 4506 M14366 GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS.html A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. 32/34 Gene Ontology BP GO:0034067 0.68618940391 0.691390059851284 3790 3715.90909090909 4036 0.1 1114 0.671439579626493 -0.609605595407527 -1 0.35727150237657 3789 3436 4036 3798 4123 4118 3730 4158 1114 4223 4350 4507 M11295 GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 22/29 Gene Ontology BP GO:0010832 0.560626150178203 0.60919978439495 4300 3718.90909090909 4037 0.0720375938704403 2668 1.29161948120657 1.18252658831075 1 0.939833736473006 4300 3823 2668 4238 2672 4542 4384 2972 4037 2981 4291 4508 M12097 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 29/35 Gene Ontology BP GO:0050650 0.00828735162292736 0.0178358219710828 4040 3428.18181818182 4037 0.000756248684635195 861 1.40939979640326 -1.24479859075133 -1 8.41576766089681 4037 4449 1402 3899 861 3594 4345 4437 4428 1817 4441 4509 M13298 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING.html Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. 26/30 Gene Ontology BP GO:0006297 0.68618940391 0.691390059851284 3185 3937.54545454545 4039 0.1 3185 0.74844565225092 -0.816006162495975 -1 0.39946914992098 3185 4151 3878 4081 3756 3885 4039 4071 4419 4157 3691 4510 M13363 GO_POSITIVE_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HAIR_CYCLE.html Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 10/13 Gene Ontology BP GO:0042635 0.536801165520927 0.586185360987766 4385 3716.45454545455 4039 0.0675721783741405 1849 1.69912545546799 1.39345206142158 1 1.33687328606079 4385 4584 1849 4353 4258 4039 4301 3373 3644 2318 3777 4511 M11368 GO_POSTREPLICATION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTREPLICATION_REPAIR.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. 60/72 Gene Ontology BP GO:0006301 0.501202395198483 0.551062085269032 3220 3657.81818181818 4041 0.0612745806052145 2293 0.842081604205028 -0.861836124188678 -1 0.734429395388292 3219 4041 3939 4048 4309 2472 4131 3494 4205 4085 2293 4512 M11360 GO_PROTEIN_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEALKYLATION.html The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 28/32 Gene Ontology BP GO:0008214 0.68618940391 0.691390059851284 2465 3882 4045 0.1 2463 0.556679825034088 -0.547241428702783 -1 0.294385660889867 2463 4146 4045 4451 4311 3585 3478 3817 4259 4474 3673 4513 M14983 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. 16/18 Gene Ontology BP GO:1902285 0.141398057356711 0.17981010136124 3300 3593.09090909091 4045 0.0137634833422967 1809 1.4243927399176 1.42125080178669 1 3.61833590295709 3299 4210 1897 4221 4045 4576 2839 1809 4474 3505 4649 4514 M12130 GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS.html Any process that modulates the frequency, rate or extent of removal of superoxide radicals. 9/10 Gene Ontology BP GO:2000121 0.109169021975058 0.144124449092773 2655 3460.09090909091 4046 0.0114934961407002 1721 1.06922507295661 1.27781802747814 1 3.06467628425516 2652 4600 4346 4426 4439 4046 1790 1721 4617 2876 2548 4515 M13741 GO_PROTEIN_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMETHYLATION.html The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 28/32 Gene Ontology BP GO:0006482 0.68618940391 0.691390059851284 2465 3896.18181818182 4046 0.1 2464 0.556679825034088 -0.547241428702783 -1 0.294385660889867 2464 4147 4046 4452 4312 3586 3479 3883 4260 4555 3674 4516 M10262 GO_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 176/205 Gene Ontology BP GO:0010212 0.68618940391 0.691390059851284 4565 3891.45454545455 4050 0.1 2336 1.0505499715764 -0.928084497469775 -1 0.565015725068571 4562 2966 3221 4364 4050 4611 4044 4401 2336 3855 4396 4517 M14406 GO_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_GENE_SILENCING.html The inactivation of gene expression by a posttranscriptional mechanism. 50/58 Gene Ontology BP GO:0016441 0.68618940391 0.691390059851284 4065 3865.63636363636 4053 0.1 1436 1.03384854305933 -0.824590824634768 -1 0.555863706662322 4064 4053 3990 4284 3693 4045 3898 4429 1436 4072 4558 4518 M10177 GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity. 31/37 Gene Ontology BP GO:1904030 0.00573833708615173 0.0134540021460564 4055 3687.81818181818 4054 0.000523032679758636 763 0.983211320035707 0.750144412726243 1 6.27929235161732 4054 4444 3338 4536 763 4364 3874 4107 4343 3177 3566 4519 M10037 GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that activates or increases the frequency, rate or extent of viral transcription. 47/51 Gene Ontology BP GO:0050434 0.0744153062726441 0.104042794497179 4090 3863.18181818182 4057 0.00700531484027048 1611 0.591097237028303 -0.545328297042036 -1 1.97548334370821 4358 4057 4087 3679 1611 3920 4325 4048 4006 4318 4086 4520 M10897 GO_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 45/54 Gene Ontology BP GO:0090311 0.68618940391 0.691390059851284 4060 3988.81818181818 4057 0.1 2848 0.730054004470741 -0.692393287147745 -1 0.389390928238723 4057 4383 3818 4601 4310 4478 2848 3158 4389 3973 3862 4521 M15172 GO_ESTROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 9/23 Gene Ontology BP GO:0006703 0.0287470080075478 0.047681498883924 4060 3664.18181818182 4058 0.00291257985997543 1288 0.325293571007156 -0.357373881484698 -1 1.45922575779767 3350 4257 4539 4051 1288 2660 4058 4506 4058 4598 2941 4522 M12906 GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 46/75 Gene Ontology BP GO:0086065 0.0820257533697869 0.113186782452437 3180 3632.54545454545 4060 0.00775035017635606 1213 1.15131596554167 -1.32185976566057 -1 3.71387050551292 3177 4060 1213 4366 4564 2036 4390 3746 4379 3543 4484 4523 M15765 GO_VESICLE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING.html The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. 54/63 Gene Ontology BP GO:0048278 0.379289016318047 0.43202736668981 3230 3606 4060 0.0424272771051711 2018 0.865532360510975 -1.03855091283484 -1 1.06793584687362 3227 4368 3846 4383 2709 4283 4060 2435 4222 4115 2018 4524 M11487 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. 