Rank ID GeneSet BroadUrl Description PubMedID NumGenes Contributor Ontology GOID p.value p.adj vote.rank avg.rank med.rank min.pvalue min.rank avg.logfc avg.logfc.dir direction significance camera safe gage padog plage zscore gsva ssgsea globaltest ora fry 1 M11113 GO_FERRIC_IRON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERRIC_IRON_TRANSPORT.html The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 36/44 Gene Ontology BP GO:0015682 1.24284229099487e-08 1.89604759999972e-07 10 1133.18181818182 29 1.12985663456004e-09 6 1.5879056508439 -1.67273012261794 -1 11.4067715067069 10 1797 2751 3297 15 6 8 29 2435 2098 19 2 M16469 GO_TRIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 36/44 Gene Ontology BP GO:0072512 1.24284229099487e-08 1.89604759999972e-07 20 1135.90909090909 46 1.12985663456004e-09 7 1.5879056508439 -1.67273012261794 -1 11.4067715067069 11 1798 2752 3298 16 7 9 46 2436 2102 20 3 M11591 GO_IRON_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_TRANSPORT.html The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/73 Gene Ontology BP GO:0006826 1.76124904907299e-08 1.97691467186943e-07 35 1300.72727272727 78 1.60113551197544e-09 13 1.61418345921947 -1.6551443010984 -1 11.5658116104856 31 1738 2823 4354 72 13 34 78 3142 1946 77 4 M15608 GO_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_GUIDANCE.html The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. 211/347 Gene Ontology BP GO:0097485 4.17684385669185e-19 4.13507541812493e-17 25 328.636363636364 108 3.79713077881076e-20 15 2.84389452630314 3.15108562137811 1 50.1715272014756 25 1417 25 350 994 15 124 60 422 75 108 5 M14116 GO_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_MIGRATION.html The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. 45/59 Gene Ontology BP GO:0008347 7.56545892945201e-08 2.29330738099751e-07 115 491.727272727273 111 6.87769017237855e-09 20 2.7940297188085 3.04008086087823 1 19.9077964536802 111 425 864 202 1472 50 99 20 111 2004 51 6 M10048 GO_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. 90/162 Gene Ontology BP GO:0021510 4.34924067767834e-08 1.97691467186943e-07 90 369.181818181818 117 3.95385523969063e-09 40 2.64378104410123 2.74075497288893 1 19.0151363649958 88 109 486 919 835 40 78 117 695 645 49 7 M13107 GO_REGULATION_OF_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ORGANIZATION.html Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 124/183 Gene Ontology BP GO:0050807 3.73297053489804e-15 1.95083563496978e-13 90 303 117 3.39360957718004e-16 31 2.9845879007058 3.18910419199219 1 40.8258795680599 86 1579 58 41 363 31 181 54 675 117 148 8 M14206 GO_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTION_POTENTIAL.html A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. 71/148 Gene Ontology BP GO:0001508 2.60237946805147e-15 1.42457313704041e-13 1260 452.363636363636 123 2.36579951641043e-16 8 3.17656361384375 3.52158778148312 1 43.9272498197152 1256 118 55 8 123 742 1660 562 283 82 87 9 M16285 GO_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. 91/129 Gene Ontology BP GO:0001823 1.58092093330526e-11 4.08668061259411e-10 230 323.181818181818 138 1.43720084846966e-12 26 3.1211162941129 3.62632859163085 1 31.5116265825033 226 87 130 43 1145 92 872 341 455 138 26 10 M12483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration. 28/34 Gene Ontology BP GO:0014912 3.46523438658973e-08 1.97691467186943e-07 45 471.181818181818 141 3.15021312833716e-09 32 3.48859320314296 3.64656744024311 1 25.1275051405921 41 1858 725 204 575 141 32 86 109 1376 36 11 M13356 GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. 25/46 Gene Ontology BP GO:0086019 6.10852747696191e-11 1.47269317877222e-09 55 226.545454545455 142 5.55320679739227e-12 39 3.96356738401157 4.19821299902496 1 37.6662443717037 55 626 142 52 628 68 93 39 402 237 150 12 M14476 GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a cardiac muscle cell. 41/74 Gene Ontology BP GO:0086001 7.24718561058196e-14 2.98417297752547e-12 150 269.545454545455 144 6.58835055507471e-15 15 3.71415289448676 3.89921759669994 1 46.0847719396619 150 354 77 15 1520 39 92 175 280 144 119 13 M10489 GO_SYNAPSE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 204/264 Gene Ontology BP GO:0050808 3.00944351413904e-34 7.00147033564448e-31 5 252.363636363636 147 2.73585774012641e-35 1 3.02768217751074 3.30296470821869 1 98.4198547848856 28 1404 1 329 147 1 250 184 366 22 44 14 M12499 GO_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPROUTING_ANGIOGENESIS.html The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells. 69/83 Gene Ontology BP GO:0002040 3.29669024581396e-08 1.97691467186943e-07 70 542.727272727273 150 2.99699117746792e-09 30 2.92075660785849 2.97091800100475 1 21.0191046665807 66 230 240 138 2695 32 150 107 1982 300 30 15 M13718 GO_CARDIAC_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 139/191 Gene Ontology BP GO:0003231 6.31625586840894e-14 2.6477061761898e-12 135 394.909090909091 151 5.74205078946283e-15 5 2.93603896901613 3.43973598883281 1 36.5709575160073 131 1551 75 491 128 54 616 394 748 151 5 16 M13463 GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 21/39 Gene Ontology BP GO:0086012 1.02493535803527e-08 1.65018139132807e-07 10 446.090909090909 153 9.31759420736575e-10 4 4.1799634437907 4.35296647071776 1 30.4836215999633 8 724 248 66 2852 44 48 4 278 482 153 17 M14729 GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. 217/287 Gene Ontology BP GO:0001763 3.69583811904937e-19 3.73842060172537e-17 160 438.545454545455 159 3.35985283549942e-20 4 2.98210354765999 3.37702737437444 1 52.7562346112449 159 1434 24 53 931 4 326 957 769 136 31 18 M16051 GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE.html The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. 191/250 Gene Ontology BP GO:0048754 2.11272429149604e-17 1.61155838169362e-15 105 470.636363636364 161 1.92065844681457e-18 12 3.05493535068141 3.47056512098118 1 48.6583517611216 105 1474 35 56 1427 12 293 899 645 161 70 19 M10755 GO_TRANSITION_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_TRANSPORT.html The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 87/122 Gene Ontology BP GO:0000041 1.82205745311214e-08 1.97691467186943e-07 65 1433.54545454545 162 1.65641588018415e-09 21 1.5861342667474 -1.63917671755507 -1 11.3628706295681 63 2234 3125 4485 86 21 47 135 3019 2392 162 20 M14876 GO_UROGENITAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UROGENITAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. 343/437 Gene Ontology BP GO:0001655 6.33104151470224e-28 3.0221171592833e-25 170 383 167 5.75549228609296e-29 3 2.87661304508118 3.20674586698909 1 76.0090446925064 167 1329 3 11 722 9 420 757 631 35 129 21 M12378 GO_PALATE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALATE_DEVELOPMENT.html The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities. 118/155 Gene Ontology BP GO:0060021 5.02211405966247e-10 9.90165115237689e-09 25 399.181818181818 174 4.56555823709899e-11 14 2.80320825285498 3.12303412996706 1 24.1023728295555 14 21 174 994 468 24 128 511 1694 322 41 22 M15681 GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOPHILIC_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. 122/181 Gene Ontology BP GO:0007156 1.64228379584603e-17 1.29517737323247e-15 40 647.363636363636 178 1.49298526895094e-18 27 3.05674327179426 3.1615207892411 1 49.0003390700379 38 1581 34 1672 1005 27 584 178 1802 87 113 23 M10833 GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_GANGLION_CELL_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. 24/34 Gene Ontology BP GO:0031290 1.69153108026804e-08 1.97691467186943e-07 195 258.272727272727 179 1.53775553933986e-09 17 3.50372818995206 3.89672657704195 1 25.2370095076884 195 713 438 171 64 179 75 17 210 710 69 24 M13617 GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 35/45 Gene Ontology BP GO:0060314 1.81414391825905e-08 1.97691467186943e-07 185 772.363636363636 185 1.64922175747153e-09 83 2.18245548251042 2.38030210994511 1 15.6773624848819 182 573 1657 1764 83 185 136 146 2241 1415 114 25 M14097 GO_VIRION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRION_ASSEMBLY.html A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. 42/47 Gene Ontology BP GO:0019068 2.21030873531657e-08 1.97691467186943e-07 190 1526.18181818182 190 2.0093715977484e-09 42 1.03258064815678 -0.922075859748298 -1 7.35781007536202 190 2310 3756 2930 176 80 42 73 3588 3559 84 26 M13694 GO_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. 35/60 Gene Ontology BP GO:0086003 1.30367898243727e-09 2.40715012114309e-08 190 259.636363636364 192 1.18516271200891e-10 28 3.38124428701428 3.70280565181665 1 27.6879040171462 447 460 187 32 682 196 290 190 192 152 28 27 M16902 GO_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a synapse. 90/123 Gene Ontology BP GO:0007416 4.08321734857181e-15 2.0878253102093e-13 70 190.454545454545 195 3.71201577142891e-16 28 2.82304880930345 2.93024293249024 1 38.5202836091137 70 55 59 349 257 28 351 406 247 78 195 28 M12159 GO_MOTOR_NEURON_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTOR_NEURON_AXON_GUIDANCE.html The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. 42/55 Gene Ontology BP GO:0008045 2.32020624729248e-08 1.97691467186943e-07 315 300.909090909091 196 2.1092784288748e-09 128 3.08211321401863 3.33655999990843 1 22.1865488974356 314 406 255 166 196 160 161 148 1082 294 128 29 M10494 GO_ENDOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. 72/73 Gene Ontology BP GO:0007032 2.39775935618359e-08 1.97691467186943e-07 45 1081.18181818182 197 2.17978125665141e-09 5 1.20970182632196 -1.22092474212819 -1 8.63931383608177 40 197 3622 3856 229 5 44 45 1372 2473 10 30 M11036 GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 59/90 Gene Ontology BP GO:0051965 3.78678900701552e-09 6.52589972209007e-08 70 264.272727272727 200 3.44253546684872e-10 44 3.37042219324424 3.36482238728362 1 26.0234016500029 67 281 200 689 44 70 191 256 499 469 141 31 M16150 GO_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION.html Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. 74/127 Gene Ontology BP GO:0061337 6.25478227356e-11 1.5001805112822e-09 260 426.363636363636 206 5.68616570339803e-12 55 3.12376572341289 3.50537994954143 1 29.6344723522453 257 158 143 55 1659 94 234 542 1282 206 60 32 M15958 GO_TELENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. 288/430 Gene Ontology BP GO:0021537 6.06368132433614e-14 2.58846873414092e-12 100 492.363636363636 207 5.51243756757846e-15 22 2.5501143019628 3.06198341371386 1 31.7761041946044 98 1366 73 527 1204 22 392 82 1262 207 183 33 M16833 GO_CARDIAC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. 59/93 Gene Ontology BP GO:0055006 2.14490556080788e-08 1.97691467186943e-07 150 385.909090909091 209 1.9499141651998e-09 1 3.05064873597954 3.36147033194366 1 21.9588977077029 146 255 235 120 1894 113 209 47 826 399 1 34 M13089 GO_RENAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_TUBULE_DEVELOPMENT.html The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. 104/137 Gene Ontology BP GO:0061326 5.77220192891616e-16 3.62946696962796e-14 160 413 212 5.24745629901468e-17 37 3.38086443420022 3.90380289528581 1 48.9264785203315 156 37 46 392 1557 139 533 778 526 167 212 35 M15408 GO_OUTFLOW_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. 67/92 Gene Ontology BP GO:0003151 1.44719733268695e-09 2.65110597991827e-08 215 550.909090909091 213 1.31563393967177e-10 151 2.9892529262985 3.27554895208345 1 24.3296528178669 308 211 189 203 1621 151 230 1085 1685 164 213 36 M15599 GO_KIDNEY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MORPHOGENESIS.html Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 84/117 Gene Ontology BP GO:0060993 4.61811113924791e-10 9.21514796341147e-09 185 336 216 4.19828285474302e-11 38 2.98813010190965 3.27112423571746 1 25.800450824091 181 110 171 38 387 116 438 1135 565 216 339 37 M10039 GO_CARDIAC_CHAMBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_DEVELOPMENT.html The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. 193/257 Gene Ontology BP GO:0003205 1.28501197406842e-14 6.22829241181286e-13 100 380.272727272727 217 1.16819270369857e-15 4 2.76031514215337 3.23961334003763 1 36.2477089467865 96 1452 63 452 440 20 518 217 788 133 4 38 M11914 GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_DEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. 51/66 Gene Ontology BP GO:0016339 1.53391449559122e-08 1.97691467186943e-07 35 449.818181818182 225 1.39446773298744e-09 14 2.87046693705142 3.09052992995213 1 20.6552498021753 32 308 227 1676 225 14 133 265 1820 198 50 39 M12854 GO_REGULATION_OF_SYNAPSE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. 75/117 Gene Ontology BP GO:0051963 1.10128653191928e-12 3.55853210626418e-11 230 241 227 1.00116957447258e-13 39 3.28679822218843 3.49995604454474 1 36.9508025513761 225 155 101 39 109 227 645 236 408 230 276 40 M12997 GO_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_MORPHOGENESIS.html The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 271/374 Gene Ontology BP GO:0003007 1.1801382812634e-15 7.0399787470751e-14 240 513.272727272727 236 1.07285298296672e-16 32 2.56988207760598 3.02546775195185 1 36.3651321209281 236 1376 49 498 1072 42 596 125 1501 119 32 41 M10077 GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_JUNCTION_DEVELOPMENT.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. 57/69 Gene Ontology BP GO:0007528 9.24027031351783e-09 1.49288117252772e-07 140 332.090909090909 237 8.40024577484375e-10 82 2.88368402025346 3.16838608474461 1 21.1304454890427 82 237 213 496 410 137 411 715 183 629 140 42 M10790 GO_INDOLALKYLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLALKYLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. 8/18 Gene Ontology BP GO:0006586 2.14789391376662e-08 1.97691467186943e-07 245 812.272727272727 243 2.14789393452713e-09 13 4.33403852882383 -4.33403852882383 -1 31.2444549913464 243 1109 4262 949 209 131 13 108 46 1518 347 43 M11839 GO_AMEBOIDAL_TYPE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMEBOIDAL_TYPE_CELL_MIGRATION.html Cell migration that is accomplished by extension and retraction of a pseudopodium. 192/270 Gene Ontology BP GO:0001667 1.69670518667631e-13 6.47112232262693e-12 155 489.545454545455 243 1.54245926061494e-14 46 2.54943591563027 2.77994737123356 1 30.6727254367216 153 1456 84 464 611 46 370 243 1790 101 67 44 M10326 GO_NEURON_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_RECOGNITION.html The process in which a neuronal cell in a multicellular organism interprets its surroundings. 43/63 Gene Ontology BP GO:0008038 4.62642684146159e-08 1.97760774550163e-07 45 359.727272727273 247 4.20584267159246e-09 33 3.26085649383433 3.38468597561494 1 23.4792531270299 45 426 247 453 1610 36 33 50 536 382 139 45 M15217 GO_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. 395/509 Gene Ontology BP GO:0035239 4.44746680147205e-19 4.31126313067697e-17 285 401.090909090909 248 4.04315163770185e-20 2 2.52707897044948 2.8427645406192 1 44.5202973844137 282 1304 26 37 248 2 650 825 859 81 98 46 M11226 GO_MORPHOGENESIS_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIUM.html The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. 472/611 Gene Ontology BP GO:0002009 6.27934001689115e-25 1.46088845492973e-22 420 475.181818181818 252 5.7084909244465e-26 9 2.63071951606761 2.91875404720312 1 61.8809458983946 417 1272 9 20 252 30 635 982 1360 40 210 47 M14929 GO_HEART_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_PROCESS.html A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 101/167 Gene Ontology BP GO:0003015 2.18929628122527e-09 3.88808992234396e-08 450 356 254 1.99026934854902e-10 63 2.84730232087222 3.30597366266182 1 22.6578890275323 450 63 194 411 955 234 684 171 396 254 104 48 M10863 GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION_DURING_ACTION_POTENTIAL.html The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. 28/53 Gene Ontology BP GO:0086010 1.81130542616066e-08 1.97691467186943e-07 165 431.272727272727 256 1.64664131006682e-09 6 3.6277844036097 4.07429411916681 1 26.1345786521 163 574 286 61 2044 255 256 6 267 584 248 49 M14073 GO_ACTIN_MEDIATED_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MEDIATED_CELL_CONTRACTION.html The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. 79/134 Gene Ontology BP GO:0070252 1.44901774882036e-12 4.55559431436562e-11 105 378.909090909091 261 1.31728886256483e-13 105 3.09404671626849 3.41749712976922 1 34.4190123619173 542 105 105 361 319 637 1288 205 231 114 261 50 M16895 GO_RECEPTOR_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CLUSTERING.html The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. 49/64 Gene Ontology BP GO:0043113 3.44785575452529e-08 1.97691467186943e-07 475 280.727272727273 262 3.13441437141849e-09 66 2.49688944396474 2.89601811873857 1 17.9523490690718 188 283 408 474 563 112 66 181 262 475 76 51 M15544 GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH.html Any process that modulates the extent of cell growth. 126/153 Gene Ontology BP GO:0061387 2.34310860981699e-08 1.97691467186943e-07 175 494.909090909091 265 2.13009875888387e-09 18 2.50898121602149 2.86798636323054 1 18.0398352269949 265 18 522 952 203 172 574 233 1546 785 174 52 M15223 GO_SENSORY_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. 498/760 Gene Ontology BP GO:0007423 3.73797569317171e-23 6.95712036013119e-21 15 404.363636363636 269 3.39815972106519e-24 11 2.56650451016052 2.89762403479171 1 55.7203985303102 269 1255 12 368 497 11 651 227 1013 43 102 53 M13894 GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. 65/71 Gene Ontology BP GO:0034446 2.53993892429391e-08 1.97691467186943e-07 60 387.363636363636 273 2.30903541237997e-09 29 2.36034381129239 2.6392256173678 1 16.964416719072 58 246 666 727 273 29 330 143 1116 608 65 54 M16663 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY_PLANAR_CELL_POLARITY_PATHWAY.html Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway. 12/14 Gene Ontology BP GO:2000095 6.30397180171096e-08 2.13127647327128e-07 125 692.454545454545 275 5.730883620316e-09 7 2.52805052599914 2.52805052599914 1 18.0887193585518 122 1023 1537 1027 1269 82 7 110 275 2030 135 55 M11998 GO_FOREBRAIN_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_CELL_MIGRATION.html The orderly movement of a cell from one site to another at least one of which is located in the forebrain. 67/93 Gene Ontology BP GO:0021885 7.17124582266117e-08 2.23855118283271e-07 280 488.909090909091 276 6.51931459674473e-09 67 2.64091527040391 3.10048333256104 1 18.8405529502692 276 218 447 227 1398 195 182 67 785 690 893 56 M16618 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL_BY_SARCOPLASMIC_RETICULUM.html Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. 42/56 Gene Ontology BP GO:0010880 2.56071031826732e-08 1.97691467186943e-07 30 407.545454545455 277 2.32791849824813e-09 11 2.53312160510719 2.7649394617441 1 18.2144953084094 30 445 919 974 277 34 54 118 757 864 11 57 M13810 GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS.html Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. 47/71 Gene Ontology BP GO:0021952 3.00277884396902e-07 5.30811401713243e-07 265 738.363636363636 279 2.72979932165294e-08 100 2.59552325993928 2.94816742323181 1 17.4644140270526 279 416 871 264 2591 229 264 200 1984 924 100 58 M15276 GO_SENSORY_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_ORGAN_MORPHOGENESIS.html Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 265/407 Gene Ontology BP GO:0090596 1.10134689542986e-17 9.15101268649132e-16 225 495.363636363636 283 1.00122445039078e-18 31 2.72782947240471 3.13026232137168 1 44.1597271386656 223 1384 31 895 1060 69 549 283 796 71 88 59 M13421 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. 179/302 Gene Ontology BP GO:0021953 1.41351465931391e-11 3.72530388902941e-10 290 603.090909090909 286 1.28501332665727e-12 126 2.82176706641022 3.07019294880595 1 28.6009192909591 286 1508 126 190 1457 147 284 361 1631 195 449 60 M12187 GO_DIGESTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 176/259 Gene Ontology BP GO:0055123 3.5752034766374e-13 1.26025922551468e-11 60 572.090909090909 289 3.2501849787618e-14 57 2.65100205391588 3.11234402509242 1 31.0709756519563 289 1495 90 135 595 57 690 1171 1503 210 58 61 M15524 GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. 79/105 Gene Ontology BP GO:0007422 1.7287057759061e-08 1.97691467186943e-07 350 424.727272727273 289 1.57155071771804e-09 68 2.61921263198461 2.84974106712396 1 18.8373794595341 347 149 423 711 68 136 224 279 1207 839 289 62 M10469 GO_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_PRESSURE.html Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 166/298 Gene Ontology BP GO:0008217 7.64400792146944e-14 3.11996218057871e-12 295 576.545454545455 294 6.94909811042697e-15 78 2.99756996873843 3.50525585419148 1 37.1091562077357 294 1530 78 942 511 138 738 168 1614 243 86 63 M13993 GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. 171/268 Gene Ontology BP GO:0048738 3.14619104741947e-13 1.12609438028021e-11 90 485.818181818182 294 2.86017367947265e-14 48 2.77948790556142 3.24880555534854 1 32.7290121652696 132 1502 89 463 1380 88 453 294 741 154 48 64 M11503 GO_KIDNEY_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 142/192 Gene Ontology BP GO:0072073 4.68909076621739e-16 3.03032490766799e-14 295 475.545454545455 297 4.26280978747035e-17 17 3.08278245487563 3.47533490740624 1 44.8634726936809 292 1539 44 17 798 123 837 829 356 99 297 65 M16122 GO_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. 131/195 Gene Ontology BP GO:0055001 3.44815811686126e-12 1.00907419608525e-10 45 422.636363636364 299 3.13468919715151e-13 41 2.79702452914335 3.23590771611113 1 30.0614291255008 299 1565 112 381 683 248 509 41 578 190 43 66 M11359 GO_ARTERY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_DEVELOPMENT.html The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. 119/156 Gene Ontology BP GO:0060840 1.53857304744165e-11 3.99943038533297e-10 130 576.363636363636 304 1.39870277041128e-12 6 2.99312684249791 3.45152219928463 1 30.2450488623916 85 6 129 1303 2563 167 553 430 674 304 126 67 M14474 GO_DETECTION_OF_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_ABIOTIC_STIMULUS.html The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. 128/227 Gene Ontology BP GO:0009582 1.22502887295195e-11 3.25717676905452e-10 290 561 308 1.1136626117807e-12 75 2.87808795912742 3.09089271675781 1 29.3551852851876 288 1590 125 504 75 133 995 818 1199 308 136 68 M10047 GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. 9/18 Gene Ontology BP GO:0036150 1.18668294857614e-07 2.83888728006415e-07 30 1145.54545454545 312 1.18668301194588e-08 26 3.18086492972367 -3.18086492972367 -1 22.3615217279334 157 1084 4219 1479 2334 280 26 30 312 2422 258 69 M16725 GO_NEGATIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a lower concentration of a chemical. 56/67 Gene Ontology BP GO:0050919 2.74753171540645e-08 1.97691467186943e-07 65 343.272727272727 312 2.49775613610888e-09 19 2.83485812896697 3.34972814063571 1 20.3976136349609 62 312 356 572 338 41 141 19 1412 500 23 70 M15636 GO_CELLULAR_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 52/58 Gene Ontology BP GO:0071295 5.26682656496873e-15 2.66375478334777e-13 95 675.272727272727 313 4.78802414997158e-16 60 3.55445609566444 3.65043083123109 1 48.1237238437081 95 313 60 936 2734 213 294 1132 784 225 642 71 M11811 GO_FOREBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 391/610 Gene Ontology BP GO:0030900 1.51805930189816e-14 7.28198962034243e-13 205 528.909090909091 314 1.38005391081652e-15 64 2.49981744871009 2.94692589668045 1 32.6331155911041 204 1315 64 502 749 157 655 314 1355 197 306 72 M13343 GO_PALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. 202/287 Gene Ontology BP GO:0021543 3.97233597878023e-09 6.79532327546485e-08 105 518 314 3.61121453268428e-10 38 2.54376884007524 3.09463105874367 1 19.5647463265822 104 1450 202 576 1287 38 314 160 851 484 232 73 M14752 GO_MULTICELLULAR_ORGANISMAL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_SIGNALING.html The transfer of information occurring at the level of a multicellular organism. 94/189 Gene Ontology BP GO:0035637 1.62376589069221e-14 7.70957417284781e-13 415 397.909090909091 317 1.4761508097202e-15 25 3.15448711200204 3.46219070816598 1 41.1245600535269 412 66 65 25 496 287 757 753 1086 113 317 74 M16233 GO_REGULATION_OF_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. 29/51 Gene Ontology BP GO:0060306 6.55626151162987e-08 2.17413460714792e-07 1100 551.272727272727 320 5.96023791546752e-09 2 3.52295719825053 4.3575296421155 1 25.2191143822592 1100 561 320 79 1298 1106 1070 51 209 268 2 75 M10515 GO_NEURON_PROJECTION_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION.html Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. 72/84 Gene Ontology BP GO:1990138 1.34051166591136e-07 3.0411510392421e-07 145 622.636363636364 321 1.21864704326535e-08 33 2.36125694582788 2.79516386323495 1 16.4943557198746 145 195 702 735 1994 199 307 33 1497 721 321 76 M13430 GO_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_MIGRATION.html Any process that modulates the frequency, rate or extent of neuron migration. 68/79 Gene Ontology BP GO:2001222 2.46038611658768e-10 5.20371663658295e-09 190 418.454545454545 321 2.2367146516935e-11 53 3.02423461988464 3.36695100559997 1 26.9236054595808 53 190 162 567 1058 189 179 464 997 321 423 77 M16803 GO_NEUROPEPTIDE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROPEPTIDE_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. 30/105 Gene Ontology BP GO:0007218 8.68991435074212e-08 2.45384890956523e-07 220 516.909090909091 322 7.89992244908215e-09 46 4.25051027984734 4.63155230660313 1 30.2095509654332 220 613 292 46 1574 420 254 322 271 592 1082 78 M11371 GO_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). 479/666 Gene Ontology BP GO:0001501 3.57805347344909e-19 3.72841454247407e-17 305 597.545454545455 326 3.2527758849537e-20 22 2.56799635306437 2.88824449769293 1 45.4178070293558 302 1279 22 686 784 59 623 326 2207 127 158 79 M12477 GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 96/128 Gene Ontology BP GO:0071300 9.87089051223068e-10 1.86704282737436e-08 335 645.909090909091 327 8.97353683332686e-11 89 3.04409821753354 3.49921698956461 1 25.2783757864641 335 89 182 781 144 309 1354 1858 1456 270 327 80 M13151 GO_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MORPHOGENESIS.html Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 834/1215 Gene Ontology BP GO:0009887 7.14448501012601e-28 3.0221171592833e-25 330 826.636363636364 330 7.14448501012597e-29 8 2.62282270747658 2.93353745183855 1 69.293138204729 329 1198 4411 330 419 93 777 244 1099 8 185 81 M10832 GO_ADULT_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_BEHAVIOR.html Behavior in a fully developed and mature organism. 130/246 Gene Ontology BP GO:0030534 9.56450667424966e-12 2.60255260557214e-10 695 546.727272727273 334 8.69500606753751e-13 34 2.79546097522942 3.16570314341267 1 28.8031578174914 694 1574 123 34 564 305 1019 995 334 228 144 82 M10251 GO_REGULATION_OF_VESICLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_FUSION.html Any process that modulates the frequency, rate or extent of vesicle fusion. 56/71 Gene Ontology BP GO:0031338 5.90051798671154e-08 2.08467047776528e-07 200 1083.09090909091 336 5.36410740451509e-09 148 1.49248049961668 -1.44613786938984 -1 10.648142132575 197 322 3170 1890 1202 181 148 336 649 3514 305 83 M11013 GO_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of a tissue are generated and organized. 599/815 Gene Ontology BP GO:0048729 2.37758320447646e-21 3.2021727757844e-19 310 813.181818181818 337 2.37758320447647e-22 17 2.64307026008416 2.92952547314564 1 52.6423368521217 307 1227 4274 337 194 45 687 375 1264 17 218 84 M12034 GO_AORTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_DEVELOPMENT.html The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. 81/106 Gene Ontology BP GO:0035904 4.27386379682146e-12 1.23517318301927e-10 30 496.636363636364 337 3.8853307243907e-13 27 3.30916564152032 3.90959928718213 1 35.2728668513219 27 122 114 1294 2022 183 447 444 370 337 103 85 M11803 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE.html Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. 72/118 Gene Ontology BP GO:0050885 1.10773354081517e-07 2.71799508392894e-07 340 569.909090909091 340 1.00703054235567e-08 131 2.56726919141401 2.65588258613138 1 18.0784833122536 340 185 456 131 1827 256 430 798 1362 276 208 86 M13171 GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS.html The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. 48/73 Gene Ontology BP GO:0001658 4.3854871146822e-08 1.97691467186943e-07 245 367.272727272727 341 3.98680654736604e-09 64 3.40096694911267 3.87751692902274 1 24.4935133433331 245 373 341 64 841 162 312 602 450 508 142 87 M13433 GO_MESONEPHRIC_TUBULE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESONEPHRIC_TUBULE_MORPHOGENESIS.html The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. 57/83 Gene Ontology BP GO:0072171 1.83668368445783e-08 1.97691467186943e-07 375 444.545454545455 341 1.66971245435591e-09 48 3.28607160281217 3.80240365011748 1 23.6622247312171 371 295 231 48 796 250 744 1060 530 341 224 88 M16906 GO_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS.html The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. 123/161 Gene Ontology BP GO:0042476 3.62052171184765e-17 2.59173654234263e-15 100 573.545454545455 343 3.29138337440696e-18 38 3.25137085571755 3.50801461573416 1 51.0703462659005 99 1592 38 701 1370 95 343 425 1177 175 294 89 M12511 GO_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 95/116 Gene Ontology BP GO:0006029 1.24304741689684e-13 4.90937113493922e-12 260 373.818181818182 345 1.13004310626991e-14 26 3.15071176800317 3.3950134486947 1 38.3413422630779 26 74 80 345 970 257 408 497 682 256 517 90 M12906 GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_INVOLVED_IN_CARDIAC_CONDUCTION.html Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 46/75 Gene Ontology BP GO:0086065 2.95755437463473e-08 1.97691467186943e-07 345 576 345 2.68868583126764e-09 96 3.278265915998 3.69069385954342 1 23.6057491752673 161 360 237 1104 1450 96 271 345 1618 352 342 91 M13090 GO_CARDIAC_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_VENTRICLE_MORPHOGENESIS.html The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. 84/124 Gene Ontology BP GO:0003208 1.77813071756366e-13 6.67229212001911e-12 245 485.818181818182 345 1.61648247051255e-14 86 3.24210611144782 3.84965287381838 1 38.9905736690895 242 106 86 503 1565 345 942 544 628 215 168 92 M11566 GO_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_MOVEMENT.html Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. 97/158 Gene Ontology BP GO:0030048 2.46849676257659e-11 6.2764565225513e-10 980 593 346 2.2440879660039e-12 43 2.85874509214481 3.17343153547834 1 28.2782323870174 978 43 133 357 292 1310 1868 346 205 156 835 93 M11847 GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 100/124 Gene Ontology BP GO:0006023 1.03544285550882e-09 1.94270790592039e-08 70 461.181818181818 346 9.41311687269236e-11 67 2.75083011744613 2.91260762243836 1 22.7809428412072 68 67 184 346 1167 367 428 317 1139 240 750 94 M13631 GO_NEURON_PROJECTION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_MORPHOGENESIS.html The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. 454/670 Gene Ontology BP GO:0048812 5.81230184576688e-21 7.11701065482981e-19 240 472.454545454545 347 5.28391076887899e-22 21 2.47458664589731 2.82110651714564 1 48.3530965080669 237 1274 21 347 905 216 590 228 832 53 494 95 M15221 GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of embryonic development. 140/180 Gene Ontology BP GO:0045995 1.79038055242681e-08 1.97691467186943e-07 215 461.545454545455 351 1.62761869727009e-09 18 2.46309469763961 2.89034269430755 1 17.7078379668035 212 1559 331 582 77 166 480 351 660 641 18 96 M13349 GO_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOFIBRIL_ASSEMBLY.html Formation of myofibrils, the repeating units of striated muscle. 48/82 Gene Ontology BP GO:0030239 4.31802372289486e-09 7.33276072358752e-08 430 380.272727272727 356 3.92547611942728e-10 26 3.3631952194201 3.59860678720245 1 25.7835993444397 430 326 203 382 906 736 621 26 122 356 75 97 M14896 GO_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_DEVELOPMENT.html The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. 352/528 Gene Ontology BP GO:0001654 3.60430586951202e-15 1.90577672850448e-13 360 443.363636363636 356 3.27664169955638e-16 57 2.53006247437076 2.92148549366557 1 34.6189591033457 356 1331 57 420 306 77 898 434 758 115 125 98 M16247 GO_LIMBIC_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMBIC_SYSTEM_DEVELOPMENT.html The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. 112/180 Gene Ontology BP GO:0021761 1.99289106446862e-07 3.96787425030915e-07 210 659.454545454545 356 1.81171931363326e-08 61 2.5405517896048 2.97749524625157 1 17.4386545262893 210 61 587 787 2296 150 173 185 1486 963 356 99 M12887 GO_RESPONSE_TO_INSECTICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSECTICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. 10/22 Gene Ontology BP GO:0017085 9.76976732970955e-07 1.37753719348905e-06 115 798.090909090909 357 8.8816106075216e-08 22 3.69149588961044 3.69149588961044 1 23.236589053263 113 1058 1067 194 3651 357 22 106 66 1567 578 100 M15872 GO_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 143/188 Gene Ontology BP GO:0072006 3.40200588681788e-22 5.27651113045454e-20 95 510.818181818182 357 3.09273262437988e-23 16 3.31331924834379 3.61635903888649 1 68.8206753827486 94 1532 16 341 1503 108 388 712 482 86 357 101 M10162 GO_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCRETION.html The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. 34/63 Gene Ontology BP GO:0007588 2.17693020716307e-08 1.97691467186943e-07 1635 727.363636363636 358 1.97902748064009e-09 64 3.22758244141215 -2.88352646289444 -1 23.2390450692934 1635 455 238 358 164 1731 2142 307 64 266 641 102 M13393 GO_MUSCLE_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_MORPHOGENESIS.html The process in which the anatomical structures of muscle are generated and organized. 82/133 Gene Ontology BP GO:0048644 2.49391630984509e-11 6.30662640745065e-10 135 425.090909090909 358 2.26719664533942e-12 54 3.38940788161319 3.95588620910411 1 33.5408367975915 358 131 134 514 968 224 1023 559 397 314 54 103 M15728 GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_INDEPENDENT_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. 12/23 Gene Ontology BP GO:0016338 2.5249965907812e-09 4.45030649125187e-08 165 609.909090909091 360 2.29545144879928e-10 2 3.88623651535742 -4.59648194797338 -1 30.7206488056077 165 948 399 360 2931 444 129 2 118 1117 96 104 M14224 GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate. 70/74 Gene Ontology BP GO:0007044 2.82686348361157e-08 1.97691467186943e-07 140 650.272727272727 362 2.56987592721365e-09 121 2.65524996907832 2.98306222904747 1 19.0981161116405 139 203 343 923 362 400 1331 196 2719 416 121 105 M10365 GO_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_TISSUE_DEVELOPMENT.html The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. 290/442 Gene Ontology BP GO:0060537 1.72153172781829e-13 6.51242856060041e-12 315 680.181818181818 367 1.5650288434713e-14 33 2.63062763516969 3.19531552651385 1 31.645314197636 313 1367 85 1300 1749 47 656 367 1408 157 33 106 M16556 GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/22 Gene Ontology BP GO:0051957 1.04045139562394e-08 1.66938632546144e-07 370 502.363636363636 367 9.45864909585971e-10 2 3.22950163281247 3.88024631473366 1 23.5088659462378 367 992 900 903 2 317 204 10 698 1119 14 107 M14537 GO_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. 191/208 Gene Ontology BP GO:0007033 1.92377339831675e-08 1.97691467186943e-07 200 1283.18181818182 370 1.74888492285367e-09 8 1.39204376794291 -1.30505674105272 -1 9.95859076470663 198 1484 3819 2752 108 8 202 370 2118 2999 57 108 M16957 GO_DETECTION_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CALCIUM_ION.html The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. 10/20 Gene Ontology BP GO:0005513 1.08567242684308e-07 2.6865217663753e-07 55 659.090909090909 372 9.86974982199686e-09 3 3.41558152557705 3.41558152557705 1 24.1082412031352 51 1032 1094 547 1811 109 3 372 41 2089 101 109 M16290 GO_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of dendrite development. 162/194 Gene Ontology BP GO:0050773 4.62648281053891e-08 1.97760774550163e-07 205 514 373 4.20589355257399e-09 105 2.3144937935418 2.62915803588079 1 16.6323032966317 205 1523 493 424 936 105 177 373 321 802 295 110 M13997 GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. 51/57 Gene Ontology BP GO:0045992 8.20493655823647e-08 2.37677062514889e-07 75 594.727272727273 374 7.4590335129463e-09 72 2.8425008004149 3.33189377093179 1 20.2074944415984 72 315 272 585 1780 316 352 1337 595 544 374 111 M15430 GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION.html The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. 405/616 Gene Ontology BP GO:0048667 3.60581677221863e-19 3.72841454247407e-17 180 477.181818181818 379 3.27801524747147e-20 23 2.49504661646321 2.85831864337184 1 44.1243988428894 179 1294 23 359 1066 97 501 478 809 64 379 112 M11037 GO_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMISSION_OF_NERVE_IMPULSE.html The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. 42/102 Gene Ontology BP GO:0019226 5.08556700529553e-09 8.54265100203614e-08 915 625.636363636364 381 4.62324274277404e-10 47 3.50855025221564 3.62989076048008 1 26.651694457501 911 381 205 394 47 1191 2021 280 328 293 831 113 M16602 GO_NEURAL_CREST_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. 82/108 Gene Ontology BP GO:0014033 4.77677069753147e-12 1.36357754942417e-10 345 587 382 4.34251881594714e-13 116 3.177958734357 3.4770694225478 1 33.7225147953652 343 136 116 538 1539 571 382 261 1452 186 933 114 M11134 GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. 186/294 Gene Ontology BP GO:0051146 9.85850956869075e-11 2.20536754918837e-09 385 515.545454545455 384 8.96228142648411e-12 153 2.64061627494286 3.10603490800658 1 24.5565636802991 384 1479 153 399 1033 253 583 177 795 223 192 115 M10875 GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CREB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. 30/37 Gene Ontology BP GO:0032793 1.21772613517643e-07 2.87618259237356e-07 80 941.545454545455 386 1.10702382052638e-08 61 2.33729654256548 2.61883807433137 1 16.3869332012048 77 2361 1648 1079 1910 278 72 61 196 2289 386 116 M16847 GO_INNER_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. 123/188 Gene Ontology BP GO:0042472 9.40673083108618e-08 2.51115998606105e-07 390 666.545454545455 386 8.55157384845267e-09 10 2.53637891945802 2.85802179466108 1 17.9536900127414 386 10 319 1396 1676 210 637 728 1377 301 292 117 M13394 GO_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 100/158 Gene Ontology BP GO:0006865 2.75882746544229e-08 1.97691467186943e-07 4290 1824.81818181818 388 2.50802500003486e-09 54 2.58645640098875 -2.19153428032961 -1 18.600382203514 4290 54 339 388 343 3210 3532 3416 319 242 3940 118 M10531 GO_CIRCULATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. 359/596 Gene Ontology BP GO:0003013 3.22899923121187e-25 7.9076491699099e-23 355 571.818181818182 392 2.93545384655624e-26 8 2.77704887676504 3.1861392205109 1 66.1281908193288 353 1330 8 30 1006 294 947 392 1369 65 496 119 M14070 GO_REGULATION_OF_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GASTRULATION.html Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. 49/69 Gene Ontology BP GO:0010470 1.0182625896712e-07 2.6098603439058e-07 65 548.363636363636 392 9.25693306182853e-09 64 3.15178257084164 3.56385996824245 1 22.2802982241644 64 339 288 989 1748 343 432 575 626 392 236 120 M11939 GO_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHESION.html The attachment of a cell to the underlying substrate via adhesion molecules. 210/262 Gene Ontology BP GO:0031589 1.51417545715045e-12 4.72849557189333e-11 45 515 393 1.37652314286499e-13 42 2.48545773440437 2.76984809617297 1 27.5832625423081 42 1431 106 884 486 124 629 316 1112 142 393 121 M11606 GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 493/649 Gene Ontology BP GO:0051962 4.91471668277342e-17 3.46487526135526e-15 310 492.909090909091 396 4.46792425706673e-18 39 2.4427319510109 2.74425163737086 1 38.0082366238162 309 1259 39 366 844 60 713 515 815 106 396 122 M10470 GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE.html Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. 48/70 Gene Ontology BP GO:0060688 9.37608770133037e-08 2.5101804415587e-07 490 497.454545454545 397 8.52371645538724e-09 140 3.20442397712871 3.72008858436414 1 22.7128032524481 489 376 387 140 1672 461 397 414 301 507 328 123 M15904 GO_PATTERN_SPECIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_SPECIFICATION_PROCESS.html Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. 382/609 Gene Ontology BP GO:0007389 8.16697389017571e-10 1.57028634342924e-08 400 572.636363636364 397 7.42452172109772e-11 10 2.33491039367889 2.56263606326485 1 19.5523238801234 397 1324 178 944 350 10 558 755 1524 181 78 124 M11021 GO_ADULT_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_WALKING_BEHAVIOR.html The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 43/79 Gene Ontology BP GO:0007628 2.94945100474491e-08 1.97691467186943e-07 400 437.454545454545 398 2.68131913117001e-09 20 2.93945141331632 3.50678429462831 1 21.1543649654806 259 398 506 478 397 321 719 535 20 935 244 125 M12414 GO_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 55/110 Gene Ontology BP GO:0051952 2.65723094692822e-08 1.97691467186943e-07 1425 700.181818181818 398 2.41566452638465e-09 260 2.79726895566988 3.11219719976597 1 20.1256491672356 1421 290 321 442 307 1351 1994 260 584 398 334 126 M13500 GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 24/29 Gene Ontology BP GO:0030206 1.30675154426805e-07 2.99670524173448e-07 85 566.818181818182 398 1.18795601989657e-08 81 3.53487782413825 3.69408673049284 1 24.773188487753 81 729 604 398 1970 235 116 311 173 915 703 127 M13527 GO_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. 82/126 Gene Ontology BP GO:0021675 4.24222323858372e-08 1.97691467186943e-07 465 451.818181818182 398 3.85656665489619e-09 99 2.5175883181235 2.81719550616524 1 18.1021091675078 461 128 398 146 800 208 865 696 923 246 99 128 M13677 GO_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. 610/798 Gene Ontology BP GO:0035295 3.42950507292879e-13 1.21812878659066e-11 400 922.545454545455 399 3.42950507292931e-14 3 2.51684483316899 2.78738833709538 1 29.532977363902 399 1230 4442 28 321 3 786 1205 1517 63 154 129 M16566 GO_WALKING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_WALKING_BEHAVIOR.html The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. 43/79 Gene Ontology BP GO:0090659 2.94945100474491e-08 1.97691467186943e-07 400 438.090909090909 399 2.68131913117001e-09 21 2.93945141331632 3.50678429462831 1 21.1543649654806 260 399 507 479 398 322 720 532 21 936 245 130 M12792 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_CALCIUM_ION_SIGNALING.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. 45/56 Gene Ontology BP GO:0010882 4.49118727714763e-08 1.97691467186943e-07 180 486.727272727273 401 4.08289760802993e-09 12 2.39300106854161 2.66009714429683 1 17.2006978821333 178 397 977 609 894 110 115 401 586 1075 12 131 M16018 GO_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. 253/386 Gene Ontology BP GO:0042692 3.84947897204412e-11 9.42717139837963e-10 415 578.181818181818 401 3.49952633828315e-12 139 2.53794678428725 2.93759440066793 1 24.6083610552865 414 1399 139 401 1461 270 586 147 995 177 371 132 M12211 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_MEMBRANE_REPOLARIZATION.html Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. 20/40 Gene Ontology BP GO:0099623 5.08555312559043e-08 2.02998167617902e-07 1105 639.909090909091 402 4.62323022104442e-09 13 3.83494987319346 4.9262936638145 1 27.5858447566589 1105 762 383 75 1232 1376 1558 13 98 402 35 133 M15744 GO_NEUROMUSCULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS.html Any process pertaining to the functions of the nervous and muscular systems of an organism. 107/199 Gene Ontology BP GO:0050905 1.2131916169255e-07 2.87033193211408e-07 355 641.363636363636 402 1.10290153075186e-08 50 2.4760845602259 2.7522696810772 1 17.3690636087306 352 50 402 1113 1907 238 857 411 1137 313 275 134 M13648 GO_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. 563/777 Gene Ontology BP GO:0007507 1.04115248118025e-12 3.38774999645573e-11 195 815.545454545455 403 1.04115248118074e-13 33 2.46901810763185 2.93186403868978 1 27.7859409667433 192 1236 4440 403 590 33 640 174 1150 68 45 135 M14502 GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT_BETWEEN_ENDOSOMAL_COMPARTMENTS.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. 27/30 Gene Ontology BP GO:0098927 1.34667093849856e-08 1.95814371151056e-07 350 1925 404 1.22424631521986e-09 25 0.916229143302111 -0.961986622739369 -1 6.52008294608037 349 3126 3881 4404 25 129 111 404 4199 4203 344 136 M15858 GO_TRYPTOPHAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRYPTOPHAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. 7/13 Gene Ontology BP GO:0006568 2.75140635350155e-08 1.97691467186943e-07 410 973.909090909091 408 2.75140638756762e-09 18 3.73505951899064 -3.73505951899064 -1 26.910733515208 408 1117 4577 1376 416 218 18 206 138 1842 397 137 M15056 GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. 69/101 Gene Ontology BP GO:0042475 1.0224842830406e-07 2.61354764004912e-07 320 712.272727272727 410 9.29531209601953e-09 204 2.88740084571133 3.16204225259771 1 20.3999569931443 317 233 410 1507 1755 204 386 538 1397 685 403 138 M16748 GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structure of the retina is generated and organized. 54/80 Gene Ontology BP GO:0060042 2.6111911888573e-08 1.97691467186943e-07 1115 631.727272727273 412 2.37381019986332e-09 290 2.95829970632197 3.24197002428526 1 21.290735774551 1112 306 349 412 290 1161 1383 305 445 363 823 139 M10110 GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS.html The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 1008/1359 Gene Ontology BP GO:0048646 7.25031510054742e-18 6.2473548449717e-16 335 880.454545454545 413 7.25031510054745e-19 28 2.37773890035249 2.58948867659569 1 38.9031327213958 413 1169 4224 335 250 232 751 333 1402 28 548 140 M12264 GO_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CONTRACTION.html A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. 118/194 Gene Ontology BP GO:0006941 5.15210942564955e-09 8.62329681926163e-08 1345 587.818181818182 413 4.68373585246829e-10 3 2.70339795087056 3.24514139007466 1 20.4977264944225 1345 3 206 63 230 1103 1836 501 413 258 508 141 M14932 GO_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_DEVELOPMENT.html The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. 188/268 Gene Ontology BP GO:0060485 1.39465519019552e-17 1.11885010344478e-15 380 585.363636363636 413 1.2678683547232e-18 33 2.83413064935078 3.24768368647135 1 45.6179697472988 380 1471 33 413 1422 146 487 463 1346 92 186 142 M13335 GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. 86/122 Gene Ontology BP GO:0031032 8.07512069845713e-08 2.36014677197996e-07 1215 731.727272727273 414 7.34101908623203e-09 62 2.90196426194448 3.48593301890235 1 20.642136213807 1212 113 314 408 1507 1398 1745 62 213 663 414 143 M13801 GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 562/821 Gene Ontology BP GO:0000904 1.97140998549667e-17 1.52882844375267e-15 220 878.818181818182 415 1.97140998549668e-18 29 2.48720804364476 2.79577005510118 1 39.6561313243406 216 1234 4450 333 956 134 559 415 932 29 409 144 M16477 GO_INNERVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNERVATION.html The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. 26/39 Gene Ontology BP GO:0060384 2.34523169206498e-07 4.4145377289725e-07 95 800.909090909091 415 2.13202903824554e-08 42 3.31748978478623 3.35867666978937 1 22.6403701774237 91 677 415 710 2975 259 374 42 1845 351 1071 145 M10925 GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of neuron differentiation. 374/480 Gene Ontology BP GO:0045666 2.51566200120466e-10 5.29654990570375e-09 240 550.181818181818 416 2.2869654559021e-11 62 2.34788649808381 2.65898737998275 1 20.8575840380138 416 1318 163 396 820 62 969 815 615 238 240 146 M12205 GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_GUIDANCE.html Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. 32/38 Gene Ontology BP GO:1902668 7.95230100269336e-08 2.35082951496393e-07 420 635.272727272727 416 7.22936480922161e-09 34 2.97228428311696 3.54250839131745 1 21.150584922268 256 554 416 932 1489 416 216 34 1879 389 407 147 M12932 GO_TISSUE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_MIGRATION.html The process in which the population of cells that make up a tissue undergo directed movement. 125/181 Gene Ontology BP GO:0090130 7.66315713442691e-08 2.3019154387662e-07 265 715.909090909091 417 6.96650672850373e-09 47 2.51250503506257 2.78856236609332 1 17.8860917111238 264 1596 270 1120 1458 73 417 663 1562 405 47 148 M16960 GO_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. 174/259 Gene Ontology BP GO:0048592 1.44964737043581e-15 8.3274187835035e-14 225 553.818181818182 418 1.31786124585074e-16 51 2.98601861687733 3.51863012454316 1 42.0369346931654 224 1504 51 888 1043 249 807 418 518 148 242 149 M10363 GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. 220/300 Gene Ontology BP GO:0045665 3.37521890227893e-08 1.97691467186943e-07 420 536.181818181818 420 3.06838086732838e-09 81 2.52774095592206 2.94088572645723 1 18.1755653383331 419 1429 242 460 966 81 355 420 945 430 151 150 M13572 GO_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION.html A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. 174/242 Gene Ontology BP GO:0007369 3.04196636236646e-08 1.97691467186943e-07 85 588.181818181818 420 2.76542400402554e-09 66 2.56116680560686 2.95059993272802 1 18.4174074066846 83 1516 298 992 420 66 288 581 1261 804 161 151 M14319 GO_OLFACTORY_LOBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_LOBE_DEVELOPMENT.html The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. 44/61 Gene Ontology BP GO:0021988 4.7498617532714e-08 1.98252330758246e-07 615 554.272727272727 421 4.31805623256569e-09 162 2.97468605870673 3.44888160992211 1 21.405344025821 614 409 419 162 963 273 571 607 1390 421 268 152 M15685 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 98/149 Gene Ontology BP GO:0021954 6.14499746848117e-07 9.34095825574743e-07 245 769.636363636364 421 5.58636289535515e-08 100 2.72102188843782 3.27133240834802 1 17.5935260905002 268 100 421 827 3020 258 244 241 2073 433 581 153 M16206 GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOVASCULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiovascular system over time, from its formation to the mature structure. The cardiovascular system is the anatomical system that has as its parts the heart and blood vessels. 880/1179 Gene Ontology BP GO:0072358 6.88420633103548e-20 7.449351641467e-18 250 906.272727272727 422 6.88420633103551e-21 23 2.46598913189507 2.75883058052223 1 45.4705854786698 248 1192 4603 674 422 89 676 246 1547 23 249 154 M10737 GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN.html Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. 9/16 Gene Ontology BP GO:2000047 5.46539207105402e-07 8.49097472674937e-07 325 1195.72727272727 423 5.46539341522745e-08 51 2.01382322797222 -2.2053588363721 -1 13.0815932007806 322 1086 4258 1537 3010 423 51 267 199 1818 182 155 M14191 GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 183/238 Gene Ontology BP GO:0031345 2.3828082304503e-08 1.97691467186943e-07 510 533.545454545455 423 2.16618932387125e-09 125 2.47805400721538 2.73747944174155 1 17.816071277341 506 1490 318 423 220 125 403 801 850 480 253 156 M16442 GO_CIRCULATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCULATORY_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. 880/1179 Gene Ontology BP GO:0072359 6.88420633103548e-20 7.449351641467e-18 250 914.727272727273 423 6.88420633103551e-21 24 2.46598913189507 2.75883058052223 1 45.4705854786698 249 1193 4623 675 423 90 677 310 1548 24 250 157 M12628 GO_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CONTRACTION.html A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. 219/347 Gene Ontology BP GO:0006936 9.33961562253215e-14 3.7788896949254e-12 610 584.454545454545 424 8.49055965684777e-15 79 2.59641371133945 3.05288581268522 1 31.894628865032 609 1419 79 375 424 519 1349 377 846 89 343 158 M16923 GO_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSSIFICATION.html Any process that modulates the frequency, rate or extent of bone formation. 196/250 Gene Ontology BP GO:0030278 2.20685942792336e-10 4.71032886152632e-09 920 711.454545454545 425 2.00623584376794e-11 160 2.58455104289391 2.77342796565008 1 23.1135007343486 920 1466 160 182 249 239 1150 1130 1580 325 425 159 M14533 GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 498/622 Gene Ontology BP GO:0010975 2.64450134018178e-17 1.95315313267711e-15 430 498.818181818182 426 2.40409212743797e-18 37 2.4454307144748 2.77282722413861 1 38.7073823559464 426 1252 37 342 623 83 874 657 704 111 378 160 M15828 GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. 161/235 Gene Ontology BP GO:0060041 8.23418935510919e-13 2.75638007692972e-11 235 504.454545454545 427 7.48562668646568e-14 98 2.6787876244965 2.93890843287956 1 30.4152191729109 235 1512 98 889 427 111 725 553 718 118 163 161 M16294 GO_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXONOGENESIS.html Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. 197/250 Gene Ontology BP GO:0050770 1.32144806788142e-08 1.94579046197855e-07 430 545 428 1.20131643256254e-09 191 2.47491453847088 3.01108018172011 1 17.8117648353131 428 1453 220 440 215 311 1026 191 867 361 483 162 M11147 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 22/37 Gene Ontology BP GO:0055012 3.05532331773976e-08 1.97691467186943e-07 395 646 429 2.77756669106508e-09 53 2.85118725887911 3.0293494189897 1 20.5157578433975 391 755 822 1004 429 342 385 53 1493 1150 282 163 M12572 GO_MUSCLE_STRUCTURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_STRUCTURE_DEVELOPMENT.html The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. 452/653 Gene Ontology BP GO:0061061 2.04066806003697e-18 1.82600547756769e-16 435 587.363636363636 431 1.85515278185179e-19 28 2.57887074222899 2.99486711093212 1 43.6902659440269 431 1282 28 876 1216 103 863 416 981 74 191 164 M11740 GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 306/414 Gene Ontology BP GO:0051961 1.3355386246128e-12 4.2332638179706e-11 440 485.181818181818 436 1.21412602237601e-13 75 2.58444616418773 3.09704518447072 1 28.820341909868 529 1349 103 436 436 75 569 733 775 226 106 165 M13981 GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphatidylinositol. 21/23 Gene Ontology BP GO:0046856 1.76995925203499e-07 3.65864966668983e-07 405 1224.36363636364 436 1.60905399493908e-08 51 1.16454207578334 -1.36146201727438 -1 7.97658808412603 404 798 3166 1743 2207 392 229 436 51 3757 285 166 M13165 GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. 86/157 Gene Ontology BP GO:0055007 6.39371786138834e-08 2.15267505130535e-07 125 494.818181818182 437 5.81247095200439e-09 102 2.59406721008719 3.03129773002592 1 18.5518890690852 267 124 503 973 1276 182 437 102 940 515 124 167 M13461 GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of dendrite development. 91/107 Gene Ontology BP GO:1900006 5.10440266737472e-08 2.02998167617902e-07 110 581.545454545455 437 4.64036616891473e-09 84 2.12472007363879 2.55045654498842 1 15.2332564985897 110 116 1276 622 1032 84 154 516 437 1905 145 168 M15294 GO_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_FORMATION.html The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 44/51 Gene Ontology BP GO:0060343 3.08909170909331e-10 6.35997509841202e-09 5 979.818181818182 437 2.80826519047915e-11 4 3.55493216239313 3.78093364472161 1 31.3337218233989 4 1753 166 1306 3998 428 369 1164 803 350 437 169 M16099 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. 16/30 Gene Ontology BP GO:0055015 3.34263591557438e-08 1.97691467186943e-07 440 522.272727272727 437 3.03875996941974e-09 24 2.73390113686624 2.77354165936447 1 19.6671715365723 437 854 889 601 536 333 152 24 163 1510 246 170 M14420 GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE_BY_CARDIAC_CONDUCTION.html A cardiac conduction process that modulates the frequency or rate of heart contraction. 37/62 Gene Ontology BP GO:0086091 8.34455612682257e-08 2.39822233836352e-07 440 601.272727272727 438 7.58596040302721e-09 154 3.36354247055026 3.86938996470418 1 23.9181745234585 438 472 285 687 1543 405 624 154 1404 306 296 171 M15968 GO_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. 