97/102 Gene Ontology BP GO:0000070 0.68618940391 0.691390059851284 3715 3945 4065 0.1 2442 0.828521634790512 -0.848585813271774 -1 0.443349041114212 3711 4344 4153 3883 3595 4459 4065 4621 2442 4355 3767 4525 M11870 GO_GABAERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABAERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. 6/21 Gene Ontology BP GO:0097154 0.12291333175445 0.159752997947893 3995 3723.18181818182 4066 0.0130293206167777 1874 1.2595105762753 1.2595105762753 1 3.41944541440225 3994 4266 4330 4361 1874 4480 3772 2397 4112 3303 4066 4526 M13842 GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. 22/25 Gene Ontology BP GO:0090083 0.0555948313608624 0.0817091321109676 3640 3886.09090909091 4066 0.00518650348123832 1492 0.755303338387139 0.843160764207254 1 2.79822698721768 3636 4519 3219 4609 1492 3847 4615 4066 4634 4095 4015 4527 M13932 GO_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. 398/504 Gene Ontology BP GO:0051052 0.68618940391 0.691390059851284 3395 3890 4068 0.1 3049 0.907821302662475 0.874845893549602 1 0.486803528808581 3394 4626 4159 4635 3049 4068 3303 3568 3065 4321 4602 4528 M14372 GO_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that modulates the frequency, rate or extent of the transcription of the viral genome. 70/86 Gene Ontology BP GO:0046782 0.0387510950883882 0.0607919236164094 4300 3861.09090909091 4070 0.00358645302211776 1354 0.688489845233383 -0.743979900959324 -1 2.85205526725571 4299 4028 4070 4439 1354 4460 3809 4224 3636 4248 3905 4529 M12032 GO_NEGATIVE_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_AGING.html Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 22/27 Gene Ontology BP GO:0090344 0.91410065408 0.915477904312148 4405 3999 4071 0.2 3076 0.66900872641767 -0.506611707348012 -1 0.0770603137746015 4405 3822 3389 3866 4071 3787 3076 4405 4572 4093 4503 4530 M11875 GO_MEMBRANE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DOCKING.html The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. 69/78 Gene Ontology BP GO:0022406 0.387456836196962 0.439287684898749 4075 3724.90909090909 4072 0.0435796884700256 2416 0.839668718051207 -0.962565374434438 -1 1.01492733846258 4072 4353 3997 4422 2416 4086 3315 3099 4228 4244 2742 4531 M14955 GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM.html A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). 18/21 Gene Ontology BP GO:0034975 0.550529562135741 0.599488427947017 3850 3995.45454545455 4075 0.0701189962651115 2690 0.803116497618436 0.670881433680547 1 0.599509630263648 3847 4222 3651 4291 3733 4075 4283 2690 4635 4003 4520 4532 M15934 GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION.html The directed movement of the mitochondrion to a specific location. 20/23 Gene Ontology BP GO:0051654 0.0743816036848493 0.104042794497179 3190 3793.27272727273 4077 0.00700202788241642 1610 1.05321238800274 -1.16723466499832 -1 3.5282366612132 4077 4511 3188 4435 1610 4623 3973 3189 4257 3702 4161 4533 M15661 GO_MATURATION_OF_5_8S_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA.html Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. 28/29 Gene Ontology BP GO:0000460 0.68618940391 0.691390059851284 3410 4057.09090909091 4078 0.1 3407 0.4801993354748 0.382679174444499 1 0.252476021397058 3407 3458 4078 4054 4633 4369 4095 3666 3852 4614 4402 4534 M11336 GO_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION.html The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 37/52 Gene Ontology BP GO:0006306 0.329539448994722 0.382190193462722 4225 3865.18181818182 4079 0.0356920479161099 2323 1.09481865146078 0.787690268400479 1 1.552918148873 4221 4437 3975 4463 2323 3660 4090 3691 3433 4145 4079 4535 M15564 GO_RRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. 18/20 Gene Ontology BP GO:0016075 0.68618940391 0.691390059851284 4655 3879.18181818182 4079 0.1 2158 0.687596232972703 -0.629200787068822 -1 0.366124995876046 4520 3520 3727 2641 4651 4079 4651 4086 2158 4610 4028 4536 M13865 GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. 15/15 Gene Ontology BP GO:0051988 0.68618940391 0.691390059851284 4080 4027.09090909091 4080 0.1 3291 0.851707059157029 0.851707059157029 1 0.456054147766743 3291 4206 3712 4080 4077 4229 3840 4093 4016 4561 4193 4537 M16784 GO_DNA_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_ALKYLATION.html The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. 37/52 Gene Ontology BP GO:0006305 0.329539448994722 0.382190193462722 4225 3870.36363636364 4080 0.0356920479161099 2324 1.09481865146078 0.787690268400479 1 1.552918148873 4222 4438 3976 4464 2324 3661 4091 3736 3434 4148 4080 4538 M14333 GO_HISTONE_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_UBIQUITINATION.html The modification of histones by addition of ubiquitin groups. 37/40 Gene Ontology BP GO:0016574 0.346687629880309 0.398995187195913 4625 3955.09090909091 4082 0.0379607138299098 2344 0.562656640085528 -0.621028297566408 -1 0.756953166180449 4622 3414 4082 3652 2344 4554 4418 4618 3705 4261 3836 4539 M13743 GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 461/528 Gene Ontology BP GO:0042176 0.68618940391 0.691390059851284 4220 3283.09090909091 4084 0.1 609 0.89047775690898 -0.804401670714829 -1 0.477299644167616 4216 609 4160 1151 4013 3254 4577 4354 1391 4305 4084 4540 M12199 GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. 5/26 Gene Ontology BP GO:0002829 0.91720355661869 0.91838780911271 4095 4099.18181818182 4094 0.220526835228862 3371 0.568865900787895 0.568865900787895 1 0.0612486166572373 4094 3951 4354 4371 3371 3965 3550 3877 4596 4501 4461 4541 M14534 GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. 99/110 Gene Ontology BP GO:0031023 0.68618940391 0.691390059851284 4605 3883.36363636364 4094 0.1 1291 0.842563713433561 -0.82373223874577 -1 0.451043793815862 4603 3998 4111 4064 4402 4227 3720 4094 1291 4299 3908 4542 M15875 GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE.html Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 11/17 Gene Ontology BP GO:0010984 0.0241277109912548 0.0413703738400163 3495 3735.36363636364 4094 0.00221785986593327 1186 0.658704167014507 -0.851030761377607 -1 3.10465622410556 3491 4566 3375 4214 1186 3830 2915 4521 4278 4619 4094 4543 M14097 GO_VIRION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRION_ASSEMBLY.html A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. 