124/190 Gene Ontology BP GO:0048593 2.51780206638558e-08 1.97691467186943e-07 600 435.727272727273 441 2.288910995637e-09 8 2.81510595118031 3.21752412294162 1 20.2547030560103 600 8 236 483 441 269 1000 685 563 311 197 172 M11227 GO_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DIFFERENTIATION.html The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. 179/262 Gene Ontology BP GO:0001649 9.54718073888256e-08 2.5312268933345e-07 155 832.727272727273 442 8.67925559381334e-09 121 2.65008573175065 2.83098196671187 1 18.7537445017952 151 1527 390 1062 1690 121 186 293 1942 1356 442 173 M12259 GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. 36/55 Gene Ontology BP GO:0043534 3.09388851359264e-08 1.97691467186943e-07 25 429.909090909091 443 2.81262596100218e-09 3 2.66519169851402 2.87204781357558 1 19.1700463223125 103 533 624 1181 443 74 23 21 840 884 3 174 M16349 GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. 911/1347 Gene Ontology BP GO:0007417 3.7278924713454e-10 7.50904054942431e-09 495 980.454545454545 445 3.72789247197078e-11 108 2.37417276518806 2.75614930086771 1 20.7039459405216 493 1185 4616 365 445 286 1140 405 1357 108 385 175 M11940 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. 103/126 Gene Ontology BP GO:0048640 3.77938082138589e-08 1.97691467186943e-07 495 460.818181818182 447 3.43580080573809e-09 64 2.68551830905191 3.10714476684922 1 19.3171130261185 494 64 265 566 667 203 560 389 1245 447 169 176 M16151 GO_AORTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AORTA_MORPHOGENESIS.html The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. 44/54 Gene Ontology BP GO:0035909 8.39416885816193e-09 1.37045851568517e-07 35 984.909090909091 448 7.63106262744557e-10 34 3.88457801310679 4.25471142540192 1 28.6596235226726 34 2291 211 1352 3604 284 299 1212 448 715 384 177 M11126 GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_AMINO_3_HYDROXY_5_METHYL_4_ISOXAZOLE_PROPIONATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. 13/20 Gene Ontology BP GO:2000311 2.21901922571687e-07 4.25251089673006e-07 250 632.545454545455 452 2.01729040867017e-08 71 4.08576753807987 4.32396479046135 1 27.9813198514357 247 935 452 712 2386 380 71 137 349 692 597 178 M13864 GO_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MIGRATION.html The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. 121/181 Gene Ontology BP GO:0001764 3.91168920697233e-08 1.97691467186943e-07 365 556.727272727273 453 3.55608116047615e-09 23 2.80969359326274 3.38028259237004 1 20.2155436675194 364 23 246 707 1392 668 354 163 818 453 936 179 M11578 GO_ADULT_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_LOCOMOTORY_BEHAVIOR.html Locomotory behavior in a fully developed and mature organism. 85/161 Gene Ontology BP GO:0008344 3.11619068229617e-08 1.97691467186943e-07 455 462.727272727273 454 2.83290066039587e-09 91 2.52670755464425 3.12844271332681 1 18.1680884931722 649 133 585 114 451 454 732 630 211 1040 91 180 M15882 GO_NOTOCHORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTOCHORD_DEVELOPMENT.html The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. 39/52 Gene Ontology BP GO:0030903 4.3742828191897e-07 7.09182507236574e-07 455 802.636363636364 455 3.97662153539376e-08 97 3.19436860376597 3.7255624430086 1 21.0861875005709 97 465 333 1021 2833 424 455 1900 492 454 355 181 M14661 GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. 48/59 Gene Ontology BP GO:0050775 3.40662836438516e-08 1.97691467186943e-07 130 653.181818181818 456 3.09693492466881e-09 128 2.18962148684299 2.58948411767459 1 15.7292098223751 128 456 1818 667 549 281 243 209 730 1834 270 182 M12465 GO_EAR_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_DEVELOPMENT.html The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 227/339 Gene Ontology BP GO:0043583 1.48701854211412e-13 5.71826221194794e-12 305 671.636363636364 457 1.35183503828565e-14 52 2.68095789880378 3.01627958176366 1 32.4163439694501 305 1420 83 905 1847 107 615 457 1415 182 52 183 M14538 GO_CARDIOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. 110/192 Gene Ontology BP GO:0035051 1.06427193903677e-07 2.66239641523554e-07 550 519 457 9.67519991383629e-09 42 2.73007170414186 3.22015186905098 1 19.2585428502059 546 42 326 551 1790 274 730 111 707 457 175 184 M15682 GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS.html The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. 139/167 Gene Ontology BP GO:0060560 5.69414162152057e-08 2.0634742747708e-07 165 730.545454545455 461 5.1764925171809e-09 163 2.27137868346083 2.62748829456612 1 16.2751156467687 310 1558 461 163 1163 165 853 1197 1594 342 230 185 M13530 GO_PHAGOSOME_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_ACIDIFICATION.html Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. 25/30 Gene Ontology BP GO:0090383 3.16004577399103e-08 1.97691467186943e-07 110 1243.18181818182 464 2.8727689267104e-09 55 1.66782558583053 -1.45426150783044 -1 11.9539220990065 109 2386 2879 3289 464 104 55 165 1023 3002 199 186 M10516 GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. 52/70 Gene Ontology BP GO:0055024 5.81146510648835e-08 2.0762333639785e-07 465 584.636363636364 465 5.28315023636597e-09 251 2.88442647436235 3.29629960659816 1 20.6899800546122 465 329 369 260 1184 251 359 634 1157 829 594 187 M12684 GO_PONS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PONS_DEVELOPMENT.html The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. 10/20 Gene Ontology BP GO:0021548 4.73709534771373e-07 7.56926670773076e-07 435 1193.90909090909 465 4.30645124337938e-08 71 2.85512979402302 2.85512979402302 1 18.7476550974365 435 2551 1936 1424 2878 465 119 71 236 2682 336 188 M16634 GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT.html Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 320/389 Gene Ontology BP GO:0010976 4.39869803540481e-08 1.97691467186943e-07 410 559.636363636364 466 3.99881647577522e-09 102 2.35621291362478 2.70216797204002 1 16.934528927273 409 1346 268 445 845 102 943 480 550 466 302 189 M10347 GO_METENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. 120/189 Gene Ontology BP GO:0022037 8.75919960523455e-08 2.45512816355666e-07 415 513.272727272727 467 7.96290904907102e-09 16 2.70420618605594 3.04881538951836 1 19.1777358395036 415 16 490 467 1584 230 503 773 292 830 46 190 M11608 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. 35/45 Gene Ontology BP GO:0060043 5.34781684690614e-08 2.05087954115883e-07 940 601 469 4.86165179718388e-09 223 3.10592963998064 3.47577602086445 1 22.3053929064038 939 469 287 223 1089 440 722 901 428 668 445 191 M16736 GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS.html Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. 51/76 Gene Ontology BP GO:0021955 4.55061768005108e-07 7.33680667542538e-07 470 894.909090909091 471 4.13692601939053e-08 211 2.39144590836501 2.84811699378903 1 15.7195605384715 470 361 1008 812 2850 398 471 238 1983 1042 211 192 M10631 GO_CARDIAC_CHAMBER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_MORPHOGENESIS.html The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. 133/183 Gene Ontology BP GO:0003206 8.22409866846475e-13 2.75638007692972e-11 175 504.818181818182 472 7.47645333497077e-14 13 2.79057361182729 3.15928738622463 1 31.6891678838541 173 1568 97 525 992 53 472 556 915 189 13 193 M14694 GO_COCHLEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_DEVELOPMENT.html The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. 45/75 Gene Ontology BP GO:0090102 5.75227766083372e-08 2.07580109259326e-07 360 541.090909090909 472 5.22934346476081e-09 112 3.03899389918035 3.47954397623672 1 21.8050487416512 357 384 450 112 1172 530 887 639 443 472 506 194 M10207 GO_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DEPOLARIZATION.html The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. 47/80 Gene Ontology BP GO:0051899 4.18965923285908e-08 1.97691467186943e-07 1445 725.909090909091 473 3.80878119331505e-09 101 2.94609087625802 3.65509690826785 1 21.2024026807729 1444 340 375 101 783 1613 1702 145 354 473 655 195 M12693 GO_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PAIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 28/52 Gene Ontology BP GO:0048265 2.03787187192774e-08 1.97691467186943e-07 220 690.454545454545 474 1.85261080982241e-09 7 4.02274669869997 4.57869227122113 1 28.9922022956636 218 1868 474 1343 376 448 1241 7 710 729 181 196 M13079 GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 87/98 Gene Ontology BP GO:0060998 4.46519444003112e-08 1.97691467186943e-07 300 557.818181818182 474 4.05926775514384e-09 130 2.3087376553519 2.75403260513825 1 16.5910368466077 296 130 848 596 876 474 296 242 406 1257 715 197 M15611 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 40/48 Gene Ontology BP GO:0050654 6.10602489184209e-08 2.11120813526401e-07 110 664.818181818182 474 5.55093187392068e-09 108 2.99416939629072 3.24222529266618 1 21.4580251582563 108 474 556 387 1235 394 241 421 1859 726 912 198 M16368 GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUCOPOLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving mucopolysaccharide. 105/130 Gene Ontology BP GO:1903510 4.80909186242577e-08 1.98933140232619e-07 475 674.272727272727 474 4.37190178868196e-09 16 2.63881268591457 2.88332445812519 1 18.9714453744002 474 56 264 16 978 1072 994 1089 458 252 1764 199 M16576 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 203/279 Gene Ontology BP GO:0007178 3.06498315936828e-08 1.97691467186943e-07 480 712.181818181818 476 2.78634836551712e-09 63 2.39480178503084 2.73109141401481 1 17.2137263916365 342 1477 476 530 431 63 476 967 1590 1393 89 200 M10170 GO_HINDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). 160/247 Gene Ontology BP GO:0030902 6.00162034128311e-08 2.09491454642436e-07 195 538.090909090909 477 5.45601864091626e-09 105 2.45947299663179 2.69496021408634 1 17.6148022859037 191 1526 477 493 1219 115 291 383 502 617 105 201 M13376 GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS.html The process in which the anatomical structures of cardiac muscle tissue are generated and organized. 72/112 Gene Ontology BP GO:0055008 6.96901189009123e-11 1.63771779417144e-09 510 636.545454545455 481 6.33546535482908e-12 147 3.44669368740256 4.14032647015333 1 32.5680030143176 507 180 147 512 1796 481 1480 943 391 360 205 202 M11421 GO_REGULATION_OF_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AXON_GUIDANCE.html Any process that modulates the frequency, rate or extent of axon guidance. 37/47 Gene Ontology BP GO:1902667 8.16953979281651e-08 2.37283824319446e-07 490 572.454545454545 487 7.42685463289678e-09 129 3.09460902022754 3.47556748857148 1 22.0121783162435 258 490 353 487 1521 524 226 129 1366 370 573 203 M11569 GO_SARCOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOMERE_ORGANIZATION.html The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. 35/61 Gene Ontology BP GO:0045214 6.95936295197305e-08 2.21185701128363e-07 570 547.636363636364 489 6.32669379283805e-09 89 3.57198862666079 3.64796637702281 1 25.5428810178443 566 489 315 391 1369 1027 997 109 89 541 131 204 M12538 GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. 63/94 Gene Ontology BP GO:0003229 7.16302588014324e-10 1.39454223515927e-08 365 663.454545454545 490 6.51184171134132e-11 176 3.25747432441062 3.80400986801558 1 27.5036935248534 361 227 176 490 1549 699 1434 1107 233 458 564 205 M12096 GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 109/202 Gene Ontology BP GO:0030799 2.59104160823987e-08 1.97691467186943e-07 495 952.090909090909 492 2.35549239886888e-09 79 2.46373814214399 2.55702269698035 1 17.7124934041754 492 79 544 1511 285 176 843 2495 3426 310 312 206 M12381 GO_PATTERNING_OF_BLOOD_VESSELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERNING_OF_BLOOD_VESSELS.html The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. 62/76 Gene Ontology BP GO:0001569 1.13562654249135e-06 1.56842892129879e-06 60 794.181818181818 493 1.03238829881386e-07 56 3.04399017778882 3.47044781441984 1 18.9557872278698 56 289 370 652 3335 209 493 1049 1251 894 138 207 M16952 GO_POSITIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSSIFICATION.html Any process that activates or increases the frequency, rate or extent of bone formation. 96/117 Gene Ontology BP GO:0045778 3.02689130728954e-08 1.97691467186943e-07 1275 710.909090909091 493 2.75171940812301e-09 99 2.64221262675659 3.0204651671208 1 19.0037885818207 1272 99 403 244 417 873 1581 492 1273 493 673 208 M12757 GO_PHAGOSOME_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOSOME_MATURATION.html A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. 41/49 Gene Ontology BP GO:0090382 5.09871218209485e-08 2.02998167617902e-07 385 1191.36363636364 495 4.63519300023858e-09 156 1.59218635381494 -1.47765658417672 -1 11.3868904861187 385 495 2952 2744 1029 156 219 343 1298 3247 237 209 M11967 GO_SYNAPTIC_VESICLE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYCLE.html A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. 85/129 Gene Ontology BP GO:0099504 3.07814061933757e-08 1.97691467186943e-07 1720 831.636363636364 496 2.79830969309593e-09 88 2.32996605187909 -2.20146341259392 -1 16.7446281351564 1718 88 496 395 437 749 1422 2217 215 432 979 210 M16538 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY_COUPLED_TO_CYCLIC_NUCLEOTIDE_SECOND_MESSENGER.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. 89/230 Gene Ontology BP GO:0007187 2.82546937903939e-08 1.97691467186943e-07 500 899.909090909091 498 2.5686085593882e-09 160 2.69814163913887 2.73452700857658 1 19.4084451025355 498 1658 366 2230 361 222 791 1148 2093 372 160 211 M12873 GO_CEREBRAL_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_DEVELOPMENT.html The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. 144/190 Gene Ontology BP GO:0021987 1.21515979349856e-09 2.26165540765951e-08 215 535.272727272727 499 1.10469072197249e-10 143 2.65359266920597 3.2966763630818 1 21.7826074032241 211 1542 185 143 964 173 648 502 705 316 499 212 M15830 GO_POST_ANAL_TAIL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_ANAL_TAIL_MORPHOGENESIS.html The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. 32/44 Gene Ontology BP GO:0036342 2.20033186912136e-08 1.97691467186943e-07 235 505.727272727273 499 2.00030171920727e-09 154 2.90438588060657 3.70994990346592 1 20.9006594938668 233 549 640 499 170 797 910 254 154 1084 273 213 M16129 GO_NEGATIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXONOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. 83/105 Gene Ontology BP GO:0050771 2.8327494796334e-08 1.97691467186943e-07 825 555.909090909091 499 2.5752268328257e-09 142 2.50193851917919 3.08720556051817 1 17.988880041497 821 142 495 985 369 499 566 156 1318 560 204 214 M13157 GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). 29/36 Gene Ontology BP GO:0001941 5.12646869657871e-08 2.03397493965704e-07 810 467.636363636364 500 4.66042619639668e-09 96 2.90897029348929 3.48205309264138 1 20.8950322246876 809 531 429 500 1034 562 184 96 325 525 149 215 M13915 GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_DEVELOPMENT.html Any apoptotic process that is involved in anatomical structure development. 27/38 Gene Ontology BP GO:1902742 9.01500747766075e-07 1.29067168595555e-06 580 963.454545454545 500 8.19546470160922e-08 190 2.71667917792133 2.92567199336322 1 17.1535528180056 578 706 1505 303 3218 443 500 364 218 2573 190 216 M14360 GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. 54/68 Gene Ontology BP GO:0030166 3.2643021403385e-08 1.97691467186943e-07 375 603.909090909091 500 2.96754744433942e-09 194 2.98121418011963 3.18530555459607 1 21.4565261371198 374 331 437 371 500 549 689 194 1336 814 1048 217 M12799 GO_NEPHRON_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. 101/140 Gene Ontology BP GO:0072009 1.29708099701779e-12 4.16228819249917e-11 700 650.727272727273 507 1.17916454274414e-13 18 3.11943069866196 3.43667885121682 1 34.8343321703374 696 51 102 18 1064 459 1179 1797 507 179 1106 218 M11807 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION_BY_REGULATION_OF_THE_RELEASE_OF_SEQUESTERED_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. 36/47 Gene Ontology BP GO:0010881 3.87786042540098e-08 1.97691467186943e-07 20 398.545454545455 508 3.52532772159511e-09 7 2.64334876244434 2.81043528636538 1 19.0120087290195 12 508 881 599 702 17 17 49 535 1057 7 219 M11764 GO_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. 109/145 Gene Ontology BP GO:0019722 1.0678681870919e-07 2.66423092468559e-07 800 855.363636363636 509 9.70789308114233e-09 26 2.55988235899993 2.78586011221882 1 18.0501119217697 799 26 313 443 1794 276 882 2249 1734 384 509 220 M16337 GO_AXONAL_FASCICULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONAL_FASCICULATION.html The collection of axons into a bundle of rods, known as a fascicle. 31/43 Gene Ontology BP GO:0007413 5.89537213820237e-08 2.08467047776528e-07 20 537.727272727273 510 5.35942936016501e-09 14 3.17509912650799 3.44970365513364 1 22.7803358625849 17 634 510 590 2138 49 21 14 998 821 123 221 M15014 GO_CONNECTIVE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONNECTIVE_TISSUE_DEVELOPMENT.html The progression of a connective tissue over time, from its formation to the mature structure. 206/273 Gene Ontology BP GO:0061448 8.87171872602393e-12 2.42824160189349e-10 370 911.363636363636 511 8.06519884187244e-13 122 2.63210469810741 2.90711897625438 1 27.1989252898187 366 1459 122 1315 1759 295 511 1351 2179 262 406 222 M11375 GO_CARDIAC_MYOFIBRIL_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MYOFIBRIL_ASSEMBLY.html The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. 22/41 Gene Ontology BP GO:0055003 9.33965776926432e-08 2.50783780632741e-07 550 569.272727272727 516 8.49059833250974e-09 23 3.70648832780254 4.07730698813581 1 26.2907532821645 550 739 511 516 1921 657 199 23 208 909 29 223 M15118 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. 71/84 Gene Ontology BP GO:0045669 4.98440389125438e-08 2.02079099099266e-07 590 515.090909090909 516 4.53127636743904e-09 210 2.78024778243394 2.97404921616907 1 19.9738924211384 587 214 455 210 1008 285 802 306 745 516 538 224 M10373 GO_CARDIAC_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_DEVELOPMENT.html The progression of a cardiac septum over time, from its initial formation to the mature structure. 113/145 Gene Ontology BP GO:0003279 3.77521008450785e-08 1.97691467186943e-07 630 524.727272727273 517 3.43200922662783e-09 20 2.43093283371878 2.8569694719231 1 17.4751410640771 627 20 517 173 665 566 1537 512 449 529 177 225 M11378 GO_CRANIAL_NERVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 37/59 Gene Ontology BP GO:0021602 6.44913129020312e-08 2.15972315171505e-07 460 705.454545454545 517 5.86284679932225e-09 34 2.52080830543753 3.10206224096387 1 18.0209101494574 456 517 854 824 1283 355 478 74 2078 807 34 226 M13460 GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOLAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. 70/97 Gene Ontology BP GO:0042439 1.06043284039152e-07 2.65752334514745e-07 160 797.363636363636 526 9.64029901369060e-09 72 2.21222042005712 -2.09287276674041 -1 15.5859495808815 160 223 1207 1828 1786 72 137 220 979 1633 526 227 M14930 GO_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_SYSTEM_PROCESS.html A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. 272/419 Gene Ontology BP GO:0003012 2.18631961712468e-14 1.00722229489912e-12 690 644.090909090909 529 1.98756328829518e-15 66 2.55273708782688 3.02636567977318 1 32.9382227572513 689 1372 66 385 395 529 1359 596 1243 84 367 228 M16217 GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_SALIVARY_GLAND_MORPHOGENESIS.html The process in which the branching structure of the salivary gland is generated and organized. 28/33 Gene Ontology BP GO:0060445 2.51270542538774e-07 4.62302030222585e-07 185 853.363636363636 531 2.28427792033967e-08 68 3.0498374036145 3.50969597870106 1 20.7386757335195 184 631 531 1167 2487 546 399 68 2389 478 507 229 M16573 GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. 24/31 Gene Ontology BP GO:0032331 3.32942042219682e-08 1.97691467186943e-07 175 718.090909090909 531 3.02674588416671e-09 16 2.7518150290571 3.12813332503273 1 19.7967817867385 175 1914 1145 1384 531 114 125 16 1306 1136 53 230 M10271 GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_HEART_DEVELOPMENT.html The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. 24/31 Gene Ontology BP GO:0060973 1.04819316464116e-06 1.46219466635784e-06 325 787.727272727273 532 9.52903330958759e-08 78 3.9799550439413 4.07887384884151 1 24.9499133309559 324 695 340 78 3474 532 686 1094 168 913 361 231 M13034 GO_MULTIVESICULAR_BODY_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. 34/34 Gene Ontology BP GO:0036257 6.29250256552149e-08 2.12948256567067e-07 25 1119.27272727273 538 5.72045704136495e-09 14 1.05011867820408 -0.938277749364563 -1 7.44811030264483 89 538 3647 2364 1266 23 14 247 993 3110 21 232 M12059 GO_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_MIGRATION.html The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 87/132 Gene Ontology BP GO:0043542 5.44249251687128e-08 2.05617623085131e-07 360 691.818181818182 541 4.94772059228269e-09 116 2.15270651659644 2.43807048593003 1 15.4224595412069 359 143 862 1208 1107 130 541 224 1916 1004 116 233 M14048 GO_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. 546/697 Gene Ontology BP GO:0001944 1.08432490181736e-11 2.91639524170878e-10 235 1010.36363636364 542 1.08432490182265e-12 80 2.55181495365096 2.76798883448811 1 26.146706129006 232 1245 4470 683 1186 175 542 277 1768 80 456 234 M14077 GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. 30/40 Gene Ontology BP GO:0046460 4.7953065259847e-08 1.98687099424816e-07 405 911 542 4.3593696640975e-09 119 2.16400083302982 -2.20657260346072 -1 15.5387443842731 402 638 1660 3270 975 452 481 119 542 1095 387 235 M14026 GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_OF_CELL_OR_SUBCELLULAR_COMPONENT.html The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. 1226/1793 Gene Ontology BP GO:0006928 7.12394453541073e-31 5.52461898721102e-28 505 1029.36363636364 543 7.12394453541072e-32 4 2.43659888535785 2.67517805661151 1 71.5652220559608 501 1155 4467 323 334 409 1300 543 1411 4 876 236 M16472 GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 30/40 Gene Ontology BP GO:0046463 4.7953065259847e-08 1.98687099424816e-07 405 914.727272727273 543 4.3593696640975e-09 150 2.16400083302982 -2.20657260346072 -1 15.5387443842731 403 639 1661 3271 976 453 482 150 543 1096 388 237 M10257 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 278/369 Gene Ontology BP GO:0090287 2.87777142771792e-08 1.97691467186943e-07 665 696.181818181818 547 2.6161558776013e-09 122 2.39054399866917 2.59775960750826 1 17.1829205371851 661 1394 312 122 378 177 1249 655 1793 547 370 238 M13006 GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS.html The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 166/326 Gene Ontology BP GO:0050953 7.38783232932886e-11 1.71053855778238e-09 325 782 547 6.71621120870631e-12 149 2.81411622998378 3.20177901222916 1 26.5126039041249 325 1525 149 1291 1268 449 881 547 1353 343 471 239 M14257 GO_HEAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_DEVELOPMENT.html The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. 787/1144 Gene Ontology BP GO:0060322 3.09810366574626e-08 1.97691467186943e-07 395 964 550 3.09810370893837e-09 186 2.37974329163965 2.79896119021324 1 17.1047754682546 392 1208 4484 393 550 186 990 635 1301 218 247 240 M16429 GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_ADHESION_MOLECULES.html The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. 170/262 Gene Ontology BP GO:0098742 8.65839097009654e-27 3.35729109865493e-24 280 629.909090909091 550 7.87126451826956e-28 4 3.05492068163034 3.02954996578099 1 77.2799318216086 277 1470 4 326 680 65 1003 810 1710 34 550 241 M16579 GO_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that modulates the frequency, rate or extent of lymphocyte migration. 32/59 Gene Ontology BP GO:2000401 3.38672407237935e-08 1.97691467186943e-07 550 1501.45454545455 550 3.07884011319569e-09 97 3.00668598857235 -2.81658347053668 -1 21.6408192784744 2875 550 550 97 539 2195 1262 4154 345 390 3559 242 M15515 GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 34/58 Gene Ontology BP GO:0071470 8.28064344910757e-08 2.38427190400356e-07 555 721.272727272727 551 7.52785796435012e-09 37 2.85711205802347 3.18818280541868 1 20.3077282493111 551 548 906 1466 1536 946 353 37 223 1294 74 243 M10535 GO_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COCAINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. 45/70 Gene Ontology BP GO:0042220 4.48727241299631e-08 1.97691467186943e-07 755 617.181818181818 552 4.0793386404744e-09 8 2.56195957222418 3.08242543304191 1 18.4231432165521 752 382 513 488 888 800 1755 18 633 552 8 244 M10301 GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 362/507 Gene Ontology BP GO:0010721 1.09920451852137e-14 5.44106236668079e-13 670 599.909090909091 555 9.99276835019432e-16 62 2.56189935840277 2.96840577356739 1 33.7962950389474 670 1327 62 447 555 226 799 882 1080 174 377 245 M11199 GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAYER_FORMATION_IN_CEREBRAL_CORTEX.html The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. 14/18 Gene Ontology BP GO:0021819 2.77017357005985e-07 4.97731305171957e-07 395 1191.90909090909 555 2.5183399262471e-08 48 1.85654501836952 2.18328216117234 1 12.5158668647492 395 990 2405 672 3654 555 444 48 65 3358 525 246 M12616 GO_MICROTUBULE_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_DEPOLYMERIZATION.html The removal of tubulin heterodimers from one or both ends of a microtubule. 12/16 Gene Ontology BP GO:0007019 1.26888211789875e-06 1.72533854312767e-06 475 1172.27272727273 558 1.15352986340512e-07 38 2.40918124974084 2.20723256302911 1 14.8713993322791 475 2038 2135 1331 3388 513 38 167 235 2017 558 247 M12937 GO_ENSHEATHMENT_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENSHEATHMENT_OF_NEURONS.html The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. 107/139 Gene Ontology BP GO:0007272 2.4077550840473e-08 1.97691467186943e-07 2625 1132.36363636364 558 2.18886828218055e-09 52 2.73918534131328 3.09823897440284 1 19.7054037115242 2621 52 329 426 234 1876 2015 1111 558 437 2797 248 M13182 GO_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT.html Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. 107/139 Gene Ontology BP GO:0008366 2.4077550840473e-08 1.97691467186943e-07 2625 1119.54545454545 559 2.18886828218055e-09 53 2.73918534131328 3.09823897440284 1 19.7054037115242 2622 53 330 427 235 1877 2016 960 559 438 2798 249 M12273 GO_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_PAIN.html The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. 71/149 Gene Ontology BP GO:0019233 3.39205892763795e-08 1.97691467186943e-07 1645 833.454545454545 560 3.08368998176203e-09 226 2.72817365993094 3.249393977115 1 19.6257322049912 1643 226 520 261 541 1115 2146 560 1081 589 486 250 M12218 GO_ANATOMICAL_STRUCTURE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. 59/76 Gene Ontology BP GO:0071695 5.51573288419328e-08 2.05617623085131e-07 520 715.636363636364 564 5.01430274771005e-09 303 2.85923501056291 3.38266911933928 1 20.5213031424449 520 303 504 584 1124 564 924 427 1476 967 479 251 M11450 GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. 814/1070 Gene Ontology BP GO:0051960 1.41263331718249e-18 1.28882016173532e-16 405 903 567 1.41263331718249e-19 27 2.38247840825045 2.69750009132666 1 40.7435019657937 405 1200 4301 336 567 78 854 856 990 27 319 252 M10902 GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_EXTENSION_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any neuron projection extension that is involved in neuron projection guidance. 15/17 Gene Ontology BP GO:1902284 3.70567966307723e-06 4.49024152924436e-06 150 1305.09090909091 568 3.36880536812564e-07 147 4.06848519271637 4.08635316641243 1 23.3679159593795 147 1997 467 1846 3812 568 389 419 2395 531 1785 253 M12489 GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING_INVOLVED_IN_EXOCYTOSIS.html The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. 36/42 Gene Ontology BP GO:0006904 1.26579521306285e-07 2.93105480790615e-07 255 1685.90909090909 568 1.1507229871744e-08 206 1.27089257775516 -1.29815285223481 -1 8.84744916858902 251 568 3470 3863 1944 267 206 298 3791 3547 340 254 M16466 GO_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION.html Long distance growth of a single axon process involved in cellular development. 53/63 Gene Ontology BP GO:0048675 1.63944178641354e-07 3.4611264211353e-07 130 697.727272727273 568 1.49040173507717e-08 80 2.48941677319166 3.0133380268026 1 17.2448086159154 126 319 685 583 2157 271 568 80 1699 753 434 255 M10067 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. 132/164 Gene Ontology BP GO:0050680 1.71402402082689e-07 3.57799630727121e-07 385 850.090909090909 569 1.55820377669712e-08 7 2.37789511982593 2.73081308658083 1 16.43019156534 382 7 883 1393 2186 352 435 548 1115 1481 569 256 M11804 GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_EXTENSION_INVOLVED_IN_AXON_GUIDANCE.html The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. 15/17 Gene Ontology BP GO:0048846 3.70567966307723e-06 4.49024152924436e-06 150 1305.36363636364 569 3.36880536812564e-07 148 4.06848519271637 4.08635316641243 1 23.3679159593795 148 1998 468 1847 3813 569 390 412 2396 532 1786 257 M12172 GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix. 71/92 Gene Ontology BP GO:0001954 8.61951617300296e-08 2.44742660185759e-07 1025 831.727272727273 570 7.83592410064755e-09 212 2.53544726356877 2.89753043347473 1 17.977604139881 442 212 481 1024 1566 223 570 1605 1738 1024 264 258 M13455 GO_SPINAL_CORD_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_PATTERNING.html The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. 17/34 Gene Ontology BP GO:0021511 7.75322638804989e-07 1.13196618712256e-06 510 991.909090909091 570 7.04839010948952e-08 92 3.16691184004924 3.15659015990752 1 20.2098943862217 508 858 1178 1735 3366 433 162 92 570 1699 310 259 M14841 GO_MUSCLE_FIBER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FIBER_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. 47/79 Gene Ontology BP GO:0048747 1.7007727781572e-07 3.55511937860083e-07 745 654.090909090909 570 1.5461571905821e-08 17 2.87711879391515 3.76210698133397 1 19.9119977707297 743 394 614 922 2182 570 183 105 217 1248 17 260 M10510 GO_CORONARY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORONARY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. 68/93 Gene Ontology BP GO:0060976 8.76064525577285e-08 2.45512816355666e-07 300 623.090909090909 574 7.96422327693775e-09 66 2.56710504254823 2.97009063133487 1 18.1997056328631 298 235 722 997 1586 574 550 66 453 743 630 261 M10964 GO_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of dendrite morphogenesis. 103/125 Gene Ontology BP GO:0048814 4.03816435405072e-08 1.97691467186943e-07 435 558.454545454545 574 3.67105857106582e-09 69 2.22509831325399 2.47018732583549 1 15.9858910783099 434 69 811 117 747 387 349 830 574 887 938 262 M11777 GO_SYNAPTIC_VESICLE_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_RECYCLING.html The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. 28/39 Gene Ontology BP GO:0036465 3.46512070216073e-08 1.97691467186943e-07 1215 978.454545454545 574 3.15010977885297e-09 180 1.8054663779207 -1.69967742998997 -1 12.9497781254806 1213 632 2379 778 574 537 400 517 239 3314 180 263 M13364 GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. 33/41 Gene Ontology BP GO:0048485 2.24417751174683e-07 4.28660014866913e-07 215 860.636363636364 577 2.04016158242825e-08 163 3.15055798843122 3.87359052041918 1 21.5388730899372 214 577 684 1072 2393 163 337 169 2264 1202 392 264 M11203 GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 11/13 Gene Ontology BP GO:0009313 2.49640971463011e-07 4.61127209296305e-07 580 1092 580 2.26946363445971e-08 43 1.44968316914372 -1.56609510143907 -1 9.8001317253222 580 1055 2710 1523 2690 346 84 43 573 2335 73 265 M14241 GO_RESPONSE_TO_BMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 97/151 Gene Ontology BP GO:0071772 1.33075119708839e-08 1.947165194985e-07 20 711.181818181818 581 1.20977382285266e-09 19 3.07333896347351 3.19027839273827 1 22.1449074461141 19 1629 221 925 1966 190 366 644 1173 581 109 266 M11014 GO_ENDOSOME_TO_LYSOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOSOME_TO_LYSOSOME_TRANSPORT.html The directed movement of substances from endosomes to lysosomes. 50/55 Gene Ontology BP GO:0008333 4.95210049971951e-08 2.01774734543894e-07 170 1450 582 4.5019096465355e-09 106 1.05013316992636 -1.08262996065726 -1 7.47474300656261 166 375 3833 2818 999 106 158 474 2774 3665 582 267 M15778 GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BMP_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. 97/151 Gene Ontology BP GO:0071773 1.33075119708839e-08 1.947165194985e-07 20 709.909090909091 583 1.20977382285266e-09 20 3.07333896347351 3.19027839273827 1 22.1449074461141 20 1630 222 926 1967 191 367 619 1174 583 110 268 M12883 GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_METABOLIC_PROCESS.html The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 13/31 Gene Ontology BP GO:0009072 1.64017877052581e-08 1.97691467186943e-07 590 634.090909090909 588 1.49107162068538e-09 50 3.44003947939399 -4.00159538937289 -1 24.7762101671406 744 1000 1395 586 51 588 249 87 50 1331 894 269 M10473 GO_REGULATION_OF_T_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus. 7/13 Gene Ontology BP GO:0010819 9.55412466692567e-07 1.35438919033891e-06 400 1345.63636363636 589 9.55412877458654e-08 35 3.16433214495803 -3.16433214495803 -1 19.9272733490183 400 2581 4242 785 3300 376 35 357 300 1837 589 270 M10957 GO_SPHINGOMYELIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOMYELIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine. 13/14 Gene Ontology BP GO:0006684 8.8431773781197e-08 2.45949219010107e-07 560 1084.36363636364 589 8.03925248507489e-09 77 1.91330077013267 -1.98593232805231 -1 13.5341086869767 589 1007 2310 1850 1601 560 77 252 557 2784 341 271 M13415 GO_BLOOD_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. 412/539 Gene Ontology BP GO:0048514 2.68640221549922e-21 3.47217486353274e-19 245 660.454545454545 589 2.44218383227201e-22 19 2.59990719676342 2.7731831786519 1 51.682159553292 244 1302 19 680 1174 265 703 589 1680 66 543 272 M10588 GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AXON_EXTENSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. 46/54 Gene Ontology BP GO:0030517 5.826094052201e-08 2.0762333639785e-07 635 863.181818181818 591 5.29644927862644e-09 166 2.78236821310094 3.30835720464371 1 19.9539148570747 633 411 561 1700 1187 917 535 166 2285 509 591 273 M11618 GO_CRANIAL_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. 57/92 Gene Ontology BP GO:0021545 5.1002109528107e-08 2.02998167617902e-07 1185 689.636363636364 591 4.63655551913432e-09 22 2.52271956027499 3.02799917110054 1 18.1079133351271 1185 285 591 242 1031 864 1213 461 1153 539 22 274 M12265 GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. 40/72 Gene Ontology BP GO:1903792 2.02092595110657e-07 3.99633168316993e-07 595 912.090909090909 594 1.83720557886309e-08 315 2.90303749751336 2.83051239830169 1 19.9332131874735 379 524 888 1509 2312 594 536 315 592 1465 919 275 M11732 GO_ANATOMICAL_STRUCTURE_ARRANGEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_ARRANGEMENT.html The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 32/39 Gene Ontology BP GO:0048532 5.37796594099948e-08 2.05112094454677e-07 600 846.545454545455 596 4.8890600658777e-09 162 2.5406569016456 3.15588504713516 1 18.225134060091 596 625 1070 291 1096 575 402 162 3192 1081 222 276 M14064 GO_RETINA_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_LAYER_FORMATION.html The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. 30/38 Gene Ontology BP GO:0010842 5.32845849258889e-08 2.04903449305918e-07 2705 1362.63636363636 598 4.84405329240507e-09 227 2.87822306623387 3.25346258635173 1 20.663029077955 2702 563 598 402 1087 3161 3851 424 227 591 1383 277 M14996 GO_DEVELOPMENTAL_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_CELL_GROWTH.html The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. 102/120 Gene Ontology BP GO:0048588 5.5714383794995e-08 2.05617623085131e-07 275 746.454545454545 598 5.06494410963148e-09 77 2.19857509811523 2.60386293643974 1 15.753481892566 273 77 837 772 1134 306 847 291 2681 598 395 278 M15980 GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. 61/73 Gene Ontology BP GO:0051057 3.50146147651419e-08 1.97691467186943e-07 145 687.454545454545 598 3.18314684749319e-09 142 3.07648373721737 3.29887061704136 1 22.1458186145501 142 254 243 598 1989 377 452 1548 652 622 685 279 M10985 GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. 21/23 Gene Ontology BP GO:2000050 1.19270626520704e-07 2.8474408681418e-07 345 768.363636363636 599 1.08427848169848e-08 74 2.10858023644487 2.29224915974756 1 14.7822473751476 344 795 1542 1377 1889 245 74 369 599 1029 189 280 M10876 GO_NEGATIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. 191/243 Gene Ontology BP GO:0030308 2.85113403284039e-08 1.97691467186943e-07 485 883.181818181818 600 2.59194006344566e-09 146 2.17110819090491 2.65903407054527 1 15.5952627776809 484 1503 1077 1733 373 164 600 428 2094 1113 146 281 M12752 GO_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. 109/141 Gene Ontology BP GO:0060070 3.19780254355568e-08 1.97691467186943e-07 570 676.272727272727 602 2.90709326367022e-09 49 2.24101593995331 2.6535204716254 1 16.1010579865714 570 49 877 602 475 758 1254 1123 378 940 413 282 M13913 GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/47 Gene Ontology BP GO:0051954 2.33232395239926e-08 1.97691467186943e-07 605 1233.09090909091 603 2.12029452465939e-09 31 2.68065847701734 3.4142203395408 1 19.281951262329 2697 601 659 472 199 3349 3467 31 901 585 603 283 M15342 GO_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_GROWTH.html Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 53/75 Gene Ontology BP GO:0060420 5.85432661409797e-08 2.0762333639785e-07 975 749.818181818182 604 5.32211524534996e-09 195 2.97990121296088 3.17572677354622 1 21.3785635309303 971 311 342 195 1197 492 604 1583 340 877 1336 284 M10094 GO_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell. 124/154 Gene Ontology BP GO:0016358 7.34713654262858e-08 2.26356255727441e-07 360 667.545454545455 605 6.67921526181285e-09 13 2.29526872025777 2.76890167015708 1 16.3479203035847 360 13 774 605 1415 536 578 284 1316 648 814 285 M10129 GO_SYNAPTIC_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_LOCALIZATION.html Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. 110/155 Gene Ontology BP GO:0097479 2.50286962588193e-08 1.97691467186943e-07 1195 712.363636363636 608 2.2753360494148e-09 15 2.15073364820355 -1.88563505460799 -1 15.4478492760025 1191 15 795 405 264 246 608 2428 289 704 891 286 M10269 GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 18/26 Gene Ontology BP GO:0051284 3.55309608994228e-08 1.97691467186943e-07 525 1010.81818181818 608 3.2300874066603e-09 494 2.11413526633597 2.38933542211689 1 15.1830533634786 521 877 1898 2123 601 582 494 974 608 1882 559 287 M16375 GO_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_MATURATION.html Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 22/23 Gene Ontology BP GO:0090128 1.21925705148231e-07 2.8768778197501e-07 440 748.090909090909 608 1.10841556277681e-08 100 2.69903067299639 2.41412922473188 1 18.9402718937074 440 766 1176 608 1912 466 240 100 212 1453 856 288 M12344 GO_NEPHRIC_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. 20/29 Gene Ontology BP GO:0072176 6.69063417788705e-08 2.18361447198576e-07 110 746 609 6.0823948921477e-09 97 2.84529729838702 3.17227133802407 1 20.3405239151199 107 1944 1091 830 1327 264 97 207 609 1471 259 289 M10512 GO_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 148/204 Gene Ontology BP GO:0051216 6.67581196941827e-11 1.58482413743384e-09 190 943.818181818182 612 6.06891997238259e-12 145 2.65792596564458 2.95542736835067 1 25.1299094885353 189 2187 145 1325 1769 464 612 620 2413 234 424 290 M15552 GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 89/127 Gene Ontology BP GO:0051279 4.06788693708027e-08 1.97691467186943e-07 1515 1005.36363636364 613 3.69807910208828e-09 91 2.41653835993331 2.63664333729751 1 17.3709944426468 1511 91 489 461 755 1008 2145 3124 613 330 532 291 M10360 GO_BONE_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. 34/39 Gene Ontology BP GO:0061430 1.91629328913956e-10 4.12801512702147e-09 15 974.363636363636 614 1.74208480846043e-11 13 3.65485394598139 3.97170533379939 1 32.9580527284211 13 1778 158 928 3683 627 614 1527 369 494 527 292 M13417 GO_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. 32/65 Gene Ontology BP GO:0042461 2.51211223751181e-06 3.15318539011126e-06 610 1093 614 2.28374100547271e-07 179 2.35026614332501 2.53687614706993 1 13.8407208200044 607 614 1375 1199 3677 500 449 179 1219 1606 598 293 M10490 GO_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_DEVELOPMENT.html The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 75/113 Gene Ontology BP GO:0001656 4.94780467781226e-08 2.01774734543894e-07 410 787.090909090909 616 4.49800435371683e-09 186 3.0460940915261 3.44582910642443 1 21.8967553059789 406 186 256 695 1795 456 829 2227 616 441 751 294 M10819 GO_ACTIN_MYOSIN_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_MYOSIN_FILAMENT_SLIDING.html The sliding movement of actin thin filaments and myosin thick filaments past each other. 30/58 Gene Ontology BP GO:0033275 5.56654302737596e-08 2.05617623085131e-07 620 752.272727272727 616 5.06049378929387e-09 69 3.10709932537311 3.56320179981162 1 22.310079372049 617 575 616 485 1132 1528 2069 223 69 734 227 295 M13352 GO_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULUS_DEVELOPMENT.html The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. 74/90 Gene Ontology BP GO:0032835 3.90217307034282e-14 1.71290672606652e-12 130 719.090909090909 616 3.54743006394808e-15 71 3.4178197987707 3.57722781762688 1 43.2881724026783 130 169 71 881 2832 487 667 1084 655 318 616 296 M10820 GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 424/544 Gene Ontology BP GO:0010769 2.06556029799138e-15 1.14417286506594e-13 495 652.545454545455 617 1.87778208908307e-16 54 2.37068327100793 2.74528093989577 1 32.9979587097228 491 1289 54 379 617 375 1109 976 970 159 759 297 M14866 GO_MUSCLE_FILAMENT_SLIDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_FILAMENT_SLIDING.html The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. 30/58 Gene Ontology BP GO:0030049 5.56654302737596e-08 2.05617623085131e-07 620 752.636363636364 617 5.06049378929387e-09 70 3.10709932537311 3.56320179981162 1 22.310079372049 618 576 617 486 1133 1529 2070 216 70 736 228 298 M13301 GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 19/33 Gene Ontology BP GO:0010644 3.76776884388032e-08 1.97691467186943e-07 185 568 618 3.42524446218906e-09 20 3.16870643065868 2.95231458172131 1 22.8130664823264 185 800 618 543 664 188 20 1099 593 778 760 299 M16025 GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. 32/37 Gene Ontology BP GO:0044803 4.12921066875097e-08 1.97691467186943e-07 340 1561 618 3.75382795113881e-09 127 0.97249686467329 -0.984949211863889 -1 6.92309303423807 338 618 3782 4362 764 241 160 127 3951 2548 280 300 M11323 GO_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATRIX_ADHESION.html The binding of a cell to the extracellular matrix via adhesion molecules. 145/186 Gene Ontology BP GO:0007160 3.18595515395178e-11 7.88523900603065e-10 25 753.181818181818 620 2.89632286727083e-12 23 2.5826505951341 2.85711783270673 1 25.2600083848273 23 2179 137 1284 1310 339 694 347 1202 150 620 301 M11393 GO_NEURAL_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. 193/237 Gene Ontology BP GO:0021915 2.38165143921628e-08 1.97691467186943e-07 520 794.636363636364 620 2.1651376954539e-09 219 2.18334569264684 2.47056365033285 1 15.6838033162351 519 1462 707 555 219 260 1225 1732 905 620 537 302 M10380 GO_ANTIMICROBIAL_HUMORAL_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIMICROBIAL_HUMORAL_RESPONSE.html An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. 43/176 Gene Ontology BP GO:0019730 3.07490687664686e-07 5.40315018770311e-07 110 950.090909090909 621 2.7953702785655e-08 106 2.50723165969902 -2.39712217639053 -1 16.8456282484573 106 419 621 1840 2609 206 239 1275 1707 1092 337 303 M12652 GO_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT.html The directed movement of calcium ions into a cell or organelle. 61/111 Gene Ontology BP GO:0070509 1.18392328509118e-08 1.84698312458978e-07 825 683.181818181818 621 1.07629390132948e-09 10 2.48127256297955 3.05367383153074 1 17.9184221396171 825 239 588 139 10 777 1232 629 1920 621 535 304 M13082 GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. 6/22 Gene Ontology BP GO:0010896 3.23228858965347e-08 1.97691467186943e-07 365 1088 625 3.23228863666806e-09 31 2.89325656308321 -2.89325656308321 -1 20.8201368685762 363 1116 4406 1687 603 688 625 83 31 2166 200 305 M10429 GO_SINGLE_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BEHAVIOR.html The specific behavior of a single organism in response to external or internal stimuli. 395/632 Gene Ontology BP GO:0044708 2.56745053280817e-12 7.65791495458745e-11 910 722.727272727273 626 2.33404593891924e-13 110 2.46060831711709 2.84444557124796 1 26.7503139850113 907 1313 110 441 867 315 1535 557 1074 205 626 306 M10670 GO_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_PRIMARY_GERM_LAYER.html The formation of the ectoderm, mesoderm and endoderm during gastrulation. 128/178 Gene Ontology BP GO:0001704 8.09249507943977e-09 1.32585843678286e-07 90 770.454545454545 626 7.35681373564299e-10 90 2.70541180986893 3.04110311707916 1 19.9675984779015 90 2200 210 987 736 197 543 1236 1325 626 325 307 M12810 GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPSE_MATURATION.html Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. 19/20 Gene Ontology BP GO:0090129 1.47443930327568e-07 3.23306601231938e-07 605 859.272727272727 627 1.34039945644778e-08 56 2.68357878663293 2.34604313486985 1 18.6843741561329 602 835 1265 627 2069 557 426 56 186 1665 1164 308 M10724 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 42/68 Gene Ontology BP GO:0051966 3.63009242967526e-08 1.97691467186943e-07 1340 988.454545454545 629 3.30008408143029e-09 87 3.08759123413933 3.33410714598005 1 22.2261833638428 1338 370 244 87 629 1382 2595 942 316 418 2552 309 M13784 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell migration. 83/93 Gene Ontology BP GO:0014910 3.04296432947061e-08 1.97691467186943e-07 145 693.545454545455 629 2.7663312468726e-09 98 2.59815684696451 2.88967449702259 1 18.6850370464603 141 179 629 796 421 966 1102 98 1865 828 604 310 M16254 GO_AXIS_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_ELONGATION.html The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. 35/43 Gene Ontology BP GO:0003401 2.0430199486189e-07 4.02803890717107e-07 565 1098.18181818182 629 1.85729103485731e-08 68 2.42532459992406 2.55328891942388 1 16.625484348349 563 572 1379 277 2319 447 812 3598 629 1416 68 311 M12429 GO_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 102/151 Gene Ontology BP GO:0009308 3.86036323505337e-08 1.97691467186943e-07 425 711.090909090909 630 3.50942118435599e-09 82 2.51517302120757 -2.41346430112779 -1 18.0846340574555 424 82 737 1825 692 127 315 621 630 1460 909 312 M12965 GO_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 72/83 Gene Ontology BP GO:0061383 1.1868642902479e-08 1.84698312458978e-07 75 845.181818181818 630 1.07896754240985e-09 71 2.97279271475187 3.4575384656517 1 21.4903212898336 71 1678 215 975 3422 207 350 723 894 630 132 313 M13942 GO_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_MORPHOGENESIS.html The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. 535/783 Gene Ontology BP GO:0048598 4.94143505042209e-09 8.33061496000507e-08 315 962.818181818182 630 4.94143506141008e-10 18 2.30328191806211 2.59422456678295 1 17.4845017175301 315 1247 4462 904 488 18 630 914 1394 134 85 314 M10256 GO_CARBOHYDRATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSPORT.html The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. 85/126 Gene Ontology BP GO:0008643 6.69717270843155e-08 2.18361447198576e-07 1255 666.181818181818 631 6.0883390111862e-09 125 2.31889254264639 -2.26293119280257 -1 16.5564259627952 1254 125 694 404 1329 631 1030 285 343 806 427 315 M12408 GO_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_DEVELOPMENT.html The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. 218/277 Gene Ontology BP GO:0060348 1.40010809802513e-10 3.0442537290238e-09 635 844.727272727273 631 1.27282554374022e-11 157 2.65003407126324 2.88711188233745 1 24.2441487399521 631 1441 157 716 554 366 976 1768 2019 401 263 316 M12926 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 50/63 Gene Ontology BP GO:2001240 9.06851846301852e-08 2.48403371249127e-07 25 788.909090909091 633 8.24410803347979e-09 24 3.27432913762576 3.20179445417115 1 23.2268245346695 35 1741 430 633 1629 25 24 1500 1059 1547 55 317 M12192 GO_DETECTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS.html The series of events by which a mechanical stimulus is received and converted into a molecular signal. 55/82 Gene Ontology BP GO:0050982 3.31042585170669e-08 1.97691467186943e-07 45 844.363636363636 634 3.00947809229088e-09 44 3.53700887377193 3.58175065662526 1 25.4778012747503 44 1717 241 955 2596 289 324 1322 808 634 358 318 M16493 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand. 50/63 Gene Ontology BP GO:1901099 9.06851846301852e-08 2.48403371249127e-07 40 787.363636363636 634 8.24410803347979e-09 25 3.27432913762576 3.20179445417115 1 23.2268245346695 36 1742 431 634 1630 26 25 1473 1060 1548 56 319 M10087 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 108/165 Gene Ontology BP GO:0051928 3.6464563946894e-08 1.97691467186943e-07 1400 792.272727272727 635 3.31496041375336e-09 48 2.65330402241316 2.75250818165662 1 19.084036835546 1398 48 311 93 635 828 1909 2191 708 264 330 320 M15038 GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. 46/69 Gene Ontology BP GO:0048483 8.89164982674411e-08 2.46385893090484e-07 445 920.727272727273 637 8.08331835101297e-09 263 2.82621016052861 3.51475427014461 1 20.0433659742605 443 413 637 1236 1606 263 826 344 2868 982 510 321 M16341 GO_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 87/169 Gene Ontology BP GO:0030814 2.91741133119282e-08 1.97691467186943e-07 640 1118 637 2.65219215443682e-09 176 2.43553198623983 2.56241439834365 1 17.508416764436 637 176 817 2277 392 302 821 2282 3585 619 390 322 M14063 GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of smoothened signaling. 64/92 Gene Ontology BP GO:0008589 2.90395587706591e-08 1.97691467186943e-07 640 764.545454545455 638 2.63995992308868e-09 271 2.38122632980026 2.48561079483177 1 17.1155055175903 638 271 1295 1174 388 331 729 506 1068 1720 290 323 M12968 GO_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 108/167 Gene Ontology BP GO:0090279 5.95376875826969e-08 2.09276523367486e-07 1245 825.727272727273 639 5.41251719944916e-09 32 2.45949988326081 2.58478253259006 1 17.6161794041149 1241 32 394 457 1210 639 1739 1762 635 265 709 324 M13260 GO_APPENDAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_APPENDAGE_DEVELOPMENT.html The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. 209/288 Gene Ontology BP GO:0048736 3.6669420128389e-08 1.97691467186943e-07 1005 803.363636363636 639 3.33358370359927e-09 93 2.56695727152831 3.13304229352321 1 18.4593024749736 389 2155 251 995 639 282 1005 1003 1464 561 93 325 M14599 GO_LIMB_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIMB_DEVELOPMENT.html The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. 209/288 Gene Ontology BP GO:0060173 3.6669420128389e-08 1.97691467186943e-07 390 772.181818181818 640 3.33358370359927e-09 94 2.56695727152831 3.13304229352321 1 18.4593024749736 390 2156 252 996 640 283 1006 649 1465 563 94 326 M14840 GO_STRIATED_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_CELL_PROLIFERATION.html The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. 24/29 Gene Ontology BP GO:0014855 1.89262363320985e-07 3.82885989796759e-07 645 710.363636363636 641 1.72056708729923e-08 15 2.83211295626573 3.19236651591043 1 19.5002854872913 641 711 958 935 2260 496 310 153 201 1134 15 327 M11534 GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_METANEPHROS_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. 14/17 Gene Ontology BP GO:0072202 3.54720541373771e-08 1.97691467186943e-07 485 780.818181818182 642 3.22473224630151e-09 468 2.96695884330754 3.08788759656513 1 21.3533861968582 642 931 910 920 600 1143 485 481 468 1528 481 328 M11376 GO_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_CONTRACTION.html Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. 210/333 Gene Ontology BP GO:0008016 9.74894785242823e-16 5.96866504701954e-14 645 839.181818181818 645 8.86267986584381e-17 31 2.68463142255369 2.94914480832918 1 38.2016656345219 645 1437 47 31 1242 279 1340 1922 1903 59 326 329 M12201 GO_TAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TAXIS.html The directed movement of a motile cell or organism in response to an external stimulus. 410/733 Gene Ontology BP GO:0042330 7.43553482373522e-26 2.47125310963143e-23 650 745.363636363636 646 6.75957711248655e-27 5 2.69047323090886 2.85984604569766 1 65.5298091593824 646 1297 5 348 544 313 1181 1012 1514 47 1292 330 M15330 GO_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron. 879/1295 Gene Ontology BP GO:0030182 1.89781484188742e-16 1.27978731294235e-14 495 1052.54545454545 651 1.89781484188743e-17 32 2.37276872153162 2.65853078986755 1 35.4632811949693 495 1191 4548 339 606 651 1054 447 1040 32 1175 331 M11337 GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY.html The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. 14/34 Gene Ontology BP GO:0007214 2.42255836443592e-07 4.50402143794288e-07 445 741.272727272727 652 2.20232602836282e-08 60 3.79675311762331 3.61503506931297 1 25.8917535464828 444 952 728 941 2458 402 60 286 91 1140 652 332 M10398 GO_CELL_PART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PART_MORPHOGENESIS.html The process in which the anatomical structures of a cell part are generated and organized. 711/988 Gene Ontology BP GO:0032990 3.38936544504631e-08 1.97691467186943e-07 520 1019.81818181818 655 3.3893654967414e-09 176 2.17093696191911 2.43966924604333 1 15.5940239049977 518 1214 4237 383 655 425 992 571 1167 176 880 333 M13480 GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22. 36/47 Gene Ontology BP GO:0000038 1.22504097020422e-08 1.88745550806631e-07 455 935.909090909091 657 1.11367361547791e-09 13 1.97640302701945 -1.42553803160603 -1 14.2294328195435 451 1787 1698 1502 13 385 467 527 657 2100 708 334 M14268 GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_A2_ACTIVITY.html Any process that modulates the activity of the enzyme phospholipase A2. 24/30 Gene Ontology BP GO:0032429 3.27288725718702e-08 1.97691467186943e-07 3665 1390.18181818182 657 2.9753520962518e-09 190 3.60406758704867 3.10337541947533 1 25.962983194515 3661 657 381 209 507 2799 1451 1950 190 569 2918 335 M13877 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS.html The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. 73/110 Gene Ontology BP GO:0017156 4.88617530478277e-08 2.00488304172436e-07 1115 802.181818181818 658 4.44197764845834e-09 161 2.27338121272397 -2.18838181841036 -1 16.3202574686986 1115 161 730 439 988 605 1116 2103 323 586 658 336 M10188 GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 29/42 Gene Ontology BP GO:0052646 4.3227593586511e-08 1.97691467186943e-07 40 815.636363636364 659 3.92978131235326e-09 35 2.13795264681399 -2.27372266642197 -1 15.3553764191926 37 659 1714 2482 826 58 61 35 1056 1827 217 337 M15518 GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 51/58 Gene Ontology BP GO:0061001 2.19855581667546e-08 1.97691467186943e-07 770 723.090909090909 659 1.99868712604236e-09 168 2.33719599386063 2.68578464396809 1 16.7969380731046 766 347 901 211 168 1117 659 362 513 899 2011 338 M13575 GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. 106/151 Gene Ontology BP GO:1901343 3.29529698684301e-12 9.70444106315224e-11 120 780.818181818182 660 2.99572453349814e-13 111 3.00471293012501 3.17893734949957 1 32.3569618708314 116 1611 111 699 1835 310 492 877 1358 520 660 339 M12097 GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 29/35 Gene Ontology BP GO:0050650 8.9355642411132e-08 2.47114530749848e-07 665 879.272727272727 661 8.12324054912902e-09 231 3.34509654812789 3.69408673049284 1 23.7394215539571 231 661 662 414 1611 482 251 564 2698 994 1104 340 M12492 GO_ARTERY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARTERY_MORPHOGENESIS.html The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. 