42/47 Gene Ontology BP GO:0019068 0.0993196617029455 0.133079111773474 3680 3891 4098 0.00946446098874121 1742 0.672904826822561 0.680459622498103 1 2.00443298666319 3677 4073 4035 4098 1742 4602 3126 4298 4283 4294 4573 4544 M13041 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. 20/21 Gene Ontology BP GO:1904357 0.25862073532316 0.307513278666735 4320 3872.90909090909 4100 0.0268372115945669 2192 0.534514143745797 -0.519211581489334 -1 0.925253605681136 4319 3844 3953 4251 2192 4159 3910 3072 4272 4530 4100 4545 M15254 GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN.html The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. 49/58 Gene Ontology BP GO:0051220 0.029201128681531 0.0482503024698735 4195 3903.90909090909 4105 0.00269055284453182 1256 0.757250459854778 -0.715580609216637 -1 3.39775497036576 4191 4056 3806 4105 1256 4457 4442 4276 4229 4044 4081 4546 M11928 GO_HISTONE_H3_K9_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K9_MODIFICATION.html The modification of histone H3 at a lysine in position 9 of the histone. 20/20 Gene Ontology BP GO:0061647 0.0513792563759972 0.0763306768574441 4110 3969.90909090909 4107 0.00478363074237422 1465 0.773631782920787 -0.835115189575871 -1 2.94460521230836 4107 4524 3743 4575 1465 4603 3517 4492 4055 4047 4541 4547 M14172 GO_ZINC_II_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_II_ION_TRANSPORT.html The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/27 Gene Ontology BP GO:0006829 0.68618940391 0.691390059851284 4320 3857.90909090909 4108 0.1 2572 0.88181048325545 -0.587827355070001 -1 0.472550167323285 4317 3836 3298 4157 4108 4346 4621 3148 2572 3700 4334 4548 M13590 GO_SULFUR_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSPORT.html The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 22/34 Gene Ontology BP GO:0072348 0.661996517012531 0.691390059851284 4410 3427 4109 0.0939030838286895 1288 1.28315451717454 -1.41665868893953 -1 0.692477940681738 4409 1719 1997 2972 4606 4591 4653 4109 1288 2984 4369 4549 M12389 GO_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE.html Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. 894/1049 Gene Ontology BP GO:0000278 0.6513215599 0.691390059851284 3130 3782.72727272727 4111 0.1 2334 0.860137021552146 -0.878879827173292 -1 0.460673583219538 3129 4613 4366 4626 4195 3361 4111 3372 2334 4440 3063 4550 M12877 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS.html The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. 111/130 Gene Ontology BP GO:0090501 0.669772994992334 0.691390059851284 4310 3767.45454545455 4113 0.0958183486385224 1840 0.917952019797567 -0.911528042047501 -1 0.492354940748828 4308 4326 4113 4602 2852 3236 3836 4319 1840 4334 3676 4551 M13097 GO_PROTEIN_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_STABILIZATION.html Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. 150/182 Gene Ontology BP GO:0050821 0.136563897642884 0.17466515000889 4025 3866.45454545455 4117 0.0132599727385913 1886 0.97769363903472 0.907618075735025 1 2.52240159251509 4021 4308 3688 3678 1886 4504 4238 3289 4157 4117 4645 4552 M16875 GO_TRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. 58/58 Gene Ontology BP GO:0006400 0.0731112174045345 0.102628026343498 4120 3793.45454545455 4118 0.00687820847801101 1599 0.759227417117536 -0.79562349932392 -1 2.5558520963311 3701 4374 4118 4605 1599 4120 3959 4582 3306 4356 3008 4553 M13583 GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 21/25 Gene Ontology BP GO:0090201 0.236737802465134 0.283463971917208 4175 3850.90909090909 4121 0.0242602953776653 2155 0.718641751875306 -0.6880251114098 -1 1.33454908997178 4172 4178 3555 4265 2155 4544 3476 4121 3847 3745 4302 4554 M10638 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. 221/330 Gene Ontology BP GO:0050688 0.68618940391 0.691390059851284 4440 3941.36363636364 4124 0.1 3012 1.08487899052052 -1.02850456681013 -1 0.5838272783991 4439 4639 3012 4124 4442 3184 4517 4576 3595 3521 3306 4555 M11012 GO_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PHASE_TRANSITION.html The cell cycle process by which a cell commits to entering the next cell cycle phase. 311/387 Gene Ontology BP GO:0044770 0.531211749274522 0.580626795718664 2545 3728 4128 0.0665548735460418 2204 0.895534268462787 0.864759467829128 1 0.712233551015491 2544 4634 4128 4625 3923 2448 2204 4342 3548 4354 4258 4556 M11316 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. 13/16 Gene Ontology BP GO:0055022 0.69717933800813 0.702159190422474 3905 3979.09090909091 4134 0.102912003013971 2890 0.582013416451284 -0.646033509452592 -1 0.294910985103381 3902 4581 3136 4461 2890 3668 4364 4134 4652 4471 3511 4557 M14123 GO_RNA_SECONDARY_STRUCTURE_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SECONDARY_STRUCTURE_UNWINDING.html The process in which a secondary structure of RNA are broken or 'melted'. 40/45 Gene Ontology BP GO:0010501 0.563852635589711 0.612133997526581 2310 3729.45454545455 4142 0.07265915980022 2308 0.961592784338432 -1.12825192601143 -1 0.690108196471841 2308 4453 4142 4297 2679 3332 3237 4282 3807 4274 4213 4558 M14518 GO_DNA_METHYLATION_OR_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_OR_DEMETHYLATION.html The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. 47/65 Gene Ontology BP GO:0044728 0.670445527055208 0.691390059851284 4140 4101.72727272727 4143 0.0959859068752544 2853 1.11792897897877 0.899137855442541 1 0.601937950931512 4136 4407 3995 4477 2853 4391 4021 4580 3626 4143 4490 4559 M16411 GO_NEGATIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_GROWTH.html Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 13/16 Gene Ontology BP GO:0061117 0.69717933800813 0.702159190422474 3905 3995.90909090909 4146 0.102912003013971 2891 0.582013416451284 -0.646033509452592 -1 0.294910985103381 3903 4582 3137 4462 2891 3669 4365 4146 4653 4635 3512 4560 M10919 GO_CHROMOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION.html Any process in which a chromosome is transported to, or maintained in, a specific location. 