76/97 Gene Ontology BP GO:0048844 3.54471188290088e-10 7.17110625701642e-09 120 946.636363636364 661 3.22246534861091e-11 117 3.25789480916074 3.61507556620818 1 28.5228457512037 117 2236 170 1341 3117 319 661 865 812 412 363 341 M13531 GO_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SIZE.html Any process that modulates the size of a cell. 209/258 Gene Ontology BP GO:0008361 3.04715677983095e-08 1.97691467186943e-07 605 818.363636363636 661 2.7701425654875e-09 426 2.34039516999046 2.60985717229994 1 16.8200846910531 604 1455 463 532 426 661 1247 692 1616 562 744 342 M15224 GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. 41/42 Gene Ontology BP GO:0061298 2.07480623887879e-07 4.07001409338238e-07 10 1095.81818181818 664 1.88618766777499e-08 6 3.67365639877689 3.74020858334814 1 25.223101203683 6 2303 306 1407 3795 266 276 1471 1098 664 462 343 M13949 GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY.html The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. 16/43 Gene Ontology BP GO:0060397 1.51841551166592e-07 3.2861336631542e-07 255 959.727272727273 665 1.38037783315025e-08 104 1.85948597632553 -1.98525722998188 -1 12.897720862004 253 927 2426 295 2096 665 360 202 104 2402 827 344 M14490 GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 37/45 Gene Ontology BP GO:0035412 9.35305133037168e-08 2.50783780632741e-07 1085 831.454545454545 665 8.50277429818738e-09 136 2.54610981727021 2.44722827316689 1 18.0245836510025 1084 439 480 509 1669 747 665 929 136 449 2039 345 M13138 GO_POSITIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of exocytosis. 82/117 Gene Ontology BP GO:0045921 1.94898129317613e-08 1.97691467186943e-07 655 671.363636363636 666 1.77180119131106e-09 113 2.28636178217422 -2.03316400765515 -1 16.4291433569436 654 151 1098 125 113 272 692 666 1006 1619 989 346 M15050 GO_RESPONSE_TO_RETINOIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RETINOIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. 137/182 Gene Ontology BP GO:0032526 2.85307280641819e-08 1.97691467186943e-07 670 1072 666 2.59370258492573e-09 310 2.807119797294 3.35766784887224 1 20.1969217881517 666 1586 310 1020 374 625 2008 2156 2058 570 419 347 M11062 GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. 30/37 Gene Ontology BP GO:0035025 2.22248251153711e-07 4.25389186597374e-07 670 1061.81818181818 668 2.02043885096056e-08 43 3.46287784569705 3.88875709036778 1 23.6976996750319 43 1807 309 968 3959 578 668 1655 434 590 669 348 M12054 GO_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_PRECURSOR_CELL_PROLIFERATION.html The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. 87/155 Gene Ontology BP GO:0061351 8.76944553585035e-08 2.45512816355666e-07 670 822.363636363636 668 7.97222353219115e-09 122 2.18827125304583 2.66882260373364 1 15.4972417441603 668 153 1593 1163 1590 237 672 483 395 1970 122 349 M15911 GO_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. 339/435 Gene Ontology BP GO:0001525 2.57334914161134e-17 1.931257025148e-15 255 782.545454545455 668 2.33940831055576e-18 36 2.60447026170443 2.72205030792109 1 41.2458499444249 255 1339 36 1098 1471 362 610 668 1937 90 742 350 M13868 GO_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 46/71 Gene Ontology BP GO:0098900 3.03952957635164e-08 1.97691467186943e-07 3310 1662.54545454545 669 2.76320874395083e-09 153 2.71255325160519 3.46072454558128 1 19.5127157254217 3308 392 669 153 418 4187 4489 446 1269 424 2533 351 M14023 GO_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. 140/211 Gene Ontology BP GO:0042471 1.35576224046009e-07 3.06082566951033e-07 435 851.454545454545 669 1.23251120364518e-08 111 2.53333807740431 2.88941686840428 1 17.6969987421661 433 1572 291 1391 2039 277 669 722 1565 296 111 352 M14692 GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_ALVEOLUS_DEVELOPMENT.html The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. 19/24 Gene Ontology BP GO:0060749 2.13184629457752e-08 1.97691467186943e-07 1750 916.909090909091 670 1.9380421047596e-09 152 3.39497621741401 -4.4467260466117 -1 24.450169315923 1747 846 670 507 152 2011 2067 161 561 781 583 353 M11315 GO_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGENERATION.html The regrowth of a lost or destroyed body part, such as an organ or tissue. 177/245 Gene Ontology BP GO:0031099 3.7904116214847e-08 1.97691467186943e-07 945 733.090909090909 671 3.44582880617296e-09 104 2.33725991201525 2.53699476956654 1 16.7974005325144 944 1507 413 104 671 231 552 1278 896 443 1025 354 M15053 GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT.html The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. 19/24 Gene Ontology BP GO:0061377 2.13184629457752e-08 1.97691467186943e-07 1750 911.818181818182 671 1.9380421047596e-09 95 3.39497621741401 -4.4467260466117 -1 24.450169315923 1748 847 671 508 153 2012 2068 95 562 782 584 355 M11646 GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM.html The process in which the anatomical structures of embryonic epithelia are generated and organized. 165/203 Gene Ontology BP GO:0016331 2.63509268370481e-08 1.97691467186943e-07 675 876.818181818182 672 2.39553883206104e-09 228 2.15249669199235 2.42570862041307 1 15.4606052167041 671 1514 672 965 298 228 1178 1814 1216 487 602 356 M14392 GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoblast differentiation. 136/162 Gene Ontology BP GO:0045667 4.5557282842193e-08 1.97760774550163e-07 675 700.181818181818 672 4.14157125323514e-09 126 2.56934401217577 2.77599177250464 1 18.4761488546968 672 1576 362 216 913 126 806 1184 1009 662 176 357 M10443 GO_LYSOSOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOMAL_TRANSPORT.html The directed movement of substances into, out of or within a lysosome. 93/101 Gene Ontology BP GO:0007041 3.37048281990436e-08 1.97691467186943e-07 335 1482.90909090909 673 3.06407533776494e-09 111 1.17034696103273 -1.1942100963882 -1 8.35457426742477 334 111 3867 2370 537 194 673 633 3340 3458 795 358 M12655 GO_BEHAVIORAL_RESPONSE_TO_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_PAIN.html Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. 16/32 Gene Ontology BP GO:0048266 5.93757532071118e-08 2.08982889313685e-07 470 823.909090909091 674 5.39779589178207e-09 32 4.3959325488659 5.25939095986844 1 31.5778253168995 468 899 674 578 1209 1374 2334 32 60 1154 281 359 M10632 GO_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 70/93 Gene Ontology BP GO:0061035 3.80548186634261e-08 1.97691467186943e-07 820 892.636363636364 675 3.45952902924407e-09 416 2.59288766501666 3.12043522687544 1 18.6469135620073 818 2255 664 766 675 434 1389 537 1310 555 416 360 M12305 GO_HEMIDESMOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMIDESMOSOME_ASSEMBLY.html Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina. 23/25 Gene Ontology BP GO:0031581 1.30657713455075e-08 1.93614758186772e-07 160 967.818181818182 675 1.18779740210045e-09 158 3.69637016139249 3.93367126072847 1 26.6669095000054 158 675 219 1278 2181 460 849 1425 2716 377 308 361 M14199 GO_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSSIFICATION.html The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. 327/459 Gene Ontology BP GO:0001503 3.06840999621331e-15 1.66015252469541e-13 305 760.545454545455 675 2.7894636329212e-16 56 2.62466799041996 2.87310496413972 1 36.0874219267756 301 1348 56 717 1244 291 565 675 2110 332 727 362 M13402 GO_AMINOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 151/196 Gene Ontology BP GO:0006022 9.26736860674461e-10 1.76725680849109e-08 395 738.727272727273 676 8.42488055513492e-11 180 2.59076808394596 2.89505330802561 1 21.5637507345243 394 1538 180 343 995 638 1036 676 1002 222 1102 363 M14928 GO_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. 84/111 Gene Ontology BP GO:0030510 3.81289733889951e-08 1.97691467186943e-07 815 738.818181818182 677 3.4662703681656e-09 166 2.5225219470028 2.51991431116286 1 18.1378048648169 811 166 732 1130 677 490 1286 1052 670 675 438 364 M12556 GO_MESENCHYMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. 148/195 Gene Ontology BP GO:0048762 4.40026522312685e-13 1.51662474690439e-11 680 874.727272727273 678 4.00024111193429e-14 93 2.76112611020191 3.15549206690062 1 32.1267410041954 678 1552 93 526 1664 675 572 912 1745 213 992 365 M12847 GO_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_VACUOLE.html A process in which a protein is transported to, or maintained at, a location in a vacuole. 59/61 Gene Ontology BP GO:0072665 2.57197800979156e-08 1.97691467186943e-07 680 1988.54545454545 679 2.33816185441824e-09 148 1.02738707694665 -0.923137300254669 -1 7.32023364827248 679 2688 3963 4426 281 148 266 614 4317 4273 219 366 M13192 GO_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_RATE.html Any process that modulates the frequency or rate of heart contraction. 104/161 Gene Ontology BP GO:0002027 6.16449519111766e-14 2.60758146584277e-12 465 722.727272727273 681 5.60408653737982e-15 74 3.15817780788123 3.56591577822905 1 39.3690539843001 464 1610 74 681 1382 153 811 754 1812 130 79 367 M10937 GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that activates or increases the activity of a transporter. 89/118 Gene Ontology BP GO:0032411 5.9248234221335e-08 2.08691925686504e-07 860 789.818181818182 682 5.38620325608636e-09 103 2.55988157882934 2.79705686733871 1 18.3431360356349 857 103 441 456 1208 682 1272 2008 726 489 446 368 M12779 GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the cytosol. 53/99 Gene Ontology BP GO:0060401 1.50648503343385e-08 1.97691467186943e-07 1080 676.272727272727 683 1.36953185795431e-09 35 2.87351012283823 3.56779984183415 1 20.6772678017773 1077 276 290 70 35 1279 1658 683 946 395 730 369 M16262 GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of cation channel activity. 82/127 Gene Ontology BP GO:2001257 2.39037039312156e-08 1.97691467186943e-07 1205 689.636363636364 683 2.17306401735791e-09 111 2.35117693558976 2.5731449707989 1 16.8980927153099 1201 144 777 111 224 901 1545 627 810 683 563 370 M10250 GO_FATTY_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 76/95 Gene Ontology BP GO:0009062 2.2051931290619e-08 1.97691467186943e-07 350 1264.36363636364 684 2.00472104651444e-09 174 1.54614066323574 -1.31308547014437 -1 11.0735096743405 348 194 3143 2721 174 684 846 371 555 3465 1407 371 M13905 GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a neurophysiological process. 27/34 Gene Ontology BP GO:0031646 3.49897593122064e-08 1.97691467186943e-07 685 1150.72727272727 684 3.18088726079081e-09 297 3.54827399269533 4.06918548236709 1 25.5593064477332 1575 681 606 577 587 2207 2348 297 684 1012 2084 372 M16461 GO_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIOR.html The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 512/825 Gene Ontology BP GO:0007610 8.99806266417758e-11 2.02260799886079e-09 685 1061.63636363636 684 8.99806266454191e-12 97 2.48335565380683 2.80008857369847 1 23.1880639248454 684 1254 4625 378 530 178 1324 826 1194 97 588 373 M10903 GO_PHOSPHOLIPID_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_DEPHOSPHORYLATION.html The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 29/34 Gene Ontology BP GO:0046839 4.52057969527096e-08 1.97760774550163e-07 685 1073.72727272727 685 4.10961798923659e-09 105 1.45358454170463 -1.49410770834247 -1 10.4036105829052 685 616 2770 1133 901 455 554 1243 105 3146 203 374 M14412 GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). 80/201 Gene Ontology BP GO:0007188 3.49389176202631e-08 1.97691467186943e-07 460 1090.09090909091 686 3.17626528864903e-09 233 2.45117339075491 2.51434446278407 1 17.6215851552329 459 2245 829 2712 584 233 788 599 2590 686 266 375 M10101 GO_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 723/1049 Gene Ontology BP GO:0048666 8.50720847500529e-16 5.27787213789328e-14 515 1046 689 8.50720847500533e-17 36 2.32499193047024 2.63894710366353 1 33.2029680480483 511 1213 4223 356 657 616 1071 689 1090 36 1044 376 M14078 GO_CELLULAR_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 65/74 Gene Ontology BP GO:0031670 8.14494453369593e-12 2.24251046836019e-10 340 731.727272727273 690 7.40449503066009e-13 121 3.09841903111398 3.39798940327698 1 32.1531908784437 339 217 121 962 2376 417 693 1101 878 255 690 377 M11165 GO_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of exocytosis. 164/250 Gene Ontology BP GO:0017157 3.20087600498857e-08 1.97691467186943e-07 515 710.090909090909 694 2.90988731959956e-09 101 2.14318871447415 -1.95641623554998 -1 15.3932603157846 515 1515 772 694 478 101 685 777 820 790 664 378 M15288 GO_LOCOMOTORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_BEHAVIOR.html The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. 194/330 Gene Ontology BP GO:0007626 8.70229306608246e-11 1.97520827495033e-09 875 639.636363636364 694 7.91117551493336e-12 47 2.60308055282968 2.96331526673007 1 24.340367481121 874 1461 152 47 694 359 899 1036 760 277 477 379 M11108 GO_NEGATIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LOCOMOTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. 318/444 Gene Ontology BP GO:0040013 1.24501567574216e-13 4.90937113493922e-12 240 684.181818181818 697 1.13183243249294e-14 81 2.49424470238282 2.75227049924317 1 30.3291611404322 240 1345 81 906 293 697 987 499 1171 208 1099 380 M12831 GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL.html Any process that modulates the potential difference across a post-synaptic membrane. 35/76 Gene Ontology BP GO:0060078 9.84496711494175e-08 2.57032100060153e-07 500 813.181818181818 699 8.94997050500233e-09 312 2.97329948071235 3.64736234291553 1 21.0334515147135 500 523 630 734 1716 891 1483 312 699 669 788 381 M13035 GO_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_GROWTH.html Any process that modulates the frequency, rate, extent or direction of cell growth. 432/558 Gene Ontology BP GO:0001558 2.99160028904675e-08 1.97691467186943e-07 730 903.454545454545 699 2.71963666338826e-09 351 2.33967295208317 2.58775001885156 1 16.8148593138631 726 1307 351 1298 405 600 1366 699 2046 460 680 382 M10744 GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 18/29 Gene Ontology BP GO:0072207 8.76246944031799e-08 2.45512816355666e-07 640 936.818181818182 705 7.96588162665634e-09 525 3.01082878268593 2.90090025274488 1 21.3650710715092 636 816 559 705 1588 647 525 2621 740 677 791 383 M15453 GO_REGULATION_OF_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_SPECIFICATION.html Any process that mediates the adoption of a specific fate by a cell. 14/24 Gene Ontology BP GO:0042659 1.58187520522195e-07 3.37466835750567e-07 475 797.363636363636 707 1.43806847178563e-08 56 2.62093165189759 2.83205472636043 1 18.1928957058728 471 949 1370 1061 2129 371 56 707 553 847 257 384 M12635 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_VIRUS.html Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. 58/80 Gene Ontology BP GO:0050690 5.75708042799301e-08 2.07580109259326e-07 200 1403.36363636364 708 5.23370961695222e-09 120 1.32177210807213 -1.28207873065599 -1 9.4199239578561 200 310 3261 2388 1175 180 120 708 3781 2847 467 385 M16608 GO_POSITIVE_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELINATION.html Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 13/16 Gene Ontology BP GO:0031643 1.24224936937475e-08 1.89604759999972e-07 810 601.727272727273 709 1.12931761489929e-09 14 4.25836093335312 4.94406822045167 1 30.7802749079451 810 944 631 462 14 831 709 115 23 1337 743 386 M14465 GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. 7/18 Gene Ontology BP GO:0033604 5.64253739062383e-07 8.727482578952e-07 650 1281.45454545455 710 5.64253882334461e-08 85 2.90446011928473 2.91175160050472 1 18.8796995494571 648 1114 4496 1365 3030 710 85 628 119 1215 686 387 M10805 GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PLATELET_ACTIVATION.html Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 24/28 Gene Ontology BP GO:0010544 5.37192202996899e-08 2.05087954115883e-07 345 723.727272727273 711 4.88356560103605e-09 345 3.84289571040061 4.06190218536345 1 27.6247880081614 345 746 396 991 1094 720 627 378 1385 568 711 388 M15954 GO_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 1400/2148 Gene Ontology BP GO:0048468 6.85147325608328e-28 3.0221171592833e-25 585 1088.72727272727 713 6.85147325608329e-29 7 2.34830825648352 2.63250313268489 1 62.0288215257971 584 1149 4583 327 529 713 1129 397 1348 7 1210 389 M13541 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 101/147 Gene Ontology BP GO:0010522 3.67814969805842e-08 1.97691467186943e-07 1650 1078.18181818182 716 3.34377250868444e-09 65 2.44162683278142 2.61790576302422 1 17.5525140815664 1646 65 446 470 644 1110 2315 3437 716 283 728 390 M10455 GO_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ORGAN_DEVELOPMENT.html The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. 278/408 Gene Ontology BP GO:0007517 6.02443657551677e-14 2.58846873414092e-12 920 764.545454545455 718 5.47676052319721e-15 72 2.66799335242328 3.18837216404722 1 33.250182762065 917 1369 72 1277 718 543 1746 490 738 141 399 391 M12808 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. 74/90 Gene Ontology BP GO:0010633 1.06591616144633e-07 2.66364548829741e-07 810 897.545454545455 718 9.69014739173418e-09 159 2.41758564174548 2.62803937062724 1 17.0407188036662 527 215 808 807 1791 351 718 159 1735 2389 373 392 M10212 GO_VIRAL_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_BUDDING.html A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. 25/25 Gene Ontology BP GO:0046755 4.45467107928395e-08 1.97691467186943e-07 120 1393.72727272727 720 4.04970106316763e-09 29 0.960155115084759 -0.952791807969767 -1 6.83379824365796 119 720 3677 3871 872 98 29 59 3162 2644 80 393 M14603 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_VACUOLE.html The directed movement of a protein to a specific location in a vacuole. 42/44 Gene Ontology BP GO:0072666 3.49985797441649e-08 1.97691467186943e-07 535 1948.18181818182 720 3.18168911826708e-09 142 0.914466274386053 -0.90754598223646 -1 6.50323121725917 531 2316 3912 4016 588 142 146 720 4396 4291 372 394 M13432 GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_ORGANELLE_ORGANIZATION.html An organelle organization which involves another organism. 25/25 Gene Ontology BP GO:1902590 4.45467107928395e-08 1.97691467186943e-07 120 1398 721 4.04970106316763e-09 30 0.960155115084759 -0.952791807969767 -1 6.83379824365796 120 721 3678 3872 873 99 30 94 3163 2647 81 395 M16627 GO_NEPHRIC_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRIC_DUCT_MORPHOGENESIS.html The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. 17/25 Gene Ontology BP GO:0072178 8.76116053414619e-08 2.45512816355666e-07 305 976 721 7.9646917118599e-09 145 2.92045507957265 3.36055288733794 1 20.7203776045596 303 2001 1334 1248 1587 462 145 395 721 2132 408 396 M15650 GO_MULTI_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves another organism. 25/25 Gene Ontology BP GO:1902592 4.45467107928395e-08 1.97691467186943e-07 125 1402.45454545455 722 4.04970106316763e-09 31 0.960155115084759 -0.952791807969767 -1 6.83379824365796 121 722 3679 3873 874 100 31 130 3164 2651 82 397 M13025 GO_CELL_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGGREGATION.html The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. 35/45 Gene Ontology BP GO:0098743 7.60662336447519e-09 1.25065789805311e-07 135 930.727272727273 723 6.9151121734323e-10 135 3.19249684866758 3.49292732546949 1 23.6703187337607 135 484 208 958 3414 677 985 1457 752 445 723 398 M14345 GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. 26/42 Gene Ontology BP GO:0055083 4.85868613242542e-08 1.99712602245367e-07 1855 880.090909090909 724 4.41698749066291e-09 90 3.10448321703889 3.5558099155148 1 22.3335991219976 1854 647 584 90 984 1763 1220 802 390 724 623 399 M16745 GO_CARTILAGE_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_CONDENSATION.html The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. 35/45 Gene Ontology BP GO:0001502 7.60662336447519e-09 1.25065789805311e-07 140 931.363636363636 724 6.9151121734323e-10 136 3.19249684866758 3.49292732546949 1 23.6703187337607 136 485 209 959 3415 678 986 1454 753 446 724 400 M10559 GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cation channel activity. 39/56 Gene Ontology BP GO:2001259 3.95564907837336e-08 1.97691467186943e-07 735 586.272727272727 726 3.59604468136075e-09 89 2.50075714843981 2.69730528448656 1 17.9803326105178 733 458 830 89 726 811 1233 225 194 800 350 401 M16467 GO_DERMATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. 12/14 Gene Ontology BP GO:0030205 1.57128648222289e-06 2.07409815653421e-06 145 1083.81818181818 726 1.42844327679092e-07 143 3.17578893941223 3.17578893941223 1 19.3654663303155 143 2031 1192 1110 3492 395 192 534 549 1558 726 402 M10676 GO_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 31/35 Gene Ontology BP GO:0051125 7.64048919197012e-08 2.29998364753442e-07 730 1235.63636363636 727 6.94589950665498e-09 180 1.72117072461599 -1.81482270967276 -1 12.2177749403541 727 621 2647 1765 1453 383 180 1226 497 3589 504 403 M11506 GO_TOOTH_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOOTH_MINERALIZATION.html The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. 28/32 Gene Ontology BP GO:0034505 1.63169033602522e-08 1.97691467186943e-07 70 1131.63636363636 728 1.48335486193373e-09 69 3.4227339789516 3.44668400580511 1 24.6510017413172 69 1833 228 988 3676 676 716 2076 639 728 819 404 M16087 GO_SOMITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITE_DEVELOPMENT.html The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 86/123 Gene Ontology BP GO:0061053 3.96294861541661e-08 1.97691467186943e-07 650 795.454545454545 728 3.60268062436617e-09 140 2.33788825862491 2.86439535147782 1 16.8019467338871 650 140 820 1379 728 236 450 1328 1639 852 528 405 M14605 GO_REGULATION_OF_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMINO_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 23/46 Gene Ontology BP GO:0051955 3.2981019348757e-08 1.97691467186943e-07 1045 805.090909090909 731 2.99827453119889e-09 476 3.16254459407181 3.32382494872315 1 22.7684844801015 1045 731 644 476 516 877 1243 1155 546 1027 596 406 M15212 GO_MEMBRANE_PROTEIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. 44/63 Gene Ontology BP GO:0033619 1.55618572830856e-08 1.97691467186943e-07 1695 1117.72727272727 731 1.41471430846941e-09 41 2.26346889598487 -1.75380944892387 -1 16.2635091846256 1694 432 1824 1011 41 731 605 2443 295 2753 466 407 M15963 GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. 14/24 Gene Ontology BP GO:0036152 1.62130018556716e-07 3.43529588499272e-07 205 1022 732 1.47390936822695e-08 36 2.59383676207463 -2.53780819274961 -1 17.9820029375499 201 2003 1619 1494 2149 143 89 36 732 2492 284 408 M14110 GO_BLOOD_VESSEL_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_VESSEL_REMODELING.html The reorganization or renovation of existing blood vessels. 34/45 Gene Ontology BP GO:0001974 7.66309300751025e-07 1.12197519710337e-06 705 1369.90909090909 733 6.96645061521687e-08 91 3.24110379996399 3.65056111145394 1 20.6994733299391 702 2742 733 1933 3284 476 212 91 2654 1583 659 409 M12371 GO_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BEHAVIOR.html Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 48/91 Gene Ontology BP GO:0050795 1.22253028194141e-07 2.88167782170068e-07 1910 1020.72727272727 734 1.1113912271608e-08 181 3.00494683751558 3.49699270726108 1 21.097489498031 1906 391 484 181 1913 1904 2079 296 911 429 734 410 M16346 GO_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGIONALIZATION.html The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 257/438 Gene Ontology BP GO:0003002 4.10402079634911e-08 1.97691467186943e-07 735 991.545454545455 735 3.73092806628014e-09 55 2.16470332049526 2.37946072020701 1 15.5489223817897 735 1407 695 1368 760 55 671 1941 2125 603 547 411 M12496 GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that activates or increases the frequency, rate or extent of regulated secretory pathway. 46/74 Gene Ontology BP GO:1903307 3.40181917058505e-08 1.97691467186943e-07 1190 925.181818181818 736 3.09256293016977e-09 428 2.42009482904422 -2.12283106001795 -1 17.3967261399386 1188 428 1147 719 547 662 714 736 1619 1182 1235 412 M16730 GO_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. 376/476 Gene Ontology BP GO:0048589 2.82840950854039e-08 1.97691467186943e-07 520 871.545454545455 739 2.57128140445779e-09 359 2.23571663341911 2.48774906933211 1 16.0627165452873 739 1328 391 933 366 518 1356 1271 1807 359 519 413 M15506 GO_CEREBRAL_CORTEX_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_CELL_MIGRATION.html The orderly movement of cells from one site to another in the cerebral cortex. 51/66 Gene Ontology BP GO:0021795 5.54526870563484e-08 2.05617623085131e-07 710 762.636363636364 740 5.04115349582509e-09 133 2.5213885407918 2.9875297363102 1 18.0831476748255 709 336 740 251 1129 744 658 133 1144 898 1647 414 M16358 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE.html Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. 24/40 Gene Ontology BP GO:0043576 1.95664636757928e-07 3.91918878534067e-07 210 1124.09090909091 740 1.77876958327312e-08 206 1.99402081120483 2.09595349805499 1 13.6744083998923 206 740 1389 2484 2284 307 418 484 2311 1424 318 415 M16278 GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RYANODINE_SENSITIVE_CALCIUM_RELEASE_CHANNEL_ACTIVITY.html Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. 15/19 Gene Ontology BP GO:0060315 3.39530550365751e-08 1.97691467186943e-07 2200 1199.72727272727 743 3.08664141459814e-09 352 2.05776171990824 2.20311719732575 1 14.7751805585401 688 2011 2200 2547 543 743 662 352 768 2199 484 416 M16085 GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. 23/36 Gene Ontology BP GO:0048486 4.40114501477377e-08 1.97691467186943e-07 520 985.545454545455 744 4.00104100256326e-09 12 2.6292526587122 3.06986203451551 1 18.9100208688926 516 744 850 1899 1660 382 436 12 3223 812 307 417 M11475 GO_NEURON_PROJECTION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). 604/850 Gene Ontology BP GO:0031175 1.7111147892161e-14 8.04223950931569e-13 460 1024.63636363636 746 1.71111478921611e-15 51 2.34875330312006 2.67103170878607 1 30.544939324442 458 1228 4306 362 668 746 984 355 1029 51 1084 418 M12969 GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. 28/34 Gene Ontology BP GO:0030201 5.01336058672188e-08 2.02375063519002e-07 755 746.636363636364 753 4.55760063724215e-09 68 2.63534187503727 2.57230533024607 1 18.9251551419249 753 648 998 891 1013 724 376 120 68 1676 946 419 M13053 GO_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DIFFERENTIATION.html The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. 75/95 Gene Ontology BP GO:0002062 6.01333047777638e-08 2.09491454642436e-07 1325 974.727272727273 753 5.4666642201279e-09 238 2.73703774134215 3.22999662935007 1 19.6154910657532 238 1674 262 1323 1324 728 670 1078 2230 442 753 420 M14056 GO_BLASTODERM_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTODERM_SEGMENTATION.html The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. 20/27 Gene Ontology BP GO:0007350 3.02224641862838e-07 5.33479233151663e-07 525 1129.18181818182 754 2.7474971216446e-08 91 3.2776384370936 3.41497482740665 1 22.0761613556955 524 1940 589 1144 2597 325 91 1370 2561 526 754 421 M11055 GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. 25/34 Gene Ontology BP GO:0002042 9.17989368352913e-08 2.49206886189644e-07 50 644 757 8.34535824234238e-09 6 2.83020890912472 3.0704541741326 1 20.0567831390211 46 757 810 834 2161 48 6 22 1361 1015 24 422 M12853 GO_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_GROWTH.html Any process that modulates the frequency, rate or extent of growth of an organ of an organism. 77/110 Gene Ontology BP GO:0046620 4.08979294876978e-08 1.97691467186943e-07 880 792.272727272727 758 3.7179936589081e-09 173 2.67417872811358 2.78401336406294 1 19.2350691069893 876 173 572 214 758 504 794 1400 337 1598 1489 423 M15566 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 53/65 Gene Ontology BP GO:0010596 3.98870829694863e-08 1.97691467186943e-07 815 923.909090909091 764 3.62609851751443e-09 309 2.31694734315397 2.62952925185541 1 16.6504354227784 815 358 1172 1419 733 556 946 309 764 2615 476 424 M14290 GO_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. 44/63 Gene Ontology BP GO:0006939 3.67858822463467e-07 6.24090805343792e-07 3215 1607.09090909091 768 3.3441716724784e-08 428 3.45719361495486 4.63683049538034 1 23.0375288964436 3213 451 428 743 2709 3908 3325 475 944 714 768 425 M15367 GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLSERINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. 22/33 Gene Ontology BP GO:0006658 9.85608993145921e-08 2.57032100060153e-07 10 780.363636363636 768 8.96008215728736e-09 7 2.32903727087974 -2.32903727087974 -1 16.4513626252942 7 768 1473 2064 1717 19 11 55 845 1452 173 426 M12739 GO_REGULATION_OF_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of neuron differentiation. 614/801 Gene Ontology BP GO:0045664 1.01013225321514e-12 3.31312992386011e-11 375 890.363636363636 770 1.0101322532156e-13 35 2.42169596865406 2.76268915050156 1 27.2764981647937 373 1225 4385 340 772 35 800 770 861 67 166 427 M14182 GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in an epithelial cell. 47/55 Gene Ontology BP GO:1904019 1.17732282950786e-07 2.82410554926575e-07 355 955.090909090909 770 1.0702935386472e-08 351 3.11467750131879 3.28203736859437 1 21.9014910919584 480 356 352 971 1879 718 1174 2256 351 770 1199 428 M11392 GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_MEDIATED_SIGNALING_USING_INTRACELLULAR_CALCIUM_SOURCE.html A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. 22/27 Gene Ontology BP GO:0035584 4.14789133762993e-08 1.97691467186943e-07 335 1054.63636363636 771 3.77081037803135e-09 121 2.89361844906967 3.54675209940802 1 20.8227551791441 332 1915 1156 1353 771 630 440 121 2250 2175 458 429 M14978 GO_REGULATION_OF_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUTAMATE_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of glutamate. 10/26 Gene Ontology BP GO:0014048 2.75805042520473e-08 1.97691467186943e-07 1045 741.454545454545 771 2.50731859980116e-09 57 3.51691900864774 3.44441590804378 1 25.3324474668336 1030 1043 771 896 342 1041 1301 57 686 746 243 430 M14608 GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROPHILIC_CELL_CELL_ADHESION_VIA_PLASMA_MEMBRANE_CELL_ADHESION_MOLECULES.html The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. 55/84 Gene Ontology BP GO:0007157 2.64086089451027e-14 1.18153132136118e-12 925 823.181818181818 772 2.40078263137299e-15 69 3.42883827202199 3.72513565094758 1 44.0249404109211 924 248 69 338 1522 1221 1956 288 772 124 1593 431 M10164 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 19/24 Gene Ontology BP GO:0051968 3.54662705332816e-08 1.97691467186943e-07 780 712.636363636364 774 3.22420646409405e-09 112 3.73374606494427 3.73698829358155 1 26.9012304376122 774 780 404 142 599 1030 1111 112 258 777 1852 432 M10696 GO_SALIVARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SALIVARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. 48/55 Gene Ontology BP GO:0007431 4.16388821939734e-08 1.97691467186943e-07 1095 857.363636363636 775 3.78535299836934e-09 344 2.80922349054235 3.19034626570874 1 20.2121423893078 1093 344 444 765 775 956 664 1126 1761 428 1075 433 M10699 GO_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_CONDENSATION.html The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. 30/40 Gene Ontology BP GO:0030261 5.71411675345956e-07 8.81315312055523e-07 250 1425.18181818182 776 5.1946529432749e-08 246 1.82980392962314 2.00122348954466 1 11.8439480279058 246 679 2670 2764 2978 607 573 441 2011 1932 776 434 M16413 GO_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized. 194/279 Gene Ontology BP GO:0048705 1.65307830266214e-09 2.98130749701045e-08 300 833.909090909091 776 1.50279845809479e-10 192 2.60356785925468 2.89363918115297 1 21.0327084671161 300 2162 192 964 1537 268 776 983 1395 305 291 435 M10733 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. 40/59 Gene Ontology BP GO:0050974 1.49157883272511e-08 1.97691467186943e-07 55 1089.27272727273 778 1.35598076621625e-09 54 4.17151558398302 4.06204042450955 1 30.0685720891759 54 1775 226 950 3636 640 697 1708 778 875 643 436 M12114 GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of epithelial cell proliferation. 327/422 Gene Ontology BP GO:0050678 3.83741575091966e-13 1.34095524523612e-11 575 753.090909090909 779 3.48855977356394e-14 91 2.54487094923912 2.78301462319944 1 29.7485116243282 571 1344 91 560 920 441 779 1183 1440 172 783 437 M15295 GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_DEPENDENT_CELL_MIGRATION.html The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. 55/73 Gene Ontology BP GO:0006929 8.99596943973984e-08 2.4768192782905e-07 290 934.090909090909 779 8.17815437053814e-09 93 3.16196894332365 3.79934292095099 1 22.4302143209512 290 2280 500 790 1620 347 194 93 2204 1178 779 438 M10074 GO_FOREBRAIN_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. 48/71 Gene Ontology BP GO:0021884 1.19546098386444e-06 1.63698645024168e-06 570 1246.63636363636 780 1.08678330315282e-07 176 2.86416058728906 3.46416464110558 1 17.7718228303005 569 2290 619 1591 3363 780 515 176 2074 427 1309 439 M13117 GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 41/45 Gene Ontology BP GO:0010837 1.53494146124814e-07 3.31158121836001e-07 755 908.363636363636 780 1.39540142576466e-08 126 2.88170735987465 3.32122407248991 1 20.0397820478018 754 470 780 998 2103 1183 701 126 603 942 1332 440 M13795 GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROITIN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. 12/15 Gene Ontology BP GO:0030207 2.11509784671926e-05 2.34601913725499e-05 195 1375.81818181818 780 1.92283471065022e-06 193 2.93751579853785 2.93751579853785 1 14.5641528086198 193 2035 1667 1492 4174 762 544 462 466 2559 780 441 M16921 GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 410/508 Gene Ontology BP GO:0031346 4.4870797326762e-08 1.97691467186943e-07 610 817.090909090909 780 4.07916347653986e-09 335 2.21122652633336 2.58070581111812 1 15.8855261908874 919 1306 335 484 887 610 1612 606 780 410 1039 442 M12346 GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. 118/127 Gene Ontology BP GO:0006892 4.1798293215936e-08 1.97691467186943e-07 230 1402 781 3.79984491000647e-09 159 1.3398859487343 -1.36238983285631 -1 9.58121950871576 230 1619 3989 2384 781 159 215 408 1084 4242 311 443 M16856 GO_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 19/37 Gene Ontology BP GO:0010453 2.7633629810521e-08 1.97691467186943e-07 700 716.545454545455 784 2.51214819614726e-09 170 2.70008231952055 2.92110853269494 1 19.4224862761164 699 842 1149 1057 344 494 387 851 1105 784 170 444 M10270 GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLITE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 10/25 Gene Ontology BP GO:0044550 3.45618010038314e-08 1.97691467186943e-07 1840 1030.36363636364 789 3.14198195879947e-09 1 2.94012908535327 -3.159057178584 -1 21.1592680452415 1839 1006 1080 54 568 1924 3215 114 1 744 789 445 M14770 GO_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 58/98 Gene Ontology BP GO:0014902 2.76125281187501e-07 4.96449356014467e-07 2620 1325.36363636364 789 2.51023014404002e-08 98 2.78359582881793 3.72003733035103 1 18.8254033097744 2617 293 508 98 2545 2502 2297 1696 583 789 651 446 M13341 GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of chondrocyte differentiation. 52/71 Gene Ontology BP GO:0032330 2.96884145483217e-08 1.97691467186943e-07 1130 989.272727272727 791 2.69894681354172e-09 391 2.62734609063134 3.16794469893184 1 18.896226503978 1127 2283 873 755 400 791 1806 391 1124 698 634 447 M16898 GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_CYTOKINESIS.html A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. 52/66 Gene Ontology BP GO:0061640 3.54230159162849e-08 1.97691467186943e-07 2120 1213.36363636364 792 3.22027422605853e-09 88 2.08062293348881 2.35522415995308 1 14.9405855738049 2119 298 1220 88 597 2742 3816 876 100 699 792 448 M10055 GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIAL_GLIA_GUIDED_MIGRATION.html The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. 19/24 Gene Ontology BP GO:0021801 5.5142751851241e-07 8.54409671541207e-07 330 1343 795 5.01297869751949e-08 81 1.87112946469343 2.14111157177282 1 12.1411853707089 327 1973 2561 1082 2965 693 795 81 125 3604 567 449 M12364 GO_NEURAL_CREST_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_CREST_CELL_MIGRATION.html The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. 51/70 Gene Ontology BP GO:0001755 5.76391497397008e-08 2.07580109259326e-07 285 975.090909090909 796 5.23992284089313e-09 282 2.88199661537522 3.06617048736869 1 20.6727366776466 796 343 283 535 1176 1240 1091 540 2326 282 2114 450 M12797 GO_TELENCEPHALON_GLIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_GLIAL_CELL_MIGRATION.html The orderly movement of glial cells through the telencephalon. 19/24 Gene Ontology BP GO:0022030 5.5142751851241e-07 8.54409671541207e-07 330 1348.90909090909 796 5.01297869751949e-08 126 1.87112946469343 2.14111157177282 1 12.1411853707089 328 1974 2562 1083 2966 694 796 132 126 3609 568 451 M13216 GO_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. 61/90 Gene Ontology BP GO:0048546 2.37736929700324e-07 4.43795402252954e-07 875 949.818181818182 798 2.16124504900649e-08 288 2.62755171254871 3.12061306703736 1 17.9018180845622 1033 288 652 299 2444 782 871 1690 798 718 873 452 M14234 GO_NEGATIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GROWTH.html Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. 244/323 Gene Ontology BP GO:0045926 2.88614410444972e-08 1.97691467186943e-07 385 913.181818181818 798 2.62376740210233e-09 212 2.18749152569618 2.61672229112884 1 15.7137991682223 667 1416 798 1722 383 212 817 741 2048 859 382 453 M14446 GO_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_PROJECTION_REGENERATION.html The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. 36/47 Gene Ontology BP GO:0031102 3.12880223725366e-08 1.97691467186943e-07 1220 913.272727272727 799 2.84436571068268e-09 457 2.54936361031332 3.00778353517667 1 18.3320091538394 1217 528 983 1313 457 834 739 1919 799 733 524 454 M14391 GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_SOUND.html The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. 24/35 Gene Ontology BP GO:0050910 5.28761963173034e-07 8.26445890038337e-07 55 1122.36363636364 800 4.8069280932644e-08 52 4.03125930188424 4.18169504106744 1 26.3510460294649 52 1876 328 1037 3971 429 431 1999 800 918 505 455 M16580 GO_BONE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. 31/37 Gene Ontology BP GO:0070977 4.49207263351818e-08 1.97691467186943e-07 805 706.363636363636 801 4.08370247749057e-09 16 3.08388924424657 4.01396092518882 1 22.1993987973733 801 579 753 172 895 1017 1021 1038 266 1212 16 456 M11978 GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 211/267 Gene Ontology BP GO:0008654 4.24576664019313e-08 1.97691467186943e-07 245 1476.18181818182 802 3.85978792921084e-09 37 1.6300347711664 -1.65297623938584 -1 11.6804987195189 241 2612 3300 3276 802 37 203 271 1233 3964 299 457 M13284 GO_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions within an organism or cell. 53/98 Gene Ontology BP GO:0055081 3.31366109937825e-08 1.97691467186943e-07 3550 1614.09090909091 802 3.01241922662631e-09 169 2.64363338804766 -2.0181377865542 -1 19.014068046741 3547 333 802 169 527 3287 3389 2878 1786 751 286 458 M12078 GO_VENTRAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. 35/71 Gene Ontology BP GO:0021517 5.37162162912336e-08 2.05087954115883e-07 340 904.727272727273 803 4.88329250934486e-09 63 2.9589784342116 2.89100598642868 1 21.244704286479 336 1819 803 2088 1092 511 63 90 839 1687 624 459 M16818 GO_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_CIRCULATION.html Any process that modulates the frequency, rate or extent of blood circulation. 275/435 Gene Ontology BP GO:1903522 1.36615120075864e-21 1.98646923035311e-19 810 968.363636363636 806 1.24195563705331e-22 17 2.74700716544716 2.96526035424618 1 55.3316675831993 806 1371 17 26 1303 486 1615 2356 1866 48 758 460 M12944 GO_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITE_MORPHOGENESIS.html The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell. 73/93 Gene Ontology BP GO:0048813 4.48922051621019e-08 1.97691467186943e-07 770 892.181818181818 807 4.08110964346836e-09 220 2.20548991405162 2.67912000888007 1 15.8440207634224 769 220 994 637 890 769 1075 520 2143 990 807 461 M10825 GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HETEROTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion. 17/22 Gene Ontology BP GO:0034114 9.67066497001512e-07 1.36687740296113e-06 685 1133.45454545455 808 8.79151747364262e-08 187 2.89999538991437 -3.00456308990143 -1 18.2406984021214 681 1966 1090 791 3255 717 187 1008 650 1315 808 462 M12079 GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. 23/37 Gene Ontology BP GO:0030320 5.21216547642727e-08 2.03844518708446e-07 2895 1299.90909090909 809 4.73833236355649e-09 83 2.87069052445006 3.2018691392912 1 20.6156278102082 2892 704 778 83 1054 2779 2809 1510 220 809 661 463 M14264 GO_PROTEIN_DEGLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEGLYCOSYLATION.html The removal of sugar residues from a glycosylated protein. 21/22 Gene Ontology BP GO:0006517 2.73484674163466e-08 1.97691467186943e-07 745 1285.54545454545 809 2.48622434148351e-09 282 1.35124734353595 -1.23890103557565 -1 9.66342125509169 745 809 3306 1740 333 698 304 1860 282 2843 1221 464 M13241 GO_CELLULAR_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of anions at the level of a cell. 23/37 Gene Ontology BP GO:0030002 5.21216547642727e-08 2.03844518708446e-07 2895 1285 810 4.73833236355649e-09 84 2.87069052445006 3.2018691392912 1 20.6156278102082 2893 705 779 84 1055 2780 2810 1336 221 810 662 465 M11677 GO_REFLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REFLEX.html An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. 24/41 Gene Ontology BP GO:0060004 1.10594448908135e-07 2.71799508392894e-07 595 948.454545454545 812 1.00540413152492e-08 333 2.93974607089196 2.840083185594 1 20.717841640545 594 702 560 1307 1825 1156 333 1373 1331 440 812 466 M12003 GO_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MOTILITY.html Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. 851/1223 Gene Ontology BP GO:0048870 1.20470818941461e-25 3.50344200334136e-23 705 1208.45454545455 812 1.20470818941461e-26 10 2.51573704414755 2.70744865133699 1 60.8550045962991 705 1194 4338 331 519 812 1506 667 1692 10 1519 467 M15384 GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. 26/37 Gene Ontology BP GO:0099601 5.64388460779423e-07 8.727482578952e-07 1530 1226.54545454545 813 5.13080550516191e-08 170 3.26554456095311 3.67749797097484 1 21.2408969156481 1527 663 518 170 2971 1068 1015 3490 532 725 813 468 M16876 GO_CYTOSOLIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSOLIC_TRANSPORT.html The directed movement of substances or organelles within the cytosol. 231/284 Gene Ontology BP GO:0016482 2.63258516049227e-08 1.97691467186943e-07 670 1366.27272727273 813 2.3932592654496e-09 61 1.62664860618343 -1.47284149865085 -1 11.6559992033964 669 1422 3367 2476 295 61 383 1478 813 3645 420 469 M12028 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. 65/82 Gene Ontology BP GO:1904377 2.81323636085478e-08 1.97691467186943e-07 3575 1822.45454545455 817 2.55748763348079e-09 123 2.71251101603885 2.75242984703355 1 19.5124101434599 3571 258 787 123 355 3405 3787 2303 225 817 4416 470 M13350 GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 61/86 Gene Ontology BP GO:0050922 1.76731985668121e-07 3.65481746361674e-07 820 894 817 1.60665454423167e-08 145 2.82495615616872 3.17847297429257 1 19.5123190421892 817 266 336 145 2206 1334 1427 164 1863 397 879 471 M16775 GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KERATINOCYTE_PROLIFERATION.html Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. 16/17 Gene Ontology BP GO:0010839 3.41014158892439e-07 5.84649550967766e-07 400 1302 817 3.100129197744e-08 193 2.6991555890211 3.15520278676016 1 18.0440206526286 396 2478 1720 2103 2673 602 193 274 817 2412 654 472 M14254 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. 65/82 Gene Ontology BP GO:1903078 2.81323636085478e-08 1.97691467186943e-07 3575 1850.27272727273 818 2.55748763348079e-09 124 2.71251101603885 2.75242984703355 1 19.5124101434599 3572 259 788 124 356 3406 3788 2599 226 818 4417 473 M15001 GO_CONVERGENT_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONVERGENT_EXTENSION.html The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. 21/25 Gene Ontology BP GO:0060026 1.97640214990346e-07 3.94517340347524e-07 265 987.272727272727 820 1.79672938859678e-08 138 1.97261578849569 2.070894098315 1 13.5202952057243 261 820 2096 855 2292 184 138 1282 702 1996 234 474 M10898 GO_OTIC_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OTIC_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. 29/42 Gene Ontology BP GO:0071599 1.00895521760885e-07 2.59416471284394e-07 80 1093.90909090909 822 9.17232058073783e-09 78 3.85943316213972 4.30823489715669 1 27.3190630695203 78 610 277 1038 3863 790 822 1882 833 658 1182 475 M14009 GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_JOINT_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. 27/32 Gene Ontology BP GO:0072498 1.13451511604298e-07 2.75804536831137e-07 5 1118.45454545455 823 1.03137743140786e-08 2 3.8988066799368 4.09003734015054 1 27.486981542136 2 1849 280 1006 4099 553 917 1485 727 823 562 476 M15077 GO_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_RECOGNITION.html The process in which a cell in an organism interprets its surroundings. 128/345 Gene Ontology BP GO:0008037 1.13789650659902e-10 2.50930447640059e-09 825 889.636363636364 823 1.03445136968898e-11 35 2.83133028090514 3.01595028474086 1 26.1669497130637 823 1588 155 35 1891 473 748 1348 1058 251 1416 477 M16470 GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 33/42 Gene Ontology BP GO:0090314 4.04456361293506e-08 1.97691467186943e-07 1315 1164.45454545455 823 3.67687607935623e-09 235 1.83184421715022 -1.86283121476826 -1 13.1406265633832 1315 585 2547 1428 748 548 235 1803 823 2383 394 478 M11553 GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 233/320 Gene Ontology BP GO:0071229 8.12449850463955e-12 2.24251046836019e-10 815 1104.90909090909 824 7.38590773151778e-13 120 2.60819312997882 2.94852057001442 1 27.0480807475201 812 1415 120 1136 824 551 1667 2399 2271 178 781 479 M12173 GO_EMBRYO_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT.html The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. 893/1244 Gene Ontology BP GO:0009790 3.0804695300228e-08 1.97691467186943e-07 535 1123.18181818182 824 3.08046957272461e-09 144 2.19016344121953 2.39775161595402 1 15.733130960315 532 1197 4352 886 540 144 824 1481 1538 217 644 480 M12407 GO_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. 27/55 Gene Ontology BP GO:0050433 3.62819880440412e-08 1.97691467186943e-07 2635 1296.45454545455 824 3.29836260385426e-09 318 2.43405913255991 2.86037498972252 1 17.4977604016602 2632 635 824 1125 627 2600 2546 318 541 650 1763 481 M15091 GO_PROTEIN_LOCALIZATION_TO_SYNAPSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_SYNAPSE.html Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. 17/20 Gene Ontology BP GO:0035418 2.36000370228516e-07 4.41848711172251e-07 1290 939.909090909091 824 2.14545814131784e-08 179 3.21851532241487 3.38611372325581 1 21.9601910029138 1287 824 641 179 2432 1001 380 524 888 763 1420 482 M15991 GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of autophagosome assembly. 41/43 Gene Ontology BP GO:2000785 5.96481023711035e-08 2.09276523367486e-07 1135 1389.63636363636 828 5.42255490802991e-09 9 1.24658682138585 -1.08511993821306 -1 8.87290931855752 1132 509 3662 2436 1213 327 297 828 685 4188 9 483 M12157 GO_STARTLE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STARTLE_RESPONSE.html An action or movement due to the application of a sudden unexpected stimulus. 19/45 Gene Ontology BP GO:0001964 3.62070856068069e-08 1.97691467186943e-07 1040 925.545454545455 829 3.29155329115406e-09 394 2.49336370371202 2.73724978407893 1 17.9268397006271 1037 829 1016 1172 626 822 594 1610 394 1295 786 484 M15894 GO_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. 46/67 Gene Ontology BP GO:0048806 1.26612989515432e-07 2.93105480790615e-07 1035 932.090909090909 830 1.1510272436562e-08 246 2.49967360847226 3.03387729521946 1 17.5110846221009 1035 421 976 246 1945 830 711 1644 816 983 646 485 M13499 GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 29/37 Gene Ontology BP GO:0061037 6.459130814518e-08 2.15974275567375e-07 75 732.818181818182 831 5.87193727650549e-09 25 2.97909433449583 3.32911163214142 1 21.3176822491612 114 1865 831 1205 1286 71 101 75 1492 996 25 486 M12057 GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 90/106 Gene Ontology BP GO:0010812 1.01120992679847e-07 2.59632117397469e-07 370 940.818181818182 833 9.19281793888917e-09 313 2.6997803263898 2.89677987995848 1 19.0754066329156 369 1643 392 797 1745 348 852 1077 1980 833 313 487 M10248 GO_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION.html The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 411/1652 Gene Ontology BP GO:0007600 1.77174923259206e-25 4.58705804933174e-23 1495 833.545454545455 835 1.61068112053824e-26 6 2.713002611149 3.0792686849387 1 65.2929879148152 1493 1296 6 355 481 734 1790 835 1222 33 924 488 M13435 GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response. 13/29 Gene Ontology BP GO:0002739 3.2348432326148e-07 5.6163155079689e-07 295 884.454545454545 839 2.94076700750985e-08 97 2.2464445011702 -2.53841831819266 -1 15.0409422762512 293 1003 1400 839 2638 436 641 569 855 958 97 489 M16425 GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. 119/153 Gene Ontology BP GO:0001936 1.6382289582723e-07 3.46076042366852e-07 600 1097.63636363636 839 1.48929916387542e-08 435 2.69185760966409 2.93622396968207 1 18.6564971915386 597 2211 462 1216 2155 435 839 1124 1831 513 691 490 M16228 GO_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 927/1233 Gene Ontology BP GO:0060284 1.20232577893132e-14 5.88886510459728e-13 750 1132.36363636364 840 1.20232577893132e-15 49 2.29849911614875 2.58272976884443 1 30.2247160509209 750 1177 4606 351 840 457 1347 742 1288 49 849 491 M11697 GO_ORGAN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. 38/46 Gene Ontology BP GO:0048799 8.87298815697964e-08 2.46335138997725e-07 845 844.181818181818 841 8.06635319531175e-09 107 2.93952300591792 3.63408392825836 1 20.8517943343266 841 486 643 185 1603 1038 1358 1522 624 879 107 492 M13808 GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis. 77/130 Gene Ontology BP GO:0017158 6.73107772850878e-08 2.1912770361421e-07 1940 1022.27272727273 847 6.11916175859234e-09 96 2.34835644842599 -2.04450270347173 -1 16.7643736677859 1938 145 638 96 1333 847 1343 2500 585 748 1072 493 M11549 GO_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_PROLIFERATION.html The expansion of a muscle cell population by cell division. 28/33 Gene Ontology BP GO:0033002 4.05611633917912e-07 6.71800380881133e-07 850 991 850 3.68737917000102e-08 66 2.8113555490761 3.19236651591043 1 18.6156937391647 850 1856 1163 979 2771 535 460 385 462 1374 66 494 M14503 GO_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 487/735 Gene Ontology BP GO:0042493 4.86064053915306e-12 1.37905856272434e-10 855 864 852 4.41876412651255e-13 117 2.41827113939725 2.76519067595591 1 25.6213523967207 852 1281 117 918 551 350 1312 839 1841 394 1049 495 M13139 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET.html The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. 83/92 Gene Ontology BP GO:0002011 4.94972819806869e-08 2.01774734543894e-07 855 1022.90909090909 853 4.49975300857406e-09 257 3.04832083162962 3.2595824307992 1 21.9128448359957 853 1648 257 961 1171 620 1063 2803 484 717 675 496 M13771 GO_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 30/44 Gene Ontology BP GO:0033198 9.99045467779019e-08 2.57982072081111e-07 655 831 854 9.08223193769847e-09 175 2.39793962484375 2.21229712077498 1 16.937260153079 652 589 960 536 1734 854 1034 396 175 1094 1117 497 M15378 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. 37/41 Gene Ontology BP GO:0071526 9.77395063323298e-08 2.56793858252022e-07 575 1104 856 8.88541006132799e-09 128 2.64662102838331 3.41982301071242 1 18.7112159877464 573 1784 651 1691 1707 856 1212 128 2383 546 613 498 M11163 GO_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of muscle contraction. 147/232 Gene Ontology BP GO:0006937 3.43102813529934e-11 8.44686450452266e-10 875 918.727272727273 859 3.11911648668442e-12 91 2.59452893907872 2.8913424423823 1 25.2930377364656 875 1550 138 469 126 859 2417 533 2070 91 978 499 M13001 GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development. 37/48 Gene Ontology BP GO:2000171 6.16863576552034e-07 9.36738894338732e-07 1155 1333.90909090909 859 5.60785226832768e-08 204 2.12132406700947 2.10731891201962 1 13.6882770702784 1151 543 1865 603 3023 745 214 3235 204 2231 859 500 M15677 GO_GANGLION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLION_DEVELOPMENT.html The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. 19/27 Gene Ontology BP GO:0061548 4.41239799849267e-06 5.28465582676612e-06 455 1322.18181818182 860 4.01127895289034e-07 204 2.78380646108604 3.26591707008203 1 15.7409208805139 452 860 1087 1916 3930 617 332 204 3394 783 969 501 M14540 GO_RESPONSE_TO_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 544/708 Gene Ontology BP GO:0070848 3.31221582427906e-08 1.97691467186943e-07 865 1167.72727272727 861 3.31221587364754e-09 161 2.201744675482 2.45880196256424 1 15.8169232849533 665 1253 4500 580 632 161 915 749 1667 862 861 502 M12672 GO_HIPPOCAMPUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPOCAMPUS_DEVELOPMENT.html The progression of the hippocampus over time from its initial formation until its mature state. 84/129 Gene Ontology BP GO:0021766 3.34955447980659e-07 5.76812620079203e-07 165 1129.27272727273 862 3.04504999071333e-08 144 2.2552335405174 2.69898940228184 1 15.0720385700841 164 2239 1481 1409 2659 293 170 144 862 2549 452 503 M16080 GO_NEURONAL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ACTION_POTENTIAL.html An action potential that occurs in a neuron. 16/51 Gene Ontology BP GO:0019228 2.31856444150716e-08 1.97691467186943e-07 2895 1569.45454545455 862 2.1077858781294e-09 8 3.70758610623548 4.81745155587359 1 26.7119584046861 2895 862 600 157 1615 4327 4297 8 296 644 1563 504 M14176 GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html An action potential that occurs in a ventricular cardiac muscle cell. 16/30 Gene Ontology BP GO:0086005 4.71484030254755e-08 1.98252330758246e-07 4090 1748.72727272727 863 4.28621854871976e-09 35 3.81929095343975 -2.97990567897853 -1 27.5150916880447 4090 821 395 42 952 4425 3697 3581 35 335 863 505 M15075 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 110/162 Gene Ontology BP GO:0050806 4.43877382491202e-08 1.97691467186943e-07 3410 1942.36363636364 864 4.03524901315436e-09 25 2.6439947370164 2.98053563140056 1 19.0166824718886 3409 25 334 116 864 3089 3425 4465 612 411 4616 506 M12440 GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD.html The morphogenetic process in which an epithelial sheet bends along a linear axis. 20/25 Gene Ontology BP GO:0060571 2.40738155372313e-07 4.4842059125195e-07 1190 1062.90909090909 865 2.18852892468577e-08 314 3.20708371601101 3.38633146795473 1 21.8595975572386 1187 831 796 314 2453 865 439 1706 1403 1162 536 507 M15663 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport. 54/90 Gene Ontology BP GO:1901379 4.10662436568139e-08 1.97691467186943e-07 2660 1585.09090909091 865 3.73329494757962e-09 317 2.67281304548833 2.97007387857904 1 19.2251881461786 2659 317 689 573 761 3301 3586 3240 865 362 1083 508 M12916 GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. 184/216 Gene Ontology BP GO:0071559 4.1385467176385e-08 1.97691467186943e-07 560 1002.90909090909 866 3.76231526862825e-09 412 2.38981469332744 2.79118005531594 1 17.1776438811249 557 2173 543 978 769 427 866 1694 1387 1226 412 509 M10259 GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING.html The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. 589/794 Gene Ontology BP GO:0009792 3.99728054717014e-08 1.97691467186943e-07 870 1195.09090909091 868 3.99728061907227e-09 140 2.11537380188657 2.30141875547758 1 15.1920143922066 868 1237 4233 544 843 140 1045 1539 1364 594 739 510 M10438 GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 17/40 Gene Ontology BP GO:0046189 1.51649001830838e-07 3.28349374368956e-07 2615 1273.72727272727 868 1.37862738440192e-08 76 3.3567977167305 -3.39977711530515 -1 23.3756716750146 2612 868 575 76 2095 2336 2633 460 520 760 1076 511 M10709 GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 271/326 Gene Ontology BP GO:0060828 6.01126161132972e-08 2.09491454642436e-07 760 1048.09090909091 868 5.46478343234631e-09 623 2.18001695640096 2.52694026338195 1 15.6004810336337 759 1400 861 623 1221 868 1333 703 743 1977 1041 512 M12126 GO_MELANIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. 9/18 Gene Ontology BP GO:0006582 9.27838215981989e-08 2.50341608610761e-07 1305 1091.45454545455 869 9.27838254721758e-09 13 3.07612885728334 -3.159057178584 -1 21.8028160745543 1305 1039 4345 50 1752 1052 834 201 13 869 546 513 M15609 GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. 16/18 Gene Ontology BP GO:0051044 4.03385044717266e-07 6.69622052468583e-07 720 1103.45454545455 869 3.66713744255173e-08 90 2.22129926017338 -1.70946605579147 -1 14.6882165121593 716 869 1357 1505 2766 695 90 767 294 1507 1572 514 M15680 GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 103/201 Gene Ontology BP GO:0070588 2.12411767124254e-08 1.97691467186943e-07 1030 719.727272727273 869 1.93101608341006e-09 36 2.57866397800012 3.00658411370623 1 18.5440026137411 1028 36 276 887 150 869 1669 872 989 317 824 515 M11493 GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_CALCIUM_ION.html Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. 113/180 Gene Ontology BP GO:0051282 3.28772101461662e-08 1.97691467186943e-07 1830 1181.81818181818 871 2.98883733068086e-09 5 2.36826855732057 2.68700807273691 1 17.0217536899699 1829 5 368 417 513 1264 2755 3220 1449 309 871 516 M10135 GO_METANEPHRIC_NEPHRON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. 16/29 Gene Ontology BP GO:0072273 8.22909859510909e-08 2.37677062514889e-07 955 933.363636363636 873 7.48099900265319e-09 534 2.77091947690062 2.84368288164567 1 19.6957707936919 955 881 865 574 1527 820 1130 1486 622 873 534 517 M14983 GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEMAPHORIN_PLEXIN_SIGNALING_PATHWAY_INVOLVED_IN_NEURON_PROJECTION_GUIDANCE.html Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. 16/18 Gene Ontology BP GO:1902285 9.4819734660141e-07 1.34675282470585e-06 180 1304.18181818182 874 8.61997959339608e-08 69 2.97937619887843 3.35582518885576 1 18.763804799066 180 1983 967 2310 3694 262 69 104 3390 874 513 518 M15460 GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. 15/21 Gene Ontology BP GO:0035413 1.78207685786745e-08 1.97691467186943e-07 4490 1897 874 1.62006988391172e-09 76 2.67156746419822 -2.46908552499055 -1 19.2161761402508 4487 874 838 594 76 4493 3545 1634 97 739 3490 519 M14683 GO_REPLICATIVE_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLICATIVE_SENESCENCE.html A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. 19/22 Gene Ontology BP GO:0090399 9.99809556206228e-08 2.57982072081111e-07 325 932.818181818182 875 9.08917819675877e-09 5 2.73403534197084 2.96087944954083 1 19.3270418574705 321 875 1626 1261 1736 198 5 134 1835 2056 214 520 M12397 GO_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 53/76 Gene Ontology BP GO:0090183 6.91133896596084e-08 2.20844252217812e-07 1330 1044.45454545455 876 6.28303562098344e-09 335 2.86144609832315 3.03738379015709 1 20.4414474087912 1329 335 459 425 1362 894 1386 3157 547 876 719 521 M16783 GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 113/155 Gene Ontology BP GO:0010717 1.62542371439699e-07 3.44089924617343e-07 545 909.363636363636 876 1.47765803135274e-08 62 2.15973471391552 2.58879714180311 1 14.9519743510117 545 62 876 1066 2151 304 797 905 1183 1692 422 522 M13032 GO_EMBRYONIC_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PATTERN_SPECIFICATION.html The process that results in the patterns of cell differentiation that will arise in an embryo. 67/93 Gene Ontology BP GO:0009880 2.61017717791805e-08 1.97691467186943e-07 260 980.909090909091 877 2.37288837171486e-09 137 3.01778447346055 3.59245947256616 1 21.7211188240728 1828 213 259 137 289 1057 916 4076 881 257 877 523 M13647 GO_BILE_ACID_AND_BILE_SALT_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_AND_BILE_SALT_TRANSPORT.html The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/63 Gene Ontology BP GO:0015721 4.61906668850888e-08 1.97760774550163e-07 880 836.090909090909 877 4.19915162317244e-09 384 3.48521813517288 -3.69314175530052 -1 25.1025133227624 877 598 435 384 930 1259 1560 386 1154 997 617 524 M14739 GO_HINDBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDBRAIN_MORPHOGENESIS.html The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. 57/80 Gene Ontology BP GO:0021575 2.65044024197472e-08 1.97691467186943e-07 1315 1075.72727272727 877 2.40949115809616e-09 304 2.8108356513507 2.82412297183245 1 20.2238066643549 1312 1718 768 563 304 999 877 3144 539 1149 460 525 M10920 GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. 18/30 Gene Ontology BP GO:0044065 1.04959012570462e-06 1.46351299217969e-06 390 1387.45454545455 878 9.54173296772866e-08 196 1.87911749452248 2.18605384511016 1 11.7194941230173 388 878 1999 2487 3299 552 805 302 2041 2315 196 526 M11927 GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY.html Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). 254/367 Gene Ontology BP GO:0050803 1.01109918157777e-12 3.31312992386011e-11 880 702.909090909091 878 9.1918107416203e-14 85 2.59070854095602 2.93328509166564 1 29.1880453235671 878 1397 100 85 228 349 1201 1284 996 212 1002 527 M11440 GO_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. 347/433 Gene Ontology BP GO:0030111 4.65063432088194e-08 1.97800744927456e-07 590 945 879 4.22784947199351e-09 442 2.09674554439096 2.35351865609052 1 15.0566924940816 586 1342 1168 625 940 442 957 803 879 1947 706 528 M12357 GO_DETECTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS.html The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. 31/46 Gene Ontology BP GO:0016048 1.62033966292329e-08 1.97691467186943e-07 1340 783.272727272727 879 1.47303606805216e-09 50 2.98080889535169 3.52357007052906 1 21.453593828518 1339 619 879 254 50 1081 884 1106 128 1475 801 529 M15469 GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of skeletal muscle contraction. 17/25 Gene Ontology BP GO:0014819 4.16577787077152e-08 1.97691467186943e-07 705 833.909090909091 879 3.78707086332e-09 218 2.42762809194437 2.74153728505078 1 17.4512306595959 703 879 1301 1710 776 902 956 218 424 1006 298 530 M12838 GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 142/173 Gene Ontology BP GO:0010594 3.48375373746909e-08 1.97691467186943e-07 880 964.727272727273 880 3.16704890239562e-09 467 2.26309534628359 2.42795829322335 1 16.2608064849713 880 1577 648 802 581 467 1049 1227 1604 934 843 531 M12702 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 19/37 Gene Ontology BP GO:0090281 1.19265917276729e-07 2.8474408681418e-07 545 1337.90909090909 882 1.08423567038497e-08 439 1.78737115520674 1.97345382613423 1 12.5131755050449 543 882 2474 3103 1888 576 488 439 1107 2504 713 532 M14602 GO_DETECTION_OF_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_STIMULUS.html The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. 235/1291 Gene Ontology BP GO:0051606 4.41904868425099e-08 1.97691467186943e-07 1510 1085.09090909091 883 4.0173170663769e-09 308 2.31313521422299 2.6496802382525 1 16.6228539804461 1507 1430 308 1334 855 445 2036 883 2231 554 353 533 M12726 GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 36/52 Gene Ontology BP GO:0051491 8.78011616821045e-08 2.4552368046601e-07 800 943.818181818182 885 7.98192410783779e-09 245 2.26158365791657 2.73706759506838 1 16.0201791455545 798 511 1142 510 1591 1750 1222 292 245 885 1436 534 M15784 GO_REGULATION_OF_CARDIAC_CONDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_CONDUCTION.html Any process that modulates the frequency, rate or extent of cardiac conduction. 67/91 Gene Ontology BP GO:1903779 1.3710288205304e-07 3.08780111419551e-07 850 1270.09090909091 886 1.2463899145202e-08 180 2.40655329202352 2.32479021715225 1 16.7957678588775 848 249 868 180 2009 886 1547 3650 2075 521 1138 535 M12239 GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease. 18/18 Gene Ontology BP GO:0042982 2.24601759589907e-06 2.85071645367999e-06 225 1613.36363636364 887 2.04183626263644e-07 143 1.77677519146093 -1.77801459099568 -1 10.5198147681367 221 887 2277 2840 3634 220 143 661 4251 1884 729 536 M10722 GO_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that modulates the frequency, rate or extent of developmental growth. 335/478 Gene Ontology BP GO:0048638 2.32075191647115e-10 4.9308030444476e-09 1025 965.363636363636 889 2.10977446974179e-11 161 2.40672433864892 2.58697442654821 1 21.4638232515954 1025 1338 161 448 614 882 1624 1970 889 279 1389 537 M12561 GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 21/50 Gene Ontology BP GO:0071378 1.92876500573326e-07 3.88508379726271e-07 560 1291.27272727273 889 1.75342288620936e-08 303 1.63603310769884 -1.87148153932912 -1 11.2058315746628 559 844 2785 853 2272 912 1267 303 335 3185 889 538 M15054 GO_PARAXIAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARAXIAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. 17/23 Gene Ontology BP GO:0048339 1.19771321060131e-07 2.84948968717509e-07 1725 1066.63636363636 889 1.0888302507333e-08 254 2.10797110281158 -1.52218511777444 -1 14.7772337077838 1724 889 2171 849 1897 1092 372 400 765 1320 254 539 M11912 GO_FOREBRAIN_GENERATION_OF_NEURONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_GENERATION_OF_NEURONS.html The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. 70/114 Gene Ontology BP GO:0021872 7.26103446923276e-07 1.07494729192937e-06 775 1350.45454545455 892 6.60094260519698e-08 319 2.8741218077253 3.29903845741558 1 18.4006006479444 772 2663 434 1560 3110 892 546 514 2158 319 1887 540 M14062 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 46/74 Gene Ontology BP GO:0010524 3.47865357574466e-08 1.97691467186943e-07 2660 1801.63636363636 893 3.16241239159031e-09 261 2.47063150211562 2.29325120847991 1 17.7623681104028 2660 388 893 511 579 3092 3626 4252 261 706 2850 541 M15173 GO_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix. 139/169 Gene Ontology BP GO:0001952 8.15194766740851e-08 2.37217088783313e-07 535 1118.45454545455 893 7.41086179043025e-09 154 2.28405596674435 2.63357948352554 1 16.2173337919164 535 2199 754 1077 1517 154 723 893 2671 1601 179 542 M13563 GO_SEGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENTATION.html The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. 100/137 Gene Ontology BP GO:0035282 2.75109096378434e-08 1.97691467186943e-07 900 820.727272727273 897 2.50099181653329e-09 93 2.25067637339524 2.64874324882723 1 16.1709529698493 897 93 1028 1381 339 252 268 1401 1929 951 489 543 M13755 GO_ENDODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. 82/113 Gene Ontology BP GO:0007492 3.73136467059993e-09 6.45428989304887e-08 230 864.181818181818 897 3.39214970629873e-10 112 2.76266074201213 3.27961862739677 1 21.3247017938198 229 112 199 911 1936 829 897 1905 1067 470 951 544 M15696 GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPARAN_SULFATE_PROTEOGLYCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. 25/30 Gene Ontology BP GO:0015012 9.1040075820923e-08 2.48889231959315e-07 900 973.181818181818 897 8.27637087166639e-09 71 2.61207245120743 2.57981434297162 1 18.5037646200917 731 1881 1210 900 1635 764 486 213 71 1917 897 545 M12865 GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 228/317 Gene Ontology BP GO:0090092 5.40671650570536e-08 2.05366954294261e-07 905 982.545454545455 901 4.91519694416431e-09 169 2.41053665616102 2.55523538876266 1 17.2845349108382 901 2151 373 709 1102 169 1261 1360 1689 831 262 546 M14509 GO_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. 47/82 Gene Ontology BP GO:0046530 1.88303369388235e-07 3.81942274526354e-07 1180 889.272727272727 901 1.71184895914165e-08 172 2.80329200125805 3.0671499474131 1 19.3039326469702 1177 383 579 480 2253 1074 1385 172 315 1063 901 547 M10758 GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 102/128 Gene Ontology BP GO:0006661 2.17458109848109e-07 4.19325563664837e-07 485 1748.63636363636 902 1.97689210311519e-08 117 1.4298142579287 -1.40050632533024 -1 9.72794690385407 483 2648 3644 3411 2372 117 305 902 648 4374 331 548 M15540 GO_CELL_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a junction between cells. 94/122 Gene Ontology BP GO:0007043 1.19846364018948e-07 2.84948968717509e-07 4115 1752.27272727273 902 1.08951245952413e-08 23 2.42549245180176 -2.38139869975099 -1 17.0201478081388 4115 80 521 23 1898 4387 4195 841 679 902 1634 549 M11417 GO_REGULATION_OF_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELINATION.html Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. 46/53 Gene Ontology BP GO:0031641 4.5264037725779e-08 1.97760774550163e-07 905 1168.63636363636 903 4.11491260518788e-09 387 2.97569947126155 4.07748534707173 1 21.4161373398819 2891 417 952 614 903 1996 901 817 387 1379 1598 550 M15398 GO_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_GROWTH.html The increase in size or mass of the heart. 32/43 Gene Ontology BP GO:0060419 4.32843899030822e-07 7.02729470408379e-07 830 1178.18181818182 903 3.93494531083348e-08 120 2.7503516119235 3.15116217568439 1 18.1512720443847 830 588 835 1322 2827 906 1440 561 2628 903 120 551 M16968 GO_HEAD_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEAD_MORPHOGENESIS.html The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. 55/69 Gene Ontology BP GO:0060323 8.49144713980326e-08 2.42396954242359e-07 50 868 903 7.71949769777433e-09 50 2.88752410015162 3.29599930754616 1 20.502746035948 50 1721 538 1028 1556 202 362 1758 903 1179 251 552 M10682 GO_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CYCLE.html The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. 98/143 Gene Ontology BP GO:0042633 2.12309181956731e-07 4.13163790733864e-07 695 1326.90909090909 904 1.93008365859505e-08 379 2.70373232804567 2.99342136278374 1 18.5147578094129 691 1635 379 1729 2347 852 904 716 3479 687 1177 553 M15229 GO_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. 991/1348 Gene Ontology BP GO:0030030 1.16620114960851e-09 2.17925058197927e-08 635 1156.90909090909 904 1.16620115022052e-10 116 2.13819468945103 2.37270048492015 1 17.5670784715335 634 1171 4542 367 521 904 1297 476 1305 116 1393 554 M11423 GO_REGULATION_OF_DOPAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of dopamine. 15/27 Gene Ontology BP GO:0014059 6.78116532374645e-08 2.19879876316322e-07 1555 897.545454545455 906 6.16469593887779e-09 52 2.46905502489391 2.77147350065311 1 17.6278602117415 1552 906 1111 746 1340 1460 860 52 112 979 755 555 M14927 GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. 104/168 Gene Ontology BP GO:0055067 1.21244498538636e-07 2.87033193211408e-07 1355 1233.36363636364 907 1.10222277473235e-08 68 2.27087380409249 -2.04128987083313 -1 15.9201924373488 1351 68 757 2235 1905 907 1817 552 2666 417 892 556 M13989 GO_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSPORT.html The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 176/297 Gene Ontology BP GO:0006816 1.29513504989365e-08 1.92832376826627e-07 495 897.545454545455 909 1.17739550683462e-09 218 2.4864046674861 2.73509712492255 1 17.9054919890547 909 1498 218 890 492 493 1185 1219 1668 233 1068 557 M13134 GO_CELL_SEPARATION_AFTER_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SEPARATION_AFTER_CYTOKINESIS.html The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components. 17/17 Gene Ontology BP GO:0000920 4.1381371244271e-08 1.97691467186943e-07 715 1434.36363636364 911 3.76194291114934e-09 67 1.13665726533411 -0.923478940994253 -1 8.11082322544027 712 911 3378 3864 767 388 67 1044 1660 2596 391 558 M13236 GO_RELAXATION_OF_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_MUSCLE.html A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. 28/37 Gene Ontology BP GO:0090075 6.4611259744205e-08 2.15974275567375e-07 545 1037.90909090909 912 5.87375105834157e-09 42 2.81061795680568 2.99092972064254 1 20.1057098278836 544 1861 890 1918 1288 301 282 1421 1958 912 42 559 M13904 GO_METANEPHRIC_NEPHRON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_NEPHRON_DEVELOPMENT.html The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. 26/42 Gene Ontology BP GO:0072210 3.65515378371623e-08 1.97691467186943e-07 375 994.909090909091 912 3.3228671313129e-09 375 2.75791038263188 2.80096997303406 1 19.8408827723457 375 1870 912 1132 637 480 599 1712 1426 1125 676 560 M15345 GO_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. 38/91 Gene Ontology BP GO:0048663 5.00240153673208e-07 7.90063075603515e-07 915 1173.63636363636 912 4.54763879471631e-08 102 3.1678488983978 3.13809993783938 1 20.7498341315705 734 2723 874 1073 2912 477 102 422 912 1767 914 561 M10808 GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT.html The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. 120/184 Gene Ontology BP GO:0048706 4.63694401534984e-08 1.97760774550163e-07 915 969.272727272727 913 4.21540373916617e-09 250 2.7506035917448 3.27090526266285 1 19.787564918754 449 1602 250 953 2265 913 1094 1163 913 490 570 562 M11483 GO_CHONDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHONDROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. 39/43 Gene Ontology BP GO:0002063 8.66341725827568e-09 1.40947134625024e-07 265 876.818181818182 914 7.87583390217408e-10 212 3.18587891335636 3.59872753317564 1 23.4425077925589 262 423 212 914 2267 1025 1322 1537 372 312 999 563 M12681 GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/33 Gene Ontology BP GO:0051953 5.21901670050395e-08 2.03844518708446e-07 905 902.363636363636 916 4.74456074937606e-09 57 3.60158520143634 3.61449026699768 1 25.8932831316587 903 988 650 570 1059 916 1085 1740 57 805 1153 564 M13149 GO_HEPATOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a hepatocyte, the main structural component of the liver. 16/17 Gene Ontology BP GO:0097284 9.31507054307015e-08 2.50682609814375e-07 1120 1045.54545454545 916 8.46824630680157e-09 55 2.51160813470672 -3.45320633182926 -1 17.7792795735261 1118 916 1989 771 1663 1390 726 64 55 2398 411 565 M12415 GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. 43/50 Gene Ontology BP GO:0048745 2.20285355082653e-06 2.80051299781307e-06 30 1215.72727272727 918 2.00259614230948e-07 29 3.55755894843357 3.83028061807456 1 21.2063427185701 29 1770 365 1423 3828 632 867 1199 1556 786 918 566 M13884 GO_MOLTING_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOLTING_CYCLE.html The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. 98/143 Gene Ontology BP GO:0042303 2.12309181956731e-07 4.13163790733864e-07 695 1346.18181818182 918 1.93008365859505e-08 380 2.70373232804567 2.99342136278374 1 18.5147578094129 692 1636 380 1730 2348 853 905 918 3480 688 1178 567 M15095 GO_RESPIRATORY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_DEVELOPMENT.html The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. 227/307 Gene Ontology BP GO:0060541 4.56926602426409e-08 1.97760774550163e-07 1410 1188.36363636364 918 4.15387829014996e-09 344 2.49654588006055 2.63185824713359 1 17.9494531616126 1407 1438 344 731 918 515 1642 3199 1836 467 575 568 M12411 GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DERMATAN_SULFATE_PROTEOGLYCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. 15/17 Gene Ontology BP GO:0050655 1.44907756024012e-07 3.19401131586796e-07 255 1136.09090909091 922 1.3173433233516e-08 252 2.80552409663818 2.95625193916899 1 19.5545368712172 252 2015 1396 1837 2055 475 263 743 805 1734 922 569 M12140 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. 133/160 Gene Ontology BP GO:2001237 3.9226697167018e-08 1.97691467186943e-07 630 1039.54545454545 925 3.56606344240385e-09 9 2.43982619685014 2.62688543670428 1 17.5394861549146 626 9 708 646 715 925 1325 2390 1349 1255 1487 570 M14261 GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 24/37 Gene Ontology BP GO:0009190 6.226856630746e-08 2.12948256567067e-07 125 1141.54545454545 926 5.66077891544573e-09 27 2.48479284657735 2.50826289392264 1 17.7782472687888 125 1903 972 2706 1249 85 27 926 3445 917 202 571 M13742 GO_MITOTIC_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. 90/105 Gene Ontology BP GO:0007052 2.60549336917971e-07 4.74438140955168e-07 395 1251.18181818182 927 2.36863061613845e-08 393 1.9763061092307 2.05185711597063 1 13.3749267971671 393 2230 1816 1845 2513 680 682 541 927 1479 657 572 M11583 GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 32/49 Gene Ontology BP GO:0051023 9.22979287020366e-07 1.3165611963537e-06 60 1540.81818181818 928 8.39072431130608e-08 59 1.50411188594917 -1.50728985591078 -1 9.4327248457399 59 597 2732 1980 3231 334 606 648 3930 1904 928 573 M13589 GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_TRANSMEMBRANE_TRANSPORT.html The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 18/29 Gene Ontology BP GO:0034219 1.97753840483403e-07 3.9457487983245e-07 3495 1796.45454545455 928 1.79776234781022e-08 153 2.97954347123174 -2.90882499963507 -1 20.4792980863753 3491 863 928 693 2293 2699 2554 831 153 890 4366 574 M12312 GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of adenylate cyclase activity. 44/86 Gene Ontology BP GO:0045761 2.41361071063848e-08 1.97691467186943e-07 960 1031.09090909091 929 2.19419157919827e-09 238 2.64664578760933 2.7094573718642 1 19.0358633024358 959 467 907 1506 238 463 929 2162 2438 1008 265 575 M14727 GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. 104/151 Gene Ontology BP GO:1904064 4.62762316365326e-08 1.97760774550163e-07 2550 1508.90909090909 929 4.206930237267e-09 59 2.46262853099518 2.64458110026385 1 17.7040605786643 2546 59 448 458 937 2341 3558 4207 929 374 741 576 M16017 GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 29/55 Gene Ontology BP GO:0032892 3.86093596810059e-08 1.97691467186943e-07 1505 1060.54545454545 929 3.50994185078081e-09 508 2.70109381806453 3.33282614837306 1 19.4298046510364 1502 633 827 929 693 1542 1569 508 1837 999 627 577 M14957 GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_A_POLARIZED_EPITHELIUM.html The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. 43/51 Gene Ontology BP GO:0001738 2.99704417278353e-08 1.97691467186943e-07 1595 1140.09090909091 930 2.72458564873821e-09 389 2.48734947391545 3.14171243352536 1 17.8833256602284 1592 424 930 752 406 1625 1317 3387 931 788 389 578 M15304 GO_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 204/277 Gene Ontology BP GO:0048863 2.61794199193729e-14 1.18153132136118e-12 805 1072.27272727273 930 2.37994726539756e-15 68 2.70656962033069 3.06311112640621 1 34.7274703256624 805 2159 68 930 1515 654 715 1136 2366 202 1245 579 M15995 GO_MESENCHYME_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYME_MORPHOGENESIS.html The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. 47/58 Gene Ontology BP GO:0072132 7.75042799988714e-07 1.13191278981403e-06 3600 1770.81818181818 930 7.04584611845789e-08 238 3.21649396708369 4.28040566080457 1 20.5281483979753 3597 1755 529 738 3152 3585 3233 930 797 925 238 580 M13073 GO_ENDODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. 55/73 Gene Ontology BP GO:0035987 4.63994818985332e-09 7.85079233723182e-08 60 1095.63636363636 931 4.21813472694481e-10 60 3.15257970235464 3.46738197446252 1 24.0609876064536 60 1709 204 931 3128 770 938 1614 1148 635 915 581 M12807 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport. 65/94 Gene Ontology BP GO:1904427 1.19951356316682e-07 2.85052942258182e-07 1960 1242.27272727273 932 1.09046693506211e-08 221 2.47793497245409 2.57582066400398 1 17.3901687011472 1956 261 846 531 1899 1459 2182 2751 627 932 221 582 M10078 GO_MITOTIC_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CYTOKINESIS.html A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. 44/56 Gene Ontology BP GO:0000281 3.73931994919262e-08 1.97691467186943e-07 2140 1316.27272727273 933 3.39938182977226e-09 56 2.1572562357378 2.44137995721362 1 15.4950413765822 2138 350 1052 73 659 3200 4287 933 56 601 1130 583 M12908 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. 44/56 Gene Ontology BP GO:1901021 6.93856482773969e-08 2.20979754575447e-07 1010 891.454545454545 934 6.30778640597691e-09 117 2.47190646527616 2.67614969363289 1 17.6425676898566 1009 447 1104 564 1366 934 886 1215 762 1402 117 584 M13215 GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). 418/1835 Gene Ontology BP GO:0007186 1.77449054132756e-25 4.58705804933174e-23 935 937 934 1.61317321938869e-26 7 2.5116846741415 2.68967861765672 1 60.4395395009156 934 1292 7 12 325 328 1811 1931 2588 19 1060 585 M16163 GO_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 407/596 Gene Ontology BP GO:0048568 1.34663675166894e-09 2.47664063459113e-08 1130 913.909090909091 934 1.22421522953929e-10 135 2.33002353045146 2.51301365306188 1 19.0135586958391 1129 1309 188 934 685 135 1441 1868 1623 229 512 586 M11465 GO_NEURAL_RETINA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_RETINA_DEVELOPMENT.html The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. 52/87 Gene Ontology BP GO:0003407 4.28456989474352e-08 1.97691467186943e-07 2730 1511.72727272727 935 3.89506361653353e-09 332 2.55747079662784 2.94091386158472 1 18.3906661132078 2727 332 639 477 811 2872 4190 1321 935 593 1732 587 M16001 GO_POSITIVE_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 117/178 Gene Ontology BP GO:0050921 3.72422647435475e-08 1.97691467186943e-07 540 1088.27272727273 935 3.38566048854507e-09 359 2.66195441297846 2.83994190208942 1 19.1466239759205 538 2210 359 1500 654 544 935 1081 2720 375 1055 588 M11118 GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_GASEOUS_EXCHANGE_BY_NEUROLOGICAL_SYSTEM_PROCESS.html A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. 15/27 Gene Ontology BP GO:0002087 2.14843793252655e-07 4.16181586180101e-07 210 1119.36363636364 937 1.95312558394092e-08 38 2.20134775412619 2.34586286481564 1 15.0459790819728 208 937 1685 2073 3203 247 322 38 1774 1731 95 589 M14237 GO_REGULATION_OF_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. 459/729 Gene Ontology BP GO:0044057 1.01780831207397e-24 2.25517241718105e-22 940 1034.90909090909 938 9.25280283703612e-26 10 2.65537501547107 2.88749212657061 1 61.9215871704429 938 1284 10 878 853 378 1555 2349 2012 37 1090 590 M16423 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 16/33 Gene Ontology BP GO:0090208 2.44368674345866e-08 1.97691467186943e-07 535 1337.90909090909 939 2.22153342782029e-09 246 1.63505298883481 -1.61501004286159 -1 11.7168064320172 533 939 2931 3303 246 393 955 925 1654 2410 428 591 M11397 GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 46/67 Gene Ontology BP GO:0009187 1.33922800972106e-07 3.03972094108883e-07 95 1315 940 1.21748008295021e-08 88 2.43708323860025 2.50267900731395 1 17.0282028634762 92 2299 944 3274 1993 132 88 940 3380 705 618 592 M13978 GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 78/103 Gene Ontology BP GO:0061178 5.28596730092277e-08 2.04581932255101e-07 865 886.636363636364 940 4.80542493448125e-09 199 2.38001372776366 2.67605266303203 1 17.0685132322762 861 199 1229 256 1074 940 506 1450 761 1314 1163 593 M12350 GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. 41/72 Gene Ontology BP GO:0001754 1.22448529726873e-07 2.88336542924665e-07 1775 1026.90909090909 941 1.11316851401968e-08 140 2.99283676909055 3.44193228190047 1 21.0111886349127 1772 459 497 468 1916 1667 1879 140 304 941 1253 594 M12776 GO_EMBRYONIC_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_ORGAN_MORPHOGENESIS.html Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 283/440 Gene Ontology BP GO:0048562 3.31980740475521e-10 6.77502800628334e-09 600 736.090909090909 941 3.01800673205106e-11 40 2.36996167070993 2.6895116606113 1 20.7812852408032 598 1370 168 947 1148 128 941 1258 1307 192 40 595 M14697 GO_CELLULAR_COMPONENT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MORPHOGENESIS.html The process in which cellular structures, including whole cells or cell parts, are generated and organized. 977/1351 Gene Ontology BP GO:0032989 1.91233060750323e-14 8.89807431671255e-13 625 1104.63636363636 942 1.91233060750324e-15 52 2.27668214562237 2.5283189917366 1 29.4962898749191 625 1172 4512 334 585 540 1077 1274 1038 52 942 596 M13126 GO_NEURON_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. 11/44 Gene Ontology BP GO:0048665 7.45271522015042e-07 1.09808372132235e-06 1005 1023.45454545455 943 6.77519794984709e-08 113 4.30921125596852 4.53262862793577 1 27.6017402481976 1005 1025 943 629 3126 712 163 590 113 1786 1166 597 M11925 GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 16/23 Gene Ontology BP GO:0071732 4.41057674665592e-07 7.14320000076227e-07 945 1584.81818181818 945 4.00961602808359e-08 112 1.68010673515131 1.78316385472622 1 11.0311718639717 942 945 2377 3360 2836 801 114 257 4187 1502 112 598 M10430 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. 24/45 Gene Ontology BP GO:0045956 5.60029486499997e-08 2.05622555659363e-07 1560 1025.54545454545 948 5.09117727960042e-09 551 2.34008062104231 -1.90636446344013 -1 16.7746663837602 1558 728 1421 723 1142 948 742 551 787 1419 1262 599 M10345 GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. 51/73 Gene Ontology BP GO:0046470 2.35572248814188e-07 4.41848711172251e-07 155 1065.72727272727 950 2.14156612762605e-08 64 2.32391517908883 -2.14586421063763 -1 15.824825704749 154 1735 1271 2474 2430 64 103 295 950 1879 368 600 M13634 GO_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTIVESICULAR_BODY_SORTING_PATHWAY.html A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. 12/12 Gene Ontology BP GO:0071985 2.94938062558269e-07 5.23321537821719e-07 505 1170.36363636364 950 2.68125547362261e-08 92 1.53920421963067 -1.36723453893712 -1 10.3210178829739 505 971 2522 1874 2582 254 220 950 92 2558 346 601 M14400 GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMOOLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein homooligomerization. 18/19 Gene Ontology BP GO:0032462 3.64403174116621e-08 1.97691467186943e-07 1105 1035.45454545455 951 3.31275618320467e-09 108 2.66259343405328 -3.0713718972372 -1 19.1512474089794 1101 894 1414 951 633 1762 1902 183 108 1893 549 602 M14450 GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_BIOGENIC_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. 13/23 Gene Ontology BP GO:0042402 5.47977416225048e-08 2.05617623085131e-07 955 1236.36363636364 952 4.9816129988555e-09 247 2.25469757800805 -2.49916977012545 -1 16.1585041244092 952 1013 1901 3598 1113 784 247 438 576 2274 704 603 M15199 GO_AMINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 13/23 Gene Ontology BP GO:0009310 5.47977416225048e-08 2.05617623085131e-07 955 1234 953 4.9816129988555e-09 248 2.25469757800805 -2.49916977012545 -1 16.1585041244092 953 1014 1902 3599 1114 785 248 402 577 2275 705 604 M10283 GO_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. 323/410 Gene Ontology BP GO:0006644 2.82972795074103e-08 1.97691467186943e-07 740 1425.72727272727 956 2.57247998830738e-09 118 1.80469730449592 -1.7142359608287 -1 12.9442137401466 737 1354 2281 4076 367 118 913 956 1622 2730 529 605 M15697 GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle contraction. 84/122 Gene Ontology BP GO:0055117 4.58869639587766e-08 1.97760774550163e-07 1015 1085.72727272727 956 4.17154226507944e-09 407 2.53994743935812 2.76322355986651 1 18.26346416287 1013 1657 578 956 919 567 1676 1410 1855 407 905 606 M16055 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 50/54 Gene Ontology BP GO:0060999 4.62244689358228e-08 1.97760774550163e-07 295 966 956 4.20222453700462e-09 79 2.02641233035514 2.44428171687945 1 14.5480291331455 291 1744 1707 1047 933 583 303 79 973 2010 956 607 M13948 GO_OOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. 40/71 Gene Ontology BP GO:0009994 8.76478555400861e-08 2.45512816355666e-07 335 1039.72727272727 957 7.96798718472463e-09 331 2.80977438470428 2.70006583694893 1 19.9308213681658 1301 483 758 553 1589 957 334 2147 331 1229 1755 608 M14848 GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_C_SIGNALING.html Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 14/17 Gene Ontology BP GO:0090036 1.17615414179589e-06 1.61292225811266e-06 845 1400.18181818182 957 1.0692316096242e-07 379 2.70253508296275 -2.23571601583522 -1 16.7813299469499 2856 957 1101 730 3357 2064 841 379 495 845 1777 609 M13935 GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 71/88 Gene Ontology BP GO:0043535 4.24479816806766e-08 1.97691467186943e-07 995 1227.45454545455 958 3.85890749997188e-09 242 2.04788972752145 2.2794835193888 1 14.7037549080305 993 242 1603 664 801 958 889 2718 755 1906 1973 610 M13011 GO_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a cell population. 767/1073 Gene Ontology BP GO:0008283 5.52645421322825e-08 2.05617623085131e-07 615 1271 960 5.52645435066587e-09 248 2.30606092897403 2.48600053193501 1 16.5291808850034 612 1215 4400 916 1230 373 960 487 2160 248 1380 611 M11487 GO_MITOTIC_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. 97/102 Gene Ontology BP GO:0000070 2.05401599166685e-07 4.04800356172209e-07 115 1288.27272727273 961 1.86728743948979e-08 101 1.57603793315119 1.78226252978614 1 10.7604086327358 115 101 3064 2729 2320 517 233 961 2146 1044 941 612 M12339 GO_REGULATION_OF_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_AGGREGATION.html Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. 21/26 Gene Ontology BP GO:0090330 1.88272466722189e-07 3.81942274526354e-07 870 1038 961 1.71156802576587e-08 348 3.46090659129853 3.84646753251786 1 23.8589067394058 866 827 623 1363 2252 961 348 1109 1041 616 1412 613 M13798 GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRESYNAPTIC_PROCESS_INVOLVED_IN_SYNAPTIC_TRANSMISSION.html The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. 111/170 Gene Ontology BP GO:0099531 4.74192022829918e-08 1.98252330758246e-07 1920 1132.90909090909 962 4.31083666409762e-09 19 2.40562621833348 -2.35390903352873 -1 17.2888487851856 1918 19 405 422 962 1288 2405 2412 770 344 1517 614 M10663 GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. 23/30 Gene Ontology BP GO:0006656 1.97882099645578e-06 2.53998733696793e-06 970 1550.27272727273 966 1.79892979666949e-07 263 2.06788978913867 -1.71922147323896 -1 12.3738174348765 966 2794 2091 2481 3591 964 587 263 426 2357 533 615 M10308 GO_BODY_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_MORPHOGENESIS.html The process in which the anatomical structures of the soma are generated and organized. 62/79 Gene Ontology BP GO:0010171 5.36465887258514e-08 2.05087954115883e-07 80 943.909090909091 967 4.87696273036485e-09 80 2.69573937387362 3.17549259606917 1 19.3446540340228 80 1700 583 1033 1091 374 769 1944 967 1364 478 616 M13227 GO_LOCALIZATION_OF_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_OF_CELL.html Any process in which a cell is transported to, and/or maintained in, a specific location. 851/1223 Gene Ontology BP GO:0051674 1.20470818941461e-25 3.50344200334136e-23 710 1243.63636363636 968 1.20470818941461e-26 11 2.51573704414755 2.70744865133699 1 60.8550045962991 706 1195 4415 332 520 813 1507 968 1693 11 1520 617 M13919 GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 268/336 Gene Ontology BP GO:0006650 4.17342931622888e-08 1.97691467186943e-07 570 1177.81818181818 973 3.79402672309035e-09 56 1.83187639369346 -1.73725722363096 -1 13.1408593664934 567 1395 1921 2477 777 56 781 973 1466 2219 324 618 M16440 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. 82/112 Gene Ontology BP GO:1901019 4.03295375883465e-08 1.97691467186943e-07 165 1063.09090909091 974 3.66632166615016e-09 165 2.27654135408395 2.4789213656118 1 16.3580907834461 1644 165 931 165 744 1096 1576 2334 1585 974 480 619 M15720 GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 11/17 Gene Ontology BP GO:0002283 2.17413104503191e-07 4.19325563664837e-07 770 1555.27272727273 975 1.97648296353506e-08 272 1.70582181725605 -1.62369853968169 -1 11.6276360992681 770 2552 2691 1952 2371 881 272 445 975 3347 852 620 M12165 GO_HYPOTHALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPOTHALAMUS_DEVELOPMENT.html The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. 18/35 Gene Ontology BP GO:0021854 1.39340991037222e-07 3.11452674737746e-07 980 1311.09090909091 977 1.26673636238761e-08 335 2.62240769022655 3.28318337318457 1 18.3018060601486 977 870 1152 1565 2026 835 335 731 3452 889 1590 621 M15765 GO_VESICLE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_DOCKING.html The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. 54/63 Gene Ontology BP GO:0048278 6.24361035025475e-08 2.12948256567067e-07 700 1845.63636363636 979 5.67600957040791e-09 386 1.39102753933079 -1.1848001557949 -1 9.90276886278612 698 386 3477 4359 1251 814 419 979 3150 3866 903 622 M14575 GO_PEROXISOMAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOMAL_TRANSPORT.html Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 21/21 Gene Ontology BP GO:0043574 9.11035041517602e-06 1.05109001938542e-05 980 1898.18181818182 980 8.28217103816243e-07 278 1.41352869269756 -0.779752436244328 -1 7.48151341420762 980 2808 3258 2893 4306 503 491 278 665 4126 572 623 M14293 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. 30/60 Gene Ontology BP GO:0032753 1.3376256520896e-06 1.80352713971976e-06 355 1411.36363636364 981 1.21602405943844e-07 351 1.79154556731828 -1.64884545173742 -1 10.9926453111319 351 592 1808 1569 3418 598 981 900 2682 1646 980 624 M15320 GO_RESPONSE_TO_MINERALOCORTICOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MINERALOCORTICOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. 38/50 Gene Ontology BP GO:0051385 4.82931981203165e-08 1.990761933901e-07 625 1498.18181818182 981 4.39029083458388e-09 277 2.79190126323254 2.86344499257303 1 20.0776789969584 623 3685 1560 1988 981 748 277 888 2163 2948 619 625 M11220 GO_THYMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMUS_DEVELOPMENT.html The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. 57/80 Gene Ontology BP GO:0048538 6.81557704518639e-08 2.20228333272585e-07 665 1282.90909090909 984 6.19597932393841e-09 316 1.81442938264347 2.16376340152026 1 12.9228168564913 663 1733 2574 316 1346 984 858 1424 525 2734 955 626 M14054 GO_VITAMIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_TRANSPORT.html The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 31/42 Gene Ontology BP GO:0051180 6.88684336892962e-08 2.20745225825723e-07 2840 1169.90909090909 984 6.26076689501293e-09 45 3.02156658670641 -3.21499809168436 -1 21.5922715738953 2838 593 726 45 1357 2153 1462 624 86 984 2001 627 M14792 GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neuron migration. 23/24 Gene Ontology BP GO:2001224 2.20280608717664e-07 4.22317953178117e-07 140 1028.18181818182 984 2.00255118885295e-08 12 3.03532737753935 3.34321782985274 1 20.7681652569191 137 1920 984 1369 2882 200 12 40 1747 1614 405 628 M16471 GO_BILE_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 31/68 Gene Ontology BP GO:0008206 2.66518132825459e-08 1.97691467186943e-07 2050 1170.63636363636 986 2.4228921459471e-09 95 2.962302991217 -2.56989663675105 -1 21.3197002648584 2049 555 586 95 308 2165 2780 1388 1048 986 917 629 M13576 GO_SKIN_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. 89/111 Gene Ontology BP GO:0098773 1.73068156025742e-07 3.60278591263368e-07 610 1370.81818181818 987 1.57334699673232e-08 512 2.69043088592624 3.02904234994412 1 18.5958321232221 606 1647 512 1763 2190 987 830 869 3599 881 1195 630 M13721 GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. 184/242 Gene Ontology BP GO:0045017 6.423942175831e-08 2.15816627755535e-07 255 1420.09090909091 987 5.83994760309857e-09 43 1.68623494407816 -1.68351494533644 -1 12.0177868144937 254 2615 2876 3040 1280 43 328 471 987 3467 260 631 M14991 GO_REGULATION_OF_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. 177/261 Gene Ontology BP GO:0050920 2.5830766978321e-10 5.41398913288863e-09 515 1111.27272727273 987 2.34825154375944e-11 164 2.65204275999984 2.86182376315181 1 23.546964619956 512 2616 164 1112 1470 645 1067 897 2586 168 987 632 M10293 GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of adipocyte differentiation. 114/139 Gene Ontology BP GO:0045598 2.33783300425986e-08 1.97691467186943e-07 1660 996.727272727273 988 2.12530275372989e-09 71 2.5837967589151 2.86130236379509 1 18.5811392120499 1657 71 566 611 201 1000 988 1669 1026 946 2229 633 M10686 GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_KINETOCHORE.html Any process in which a protein is transported to, or maintained at, the kinetochore. 12/13 Gene Ontology BP GO:0034501 4.72137083664481e-06 5.61711544436418e-06 145 1467 988 4.292164517367e-07 15 1.71353798761347 1.71353798761347 1 9.59664901003256 144 2898 2567 1953 3882 217 15 519 939 2015 988 634 M12766 GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION.html The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 162/271 Gene Ontology BP GO:0009952 5.06637170133657e-08 2.02998167617902e-07 840 1146 988 4.60579256182714e-09 149 2.09828670440832 2.36061701576897 1 15.0423344795355 836 1536 988 1012 1021 149 888 2695 2015 950 516 635 M16714 GO_EXTRACELLULAR_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins. 31/36 Gene Ontology BP GO:0043206 4.24378653281988e-07 6.93308123521039e-07 25 1348.45454545455 988 3.85798850131265e-08 21 3.57386307988264 3.96333026631105 1 23.6426069324783 21 2339 322 1346 4277 857 966 1626 1291 988 800 636 M10720 GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 62/91 Gene Ontology BP GO:0048168 3.15494253879375e-08 1.97691467186943e-07 1195 928.909090909091 989 2.86812962185243e-09 249 2.50255995536358 2.72524727444968 1 17.993376244693 1193 287 741 249 460 989 1095 1791 1047 893 1473 637 M15722 GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. 200/298 Gene Ontology BP GO:0090257 2.58232927700486e-08 1.97691467186943e-07 1055 1024.90909090909 989 2.34757209755989e-09 204 2.40124614534663 2.57567683138518 1 17.2603525041413 1052 1478 289 568 282 708 2166 989 2287 204 1251 638 M14192 GO_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REMODELING.html The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. 116/161 Gene Ontology BP GO:0048771 4.8233679691813e-08 1.990761933901e-07 2510 1224 991 4.38488006811885e-09 44 2.84236045183402 3.1985881902077 1 20.4425952717013 2506 44 253 192 991 2309 2637 775 1717 548 1492 639 M10725 GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. 29/44 Gene Ontology BP GO:0007202 5.0215119674449e-08 2.02375063519002e-07 1850 1284 993 4.56501098369199e-09 393 3.16281965921637 -3.22768944738026 -1 22.7357633628415 1846 637 677 774 1015 2009 2896 393 2036 993 848 640 M11502 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MEMBRANE.html Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. 38/54 Gene Ontology BP GO:0090313 2.15898764788407e-08 1.97691467186943e-07 995 1132.72727272727 994 1.96271606279224e-09 161 1.69817304014865 -1.66458612616298 -1 12.173491420077 994 536 2865 1793 161 360 167 1412 1103 2671 398 641 M15451 GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT.html Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 558/721 Gene Ontology BP GO:0010720 4.49511223476866e-08 1.97691467186943e-07 175 1089.81818181818 997 4.4951123256958e-09 173 2.35172119763671 2.68569287280637 1 16.9020305496626 593 1239 4557 397 997 174 1090 1057 1101 173 610 642 M15296 GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_GLUTAMATERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. 29/51 Gene Ontology BP GO:0035249 5.58123915659833e-08 2.05617623085131e-07 715 1071 998 5.07385390744573e-09 320 2.60259852592781 3.27274465663678 1 18.6692203054461 715 600 761 1333 1139 825 1101 1645 2344 998 320 643 M11005 GO_APICAL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_JUNCTION_ASSEMBLY.html The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. 55/65 Gene Ontology BP GO:0043297 1.8317724670002e-07 3.75142486309504e-07 60 1311.27272727273 999 1.66524783592542e-08 57 2.43650503752051 -2.38253471554139 -1 16.7838934406279 2151 304 999 57 2229 2332 3994 97 58 1581 622 644 M13680 GO_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTION.html Self-propelled movement of a cell or organism from one location to another. 1068/1674 Gene Ontology BP GO:0040011 1.99510306190617e-32 2.32080363676235e-29 875 1234.45454545455 999 1.99510306190617e-33 2 2.49299410563324 2.66171426221021 1 76.9281595677613 872 1163 4443 325 391 618 1528 999 1581 2 1657 645 M14858 GO_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a second cell of the identical type via adhesion molecules. 75/108 Gene Ontology BP GO:0034109 2.07418909032758e-08 1.97691467186943e-07 1165 977.090909090909 999 1.88562646353029e-09 137 2.47582323398688 2.7083306261273 1 17.799931229543 1165 178 605 524 137 1631 1655 1394 999 866 1594 646 M14976 GO_FEMALE_MEIOTIC_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_MEIOTIC_DIVISION.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. 24/32 Gene Ontology BP GO:0007143 8.79725395599873e-07 1.26455429895774e-06 210 1256 1000 7.99750679436747e-08 207 2.00221784337217 2.03731280064691 1 12.6317692034267 207 759 2463 1924 3206 406 274 403 1000 2113 1061 647 M10152 GO_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of neurological system. 684/2079 Gene Ontology BP GO:0050877 3.29489474417359e-17 2.39549144447495e-15 1195 1184.45454545455 1001 3.29489474417361e-18 30 2.51035362639969 2.8090134946921 1 39.4978163191801 1192 1217 4229 352 923 407 1653 711 1314 30 1001 648 M13940 GO_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH.html The increase in size or mass of an entire organism, a part of an organism or a cell. 445/577 Gene Ontology BP GO:0040007 3.53205046945237e-08 1.97691467186943e-07 1005 1004.90909090909 1001 3.21095502378059e-09 235 2.29330628064256 2.55996399178444 1 16.4793880594444 1001 1293 245 482 596 924 1626 2042 1532 235 1078 649 M16168 GO_PROTEIN_LIPID_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_REMODELING.html The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. 14/28 Gene Ontology BP GO:0034368 5.13986072047086e-08 2.03397493965704e-07 3075 1603.54545454545 1002 4.67260076413948e-09 182 4.10635271383263 4.43378426231486 1 29.5423413739978 3074 960 553 521 1038 3742 4186 1002 182 848 1533 650 M16683 GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 18/30 Gene Ontology BP GO:0061213 2.20020392989004e-07 4.22317953178117e-07 1820 1111.36363636364 1002 2.00018559084623e-08 421 2.60922266263151 2.93439259447734 1 17.8368160202167 1818 853 1002 562 2383 1520 547 1139 421 1169 811 651 M13908 GO_NEUROGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROGENESIS.html Generation of cells within the nervous system. 1416/1999 Gene Ontology BP GO:0022008 8.7131469106425e-21 1.03954545064666e-18 550 1054.63636363636 1003 8.71314691064249e-22 2 2.28279920795098 2.57891151937576 1 44.1914433790406 548 1147 4459 2 649 361 1074 1050 1290 18 1003 652 M12444 GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. 658/835 Gene Ontology BP GO:0031344 6.26712686366429e-09 1.03775591802954e-07 1005 1148.18181818182 1004 6.26712688133888e-10 10 2.30849063384168 2.61127102754096 1 17.2865731029126 1004 1218 4369 10 487 545 1561 1296 779 139 1222 653 M12174 GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of striated muscle contraction. 91/141 Gene Ontology BP GO:0006942 3.69820268051287e-08 1.97691467186943e-07 1955 1108.45454545455 1006 3.36200249334518e-09 104 2.46560069727164 2.78788566496229 1 17.7259693274125 1415 104 515 557 650 1006 2498 1954 1951 291 1252 654 M15447 GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 99/136 Gene Ontology BP GO:0072329 1.91868442666936e-08 1.97691467186943e-07 370 1317.45454545455 1007 1.7442585849116e-09 86 1.67724380570426 -1.50655201934873 -1 12.0220646233082 368 86 2575 2713 105 507 1007 845 1629 3218 1439 655 M16913 GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 225/273 Gene Ontology BP GO:0010770 5.21137732065647e-08 2.03844518708446e-07 670 966.727272727273 1007 4.73761585827637e-09 460 2.3575912220544 2.83783176566819 1 16.9106326187166 664 1442 460 1007 1053 666 1401 934 1324 1013 670 656 M12387 GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_TRANSPORT.html The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. 58/62 Gene Ontology BP GO:0006893 3.16235769346922e-08 1.97691467186943e-07 760 1555.63636363636 1010 2.87487067175097e-09 421 1.36828696875705 -1.49438314870475 -1 9.78670602559908 756 2687 3781 1991 465 614 1196 429 1010 3762 421 657 M12643 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_CENTROMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. 14/15 Gene Ontology BP GO:0071459 2.88895132112565e-06 3.56843389891098e-06 180 1322 1010 2.62632283162459e-07 40 1.77089714704878 1.79463422590428 1 10.2982503241679 177 2482 2356 1556 3738 243 40 681 729 1530 1010 658 M13653 GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. 25/31 Gene Ontology BP GO:0045879 1.92833506301548e-07 3.88508379726271e-07 1010 1165.54545454545 1010 1.75303202912467e-08 564 2.24752308189568 2.40553907277344 1 15.4364377440722 707 662 1607 767 2271 1010 564 1009 1294 1589 1341 659 M14867 GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). 14/28 Gene Ontology BP GO:0034369 5.13986072047086e-08 2.03397493965704e-07 3075 1603.27272727273 1010 4.67260076413948e-09 181 4.10635271383263 4.43378426231486 1 29.5423413739978 3073 959 552 520 1037 3741 4185 1010 181 846 1532 660 M10877 GO_MODIFIED_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFIED_AMINO_ACID_TRANSPORT.html The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 27/36 Gene Ontology BP GO:0072337 5.22091171916738e-07 8.18769876281963e-07 3885 1849.63636363636 1011 4.74628450742193e-08 49 3.40134431410096 -4.14012542326491 -1 22.2306982148057 3881 650 703 51 2934 3842 4244 760 49 1011 2221 661 M16560 GO_PLATELET_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_AGGREGATION.html The adhesion of one platelet to one or more other platelets via adhesion molecules. 56/83 Gene Ontology BP GO:0070527 2.35211736793966e-08 1.97691467186943e-07 730 1000.27272727273 1011 2.13828853917017e-09 205 2.43575344496586 2.60644104411971 1 17.5100190583751 730 320 892 1697 205 1356 1429 1230 473 1660 1011 662 M14962 GO_ENDODERM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERM_FORMATION.html The formation of the endoderm during gastrulation. 63/84 Gene Ontology BP GO:0001706 1.12156507633513e-08 1.77740684677253e-07 90 1103.81818181818 1012 1.01960462004809e-09 87 2.91383880399298 3.27835033757294 1 21.1143419307231 87 1688 214 946 2490 824 1024 1832 1495 530 1012 663 M16319 GO_KINETOCHORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KINETOCHORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. 12/12 Gene Ontology BP GO:0051383 9.58620761805043e-06 1.1029827904745e-05 320 1674.45454545455 1012 8.71477217175538e-07 113 2.23664544645796 2.23664544645796 1 11.8534383039758 320 2923 2684 2763 4017 1012 113 642 924 2027 994 664 M10421 GO_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a gland are generated and organized. 142/166 Gene Ontology BP GO:0022612 1.41710463863788e-11 3.72530388902941e-10 1230 1197 1014 1.28827694422455e-12 118 2.86553206542406 3.00547282094309 1 29.0462675053607 1228 1554 127 118 1279 656 1014 4426 900 263 1602 665 M12755 GO_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE.html An immune response mediated through a body fluid. 112/484 Gene Ontology BP GO:0006959 8.07727712052965e-10 1.55948425069811e-08 815 1230.45454545455 1014 7.34297920317747e-11 34 2.57411719194639 -2.61815109582827 -1 21.5753343927214 813 34 177 1463 1014 1423 2449 2259 2882 326 695 666 M16534 GO_BIOLOGICAL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOLOGICAL_ADHESION.html The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. 953/1424 Gene Ontology BP GO:0022610 1.47353714199587e-37 6.8563683217068e-34 580 1184.90909090909 1015 1.47353714199587e-38 1 2.66148614857993 2.87516555580372 1 95.1455668595845 576 1170 4632 871 433 244 1415 1113 1564 1 1015 667 M13622 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 13/15 Gene Ontology BP GO:0010867 3.13007943656778e-08 1.97691467186943e-07 580 1500.54545454545 1016 2.84552680100127e-09 458 1.59350057777766 -1.55585895836719 -1 11.4161672222494 910 1016 2935 2775 458 580 1234 2526 579 2796 697 668 M13890 GO_OOCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. 25/45 Gene Ontology BP GO:0001556 7.71972107518601e-08 2.30947065667097e-07 1285 1064.36363636364 1016 7.01792849642571e-09 440 2.82031842616105 2.64868234956219 1 20.0868867006214 1282 703 844 1168 1464 761 474 1576 440 1016 1980 669 M11382 GO_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRIL_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, insoluble fibrous aggregates consisting of polysaccharides and/or proteins. 41/47 Gene Ontology BP GO:0097435 5.34600683052603e-06 6.33434422776614e-06 20 1209.09090909091 1019 4.86001801943947e-07 16 3.06186915169123 3.2555140080579 1 17.0645002364953 16 1774 436 1019 3901 391 461 1498 1854 1351 599 670 M13542 GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. 63/94 Gene Ontology BP GO:0050891 2.66951873520056e-09 4.68727195278801e-08 4305 1999.09090909091 1019 2.42683521676346e-10 60 3.00195769160387 -3.01110898352702 -1 23.6317082921463 4303 224 196 60 1019 4375 4464 3443 2651 459 796 671 M14813 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. 1093/1430 Gene Ontology BP GO:0022603 1.44070069848158e-13 5.63326079834858e-12 895 1217.90909090909 1019 1.44070069848168e-14 19 2.2784952288832 2.57621967623419 1 27.5490513142334 891 1166 4517 19 377 1019 1696 580 1626 57 1449 672 M14931 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_APICAL_BASAL_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. 46/60 Gene Ontology BP GO:0035088 1.50849548962292e-07 3.27227483133587e-07 1650 1421.90909090909 1019 1.37135963005219e-08 414 2.7809534354239 3.32919728457852 1 19.350735007761 1649 414 1019 732 2092 1844 948 4524 471 707 1241 673 M15632 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_BIPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. 46/60 Gene Ontology BP GO:0061245 1.50849548962292e-07 3.27227483133587e-07 1650 1423.18181818182 1020 1.37135963005219e-08 415 2.7809534354239 3.32919728457852 1 19.350735007761 1650 415 1020 733 2093 1845 949 4528 472 708 1242 674 M16110 GO_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_PROLIFERATION.html The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. 37/52 Gene Ontology BP GO:0007405 1.12845754055343e-06 1.5599266001768e-06 795 1232.63636363636 1020 1.02587101761772e-07 90 2.41695382588871 2.91456919885466 1 15.0339151781594 1020 1814 1730 794 3333 793 1114 230 407 2234 90 675 M11432 GO_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 47/50 Gene Ontology BP GO:0044088 8.72048732897202e-08 2.45512816355666e-07 965 1559.45454545455 1021 7.92771606785435e-09 216 1.17628550403548 -0.984791296638217 -1 8.27809968670418 962 441 3777 2446 1577 225 378 1873 1021 4238 216 676 M16570 GO_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_GROWTH.html The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. 172/205 Gene Ontology BP GO:0016049 1.12266665826817e-07 2.74357560972784e-07 545 1096.81818181818 1023 1.0206061050529e-08 403 2.28220784799257 2.6853213385238 1 16.0485281945563 839 1518 541 545 1837 972 1467 1178 1742 403 1023 677 M13092 GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THE_FORCE_OF_HEART_CONTRACTION.html Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. 37/62 Gene Ontology BP GO:0002026 1.00293136952024e-07 2.5839643756244e-07 1310 1185.45454545455 1025 9.11755832037874e-09 537 2.42598036386508 2.53480126550284 1 17.1348167152391 1309 537 946 1571 1740 1031 896 1025 2637 671 677 678 M16545 GO_RESPONSE_TO_HISTAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HISTAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. 2/19 Gene Ontology BP GO:0034776 1.76688748237834e-07 3.65481746361674e-07 920 1393.4 1025 1.9632084679212e-08 2 3.97816299157687 -3.97816299157687 -1 27.5238291196374 916 1134 4633 NA 2361 534 2 1335 339 2180 500 679 M14556 GO_DIENCEPHALON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIENCEPHALON_DEVELOPMENT.html The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. 63/125 Gene Ontology BP GO:0021536 7.34871755340554e-08 2.26356255727441e-07 1030 1075.09090909091 1027 6.68065254443336e-09 225 2.77423663553752 3.06727187351453 1 19.7829427034082 1027 256 376 225 1416 1203 835 2766 1925 299 1498 680 M12061 GO_GLYCEROLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. 