65/72 Gene Ontology BP GO:0050000 0.68618940391 0.691390059851284 3470 3998 4149 0.1 3090 0.728647158918275 -0.807347050928571 -1 0.388620007573 3469 4037 4149 4288 4644 4258 4220 4127 3090 4368 3328 4561 M14530 GO_STRAND_DISPLACEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRAND_DISPLACEMENT.html The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. 25/27 Gene Ontology BP GO:0000732 0.312662764142699 0.364890855669922 4150 4032 4157 0.033510230932051 2259 0.677848605674238 0.677848605674238 1 1.00403713009693 4150 4157 3955 4430 4118 4451 3398 2259 4294 4580 4560 4562 M14800 GO_HISTONE_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). 14/14 Gene Ontology BP GO:0071044 0.0702422245442256 0.0993425747125476 3945 3980.81818181818 4158 0.00659914602431014 1581 0.538391103603391 -0.666809401927574 -1 1.83534105330303 3945 3898 3895 4200 1581 4521 4158 4440 3965 4586 4600 4563 M14040 GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. 26/27 Gene Ontology BP GO:0016242 0.91410065408 0.915477904312148 3835 4139 4159 0.2 3186 0.729417611939147 -0.889404954787164 -1 0.084981363977757 3831 4467 3667 4570 4081 4009 3186 4510 4561 4159 4488 4564 M15974 GO_MACROMOLECULE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_METHYLATION.html The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. 188/226 Gene Ontology BP GO:0043414 0.378887899368341 0.431781875033282 4460 3739 4165 0.0423710386826715 2142 0.939283177617227 -1.09091289017387 -1 1.16063446688497 4457 4648 4165 4632 2393 4270 3625 3237 3218 4342 2142 4565 M11699 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT.html Any process that modulates the frequency, rate or extent of cellular response to heat. 92/95 Gene Ontology BP GO:1900034 0.91410065408 0.915477904312148 4120 4220 4166 0.2 3653 0.72818450468466 -0.688031185110846 -1 0.0848196741140168 4024 4350 4117 4640 4120 3889 4166 3653 4509 4365 4587 4566 M15857 GO_2_OXOGLUTARATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_OXOGLUTARATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. 19/25 Gene Ontology BP GO:0006103 0.0111883456935549 0.022556053948055 4340 3760.81818181818 4167 0.00102233215613242 935 0.829688318736147 -1.0025877242291 -1 4.66057104849924 4338 4183 3748 4215 935 4379 4167 4442 3077 4030 3855 4567 M16901 GO_FLUID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLUID_TRANSPORT.html The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/31 Gene Ontology BP GO:0042044 0.637409428666442 0.68237516426903 4080 3795.45454545455 4169 0.0881005470961374 1962 1.12834628305566 1.12738287069829 1 0.629635308221277 4079 4169 1962 4321 3619 4216 4179 3985 4414 2364 4442 4568 M12286 GO_PEPTIDYL_LYSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_MODIFICATION.html The modification of peptidyl-lysine. 329/381 Gene Ontology BP GO:0018205 0.653191401644791 0.691390059851284 3135 3868.09090909091 4170 0.0917822467845215 2444 0.886130758366097 0.7564959498033 1 0.474917583816567 3134 4632 4170 4628 3469 3170 2444 4336 3651 4383 4532 4569 M16823 GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION.html A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. 27/30 Gene Ontology BP GO:0034629 0.0801224997855466 0.110823421968534 3660 3728.81818181818 4175 0.00756350345226743 914 1.09754997924991 -1.17871935355346 -1 3.57432451079768 3659 4480 3403 4433 4346 4630 3532 3050 4395 4175 914 4570 M11432 GO_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 47/50 Gene Ontology BP GO:0044088 0.68618940391 0.691390059851284 4270 3927.72727272727 4176 0.1 2923 0.661392641301421 0.732189255675 1 0.351765999396181 4267 3052 4059 4554 2923 3570 3432 4176 4394 4319 4459 4571 M15919 GO_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION.html The process in which a methyl group is covalently attached to a molecule. 249/308 Gene Ontology BP GO:0032259 0.31553312098982 0.367871614123186 4645 3800 4179 0.0338778486107286 2297 0.953937422411632 -1.07474136870566 -1 1.40580228529917 4643 4638 4179 4629 2297 4522 3673 3664 2856 4359 2340 4572 M13579 GO_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR.html A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). 122/133 Gene Ontology BP GO:0006289 0.40277978766778 0.454445769160567 2050 3513.90909090909 4180 0.0457798335353359 1785 0.611767673703811 -0.617021337887577 -1 0.705748286142156 2050 4321 4180 4488 4513 1785 2304 3282 4353 4407 2970 4573 M15582 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. 17/19 Gene Ontology BP GO:0097296 0.000381307557926879 0.00200025261221394 4240 3624.45454545455 4180 3.46703329827643e-05 264 0.831785973464714 -0.684959210444045 -1 7.66459982681283 4238 4531 3455 4414 264 4180 4261 2867 4332 3971 3356 4574 M12563 GO_RNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. 114/121 Gene Ontology BP GO:0009451 0.268627981289701 0.317723944316467 3675 3806.45454545455 4181 0.0280387741997026 2216 0.797774244950743 -0.841773208665522 -1 1.34752002144945 3671 4338 4181 4490 2216 3436 4497 4424 3183 4393 3042 4575 M13872 GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 220/242 Gene Ontology BP GO:0061136 0.68618940391 0.691390059851284 3890 3594.90909090909 4181 0.1 1354 0.881086522985 -0.83216906323525 -1 0.472153452891715 3886 1967 4138 1948 4505 4321 4181 4487 1354 4320 4437 4576 M10604 GO_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION.html The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. 528/718 Gene Ontology BP GO:0051301 0.6513215599 0.691390059851284 4230 3922.18181818182 4182 0.1 2188 0.869733244809258 -0.903414321332742 -1 0.465932104177177 4228 3622 4251 4182 4470 3879 3586 4331 2188 4382 4025 4577 M12388 GO_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MEMBRANE.html The process of directing proteins towards a membrane, usually using signals contained within the protein. 