316/425 Gene Ontology BP GO:0046486 3.30901918649833e-08 1.97691467186943e-07 695 1230.63636363636 1029 3.00819930569935e-09 79 1.85654890663499 -1.77252077672096 -1 13.3193694602524 693 1357 1792 3024 524 79 1029 673 1904 1988 474 681 M10052 GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 12/19 Gene Ontology BP GO:0071402 1.25151497609166e-07 2.91456415603329e-07 785 1165.90909090909 1031 1.13774095207878e-08 228 2.387969736109 2.55411078218023 1 16.7298209302907 782 1031 1553 1578 1935 650 228 231 2758 1549 530 682 M10246 GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PURINE_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process. 108/204 Gene Ontology BP GO:1900544 2.48335207586156e-08 1.97691467186943e-07 1035 1407.90909090909 1031 2.25759282172141e-09 253 2.13240026534255 2.32684487641364 1 15.3152039349628 1031 1626 1182 1984 253 396 894 2830 3771 646 874 683 M12576 GO_MACROMOLECULAR_COMPLEX_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_REMODELING.html The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. 14/28 Gene Ontology BP GO:0034367 5.13986072047086e-08 2.03397493965704e-07 3075 1604.18181818182 1031 4.67260076413948e-09 180 4.10635271383263 4.43378426231486 1 29.5423413739978 3072 958 551 519 1036 3740 4184 1031 180 844 1531 684 M15769 GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to a muscle, across a synapse. 21/40 Gene Ontology BP GO:0007274 4.03327305448552e-08 1.97691467186943e-07 4045 1877.36363636364 1031 3.66661193493432e-09 605 2.37587273771494 -1.82491114327413 -1 17.0767713105251 4043 763 964 2066 745 2826 3036 605 1030 1031 3542 685 M13998 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 108/204 Gene Ontology BP GO:0045981 2.48335207586156e-08 1.97691467186943e-07 1035 1424.81818181818 1032 2.25759282172141e-09 254 2.13240026534255 2.32684487641364 1 15.3152039349628 1032 1627 1183 1985 254 397 895 3006 3772 647 875 686 M15227 GO_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MORPHOGENESIS.html The process in which bones are generated and organized. 97/125 Gene Ontology BP GO:0060349 1.03264579189703e-07 2.62706444488622e-07 325 1040.45454545455 1032 9.38768945788931e-09 316 2.83260229267593 3.12890345404695 1 20.0038011807647 323 1633 316 1032 1763 806 1050 1562 1657 582 721 687 M16015 GO_AMINOGLYCAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINOGLYCAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. 58/79 Gene Ontology BP GO:0006026 9.8877718388668e-08 2.57170499531846e-07 650 1183.36363636364 1033 8.98888389387907e-09 314 2.35010563712074 2.95367449622483 1 16.6006110392721 647 314 1033 2060 1724 1518 2083 726 1193 926 793 688 M11568 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of epithelial cell proliferation. 186/243 Gene Ontology BP GO:0050679 6.86065915135223e-11 1.62043893559604e-09 1035 825.090909090909 1034 6.23696286506015e-12 146 2.71090685201165 2.93389020059143 1 25.6048449797041 1034 1506 146 213 490 1075 1421 459 1458 224 1050 689 M13772 GO_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within an organism or cell. 70/109 Gene Ontology BP GO:0030104 7.02017288345386e-11 1.64145047370406e-09 4630 1937.63636363636 1035 6.38197534879806e-12 27 3.00094137337689 2.96706780264149 1 28.3382354568251 4630 170 148 27 863 4586 4381 2945 2209 320 1035 690 M16954 GO_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of vasculature development. 269/372 Gene Ontology BP GO:1901342 4.53701967948688e-16 2.97334543220457e-14 370 944.727272727273 1035 4.12456334498807e-17 43 2.68580667675105 2.86136682495658 1 39.0956495394411 370 1392 43 927 1101 586 1035 1046 2424 131 1337 691 M15023 GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of glia cell differentiation. 66/97 Gene Ontology BP GO:0045685 2.50359900710216e-07 4.6171597062325e-07 2055 1289.90909090909 1037 2.27599935637423e-08 358 2.81661602757768 3.56040516652324 1 19.1458131290209 2055 1705 821 653 2477 845 1037 2003 358 1483 752 692 M15832 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of endothelial cell proliferation. 81/103 Gene Ontology BP GO:0001938 3.41878739952443e-07 5.85700212444299e-07 950 1351.18181818182 1039 3.10798902800195e-08 525 2.37033511163713 2.48766533489166 1 15.8300629053446 948 2248 987 1255 2675 525 1057 1039 2765 727 637 693 M13646 GO_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 461/645 Gene Ontology BP GO:0009314 4.59136499094399e-08 1.97760774550163e-07 820 1190.72727272727 1040 4.1739682606955e-09 155 1.99459428259179 2.14338332547624 1 14.3178250299307 820 1295 1281 2523 921 155 967 1040 2191 1412 493 694 M13048 GO_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEARNING.html Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. 147/227 Gene Ontology BP GO:0007612 5.837700854118e-08 2.0762333639785e-07 1480 1162 1041 5.3070009172922e-09 714 2.35665575952586 2.53961135011332 1 16.8835889729967 1478 1569 714 1356 1191 903 1865 921 848 1041 896 695 M13473 GO_FACE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FACE_DEVELOPMENT.html The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. 76/90 Gene Ontology BP GO:0060324 1.21569456404157e-07 2.8743022390678e-07 295 1099.18181818182 1043 1.10517693747223e-08 295 2.6158453388626 3.09629586928077 1 18.3541366538875 295 1680 706 1074 1909 379 740 2485 1435 1043 345 696 M14034 GO_SYNAPTIC_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_SIGNALING.html Cell-cell signaling to or from a synapse. 337/577 Gene Ontology BP GO:0099536 2.40868358376217e-21 3.2021727757844e-19 1950 1226.63636363636 1043 2.1897123488747e-22 5 2.5153813166612 2.8556858131912 1 50.0936775156109 1946 1326 18 5 156 1043 2871 4080 921 31 1096 697 M15044 GO_RESPONSE_TO_THYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_THYROID_HORMONE.html A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 29/42 Gene Ontology BP GO:0097066 1.81888266851455e-08 1.97691467186943e-07 790 1210.36363636364 1043 1.65352971232038e-09 85 2.54138304557336 -2.70344775781096 -1 18.2742683244656 789 1859 1862 2507 85 1078 766 523 654 2148 1043 698 M10927 GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS.html The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. 96/145 Gene Ontology BP GO:0048704 6.40210119793897e-07 9.64981434208294e-07 530 1219.09090909091 1044 5.82009369180058e-08 355 2.87837599412222 3.46975339694614 1 18.5735970597997 526 1640 355 1015 3049 1144 1223 1579 1044 882 953 699 M13392 GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway. 12/14 Gene Ontology BP GO:2000052 1.04408136544365e-06 1.45801638457662e-06 1125 1237.27272727273 1044 9.49165328133327e-08 221 2.38426304316279 2.74382971940661 1 14.9045439259507 1124 1020 1674 1044 3295 908 221 1403 309 2019 593 700 M15773 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. 16/22 Gene Ontology BP GO:0055026 5.97027225715428e-08 2.09276523367486e-07 1165 1024.81818181818 1046 5.4275203810665e-09 571 2.65897068487281 3.443055373131 1 19.0540624210397 1161 893 1046 818 1214 842 1166 761 1293 1508 571 701 M11139 GO_SECOND_MESSENGER_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECOND_MESSENGER_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. 176/251 Gene Ontology BP GO:0019932 1.5182690062488e-09 2.7595725336233e-08 585 1084.09090909091 1047 1.38024455208781e-10 191 2.52025750083301 2.87102236975588 1 20.4473683541777 583 1505 191 1101 1808 365 962 1927 2227 209 1047 702 M10587 GO_PROSTATE_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_MORPHOGENESIS.html The process in which the anatomical structures of a prostate gland are generated and organized. 31/37 Gene Ontology BP GO:0060512 1.01163341680982e-07 2.59632117397469e-07 1685 1536.27272727273 1048 9.19666784843732e-09 250 3.15236713083612 3.45576279100881 1 22.2921364404774 1682 596 698 250 1746 1048 914 3725 643 1474 4123 703 M15028 GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of B cell differentiation. 21/26 Gene Ontology BP GO:0045579 5.19074682343256e-08 2.03844518708446e-07 540 1052.72727272727 1049 4.71886085991328e-09 308 2.11001539662023 -1.96123566325916 -1 15.1229333595665 536 811 2049 1215 1049 816 1425 308 1736 1286 349 704 M12263 GO_PROXIMAL_DISTAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROXIMAL_DISTAL_PATTERN_FORMATION.html The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). 26/48 Gene Ontology BP GO:0009954 4.91642559526015e-07 7.79425154846525e-07 450 1245.18181818182 1053 4.46947881268478e-08 315 2.87531392766679 3.28289916729521 1 18.8415161284991 448 1884 1053 2118 2901 411 318 987 2138 1124 315 705 M13009 GO_TERPENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERPENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. 87/174 Gene Ontology BP GO:0006721 2.18518796995709e-08 1.97691467186943e-07 1000 1098.81818181818 1053 1.98653453787441e-09 165 2.69436903054857 2.65256985252033 1 19.3811495970162 998 1659 471 1484 165 1053 1059 964 2509 542 1183 706 M14814 GO_FEMALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GAMETE_GENERATION.html Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. 99/155 Gene Ontology BP GO:0007292 2.2012744327471e-07 4.22317953178117e-07 735 1143.45454545455 1055 2.00115877545645e-08 108 2.44505273245468 2.46733806714018 1 16.7074236838343 732 108 1004 1712 2384 689 459 1055 1133 1426 1876 707 M10890 GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. 60/70 Gene Ontology BP GO:0045600 2.81982155437878e-08 1.97691467186943e-07 1060 1247.90909090909 1058 2.56347417320134e-09 358 2.77702721617433 2.83035451114624 1 19.9791965207719 1058 2680 875 1725 358 1083 1020 945 777 1203 2003 708 M11314 GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDUCTION_OF_POSITIVE_CHEMOTAXIS.html Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 10/12 Gene Ontology BP GO:0050930 2.74520710655819e-08 1.97691467186943e-07 1405 1267.27272727273 1059 2.49564285528497e-09 130 3.44799220160579 3.26412750278962 1 24.8337495507872 1402 1059 962 130 337 1205 900 4348 133 1564 1900 709 M11744 GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_SPINAL_CORD.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. 36/82 Gene Ontology BP GO:0021515 6.56480487197668e-08 2.17413460714792e-07 1395 1137 1060 5.96800460715509e-09 412 2.60879660497055 2.46491132286773 1 18.6457418698702 990 558 1044 1395 1300 1060 412 702 1392 2099 1555 710 M12903 GO_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 403/509 Gene Ontology BP GO:0070482 3.87234894375764e-08 1.97691467186943e-07 1065 1252.27272727273 1061 3.52031728356102e-09 201 2.38969669201844 2.61957950683761 1 17.1767901203109 1061 2984 378 1055 699 201 1725 1965 1926 1099 682 711 M14745 GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 10/16 Gene Ontology BP GO:0034375 7.12148979687316e-08 2.23814099129341e-07 1960 1210.63636363636 1061 6.47408184308975e-09 62 4.01850548310839 4.23600262806756 1 28.727759647697 1958 1061 781 546 1388 2658 3153 187 62 1072 451 712 M15988 GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 77/141 Gene Ontology BP GO:0030801 2.39318314990224e-08 1.97691467186943e-07 1020 1538.09090909091 1061 2.17562106903231e-09 226 2.24533637669061 2.38489919411987 1 16.1323171278223 1016 2250 1061 2318 226 526 1289 2911 3900 577 845 713 M16729 GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_ORGAN_DEVELOPMENT.html Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. 20/23 Gene Ontology BP GO:0048569 5.22206460993914e-08 2.03844518708446e-07 680 1649.63636363636 1061 4.74733157626683e-09 515 2.29752882286185 2.58792999890164 1 16.4769331395732 680 3485 1793 3402 1061 621 680 917 2323 2669 515 714 M14448 GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. 29/36 Gene Ontology BP GO:0060351 1.15554249625134e-06 1.59075125297559e-06 85 1300.54545454545 1062 1.05049373017868e-07 84 3.42906850381002 3.93285451052188 1 21.3453730132371 84 1835 345 1029 4046 1062 1490 1895 1164 660 696 715 M16504 GO_AUTOPHAGOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. 47/52 Gene Ontology BP GO:1905037 1.17021246405144e-07 2.82053557561036e-07 300 1641.45454545455 1064 1.0638295693607e-08 242 1.52255500316369 -1.65877549299595 -1 10.6492473130927 297 1772 3531 3907 1869 242 252 1064 883 3956 283 716 M10519 GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIC_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides. 24/54 Gene Ontology BP GO:0030800 3.0037103389447e-07 5.30811401713243e-07 1070 1161.27272727273 1066 2.73064613549839e-08 567 3.43960028230967 3.27621718065396 1 23.1807079137755 1068 752 595 1116 2592 935 1066 1823 1330 567 930 717 M15370 GO_NEURAL_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_FORMATION.html The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. 124/142 Gene Ontology BP GO:0001841 2.51778558262226e-08 1.97691467186943e-07 905 1122.90909090909 1067 2.28889601039728e-09 1 1.83563726685632 2.01709767205942 1 13.1680699640725 905 1 1903 1750 269 601 1549 1855 1424 1067 1028 718 M14755 GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic hydroxy compound. 157/247 Gene Ontology BP GO:1901617 2.61380888426741e-08 1.97691467186943e-07 945 1159.90909090909 1068 2.37618992301995e-09 291 2.38682812915462 -2.2232193024798 -1 17.1560355491415 941 1541 568 1824 291 1061 1477 1068 1208 1045 1735 719 M10483 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. 35/50 Gene Ontology BP GO:0048662 2.46488015106806e-08 1.97691467186943e-07 2190 1310.18181818182 1069 2.24080016244052e-09 251 3.02686082566205 2.98616034531844 1 21.7867878739308 2190 1829 913 1875 251 2186 1887 1069 722 968 522 720 M10835 GO_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_LOCALIZATION.html Any process in which is the spindle is transported to, and/or maintained in, a specific location. 49/67 Gene Ontology BP GO:0051653 5.263246536928e-08 2.04581932255101e-07 830 1255.27272727273 1069 4.78476969349555e-09 381 2.03430030138308 2.23919947507004 1 14.572765619374 828 396 1908 2491 1069 862 1363 381 1398 2185 927 721 M10442 GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TEMPERATURE_STIMULUS.html The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 32/50 Gene Ontology BP GO:0050951 4.56111558095599e-08 1.97760774550163e-07 1955 1067.90909090909 1070 4.14646879592601e-09 132 2.76716896229801 3.31123740971176 1 19.9074156494144 1951 586 909 245 914 1593 1687 1070 132 1346 1314 722 M16970 GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of stem cell differentiation. 162/226 Gene Ontology BP GO:2000736 1.3132086741979e-07 3.00411010867397e-07 945 1089.27272727273 1070 1.19382613871368e-08 186 2.14160449978006 2.49233041787452 1 14.9617728531412 943 1547 833 1070 1975 672 1251 186 1347 1480 678 723 M10505 GO_COLLAGEN_FIBRIL_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLAGEN_FIBRIL_ORGANIZATION.html Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. 54/60 Gene Ontology BP GO:0030199 3.83275040863555e-09 6.58073345069418e-08 10 1345.63636363636 1071 3.48431855937528e-10 9 3.55552826669374 3.8018681148575 1 27.4448933205922 9 2281 201 1685 4048 1071 1027 1384 1582 501 1013 724 M12631 GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of adherens junction organization. 94/107 Gene Ontology BP GO:1903391 4.95899389536473e-08 2.01774734543894e-07 835 1278 1071 4.50817637013166e-09 685 2.21715594896178 2.59529453862064 1 15.9071810822831 833 1642 1024 1071 1002 685 1134 1654 2331 1748 934 725 M13818 GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_INTRACELLULAR_DOMAIN_PROTEOLYSIS.html The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. 20/21 Gene Ontology BP GO:0031293 1.10069142599892e-07 2.70836446598252e-07 215 1568.81818181818 1073 1.0006286191528e-08 53 1.36524310735177 -1.09937803552899 -1 9.56323927039262 215 2430 3244 3368 1822 187 53 832 1073 3681 352 726 M14288 GO_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_POLYMERIZATION.html Assembly of actin filaments by the addition of actin monomers to a filament. 28/38 Gene Ontology BP GO:0030041 6.34619473928269e-08 2.14132299651069e-07 1080 1007 1076 5.76926811122473e-09 123 2.37029749993123 -2.61351024086131 -1 16.94768209032 1076 1853 1580 1154 1272 671 237 123 270 2376 465 727 M16014 GO_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIOGENESIS.html Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. 98/139 Gene Ontology BP GO:0014013 1.17746932421568e-07 2.82410554926575e-07 2175 1128.09090909091 1076 1.07042671566855e-08 92 2.65948299089571 3.35192054629536 1 18.6841692489559 2174 92 569 635 1880 1109 1076 1709 531 772 1862 728 M12783 GO_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIOGENESIS.html The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. 187/263 Gene Ontology BP GO:0042063 1.9065466127312e-08 1.97691467186943e-07 1080 885.909090909091 1078 1.73322420841233e-09 129 2.5735676800008 2.9547492844977 1 18.507129975926 1080 1486 232 129 1078 730 1182 1263 700 764 1101 729 M16855 GO_STEROID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 20/65 Gene Ontology BP GO:0006706 4.76202877698804e-08 1.98252330758246e-07 1080 1450 1079 4.32911716369542e-09 250 3.28226460335712 -3.49887662494552 -1 23.6303220076523 1079 2813 867 2254 969 990 2204 250 2232 1472 820 730 M12122 GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS.html The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. 15/29 Gene Ontology BP GO:0048557 2.45001432824695e-06 3.08022606574793e-06 995 1492.27272727273 1081 2.22728823335656e-07 792 3.02146841846627 3.69438659825638 1 17.8588840149712 991 2885 1466 1081 3671 1158 818 812 792 1732 1009 731 M15024 GO_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOMINERAL_TISSUE_DEVELOPMENT.html Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. 84/111 Gene Ontology BP GO:0031214 4.94041201872582e-12 1.39319618928068e-10 660 1180.72727272727 1082 4.49128365339719e-13 118 3.14782210747678 3.42799399031123 1 33.3699467931098 659 1660 118 1706 2124 937 1082 1448 2076 406 772 732 M15143 GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 70/102 Gene Ontology BP GO:0060193 9.24892430335912e-08 2.50183514628907e-07 1235 1223.90909090909 1082 8.40811335653557e-09 215 2.91283519285123 -2.95071989296079 -1 20.6402910234508 1232 1686 547 804 1652 1082 2421 215 2091 838 895 733 M11842 GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. 26/54 Gene Ontology BP GO:0021522 9.66124021833328e-08 2.54407191487859e-07 435 1219 1083 8.78294603873093e-09 110 2.3516840651618 2.18465986062588 1 16.6237444095308 432 1891 1484 3045 1703 561 110 212 1083 2459 429 734 M12951 GO_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. 37/52 Gene Ontology BP GO:0045445 3.95167267954315e-07 6.5856493473905e-07 1475 1225.54545454545 1083 3.59243035395332e-08 180 2.50615794314508 2.87855431302956 1 16.6058904070348 1473 1791 1083 822 2756 953 227 180 1655 1656 885 735 M11235 GO_CELLULAR_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENTATION.html The deposition or aggregation of coloring matter in a cell. 48/56 Gene Ontology BP GO:0033059 1.62932113612808e-07 3.44695594860932e-07 930 1450.36363636364 1085 1.48120114254154e-08 430 1.63704232386907 -1.54062202169431 -1 11.304622291883 930 430 3036 1887 2152 652 746 1547 858 2631 1085 736 M13650 GO_MESODERM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_MORPHOGENESIS.html The process in which the anatomical structures of the mesoderm are generated and organized. 77/111 Gene Ontology BP GO:0048332 3.92916437984876e-08 1.97691467186943e-07 385 1161.09090909091 1086 3.5719676818391e-09 159 2.27885039503419 2.59762400893492 1 16.3747971123675 383 2253 1335 2010 717 386 592 1086 1877 1974 159 737 M16924 GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_STRUCTURE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. 288/418 Gene Ontology BP GO:0043062 7.00709596575627e-34 1.0868005842888e-30 1090 1013.63636363636 1088 6.37008724159665e-35 2 3.09584121977626 3.39823351926707 1 100 76 2136 2 1090 2132 1029 1088 1072 1151 41 1333 738 M10413 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_INTERNEURON_MIGRATION.html The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. 8/21 Gene Ontology BP GO:0021843 5.91270615643762e-07 9.05291929776382e-07 985 1451.54545454545 1089 5.91270772964244e-08 39 3.65563553398908 4.4795987018089 1 23.7290447532733 984 2065 4238 1146 3053 1089 521 88 39 1032 1712 739 M14347 GO_REGULATION_OF_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. 77/107 Gene Ontology BP GO:0006885 3.69136796426334e-07 6.25034029756816e-07 765 1620.36363636364 1089 3.35578962148736e-08 410 1.79584334644036 -1.65485007866672 -1 11.9112517257596 765 1677 2324 3287 2715 431 634 410 3886 1089 606 740 M12613 GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTRATE_INDEPENDENT_TELENCEPHALIC_TANGENTIAL_MIGRATION.html The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. 8/21 Gene Ontology BP GO:0021826 5.91270615643762e-07 9.05291929776382e-07 985 1465.09090909091 1090 5.91270772964244e-08 40 3.65563553398908 4.4795987018089 1 23.7290447532733 985 2066 4377 1147 3054 1090 522 89 40 1033 1713 741 M11066 GO_RESPONSE_TO_PHENYLPROPANOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PHENYLPROPANOID.html Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin. 10/17 Gene Ontology BP GO:0080184 2.42285958718483e-07 4.50402143794288e-07 605 1156.90909090909 1091 2.20259986728578e-08 365 5.06943662437475 -5.06943662437475 -1 34.6086609218298 603 1091 903 721 2459 1261 1496 1138 617 2072 365 742 M10648 GO_EMBRYONIC_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. 32/46 Gene Ontology BP GO:0000578 1.87320602502391e-08 1.97691467186943e-07 2085 1112.09090909091 1093 1.70291458270315e-09 96 2.32871510767439 -2.04570041406796 -1 16.7355773275715 2081 569 1306 183 96 1575 2361 1402 487 1080 1093 743 M14259 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor. 27/47 Gene Ontology BP GO:0010574 4.46897737454073e-08 1.97691467186943e-07 700 1181.36363636364 1093 4.06270678665588e-09 149 2.40206611709957 2.18721968486288 1 17.2662851480858 697 742 1093 1191 877 766 149 1848 2893 1233 1506 744 M15727 GO_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMPORT_INTO_CELL.html The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 35/59 Gene Ontology BP GO:0098657 5.37177149283793e-08 2.05087954115883e-07 3335 1688.45454545455 1093 4.88342874909203e-09 495 2.93020914917842 -2.70708315772667 -1 21.0370486018701 3331 513 526 495 1093 3536 3909 1513 572 670 2415 745 M16286 GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. 65/98 Gene Ontology BP GO:0003143 5.37292533993686e-08 2.05087954115883e-07 1715 1173.18181818182 1095 4.88447770105139e-09 187 2.0490207865259 2.28590752917472 1 14.6766620818389 1714 236 1050 1171 1095 1312 2396 1726 1085 933 187 746 M16274 GO_REGULATION_OF_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FILOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 51/68 Gene Ontology BP GO:0051489 4.34359221747989e-08 1.97691467186943e-07 2045 1513.45454545455 1096 3.94872027567097e-09 330 2.39887822776914 2.70632491264634 1 17.2432201921724 2041 348 1096 475 834 3026 3139 1087 330 1411 2861 747 M12946 GO_RESPONSE_TO_AMPHETAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMPHETAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. 27/46 Gene Ontology BP GO:0001975 6.57893586416508e-08 2.17413460714792e-07 1420 1117.63636363636 1098 5.98085096445749e-09 300 2.45333179770637 2.26478573208077 1 17.5278550366087 1417 682 1535 606 1302 1098 782 300 320 2210 2042 748 M13471 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation. 25/54 Gene Ontology BP GO:0046641 6.64107315769404e-07 9.96803658153238e-07 130 1664.36363636364 1098 6.03734105674134e-08 127 1.51579629416737 -1.54477245215599 -1 9.70454729725239 127 688 2422 2342 3064 514 893 1005 4243 1912 1098 749 M14332 GO_MECHANORECEPTOR_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANORECEPTOR_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. 61/96 Gene Ontology BP GO:0042490 7.37602736192172e-08 2.26660262109249e-07 2015 1243.90909090909 1098 6.70547964474614e-09 284 2.49909625068088 2.63612726964087 1 17.8081415922 2013 284 1009 612 1420 1516 2303 2473 591 1098 364 750 M15895 GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling. 23/31 Gene Ontology BP GO:0050849 5.39025946854816e-08 2.05244495148564e-07 1050 1558.54545454545 1098 4.90023600055988e-09 552 1.95651729778951 2.26446425241565 1 14.0082754741005 1048 796 2269 3072 1098 1039 1567 566 3197 1940 552 751 M12549 GO_PROTEIN_HETEROTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTRIMERIZATION.html The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. 27/31 Gene Ontology BP GO:0070208 0.000112915464893999 0.000118948530258497 60 1559.36363636364 1100 1.02655691564146e-05 57 3.79480499848392 3.92042443121901 1 15.9601632991385 57 2762 581 1772 4402 909 784 2271 974 1541 1100 752 M13066 GO_MIDDLE_EAR_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDDLE_EAR_MORPHOGENESIS.html The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). 19/30 Gene Ontology BP GO:0042474 1.31491225571449e-06 1.77667848457105e-06 705 1527.18181818182 1103 1.1953754923833e-07 443 3.36220183528635 3.7637397936375 1 20.7527375299341 704 2837 1103 2378 3408 939 443 507 1949 1666 865 753 M14731 GO_BEHAVIORAL_RESPONSE_TO_COCAINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_BEHAVIORAL_RESPONSE_TO_COCAINE.html Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. 8/15 Gene Ontology BP GO:0048148 1.55305109680126e-09 2.81180807525926e-08 630 1300.27272727273 1104 1.55305109788665e-10 1 4.20677427903413 5.22052776950934 1 34.1691358407726 628 1104 4515 558 2707 1304 1279 1 188 1522 497 754 M16481 GO_DEVELOPMENTAL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. 228/357 Gene Ontology BP GO:0021700 9.69477964640843e-10 1.84121672223422e-08 1575 1057.36363636364 1104 8.81343604607334e-11 181 2.49336421020437 2.79898719526815 1 20.7008641440193 1572 1421 181 450 763 590 1646 2543 1104 236 1125 755 M11398 GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of T cell proliferation. 77/158 Gene Ontology BP GO:0042102 1.19742031684115e-07 2.84948968717509e-07 635 1326.18181818182 1106 1.08856398364962e-08 187 1.95279146807538 -1.69187408617865 -1 13.6810724828939 632 187 1319 1516 1895 458 1106 2127 3759 858 731 756 M13605 GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_LINOLENIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 17/20 Gene Ontology BP GO:0036109 1.45920003401223e-08 1.97691467186943e-07 860 1500.81818181818 1107 1.32654549426428e-09 30 1.57930064924484 -1.272059050076 -1 11.3134281709103 1107 890 2506 3300 30 858 363 1357 2643 2597 858 757 M13865 GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. 15/15 Gene Ontology BP GO:0051988 1.47649512790634e-06 1.96626554955587e-06 410 1275.90909090909 1107 1.34226919893961e-07 407 2.0131142116282 2.38384099342519 1 12.2846279546291 407 897 2012 1217 3464 931 1492 672 494 1342 1107 758 M12267 GO_ECTODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. 28/39 Gene Ontology BP GO:0007398 2.40627196009206e-07 4.48393409303499e-07 1095 1426.72727272727 1108 2.18752020298227e-08 157 2.41977403801572 -2.08388552034207 -1 16.4655708796535 1095 1850 1445 1498 2452 1004 421 157 3846 1108 818 759 M11632 GO_CARTILAGE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARTILAGE_MORPHOGENESIS.html The process in which the anatomical structures of cartilage are generated and organized. 13/20 Gene Ontology BP GO:0060536 1.82877096233538e-07 3.74692703115214e-07 1310 1284.90909090909 1109 1.66251919486702e-08 265 3.84090312326446 4.08447280199622 1 26.5254551519537 1308 2527 1041 837 2228 1023 265 1670 1109 1329 797 760 M13691 GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that modulates the frequency, rate or extent of regulated secretory pathway. 117/188 Gene Ontology BP GO:1903305 5.53481648938633e-08 2.05617623085131e-07 1310 1031.27272727273 1109 5.03165148057516e-09 14 2.21208969170895 -2.01487641442907 -1 15.8510134141637 1310 14 785 1109 1127 726 1500 1546 1037 794 1396 761 M12011 GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION.html Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. 14/24 Gene Ontology BP GO:0071675 8.08970629802049e-07 1.17482532474062e-06 850 1298.90909090909 1110 7.35428115701787e-08 304 3.55376247370206 3.40000582263079 1 22.6305254651926 849 2012 613 758 3169 1541 1699 304 1110 842 1391 762 M11093 GO_OOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OOGENESIS.html The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. 63/107 Gene Ontology BP GO:0048477 2.10026545943675e-07 4.10371103569752e-07 1115 1181.09090909091 1111 1.90933241812909e-08 296 2.5815964835173 2.44559411862096 1 17.6814872242608 1111 296 1011 960 2338 1165 816 1420 478 1240 2157 763 M14622 GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of guanylate cyclase activity. 7/14 Gene Ontology BP GO:0031282 1.05039138068959e-07 2.64657043934525e-07 1030 1467.81818181818 1112 1.05039143033909e-08 84 2.78196719805419 -2.74318218820608 -1 19.6345492162213 1029 1112 4505 231 1858 1128 1009 84 3369 1216 605 764 M10400 GO_PIGMENT_GRANULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_LOCALIZATION.html Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. 25/29 Gene Ontology BP GO:0051875 3.68575187896991e-07 6.24537636301784e-07 1420 1255.90909090909 1113 3.35068408769042e-08 145 2.30888332135813 -2.15635486352934 -1 15.3472507458337 1416 738 1861 565 2713 1596 1010 1071 145 1587 1113 765 M12585 GO_CEREBELLAR_CORTEX_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 62/95 Gene Ontology BP GO:0021695 8.01930349873963e-08 2.35520479581606e-07 1690 1136.72727272727 1113 7.29027617368574e-09 273 2.8154481032254 3.08141853246523 1 20.026127223924 1687 294 727 473 1498 1275 1113 2497 273 1973 694 766 M15950 GO_RESPONSE_TO_NUTRIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NUTRIENT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. 226/310 Gene Ontology BP GO:0007584 1.85885474121132e-12 5.70750410193946e-11 965 1028.63636363636 1114 1.68986794655718e-13 107 2.67982234424262 2.92530108651485 1 29.5127823638504 965 1436 107 529 415 1114 1691 1329 1543 280 1906 767 M16939 GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of cell proliferation. 749/1017 Gene Ontology BP GO:0008285 4.72082807146709e-08 1.98252330758246e-07 1115 1469.63636363636 1114 4.72082817175507e-09 450 2.18775429458168 2.46041873352766 1 15.7127953131921 1114 1216 4653 1474 1050 664 1484 958 2213 450 890 768 M14989 GO_LYTIC_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYTIC_VACUOLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. 63/73 Gene Ontology BP GO:0080171 1.25681035852319e-08 1.90486599290176e-07 1850 1489.27272727273 1121 1.14255487791188e-09 17 1.44936222789232 -1.27670675896553 -1 10.3985205195724 1848 273 3286 2336 17 505 1121 880 3402 2543 171 769 M16410 GO_LYSOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. 63/73 Gene Ontology BP GO:0007040 1.25681035852319e-08 1.90486599290176e-07 1125 1512.09090909091 1122 1.14255487791188e-09 18 1.44936222789232 -1.27670675896553 -1 10.3985205195724 1849 274 3287 2337 18 506 1122 1121 3403 2544 172 770 M15749 GO_LIPID_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_LOCALIZATION.html Any process in which a lipid is transported to, or maintained in, a specific location. 236/373 Gene Ontology BP GO:0010876 3.86815190341757e-08 1.97691467186943e-07 1130 1186.90909090909 1128 3.51650179220853e-09 286 2.51764834618671 -2.43169619681102 -1 18.1025434814027 1128 2147 327 1097 697 1190 2310 1317 1770 286 787 771 M11861 GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 66/115 Gene Ontology BP GO:0033555 9.48511100773167e-08 2.5233974567739e-07 975 1282.72727272727 1129 8.62282856061284e-09 69 3.23012372468046 3.59780378708598 1 22.8879181762324 975 2673 470 2077 1683 1403 1744 69 977 1129 910 772 M14286 GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE.html Any process in by an organism or tissue maintains a population of neuronal stem cells. 30/36 Gene Ontology BP GO:0097150 5.55948441146031e-08 2.05617623085131e-07 4365 1922.18181818182 1130 5.05407686540966e-09 117 2.72374049898558 3.12740578135956 1 19.5434723411981 4363 587 966 600 1130 3723 2937 1042 117 1645 4034 773 M16940 GO_REGULATION_OF_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of T cell migration. 18/35 Gene Ontology BP GO:2000404 1.899437772255e-07 3.83772067845974e-07 1210 1292.27272727273 1130 1.72676176022621e-08 164 2.57878807494997 -2.50082353571483 -1 17.7431272253426 1209 1952 1130 729 2263 606 164 3651 564 679 1268 774 M15401 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING.html The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. 7/13 Gene Ontology BP GO:0034374 2.31181832508582e-08 1.97691467186943e-07 2595 1577.63636363636 1132 2.31181834913609e-09 240 4.63476985512707 -4.37715649799672 -1 33.4203005317618 2595 1111 4552 744 275 2434 1132 268 240 1217 2786 775 M14610 GO_REGULATION_OF_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROVILLUS_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. 24/32 Gene Ontology BP GO:0032530 1.39518570514851e-07 3.11452674737746e-07 3365 1641.54545454545 1133 1.26835072147978e-08 129 2.95758420312547 -3.78606898510537 -1 20.6554611552352 3362 698 935 419 2027 4266 3189 458 129 1133 1441 776 M11140 GO_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_SIGNALING.html Any process that mediates the transfer of information from one cell to another. 571/1050 Gene Ontology BP GO:0007267 1.96529183460047e-30 1.30635755805657e-27 5 1100.18181818182 1134 1.96529183460045e-31 1 2.71258875993774 3.05483402059032 1 78.5899312517434 1134 1231 4279 1 206 192 1848 1556 1155 5 495 777 M12132 GO_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_AGING.html A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). 324/435 Gene Ontology BP GO:0007568 4.21605821217843e-08 1.97691467186943e-07 1125 1293.54545454545 1134 3.83278026634049e-09 443 2.34234098568591 2.57999527893804 1 16.834163019558 1121 2602 443 1039 794 1134 1582 1455 1881 625 1553 778 M12161 GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 5/10 Gene Ontology BP GO:0046133 5.25673796754262e-07 8.23001405214529e-07 1610 1602.45454545455 1134 5.25673921104125e-08 76 2.99290926516657 3.55341226979977 1 19.5404133754514 1609 1127 4348 1134 4036 1409 755 76 207 1802 1124 779 M12991 GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity. 34/68 Gene Ontology BP GO:0001914 4.10592973625442e-07 6.76998265867889e-07 195 1640.09090909091 1134 3.73266409323392e-08 194 1.47117050318973 -1.42108773869046 -1 9.68228525148786 194 547 2627 2811 2785 389 211 693 4494 2156 1134 780 M11277 GO_PH_REDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PH_REDUCTION.html Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. 40/49 Gene Ontology BP GO:0045851 5.57463712033349e-08 2.05617623085131e-07 75 1067.54545454545 1135 5.06785205599153e-09 45 1.80421702709788 -1.6547260927519 -1 12.9074959993222 73 1773 2534 2714 1135 51 45 124 1176 1981 137 781 M13111 GO_OPTIC_NERVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OPTIC_NERVE_DEVELOPMENT.html The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. 18/26 Gene Ontology BP GO:0021554 4.99991922444444e-08 2.02125318430408e-07 1170 1109.18181818182 1136 4.54538121643377e-09 81 2.54049208016154 2.66019791936738 1 18.241411040032 1169 880 1709 294 1011 1897 1556 579 81 1889 1136 782 M13078 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of multicellular organismal development. 1657/2329 Gene Ontology BP GO:2000026 5.4951418302564e-26 1.96683807201408e-23 930 1215.63636363636 1138 5.49514183025643e-27 3 2.31006093103913 2.56715873497446 1 56.4955915886387 928 1138 4405 3 498 691 1538 1141 1783 9 1238 783 M14014 GO_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYSTEM_PROCESS.html A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. 1143/2821 Gene Ontology BP GO:0003008 5.60706211305622e-29 3.26120750150633e-26 1050 1216.72727272727 1139 5.6070621130562e-30 6 2.55579443280942 2.85923629312167 1 70.1864927855999 1046 1162 4465 328 598 527 1504 1200 1409 6 1139 784 M13728 GO_FEMALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_SEX_DIFFERENTIATION.html The establishment of the sex of a female organism by physical differentiation. 120/166 Gene Ontology BP GO:0046660 4.51521259343801e-08 1.97760774550163e-07 1960 1486.18181818182 1142 4.10473880555169e-09 30 2.57995920984329 2.72612367488864 1 18.5529499858559 1957 30 464 1142 900 1243 1022 4234 1255 1003 3098 785 M10795 GO_MALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. 13/30 Gene Ontology BP GO:0030539 7.72268625019615e-07 1.12856969604782e-06 2315 1381.36363636364 1143 7.02062632827387e-08 199 2.63285908026552 3.27167046027097 1 16.7864311954375 2314 967 1143 199 3150 2072 1808 1340 500 956 746 786 M13623 GO_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that modulates the frequency, rate or extent of reproductive process. 121/184 Gene Ontology BP GO:2000241 4.76848467463985e-08 1.98252330758246e-07 1520 1608.54545454545 1143 4.33498616181494e-09 487 2.52956667383107 2.77619845442912 1 18.1854158225702 1519 1607 487 1143 972 1077 1125 3274 3174 691 2625 787 M14292 GO_NEUTRAL_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. 71/116 Gene Ontology BP GO:0006638 3.29981124313845e-08 1.97691467186943e-07 1025 1510.18181818182 1143 2.99982844784799e-09 517 1.90809783617537 -1.94263963043803 -1 13.6923352893611 1022 1695 1904 3861 517 667 1143 853 2818 1326 806 788 M16562 GO_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. 1469/2129 Gene Ontology BP GO:0009888 8.54616904343988e-32 7.95306491182515e-29 925 1327.18181818182 1143 8.54616904343982e-33 3 2.45688412473562 2.71383268377261 1 74.3939469910737 921 1143 4635 1272 515 290 1481 1269 2267 3 803 789 M13039 GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FIBROBLAST_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. 123/171 Gene Ontology BP GO:0071774 6.58657690647554e-08 2.17413460714792e-07 285 1132.90909090909 1145 5.9877973669736e-09 284 2.33741491046435 2.86392125110557 1 16.6943418815683 284 2209 965 2143 1307 312 526 1273 1145 1862 436 790 M14458 GO_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DIFFERENTIATION.html The establishment of the sex of an organism by physical differentiation. 281/438 Gene Ontology BP GO:0007548 6.35183836212448e-08 2.14167419557719e-07 960 1343.45454545455 1145 5.77439867774066e-09 372 2.36813755609472 2.45052155128612 1 16.9319533517075 957 2989 542 1508 1273 372 585 2690 1670 1047 1145 791 M14504 GO_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 468/671 Gene Ontology BP GO:0008610 2.90580555353062e-08 1.97691467186943e-07 810 1378.45454545455 1146 2.64164144719192e-09 370 1.89167653223038 -1.90459173001297 -1 13.5735241851249 807 1287 1656 3264 390 370 1146 1096 1896 2123 1128 792 M13843 GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHRONIC_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. 5/11 Gene Ontology BP GO:0002676 5.78252478378305e-07 8.89751581314237e-07 1150 1512.81818181818 1149 5.78252628847528e-08 103 3.83505518983137 -4.04984592546552 -1 24.9303481674807 1149 1119 4453 240 3044 1456 1971 251 103 1077 1778 793 M11237 GO_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_TRANSPORT.html The directed movement of substances into, out of or within a vacuole. 290/316 Gene Ontology BP GO:0007034 3.59834233877817e-08 1.97691467186943e-07 285 1912.63636363636 1150 3.27122036148458e-09 16 1.14836454614482 -1.14475197154452 -1 8.19552751965367 281 1390 4170 4415 620 16 441 1150 3758 4423 375 794 M16044 GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 14/17 Gene Ontology BP GO:0060547 3.81126106766151e-07 6.39563786070615e-07 1150 1140.36363636364 1150 3.46478338901933e-08 80 2.16361014429581 -2.76077287439325 -1 14.3503875867446 1150 933 1682 1152 2738 740 188 2114 80 1534 233 795 M13152 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 1392/1994 Gene Ontology BP GO:0051240 1.77413578076867e-23 3.43960574496525e-21 1130 1468.81818181818 1151 1.77413578076867e-24 13 2.34903764496854 2.57279173914919 1 51.7650323512657 1126 1151 4412 873 678 1045 1788 1159 2044 13 1868 796 M10035 GO_LACTATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSPORT.html The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 12/13 Gene Ontology BP GO:0015727 5.65269990824109e-08 2.06162496199217e-07 2140 1416.81818181818 1152 5.13881823043824e-09 199 2.97389682553457 2.38146232506841 1 21.3451006601588 2136 998 799 1834 1152 2695 2807 199 463 556 1946 797 M13665 GO_LACTATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. 12/13 Gene Ontology BP GO:0035873 5.65269990824109e-08 2.06162496199217e-07 2140 1415.09090909091 1153 5.13881823043824e-09 170 2.97389682553457 2.38146232506841 1 21.3451006601588 2137 999 800 1835 1153 2696 2808 170 464 557 1947 798 M15575 GO_ENDOCHONDRAL_BONE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_BONE_MORPHOGENESIS.html The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. 59/74 Gene Ontology BP GO:0060350 1.49518536422338e-07 3.25796071963426e-07 625 1338.27272727273 1153 1.35925951440057e-08 555 2.76167342769783 3.19246903188488 1 19.2214692816045 624 1712 555 1052 2082 1153 1493 2408 1512 1122 1008 799 M10497 GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH.html The activation of endogenous cellular processes that result in the death of a cell as part of its development. 31/41 Gene Ontology BP GO:0010623 1.78372859883073e-06 2.31702237076397e-06 1155 1486.18181818182 1155 1.62157276823096e-07 366 2.43361132153569 2.59763839651668 1 14.6870183319477 1155 2748 1889 864 3551 550 464 1172 511 3078 366 800 M15705 GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYE_PHOTORECEPTOR_CELL_DEVELOPMENT.html Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. 26/55 Gene Ontology BP GO:0042462 2.15185299748836e-06 2.74317041022283e-06 1060 1281 1157 1.95623191113721e-07 335 2.56293260027039 2.89400251520474 1 15.2706814455753 1059 725 1196 1541 3620 997 851 335 1214 1396 1157 801 M10038 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_VISUAL_PERCEPTION.html The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. 20/46 Gene Ontology BP GO:0050908 2.88274027303478e-08 1.97691467186943e-07 2080 1295.09090909091 1158 2.6206730098258e-09 243 2.86586714668426 3.00085000034381 1 20.6219694868843 2077 806 956 1310 379 2337 3099 626 243 1158 1255 802 M13778 GO_ADRENAL_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENAL_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. 17/28 Gene Ontology BP GO:0030325 3.97510685026856e-08 1.97691467186943e-07 1160 1194.72727272727 1158 3.61373356553949e-09 32 2.60990446223636 3.19076448707343 1 18.7700331677956 1158 872 1252 105 730 2278 2996 1204 32 1700 815 803 M15406 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 1207/1669 Gene Ontology BP GO:0051094 1.62453577790406e-20 1.8897412436469e-18 970 1285.18181818182 1158 1.62453577790407e-21 6 2.39588928092703 2.62950340485222 1 45.7151479193333 968 1158 4553 6 621 757 1550 1508 1454 20 1542 804 M11817 GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESONEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 20/33 Gene Ontology BP GO:0061217 1.3752843528837e-07 3.09289419718117e-07 2390 1365.36363636364 1161 1.25025858077886e-08 389 2.71171935212441 2.93439259447734 1 18.93782344592 2389 818 899 549 2012 1824 890 2711 389 1161 1377 805 M14779 GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. 20/46 Gene Ontology BP GO:0050962 2.88274027303478e-08 1.97691467186943e-07 2080 1297.27272727273 1163 2.6206730098258e-09 244 2.86586714668426 3.00085000034381 1 20.6219694868843 2078 807 957 1311 380 2338 3100 636 244 1163 1256 806 M14159 GO_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 1127/1567 Gene Ontology BP GO:0009628 3.29066967866391e-08 1.97691467186943e-07 1400 1394.09090909091 1167 3.29066972739219e-09 227 2.17969532147932 2.3926775782746 1 15.6573922205793 1396 1167 4477 901 624 363 1870 1214 2064 227 1032 807 M14816 GO_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_DISASSEMBLY.html A process that results in the breakdown of the extracellular matrix. 70/149 Gene Ontology BP GO:0022617 7.3891736538633e-11 1.71053855778238e-09 2445 1589.27272727273 1169 6.71743059464678e-12 150 3.20491393072971 3.3054923826011 1 30.2101281391031 2444 188 150 676 1169 3296 3798 1831 701 275 2954 808 M11385 GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 79/160 Gene Ontology BP GO:0001676 1.79755571575158e-08 1.97691467186943e-07 1075 1302.90909090909 1170 1.63414157312626e-09 79 2.17295815671578 -2.12816164053776 -1 15.6086476149341 1071 182 945 2229 79 905 1170 1890 3205 1219 1437 809 M15639 GO_CELLULAR_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 25/29 Gene Ontology BP GO:0071305 1.24506975791649e-07 2.90828794356699e-07 1175 1383.18181818182 1171 1.1318816621637e-08 422 3.00477915828683 2.89672161310742 1 21.0833605270625 1171 732 527 3597 1929 1217 422 618 2234 640 2128 810 M10621 GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 54/68 Gene Ontology BP GO:0010718 1.23262683617036e-06 1.68391446526737e-06 1150 1469.45454545455 1172 1.12057047890285e-07 362 2.44386200685249 3.20960540280066 1 15.1149417368261 1148 362 992 1067 3371 1444 1749 1653 1172 2474 732 811 M16857 GO_REGULATION_OF_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. 663/834 Gene Ontology BP GO:0022604 2.88299070135147e-10 5.96202477039484e-09 980 1376.54545454545 1172 2.88299070172549e-11 107 2.2636115177548 2.62580018892164 1 19.9792929895029 979 1219 4649 364 561 1172 1867 1458 1156 107 1610 812 M16868 GO_CELLULAR_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 37/52 Gene Ontology BP GO:0071312 3.06012339768988e-07 5.38530793095727e-07 1175 1223.45454545455 1173 2.78193074849316e-08 301 2.62674069497128 2.97171615208339 1 17.6580506267207 1424 1795 1048 1173 2605 1007 825 1491 614 1175 301 813 M16513 GO_POLYOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 31/43 Gene Ontology BP GO:0046173 9.80160698929475e-08 2.56809599576163e-07 595 1240.72727272727 1174 8.9105522054395e-09 157 2.41786380884686 -2.64572546550643 -1 17.0840916433824 1693 595 1399 1838 1710 1174 1158 591 157 2469 864 814 M15718 GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of smoothened signaling. 27/42 Gene Ontology BP GO:0045880 1.29715310437855e-08 1.92832376826627e-07 1195 1075.54545454545 1175 1.17923010184251e-09 21 2.62861642791621 2.23900083215345 1 18.9360785991211 1195 692 1126 1854 21 1211 311 894 1175 1544 1808 815 M10268 GO_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. 951/1356 Gene Ontology BP GO:0060429 1.85051492733677e-21 2.60922604754484e-19 1395 1319.90909090909 1176 1.85051492733677e-22 4 2.5491382527975 2.80012445210152 1 51.0121274359129 1395 1176 4234 4 357 240 1976 2074 2099 16 948 816 M11734 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 71/88 Gene Ontology BP GO:0001837 1.50158591089957e-07 3.26642320870299e-07 1180 1214.27272727273 1176 1.36507819398971e-08 238 2.46002031880037 2.91287942624287 1 17.1065948249207 1541 238 615 618 2086 1179 911 2373 1597 1023 1176 817 M14099 GO_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. 961/1416 Gene Ontology BP GO:0006629 2.08919269756163e-08 1.97691467186943e-07 1000 1471.81818181818 1178 2.0891927172029e-09 192 1.9581564213212 -1.8708894827819 -1 14.0545182072099 999 1178 4473 2685 192 330 1469 984 1914 757 1209 818 M15121 GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_INDEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 38/55 Gene Ontology BP GO:0002756 9.67704210862566e-06 1.11249535069512e-05 205 1552 1180 8.79734970442029e-07 106 1.94044693801355 -2.02070171759829 -1 10.2609021198596 203 2727 2387 1627 4020 356 106 908 1180 2672 886 819 M15117 GO_EPITHELIAL_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MORPHOGENESIS.html The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. 53/69 Gene Ontology BP GO:0003382 2.14270499342076e-07 4.15243912302656e-07 2970 1781.09090909091 1181 1.94791382010091e-08 347 2.7492776527971 -2.80911922164739 -1 18.8220792836706 2969 1728 656 885 2359 4124 3533 1058 347 752 1181 820 M15775 GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 116/203 Gene Ontology BP GO:0043271 2.99963271814062e-08 1.97691467186943e-07 1185 1095.09090909091 1184 2.72693887185428e-09 47 2.27884831487166 2.27348521335376 1 16.3747820620154 1229 47 823 1184 409 609 1184 2591 1690 612 1668 821 M10809 GO_NEURON_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. 44/65 Gene Ontology BP GO:0042551 5.17239588198099e-08 2.03786266205398e-07 1355 1233.54545454545 1185 4.70217818508055e-09 418 2.58901241297938 2.77924339419876 1 18.5820290742521 1353 435 870 533 1046 1185 1906 2700 418 1401 1722 822 M11296 GO_INORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ANION_TRANSPORT.html The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 81/147 Gene Ontology BP GO:0015698 5.24567171613915e-08 2.04423035973161e-07 3395 1801.36363636364 1185 4.76879258292433e-09 138 2.47084905519899 -2.53311177324348 -1 17.7251644279869 3394 138 371 1100 1065 3022 3429 3160 1185 232 2719 823 M11972 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. 73/145 Gene Ontology BP GO:0002718 1.39059470413189e-06 1.86575465926346e-06 275 1413 1185 1.26417780282872e-07 205 1.91138188577956 -1.79464157622672 -1 11.7051182277494 274 205 1185 1561 3436 399 1908 2094 2995 878 608 824 M12884 GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. 52/73 Gene Ontology BP GO:0019935 5.81710009038877e-08 2.0762333639785e-07 480 1368.81818181818 1185 5.28827294927349e-09 429 2.63879148108746 3.13619233432079 1 18.9184098983865 479 3055 812 2282 1185 783 429 1187 2519 945 1381 825 M11822 GO_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_PROLIFERATION.html The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 69/97 Gene Ontology BP GO:0072089 3.23969546507312e-07 5.62264192427647e-07 760 1285.90909090909 1188 2.94517812922469e-08 223 2.43626825954194 2.93285940091087 1 16.3201677020881 757 2672 1288 1557 2639 539 953 354 1975 1188 223 826 M13098 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion. 11/17 Gene Ontology BP GO:2000778 1.95375466991155e-06 2.51127637544156e-06 990 1759.81818181818 1188 1.77614218635019e-07 443 1.58302870951003 1.58478547081275 1 9.45442727742043 988 1081 2759 2564 3586 1188 702 646 2061 3340 443 827 M13346 GO_CARDIAC_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CELL_FATE_COMMITMENT.html The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. 7/19 Gene Ontology BP GO:0060911 2.20086514846623e-08 1.97691467186943e-07 2455 1663.63636363636 1189 2.20086517026336e-09 9 3.87283910497941 5.41623885727844 1 27.9075937406427 2451 1108 4422 144 1189 3219 3427 9 26 1214 1091 828 M12574 GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INCREASED_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. 38/49 Gene Ontology BP GO:0036296 3.9220294850246e-06 4.72899797714939e-06 125 1480.45454545455 1190 3.56548770636686e-07 123 2.77206410695584 3.04496392870108 1 15.8183893879244 123 2321 896 1798 3830 732 638 2115 1190 1761 881 829 M15782 GO_RESPONSE_TO_HYPEROXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYPEROXIA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. 38/49 Gene Ontology BP GO:0055093 3.9220294850246e-06 4.72899797714939e-06 125 1482.27272727273 1191 3.56548770636686e-07 124 2.77206410695584 3.04496392870108 1 15.8183893879244 124 2322 897 1799 3831 733 639 2118 1191 1769 882 830 M15679 GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 177/308 Gene Ontology BP GO:0006140 2.07158836004555e-08 1.97691467186943e-07 1300 1459 1192 1.88326216322934e-09 135 2.18408461489614 2.43672336624288 1 15.689149552361 1297 2618 923 1603 135 324 1192 3074 3338 579 966 831 M10213 GO_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 53/102 Gene Ontology BP GO:0051339 2.89236467510178e-08 1.97691467186943e-07 1935 1420 1193 2.62942246648002e-09 369 2.53507860608947 2.61366819919517 1 18.2286545644877 1934 369 1086 1515 386 1076 1471 2670 2753 1193 1167 832 M16739 GO_METANEPHROS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHROS_MORPHOGENESIS.html The process in which the anatomical structures of the metanephros are generated and organized. 21/38 Gene Ontology BP GO:0003338 2.86943518401663e-07 5.12237441465487e-07 1260 1258.27272727273 1194 2.608577780249e-08 579 2.61402051832188 2.66279709062079 1 17.633321831139 1258 772 863 579 2564 1257 1630 2291 636 797 1194 833 M16086 GO_BASEMENT_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASEMENT_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. 28/31 Gene Ontology BP GO:0071711 2.34283168494014e-06 2.9598685392415e-06 25 1463.72727272727 1197 2.12984925443669e-07 22 3.47992492033509 3.73981914912553 1 20.6508377596845 22 2346 367 1344 4394 1116 1197 2255 882 731 1447 834 M13064 GO_PREPULSE_INHIBITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREPULSE_INHIBITION.html The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. 11/22 Gene Ontology BP GO:0060134 3.85294632902306e-07 6.44651537898032e-07 1485 1491.81818181818 1198 3.50267909436803e-08 340 2.47498906020329 2.4279003955107 1 16.4227282395955 1484 1035 1433 1198 2746 1064 340 4026 392 1785 907 835 M15761 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 184/249 Gene Ontology BP GO:0007163 1.82365140033016e-08 1.97691467186943e-07 1200 1189.54545454545 1198 1.65786492313363e-09 87 1.99046697912238 2.32550482500757 1 14.2882909370556 1198 1497 1533 191 87 1111 1651 2596 925 952 1344 836 M11091 GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme adenylate cyclase. 25/45 Gene Ontology BP GO:0007190 4.51119286910981e-08 1.97760774550163e-07 1200 1525.81818181818 1200 4.10108451055792e-09 235 1.9763371006951 2.124181799797 1 14.1857340161445 1200 778 2390 2382 899 767 463 1664 3360 2646 235 837 M10979 GO_NOTCH_RECEPTOR_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_RECEPTOR_PROCESSING.html The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. 18/20 Gene Ontology BP GO:0007220 5.00876219234758e-07 7.90562092299637e-07 1205 1599 1204 4.55342121154352e-08 75 2.15313586954578 -1.39355090716617 -1 14.0664638026063 1204 857 2011 1577 2914 512 253 4466 75 2757 963 838 M11087 GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. 60/90 Gene Ontology BP GO:0046928 6.58828668832703e-08 2.17413460714792e-07 2380 1441.81818181818 1204 5.98935171420441e-09 265 2.05683625044517 2.34439319221935 1 14.676810098979 2379 265 1267 1013 1308 2158 3242 972 908 1204 1144 839 M14471 GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_ION_IMPORT.html Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle. 49/81 Gene Ontology BP GO:0090280 5.91900124724635e-08 2.08691925686504e-07 2250 1588.36363636364 1205 5.38091036954038e-09 107 2.67054340342654 2.44352629221687 1 19.1409856374375 2250 357 712 107 1205 2330 3252 3714 302 649 2594 840 M14618 GO_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. 25/33 Gene Ontology BP GO:0072215 9.14974604705357e-08 2.49206886189644e-07 1210 1446.27272727273 1207 8.31795129780845e-09 595 2.77620834415368 2.66432742303241 1 19.6719405374042 1207 1898 1215 595 1640 795 1053 4097 893 1915 601 841 M15889 GO_SKIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKIN_DEVELOPMENT.html The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. 246/353 Gene Ontology BP GO:0043588 8.40817903260078e-18 7.11331946158026e-16 1615 1258.09090909091 1207 7.64379912054617e-19 30 2.77126002820993 3.03694092439383 1 45.1917949661755 1615 1406 30 1682 329 1145 2492 1207 3056 104 773 842 M11727 GO_SPECIFICATION_OF_ORGAN_IDENTITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_ORGAN_IDENTITY.html The regionalization process in which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. 13/21 Gene Ontology BP GO:0010092 3.43966236386065e-06 4.18862836405224e-06 715 1622.09090909091 1211 3.12697067429607e-07 240 2.76500948331672 3.24679357435102 1 15.9350985936466 714 2913 1980 1666 3794 1059 704 240 1211 2787 775 843 M14615 GO_MUSCLE_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_FATE_COMMITMENT.html The process in which the cellular identity of muscle cells is acquired and determined. 5/19 Gene Ontology BP GO:0042693 1.14086879616661e-07 2.7691510216814e-07 2575 1751.27272727273 1211 1.14086885473779e-08 344 2.94293572558891 3.82582216208984 1 20.7147233744208 2572 1124 4504 1211 1937 2479 1104 1100 344 1803 1086 844 M14835 GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_INHIBITING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). 36/87 Gene Ontology BP GO:0007193 3.12239622066336e-07 5.47007139109437e-07 1095 1583.09090909091 1211 2.83854242165099e-08 59 2.61077788434236 2.86584722905412 1 17.5309441630492 1092 3091 1197 2271 2615 998 1211 258 2809 1813 59 845 M12505 GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of T cell tolerance induction. 24/53 Gene Ontology BP GO:0002664 1.33857976056676e-06 1.80396592783269e-06 115 1647.45454545455 1212 1.21689143183644e-07 112 1.50960895418662 -1.51801089232004 -1 9.24475567232661 112 726 2606 2360 3419 404 321 944 3138 2880 1212 846 M10878 GO_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. 7/16 Gene Ontology BP GO:0006182 7.50641933617267e-08 2.28689428729205e-07 180 1492.45454545455 1213 7.50641958973117e-09 1 2.82437072544657 2.82437072544657 1 20.1289150106037 176 2083 4268 2498 1535 152 1 584 3824 1213 83 847 M12102 GO_CELLULAR_RESPONSE_TO_ATP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ATP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. 17/23 Gene Ontology BP GO:0071318 2.23222390612545e-07 4.26727109087992e-07 560 1289.90909090909 1213 2.02929466601588e-08 226 1.80783680224181 1.91050089006518 1 12.314953051778 558 917 2383 1941 2391 522 479 1431 1213 2128 226 848 M15282 GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle development. 119/167 Gene Ontology BP GO:0048634 1.71182204851218e-07 3.57500358695115e-07 1745 1190 1214 1.55620198337202e-08 24 2.25848517942829 2.77062807727939 1 15.6003286823392 1743 24 920 304 2184 870 1214 1587 1606 1190 1448 849 M16365 GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 39/62 Gene Ontology BP GO:0021680 5.7793421031465e-08 2.07580109259326e-07 1930 1475.36363636364 1215 5.25394750451664e-09 477 2.95509959798587 3.3265822284781 1 21.1999775770974 1927 2320 1097 559 1178 1729 1123 1804 477 2800 1215 850 M15396 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. 27/46 Gene Ontology BP GO:0032736 4.45557666728473e-07 7.20604735240731e-07 95 1528.54545454545 1216 4.05052506332367e-08 93 1.58138388510893 -1.64884545173742 -1 10.3698433333989 93 651 2410 1581 2842 633 1044 909 3222 2213 1216 851 M13288 GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. 12/17 Gene Ontology BP GO:0030007 5.48838170857011e-07 8.51531846948207e-07 630 1677.27272727273 1218 4.98943916160689e-08 118 2.49774231867423 2.42347841934634 1 16.24890856335 629 1024 1218 1923 2963 488 118 3547 3720 1115 1705 852 M16721 GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of monocyte chemotaxis. 19/30 Gene Ontology BP GO:0090025 9.89236548146585e-07 1.39145031998974e-06 1220 1153.81818181818 1218 8.99306357236385e-08 136 3.26503678576379 3.28258844683882 1 20.523743689455 1218 819 658 136 3270 1546 1680 697 146 1298 1224 853 M13674 GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_13_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-13 production. 28/65 Gene Ontology BP GO:0032656 4.27811140214561e-07 6.96502881531964e-07 80 1522.36363636364 1219 3.88919294005973e-08 79 1.56122417494034 -1.62355331361809 -1 10.261098656094 79 630 2436 1934 2820 599 959 887 3198 1985 1219 854 M14200 GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS.html A multicellular organism process which involves another multicellular organism of the same or different species. 213/337 Gene Ontology BP GO:0044706 9.92493324991147e-10 1.86966455108656e-08 1220 1259.81818181818 1220 9.02266659489901e-11 183 2.54427789660719 2.59282446879054 1 21.1075943577289 1220 2153 183 909 404 889 1735 2317 1702 339 2007 855 M10316 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 62/84 Gene Ontology BP GO:0010518 9.03435166190748e-08 2.47858716290421e-07 2045 1423.63636363636 1223 8.21304730264118e-09 253 3.07012443575035 -3.20603844909202 -1 21.7743805856785 2042 301 479 805 1628 2342 3730 253 2092 765 1223 856 M11805 GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE.html An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. 17/108 Gene Ontology BP GO:0002251 1.39959764756206e-06 1.87621084820118e-06 450 1828.09090909091 1223 1.27236230723631e-07 446 2.93525958985789 -3.30750559815049 -1 18.0281413302402 446 3192 1223 2286 3439 1120 1177 975 3744 1316 1191 857 M11868 GO_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH.html Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. 683/998 Gene Ontology BP GO:0040008 3.41529002214583e-08 1.97691467186943e-07 1135 1392.63636363636 1223 3.41529007463475e-09 388 2.21070575849817 2.40092145700486 1 15.8817583414062 1135 1223 4328 489 663 1034 1631 1392 1674 388 1362 858 M13601 GO_REGULATION_OF_ODONTOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS.html Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth. 19/27 Gene Ontology BP GO:0042481 1.2415640330398e-07 2.90301379182623e-07 1225 1178.36363636364 1223 1.12869463918831e-08 28 3.43385327987143 4.156766583679 1 24.1130773040057 1223 1959 857 1129 2262 1125 1508 28 1420 1296 155 859 M12333 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS.html Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. 158/210 Gene Ontology BP GO:0090288 5.39941885470033e-08 2.05257319697064e-07 875 1336.90909090909 1224 4.90856271565206e-09 229 2.12386392524608 2.44484646025357 1 15.2160554830585 871 3328 1437 1224 1100 336 1326 691 2358 1806 229 860 M13257 GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of receptor activity. 49/62 Gene Ontology BP GO:2000273 1.6590165343517e-08 1.97691467186943e-07 1615 1302.18181818182 1225 1.50819686078392e-09 54 2.10198479475851 2.6648932551087 1 15.0951425039059 1612 365 1495 1159 54 2039 3109 904 1225 1054 1308 861 M16378 GO_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 268/370 Gene Ontology BP GO:0009612 5.2924624147897e-11 1.28259518833419e-09 1475 1026.09090909091 1225 4.81132946810638e-12 141 2.56454026804315 3.00080882697222 1 24.497332494734 1474 1391 141 548 1335 980 1601 1225 1509 249 834 862 M10286 GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_4_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-4 production. 34/68 Gene Ontology BP GO:0032673 9.68331888676264e-07 1.36825031218058e-06 425 1563.90909090909 1227 8.80302104444218e-08 422 1.74952420641188 -1.60023737895019 -1 10.9586520601308 422 545 2082 2345 3256 723 885 847 3005 1866 1227 863 M14126 GO_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_METABOLIC_PROCESS.html The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 194/392 Gene Ontology BP GO:0008202 1.42799436728468e-08 1.97691467186943e-07 1520 1236.72727272727 1227 1.29817670595784e-09 27 2.43787322290378 -2.27655230217206 -1 17.5253560351696 1518 2165 628 2228 27 528 1844 994 1244 1227 1201 864 M14468 GO_RESPONSE_TO_VITAMIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. 33/35 Gene Ontology BP GO:0033197 3.00226467871434e-06 3.69564485451265e-06 420 1466.27272727273 1227 2.72933525073635e-07 377 3.60679114078625 4.05370692227738 1 21.0325078426359 418 1826 377 1042 3779 1330 1227 2979 804 971 1376 865 M14783 GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. 25/31 Gene Ontology BP GO:0034394 4.30260922582593e-07 6.99759764112902e-07 835 1259.27272727273 1228 3.91146369754635e-08 27 2.63896857534207 3.15991135815315 1 17.4168444153877 835 2396 1802 591 2822 1270 1228 264 27 2285 332 866 M14938 GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_B_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase B. 27/37 Gene Ontology BP GO:0032148 2.72896487471142e-08 1.97691467186943e-07 3370 1963.27272727273 1229 2.48087718960232e-09 332 2.92246258020431 -2.8946218393314 -1 21.0314476850695 3369 727 1199 1056 332 3890 4267 2771 544 2212 1229 867 M14909 GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. 44/58 Gene Ontology BP GO:0031952 6.54128870237361e-08 2.1740440237246e-07 330 1085 1230 5.94662626987873e-09 108 2.12149054997908 2.35748333689776 1 15.1417553961737 330 1779 1945 1243 1296 219 108 788 1230 2479 518 868 M12230 GO_NEGATIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WOUND_HEALING.html Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 59/82 Gene Ontology BP GO:0061045 2.94666484947172e-13 1.07115871442124e-11 1330 1178.09090909091 1231 2.67878622679283e-14 46 3.53034671697566 3.46698488936345 1 41.6838318505576 1328 275 88 415 46 1885 2466 1231 2763 184 2278 869 M14101 GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROPHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. 16/18 Gene Ontology BP GO:0046475 1.81047210508783e-07 3.71974917693627e-07 1235 1435.18181818182 1231 1.64588386734471e-08 381 2.4559527488562 -2.07470979039189 -1 16.9285228251788 1231 914 1676 3036 2220 1335 1221 1506 1111 1156 381 870 M13507 GO_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASODILATION.html An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure. 27/34 Gene Ontology BP GO:0042311 1.07134829926122e-07 2.66909885512466e-07 970 1792.18181818182 1232 9.73953046757608e-09 166 2.9885871702268 3.57564000935881 1 21.0893568873092 969 4198 1232 4115 1797 418 166 863 3279 1873 804 871 M15149 GO_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 27/35 Gene Ontology BP GO:0046058 1.72954811960027e-06 2.25594243703297e-06 380 1783.90909090909 1234 1.57231770845478e-07 198 2.39916221438818 2.56174597258449 1 14.5075555933021 376 3707 1512 3305 3537 369 198 750 3492 1234 1143 872 M15272 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. 39/52 Gene Ontology BP GO:0001937 7.8483301930068e-07 1.14441492911503e-06 555 1524.72727272727 1234 7.13484817530856e-08 417 2.99512639769497 3.52862413534842 1 19.0921431040291 555 3084 1234 1929 3157 1220 1377 505 417 2496 798 873 M16165 GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. 42/59 Gene Ontology BP GO:0046622 1.30188587624804e-07 2.98996790828338e-07 1710 1347.54545454545 1234 1.18353268480842e-08 135 2.95933067252129 2.89902933796175 1 20.7243369740479 1710 437 649 207 1965 1234 1198 2562 135 1430 3296 874 M13212 GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLARIZED_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. 21/26 Gene Ontology BP GO:0030859 2.56414305156482e-07 4.6935317147644e-07 1450 1397.36363636364 1235 2.33103940947342e-08 287 3.41210592968248 4.30672994295581 1 23.191301535175 1449 789 869 739 2502 1547 1235 3480 287 1284 1190 875 M14879 GO_CELLULAR_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 156/199 Gene Ontology BP GO:0097306 7.31647239930877e-08 2.26202963946736e-07 1235 1331.36363636364 1235 6.65133876602769e-09 303 2.56358091868873 2.6460969220033 1 18.2729934822706 1235 1548 303 751 1411 1100 1039 2190 2290 400 2378 876 M15307 GO_DOPAMINERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. 27/46 Gene Ontology BP GO:0071542 1.12570786168615e-07 2.74557763766229e-07 1465 1344 1235 1.02337083571544e-08 707 2.40568617976718 2.70784871139151 1 16.9221267590689 1463 707 1405 1084 1840 1107 753 2530 1072 1235 1588 877 M12316 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. 127/212 Gene Ontology BP GO:1902107 6.10721287355546e-08 2.11120813526401e-07 885 1525.45454545455 1236 5.5520118573564e-09 17 1.95838093629782 -1.94467405410728 -1 13.995815393441 883 17 1360 2767 1236 1151 2561 1319 3513 741 1232 878 M16767 GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM.html A circulatory process that occurs at the level of the vasculature. 146/233 Gene Ontology BP GO:0003018 2.15774964077853e-11 5.51648850469368e-10 710 1266 1236 1.96159058254517e-12 132 2.92922273784972 3.08830838694882 1 29.155370912516 708 2626 132 1481 2516 478 1236 1561 1829 415 944 879 M10103 GO_REGULATION_OF_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GOLGI_ORGANIZATION.html Any process that modulates the frequency, rate or extent of Golgi organization. 19/19 Gene Ontology BP GO:1903358 8.84129158698017e-07 1.26970770846354e-06 1240 1488.45454545455 1238 8.03754103644812e-08 524 2.00321774355813 -2.06572842689079 -1 12.6343153723409 1238 2450 2685 1566 3209 603 524 797 641 2049 611 880 M14165 GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_PROJECTION_REGENERATION.html Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. 39/46 Gene Ontology BP GO:0070570 2.03759840087119e-08 1.97691467186943e-07 2965 1530.36363636364 1243 1.85236219976639e-09 131 2.80075767753799 3.51170464579709 1 20.1508907009721 2963 530 1243 838 131 2506 3410 1677 1143 1626 767 881 M10764 GO_RESPONSE_TO_CORTICOSTEROID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTEROID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 196/288 Gene Ontology BP GO:0031960 7.64995261393459e-13 2.59819193522902e-11 1245 1112.36363636364 1244 6.95450237630659e-14 5 2.6464968492563 2.71684491256443 1 30.1205353466156 1244 1476 96 513 5 788 1689 2693 1633 379 1720 882 M14226 GO_MONOSACCHARIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_TRANSPORT.html The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 55/83 Gene Ontology BP GO:0015749 5.72900391788396e-08 2.07125526261959e-07 2555 1339 1246 5.20818551552047e-09 147 2.63306053816543 -2.55204096884647 -1 18.8800397269821 2553 325 792 434 1168 2216 2869 1246 147 1368 1611 883 M15881 GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTEGRIN_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 110/141 Gene Ontology BP GO:0007229 4.6344503380373e-08 1.97760774550163e-07 270 1079.81818181818 1247 4.21313675969561e-09 249 2.63432395081236 2.71277362297152 1 18.9462797883119 266 1609 249 957 1678 1247 1499 1065 1438 365 1505 884 M13874 GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. 21/35 Gene Ontology BP GO:0034142 6.18597105342229e-07 9.38790714663207e-07 1565 1552.45454545455 1248 5.62361162981584e-08 787 2.32094538044829 -2.5305520322315 -1 14.9846369567472 1561 787 1206 1888 3025 1811 2877 1019 1248 795 860 885 M11069 GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that modulates the frequency, rate or extent of epithelial cell migration. 210/251 Gene Ontology BP GO:0010632 4.00379693283306e-08 1.97691467186943e-07 1250 1393.81818181818 1249 3.63981545972589e-09 440 2.29740171140741 2.41204949889332 1 16.5090192417868 1249 1460 440 779 735 1225 1424 2728 2175 737 2380 886 M10419 GO_ORGAN_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_REGENERATION.html The regrowth of a lost or destroyed organ. 92/128 Gene Ontology BP GO:0031100 2.10836938208717e-07 4.11158538761594e-07 935 1153.09090909091 1250 1.91669962194793e-08 139 2.14502198826073 2.28770930656441 1 14.6703127362822 935 139 1321 1312 2342 659 301 1250 692 1793 1940 887 M12087 GO_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_ADHESION.html The attachment of one cell to another cell via adhesion molecules. 571/888 Gene Ontology BP GO:0098609 3.07211190733881e-24 6.49751668402159e-22 1255 1494.81818181818 1251 3.07211190733881e-25 12 2.60226725502186 2.77600856202745 1 59.390215201589 1251 1229 4343 324 425 709 2033 2696 1695 12 1726 888 M12897 GO_RESPONSE_TO_GROWTH_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GROWTH_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. 34/67 Gene Ontology BP GO:0060416 1.87145260805682e-07 3.80672034126585e-07 950 1506.18181818182 1253 1.70132069750353e-08 239 1.85919063095594 -2.20044894539991 -1 12.7675078950042 947 1832 2559 1253 2245 1101 1905 239 1020 2832 635 889 M13153 GO_REGULATION_OF_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROTIC_CELL_DEATH.html Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents. 31/40 Gene Ontology BP GO:0010939 8.24788553768713e-08 2.37677062514889e-07 1275 1240.72727272727 1254 7.49807804263964e-09 209 1.88497925116665 -2.1909511108596 -1 13.3623231584404 1274 642 2245 2315 1533 704 331 1254 673 2468 209 890 M15683 GO_CARDIAC_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. 54/69 Gene Ontology BP GO:0060411 1.23642975966561e-07 2.89711184326466e-07 2165 1564.54545454545 1254 1.12402711741331e-08 273 2.28239030063925 2.34027243924869 1 15.9915690352822 2163 334 1075 273 1924 1250 1812 3595 1254 1085 2445 891 M12531 GO_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 52/57 Gene Ontology BP GO:0034333 4.13201095635836e-08 1.97691467186943e-07 1300 1285.72727272727 1255 3.75637366724112e-09 277 2.32798746416127 3.03252128272127 1 16.730312695142 1296 353 1255 990 765 1702 2699 2335 277 1495 976 892 M12542 GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of glial cell proliferation. 26/29 Gene Ontology BP GO:0060251 1.91998483774771e-07 3.87324228472971e-07 1255 1371 1255 1.74544091391702e-08 322 2.29934939195967 -1.97153861071916 -1 15.7982889829798 1255 693 1897 660 2268 1718 2551 1073 322 1394 1250 893 M10409 GO_SINGLE_ORGANISM_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism. 107/146 Gene Ontology BP GO:0044801 6.27426926187168e-08 2.12948256567067e-07 950 1851.09090909091 1256 5.70388130982738e-09 214 1.90816227382732 -1.63955702220631 -1 13.6263130340435 950 3027 3120 2813 1256 214 477 2602 1217 3993 693 894 M14188 GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 130/153 Gene Ontology BP GO:0007179 6.55420208147053e-08 2.17413460714792e-07 550 1355.18181818182 1256 5.95836570612017e-09 335 2.18520604164929 2.70462550760951 1 15.5998672326219 549 2633 1256 1751 1297 381 783 1173 1803 2946 335 895 M10906 GO_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_SECRETION.html The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. 37/51 Gene Ontology BP GO:0030073 2.50757578745965e-08 1.97691467186943e-07 3500 1913.18181818182 1257 2.27961437821926e-09 266 2.30800041177622 -2.18978919253107 -1 16.5857027559892 3496 510 1116 780 266 3693 4639 2301 1257 953 2034 896 M11561 GO_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the meiotic cell cycle. 44/61 Gene Ontology BP GO:0051445 4.30838148146259e-08 1.97691467186943e-07 1340 1327 1259 3.91671051439637e-09 454 1.97446067018425 1.99406986594324 1 14.172482396756 1340 454 1831 1017 821 1192 868 2529 1635 1651 1259 897 M10300 GO_REGULATION_OF_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MATURATION.html Any process that modulates the frequency, rate or extent of cell maturation. 22/24 Gene Ontology BP GO:1903429 2.53017163091814e-07 4.64047638890899e-07 690 1550.81818181818 1260 2.30015629264333e-08 92 2.02362143353477 2.45175902079196 1 13.7188507138871 687 2428 2293 1260 2497 520 505 774 3829 2174 92 898 M10616 GO_RESPONSE_TO_PROSTAGLANDIN_E http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN_E.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 38/86 Gene Ontology BP GO:0034695 4.64494343823177e-07 7.46560339139635e-07 1180 1316.63636363636 1260 4.22267674448781e-08 493 2.38389577495437 2.94758729172617 1 15.6501299727139 1176 546 1385 1413 2859 1260 657 493 2145 1242 1307 899 M11573 GO_OVULATION_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE.html The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 107/155 Gene Ontology BP GO:0042698 4.80979546016972e-08 1.98933140232619e-07 2835 1839.72727272727 1260 4.37254142302259e-09 85 2.72228640174776 3.05544865339908 1 19.5751478396635 2833 85 558 1153 979 2136 1709 3755 1260 1191 4578 900 M11944 GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_CARBOXYLATION.html The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. 9/13 Gene Ontology BP GO:0017187 3.5939294046395e-08 1.97691467186943e-07 2705 2098.09090909091 1261 3.59392946276298e-09 155 3.513616974931 -4.51544072770946 -1 25.3085566556395 2705 1068 4334 939 724 3363 3839 680 155 1261 4011 901 M13040 GO_PROTEIN_CARBOXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CARBOXYLATION.html The addition of a carboxy group to a protein amino acid. 9/13 Gene Ontology BP GO:0018214 3.5939294046395e-08 1.97691467186943e-07 2710 2110.72727272727 1264 3.59392946276298e-09 156 3.513616974931 -4.51544072770946 -1 25.3085566556395 2706 1069 4403 940 725 3364 3840 739 156 1264 4012 902 M14093 GO_VENTRICULAR_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_DEVELOPMENT.html The progression of the ventricular septum over time from its formation to the mature structure. 67/78 Gene Ontology BP GO:0003281 6.29135538997818e-08 2.12948256567067e-07 1705 1329.72727272727 1265 5.71941415444774e-09 245 2.19926146119314 2.52597649300399 1 15.7223251756935 1705 245 1339 298 1265 1253 2211 2749 1061 1051 1450 903 M15416 GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AROMATIC_AMINO_ACID_FAMILY_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). 9/21 Gene Ontology BP GO:0009074 4.00835389558059e-08 1.97691467186943e-07 1455 1371.90909090909 1266 4.00835396788164e-09 33 2.96943825320427 -3.56737603669884 -1 21.3713251759229 1454 1080 4555 983 848 1543 1710 262 33 1266 1357 904 M12324 GO_ANATOMICAL_STRUCTURE_REGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_REGRESSION.html The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. 15/20 Gene Ontology BP GO:0060033 6.08520332841739e-07 9.26131069474047e-07 1270 1859.27272727273 1267 5.53200455598746e-08 498 3.06253728787723 3.3078820990671 1 19.8281759781355 1266 3210 2280 1267 3016 1088 555 3671 910 2691 498 905 M15365 GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_PROCESS_INVOLVED_IN_MORPHOGENESIS.html Any apoptotic process that contributes to the shaping of an anatomical structure. 23/28 Gene Ontology BP GO:0060561 8.48505102424227e-07 1.2230775221747e-06 1270 1512.72727272727 1267 7.71368572435785e-08 317 2.21373506208855 2.34924005243273 1 14.0127585604006 1267 815 2217 317 3194 1129 1205 1604 329 3104 1459 906 M14836 GO_RESPONSE_TO_VITAMIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. 130/167 Gene Ontology BP GO:0033273 2.68201497412762e-11 6.74563009438694e-10 1395 1102 1268 2.43819543105484e-12 2 2.89699776349797 3.04993304577905 1 28.5602493900871 1391 2 135 969 1341 1094 1540 2180 1268 371 1831 907 M14491 GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUSION_OF_SPERM_TO_EGG_PLASMA_MEMBRANE.html The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. 4/15 Gene Ontology BP GO:0007342 6.93107750270905e-08 2.20943360292963e-07 1605 1364.36363636364 1269 6.93107771888831e-09 9 4.24250862759234 -3.62420648168675 -1 30.3611027723234 1602 1126 4497 148 1452 1587 762 339 9 2217 1269 908 M10509 GO_RESPONSE_TO_ESTRADIOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTRADIOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 171/226 Gene Ontology BP GO:0032355 3.24444672804144e-08 1.97691467186943e-07 1270 1162.18181818182 1270 2.94949706898988e-09 261 2.48257741559794 2.63915326459088 1 17.8487989551578 1270 1521 261 593 493 1154 1892 2016 1406 462 1716 909 M13964 GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. 18/36 Gene Ontology BP GO:0042430 6.30725919556105e-08 2.13127647327128e-07 2030 1193.81818181818 1270 5.73387216035103e-09 234 3.13399454453001 -3.70887448654193 -1 22.4514811184084 2029 884 1179 1329 1270 1497 1620 234 346 1168 1576 910 M16166 GO_EPOXYGENASE_P450_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPOXYGENASE_P450_PATHWAY.html The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. 9/57 Gene Ontology BP GO:0019373 1.79097186066692e-08 1.97691467186943e-07 1270 1694.72727272727 1270 1.79097187510103e-09 117 3.2284673996294 -2.64516103655765 -1 23.2454479020615 3101 1065 4600 160 117 1980 1717 2935 430 1267 1270 911 M11889 GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. 468/638 Gene Ontology BP GO:0060627 3.14862903034935e-08 1.97691467186943e-07 1325 1170.90909090909 1273 2.86239006855671e-09 422 1.98934769329486 -1.88603028023907 -1 14.2801927016433 1325 1273 762 697 459 918 1932 1483 1861 422 1748 912 M13075 GO_SOMITOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMITOGENESIS.html The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. 70/100 Gene Ontology BP GO:0001756 6.36661400520601e-08 2.14510173542531e-07 1355 1137.45454545455 1274 5.7878310813186e-09 234 2.27620348842668 2.82254742275306 1 16.2685370595627 1355 234 1249 1401 1274 843 607 1792 1596 1425 736 913 M15511 GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT.html Any process that modulates the frequency, rate or extent of the movement of a cellular component. 865/1139 Gene Ontology BP GO:0051270 2.59229725455926e-20 2.94194125011323e-18 1150 1641.63636363636 1274 2.59229725455927e-21 21 2.36455749499135 2.64361425872168 1 44.6252808653503 1146 1199 4560 1274 586 1819 2094 1156 2018 21 2185 914 M10841 GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 517/769 Gene Ontology BP GO:0071407 3.25227177551226e-08 1.97691467186943e-07 1275 1488.18181818182 1275 3.25227182310998e-09 335 2.26112161221818 2.37010031063975 1 16.24652616201 967 1275 4265 1716 610 335 1274 1764 2206 479 1479 915 M12018 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. 402/532 Gene Ontology BP GO:0000226 1.02917738740257e-07 2.6225423787427e-07 885 1479.81818181818 1276 9.35615850498462e-09 794 1.83062874526355 2.00469191878851 1 12.8893490900921 882 1317 2248 3018 1760 1126 1245 794 1179 1276 1433 916 M10713 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_PAIN.html The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. 25/37 Gene Ontology BP GO:0050965 1.6782911854504e-08 1.97691467186943e-07 1740 1079.63636363636 1277 1.52571927113946e-09 58 2.69337030499336 3.08919347213198 1 19.3739236369804 1736 749 1277 286 58 1469 921 1876 142 1910 1452 917 M13312 GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. 165/217 Gene Ontology BP GO:0010771 3.95253590695188e-08 1.97691467186943e-07 1625 1104.18181818182 1277 3.59321452542131e-09 175 2.27542236769202 2.62074668570434 1 16.3499947145044 1624 1524 427 175 723 943 1509 2167 1289 488 1277 918 M12295 GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. 98/122 Gene Ontology BP GO:0032091 5.50896418571932e-08 2.05617623085131e-07 1280 1774.36363636364 1278 5.00814938515265e-09 115 1.68213444981141 2.128008300224 1 12.0264558525545 1278 115 2658 3058 1123 975 1193 2173 2725 3162 1058 919 M15576 GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_TEMPERATURE_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION.html The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. 25/37 Gene Ontology BP GO:0050961 1.6782911854504e-08 1.97691467186943e-07 1740 1085.81818181818 1278 1.52571927113946e-09 59 2.69337030499336 3.08919347213198 1 19.3739236369804 1737 750 1278 287 59 1470 922 1929 143 1916 1453 920 M16700 GO_RESPONSE_TO_MONOAMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MONOAMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. 53/70 Gene Ontology BP GO:0071867 6.40450622397429e-08 2.15319129047344e-07 505 1334.09090909091 1278 5.82227855492582e-09 303 1.89848693277675 2.17635012987339 1 13.546795100272 502 1748 2266 2024 1278 303 377 732 3550 1384 511 921 M10968 GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 84/99 Gene Ontology BP GO:0061180 6.23639913106853e-08 2.12948256567067e-07 4480 2072.54545454545 1279 5.66945391623039e-09 265 2.7638986305178 -2.71876457942703 -1 19.7879028684411 4480 2240 680 265 1250 3851 3950 1279 852 1087 2864 922 M12042 GO_NEGATIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COAGULATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. 48/67 Gene Ontology BP GO:0050819 6.41855617273175e-14 2.6665662385465e-12 1520 1302.18181818182 1280 5.83505106611994e-15 49 3.73190963379631 3.63000002867894 1 46.5024712216086 1520 355 76 1280 49 1975 2446 1195 3041 149 2238 923 M14086 GO_DETECTION_OF_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_BIOTIC_STIMULUS.html The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. 38/76 Gene Ontology BP GO:0009595 1.10536612022991e-06 1.53164638398743e-06 190 1854.18181818182 1280 1.00487879600865e-07 186 1.29727805181603 -1.34747523824995 -1 8.02804855325311 186 556 3103 3480 3324 483 840 932 4449 1763 1280 924 M10491 GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. 297/367 Gene Ontology BP GO:0032886 8.65468791099561e-08 2.45384890956523e-07 1270 1463.18181818182 1281 7.8678984104242e-09 826 1.7357890492195 1.96401224846405 1 12.2698206034454 1036 1368 2761 2259 1568 826 1281 1266 1267 937 1526 925 M13602 GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_METABOLIC_PROCESS.html The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required. 93/145 Gene Ontology BP GO:0044236 1.57855049009721e-16 1.08014638682681e-14 230 1252.27272727273 1281 1.43504590008837e-17 41 3.42447354359854 3.36072575218943 1 51.5043523854454 227 2215 41 1281 3050 1189 1032 1443 1679 290 1328 926 M12094 GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_SEQUESTERED_CALCIUM_ION_INTO_CYTOSOL.html Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria. 37/59 Gene Ontology BP GO:0051281 6.44102339112899e-08 2.15972315171505e-07 2620 1839.81818181818 1282 5.85547598155025e-09 241 2.37948439255352 2.27828716229984 1 17.0042644420418 2620 496 1105 528 1282 2938 3509 4271 241 954 2294 927 M13762 GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. 25/45 Gene Ontology BP GO:0031664 1.32191522478444e-06 1.78493080119616e-06 335 1395.54545454545 1282 1.20174183553186e-07 333 2.37658069643936 -2.52908122487013 -1 14.6308077014985 333 775 1282 1907 3411 683 2236 1198 1505 1590 431 928 M15357 GO_GOLGI_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_VESICLE_TRANSPORT.html The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. 387/431 Gene Ontology BP GO:0048193 2.33483741057185e-08 1.97691467186943e-07 1190 1847.27272727273 1282 2.12257948668295e-09 200 1.64901854888834 -1.39131670485686 -1 11.8178497850174 1189 1332 3939 2574 200 608 999 2933 843 4421 1282 929 M11212 GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. 45/66 Gene Ontology BP GO:0045806 1.73271918950971e-07 3.60278591263368e-07 1285 1421.90909090909 1284 1.57519938725329e-08 466 1.71744775166473 -1.56502884426808 -1 11.8298255124213 1284 466 2950 836 2193 878 1520 764 1296 2868 586 930 M12990 GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 231/352 Gene Ontology BP GO:0070372 5.48220265879593e-08 2.05617623085131e-07 1580 1477.81818181818 1284 4.98382072309772e-09 572 2.20423485601789 2.15560433148955 1 15.7943269831929 1578 1440 599 1249 1115 604 1284 2432 3025 572 2358 931 M11002 GO_SINGLE_ORGANISM_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELL_ADHESION.html The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix. 478/734 Gene Ontology BP GO:0098602 1.20657587622839e-23 2.44095545743075e-21 1460 1068 1285 1.09688716020763e-24 9 2.51264207502138 2.8500603201511 1 55.7821185047063 1456 1260 11 9 472 1285 2128 1286 1952 44 1845 932 M11292 GO_HORMONE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_TRANSPORT.html The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 72/118 Gene Ontology BP GO:0009914 6.45178418414768e-08 2.15972315171505e-07 4055 2007.90909090909 1285 5.86525852123145e-09 113 2.50194477837377 -2.6253649824117 -1 17.8852110775542 4054 204 626 113 1285 3917 4548 2532 767 722 3319 933 M14216 GO_DETECTION_OF_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_VISIBLE_LIGHT.html The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 39/83 Gene Ontology BP GO:0009584 2.43534190990941e-08 1.97691467186943e-07 1530 1408.18181818182 1285 2.21394721533454e-09 242 2.50571122296708 2.64838692696269 1 18.0161762357881 1530 503 847 1705 242 1663 3285 1285 2525 948 957 934 M11955 GO_REPLACEMENT_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPLACEMENT_OSSIFICATION.html Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. 42/52 Gene Ontology BP GO:0036075 4.2076941814341e-07 6.88534070403538e-07 485 1371.72727272727 1286 3.82517726017543e-08 481 3.0804345744594 3.43061203511463 1 20.3727313179367 481 1767 491 1040 2806 991 1327 2522 951 1427 1286 935 M14065 GO_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_DEVELOPMENT.html The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 266/418 Gene Ontology BP GO:0008544 4.17713649971764e-21 5.25303138734761e-19 1575 1279.36363636364 1287 3.79739681792513e-22 20 2.86751181577978 3.18631282344953 1 56.4569144050181 1573 1389 20 1287 484 1429 2855 915 3203 76 842 936 M14377 GO_TUBE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUBE_FORMATION.html Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. 156/190 Gene Ontology BP GO:0035148 2.13926856036487e-08 1.97691467186943e-07 955 1282 1287 1.94478961924274e-09 158 1.94508727839787 2.05813458329712 1 13.9599605942857 951 1529 1287 1350 158 412 1546 3175 1087 1000 1607 937 M15454 GO_ENDOCHONDRAL_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCHONDRAL_OSSIFICATION.html Replacement ossification wherein bone tissue replaces cartilage. 42/52 Gene Ontology BP GO:0001958 4.2076941814341e-07 6.88534070403538e-07 485 1374 1287 3.82517726017543e-08 482 3.0804345744594 3.43061203511463 1 20.3727313179367 482 1768 492 1041 2807 992 1328 2536 952 1429 1287 938 M12615 GO_CHLORIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHLORIDE_TRANSPORT.html The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 60/116 Gene Ontology BP GO:0006821 6.47451996304431e-08 2.16187652577705e-07 2165 1224.18181818182 1289 5.88592741235192e-09 260 2.41441826762819 -2.43842080146479 -1 17.2544414578496 2161 260 546 1827 1289 1401 1869 1816 1065 366 866 939 M12302 GO_LIPOPROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_TRANSPORT.html The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/19 Gene Ontology BP GO:0042953 1.19469829669213e-07 2.84781310169492e-07 940 1678.18181818182 1290 1.08608941960872e-08 813 2.29260460149658 2.7144632358972 1 16.0820842001277 936 2908 2220 1246 1892 1049 813 1290 1727 3359 1020 940 M14434 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. 26/34 Gene Ontology BP GO:0060045 7.36972410000783e-08 2.26644588482065e-07 2010 1222.36363636364 1290 6.6997494062585e-09 174 3.01902430502271 3.19164683293394 1 21.5366893057151 2006 611 499 239 1419 1290 1353 2022 174 921 2912 941 M15100 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 34/49 Gene Ontology BP GO:0032228 6.47680179869593e-08 2.16187652577705e-07 2750 1557.63636363636 1290 5.88800180852093e-09 161 2.31796010643379 -2.43085163668263 -1 16.5605927936332 2749 529 1007 161 1290 2801 2586 2104 412 600 2895 942 M11722 GO_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. 376/485 Gene Ontology BP GO:0016055 6.49257653269263e-08 2.16403714947126e-07 1335 1456 1292 5.90234247663606e-09 748 1.94723014321363 2.2688413800359 1 13.8929239661738 1157 1333 2273 1018 1292 1118 1666 1333 1035 3043 748 943 M13536 GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. 42/46 Gene Ontology BP GO:0070830 1.76632749667982e-07 3.65481746361674e-07 1295 1162.09090909091 1292 1.60575239863096e-08 136 2.2991976472132 -2.77469365565532 -1 15.8597916173838 1293 438 1292 431 2204 1601 3523 136 160 1428 277 944 M11775 GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_FOLLICLE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of hair follicle development. 14/18 Gene Ontology BP GO:0051797 3.76290652987485e-07 6.33917598968416e-07 2950 1727.36363636364 1293 3.42082470317006e-08 198 3.69363559203766 4.47201345661452 1 24.5937833590393 2946 969 717 198 2727 3359 3506 1293 248 1142 1896 945 M16315 GO_CENTROMERE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROMERE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. 37/52 Gene Ontology BP GO:0034508 1.71289929673513e-06 2.23754082754311e-06 65 1334.72727272727 1293 1.55718239125805e-07 49 1.94712669874315 1.87747275493072 1 11.7602960289441 61 1800 2017 2258 3532 337 49 747 1200 1388 1293 946 M16002 GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rho protein signal transduction. 131/144 Gene Ontology BP GO:0035023 2.86158204316382e-08 1.97691467186943e-07 1575 1126.81818181818 1294 2.60143825489543e-09 323 2.42711526662882 2.71074327257097 1 17.4475202756809 1145 1571 347 454 375 1294 1873 1518 1573 323 1922 947 M11353 GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cell junction assembly. 116/135 Gene Ontology BP GO:1901888 3.2628665115084e-08 1.97691467186943e-07 1205 1317.45454545455 1295 2.96624232718243e-09 499 2.18699752697654 2.51255345184255 1 15.710224998134 1205 1618 1012 1076 499 635 1295 1559 2280 1716 1597 948 M12833 GO_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_TASTE.html The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. 28/88 Gene Ontology BP GO:0050909 1.98769008441975e-08 1.97691467186943e-07 1295 1542.09090909091 1295 1.80699100216222e-09 121 2.70873901860525 -2.60061624996694 -1 19.4851190597699 1295 2766 1144 2726 121 945 808 2279 2281 1675 923 949 M12767 GO_POSITIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIVISION.html Any process that activates or increases the frequency, rate or extent of cell division. 126/192 Gene Ontology BP GO:0051781 6.75820743676538e-08 2.19748002818095e-07 1420 1377.72727272727 1297 6.14382513124693e-09 22 2.26289628904673 2.42388125300455 1 16.1471794083101 1420 22 1190 773 1336 1297 1078 3699 1356 1056 1928 950 M13317 GO_GLYCOPROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 22/29 Gene Ontology BP GO:0006516 4.40628717515125e-08 1.97691467186943e-07 4190 1778.72727272727 1299 4.00571569400266e-09 107 2.91367299210771 -1.9118379840539 -1 20.9678534253787 4186 765 1068 1299 847 2708 1819 1186 107 1449 4132 951 M13725 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_E_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. 36/61 Gene Ontology BP GO:0071380 9.49418322218941e-07 1.3480755121406e-06 1455 1471.54545454545 1299 8.63107938131141e-08 570 2.27683291936935 2.80672863353593 1 14.31154324558 1452 570 1568 1241 3244 1299 653 784 2341 1269 1766 952 M15850 GO_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_DEATH.html The process of cell death in a neuron. 58/89 Gene Ontology BP GO:0070997 2.4993741113119e-08 1.97691467186943e-07 2050 1157 1299 2.27215830882433e-09 260 2.23766394907869 2.68485470772163 1 16.076805726304 2050 302 1299 624 260 1777 1352 654 1487 1221 1701 953 M16155 GO_RESPONSE_TO_ALCOHOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALCOHOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. 421/571 Gene Ontology BP GO:0097305 6.66320925011668e-19 6.3273291103659e-17 1375 1062 1299 6.0574629546515e-20 27 2.55605772491047 2.68400916134182 1 44.5724986595933 1373 1299 27 68 993 774 1723 1893 1611 85 1836 954 M15789 GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cell differentiation. 910/1237 Gene Ontology BP GO:0045597 5.8788833474451e-14 2.55649011361328e-12 1300 1413.54545454545 1300 5.87888334744524e-15 54 2.33421902747821 2.60430887730115 1 29.0899323501544 1300 1187 4572 377 759 819 1855 1369 1570 54 1687 955 M16008 GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARF_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of ARF protein signal transduction. 14/16 Gene Ontology BP GO:0032012 1.79653173921795e-06 2.32848528762706e-06 1795 1841.90909090909 1302 1.6332120057064e-07 10 3.01121474467764 -2.20440577419375 -1 18.1927741654254 1792 3798 2598 763 3559 1197 1302 1045 10 3369 828 956 M16246 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport. 28/42 Gene Ontology BP GO:1901381 1.12892048443943e-07 2.74875301627245e-07 3980 1959.09090909091 1302 1.02629140215409e-08 368 2.65147148207168 2.91936687088189 1 18.6611532902306 3977 617 719 938 1845 3902 4236 1302 838 368 2808 957 M11251 GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic hydroxy compound. 420/648 Gene Ontology BP GO:1901615 1.95557594000773e-08 1.97691467186943e-07 1155 1095.81818181818 1303 1.77779632490073e-09 114 2.20209693915768 -2.17493974539613 -1 15.8194719763624 1153 1303 338 1821 114 592 1621 1390 1661 580 1481 958 M16781 GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANATOMICAL_STRUCTURE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. 313/463 Gene Ontology BP GO:0060249 9.59461844904071e-08 2.53801930889064e-07 1290 1669.45454545455 1303 8.72238078861843e-09 581 2.08143625566559 2.21428706089234 1 14.7027252475047 1289 2988 797 2124 1695 581 1229 1303 3303 1779 1276 959 M11019 GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that modulates the frequency, rate or extent of protein oligomerization. 33/43 Gene Ontology BP GO:0032459 5.28799014027368e-08 2.04581932255101e-07 1395 1261.45454545455 1305 4.80726387943411e-09 188 2.78427955528466 -2.58159338562472 -1 19.9869578081104 1393 624 1043 1155 1075 1305 2170 1730 1470 1723 188 960 M12586 GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRAL_NERVOUS_SYSTEM_MYELINATION.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 11/20 Gene Ontology BP GO:0022010 1.44647987613558e-08 1.97691467186943e-07 2200 1644.90909090909 1305 1.31498171422369e-09 5 4.48654279254645 5.41037133122619 1 32.3478509235035 2199 1041 855 517 3467 2598 2451 5 17 1305 3639 961 M12986 GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM.html The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 11/20 Gene Ontology BP GO:0032291 6.19813293454809e-09 1.02999687658758e-07 2200 1645.63636363636 1306 5.63466632000935e-10 3 4.48654279254645 5.41037133122619 1 33.7188781476435 2200 1042 856 518 3468 2599 2452 3 18 1306 3640 962 M13852 GO_DICARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_TRANSPORT.html The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 68/107 Gene Ontology BP GO:0006835 1.80417131987041e-07 3.71141007772568e-07 3150 1385.36363636364 1307 1.6401558798423e-08 71 2.62549501455079 -2.58535789023254 -1 18.1077222090513 3148 216 696 71 2217 2297 1998 1307 274 642 2373 963 M16208 GO_RESPONSE_TO_OSMOTIC_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OSMOTIC_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. 89/135 Gene Ontology BP GO:0006970 5.58699834671286e-08 2.05622555659363e-07 2445 1495.90909090909 1309 5.07908953508834e-09 129 2.52605359334401 2.90461209457944 1 18.1167858178111 2442 129 627 506 1140 2934 2581 1309 1615 689 2483 964 M16600 GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 78/125 Gene Ontology BP GO:0043266 3.89447956297479e-08 1.97691467186943e-07 3070 1678.54545454545 1309 3.54043602901415e-09 152 2.61453065875595 2.75700742267501 1 18.8035045363755 3066 163 534 152 705 3461 3713 3146 1309 244 1971 965 M12081 GO_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSPORT.html The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 374/632 Gene Ontology BP GO:0006820 1.8201505846116e-15 1.02038080363829e-13 2505 1491.09090909091 1311 1.65468234964691e-16 50 2.44478930604464 -2.31162519100701 -1 34.1641996551879 2502 1311 53 1092 634 1320 2072 3506 1303 50 2559 966 M14639 GO_HEART_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_DEVELOPMENT.html The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. 39/47 Gene Ontology BP GO:0003170 2.55499950734277e-06 3.19409261355881e-06 1315 1539.63636363636 1311 2.3227295223914e-07 585 2.72071989109571 3.30510887311414 1 16.023712851395 1311 2318 981 782 3692 950 1657 808 2225 1627 585 967 M16623 GO_COPULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPULATION.html The act of sexual union between male and female, involving the transfer of sperm. 11/20 Gene Ontology BP GO:0007620 1.03136232573946e-07 2.62523462891997e-07 820 1421.63636363636 1311 9.37602158263489e-09 288 3.38326308259524 3.8127323736687 1 23.9156518443466 819 1064 1141 3038 1762 1323 1921 313 2658 1311 288 968 M11688 GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of muscle tissue development. 119/167 Gene Ontology BP GO:1901861 2.03357051502993e-07 4.01451150039637e-07 1545 1185.27272727273 1312 1.84870063909372e-08 27 2.26585781317752 2.75815515483013 1 15.5284834728581 1542 27 949 308 2316 701 982 2035 1510 1312 1356 969 M14239 GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. 155/300 Gene Ontology BP GO:0051480 2.01241802725985e-12 6.12011835349025e-11 1315 1225.72727272727 1313 1.82947093387427e-13 67 2.83742419729806 3.14433361579319 1 31.1622695550237 1313 1531 108 67 1540 923 2050 2563 2333 219 836 970 M16709 GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. 328/469 Gene Ontology BP GO:0071214 3.33432898853863e-08 1.97691467186943e-07 1265 1311.36363636364 1313 3.03120821733987e-09 532 2.08297980221091 2.4156328487216 1 14.9576379453065 1261 1359 1005 1785 532 1150 1527 669 2432 1392 1313 971 M11112 GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE.html A process that modulates the size of a cellular component. 383/480 Gene Ontology BP GO:0032535 2.03501031646815e-08 1.97691467186943e-07 2605 1706 1314 1.85000939572008e-09 130 2.24513213113888 2.53708970560799 1 16.1308393743128 2601 1314 317 416 130 3065 3746 2474 1232 354 3117 972 M14953 GO_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 32/46 Gene Ontology BP GO:0010226 4.61597096896294e-06 5.50375410790689e-06 2685 1738.09090909091 1314 4.19634604916076e-07 164 3.31130449145089 3.83387595726006 1 18.6820200814027 2684 1834 1132 1314 3876 2387 1215 360 164 2892 1261 973 M15312 GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 30/34 Gene Ontology BP GO:0090181 5.72134124287633e-07 8.82087501759561e-07 750 1791.63636363636 1315 5.20122066434037e-08 323 1.58374989536431 -1.4536412714008 -1 10.2354320202593 746 2754 3127 3119 2980 752 323 328 1315 3542 722 974 M12840 GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_NEURON_SYNAPTIC_TRANSMISSION.html The process of communication from a neuron to another neuron across a synapse. 50/105 Gene Ontology BP GO:0007270 3.06407332357741e-08 1.97691467186943e-07 1930 1436 1316 2.78552124204784e-09 323 2.36653497247789 3.12538009039319 1 17.0092108900719 1930 323 535 1316 430 2026 3003 3321 1891 431 590 975 M14229 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus. 23/32 Gene Ontology BP GO:1902547 1.43389126466693e-07 3.17558117777021e-07 1320 1129.09090909091 1316 1.30353759829408e-08 71 2.89128377042799 2.96088785188024 1 20.1635822185547 851 1908 1316 1317 2046 936 1758 173 106 1938 71 976 M14273 GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 234/288 Gene Ontology BP GO:0010810 4.52132351806989e-08 1.97760774550163e-07 1320 1316.36363636364 1316 4.11029419180886e-09 271 2.33801178566957 2.52740548553971 1 16.8024563596813 1316 1418 271 1308 902 960 1619 2508 2140 465 1573 977 M12330 GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 54/78 Gene Ontology BP GO:0045661 6.64181798252038e-08 2.18097241162084e-07 4505 2247.54545454545 1318 6.038016530034e-09 330 2.75546531833112 -2.14378005100179 -1 19.6963239422039 4503 330 682 748 1318 4650 3919 3218 841 813 3701 978 M13399 GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin. 17/30 Gene Ontology BP GO:0033630 1.86061562586971e-07 3.79379689183689e-07 1145 1599.27272727273 1318 1.69146889384399e-08 549 1.87739385726205 -2.21037915575285 -1 12.8966135505181 1141 2477 2166 1610 2240 1219 736 549 3109 1318 1027 979 M15731 GO_PHOSPHOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. 27/34 Gene Ontology BP GO:0009395 4.71898960463058e-08 1.98252330758246e-07 1925 1701 1318 4.28999064168425e-09 656 2.3311518026565 -2.10214247808624 -1 16.7501118089788 1925 656 1382 1318 953 2558 3571 3201 1140 1236 771 980 M16696 GO_CENTROSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_LOCALIZATION.html Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. 31/32 Gene Ontology BP GO:0051642 1.15283889907349e-06 1.58796903415896e-06 1320 1598.90909090909 1318 1.04803591198355e-07 330 1.7693701488123 2.21797408760514 1 10.9607422069264 1318 641 2863 1791 3344 1206 675 330 2627 2094 699 981 M14842 GO_THALAMUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THALAMUS_DEVELOPMENT.html The process in which the thalamus changes over time, from its initial formation to its mature state. 17/31 Gene Ontology BP GO:0021794 1.06175282583905e-07 2.65752334514745e-07 2650 1661.54545454545 1319 9.652298882553e-09 72 3.04881971648131 3.03407804981354 1 21.5228859617063 2648 883 1245 255 1789 2317 2424 4311 72 1319 1014 982 M15094 GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. 17/26 Gene Ontology BP GO:0043567 1.18926493625875e-06 1.62946105665842e-06 975 1499.63636363636 1321 1.08115052649645e-07 297 3.32395507679892 3.96691730196281 1 20.6501350766393 974 2481 1136 1686 3361 1984 1173 456 297 1321 1627 983 M15499 GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING_SPREADING_OF_EPIDERMAL_CELLS.html The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. 28/31 Gene Ontology BP GO:0035313 5.9729039981092e-08 2.09276523367486e-07 315 1442.63636363636 1321 5.42991287297357e-09 260 4.08942694670676 3.89549132340782 1 29.3654902025639 311 2349 260 1338 4055 1177 1321 2468 534 730 1326 984 M16275 GO_REGULATION_OF_CELL_PROJECTION_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_SIZE.html A process that modulates the size of a cell projection. 17/27 Gene Ontology BP GO:0032536 8.01737531204218e-08 2.35520479581606e-07 2800 1406.90909090909 1323 7.28852327656031e-09 47 3.70398002931814 -3.9312915340407 -1 26.3818985395927 2800 859 765 410 1496 3792 2139 337 47 1323 1508 985 M11335 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_VIA_MHC_CLASS_IB.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. 27/45 Gene Ontology BP GO:0002475 7.53532039887681e-07 1.1064009408638e-06 330 1750.81818181818 1324 6.85029361803184e-08 74 1.5268107790085 -1.24022723076796 -1 9.70123756087402 74 673 2570 3339 3138 326 327 1324 4159 2208 1121 986 M12989 GO_ORGANELLE_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_MEMBRANE_FUSION.html The joining of two lipid bilayers to form a single organelle membrane. 82/104 Gene Ontology BP GO:0090174 6.13088277503689e-08 2.11467735746825e-07 1325 1836.45454545455 1324 5.57352995080927e-09 329 1.82295147534138 -1.53268153731788 -1 13.0187277300226 1324 2654 3051 2335 1241 329 514 3529 914 3770 540 987 M12361 GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling. 34/51 Gene Ontology BP GO:0050850 1.12362866410108e-08 1.77740684677253e-07 3565 2031 1327 1.02148060894536e-09 6 2.3067087811091 2.48760720164628 1 16.6913738928632 3563 565 1350 638 6 4611 3873 1327 869 900 4639 988 M12385 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE.html A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 14/15 Gene Ontology BP GO:0033540 2.58332502790529e-08 1.97691467186943e-07 1580 1486.90909090909 1329 2.34847732567244e-09 283 1.34842782609074 -0.987369920737535 -1 9.64302153639694 1579 938 2908 2324 283 1402 1072 800 361 3360 1329 989 M12416 GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. 12/27 Gene Ontology BP GO:1901533 4.05371476398683e-07 6.71721324673459e-07 1725 1417.81818181818 1329 3.68519591902139e-08 137 2.18641490664757 -3.12826398187451 -1 14.452561867625 1725 1022 1924 800 2770 2229 1329 192 137 3068 400 990 M15257 GO_REGULATION_OF_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ASSEMBLY.html Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 20/28 Gene Ontology BP GO:0090169 6.69915631916523e-08 2.18361447198576e-07 510 1793.36363636364 1330 6.09014229378121e-09 115 1.07796750995538 -0.940629629323956 -1 7.63594828096305 509 2829 3567 2943 1330 660 267 282 4167 3058 115 991 M11761 GO_AXON_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXON_REGENERATION.html The regrowth of axons following their loss or damage. 26/34 Gene Ontology BP GO:0031103 6.51636258600451e-08 2.16885801950493e-07 2450 1680.72727272727 1331 5.9239661627437e-09 718 2.43091159849204 2.71221794996186 1 17.3694087364632 2448 718 1331 1354 1294 1591 974 4588 938 919 2333 992 M16840 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation. 53/108 Gene Ontology BP GO:0046635 2.65773343813598e-07 4.81934282449209e-07 250 1614 1331 2.4161215992785e-08 250 1.62787328948215 -1.59644816666948 -1 10.9849584280526 250 359 2530 2856 2524 426 660 1331 3935 1847 1036 993 M12900 GO_PROTEIN_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMANNOSYLATION.html The removal of one or more mannose residues from a mannosylated protein. 13/14 Gene Ontology BP GO:0036507 1.17062376864232e-07 2.82053557561036e-07 750 1450.72727272727 1332 1.06420348266493e-08 177 1.61058325216552 -1.59712617651939 -1 11.2714845282076 748 2026 3118 1749 1871 880 598 1332 177 2793 666 994 M13820 GO_RESPONSE_TO_CAFFEINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAFFEINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. 28/34 Gene Ontology BP GO:0031000 6.70148606489505e-08 2.18361447198576e-07 1145 1752.90909090909 1332 6.09226024457365e-09 677 1.97722391378119 2.48121509066119 1 14.1003167716019 1142 2780 2434 2637 1332 1124 833 677 2415 3040 868 995 M14567 GO_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 102/134 Gene Ontology BP GO:0072091 7.00443460310675e-08 2.21862724358446e-07 790 1448.18181818182 1332 6.36766802374213e-09 488 2.29425611047174 2.96929515889926 1 16.3622198474236 790 2647 1332 1664 1374 941 1138 659 2542 2355 488 996 M12778 GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT.html The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. 448/630 Gene Ontology BP GO:0061458 3.48577219233598e-08 1.97691467186943e-07 2120 1855.72727272727 1334 3.16888386142366e-09 235 2.31936609616509 2.30086674219473 1 16.6679355383045 2118 2982 458 235 582 1166 1334 4566 1762 1069 4141 997 M13538 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. 35/47 Gene Ontology BP GO:0055025 1.37690623163252e-07 3.09474584282461e-07 1470 1327 1334 1.25173301618952e-08 293 2.87398906882847 3.08707981163275 1 20.077027384263 1468 541 734 293 2013 974 1273 2455 1334 1414 2098 998 M15585 GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 30/49 Gene Ontology BP GO:0032350 4.67638950528988e-08 1.98236457419581e-07 2460 1560.36363636364 1336 4.25126327699336e-09 678 3.22752466767844 3.06526768042925 1 23.2344624846089 2460 678 724 1336 944 2745 2545 1063 2322 1363 984 999 M11173 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface. 18/22 Gene Ontology BP GO:2000010 6.22032439895007e-07 9.42160463161285e-07 2030 1820.63636363636 1337 5.65484196154349e-08 269 2.8563289841648 -2.90071812286546 -1 18.4625069587999 2026 886 1337 825 3032 3361 3396 269 3215 1166 514 1000 M14457 GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 594/724 Gene Ontology BP GO:0051493 3.62856436376818e-08 1.97691467186943e-07 1340 1540.09090909091 1337 3.62856442301734e-09 358 1.97944559385166 2.27720315758268 1 14.208549221135 1337 1233 4494 908 734 1556 2116 1051 1567 358 1587 1001 M11240 GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALPHA_1_2_DEMANNOSYLATION.html The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. 13/14 Gene Ontology BP GO:0036508 1.17062376864232e-07 2.82053557561036e-07 750 1449.90909090909 1339 1.06420348266493e-08 176 1.61058325216552 -1.59712617651939 -1 11.2714845282076 747 2025 3117 1748 1870 879 597 1339 176 2786 665 1002 M15198 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin polymerization. 76/97 Gene Ontology BP GO:0030838 2.40099038505709e-08 1.97691467186943e-07 1765 1295.09090909091 1341 2.18271855569137e-09 175 2.12250294273618 -1.93629282986589 -1 15.243595015733 1765 175 1302 1000 231 1498 1701 2195 1341 808 2230 1003 M16741 GO_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 330/422 Gene Ontology BP GO:0009100 1.42269270196958e-08 1.97691467186943e-07 2095 1571.09090909091 1341 1.29335701015439e-09 48 2.38713758970514 2.75271435974459 1 17.158274552198 2092 1341 225 380 48 3196 3530 2068 1189 527 2686 1004 M14212 GO_LIPOPROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_LOCALIZATION.html Any process in which a lipoprotein is transported to, or maintained in, a specific location. 14/19 Gene Ontology BP GO:0044872 1.19469829669213e-07 2.84781310169492e-07 940 1684.36363636364 1343 1.08608941960872e-08 814 2.29260460149658 2.7144632358972 1 16.0820842001277 937 2909 2221 1247 1893 1050 814 1343 1728 3365 1021 1005 M14884 GO_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ASSEMBLY.html A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. 179/211 Gene Ontology BP GO:0034329 2.50856986770581e-12 7.53056489963558e-11 1335 1299.27272727273 1343 2.28051806155334e-13 109 2.62277013920722 2.90774250782226 1 28.5413122871643 1334 1475 109 353 1315 1726 2206 2075 1343 220 2136 1006 M10999 GO_PEROXISOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEROXISOME_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. 35/36 Gene Ontology BP GO:0007031 9.46590024762294e-07 1.34488042296762e-06 315 1814.54545454545 1344 8.60536756409199e-08 57 1.27649267003396 -0.887932307456254 -1 7.97541013499946 312 3398 3637 2901 3719 87 57 103 1344 4098 304 1007 M12452 GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT.html The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. 73/109 Gene Ontology BP GO:0035050 4.61835168709625e-08 1.97760774550163e-07 2055 1405.27272727273 1344 4.19850162186093e-09 200 1.97650509773794 2.24536059082146 1 14.1869494775354 2053 200 1344 1552 929 1756 2729 2246 1196 1131 322 1008 M15388 GO_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_SECRETION.html Any process that modulates the frequency, rate, or extent of peptide secretion. 224/327 Gene Ontology BP GO:0002791 5.47198974856914e-08 2.05617623085131e-07 1695 1298.45454545455 1344 4.97453625879292e-09 159 2.38649890860929 2.38202281135266 1 17.1096821404549 1692 1444 548 159 1112 1097 1344 2651 1568 448 2220 1009 M10238 GO_GLUTAMATE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_SECRETION.html The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. 32/54 Gene Ontology BP GO:0014047 7.88043839888394e-08 2.33849999170963e-07 3000 1479.27272727273 1345 7.16403516469330e-09 235 2.85479688243771 -2.55669325192344 -1 20.3171178458678 2997 599 1049 1305 1482 2637 2777 235 272 1345 1574 1010 M13211 GO_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 91/128 Gene Ontology BP GO:0060191 6.8152980746395e-08 2.20228333272585e-07 3250 1684.18181818182 1345 6.1957257143346e-09 114 2.95553853291945 -3.02258455141021 -1 21.1212077687067 3250 114 397 770 1345 4017 4165 611 1808 684 1365 1011 M16302 GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. 126/167 Gene Ontology BP GO:0071260 1.23547310255444e-07 2.89711184326466e-07 940 1595.63636363636 1345 1.12315742903271e-08 570 2.13097116099503 2.69064670834027 1 14.9231475747504 940 2635 1345 2221 1923 890 1145 570 3201 1712 970 1012 M16662 GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH.html Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. 