190/285 Gene Ontology BP GO:0006612 0.0627231994852686 0.090077483705233 600 2981.63636363636 4182 0.00587147954234921 597 0.760146221209381 0.79688341651614 1 2.70618503156715 597 4306 4182 4495 4192 957 769 2236 4239 4422 2403 4578 M12786 GO_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FISSION.html The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 14/15 Gene Ontology BP GO:0000266 0.611192251952342 0.657240015792523 4215 3931.90909090909 4182 0.0822948398217499 2775 0.541762314575239 -0.637602458475909 -1 0.326959237164613 4182 4211 3744 3634 4213 3923 4525 2775 4305 4520 3219 4579 M15084 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 25/35 Gene Ontology BP GO:1902236 0.0180799198018015 0.0328104004827544 4190 3629.63636363636 4186 0.00165729413853886 1088 0.964567463812791 -0.926898797841538 -1 4.88324245520163 4186 4145 2938 2708 1088 4300 4280 4402 4519 2766 4594 4580 M16541 GO_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION.html The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. 217/248 Gene Ontology BP GO:0006260 0.68618940391 0.691390059851284 2870 3918.54545454545 4186 0.1 2870 0.821071401996293 -0.855892837229115 -1 0.439266476105248 2870 4642 4186 4619 4273 3289 3837 4206 3100 4386 3696 4581 M12195 GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. 20/31 Gene Ontology BP GO:0070193 0.98022673257 0.98022673257 4475 4145.09090909091 4189 0.3 3193 0.833641677864449 0.586470098384385 1 0.0140581531938857 4475 4189 3193 4272 4151 3996 4603 3637 4611 4049 4420 4582 M13854 GO_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_RECOMBINATION.html Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. 191/230 Gene Ontology BP GO:0006310 0.68618940391 0.691390059851284 3515 4016.18181818182 4189 0.1 3165 0.75195564760661 -0.732505964718767 -1 0.401392550788653 3515 4299 4189 4470 4267 3645 4140 4452 3165 4408 3628 4583 M15487 GO_RNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an RNA molecule. 109/144 Gene Ontology BP GO:0031123 0.68618940391 0.691390059851284 4190 4061.36363636364 4190 0.1 2672 0.651878520069207 0.643779395429357 1 0.34655246855674 2672 4333 4190 4487 4616 4442 4188 3834 3507 4397 4009 4584 M11258 GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 34/46 Gene Ontology BP GO:1900739 0.0768871060196281 0.107048385490523 4280 3876.27272727273 4191 0.00724668251957206 1627 0.760650016140308 -0.737241279559096 -1 2.51303291776386 4280 4420 3342 4191 1627 3833 4289 4466 4017 4236 3938 4585 M13747 GO_MRNA_CLEAVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE.html Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. 21/22 Gene Ontology BP GO:0006379 0.00850858493835267 0.018177431459208 4370 3690.45454545455 4191 0.000776515591574401 868 0.695662914461612 -0.639228287162368 -1 4.12892586956927 4370 4494 3898 4539 868 2846 3051 4191 4210 4556 3572 4586 M11661 GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 34/46 Gene Ontology BP GO:1900740 0.0768871060196281 0.107048385490523 4285 3875.63636363636 4192 0.00724668251957206 1628 0.760650016140308 -0.737241279559096 -1 2.51303291776386 4281 4421 3343 4192 1628 3834 4290 4449 4018 4237 3939 4587 M16451 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 29/48 Gene Ontology BP GO:0032786 0.68618940391 0.691390059851284 4360 3913.36363636364 4192 0.1 1732 0.589635645299438 0.498983508126827 1 0.312444731307296 4356 3445 4012 3599 4429 4508 4300 4575 1732 4192 3899 4588 M12055 GO_NUCLEAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSPORT.html The directed movement of substances into, out of, or within the nucleus. 384/481 Gene Ontology BP GO:0051169 0.68618940391 0.691390059851284 3320 4007.27272727273 4199 0.1 2974 0.859071630959657 -0.842312725315775 -1 0.460089772421417 3318 4630 4199 4638 4445 4153 3265 3548 2974 4394 4516 4589 M13565 GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. 30/52 Gene Ontology BP GO:0002726 0.146627906120994 0.185648883586663 3270 3868 4199 0.0143111182099435 1916 0.701464830822071 -0.687432425654149 -1 1.74321146515929 3267 4457 3643 4427 1916 3637 4523 4486 4588 4199 3405 4590 M14184 GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR.html Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. 78/91 Gene Ontology BP GO:0000731 0.68618940391 0.691390059851284 4205 4151.90909090909 4204 0.1 3624 0.8711061475362 -0.916927132404192 -1 0.466684424915138 4204 4352 4056 4472 4193 3624 4593 3903 4251 4290 3733 4591 M11119 GO_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING.html The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. 458/612 Gene Ontology BP GO:0006605 0.68618940391 0.691390059851284 3165 4120.36363636364 4206 0.1 3162 0.794156676293062 -0.735866522041577 -1 0.424517793692646 3162 4623 4206 4643 3825 4198 3246 4481 3944 4434 4562 4592 M15994 GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 166/233 Gene Ontology BP GO:0043902 0.0834545446251575 0.114919797614933 4480 3840.81818181818 4208 0.00789084942662355 1661 0.753259726875613 -0.742781071252713 -1 2.40915442626062 3195 4652 4007 4478 1661 4476 3531 3349 4208 4364 4328 4593 M12231 GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that modulates the frequency, rate, or extent of immunoglobulin production. 55/86 Gene Ontology BP GO:0002637 0.68618940391 0.691390059851284 4455 4003.36363636364 4210 0.1 3184 0.800303724882511 -0.870040989807464 -1 0.427886242192559 4455 3359 3550 4050 3184 4548 4210 4528 4300 3611 4242 4594 M16281 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. 81/94 Gene Ontology BP GO:1901989 0.68618940391 0.691390059851284 4590 4090.72727272727 4213 0.1 3322 0.84851345639951 -0.810650971594325 -1 0.454304123139258 4589 3333 4039 4213 4510 4490 4499 3862 3322 4256 3885 4595 M13539 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. 223/271 Gene Ontology BP GO:0071826 0.68618940391 0.691390059851284 2705 3890.81818181818 4214 0.1 2704 0.725143060805173 -0.868431498682151 -1 0.386699838265588 2704 4645 4214 4491 3884 3431 3133 4526 2903 4415 4453 4596 M13502 GO_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SUMOYLATION.html The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. 132/158 Gene Ontology BP GO:0016925 0.68618940391 0.691390059851284 3725 3937.81818181818 4215 0.1 2709 0.734678834703898 -0.679162966761553 -1 0.391925234293822 3724 4312 4119 4273 3143 3259 2709 4616 4215 4371 4575 4597 M11638 GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. 8/15 Gene Ontology BP GO:0045628 0.0118560525631481 0.0235350736247133 3985 3916.90909090909 4219 0.00119197863449424 992 0.730903067632628 -0.694416570387007 -1 4.05828839484641 3981 4263 4318 3646 992 4553 4219 3974 4642 4481 4017 4598 M11750 GO_RNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLATION.html Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. 