8/12 Gene Ontology BP GO:0042487 2.85204728735818e-07 5.1001445150183e-07 1425 1675.54545454545 1345 2.85204765339606e-08 442 4.14219559596221 4.74750898241512 1 28.0164493491771 1422 2079 4642 1345 2618 1138 1275 442 1102 1524 844 1013 M15892 GO_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. 121/178 Gene Ontology BP GO:0007498 1.78046324543714e-07 3.6715029165863e-07 490 1505.36363636364 1346 1.61860308139118e-08 261 2.17087464165182 2.52065763495414 1 14.9636767790543 487 3018 1346 3167 2212 261 454 1083 2712 1418 401 1014 M10062 GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 35/50 Gene Ontology BP GO:0050856 2.43711676843914e-08 1.97691467186943e-07 3005 1952.45454545455 1347 2.21556072312459e-09 243 2.30691615772501 -2.435988058188 -1 16.5778579818149 3003 534 1211 1347 243 3474 3616 2788 567 667 4027 1015 M12976 GO_REGULATION_OF_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_METAL_ION_TRANSPORT.html Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 307/505 Gene Ontology BP GO:0010959 2.49402443978573e-13 9.28375657465841e-12 3440 1845.54545454545 1347 2.26729494526001e-14 29 2.47260811351614 2.69840344360665 1 29.3267136926809 3440 1347 94 29 674 2946 3646 3082 811 58 4174 1016 M10109 GO_ATP_DEPENDENT_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_DEPENDENT_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. 77/200 Gene Ontology BP GO:0043044 2.79089584313802e-06 3.4620203567372e-06 285 1866.27272727273 1349 2.5371812578583e-07 285 1.83318210408823 1.84240589101592 1 10.6904446037667 285 3358 2924 2548 3723 687 819 1061 552 3223 1349 1017 M11525 GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. 36/41 Gene Ontology BP GO:1900026 5.50583008139639e-08 2.05617623085131e-07 1845 1356.09090909091 1350 5.00530019926186e-09 454 2.22785742797557 -2.3527986505051 -1 15.9648053161968 1843 552 1776 1030 1122 1936 2022 454 1350 1810 1022 1018 M14895 GO_CELL_MIGRATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_IN_HINDBRAIN.html The orderly movement of a cell that will reside in the hindbrain. 15/24 Gene Ontology BP GO:0021535 1.23267652891705e-07 2.8938667452326e-07 1015 1592.72727272727 1350 1.12061508907713e-08 594 1.41542773122318 1.664735434219 1 9.87497879646179 1014 913 2853 2563 1922 1350 1573 594 1046 2697 995 1019 M11856 GO_REGULATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 296/473 Gene Ontology BP GO:0042391 7.23787380521875e-15 3.62127170061106e-13 3670 2123.63636363636 1351 6.57988527747158e-16 55 2.55583455096069 2.9698693966079 1 34.203757347705 3668 1351 61 376 779 3121 3810 4618 1206 55 4315 1020 M16494 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 17/42 Gene Ontology BP GO:0003071 4.04690110101885e-08 1.97691467186943e-07 4150 2061 1351 3.67900106860148e-09 751 2.52862905377613 -2.25434669158842 -1 18.1819908869415 4148 919 1342 2101 751 4427 4076 846 1351 1324 1386 1021 M11331 GO_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEPARATION.html The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). 17/21 Gene Ontology BP GO:0051304 1.76316046490214e-06 2.29225639653245e-06 1110 1832.81818181818 1353 1.60287443451364e-07 664 1.69641493904014 1.94179352315348 1 10.2122701044806 1110 2010 2839 2338 3548 1353 1172 664 1240 3015 872 1022 M14312 GO_ARGININE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARGININE_METABOLIC_PROCESS.html The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. 14/21 Gene Ontology BP GO:0006525 9.91206705950978e-07 1.39355580331179e-06 2965 1824.63636363636 1353 9.01097411398144e-08 621 3.40324449949882 -3.73258724492429 -1 21.3948811735115 2965 970 1353 749 3271 2522 2922 1048 621 2490 1160 1023 M11897 GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of astrocyte differentiation. 34/50 Gene Ontology BP GO:0048710 9.47903685746761e-08 2.5233974567739e-07 1550 1155.90909090909 1355 8.61730660535132e-09 110 3.04232490016842 3.56038642240997 1 21.5506431648572 1550 1830 973 655 1681 781 1449 1355 110 1867 464 1024 M15924 GO_MODULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 303/448 Gene Ontology BP GO:0050804 3.6721402544888e-12 1.06790428775852e-10 2065 1322.18181818182 1355 3.33830932226812e-13 80 2.49868787277714 2.87936762138411 1 26.7765863615492 2065 1355 113 80 565 1446 2344 2921 703 285 2667 1025 M13556 GO_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ANION_TRANSPORT.html The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 298/504 Gene Ontology BP GO:0015711 1.28761218384124e-09 2.38695597267461e-08 2745 1600.27272727273 1358 1.17055653144986e-10 120 2.37037951561097 -2.19952458451324 -1 19.385810757179 2745 1358 186 1275 986 1278 2102 3210 1574 120 2769 1026 M14737 GO_RESPONSE_TO_PARATHYROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PARATHYROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. 22/27 Gene Ontology BP GO:0071107 1.38354690508166e-07 3.10507150322305e-07 1770 1420.81818181818 1358 1.25776999280987e-08 544 2.54087241391698 3.02938390735651 1 17.7328752019114 1769 823 1358 1390 2015 1447 1171 1152 980 2980 544 1027 M12438 GO_RESPONSE_TO_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. 142/203 Gene Ontology BP GO:0043279 6.27042262136888e-08 2.12948256567067e-07 1700 1331.81818181818 1359 5.70038436371635e-09 631 2.26754778995218 2.73675777092025 1 16.2140097299613 1696 1582 697 1359 1255 1506 1903 985 1874 631 1162 1028 M10786 GO_VESICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. 316/377 Gene Ontology BP GO:0016050 2.05804324571168e-08 1.97691467186943e-07 960 1723.09090909091 1360 1.87094842269469e-09 133 1.69180083337512 -1.34354967381684 -1 12.1273873515012 960 1360 3387 2768 133 323 908 2687 2043 3308 1077 1029 M13786 GO_REGULATION_OF_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP. 26/38 Gene Ontology BP GO:0030823 2.59075459587077e-08 1.97691467186943e-07 1680 1523.09090909091 1360 2.35523147852719e-09 284 2.60626687825477 2.54326390031728 1 18.7437145897427 1677 691 770 1360 284 1313 1475 4048 2576 451 2109 1030 M13278 GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process. 16/23 Gene Ontology BP GO:0070233 2.12477812462441e-06 2.71311542642079e-06 1310 1591.54545454545 1361 1.93161834250491e-07 319 2.89507155755583 -2.66818211350849 -1 17.2792655277386 1306 3193 1509 2132 3613 1309 1361 319 569 1504 692 1031 M14222 GO_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 312/453 Gene Ontology BP GO:0006066 2.29029606849975e-08 1.97691467186943e-07 990 1444 1361 2.08208735667521e-09 191 2.06393503669561 -2.05544466169557 -1 14.819845622092 986 1361 1095 3265 191 692 1640 1134 2172 1863 1485 1032 M16947 GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. 108/199 Gene Ontology BP GO:0002700 5.94848974655555e-07 9.08976117921937e-07 425 1508.72727272727 1361 5.40771941358536e-08 75 1.92082580253465 -1.902890583716 -1 12.4109177345892 423 75 1413 1919 3002 969 2657 1361 3011 992 774 1033 M11612 GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 50/61 Gene Ontology BP GO:0010591 6.91532506944664e-08 2.20844252217812e-07 2360 1545.18181818182 1363 6.28665935165282e-09 147 1.94685153700063 2.60540653876967 1 13.8716660800225 2356 385 2067 302 1363 2834 4019 871 357 2296 147 1034 M15848 GO_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 495/825 Gene Ontology BP GO:0043269 6.21386864224497e-23 1.07085669601355e-20 15 1937.45454545455 1363 5.64897149294997e-24 14 2.55217373698707 2.84291467776675 1 54.892735469266 3364 1256 14 14 768 2882 3575 4279 1363 25 3772 1035 M10386 GO_COGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COGNITION.html The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. 274/419 Gene Ontology BP GO:0050890 5.86435402771801e-08 2.07820558194759e-07 1400 1378 1364 5.33123107639922e-09 655 2.22879320170532 2.56708177487013 1 15.9604260355236 1857 1396 655 1364 1198 1066 2652 1399 1396 927 1248 1036 M12462 GO_PROTEIN_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DESTABILIZATION.html Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. 42/51 Gene Ontology BP GO:0031648 3.66932686495968e-08 1.97691467186943e-07 1365 1979.72727272727 1364 3.33575175105409e-09 303 1.41502740580476 -1.46123117242602 -1 10.1248815417898 1364 2718 3523 3479 641 1277 1135 1074 2706 3557 303 1037 M14574 GO_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT.html The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 158/290 Gene Ontology BP GO:0045165 3.27263609136783e-08 1.97691467186943e-07 2250 1325.36363636364 1364 2.97512376368212e-09 302 2.7157641151846 3.01279382823631 1 19.5359469041819 2246 2183 302 736 506 1364 1734 1885 794 327 2502 1038 M15110 GO_CATECHOLAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_TRANSPORT.html The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 9/17 Gene Ontology BP GO:0051937 6.45624893097872e-07 9.72512990477306e-07 2435 1701.54545454545 1364 6.45625080672123e-08 193 2.54918305170036 -1.84229778460641 -1 16.4271555489554 2435 1079 4535 247 3094 2070 1364 193 516 2437 747 1039 M12320 GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). 41/43 Gene Ontology BP GO:0006891 6.93267367349509e-08 2.20943360292963e-07 205 1976.27272727273 1365 6.30243081087145e-09 91 0.772946527743439 -0.750580845597484 -1 5.43902477579675 202 1802 4059 4431 1365 91 130 577 4250 4449 383 1040 M16738 GO_V_D_J_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_V_D_J_RECOMBINATION.html The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). 14/17 Gene Ontology BP GO:0033151 1.42839176147706e-06 1.90930964267531e-06 1070 1995.36363636364 1367 1.29853880808033e-07 273 1.81659597486053 2.06535409669548 1 11.0994018371016 1070 3810 2893 3134 3452 1238 345 273 1367 3371 996 1041 M13580 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. 122/186 Gene Ontology BP GO:2000379 3.58417236122337e-08 1.97691467186943e-07 3735 1922.36363636364 1369 3.25833856328692e-09 35 2.25531383438461 -2.25293528775261 -1 16.2045058389055 3734 35 691 311 613 4123 4517 2112 2826 815 1369 1042 M13804 GO_EPIBOLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIBOLY.html The expansion of one cell sheet over other cells or yolk. 47/53 Gene Ontology BP GO:0090504 1.04383741200318e-07 2.64253290427139e-07 1110 1655.63636363636 1369 9.48943146845727e-09 278 3.70586568996201 3.60882587978021 1 26.1954456306311 1109 2286 278 1302 3311 1572 1369 3464 554 769 2198 1043 M11136 GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that modulates the frequency, rate or extent of smooth muscle contraction. 54/84 Gene Ontology BP GO:0006940 3.40530903007656e-08 1.97691467186943e-07 1375 1439.81818181818 1371 3.09573552980568e-09 368 2.58646224211994 2.67107387581354 1 18.6004244651547 1371 368 475 2488 548 1540 2771 1092 2870 502 1813 1044 M10578 GO_VESICLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_LOCALIZATION.html Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. 267/339 Gene Ontology BP GO:0051648 2.12561335941815e-08 1.97691467186943e-07 2405 1485.09090909091 1373 1.93237579995961e-09 151 2.08038895708994 -1.74151523278907 -1 14.9388927122387 2403 1380 1073 433 151 1199 1373 3949 454 1628 2293 1045 M11780 GO_DORSAL_VENTRAL_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_PATTERN_FORMATION.html The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 73/135 Gene Ontology BP GO:0009953 1.91193199753364e-08 1.97691467186943e-07 2280 1451.27272727273 1373 1.73812001286316e-09 104 2.30234820325395 2.32012459364176 1 16.5448080049905 2276 219 1180 626 104 1373 2140 3024 955 1662 2405 1046 M13318 GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis. 16/31 Gene Ontology BP GO:1901623 7.97059637825936e-08 2.35175554521502e-07 2235 1249.90909090909 1376 7.24599697003085e-09 119 3.73411480654285 -3.60958308494786 -1 26.6000211553506 2233 885 580 119 1491 2272 1376 1535 198 643 2417 1047 M16704 GO_METAPHASE_PLATE_CONGRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAPHASE_PLATE_CONGRESSION.html The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. 51/51 Gene Ontology BP GO:0051310 7.87080523133776e-08 2.33849999170963e-07 620 1420.63636363636 1376 7.15527773902432e-09 352 1.53591363718635 1.84952268062219 1 10.8785938227804 619 352 3008 2731 1479 1055 708 1411 1376 1644 1244 1048 M13466 GO_BASIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASIC_AMINO_ACID_TRANSPORT.html The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/14 Gene Ontology BP GO:0015802 2.92079273047434e-06 3.60489352119287e-06 1640 1625.09090909091 1377 2.65526964383867e-07 288 2.12661919330486 -2.50130047042736 -1 12.379456745488 1639 2535 2336 1351 3741 1377 735 717 288 1787 1370 1049 M16377 GO_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that modulates the extent to which blood vessels can be pervaded by fluid. 28/38 Gene Ontology BP GO:0043114 1.27804746935884e-07 2.95270847811651e-07 870 1412.90909090909 1377 1.16186140327685e-08 226 2.47515189968114 2.52913853117425 1 17.3296529832335 867 2761 1459 1576 1951 763 749 226 2703 1377 1110 1050 M12181 GO_ESTABLISHMENT_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization or cell growth patterns. 124/172 Gene Ontology BP GO:0030010 2.50824227603995e-08 1.97691467186943e-07 1535 1242.54545454545 1378 2.28022027694243e-09 4 1.93357981817152 2.18362131323128 1 13.8767020381425 1534 4 1760 741 267 1378 1954 2260 662 1195 1913 1051 M16251 GO_REGULATION_OF_CELLULAR_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PH.html Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. 67/95 Gene Ontology BP GO:0030641 4.79811181860175e-07 7.6457583191623e-07 745 1665.63636363636 1378 4.36192078641002e-08 222 1.74479444891532 -1.65282004681332 -1 11.4046482903425 741 1701 2688 3309 2887 521 712 222 3661 1378 502 1052 M12691 GO_SPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 125/149 Gene Ontology BP GO:0006665 1.69686724375964e-08 1.97691467186943e-07 1905 1312.27272727273 1380 1.54260659713421e-09 11 1.87827562171255 -1.78954496665786 -1 13.4765661736461 1902 11 2141 2234 65 808 1960 1306 1380 1121 1507 1053 M14456 GO_MONOCARBOXYLIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_TRANSPORT.html The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 112/209 Gene Ontology BP GO:0015718 4.26099335114286e-08 1.97691467186943e-07 4460 2341.36363636364 1381 3.87363039424585e-09 46 2.69805597012055 -2.64935503642619 -1 19.4078252716926 4457 46 354 1286 804 4192 4307 4615 1381 506 3807 1054 M16887 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. 281/394 Gene Ontology BP GO:0032102 2.87379455481088e-14 1.27350152986048e-12 2390 1437.54545454545 1382 2.61254050437355e-15 70 2.63428615282217 2.97466315430494 1 33.70444286842 2386 1382 70 703 1017 1902 2628 1114 2505 146 1960 1055 M14190 GO_POSITIVE_REGULATION_OF_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GROWTH.html Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. 289/393 Gene Ontology BP GO:0045927 6.03381092865511e-08 2.09987451391415e-07 3795 2216.09090909091 1383 5.48528281285537e-09 501 2.37740056864838 2.34803026711131 1 17.020588485383 3792 1383 501 571 1225 3610 3633 3955 1313 611 3783 1056 M12749 GO_POSITIVE_REGULATION_OF_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 257/394 Gene Ontology BP GO:0043270 1.17861634948652e-17 9.62123135817682e-16 1865 1281.18181818182 1385 1.07146940862411e-18 32 2.68253943433256 2.98927713533608 1 43.3616659819139 1861 1385 32 373 1062 1502 2686 2453 1297 42 1400 1057 M14733 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 79/93 Gene Ontology BP GO:0090003 2.01913025755465e-08 1.97691467186943e-07 4460 2206.72727272727 1385 1.83557297825997e-09 127 2.43358127687144 -2.26175108985036 -1 17.4943030293222 4456 191 1222 607 127 4196 4485 3266 571 1385 3768 1058 M12447 GO_EATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EATING_BEHAVIOR.html The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. 21/46 Gene Ontology BP GO:0042755 7.11843084434685e-08 2.23814099129341e-07 4620 2345.09090909091 1387 6.47130097697672e-09 268 2.64840851500874 -1.62171485931022 -1 18.8945588843212 4620 782 1088 268 1387 4467 4647 2595 488 1282 4172 1059 M11086 GO_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. 254/310 Gene Ontology BP GO:0007009 3.82734848149453e-08 1.97691467186943e-07 310 2252.09090909091 1388 3.47940777098096e-09 307 2.253162532336 2.72203823675423 1 16.1889407794683 3932 1388 307 400 681 4302 3936 4004 906 307 4610 1060 M10997 GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that activates or increases the frequency, rate, or extent of cellular extravasation. 10/16 Gene Ontology BP GO:0002693 7.13116551215464e-08 2.23814099129341e-07 1950 1332.09090909091 1389 6.48287794846093e-09 616 2.66552073781225 2.72893667095077 1 19.0173734925222 1950 1048 1408 616 1389 1693 978 885 2079 1071 1536 1061 M16445 GO_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of cell proliferation. 1488/2183 Gene Ontology BP GO:0042127 3.00505824796726e-12 8.90607390305202e-11 1430 1550 1389 3.00505824797132e-13 73 2.2228161611601 2.45866851445362 1 23.9969332904787 1427 1148 4624 1276 696 949 1762 1389 2122 73 1584 1062 M11388 GO_MONOVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 289/504 Gene Ontology BP GO:0015672 8.09873276888977e-08 2.36407801591243e-07 1100 1334.63636363636 1390 7.36248460638522e-09 425 2.35925557835012 -2.06486784468467 -1 16.7587712531104 1096 2138 425 1823 1510 1132 1390 947 1555 497 2168 1063 M12446 GO_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that modulates the activity of a transporter. 198/288 Gene Ontology BP GO:0032409 2.69948877347133e-08 1.97691467186943e-07 2230 1461.18181818182 1391 2.45408073326832e-09 91 2.4008288134809 2.64208379145012 1 17.2573330326081 2230 1458 299 91 324 1391 2150 4549 1322 271 1988 1064 M10784 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_EPITHELIAL_CELL_APICAL_BASAL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. 36/48 Gene Ontology BP GO:0045197 8.04694731628651e-08 2.35603100974214e-07 2390 1602.90909090909 1392 7.31540691874543e-09 200 2.69443786694131 3.5328595881433 1 19.160084101169 2388 539 1355 737 1504 2800 1587 4247 200 883 1392 1065 M16170 GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. 55/62 Gene Ontology BP GO:0060603 1.52832778263426e-07 3.30297685675671e-07 2210 1559.72727272727 1392 1.38938898982396e-08 262 3.15967744999148 3.41783621892117 1 21.987585927468 2209 2689 751 262 2098 1347 1392 3126 493 1369 1421 1066 M12284 GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. 24/25 Gene Ontology BP GO:1901798 1.87092909866016e-08 1.97691467186943e-07 1380 2087.27272727273 1393 1.70084464960997e-09 95 1.82323238145086 2.0791671654955 1 13.0783183744373 1377 3987 2901 3935 95 1228 396 1393 3459 2879 1310 1067 M12564 GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS.html The cellular component assembly that is part of the initial shaping of the component during its developmental progression. 274/381 Gene Ontology BP GO:0010927 2.76909811463814e-08 1.97691467186943e-07 1395 1291.90909090909 1393 2.51736195408386e-09 347 2.0755339798109 2.24860223926643 1 14.9037660734835 1490 1393 1114 2055 347 1513 1840 744 696 1391 1628 1068 M14294 GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_POSITIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. 67/211 Gene Ontology BP GO:0050830 1.34357123092144e-07 3.04253649162657e-07 785 1623.72727272727 1394 1.22142846634113e-08 270 2.14546439371698 -2.1214611604648 -1 14.9761616753377 785 270 1000 2328 1997 1037 1598 2993 3407 1052 1394 1069 M15449 GO_KERATINIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINIZATION.html The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. 26/66 Gene Ontology BP GO:0031424 3.91874826516761e-08 1.97691467186943e-07 2690 1788.72727272727 1394 3.56249848633662e-09 350 3.64699932447336 -3.68593213860494 -1 26.2736020800367 2689 655 350 1295 712 2215 1394 4081 2930 578 2777 1070 M12910 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. 67/120 Gene Ontology BP GO:0002708 4.69591257169747e-07 7.52154258041594e-07 905 1876.27272727273 1396 4.26901234003908e-08 244 1.57806177966427 -1.48599928267573 -1 10.3161269578478 904 244 2467 2357 2871 930 1396 3600 3847 1049 974 1071 M16674 GO_FILOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FILOPODIUM_ASSEMBLY.html The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. 21/22 Gene Ontology BP GO:0046847 5.57895427673781e-08 2.05617623085131e-07 4450 2254.27272727273 1398 5.07177674383077e-09 539 2.25984827883157 -2.30143175390903 -1 16.1956754744116 4448 748 1398 539 1136 4249 4100 2891 824 796 3668 1072 M13612 GO_MEIOTIC_CHROMOSOME_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEPARATION.html The process in which chromosomes are physically detached from each other during meiosis. 9/12 Gene Ontology BP GO:0051307 1.93943260578788e-05 2.16199806294466e-05 1220 2221.45454545455 1399 1.93944953229054e-06 537 1.83220273384791 2.05335252861548 1 9.11162354324114 1219 3270 4438 2799 4176 1345 537 615 1399 3535 1103 1073 M13613 GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCINEURIN_NFAT_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. 19/24 Gene Ontology BP GO:0070884 5.31480037724896e-08 2.04903449305918e-07 3385 1783.18181818182 1401 4.83163682331352e-09 779 2.50219885129358 -2.29616014650595 -1 17.9487409305643 3383 861 1521 1233 1080 2399 2479 3591 1401 779 888 1074 M12623 GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. 57/98 Gene Ontology BP GO:0071384 6.67795113132354e-08 2.18361447198576e-07 860 1752.45454545455 1403 6.07086484911657e-09 168 2.52308671368253 2.33580923968156 1 18.0242902555624 856 3370 1250 2363 1323 401 168 2607 2801 2735 1403 1075 M12859 GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT.html The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. 34/54 Gene Ontology BP GO:0048566 5.40514807307115e-07 8.40861049281179e-07 1385 1769.81818181818 1403 4.91377218277691e-08 860 3.06753590713847 3.32268764449587 1 19.9995967615539 1382 2344 860 1403 2955 1565 1159 3469 2458 901 972 1076 M13373 GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. 44/58 Gene Ontology BP GO:0030514 7.73410200907533e-08 2.30980594661281e-07 2305 1300.27272727273 1403 7.03100207360708e-09 300 2.30449132956629 2.45291862550868 1 16.3922182444163 779 2304 1639 2302 1468 716 1465 819 1108 1403 300 1077 M16575 GO_POSITIVE_REGULATION_OF_AXONOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXONOGENESIS.html Any process that activates or increases the frequency, rate or extent of axonogenesis. 93/107 Gene Ontology BP GO:0050772 7.72189534416798e-08 2.30947065667097e-07 690 1443 1404 7.01990510472986e-09 536 2.37244484246172 2.82080592212343 1 16.8790789183608 690 2650 1248 2526 1465 727 1404 536 1737 2262 628 1078 M10397 GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 168/214 Gene Ontology BP GO:0046488 7.25852529331559e-08 2.2546006802268e-07 1170 1511.81818181818 1405 6.59865957527118e-09 168 1.78858180486243 -1.68533645464379 -1 12.7174307168799 1166 1533 2451 2299 1405 168 1112 1666 1223 3423 184 1079 M13475 GO_RESPONSE_TO_ESTROGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ESTROGEN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 256/351 Gene Ontology BP GO:0043627 1.39502878403783e-08 1.97691467186943e-07 1715 1411.27272727273 1405 1.2682079935307e-09 223 2.45814233720372 2.44673532046891 1 17.6720067432944 1713 1405 223 540 651 1173 2307 2964 1540 434 2574 1080 M15725 GO_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_NUCLEATION.html The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. 22/25 Gene Ontology BP GO:0045010 1.57738279107795e-07 3.36831671724905e-07 2035 1628.90909090909 1405 1.43398445834097e-08 306 1.72020334889305 -1.99226832969679 -1 11.9032447371763 2032 788 2757 1383 2127 2392 1405 637 306 2982 1109 1081 M10229 GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. 168/229 Gene Ontology BP GO:0043524 7.1625892131076e-08 2.23824899990528e-07 2220 1529.90909090909 1408 6.51144495118329e-09 647 2.19968719716181 2.43725858994448 1 15.6740313782189 2216 1537 1158 647 1397 1974 2060 1035 949 1408 2448 1082 M13633 GO_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIVISION.html Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. 289/381 Gene Ontology BP GO:0051302 7.28567948358647e-08 2.25729558068868e-07 845 1360.27272727273 1408 6.62334520442209e-09 756 2.0058746199515 2.28149395052433 1 14.2750742534975 843 1379 1467 1867 1408 756 1151 2150 1481 865 1596 1083 M15391 GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 22/39 Gene Ontology BP GO:0032891 4.66760027598261e-07 7.49166750056816e-07 580 1329 1408 4.24327387843456e-08 195 3.26178865617432 3.30292472215741 1 21.4497642333662 579 1935 1155 1549 2863 1022 579 1534 195 1800 1408 1084 M12654 GO_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. 141/246 Gene Ontology BP GO:0048469 7.29145767843344e-08 2.25729558068868e-07 1930 1421.72727272727 1409 6.62859810917649e-09 200 2.35889654568319 2.42164437862342 1 16.8073063849231 1928 1580 574 200 1409 895 1635 3259 954 549 2656 1085 M16687 GO_HETEROTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROTYPIC_CELL_CELL_ADHESION.html The attachment of a cell to a cell of a different type via adhesion molecules. 26/46 Gene Ontology BP GO:0034113 4.83107820677431e-07 7.69038894838209e-07 505 1692.72727272727 1409 4.3918902433206e-08 504 2.21084695230685 2.29210906714211 1 14.4751252158094 504 701 1409 2063 2890 1108 1012 1877 4005 922 2129 1086 M11555 GO_REGULATION_OF_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLERANCE_INDUCTION.html Any process that modulates the frequency, rate, or extent of tolerance induction. 28/59 Gene Ontology BP GO:0002643 1.79639977997297e-06 2.32848528762706e-06 190 1835.27272727273 1410 1.63309204256049e-07 187 1.49804494573121 -1.54705410447297 -1 8.99386449911369 187 666 2694 3357 3558 612 548 1022 3410 2724 1410 1087 M11702 GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND http://www.broadinstitute.org/gsea/msigdb/cards/GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND.html A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. 34/47 Gene Ontology BP GO:0001702 1.01086526691061e-06 1.41716061673248e-06 1410 1760.90909090909 1410 9.1896884671595e-08 662 2.5053192571484 3.25909949900166 1 15.700408944752 1410 3417 2037 2150 3281 1202 691 662 1210 2501 809 1088 M12279 GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE.html Any process that modulates the size of an anatomical structure. 492/671 Gene Ontology BP GO:0090066 1.29854676420074e-15 7.55267261728253e-14 1905 1336.09090909091 1410 1.1804970583643e-16 50 2.42953336472322 2.73587909299738 1 34.2929014673719 1904 1269 50 386 259 2046 3060 1932 1410 158 2223 1089 M10254 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 94/124 Gene Ontology BP GO:1903845 4.26471038110119e-08 1.97691467186943e-07 1345 1914.54545454545 1411 3.87700951252074e-09 133 1.88594850419445 2.31952542099825 1 13.532080866231 1342 4369 2552 2608 805 738 1411 281 3261 3560 133 1090 M15495 GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. 32/33 Gene Ontology BP GO:0033627 1.38955699567413e-05 1.57314080313181e-05 20 1601.63636363636 1411 1.26324161129763e-06 18 3.61059142688335 3.64386571781653 1 18.6034847734957 18 2343 449 1411 4145 1157 1482 2021 2135 1083 1374 1091 M12547 GO_ETHANOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHANOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. 13/17 Gene Ontology BP GO:0006067 3.77669581991383e-07 6.35757200702908e-07 1415 1587.27272727273 1412 3.43336042568343e-08 1124 3.00702171275278 -3.25577771619123 -1 19.996910653159 1412 2022 1124 1335 2729 1404 1438 1796 1382 1330 1488 1092 M15113 GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. 94/124 Gene Ontology BP GO:0030512 4.26471038110119e-08 1.97691467186943e-07 1345 1936.54545454545 1412 3.87700951252074e-09 134 1.88594850419445 2.31952542099825 1 13.532080866231 1343 4370 2553 2609 806 739 1412 513 3262 3561 134 1093 M16048 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 27/29 Gene Ontology BP GO:0010662 5.28644576428404e-07 8.26445890038337e-07 2495 1646.27272727273 1412 4.80586094052757e-08 208 2.53088266787885 2.56995556447752 1 16.501473007869 2491 717 1312 1412 2941 2411 1765 208 2369 1237 1246 1094 M13699 GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 10/17 Gene Ontology BP GO:0010759 3.75267462909827e-07 6.3288129935463e-07 480 1615.63636363636 1417 3.41152297201373e-08 58 2.81234462740986 2.83203743843147 1 18.7009483228078 477 2558 1417 2331 3277 1235 850 58 3560 1569 440 1095 M11462 GO_DETECTION_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_OTHER_ORGANISM.html The series of events in which a stimulus from another organism is received and converted into a molecular signal. 31/63 Gene Ontology BP GO:0098543 2.27610730588842e-06 2.88497066039194e-06 135 1968.09090909091 1419 2.06919060067211e-07 133 1.35837649452388 -1.34544850127767 -1 8.00834984209567 133 645 2988 3446 3641 533 717 1256 4404 2467 1419 1096 M10465 GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 55/64 Gene Ontology BP GO:0071364 1.16726619134076e-07 2.8188840060211e-07 1770 1509.36363636364 1420 1.06115113933914e-08 318 2.73860568592751 2.99837720745299 1 19.2457851441979 1768 318 562 628 1866 1420 2490 2713 529 1176 3133 1097 M12822 GO_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 209/316 Gene Ontology BP GO:1901654 5.02349448451423e-08 2.02375063519002e-07 1815 1417.45454545455 1420 4.56681327201911e-09 514 2.31825711164186 2.41391111881521 1 16.6344694630912 1815 1468 573 1166 1016 1233 1420 1560 2614 514 2213 1098 M15119 GO_OSTEOBLAST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOBLAST_DEVELOPMENT.html The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. 24/31 Gene Ontology BP GO:0002076 4.67436498205151e-08 1.98236457419581e-07 2780 1659.63636363636 1422 4.24942280124389e-09 259 2.70648477928736 -2.54074414030818 -1 19.4653169642107 2778 709 1079 259 942 2359 2393 4194 470 1422 1651 1099 M11909 GO_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSPORT.html The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 215/370 Gene Ontology BP GO:0015849 6.59079104826429e-11 1.57266414090122e-09 2760 1452.18181818182 1423 5.99162822587431e-12 123 2.53874291450792 -2.35729046363756 -1 24.007162558915 2756 1423 144 875 865 1449 2230 2664 959 123 2486 1100 M13607 GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. 20/22 Gene Ontology BP GO:0034315 6.77893448582382e-08 2.19879876316322e-07 530 1696.81818181818 1423 6.16266790427766e-09 126 1.43161172384991 -1.5046972283396 -1 10.1734949850124 530 1948 3146 2018 1339 384 126 3027 1423 3919 805 1101 M14028 GO_NEURON_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_CELL_CELL_ADHESION.html The attachment of a neuron to another cell via adhesion molecules. 13/22 Gene Ontology BP GO:0007158 5.99615707431109e-07 9.14158547403981e-07 1630 1500.54545454545 1423 5.45105337143626e-08 76 3.9630516993142 3.32104862641021 1 25.7159161198122 1626 936 514 492 3009 1753 1423 3052 76 696 2929 1102 M16041 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 98/140 Gene Ontology BP GO:0090100 8.98107139402898e-08 2.4768192782905e-07 2125 1485.27272727273 1423 8.16461069151247e-09 94 2.43811670645075 2.5720459038442 1 17.2694973398579 2121 94 647 126 1617 1827 1982 4245 1178 1078 1423 1103 M12662 GO_NEURAL_NUCLEUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_NUCLEUS_DEVELOPMENT.html The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. 100/153 Gene Ontology BP GO:0048857 4.8178714866259e-08 1.990761933901e-07 3015 2045.63636363636 1424 4.37988326557679e-09 463 2.26716762465487 2.63234905043433 1 16.2828529220809 3011 2221 1424 1148 980 4476 4272 1128 988 2391 463 1104 M16354 GO_REGULATION_OF_ORGAN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of organ morphogenesis. 239/309 Gene Ontology BP GO:2000027 4.27432745868291e-08 1.97691467186943e-07 1780 1366.09090909091 1425 3.88575231066163e-09 217 2.17845044697805 2.53751179800098 1 15.6483853283966 1779 1425 947 217 809 1688 2175 2148 978 1223 1638 1105 M16849 GO_RESPONSE_TO_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. 94/150 Gene Ontology BP GO:0014823 3.28815469149415e-08 1.97691467186943e-07 1430 1438.45454545455 1426 2.98923158239947e-09 134 2.51023465936264 2.69911393190883 1 18.048904116284 1953 134 936 1426 514 2124 1426 3057 1022 1417 1814 1106 M13574 GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 73/111 Gene Ontology BP GO:0051588 6.68847826313751e-08 2.18361447198576e-07 2555 1734.81818181818 1429 6.08043496952891e-09 206 2.04867801469471 2.23215716552875 1 14.6139696480309 2552 206 1429 1043 1326 2487 3491 1210 1981 1278 2080 1107 M13624 GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 20/24 Gene Ontology BP GO:0051043 2.49921793990108e-07 4.61462741046021e-07 1280 1480.18181818182 1430 2.27201656710393e-08 176 2.14157333817931 -1.64473611935376 -1 14.5306878160954 1279 785 1430 1860 2475 1047 176 2037 427 1852 2914 1108 M12619 GO_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYMERIZATION.html The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. 74/96 Gene Ontology BP GO:0051258 1.94821970982134e-07 3.90735616801668e-07 1435 1376.45454545455 1432 1.77110898395165e-08 425 2.13868710914084 -2.24780699435468 -1 14.6777235841674 1432 1683 1644 1851 2281 821 1079 652 425 2617 656 1109 M14668 GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. 243/297 Gene Ontology BP GO:2001234 3.26740890062278e-08 1.97691467186943e-07 1435 1528.09090909091 1433 2.97037177195443e-09 502 2.05656391334177 2.28400628063726 1 14.7665142113791 1226 1433 1364 1437 502 792 1432 2767 1794 2417 1645 1110 M12413 GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 69/99 Gene Ontology BP GO:0070167 6.80282269038094e-08 2.20228333272585e-07 1870 1277.45454545455 1434 6.18438445521574e-09 188 3.14376458607519 3.58541056787805 1 22.4735330596405 1866 1694 400 1852 1342 1434 1780 188 1826 907 763 1111 M12435 GO_MITOTIC_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis. 49/58 Gene Ontology BP GO:0090307 4.07617217916587e-07 6.73523762416861e-07 1590 1401.63636363636 1434 3.70561175854682e-08 389 1.94449505022659 2.0056331292721 1 12.8384756819124 1590 389 1968 1357 2777 1919 1606 793 474 1434 1111 1112 M15806 GO_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECONDARY_METABOLIC_PROCESS.html The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. 34/78 Gene Ontology BP GO:0019748 8.70642719206984e-08 2.45512816355666e-07 1435 1546.81818181818 1434 7.9149341242035e-09 567 2.66817673317628 -2.77687381708009 -1 18.9207146918787 1434 567 1022 1114 1576 1661 2376 1835 3299 1068 1063 1113 M10730 GO_NADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. 32/41 Gene Ontology BP GO:0006739 1.56702659625754e-07 3.35441855270951e-07 690 1809.81818181818 1435 1.42456973443134e-08 602 1.64934196895285 -1.77334000845862 -1 11.4114445859176 686 602 2608 3285 2120 1195 1315 1056 4002 1604 1435 1114 M12017 GO_ORGANOPHOSPHATE_ESTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_ESTER_TRANSPORT.html The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. 80/106 Gene Ontology BP GO:0015748 7.51966964099953e-08 2.28689428729205e-07 1845 1710.81818181818 1435 6.83606354365838e-09 183 1.77265397390274 -1.62125303225638 -1 12.5913550007062 1845 183 2376 4084 1435 750 1246 1477 3287 1130 1006 1115 M12603 GO_RESPONSE_TO_PROSTAGLANDIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROSTAGLANDIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 49/107 Gene Ontology BP GO:0034694 5.67691331400743e-08 2.0634742747708e-07 1435 1634.09090909091 1435 5.16083041863215e-09 422 2.59461548076406 2.79904014882495 1 18.6072998960641 2283 422 980 1762 1159 2081 1169 1435 2929 1435 2320 1116 M16553 GO_SIALYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIALYLATION.html The covalent attachment of sialic acid to a substrate molecule. 12/21 Gene Ontology BP GO:0097503 1.78350154380994e-06 2.31702237076397e-06 425 1463.09090909091 1435 1.62136635424101e-07 327 2.6703421594212 2.82411783413838 1 16.1267075023843 425 2047 1435 1878 3550 929 891 327 1754 2029 829 1117 M16925 GO_DIVALENT_INORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_TRANSPORT.html The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 214/346 Gene Ontology BP GO:0072511 4.01152590516531e-08 1.97691467186943e-07 1795 1336.09090909091 1435 3.64684179846573e-09 253 2.35685103647655 2.6014025251329 1 16.9391458615257 1794 1435 258 1285 737 1262 2171 1748 1744 253 2010 1118 M13120 GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS.html Any microtubule cytoskeleton organization that is involved in mitosis. 49/58 Gene Ontology BP GO:1902850 4.07617217916587e-07 6.73523762416861e-07 1595 1387.36363636364 1436 3.70561175854682e-08 390 1.94449505022659 2.0056331292721 1 12.8384756819124 1591 390 1969 1358 2778 1920 1607 625 475 1436 1112 1119 M13197 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 71/84 Gene Ontology BP GO:2001239 8.60441278943921e-08 2.44720860081055e-07 100 1008.63636363636 1436 7.82219375087829e-09 52 2.80613308518603 2.99133628118661 1 19.9090951264337 100 2262 612 1436 1563 52 121 1515 1584 1698 152 1120 M12384 GO_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that modulates the frequency, rate, or extent of a homeostatic process. 468/664 Gene Ontology BP GO:0032844 8.03796521761423e-08 2.35520479581606e-07 2410 1384.63636363636 1437 7.30724137390089e-09 187 2.18040410475518 2.36663118658169 1 15.4835842818674 1491 1285 360 187 1502 1437 1407 2410 2408 324 2420 1121 M11762 GO_MICROTUBULE_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_PROCESS.html Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. 549/703 Gene Ontology BP GO:0007017 6.84335797040139e-08 2.20507296091218e-07 1170 1817.72727272727 1438 6.84335818114337e-09 1035 1.73809526887438 1.96659811478537 1 12.3733569809314 1168 1251 4323 2696 1438 1035 1781 1509 1388 1972 1434 1122 M13189 GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of stem cell differentiation. 71/92 Gene Ontology BP GO:2000738 7.76318370130755e-07 1.13306442164944e-06 1430 1719.90909090909 1438 7.05744221883542e-08 857 2.30513120200649 2.86524931001796 1 14.6785502896473 1438 2258 1150 1429 3154 1281 1874 1428 1474 2576 857 1123 M15529 GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_MORPHOGENESIS_IN_CAMERA_TYPE_EYE.html The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 27/44 Gene Ontology BP GO:0002089 3.6957857307797e-08 1.97691467186943e-07 2190 1100.27272727273 1438 3.35980526624118e-09 6 2.52678167305579 3.62196728003762 1 18.1686247532858 2189 714 1438 274 648 1826 1464 1581 88 1875 6 1124 M11155 GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level. 81/125 Gene Ontology BP GO:0044259 2.85341995868715e-16 1.89670900968162e-14 185 1298.72727272727 1440 2.59401814426105e-17 42 3.53685698266672 3.54704058476092 1 52.2649728689424 183 1645 42 1279 3326 1490 1337 1440 1613 336 1595 1125 M15793 GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITIC_SPINE_MORPHOGENESIS.html Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 20/22 Gene Ontology BP GO:0061003 1.09661786686568e-07 2.70288255990805e-07 305 1468.81818181818 1441 9.96925383207265e-09 113 2.10490209558073 2.42495519772327 1 14.8076668535826 304 2452 2205 3149 1818 932 269 113 1441 2257 1217 1126 M12343 GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. 58/66 Gene Ontology BP GO:1900024 3.26554786706138e-08 1.97691467186943e-07 3905 2108 1442 2.96867992321201e-09 309 2.10254873965253 -2.25210839115371 -1 15.0992227472174 3902 309 1442 1169 501 4500 4350 2518 1215 1409 1873 1127 M14871 GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. 39/42 Gene Ontology BP GO:0045839 2.75895739347454e-07 4.96228401694512e-07 700 1749 1442 2.50814339951599e-08 550 1.79394821844393 1.94529595644334 1 12.0926010385292 574 3085 3110 2912 2544 700 577 550 1442 3045 700 1128 M10099 GO_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMORY.html The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). 103/156 Gene Ontology BP GO:0007613 6.97428963658191e-08 2.21209063933304e-07 1445 1493.72727272727 1443 6.34026350697826e-09 604 2.55511416046306 2.97598604222728 1 18.2390051687596 1443 2223 898 1734 1373 1276 2202 604 1752 1525 1401 1129 M10576 GO_HEART_TRABECULA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_MORPHOGENESIS.html The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. 34/39 Gene Ontology BP GO:0061384 5.86643400406461e-06 6.91751581878171e-06 520 1654.90909090909 1443 5.3331360430242e-07 95 2.43101407768655 2.79214604804881 1 13.4249479904043 517 3688 1443 3085 4093 297 95 232 2238 2154 362 1130 M16624 GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of cation transmembrane transport. 207/316 Gene Ontology BP GO:1904062 3.77575069247187e-08 1.97691467186943e-07 3560 2021.18181818182 1443 3.43250068843018e-09 77 2.3521735300405 2.57947134001213 1 16.9053032564194 3557 1443 295 77 666 3456 4093 4055 1166 166 3259 1131 M16782 GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 333/547 Gene Ontology BP GO:0034762 1.47952195045224e-13 5.71826221194794e-12 85 1832.81818181818 1443 1.34501995495667e-14 44 2.50383258897945 2.69193343639441 1 30.2671914469848 2941 1337 82 44 943 2302 3279 4553 1443 83 3154 1132 M16907 GO_CORPUS_CALLOSUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORPUS_CALLOSUM_DEVELOPMENT.html The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. 24/36 Gene Ontology BP GO:0022038 1.15672540218406e-06 1.59190869457629e-06 810 1670.72727272727 1444 1.05156910033867e-07 323 2.2823744109189 3.0154269567326 1 14.168797318416 808 3452 2112 1444 3346 896 502 1082 1528 2885 323 1133 M15854 GO_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_MEDIATED_ENDOCYTOSIS.html An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. 204/399 Gene Ontology BP GO:0006898 1.96006366451627e-08 1.97691467186943e-07 3495 2142.36363636364 1445 1.78187607452658e-09 115 2.37334266025754 2.61747689931322 1 17.0584657424944 3494 1445 273 679 115 4094 4210 3445 1378 510 3923 1134 M16443 GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. 42/48 Gene Ontology BP GO:0035924 2.4005579576882e-07 4.47507859660384e-07 850 1519.54545454545 1445 2.18232565420743e-08 341 1.8084555303582 1.86883219243957 1 12.2789022027171 847 498 2289 1445 2451 358 341 952 3096 2528 1910 1135 M10562 GO_REGULATION_OF_PODOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PODOSOME_ASSEMBLY.html Any process that modulates the frequency, rate or extent of podosome assembly. 22/27 Gene Ontology BP GO:0071801 2.35761051354747e-07 4.41848711172251e-07 2445 1641.63636363636 1446 2.14328251472614e-08 318 2.67132373062801 -2.84770686887256 -1 18.2074302541676 2445 774 1291 554 2431 3222 2325 946 318 1446 2306 1136 M12819 GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 210/257 Gene Ontology BP GO:0051495 3.87641062890752e-08 1.97691467186943e-07 1730 1515.54545454545 1447 3.52400972473642e-09 700 2.04327896046284 2.38070687997799 1 14.6703951743916 1728 1447 1362 1025 700 1812 3305 1203 1473 1599 1017 1137 M13416 GO_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_URINE_VOLUME.html Any process that modulates the amount of urine excreted from the body over a unit of time. 18/30 Gene Ontology BP GO:0035809 6.25108712034577e-07 9.45588698666089e-07 1490 1766.63636363636 1447 5.68280808775672e-08 803 2.93413193434489 2.92649183150986 1 18.9634889851818 1489 1975 1058 2716 3037 1372 803 1447 3135 1167 1234 1138 M10649 GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. 77/130 Gene Ontology BP GO:2000106 4.739840562096e-08 1.98252330758246e-07 3380 1879 1448 4.30894605837688e-09 208 2.54948694850865 2.476989343751 1 18.3295161615585 3378 208 739 821 961 2894 2198 3098 1448 857 4067 1139 M12649 GO_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASOCONSTRICTION.html A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure. 22/39 Gene Ontology BP GO:0042310 1.25852957525248e-05 1.43176970993883e-05 825 1643.27272727273 1448 1.14412434076415e-06 472 4.29512758150236 5.01135273648017 1 22.3415465572729 2254 825 657 1157 4069 2824 1845 1704 821 1448 472 1140 M15466 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. 213/264 Gene Ontology BP GO:0031110 9.616046907324e-08 2.53938011162528e-07 1450 1553.90909090909 1448 8.74186120694070e-09 1039 1.78817443960342 2.0149317301752 1 12.6148158907563 1252 1448 2500 2248 1697 1178 1585 1464 1236 1039 1446 1141 M10678 GO_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 219/292 Gene Ontology BP GO:0002064 6.69330578612641e-08 2.18361447198576e-07 3350 1981.90909090909 1449 6.08482362705848e-09 406 2.57553475808381 2.82428071418081 1 18.40131674565 3347 1449 406 459 1328 2593 2685 4242 909 522 3861 1142 M15735 GO_COLLECTING_DUCT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLLECTING_DUCT_DEVELOPMENT.html The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. 18/27 Gene Ontology BP GO:0072044 7.10637469430418e-08 2.23814099129341e-07 3950 2113.63636363636 1449 6.46034083986562e-09 44 2.93910287250461 3.94659667719435 1 20.9808754331434 3948 892 1449 232 1385 3733 3201 1103 44 2767 4496 1143 M11471 GO_MANGANESE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANGANESE_ION_TRANSPORT.html The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/14 Gene Ontology BP GO:0006828 9.39628214242768e-08 2.51115998606105e-07 1455 1681.81818181818 1451 9.39628253973323e-09 15 2.956938873902 -3.06843441938776 -1 20.9493652059669 1451 2085 4305 1355 3084 1338 401 25 15 2925 1516 1144 M12129 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition. 26/30 Gene Ontology BP GO:1902751 7.62292722382377e-08 2.29724613811218e-07 755 2028.81818181818 1451 6.9299340799597e-09 755 1.35393338200029 1.61207867189686 1 9.58755585066318 755 2399 3289 2845 1451 1396 1096 3106 1229 3417 1334 1145 M13112 GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). 45/111 Gene Ontology BP GO:0007200 9.87140259633557e-08 2.57032100060153e-07 4150 1900.72727272727 1451 8.97400276296869e-09 325 2.95805010420136 -3.12989937729174 -1 20.9249956754369 4149 395 325 1102 1722 3736 3063 889 1451 385 3691 1146 M14854 GO_PHARYNGEAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHARYNGEAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. 22/36 Gene Ontology BP GO:0060037 2.92049116987979e-06 3.60489352119287e-06 2635 1916.18181818182 1451 2.65499549711573e-07 717 2.79463841879547 3.29010928076606 1 16.3036508649574 2634 771 925 1373 3740 2676 2124 3851 717 1451 816 1147 M15840 GO_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTION.html The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. 1178/2036 Gene Ontology BP GO:0000003 4.83887171322126e-08 1.9910893664146e-07 835 1597.18181818182 1451 4.83887181858731e-09 470 2.15332422480493 2.16569223604058 1 15.4593817938661 832 2100 4575 1826 1084 470 993 1451 1928 486 1824 1148 M10842 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. 52/89 Gene Ontology BP GO:0002720 1.1782929459885e-06 1.61537922147452e-06 290 1676.27272727273 1452 1.0711759791529e-07 287 1.78770438636759 -1.57823794236501 -1 11.0611496874954 287 345 1452 1602 3358 368 1695 3899 3465 1101 867 1149 M12038 GO_SPECIFICATION_OF_SYMMETRY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPECIFICATION_OF_SYMMETRY.html The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. 132/206 Gene Ontology BP GO:0009799 2.64832971149526e-08 1.97691467186943e-07 1535 1554.90909090909 1453 2.40757249397771e-09 302 2.04835945960989 2.12942296859376 1 14.707153504653 1531 2205 1453 2778 302 1280 2341 1245 2137 1007 825 1150 M10113 GO_LIPID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_MODIFICATION.html The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. 198/244 Gene Ontology BP GO:0030258 1.84058403441882e-08 1.97691467186943e-07 1925 1278.54545454545 1454 1.67325822710698e-09 90 1.87291841916856 -1.69560200177896 -1 13.4378058442593 1924 1454 1689 1126 90 547 2191 1647 759 1990 647 1151 M10314 GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 17/18 Gene Ontology BP GO:0043517 2.99801186820489e-08 1.97691467186943e-07 635 1900.72727272727 1454 2.72546537187253e-09 287 2.03542627883971 2.04650484479119 1 14.6135796024988 635 4020 2629 3915 407 888 287 746 3335 2592 1454 1152 M13305 GO_VACUOLAR_ACIDIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLAR_ACIDIFICATION.html Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. 16/18 Gene Ontology BP GO:0007035 7.84360167363521e-08 2.33650951263922e-07 175 1106.81818181818 1455 7.13054723025554e-09 39 1.75571676364011 -1.75558989064656 -1 12.4523049867606 174 1989 2557 2293 1476 158 41 70 1455 1923 39 1153 M16971 GO_BRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). 33/55 Gene Ontology BP GO:0048854 2.58030548877434e-07 4.7126800805796e-07 290 1531.27272727273 1455 2.34573253764517e-08 289 2.36133362576725 2.79112940978109 1 16.0101081144605 1731 609 1259 289 2506 2428 3419 290 1131 1727 1455 1154 M11713 GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 137/200 Gene Ontology BP GO:0034764 3.57097213911022e-09 6.22312110984264e-08 1990 1428.63636363636 1456 3.24633831355138e-10 187 2.67377475645246 2.74148215618266 1 20.6806698264965 1986 1563 197 409 1160 1588 2852 3460 857 187 1456 1155 M16892 GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. 14/20 Gene Ontology BP GO:0042789 3.44665454788033e-08 1.97691467186943e-07 965 1956.36363636364 1457 3.13332236534339e-09 562 2.20135499071308 2.42751041924572 1 15.8141038451661 964 3538 2282 3677 562 1457 737 1298 3194 2964 847 1156 M14743 GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. 78/129 Gene Ontology BP GO:0002702 6.30829397554139e-07 9.53312499778957e-07 3040 1743.90909090909 1458 5.73481434944212e-08 192 1.86167962957148 -1.760813831209 -1 11.9837220033207 488 192 1458 2307 3040 897 2299 3036 3244 1171 1051 1157 M15914 GO_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. 492/738 Gene Ontology BP GO:0030855 5.76547375767967e-23 1.03179805363398e-20 15 1894.36363636364 1459 5.24133977970878e-24 13 2.73236464537321 2.9877967320814 1 58.8238923265619 3207 1271 13 13 469 2246 3801 3735 1459 103 4521 1158 M10703 GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS.html The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 182/306 Gene Ontology BP GO:0050954 3.28769418822251e-18 2.8863473693961e-16 2185 1370.72727272727 1463 2.98881289838408e-19 29 3.00324526715231 3.38023615146076 1 50.2539712575793 2182 1463 29 363 1063 2048 2584 2706 485 93 2062 1159 M10982 GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 33/54 Gene Ontology BP GO:0090184 7.35061900718169e-08 2.26356255727441e-07 2180 1619.36363636364 1463 6.6823811388908e-09 505 2.70324660634894 2.68264382164661 1 19.2738222954484 2177 1823 878 505 1417 1463 1526 3802 774 1201 2247 1160 M15042 GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of muscle tissue development. 64/88 Gene Ontology BP GO:1901863 2.74165904895888e-07 4.94072019938252e-07 1700 1300.72727272727 1463 2.4924176278426e-08 278 2.41786031942588 2.81675513838243 1 16.3425213247428 1700 278 1115 309 2539 836 652 1859 1463 1516 2041 1161 M14484 GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. 254/307 Gene Ontology BP GO:0051494 1.25501862704999e-07 2.92126146656509e-07 1465 1594.81818181818 1464 1.14092608967652e-08 798 1.91551009823612 2.0374942110463 1 13.3953900278237 1628 1401 1464 1462 1938 1406 2064 2188 1283 798 1911 1162 M15087 GO_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. 201/329 Gene Ontology BP GO:0016042 1.6737469185909e-08 1.97691467186943e-07 515 1287.54545454545 1464 1.52158811938606e-09 55 1.86440536561168 -1.7491222785227 -1 13.3762123619814 513 1464 1879 2244 55 479 1488 791 2292 2011 947 1163 M15546 GO_ACTIN_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 193/243 Gene Ontology BP GO:0007015 1.52490609027289e-08 1.97691467186943e-07 4120 2429.54545454545 1465 1.38627827349328e-09 37 2.02938236362323 2.23892473921624 1 14.5698507827178 4119 1465 1134 897 37 4508 4528 4310 601 681 4445 1164 M15202 GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. 40/58 Gene Ontology BP GO:1901862 8.62095895216975e-08 2.44742660185759e-07 2285 1602 1466 7.83723571817472e-09 494 2.39581298475964 3.0047226579373 1 16.9812978320052 2282 494 1231 1238 1567 1325 1757 2956 2656 1466 650 1165 M11316 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. 13/16 Gene Ontology BP GO:0055022 1.00967812055886e-07 2.59416471284394e-07 1480 1492.45454545455 1467 9.17889242634086e-09 831 2.75158493153964 3.60564267208098 1 19.4446759580439 1479 980 1226 831 1743 1467 2288 1517 1299 2266 1321 1166 M13687 GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 490/679 Gene Ontology BP GO:0009991 4.48059528242186e-12 1.28692653389561e-10 1995 1403.09090909091 1468 4.07326843857361e-13 115 2.40528569135045 2.72963932015859 1 25.5611164695837 1991 1280 115 1468 686 959 2281 2182 2147 481 1844 1167 M16411 GO_NEGATIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_GROWTH.html Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 13/16 Gene Ontology BP GO:0061117 1.00967812055886e-07 2.59416471284394e-07 1480 1498.90909090909 1468 9.17889242634086e-09 832 2.75158493153964 3.60564267208098 1 19.4446759580439 1480 981 1227 832 1744 1468 2289 1568 1300 2277 1322 1168 M13101 GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPASE_ACTIVITY.html Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid. 15/19 Gene Ontology BP GO:0060192 5.58040604142507e-08 2.05617623085131e-07 2430 1395.09090909091 1469 5.07309652997706e-09 152 2.703727375525 2.14820579800459 1 19.3990425165425 2426 909 1469 184 1137 1600 545 2229 152 1735 2960 1169 M14370 GO_RESPONSE_TO_CORTICOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CORTICOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. 26/34 Gene Ontology BP GO:0051412 3.54493958421279e-07 6.04197944518026e-07 640 1661.36363636364 1471 3.22267286856533e-08 470 2.75128532420962 2.88631650343149 1 18.3522834379481 640 2790 1471 2379 2693 893 470 965 2679 2462 833 1170 M16870 GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. 206/365 Gene Ontology BP GO:0010466 1.63366183166708e-11 4.19968425566128e-10 775 1463.45454545455 1472 1.48514711970837e-12 131 2.70291494353789 2.89893662981189 1 27.2396441460537 771 2161 131 1297 173 1472 1610 2345 3032 700 2406 1171 M10831 GO_CGMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CGMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate. 14/28 Gene Ontology BP GO:0046068 7.79486066158349e-08 2.32496709348385e-07 515 1532.90909090909 1473 7.08623721614971e-09 68 2.73759622751442 2.61906436335169 1 19.4858240404155 514 2032 1600 3605 1473 498 68 1292 3688 1527 565 1172 M10042 GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_TRANSMEMBRANE_IMPORT_INTO_CYTOSOL.html A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore. 39/78 Gene Ontology BP GO:0097553 2.11977549264697e-08 1.97691467186943e-07 1610 1253.45454545455 1475 1.92706864824703e-09 148 2.44999176200829 3.02763157104594 1 17.6130358575247 1610 442 782 154 148 1915 2062 1580 2821 799 1475 1173 M12167 GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 135/200 Gene Ontology BP GO:0002221 5.95638670227608e-07 9.09884022511181e-07 705 1675.81818181818 1475 5.41489846812519e-08 701 2.17344784487101 -2.40478973398053 -1 14.0570268596809 701 2201 1173 1746 3003 1332 2066 1241 1475 2106 1390 1174 M13980 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 142/177 Gene Ontology BP GO:1903844 3.33902005667726e-08 1.97691467186943e-07 1605 1533.09090909091 1475 3.035472824868e-09 535 2.2868963891491 2.67264987203634 1 16.4330113351036 1601 3333 1040 784 535 1171 1930 1475 2263 2060 672 1175 M15855 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. 68/82 Gene Ontology BP GO:0032233 7.67057338513971e-08 2.30265664264871e-07 1475 1491.36363636364 1475 6.97324877507618e-09 247 2.18209213338697 2.45228403429612 1 15.5187365810004 1475 247 1588 1036 1459 1488 3086 2025 1001 2532 468 1176 M16893 GO_EMBRYO_IMPLANTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYO_IMPLANTATION.html Attachment of the blastocyst to the uterine lining. 36/60 Gene Ontology BP GO:0007566 1.30568442839705e-07 2.99573453911809e-07 1895 1589.63636363636 1475 1.1869859144441e-08 522 2.54050255860744 2.43265014103455 1 17.7729624571383 1892 2325 924 1475 1969 1093 1460 2186 522 1059 2581 1177 M10339 GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEOLYSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 294/477 Gene Ontology BP GO:0045861 2.38804202623463e-08 1.97691467186943e-07 1495 1509.81818181818 1476 2.170947320142e-09 222 2.39896612769121 2.60795137187696 1 17.2438561640074 1495 1378 269 1476 222 1227 1754 2325 2900 973 2589 1178 M10502 GO_FOCAL_ADHESION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOCAL_ADHESION_ASSEMBLY.html The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. 38/40 Gene Ontology BP GO:0048041 2.71061473115831e-08 1.97691467186943e-07 1480 1491.18181818182 1476 2.46419524050521e-09 326 2.04808304817178 2.50291581577702 1 14.7051536179024 1476 521 1843 2514 326 1873 2536 878 1246 1759 1431 1179 M16537 GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. 