54/57 Gene Ontology BP GO:0001510 0.68618940391 0.691390059851284 4225 4002.09090909091 4224 0.1 2912 0.668702225744338 -0.708941615950538 -1 0.355771492177545 4224 4388 4157 4633 2912 4280 3688 3044 4306 4343 4048 4599 M10125 GO_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION.html A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. 924/1244 Gene Ontology BP GO:0051276 0.6513215599 0.691390059851284 3345 3793.81818181818 4226 0.1 2835 0.871035093171627 -0.960846617917559 -1 0.466645488673741 3342 4276 4226 4301 4576 3375 4351 3169 2842 4439 2835 4600 M12933 GO_ONE_CARBON_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_COMPOUND_TRANSPORT.html The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/11 Gene Ontology BP GO:0019755 0.8926258176 0.895512705755239 3960 3973.72727272727 4227 0.2 2752 1.76021367452208 -1.11459678042491 -1 0.277773194401907 3957 4256 4395 4307 4227 3614 3707 3705 4464 2752 4327 4601 M13892 GO_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BIOSYNTHETIC_PROCESS.html The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 121/137 Gene Ontology BP GO:0071897 0.68618940391 0.691390059851284 4540 4118.36363636364 4227 0.1 3465 0.759162686137139 -0.816041384770921 -1 0.405341850647555 4539 4320 4155 4481 3465 4433 3737 3539 4227 4372 4034 4602 M13328 GO_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_NUCLEAR_DIVISION.html A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. 419/475 Gene Ontology BP GO:0007067 0.68618940391 0.691390059851284 3930 4036.90909090909 4228 0.1 1661 0.861093172917012 -0.946999732219773 -1 0.461197533304494 3927 4624 4212 4569 4636 4538 4228 4143 1661 4405 3463 4603 M16759 GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA.html The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. 25/29 Gene Ontology BP GO:0070918 0.0903947008184115 0.122984369271365 4635 3873 4230 0.00857615053824769 1697 1.06517926982442 -0.707967568033868 -1 3.30391443646186 4631 4513 3809 4615 1697 4386 4317 4230 2358 3891 4156 4604 M15862 GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 13/16 Gene Ontology BP GO:0032785 0.68618940391 0.691390059851284 4635 4182.72727272727 4238 0.1 3400 0.457390805423037 0.397835702170108 1 0.239977444605271 4633 4228 3810 4045 3400 4421 4486 3624 4238 4618 4507 4605 M13970 GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of T cell cytokine production. 34/76 Gene Ontology BP GO:0002724 0.417342445295825 0.46894334652535 3245 3883.45454545455 4239 0.0479189003252515 2462 0.701464830822071 -0.687432425654149 -1 0.778079836342498 3241 4445 3638 4448 2462 3197 4647 4490 4548 4239 3363 4606 M11015 GO_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_PROCESSING.html Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. 435/527 Gene Ontology BP GO:0006397 0.68618940391 0.691390059851284 4205 4123.63636363636 4241 0.1 3010 0.765686138048247 0.71056539260977 1 0.408916559954708 3294 4627 4204 4303 4489 4204 3899 4241 3010 4442 4647 4607 M14464 GO_DSRNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DSRNA_FRAGMENTATION.html Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. 25/29 Gene Ontology BP GO:0031050 0.0903947008184115 0.122984369271365 4630 3873.18181818182 4242 0.00857615053824769 1696 1.06517926982442 -0.707967568033868 -1 3.30391443646186 4630 4512 3808 4614 1696 4385 4316 4242 2357 3890 4155 4608 M14528 GO_MITOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_RECOMBINATION.html The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. 41/43 Gene Ontology BP GO:0006312 0.68618940391 0.691390059851284 4335 4143.45454545455 4242 0.1 3403 0.639591560389254 -0.60613994781784 -1 0.339819482750597 4333 4078 4041 4409 4242 4477 3403 3679 4074 4579 4263 4609 M16023 GO_RNA_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_LOCALIZATION.html A process in which RNA is transported to, or maintained in, a specific location. 190/248 Gene Ontology BP GO:0006403 0.68618940391 0.691390059851284 3870 3966.09090909091 4247 0.1 1160 0.828895828893365 -0.878466107064307 -1 0.443554091317752 3867 4300 4191 4290 4247 4573 4234 3960 1160 4377 4428 4610 M13802 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. 107/128 Gene Ontology BP GO:2001251 0.68618940391 0.691390059851284 4555 3934.90909090909 4251 0.1 2465 0.74408273789473 -0.783011883259216 -1 0.397078368051518 4553 3320 4158 3190 4356 4251 4508 4591 2465 4348 3544 4611 M11514 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION.html A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. 21/25 Gene Ontology BP GO:0000132 0.480542868276036 0.530478283769489 4260 4032.72727272727 4256 0.057804809516701 2551 0.895171151004603 -0.784029773455404 -1 0.832003899921085 4256 4505 3441 4343 2551 4648 3971 4288 4523 4075 3759 4612 M12503 GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 9/107 Gene Ontology BP GO:0048387 0.361370631172425 0.414050122345553 4370 3946.27272727273 4258 0.0438525113851542 2419 0.260150131080106 -0.268584417355743 -1 0.329945567033797 4369 4258 4372 4085 2419 4047 3352 2792 4624 4512 4579 4613 M16755 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 50/72 Gene Ontology BP GO:0032784 0.150147714009217 0.189692455412676 4470 3920.63636363636 4259 0.0146814093271755 1925 0.639239222956049 0.488533691751948 1 1.56717710301568 4468 3050 4032 4367 1925 3985 4396 4648 4418 4259 3579 4614 M15019 GO_NUCLEAR_ENVELOPE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. 92/100 Gene Ontology BP GO:0006998 0.68618940391 0.691390059851284 4625 3651.45454545455 4264 0.1 673 0.805268866397901 -0.78417657465828 -1 0.430607031404813 4623 3326 4133 1949 4293 4388 4264 3848 673 4310 4359 4615 M15686 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. 38/69 Gene Ontology BP GO:0002711 0.194930090008363 0.238247887787999 4395 3851.54545454545 4277 0.019518468329852 2060 0.806870033793186 -0.687432425654149 -1 1.70789367552689 4318 4422 3592 4449 2060 4392 3878 2578 4391 4010 4277 4616 M13429 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 202/268 Gene Ontology BP GO:0015931 0.68618940391 0.691390059851284 4165 4065.36363636364 4281 0.1 1911 0.859008693007483 -0.827818065589727 -1 0.460055283796917 4162 4293 4175 4281 4491 4438 4466 3878 1911 4350 4274 4617 M11992 GO_REGULATION_OF_CENTRIOLE_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTRIOLE_REPLICATION.html Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. 14/18 Gene Ontology BP GO:0046599 0.95219940076243 0.953223711649653 4560 4146.45454545455 4283 0.241512399379722 3183 0.557914672155332 -0.557914672155332 -1 0.0290227146243281 4451 4559 3893 4283 4135 3642 3183 4556 4625 4495 3789 4618 M16221 GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA.html The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. 28/60 Gene Ontology BP GO:0007339 0.113883937692568 0.149505537718432 4620 3884 4293 0.0109313898064702 1688 0.713570209225479 -0.75625898477041 -1 2.00289205844125 4618 4483 3713 4293 3327 4401 3929 1688 4632 4627 3013 4619 M14674 GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. 189/234 Gene Ontology BP GO:1901796 0.68618940391 0.691390059851284 3935 4216.45454545455 4294 0.1 3848 0.828318872510377 -0.788092940137091 -1 0.443237931808922 4629 4297 4116 4294 3935 4488 3956 4527 3848 4360 3931 4620 M12639 GO_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that modulates the frequency, rate or extent of receptor internalization. 42/56 Gene Ontology BP GO:0002090 0.68618940391 0.691390059851284 3950 4050.36363636364 4295 0.1 2666 1.19288509964948 1.09739773866579 1 0.643012269534739 3949 4405 2666 4256 4366 4595 3972 4381 4295 3086 4583 4621 M16096 GO_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING.html The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 384/464 Gene Ontology BP GO:0008380 0.68618940391 0.691390059851284 3675 4214.63636363636 4302 0.1 3209 0.742329736887172 0.691224982478744 1 0.396117761749431 3672 4286 4218 4302 4647 4441 4074 4579 3209 4437 4496 4622 M11490 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE.html The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 406/551 Gene Ontology BP GO:0072594 0.68618940391 0.691390059851284 4305 4218.36363636364 4304 0.1 3719 0.820280138048429 -0.806784553581841 -1 0.438832880727005 3750 4629 4208 4304 4305 4575 3719 4119 4028 4429 4336 4623 M10199 GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. 94/104 Gene Ontology BP GO:0006354 0.134051564403939 0.1720667390818 4640 3995.18181818182 4307 0.0129993073365149 1872 0.632659376399536 -0.653427378457068 -1 1.64254706264058 4636 4343 4184 4480 1872 3822 4388 4214 3303 4398 4307 4624 M15485 GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. 146/170 Gene Ontology BP GO:0051053 0.440303624943212 0.490127456186786 3925 4026.72727272727 4311 0.0513924205490505 2503 0.725364082114604 0.765971937253152 1 0.757365175423295 3923 4311 4156 4639 2503 4471 3701 3420 4352 4388 4430 4625 M14460 GO_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE.html The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. 1438/1842 Gene Ontology BP GO:0007049 0.6513215599 0.691390059851284 4530 4127.36363636364 4323 0.1 2565 0.886293580188126 -0.897620984102578 -1 0.475006806622307 4530 4611 4495 4568 4323 4264 3960 4115 2565 4441 3529 4626 M12744 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION.html Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. 130/173 Gene Ontology BP GO:0071166 0.68618940391 0.691390059851284 2765 4061.18181818182 4325 0.1 2762 0.609105098484121 -0.627570236522429 -1 0.323113566833769 2762 4325 4211 4641 4504 3799 3119 4597 3862 4424 4429 4627 M11963 GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 18/20 Gene Ontology BP GO:0051974 0.91410065408 0.915477904312148 4575 4155.18181818182 4326 0.2 3131 0.869341127505198 0.761714178173349 1 0.103328684605062 4555 4536 3472 4573 4326 4524 3131 4270 4575 4001 3744 4628 M15413 GO_NUCLEAR_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXPORT.html The directed movement of substances out of the nucleus. 177/222 Gene Ontology BP GO:0051168 0.68618940391 0.691390059851284 3150 4225 4328 0.1 3149 0.64701087228941 -0.650280118672064 -1 0.343885103784301 3149 4307 4216 4642 4555 3972 3643 4607 4328 4423 4633 4629 M10551 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION.html The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. 115/151 Gene Ontology BP GO:0006353 0.68618940391 0.691390059851284 4395 4218.45454545455 4336 0.1 3599 0.632202986767653 0.6489474048851 1 0.335770705622839 4394 4336 4198 4637 3654 3983 4204 4570 3599 4402 4426 4630 M10699 GO_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CONDENSATION.html The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. 30/40 Gene Ontology BP GO:0030261 0.68618940391 0.691390059851284 4460 4248.63636363636 4339 0.1 3875 0.554611718193395 -0.551542074929428 -1 0.293252383466756 3961 4462 4004 4458 4645 4456 4339 3994 4087 4454 3875 4631 M15791 GO_RRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. 27/28 Gene Ontology BP GO:0000154 0.68618940391 0.691390059851284 4470 4246.90909090909 4348 0.1 3510 0.649712931740935 -0.7104488174168 -1 0.345365773405457 4469 4479 4054 4441 4282 3510 4348 4457 4213 4617 3846 4632 M13371 GO_NCRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). 550/678 Gene Ontology BP GO:0034660 0.617701881976993 0.663933207863005 3205 4017.09090909091 4349 0.0916771992336501 2831 0.742065757450135 -0.777147598205535 -1 0.440622584892564 3205 4622 4424 4650 2831 4349 3399 3828 3735 4541 4604 4633 M13861 GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. 4/16 Gene Ontology BP GO:0002837 0.8926258176 0.895512705755239 4350 4211.09090909091 4350 0.2 3678 0.607942761840675 0.607942761840675 1 0.0889572919416998 4350 4269 4455 4379 3734 3925 3678 4063 4521 4560 4388 4634 M16192 GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of a response to tumor cell. 4/16 Gene Ontology BP GO:0002834 0.8926258176 0.895512705755239 4355 4228.36363636364 4351 0.2 3679 0.607942761840675 0.607942761840675 1 0.0889572919416998 4351 4270 4602 4380 3735 3926 3679 4032 4522 4626 4389 4635 M14820 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. 36/39 Gene Ontology BP GO:0006360 0.68618940391 0.691390059851284 4355 4194.81818181818 4355 0.1 2840 0.662080943945599 -0.626104178221439 -1 0.352143174226595 4355 4433 4081 4579 4653 3904 4646 4465 2840 4251 3936 4636 M14029 GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION.html The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. 77/108 Gene Ontology BP GO:0006369 0.68618940391 0.691390059851284 4235 4172.90909090909 4356 0.1 3258 0.584557851923862 0.617039753444292 1 0.309662211333697 4231 4356 4172 4486 3258 3869 4399 4589 3631 4384 4527 4637 M12532 GO_SECRETORY_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. 33/40 Gene Ontology BP GO:0033363 0.68618940391 0.691390059851284 4430 4219.72727272727 4367 0.1 3404 0.882259879966744 -1.09207968675155 -1 0.472796426915347 4486 4426 3404 4527 4367 4589 3760 4227 4430 4231 3970 4638 M15562 GO_PROTEIN_REFOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_REFOLDING.html The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. 26/28 Gene Ontology BP GO:0042026 0.0217477745643866 0.037885584068922 4600 3975.54545454545 4367 0.00199688928375025 1158 0.587291467489641 -0.531564823362371 -1 2.84364582049517 4598 4542 3695 4492 1158 4367 4363 3045 4650 4609 4212 4639 M13414 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS.html Splicing of RNA via a series of two transesterification reactions. 291/364 Gene Ontology BP GO:0000375 0.68618940391 0.691390059851284 4525 4323.27272727273 4370 0.1 3972 0.656726549514504 0.624593914149572 1 0.349209082909939 4143 4636 4213 4112 4523 4463 4521 4165 3972 4438 4370 4640 M10089 GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS.html A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. 24/26 Gene Ontology BP GO:0006278 0.0214719957067959 0.0375457331919283 4530 3909.63636363636 4373 0.00197131557652031 1156 0.670904797652069 -0.692623706236106 -1 3.25899336408756 4529 4473 3968 4373 1156 4402 2920 4593 4130 4443 4019 4641 M12565 GO_ORGANELLE_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FISSION.html The creation of two or more organelles by division of one organelle. 529/735 Gene Ontology BP GO:0048285 0.6513215599 0.691390059851284 3685 3996.81818181818 4375 0.1 2142 0.876235832762782 -0.96328213586588 -1 0.469495380490821 3682 4621 4375 4566 4377 4115 4459 3893 2142 4416 3319 4642 M13719 GO_MALE_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS_I.html A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. 19/129 Gene Ontology BP GO:0007141 0.98022673257 0.98022673257 4065 4155.72727272727 4387 0.3 3013 0.931314742631887 0.830318803206059 1 0.0169545595697641 4065 4529 3013 4416 4224 4387 4514 4634 4602 3234 4095 4643 M13850 GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. 8/14 Gene Ontology BP GO:0090192 0.377978364033237 0.430956463574283 2525 3624 4406 0.0463685855741619 2087 0.405403903076409 0.405403903076409 1 0.496032537342516 2523 4605 4454 4406 4583 2920 2558 2539 4631 4558 2087 4644 M12266 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. 8/13 Gene Ontology BP GO:0043371 0.969700924793035 0.970326538292901 3760 4193.90909090909 4415 0.295074960529715 3582 0.767389564878248 0.767389564878248 1 0.0236602805547135 3759 4604 4358 4562 3582 3738 3587 4443 4581 4504 4415 4645 M15668 GO_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_RESORPTION.html The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. 30/39 Gene Ontology BP GO:0045453 0.91410065408 0.915477904312148 4485 4108.81818181818 4415 0.2 2960 1.12069556258127 0.876754725209731 1 0.136287264817828 3900 4439 2960 4415 3994 4485 4537 3904 4483 3472 4608 4646 M13147 GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING.html Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. 9/19 Gene Ontology BP GO:0010738 0.955691294583124 0.95651357145521 4420 4295.36363636364 4419 0.267767660042779 3266 0.738601556777189 -0.738601556777189 -1 0.038096775428368 3989 4598 4410 4419 4285 4420 3266 4050 4633 4535 4644 4647 M14250 GO_DNA_REPLICATION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_CHECKPOINT.html A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. 13/15 Gene Ontology BP GO:0000076 0.91410065408 0.915477904312148 4575 4198.27272727273 4427 0.2 3456 0.273635389440053 -0.306173800204116 -1 0.0252174098018839 4552 4572 3801 4429 4427 3741 3655 3456 4556 4571 4421 4648 M16550 GO_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PROCESS.html The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. 1201/1538 Gene Ontology BP GO:0022402 0.6513215599 0.691390059851284 3625 3989 4436 0.1 2612 0.876661946679059 -0.894172174238632 -1 0.469728881619239 3623 4612 4634 4586 4562 3648 4553 3564 2612 4436 3049 4649 M13682 GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 4/19 Gene Ontology BP GO:0010919 0.87538825191498 0.878787817941835 3615 4169.90909090909 4444 0.18800024380071 2998 0.569858103705044 -0.569858103705044 -1 0.0986688462512593 4042 3612 4444 3613 4574 4290 2998 4628 4648 4554 4466 4650 M16317 GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS.html The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. 11/16 Gene Ontology BP GO:0071428 0.91410065408 0.915477904312148 3505 4121.36363636364 4452 0.2 3052 0.449778277853084 -0.488932657548836 -1 0.0483139567751333 3505 4589 3737 4557 4531 3539 3052 4240 4500 4633 4452 4651 M16594 GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process that decreases the concentration of calcium ions in the cytosol. 8/20 Gene Ontology BP GO:0051481 0.106408848679233 0.14093947421135 4455 4082.81818181818 4452 0.0111876409878103 1810 0.599701591196811 -0.423904113349636 -1 1.73411663090784 4452 4607 4639 4571 1810 3933 4156 4030 4600 4643 3470 4652 M14987 GO_PRE_MIRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MIRNA_PROCESSING.html Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. 11/13 Gene Ontology BP GO:0031054 0.98022673257 0.98022673257 4590 4321.63636363636 4517 0.3 3652 0.359570456763604 -0.359570456763604 -1 0 4517 4599 3869 4608 3652 4625 4033 4112 4587 4590 4346 4653 M11429 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION.html Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. 22/23 Gene Ontology BP GO:0010569 0.68618940391 0.691390059851284 4615 4254.72727272727 4550 0.1 3510 0.927771168358473 0.762620699034841 1 0.49773561990877 4612 4162 3510 4550 4577 4552 4004 4584 3536 4092 4623