200/257 Gene Ontology BP GO:0014074 1.43607555227214e-08 1.97691467186943e-07 1795 1461.54545454545 1476 1.30552323786026e-09 28 2.42131909215042 2.39585134328979 1 17.4055839049498 1793 1472 293 550 28 1476 2189 3602 1541 373 2760 1180 M16606 GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_IMPORT_INTO_CYTOSOL.html The directed movement of calcium ion into a cytosol. 39/78 Gene Ontology BP GO:1902656 2.11977549264697e-08 1.97691467186943e-07 1615 1253.54545454545 1476 1.92706864824703e-09 149 2.44999176200829 3.02763157104594 1 17.6130358575247 1611 443 783 155 149 1916 2063 1570 2822 801 1476 1181 M14304 GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SUBSTRATE_ADHERENS_JUNCTION_ASSEMBLY.html The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction. 38/40 Gene Ontology BP GO:0007045 2.71061473115831e-08 1.97691467186943e-07 1480 1523.90909090909 1477 2.46419524050521e-09 327 2.04808304817178 2.50291581577702 1 14.7051536179024 1477 522 1844 2515 327 1874 2537 1224 1247 1764 1432 1182 M15323 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis. 12/25 Gene Ontology BP GO:0002689 7.51904082737968e-07 1.10540590741857e-06 2495 1927.18181818182 1477 6.83549399745268e-08 767 3.62578291864787 3.70552579529502 1 23.1949534119755 2493 1019 767 1477 3134 2846 3517 1396 1079 1116 2355 1183 M16391 GO_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSPORT.html The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 94/164 Gene Ontology BP GO:0006814 2.75177343411553e-10 5.71607222720516e-09 3090 1674.45454545455 1478 2.5016122131452e-11 81 2.80812360661586 -2.67683533235347 -1 24.8679689140531 3087 81 165 1455 1829 2729 3907 1182 1478 188 2318 1184 M12513 GO_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 18/33 Gene Ontology BP GO:0042417 2.92191712906949e-07 5.19712553576466e-07 900 1848 1479 2.65628865194752e-08 169 2.87256561409054 3.11191695636594 1 19.3690622100292 898 4232 1479 4095 2575 705 169 986 2743 1886 560 1185 M11723 GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_LEVELS.html Any process that modulates levels of neurotransmitter. 184/285 Gene Ontology BP GO:0001505 4.3304624652615e-08 1.97691467186943e-07 3225 1765.54545454545 1480 3.93678413681999e-09 389 2.31672528602715 -2.23170706567068 -1 16.6488287993015 3221 1480 389 438 829 1979 2990 3925 1012 444 2714 1186 M11956 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_PROCESS.html Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. 370/470 Gene Ontology BP GO:0032970 2.44200638417809e-08 1.97691467186943e-07 1810 1375.54545454545 1480 2.22000582844039e-09 244 2.19574165782421 2.60104827261591 1 15.7734903664067 1809 1316 304 898 244 2078 2847 1480 1758 247 2150 1187 M13900 GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH.html Any process that activates, maintains or increases the rate of developmental growth. 195/260 Gene Ontology BP GO:0048639 4.75819264508627e-08 1.98252330758246e-07 3160 2026.90909090909 1482 4.32562977090651e-09 422 2.44500861923739 2.56075614925963 1 17.5737352846079 3160 1482 422 523 965 2817 3152 4141 750 566 4318 1188 M16158 GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. 98/126 Gene Ontology BP GO:0046467 4.43092115090843e-08 1.97691467186943e-07 1930 1540.63636363636 1482 4.02811021831786e-09 97 1.75698022924358 -1.64349680779914 -1 12.5989720698964 1926 97 2645 1482 861 976 1283 1958 1224 2471 2024 1189 M13005 GO_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 188/299 Gene Ontology BP GO:0051924 1.7681528235355e-08 1.97691467186943e-07 2780 1685 1483 1.60741167067841e-09 169 2.44376534177577 2.58146534969394 1 17.5679865809421 2779 1483 230 455 1068 1809 2872 4415 942 169 2313 1190 M15849 GO_DORSAL_SPINAL_CORD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_SPINAL_CORD_DEVELOPMENT.html The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. 7/28 Gene Ontology BP GO:0021516 7.17317819386111e-08 2.23855118283271e-07 2995 1794.09090909091 1483 7.17317842540629e-09 5 3.10047890075435 2.69322906209086 1 22.1388066240415 2993 1099 4576 81 1483 2806 1494 1395 5 1218 2585 1191 M10604 GO_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIVISION.html The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. 528/718 Gene Ontology BP GO:0051301 1.07793090565484e-07 2.67928018376708e-07 285 1632.54545454545 1484 1.07793095794192e-08 283 1.69280676966229 1.84411999056429 1 11.893455488695 283 1265 4251 3027 1884 510 489 1484 1714 1459 1592 1192 M11178 GO_REGULATION_OF_HORMONE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_LEVELS.html Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. 429/704 Gene Ontology BP GO:0010817 7.02706856090067e-13 2.40418750101991e-11 3845 2093 1484 6.38824414627535e-14 95 2.45966163589449 2.52155491103816 1 28.0755919537277 3841 1300 95 678 272 3348 3480 3910 1484 140 4475 1193 M10533 GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. 41/84 Gene Ontology BP GO:0090207 3.56845716646785e-08 1.97691467186943e-07 890 1389.54545454545 1486 3.24405202213559e-09 512 2.10269877428877 -1.98973934020376 -1 15.100308274948 887 512 2235 2736 607 832 1486 1507 1789 1848 846 1194 M11058 GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a type 2 immune response. 17/45 Gene Ontology BP GO:0002828 3.28615403187959e-07 5.68283931846269e-07 1220 1590.72727272727 1486 2.98741320248601e-08 660 2.4606492496085 -2.71160633872641 -1 16.4723417803037 660 1986 1625 1218 2648 1421 2194 1218 917 2125 1486 1195 M15362 GO_NUCLEOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOPHAGY.html A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. 18/20 Gene Ontology BP GO:0044804 1.85822619836213e-06 2.40042379260938e-06 1135 2182.09090909091 1488 1.68929797082866e-07 220 1.16551433091059 -1.37919833525416 -1 6.9557119828351 1133 2871 3672 3738 3570 1131 695 1488 1319 4166 220 1196 M15379 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. 95/148 Gene Ontology BP GO:1903426 7.94041763223514e-08 2.34880885205277e-07 2850 1769.27272727273 1488 7.21856174438831e-09 107 2.01476038460305 -2.17215319135506 -1 14.3012836150995 2846 107 1239 307 1488 3148 4271 1386 2454 666 1550 1197 M14824 GO_HEART_TRABECULA_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_TRABECULA_FORMATION.html The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. 18/21 Gene Ontology BP GO:0060347 3.87697101440415e-06 4.68253362489379e-06 585 1677.36363636364 1489 3.52452531513655e-07 195 2.53869668141056 2.93805319183322 1 14.4889392547107 581 3496 1532 3059 4299 624 210 195 2657 1489 309 1198 M13002 GO_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. 264/391 Gene Ontology BP GO:0046883 5.0871175975678e-08 2.02998167617902e-07 2200 1600.09090909091 1490 4.62465246836231e-09 158 2.41442499087706 2.48413157596743 1 17.3257270893338 2196 1403 401 158 1025 1671 1952 3953 1490 383 2969 1199 M15213 GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that activates or increases the rate or extent of osteoblast proliferation. 18/22 Gene Ontology BP GO:0033690 4.30262773506772e-07 6.99759764112902e-07 2325 1658.63636363636 1490 3.91148052413638e-08 315 3.08850075028923 2.97309425499189 1 20.4029629584974 2321 902 1496 315 2823 1354 1370 3261 782 1490 2131 1200 M16852 GO_ORGANELLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FUSION.html The creation of a single organelle from two or more organelles. 120/149 Gene Ontology BP GO:0048284 7.96336972396976e-08 2.35111417040808e-07 950 2134.45454545455 1490 7.23942728383721e-09 205 1.69863492500872 -1.42620550245208 -1 12.0388177950824 949 3341 3600 2890 1490 205 626 3527 1477 3936 1438 1201 M11684 GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html A process in which a protein is transported to, or maintained in, the cell periphery. 183/212 Gene Ontology BP GO:1990778 4.42197119949351e-08 1.97691467186943e-07 4360 2416.72727272727 1491 4.01997389852231e-09 501 2.06421086008953 -1.7139598526507 -1 14.8218412542364 4359 1491 1224 501 859 3913 4585 3960 1279 1198 3215 1202 M12981 GO_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_SEGREGATION.html The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. 190/204 Gene Ontology BP GO:0000819 4.94722737252488e-07 7.83507452837246e-07 955 1616.54545454545 1492 4.49748044093446e-08 3 1.60123751318603 1.70774713698272 1 10.4386425983533 3 2999 3401 2724 2903 288 127 954 1939 1492 952 1203 M13267 GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATECHOLAMINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. 14/21 Gene Ontology BP GO:0033605 7.9823496469124e-08 2.35373085596219e-07 2730 1684.72727272727 1492 7.25668176049023e-09 426 2.14098099945581 -1.76412544247266 -1 15.2022144653265 2726 925 1570 1164 1492 2429 2558 426 728 1143 3371 1204 M12534 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/43 Gene Ontology BP GO:0043267 9.23478072859821e-08 2.50183514628907e-07 3995 1944.72727272727 1494 8.39525556021811e-09 269 2.99360269165964 -2.95360238581524 -1 21.2157438680235 3995 761 1106 269 1649 3737 4005 1030 1494 914 2432 1205 M15003 GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 68/87 Gene Ontology BP GO:0030148 7.99435567475789e-08 2.35428714902838e-07 4175 2005 1494 7.26759633205150e-09 209 2.02295555172171 -2.01695793268915 -1 14.3577061300565 4174 209 1371 702 1494 2948 3162 3397 902 965 2731 1206 M12022 GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_VISCEROCRANIUM_MORPHOGENESIS.html The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. 8/15 Gene Ontology BP GO:0048703 4.90298869133293e-07 7.78152602102932e-07 1060 1937.18181818182 1495 4.90298977310167e-08 72 2.58119016223213 3.01742073963117 1 16.9045734348357 1060 3279 4339 1721 4526 1495 902 72 252 2808 855 1207 M16726 GO_PHAGOCYTOSIS_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_RECOGNITION.html The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. 14/130 Gene Ontology BP GO:0006910 3.9725497529954e-08 1.97691467186943e-07 2610 1776.72727272727 1495 3.61140893157082e-09 729 2.54692510771001 2.54423886930916 1 18.3143661464417 2610 985 1333 3272 729 2549 998 1495 2591 850 2132 1208 M15496 GO_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION.html The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. 42/98 Gene Ontology BP GO:0001708 1.24466969907646e-07 2.90828794356699e-07 2300 1433.90909090909 1496 1.13151797226797e-08 464 2.62318373056588 3.20907457850966 1 18.3914916374772 2296 464 882 1400 1928 1645 1979 1903 742 1038 1496 1209 M11445 GO_HIPPO_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_HIPPO_SIGNALING.html The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. 37/37 Gene Ontology BP GO:0035329 1.92263222263785e-08 1.97691467186943e-07 1390 1612.63636363636 1497 1.74784749040017e-09 107 2.21042157906894 2.13878611619311 1 15.879702251835 1390 1821 2413 1319 107 1848 1497 2671 185 3374 1114 1210 M12566 GO_EMBRYONIC_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_FORELIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 29/50 Gene Ontology BP GO:0035115 2.0397831131571e-07 4.02485065084046e-07 1420 1613.90909090909 1497 1.85434845661867e-08 457 2.83635412227568 2.74966880468195 1 19.4632918876658 1418 2367 1056 1870 2317 1282 909 2868 1712 1497 457 1211 M12780 GO_REGULATION_OF_SPINDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_ORGANIZATION.html Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. 25/33 Gene Ontology BP GO:0090224 2.6029376803896e-08 1.97691467186943e-07 1500 1792.72727272727 1497 2.36630701016941e-09 288 1.2817332240809 -0.982505053721316 -1 9.16047402750666 1497 769 3355 3391 288 1272 1139 1702 3692 2282 333 1212 M14156 GO_DRUG_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_METABOLIC_PROCESS.html The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice. 28/89 Gene Ontology BP GO:0017144 7.0422420206081e-08 2.22531460149132e-07 960 1667.45454545455 1497 6.4020384054833e-09 843 3.3375457545836 -3.28032074120419 -1 23.8494949474727 958 2764 843 2252 1377 1162 1046 2401 2365 1677 1497 1213 M14398 GO_CELLULAR_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving lipids, as carried out by individual cells. 802/1131 Gene Ontology BP GO:0044255 2.18878429055286e-08 1.97691467186943e-07 1415 1782.72727272727 1498 2.18878431211135e-09 233 1.88734003415639 -1.77290011351256 -1 13.5421488371978 1413 1209 4491 3263 233 531 1796 1423 2212 1498 1541 1214 M16813 GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS.html The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. 228/356 Gene Ontology BP GO:0045137 4.4548744905167e-08 1.97691467186943e-07 1500 2004.36363636364 1498 4.04988598247761e-09 815 2.32871459495761 2.28583742423896 1 16.7355736179729 1498 3598 815 3042 875 1080 832 4179 1953 1484 2692 1215 M10205 GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 18/30 Gene Ontology BP GO:0035588 6.4018849671624e-07 9.64981434208294e-07 1140 1561.81818181818 1499 5.81989711825292e-08 676 3.44500436424417 3.57405361981218 1 22.2522031230286 1140 1968 745 1499 3048 1302 828 1998 2442 676 1534 1216 M11169 GO_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANION_TRANSMEMBRANE_TRANSPORT.html A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 172/301 Gene Ontology BP GO:0098656 2.69758402683318e-10 5.62863608827569e-09 4590 2098.45454545455 1499 2.45234911560358e-11 24 2.38513878447814 -2.41376478990655 -1 21.1223286087496 4589 1499 229 24 879 3807 3793 3281 1292 105 3585 1217 M13775 GO_VOCALIZATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VOCALIZATION_BEHAVIOR.html The behavior in which an organism produces sounds by a mechanism involving its respiratory system. 19/36 Gene Ontology BP GO:0071625 8.02657431255837e-08 2.35520479581606e-07 4020 1919.81818181818 1499 7.29688600491214e-09 299 3.46314591330328 3.20755927339795 1 24.6591843394032 4017 753 358 418 1499 3644 3315 2752 299 333 3730 1218 M12689 GO_RESPONSE_TO_INACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. 13/23 Gene Ontology BP GO:0014854 1.15443284141446e-07 2.79769583911536e-07 2585 1542.45454545455 1500 1.04948445635675e-08 166 2.82102309437909 3.43196672811304 1 19.838360211344 2583 993 1500 1185 1857 2526 3249 324 166 2270 314 1219 M13446 GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. 194/275 Gene Ontology BP GO:2000377 3.80034885007351e-08 1.97691467186943e-07 4040 2253 1500 3.45486265065629e-09 637 2.20282404164529 -2.14361351505731 -1 15.8247326943744 4037 1500 705 843 672 3915 4549 4111 2487 637 1327 1220 M16768 GO_MULTI_ORGANISM_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_BEHAVIOR.html Any process in which an organism has a behavioral effect on another organism of the same or different species. 67/106 Gene Ontology BP GO:0051705 8.03629330577159e-08 2.35520479581606e-07 4080 2432.18181818182 1500 7.3057214539329e-09 225 2.20412065244456 2.24338594439621 1 15.6532314820234 4077 225 1120 972 1500 4348 4617 4548 1170 1206 2971 1221 M13050 GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. 79/104 Gene Ontology BP GO:0010517 8.03675716702644e-08 2.35520479581606e-07 4335 1759 1501 7.30614314601357e-09 177 3.09542053704556 -3.20515851871509 -1 22.0288023240491 4335 177 372 798 1501 3635 3114 583 1917 740 2177 1222 M12145 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_CYTOTOXICITY.html Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. 26/48 Gene Ontology BP GO:0001916 6.73187902320071e-07 1.00913122084255e-06 135 1746 1504 6.11989189374505e-08 134 1.26301567937457 -1.23706656026426 -1 8.06003902673393 134 672 2997 2833 3068 300 225 1504 4393 2047 1033 1223 M13918 GO_RETINOIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. 16/33 Gene Ontology BP GO:0042573 1.77763724730737e-07 3.6712588156774e-07 1365 1548.81818181818 1505 1.6160339917668e-08 567 3.26783100433405 3.2969962451866 1 22.5821658560548 1362 2014 1135 2263 2209 1337 567 1783 1531 1505 1331 1224 M14083 GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_MEMBRANE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of plasma membrane organization. 113/137 Gene Ontology BP GO:1903729 1.8959441848545e-08 1.97691467186943e-07 3680 1811.09090909091 1505 1.72358563744873e-09 58 2.1468760861928 -1.96301820021695 -1 15.4199391171204 3678 58 1450 230 102 3700 3777 1505 868 1537 3017 1225 M11095 GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SHORT_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. 14/24 Gene Ontology BP GO:0048172 8.06932520459354e-08 2.35993527196567e-07 2420 1880.72727272727 1506 7.33575045506028e-09 975 2.8808010263291 -2.20976476130276 -1 20.4908949463037 2418 975 1235 2246 1506 2085 2621 4113 1192 1138 1159 1226 M14283 GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives. 16/40 Gene Ontology BP GO:0042537 6.50945548554264e-08 2.16810997668074e-07 3520 2219.72727272727 1506 5.91768698013387e-09 127 3.31085267203919 3.18196224342742 1 23.6982595171808 3519 918 1084 1117 1293 3541 2697 4508 127 1506 4107 1227 M10461 GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTFLOW_TRACT_SEPTUM_MORPHOGENESIS.html The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. 15/23 Gene Ontology BP GO:0003148 2.09885929276635e-07 4.10371103569752e-07 3065 1647.54545454545 1507 1.90805408454837e-08 193 2.59447743432697 2.74725323135791 1 17.7702738236821 3065 947 1507 823 2336 2484 1256 2598 1184 1730 193 1228 M16136 GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_TRANSPORT.html The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 44/55 Gene Ontology BP GO:1901264 4.83036798490055e-08 1.990761933901e-07 1185 1873.09090909091 1507 4.39124371905196e-09 461 1.52780055067368 -1.54409724443648 -1 10.9358173120619 1181 461 2817 4087 982 1507 1804 510 3260 1405 2590 1229 M11973 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. 118/218 Gene Ontology BP GO:0070665 9.40299754934213e-08 2.51115998606105e-07 1510 1665.09090909091 1508 8.5481799556679e-09 39 2.05733919270241 -1.84478589400796 -1 14.5414596973075 1508 39 961 1886 1675 951 2131 3645 3703 604 1213 1230 M13423 GO_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. 1529/2245 Gene Ontology BP GO:0045595 8.89648326383497e-23 1.47840487952229e-20 1670 1541.72727272727 1509 8.89648326383501e-24 7 2.27467685396329 2.48964274008342 1 48.5681334000155 1666 1141 4428 7 546 1509 2163 1372 1777 14 2336 1231 M15600 GO_LOCALIZATION_WITHIN_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCALIZATION_WITHIN_MEMBRANE.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. 164/194 Gene Ontology BP GO:0051668 1.49990381748545e-08 1.97691467186943e-07 2210 1758.09090909091 1510 1.36354893428309e-09 34 2.29782477120691 2.96373656376731 1 16.5120801559569 2206 1510 646 542 34 3409 3862 2421 459 1458 2792 1232 M12268 GO_HYALURONAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 37/45 Gene Ontology BP GO:0030212 5.66383002784067e-07 8.7496019653196e-07 1515 1627.45454545455 1512 5.14893771452383e-08 551 2.36690357876871 2.26724768433684 1 15.361710666127 1512 1790 1303 715 2973 1555 1276 2783 551 1173 2271 1233 M13839 GO_SIGNAL_RELEASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_RELEASE.html The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. 163/246 Gene Ontology BP GO:0023061 4.34083746208663e-08 1.97691467186943e-07 2435 1503 1513 3.94621595248732e-09 211 2.3805521907886 -2.34423576482097 -1 17.1106279999065 2433 1513 275 407 833 1720 3188 3125 937 211 1891 1234 M11098 GO_RESPONSE_TO_TYPE_I_INTERFERON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TYPE_I_INTERFERON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 76/123 Gene Ontology BP GO:0034340 1.02909394125539e-06 1.43795018278119e-06 120 1876.72727272727 1514 9.35540384213595e-08 118 1.53642435536435 -1.605709638492 -1 9.57428336782563 118 2249 3171 2790 3293 591 531 1170 3892 1514 1325 1235 M12177 GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of leukocyte differentiation. 246/409 Gene Ontology BP GO:1902105 8.16416210160191e-08 2.37283824319446e-07 1175 1968.45454545455 1518 7.42196582233873e-09 776 1.98071987433531 -2.0184049576531 -1 14.0482951172126 1173 2609 1363 2934 1518 1455 2794 2055 3634 776 1342 1236 M12958 GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_IN_MUCOSA.html Any process of the innate immune response that takes place in the mucosal tissues. 11/97 Gene Ontology BP GO:0002227 1.5824597883764e-06 2.08707069028214e-06 565 1866.18181818182 1518 1.43860084240066e-07 73 2.83695837406498 -3.17671311584172 -1 17.2789729926977 562 2943 1518 3876 3494 754 73 769 3953 1784 802 1237 M15779 GO_LYMPH_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. 22/28 Gene Ontology BP GO:0001945 4.53820586371496e-06 5.42277141342212e-06 1660 1633.09090909091 1518 4.1256502047706e-07 454 2.7562348138643 2.75422654517435 1 15.5505686202835 1656 2815 1762 1518 3868 1032 688 656 1339 2176 454 1238 M12445 GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_LENGTH.html Any process that controls the length of actin filaments in a cell. 167/207 Gene Ontology BP GO:0030832 3.11178154647994e-08 1.97691467186943e-07 3055 2024.36363636364 1520 2.82889235499491e-09 450 2.00982386694256 -1.74288963303761 -1 14.4283415216009 3053 1520 1472 954 450 2386 2593 4631 1063 1146 3000 1239 M15943 GO_REGULATION_OF_CELL_SHAPE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_SHAPE.html Any process that modulates the surface configuration of a cell. 174/204 Gene Ontology BP GO:0008360 7.16011893224254e-08 2.23824899990528e-07 1525 1633.36363636364 1521 6.50919924115975e-09 393 2.16979677194912 2.49762094418072 1 15.4595081491473 1521 1509 688 1124 1396 2375 2596 1657 2568 393 2140 1240 M10729 GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 351/467 Gene Ontology BP GO:0071496 6.2077289123285e-08 2.12948256567067e-07 1870 1610.54545454545 1522 5.64339007953787e-09 594 2.15788632852054 2.51519920944374 1 15.4244102923546 1868 1343 594 2166 1247 644 2000 1718 3227 1387 1522 1241 M12105 GO_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_OLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 432/614 Gene Ontology BP GO:0051259 3.096812784281e-08 1.97691467186943e-07 4095 2095.72727272727 1522 2.8152843889755e-09 193 2.16346340931484 -2.03269089994591 -1 15.5399514001311 4095 1291 361 446 444 3765 3783 3870 1522 193 3283 1242 M14725 GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that activates or increases the rate or extent of cell adhesion to another cell. 209/357 Gene Ontology BP GO:0022409 5.74728586254954e-08 2.07580109259326e-07 2110 1836.27272727273 1522 5.22480546608343e-09 435 2.06493308788689 -1.89075047149728 -1 14.7798265150635 2109 1457 842 1151 1170 1522 2682 3763 3184 435 1884 1243 M12450 GO_CELL_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. 239/292 Gene Ontology BP GO:0034330 5.02984967614676e-16 3.20601240316587e-14 1740 1502.54545454545 1523 4.57259061467886e-17 45 2.68093615673402 2.98791244043775 1 38.9298773090105 1738 1398 45 344 1523 2259 2629 2232 1266 137 2957 1244 M11596 GO_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BINDING.html Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor. 14/21 Gene Ontology BP GO:1900120 1.71682104091001e-08 1.97691467186943e-07 3375 1647.63636363636 1524 1.56074641300692e-09 66 2.28440723837499 2.9620712780766 1 16.4150018790291 3371 907 1089 966 66 3008 2386 1524 1649 841 2317 1245 M11600 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 49/67 Gene Ontology BP GO:0043268 8.22862847882064e-08 2.37677062514889e-07 4425 2234.09090909091 1526 7.48057162417713e-09 364 2.51184227620433 2.49469094216631 1 17.8436685452156 4423 364 814 728 1526 4622 4295 1577 1483 391 4352 1246 M16350 GO_RESPONSE_TO_WATER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. 21/31 Gene Ontology BP GO:0009415 3.68590196098255e-08 1.97691467186943e-07 1380 1457 1527 3.35082002066957e-09 219 2.26737839304153 2.88042337984243 1 16.2917951029587 1380 828 1833 1527 647 1899 1048 219 2632 2448 1566 1247 M10857 GO_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_ACTIVATION.html A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. 162/224 Gene Ontology BP GO:0030168 3.39576414294134e-08 1.97691467186943e-07 2255 1583.63636363636 1528 3.0870583594145e-09 348 2.47517393748939 2.94025020356168 1 17.7952334519425 2252 1528 348 534 545 2860 3077 2712 871 558 2135 1248 M11096 GO_ALDEHYDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDEHYDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. 16/18 Gene Ontology BP GO:0046185 1.17185782778505e-07 2.82053557561036e-07 830 1458.18181818182 1528 1.06532535473231e-08 411 2.41506309569653 -2.77474649958225 -1 16.9580374601467 829 922 1702 1715 1872 1065 961 2175 411 2860 1528 1249 M14103 GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 23/30 Gene Ontology BP GO:0018146 2.23711189347549e-08 1.97691467186943e-07 2105 1507.36363636364 1528 2.03373810565817e-09 182 2.72977705137611 2.96892629240021 1 19.6373330321096 2103 754 681 1829 182 2664 1907 1528 1138 628 3167 1250 M13824 GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. 23/40 Gene Ontology BP GO:0046885 4.49027614947484e-08 1.97691467186943e-07 1740 1446.45454545455 1529 4.08206931011175e-09 675 3.6395061785508 3.09501441277982 1 26.2193878139684 1740 1921 675 967 892 2438 1529 763 2218 1612 1156 1251 M12815 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION.html Any process that stops or decreases the rate or extent of glial cell proliferation. 14/16 Gene Ontology BP GO:0060253 1.21108894716631e-07 2.87033193211408e-07 2150 1384.18181818182 1531 1.10099001257832e-08 225 2.41862997825633 -2.0337090285827 -1 16.9634109565598 2147 932 1575 657 1904 2322 2615 1027 291 1531 225 1252 M13800 GO_MAINTENANCE_OF_CELL_NUMBER http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_NUMBER.html Any process by which the numbers of cells of a particular type in a tissue are maintained. 162/209 Gene Ontology BP GO:0098727 5.38549114718583e-08 2.05230878852217e-07 1995 1653.63636363636 1531 4.89590116274545e-09 659 2.21103106848933 2.47765874428636 1 15.8453246282393 1994 1549 1531 659 1097 1368 1230 3038 895 2633 2196 1253 M14413 GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_PLASMA_MEMBRANE.html The process of directing proteins towards the plasma membrane; usually uses signals contained within the protein. 34/36 Gene Ontology BP GO:0072661 4.64776397187352e-08 1.97800744927456e-07 2455 1694.18181818182 1531 4.22524006369373e-09 551 2.32805139061468 -1.31679565619218 -1 16.7301722174493 2454 551 1294 1693 939 1531 1522 4172 766 1584 2130 1254 M12714 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. 142/177 Gene Ontology BP GO:0017015 3.33902005667726e-08 1.97691467186943e-07 1600 1537.36363636364 1532 3.035472824868e-09 534 2.2868963891491 2.67264987203634 1 16.4330113351036 1600 3332 1039 783 534 1170 1929 1532 2262 2059 671 1255 M12474 GO_REGULATION_OF_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_PLASTICITY.html A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. 166/229 Gene Ontology BP GO:0048167 2.7568298628222e-08 1.97691467186943e-07 2195 1516.81818181818 1534 2.50620899760742e-09 248 2.38664550297677 2.83630405038389 1 17.1547142157123 2193 1534 590 248 341 1662 2119 3279 958 1097 2664 1256 M14576 GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of adherens junction organization. 42/47 Gene Ontology BP GO:1903393 4.01741575546133e-07 6.67793881520189e-07 775 1590.63636363636 1534 3.65219680825549e-08 444 2.67041590092157 3.11504922886966 1 17.684263706938 775 444 554 1035 2763 1626 1534 2967 2391 1037 2371 1257 M15477 GO_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of organelle assembly. 168/202 Gene Ontology BP GO:1902115 8.37940590137725e-08 2.40389942771476e-07 1545 1752 1535 7.61764201866712e-09 849 1.66294799043471 -1.51498557250392 -1 11.7662103749983 1543 1535 3375 1414 1545 1002 1381 1586 849 3874 1168 1258 M10785 GO_LOOP_OF_HENLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOOP_OF_HENLE_DEVELOPMENT.html The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. 10/16 Gene Ontology BP GO:0072070 4.31095434412967e-07 7.00634857190575e-07 1540 1343.27272727273 1536 3.91905017170187e-08 82 3.58518177377328 3.90417218724583 1 23.70017820949 1536 1082 1298 2087 2824 1719 823 210 82 1561 1554 1259 M13516 GO_PIGMENT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. 36/41 Gene Ontology BP GO:0050931 3.79213807533538e-07 6.37687692972011e-07 1305 1665.81818181818 1536 3.44739884453278e-08 564 2.64512133894368 -2.27931032750887 -1 17.5728767167884 2851 564 1394 760 2732 2120 2010 1749 1304 1536 1304 1260 M10732 GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS.html The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. 29/43 Gene Ontology BP GO:0060441 7.63470068081839e-06 8.88106556696199e-06 1470 1831.81818181818 1537 6.94066106890005e-07 202 2.82591377786271 3.30177434653172 1 15.293149852129 1469 1867 1373 1177 3973 1537 1217 2413 202 2849 2073 1261 M14794 GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_NEURONAL_SYNAPTIC_PLASTICITY.html A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. 38/54 Gene Ontology BP GO:0048169 5.14504299156745e-08 2.03397493965704e-07 1540 1543 1537 4.67731191990209e-09 540 2.05448674431567 2.25050005566104 1 14.724085259736 1537 540 1775 861 1040 1231 979 2824 2767 1765 1654 1262 M12554 GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. 18/26 Gene Ontology BP GO:0051447 8.28987175353757e-08 2.38545289234449e-07 585 1556.27272727273 1538 7.53624733264566e-09 83 1.73960545924823 1.68289879334853 1 12.3200956758336 585 1979 2425 3327 1538 338 83 718 3322 2319 485 1263 M16808 GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_A_ACTIVITY.html Any process that initiates the activity of the inactive enzyme protein kinase A. 13/16 Gene Ontology BP GO:0034199 3.2108701618245e-06 3.93473238424267e-06 900 1667 1540 2.91897713459594e-07 178 2.13210252502776 2.27485580211407 1 12.3241762915193 900 2515 2218 1540 3769 986 238 729 2023 3241 178 1264 M10683 GO_AMIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_TRANSPORT.html The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 85/124 Gene Ontology BP GO:0042886 1.76546665296496e-08 1.97691467186943e-07 2330 1247.18181818182 1541 1.60496969739324e-09 74 2.6794192148659 -2.44563085162404 -1 19.2729849765125 2328 141 457 1458 74 1610 2465 1541 1683 376 1586 1265 M12956 GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of muscle cell differentiation. 178/264 Gene Ontology BP GO:0051147 5.09291313299093e-08 2.02998167617902e-07 3115 1907 1542 4.6299211371726e-09 853 2.26025165645504 2.53855945523687 1 16.2121692966999 3111 1519 866 1542 1026 2477 2790 1870 1504 853 3419 1266 M13200 GO_REGULATION_OF_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of B cell differentiation. 27/36 Gene Ontology BP GO:0045577 8.4160744425887e-08 2.41132970328604e-07 965 1464.54545454545 1542 7.65097705867696e-09 418 1.97171034164473 -1.94590477310129 -1 13.9690094171759 961 689 2034 1948 1548 1232 1864 1346 2528 1542 418 1267 M15753 GO_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. 425/611 Gene Ontology BP GO:0048732 1.4867443805639e-09 2.71287121677013e-08 1875 1465.18181818182 1542 1.35158580142603e-10 164 2.36576942870951 2.56247058886387 1 19.2059681117752 1873 1305 190 164 542 1664 2004 3926 1542 295 2612 1268 M11876 GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 24/42 Gene Ontology BP GO:0060079 8.23261921950362e-08 2.37677062514889e-07 2535 1916.54545454545 1543 7.48419957052403e-09 187 2.38515251622169 3.18297810968881 1 16.9379833336565 2533 751 1543 1010 1528 2701 3434 3267 187 1420 2708 1269 M11157 GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. 160/206 Gene Ontology BP GO:1901136 4.20351824127929e-08 1.97691467186943e-07 3070 2159.81818181818 1546 3.82138029235954e-09 682 2.23039490093161 2.88770566529838 1 16.0242128481748 3069 1546 979 2473 791 4437 4405 1363 1092 682 2921 1270 M10677 GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of dendritic cell differentiation. 26/50 Gene Ontology BP GO:2001198 9.3056953678991e-07 1.32576241723315e-06 155 1656.63636363636 1548 8.45972664007428e-08 152 1.56558812856761 -1.47474870537631 -1 9.81777230675043 152 674 2341 1905 3235 579 508 1514 3311 2456 1548 1271 M11529 GO_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 32/54 Gene Ontology BP GO:0006584 4.45463603555954e-08 1.97691467186943e-07 1515 1768.72727272727 1548 4.04966920523506e-09 164 2.39766510907758 2.93491419786163 1 17.2344430590168 1515 3698 1820 3099 870 1548 1291 433 2793 2225 164 1272 M15740 GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. 32/54 Gene Ontology BP GO:0009712 4.45463603555954e-08 1.97691467186943e-07 1520 1776.63636363636 1549 4.04966920523506e-09 165 2.39766510907758 2.93491419786163 1 17.2344430590168 1516 3699 1821 3100 871 1549 1292 509 2794 2227 165 1273 M16810 GO_AMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving AMP, adenosine monophosphate. 16/18 Gene Ontology BP GO:0046033 4.69700581249891e-06 5.59241761657048e-06 1280 1775.63636363636 1550 4.27001440058973e-07 211 1.87585436493366 2.12950156001257 1 10.5202875766061 1280 2005 2595 2108 4025 1550 1380 211 501 2413 1464 1274 M10910 GO_NECROTIC_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROTIC_CELL_DEATH.html A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. 41/55 Gene Ontology BP GO:0070265 2.91052836924946e-07 5.17884837557084e-07 1090 1627.45454545455 1551 2.64593523118451e-08 501 1.93168857883915 -1.92525044372235 -1 12.9910862985805 1090 501 2071 1955 2574 1328 1516 2316 884 2116 1551 1275 M15951 GO_ORGANELLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_LOCALIZATION.html Any process in which an organelle is transported to, and/or maintained in, a specific location. 495/627 Gene Ontology BP GO:0051640 3.85784741283783e-08 1.97691467186943e-07 3875 2255.45454545455 1551 3.50713407317071e-09 466 1.93836610388125 -1.55073098372828 -1 13.9113316809692 3874 1258 1551 466 690 4238 3910 2923 711 1360 3829 1276 M11264 GO_CAMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 13/17 Gene Ontology BP GO:0006171 2.06429319857535e-06 2.64240887289439e-06 680 1713.81818181818 1552 1.87663194139578e-07 52 2.73221683425093 2.76076170451893 1 16.3347197252706 677 3217 1552 2727 3602 502 52 1168 3113 1751 491 1277 M16681 GO_SYNCYTIUM_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNCYTIUM_FORMATION.html The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. 31/57 Gene Ontology BP GO:0006949 2.5163826965675e-07 4.62612749392673e-07 1545 1441.54545454545 1552 2.28762089490363e-08 134 2.84954855747019 3.30815971854576 1 19.3684012187007 1544 612 704 134 2489 1906 2576 1723 1552 987 1630 1278 M12791 GO_POLYOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_TRANSPORT.html The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/22 Gene Ontology BP GO:0015791 3.27388831435704e-08 1.97691467186943e-07 4420 2167.54545454545 1553 2.97626214825162e-09 102 3.64662416043015 -3.52516567705574 -1 26.2708877003265 4417 1002 715 102 508 4451 4392 2382 481 1553 3840 1279 M14817 GO_PROTEIN_HOMOOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 238/332 Gene Ontology BP GO:0051260 2.31753234533415e-08 1.97691467186943e-07 4270 2163.81818181818 1553 2.10684760886144e-09 195 2.08384969506408 -2.03904045590115 -1 14.9639317774406 4269 1412 1013 1289 195 3863 3088 3193 1553 610 3317 1280 M15452 GO_MONOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 197/276 Gene Ontology BP GO:0005996 2.7750013167122e-08 1.97691467186943e-07 1655 1609.36363636364 1554 2.52272850155916e-09 349 1.82817454022283 -1.61723116526879 -1 13.1140757870627 1652 1473 2262 2242 349 1207 1554 2065 1467 1060 2372 1281 M12473 GO_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BUDDING.html The evagination of a membrane, resulting in formation of a vesicle. 153/170 Gene Ontology BP GO:0006900 1.11708261474674e-08 1.77740684677253e-07 1225 1956.18181818182 1555 1.01552965492627e-09 4 1.68116231418625 -1.17629357636192 -1 12.1342412769307 1222 1555 3186 2155 4 1284 1208 3729 965 3692 2518 1282 M16757 GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. 68/105 Gene Ontology BP GO:0002088 7.87005834808946e-08 2.33849999170963e-07 2430 1671.72727272727 1555 7.15459875420456e-09 461 2.05957119491038 2.67099881494895 1 14.6261237548235 2427 1696 1555 835 1478 2481 3028 2392 581 1455 461 1283 M13972 GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. 12/26 Gene Ontology BP GO:0045073 9.49908574027565e-06 1.09339903808899e-05 985 1832.54545454545 1556 8.63556977759577e-07 289 1.87624299594807 -1.95292144559478 -1 9.93288186187792 983 2045 1923 1075 4164 1214 2272 289 3998 1556 639 1284 M15366 GO_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. 146/209 Gene Ontology BP GO:0010001 5.62952403081708e-08 2.06162496199217e-07 980 1583.72727272727 1556 5.11774924988142e-09 424 2.48488561892859 2.94124128144774 1 17.8166327682842 2370 1556 424 977 1147 2152 2324 1685 1055 976 2755 1285 M14903 GO_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_SLEEP.html Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. 11/36 Gene Ontology BP GO:0030431 1.77882409229623e-07 3.6715029165863e-07 1025 1582.36363636364 1557 1.6171129419311e-08 582 2.90754469408375 3.18773601939679 1 20.0798672855278 1024 2058 1706 2765 2210 1263 582 714 1182 2345 1557 1286 M11270 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_CONTRACTION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. 41/62 Gene Ontology BP GO:0086004 1.39565221281929e-07 3.11452674737746e-07 1990 1502.09090909091 1558 1.2687748194161e-08 461 2.54812951696589 3.20174954583512 1 17.7802146173693 1989 481 908 1497 2028 1976 2241 981 2403 461 1558 1287 M10060 GO_POTASSIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_TRANSPORT.html The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 80/175 Gene Ontology BP GO:0006813 1.96567598832622e-10 4.21488035653544e-09 4455 2224.36363636364 1559 1.78697817136532e-11 21 3.0193943913758 -2.73963244903127 -1 27.178590481327 4455 119 159 21 1559 4218 3997 4198 968 245 4529 1288 M13140 GO_CHEMOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of chemicals. 16/29 Gene Ontology BP GO:0007635 2.50350250456783e-07 4.6171597062325e-07 1045 1558.90909090909 1559 2.27591162677761e-08 44 2.46495193563921 2.90334145008755 1 16.7412726039387 1041 928 1646 1559 3829 1938 2311 44 1867 1503 482 1289 M11274 GO_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_TRANSPORT.html The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 128/215 Gene Ontology BP GO:0006836 9.18929721475496e-10 1.75958024445493e-08 2970 1501.18181818182 1561 8.35390656235756e-11 163 2.51512567815058 -2.452165306869 -1 20.9359856950462 2968 1561 179 369 558 2119 3083 2860 667 163 1986 1290 M11905 GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 70/125 Gene Ontology BP GO:1903557 1.37401416169909e-07 3.09153186382295e-07 655 1640.81818181818 1562 1.24910386137583e-08 653 1.8121518023026 -1.7693458723015 -1 12.6183731337068 653 1689 1938 1562 2011 1113 2416 679 3604 1238 1146 1291 M14311 GO_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PIGMENTATION.html The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. 44/53 Gene Ontology BP GO:0048066 2.33792568577636e-07 4.40955339112988e-07 2830 1544.81818181818 1562 2.12538721293294e-08 226 2.42825888392048 -2.23027525243678 -1 16.5427413906893 2830 475 1562 226 2422 1921 1729 1502 1436 1907 983 1292 M12476 GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLCERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. 10/12 Gene Ontology BP GO:0006677 1.51976615119046e-05 1.71429621854284e-05 1085 2032 1563 1.38161513625369e-06 1082 1.56888744824835 -1.70753043611554 -1 7.95651344575809 1082 1085 2845 2347 4102 1563 1716 1449 1414 3205 1544 1293 M16144 GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION.html Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. 138/173 Gene Ontology BP GO:0010811 3.70626338895965e-09 6.43479236896615e-08 1445 1562.36363636364 1564 3.36933035927589e-10 198 2.60498444710328 2.87609987651723 1 20.1048532649175 1442 1564 198 1293 1312 1764 2105 3177 1610 353 2368 1294 M11430 GO_RESPONSE_TO_AXON_INJURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AXON_INJURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. 53/74 Gene Ontology BP GO:0048678 9.72969641140309e-08 2.55775578543834e-07 2105 1195.18181818182 1565 8.84517894700693e-09 90 3.11104895832324 3.380003063608 1 22.0202921559734 2104 342 530 430 1706 1759 1565 1640 90 750 2231 1295 M16678 GO_LENS_FIBER_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. 15/29 Gene Ontology BP GO:0070307 4.08180615336327e-08 1.97691467186943e-07 2200 1549.72727272727 1565 3.71073293554158e-09 12 2.96627783641291 3.7818419815479 1 21.3484589887988 2504 968 1410 253 757 2719 2200 1565 12 2200 2459 1296 M13740 GO_NEGATIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 188/307 Gene Ontology BP GO:0051048 7.49648309534111e-08 2.28689428729205e-07 4140 2162.72727272727 1566 6.81498486434836e-09 150 2.49258498314464 2.46165977466628 1 17.7510362334919 4138 1501 364 150 1431 2785 2840 4611 1566 673 3731 1297 M15390 GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 12/22 Gene Ontology BP GO:0046135 1.10782979616227e-07 2.71799508392894e-07 1295 1519.63636363636 1566 1.00711804722549e-08 27 3.05194834597644 3.77333162852998 1 21.5129030940574 1292 2034 1566 1471 2577 2293 2411 27 99 2026 920 1298 M13361 GO_CELLULAR_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. 142/197 Gene Ontology BP GO:0044242 1.22105896058503e-08 1.88745550806631e-07 2395 1502.27272727273 1567 1.11005360669295e-09 12 1.7803629953137 -1.5970265974007 -1 12.8067927528531 572 1567 2391 2253 12 944 1650 980 2419 2394 1343 1299 M14331 GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 61/118 Gene Ontology BP GO:0030816 5.36393903098413e-08 2.05087954115883e-07 1570 2164.90909090909 1567 4.87630832887749e-09 1036 2.12897405378488 2.25803495653026 1 15.2537619447736 1567 3051 1740 2849 1090 1036 1513 4368 4033 1462 1105 1300 M16383 GO_RECEPTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 19/24 Gene Ontology BP GO:0032801 5.65362873737806e-08 2.06162496199217e-07 2020 1699.18181818182 1567 5.13966262060616e-09 29 1.30335800338877 -1.34160026788462 -1 9.29130206322643 2020 841 3065 846 1154 2050 1310 1567 29 3617 2192 1301 M16656 GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. 34/39 Gene Ontology BP GO:0014065 7.68615023746285e-08 2.30287553476591e-07 3280 1965.36363636364 1568 6.98740955090384e-09 165 2.36082161131999 -2.90961937816982 -1 16.7989941910281 3278 566 1365 252 1462 4058 3451 2618 165 2836 1568 1302 M11041 GO_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_FUSION.html The membrane organization process that joins two lipid bilayers to form a single membrane. 134/181 Gene Ontology BP GO:0061025 8.66478976316588e-08 2.45384890956523e-07 780 1718.36363636364 1569 7.87708191312017e-09 170 1.85798213676754 -1.68877822192124 -1 13.1415319549909 776 2631 3313 2362 1569 170 724 1874 1032 4091 360 1303 M12404 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 465/586 Gene Ontology BP GO:0044089 3.67748007936216e-08 1.97691467186943e-07 2340 1684.90909090909 1569 3.34316376439478e-09 451 2.20430013515053 2.48082000470285 1 15.8354124978725 2338 1286 451 537 643 2510 3070 2275 1569 767 3088 1304 M10716 GO_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NECROPTOTIC_PROCESS.html A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. 33/46 Gene Ontology BP GO:0070266 6.56620531236603e-07 9.87158427090118e-07 1120 1502.18181818182 1570 5.96927933831087e-08 605 2.19731011750787 -2.19327943026737 -1 14.1286508616468 1116 605 1688 1579 3060 1436 1570 1789 658 1722 1301 1305 M15174 GO_VISUAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_VISUAL_BEHAVIOR.html The behavior of an organism in response to a visual stimulus. 51/78 Gene Ontology BP GO:0007632 8.67336498085717e-08 2.45384890956523e-07 1180 1929.09090909091 1570 7.88487756618116e-09 359 1.53524790121342 1.35020654001095 1 10.8391832517202 1180 1752 3116 2948 1570 922 1416 1415 2970 3572 359 1306 M14252 GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. 195/250 Gene Ontology BP GO:0006575 4.44974415634318e-08 1.97691467186943e-07 1680 1607.36363636364 1571 4.0452220421311e-09 866 2.10683064244283 -2.2744851074794 -1 15.130203088392 1678 1496 1402 2226 866 1524 1571 1648 1123 1729 2418 1307 M12560 GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. 303/340 Gene Ontology BP GO:0051056 1.96570276961318e-08 1.97691467186943e-07 1975 1340.72727272727 1572 1.78700253379705e-09 62 2.1782775622683 2.52280389450037 1 15.6471344762511 1975 1352 384 62 116 1985 2534 1782 1572 284 2702 1308 M11947 GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_TRANSPORT.html The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. 135/243 Gene Ontology BP GO:0015850 1.33205649362711e-10 2.92361267209761e-09 2970 1465.54545454545 1573 1.21096044882524e-11 33 2.93148208593919 -2.85244869531964 -1 26.8865792399059 2970 1573 156 33 207 2369 3119 2409 1195 380 1710 1309 M16265 GO_RESPONSE_TO_MISFOLDED_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MISFOLDED_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. 16/17 Gene Ontology BP GO:0051788 9.27146242341438e-07 1.32169468922019e-06 1225 2162.18181818182 1574 8.42860575517284e-08 439 1.25116825714305 -1.49627388644441 -1 7.8251399326088 1225 3791 3595 3201 3233 1451 1574 578 620 4077 439 1310 M16507 GO_PROTEIN_AUTOPROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPROCESSING.html Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. 10/19 Gene Ontology BP GO:0016540 9.03257072564486e-08 2.47858716290421e-07 3205 1825.90909090909 1574 8.21142826954221e-09 569 3.58068959619176 -4.98316532608759 -1 25.4142929367914 3203 1072 1198 569 1627 3707 2520 1326 985 1574 2304 1311 M15464 GO_POSITIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_KILLING.html Any process that activates or increases the frequency, rate or extent of cell killing. 43/84 Gene Ontology BP GO:0031343 1.79922572632404e-07 3.70433509052467e-07 600 1844.72727272727 1575 1.63565988497283e-08 292 1.56290244108225 -1.37874959140495 -1 10.7347742559743 599 471 2620 3365 2216 292 496 3410 4248 1575 1000 1312 M16386 GO_SIGNAL_PEPTIDE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_PEPTIDE_PROCESSING.html The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. 25/30 Gene Ontology BP GO:0006465 5.419773325622e-08 2.05617623085131e-07 1580 1691.18181818182 1577 4.92706678103631e-09 384 2.77604534743254 -2.69955782376671 -1 19.9209436591917 1577 1889 1490 1708 1103 1567 930 3373 384 1593 2989 1313 M10407 GO_RESPONSE_TO_ORGANOPHOSPHORUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANOPHOSPHORUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors. 175/232 Gene Ontology BP GO:0046683 3.25878075562924e-10 6.67978275592196e-09 2345 1686.09090909091 1578 2.96252796010178e-11 23 2.58769878622708 2.46395536264251 1 22.7181010188235 2341 1511 167 471 23 1972 2564 4063 1578 289 3568 1314 M11241 GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that activates or increases the frequency, rate or extent of viral release from host cell. 18/18 Gene Ontology BP GO:1902188 8.72933928354435e-08 2.45512816355666e-07 265 1994.27272727273 1578 7.93576329992203e-09 195 1.11626608362519 -1.11626608362519 -1 7.84994274618221 263 2862 3522 4384 1578 587 195 237 4415 3479 415 1315 M12261 GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity. 34/46 Gene Ontology BP GO:0030513 1.17572262552364e-07 2.82410554926575e-07 2160 1585.09090909091 1578 1.06883880759685e-08 270 2.3215116520834 2.38789827592845 1 16.2953825967203 2156 583 1431 270 1877 1033 1578 3864 791 1868 1985 1316 M15906 GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. 30/38 Gene Ontology BP GO:0046473 3.28137644914841e-07 5.68015052748793e-07 720 1950 1578 2.9830699441611e-08 718 1.88965491080917 -2.16349747829793 -1 12.6241051230762 718 2753 2351 3617 2647 1462 1458 1220 1352 2294 1578 1317 M13524 GO_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of T cell proliferation. 131/232 Gene Ontology BP GO:0042129 8.72998303283674e-08 2.45512816355666e-07 1625 1622.09090909091 1579 7.93634852659791e-09 587 2.01420251339338 -2.02162338358127 -1 14.2554980135374 1622 1589 1034 1510 1579 977 2224 3131 2965 587 625 1318 M16266 GO_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other 765/1247 Gene Ontology BP GO:0055085 1.86447587254416e-12 5.70750410193946e-11 2345 1819.54545454545 1579 1.86447587254572e-13 70 2.30415272263391 -2.14660644060277 -1 25.3596924508665 2345 1211 4610 1454 1199 1579 2267 1153 1730 70 2397 1319 M14080 GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 45/58 Gene Ontology BP GO:0010828 7.8924390821746e-08 2.34056845438868e-07 1580 1719 1580 7.17494487755789e-09 576 2.22597177795996 2.2906340574093 1 15.8160390252148 1580 2712 1815 3422 1484 928 576 858 2465 2003 1066 1320 M14875 GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune effector process. 147/270 Gene Ontology BP GO:0002699 2.53301916849387e-07 4.6438684755721e-07 500 1694 1582 2.30274496376249e-08 496 1.84872248392197 -1.77981104453089 -1 12.5227403693715 496 2190 1432 1582 2498 898 1861 2320 3490 528 1339 1321 M15944 GO_ARACHIDONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. 37/110 Gene Ontology BP GO:0019369 1.28687496808503e-07 2.96574008246639e-07 1585 1946 1582 1.16988640305446e-08 817 2.58975744334973 -2.7175742275437 -1 18.1319493157978 1582 2730 1129 1528 1956 942 1418 3694 3952 1658 817 1322 M13534 GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. 10/22 Gene Ontology BP GO:0021514 1.17545913492073e-05 1.3405419987221e-05 1350 1685.09090909091 1583 1.06860492312841e-06 171 3.18821470765038 3.03685103381873 1 16.6530614619147 1348 2062 1583 1786 4058 1224 171 387 2343 2081 1493 1323 M16064 GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MHC_CLASS_II_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II. 14/29 Gene Ontology BP GO:0045346 1.69174910465792e-06 2.21239701629379e-06 1590 1525.36363636364 1586 1.53795491415931e-07 221 2.00915836493422 -2.23674742655781 -1 12.1492012783698 1586 991 2544 661 3527 1776 1800 221 362 2963 348 1324 M12949 GO_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 137/175 Gene Ontology BP GO:0051591 1.16500542354075e-08 1.82517516354717e-07 3470 2039.09090909091 1587 1.05909584519092e-09 9 2.67702298437874 -2.59877277780101 -1 19.355852504918 3470 1587 294 176 9 2863 2860 4534 1521 512 4604 1325 M14994 GO_REGULATION_OF_PLATELET_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_ACTIVATION.html Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. 37/56 Gene Ontology BP GO:0010543 5.7476335718258e-07 8.85554271844551e-07 1460 1694.81818181818 1588 5.22512279402774e-08 472 3.22814182944563 3.76250740648399 1 20.9742736994419 1457 1806 472 1732 2982 1574 989 1588 3092 672 2279 1326 M13958 GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 12/18 Gene Ontology BP GO:0001574 1.61261708608615e-06 2.12263290001665e-06 1260 1786.81818181818 1589 1.46601660740747e-07 1196 2.62293180513741 2.7579616448701 1 15.9461044769546 1259 2040 1520 1841 3500 1674 1463 1196 1550 2023 1589 1327 M12642 GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport. 125/180 Gene Ontology BP GO:1903169 5.54504684020681e-08 2.05617623085131e-07 1595 1760.90909090909 1591 5.04095179997124e-09 404 2.35983393010396 2.52722401384126 1 16.9172475023757 2898 1591 465 465 1128 2116 3328 4582 802 404 1591 1328 M14090 GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SARCOPLASMIC_RETICULUM_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum. 11/18 Gene Ontology BP GO:0070296 5.70149997313756e-08 2.06451979572055e-07 3935 2132.90909090909 1591 5.18318192808830e-09 30 2.64557631141774 3.14291619797043 1 18.974359017889 3931 1036 1591 604 1165 4537 3740 2027 30 1308 3493 1329 M14856 GO_MYELIN_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_ASSEMBLY.html The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. 25/30 Gene Ontology BP GO:0032288 1.94915679970606e-07 3.90755130936334e-07 3440 1851.72727272727 1591 1.77196088399777e-08 53 2.93474668868483 -2.18337183809757 -1 20.1830768405983 3439 737 1280 167 2282 2577 3117 529 53 1591 4597 1330 M16060 GO_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTOSIS.html A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. 485/858 Gene Ontology BP GO:0006897 2.00268644983494e-08 1.97691467186943e-07 4070 2161.27272727273 1591 1.82062406187785e-09 58 2.08177001735919 -1.81593169561355 -1 14.9488849330852 4068 1270 498 58 125 2930 3895 4650 1591 723 3966 1331 M10610 GO_NEGATIVE_REGULATION_OF_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. 67/78 Gene Ontology BP GO:0051782 8.78913735843935e-08 2.4552368046601e-07 560 1511.45454545455 1592 7.990125190519e-09 314 1.83401605822853 2.00211955205306 1 12.9700746650498 560 2265 2742 2859 1592 314 347 682 2248 2223 794 1332 M12536 GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of T cell death by apoptotic process. 32/41 Gene Ontology BP GO:0070232 5.40487262737278e-07 8.40861049281179e-07 2290 1764.90909090909 1592 4.91352177747353e-08 996 2.71796272444384 -2.53336805343401 -1 17.7075751448999 2287 2352 996 1592 2954 2005 2409 1232 1368 1082 1137 1333 M15065 GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 25/32 Gene Ontology BP GO:0050995 6.44959097059954e-08 2.15972315171505e-07 3000 1860.36363636364 1592 5.86326469061623e-09 604 2.1965007060244 -2.48569277478478 -1 15.6879296785855 3000 716 1863 651 1284 3776 3688 1845 604 1592 1445 1334 M10933 GO_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. 125/161 Gene Ontology BP GO:0010469 1.80466155027609e-08 1.97691467186943e-07 2070 1644.63636363636 1593 1.64060142279977e-09 80 2.22754881916348 2.63215141029804 1 16.003620931799 2067 1593 766 1320 80 1946 2700 3537 1462 749 1871 1335 M16931 GO_PROTEIN_HETEROOLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROOLIGOMERIZATION.html The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. 122/185 Gene Ontology BP GO:0051291 8.50915884406914e-08 2.42753624165872e-07 4635 2295.90909090909 1594 7.73559924835121e-09 332 2.54309106655487 -2.13326793054339 -1 18.0418702139358 4633 1594 332 515 1558 4653 4374 2601 687 346 3962 1336 M16028 GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of embryonic development. 31/48 Gene Ontology BP GO:0040019 7.65625778463663e-08 2.30132864805648e-07 2565 1933 1595 6.96023459189399e-09 457 2.69753130034965 3.49527139806353 1 19.2119130036991 2562 2366 1595 1016 1456 3727 3880 1131 457 2091 982 1337 M16660 GO_NUCLEAR_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 220/255 Gene Ontology BP GO:0098813 6.87051413626255e-07 1.02594679961584e-06 5 1696.90909090909 1596 6.24592389263476e-08 5 1.56901605405991 1.6917712432941 1 10.0280533839964 5 3317 3537 2733 3080 221 122 1041 2127 1596 887 1338 M15138 GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. 37/55 Gene Ontology BP GO:0002053 2.02306890501967e-07 3.99886984496878e-07 1600 1485.45454545455 1597 1.83915371914219e-08 215 2.44531595670846 3.20016790105158 1 16.7717862842507 1597 571 1572 320 2313 1180 1805 3063 1784 1920 215 1339 M16052 GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Ras protein signal transduction. 215/239 Gene Ontology BP GO:0046578 1.92884789263842e-08 1.97691467186943e-07 1625 1256.54545454545 1598 1.75349809959052e-09 74 2.31314456944793 2.55316333508503 1 16.6229216671907 1625 1432 374 74 110 1783 2304 1771 1598 281 2470 1340 M15965 GO_RESPONSE_TO_GONADOTROPIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GONADOTROPIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 24/37 Gene Ontology BP GO:0034698 1.3642590281672e-07 3.07702242271545e-07 2155 1511.81818181818 1599 1.24023555706121e-08 352 2.76309326533499 2.07250168450889 1 19.3054089146331 2155 741 1284 970 2007 2168 1988 1599 352 1423 1943 1341 M13520 GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of lymphocyte differentiation. 129/229 Gene Ontology BP GO:0045619 6.90458032889321e-08 2.20804208043575e-07 715 1724.45454545455 1601 6.27689140508156e-09 714 1.86413866319465 -1.76216171830452 -1 13.2776754671858 908 1601 1697 2860 1361 714 2183 2364 3597 970 714 1342 M14525 GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_ORGAN_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. 41/57 Gene Ontology BP GO:0048635 8.86534068524311e-08 2.46335138997725e-07 2665 1697.27272727273 1602 8.05940094771797e-09 301 2.37164342325909 3.03994032132347 1 16.8016358206943 2664 480 1233 301 1602 1698 2258 3145 2873 1354 1062 1343 M11144 GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. 21/23 Gene Ontology BP GO:0061099 2.08140157026624e-07 4.07951200777119e-07 2335 1589.81818181818 1603 1.89218342471447e-08 139 1.47132243676917 -1.58468286491826 -1 10.0326015021093 946 1929 3053 2334 2331 772 139 997 1603 2839 545 1344 M13125 GO_MIDBRAIN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDBRAIN_DEVELOPMENT.html The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). 124/187 Gene Ontology BP GO:0030901 8.24698449004305e-08 2.37677062514889e-07 2135 1862.18181818182 1606 7.49725890835631e-09 690 2.26743974100487 2.81952097226259 1 16.0964731773497 2131 1606 1354 1206 1532 2976 2721 2583 690 2772 913 1345 M13401 GO_EXOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCRINE_SYSTEM_DEVELOPMENT.html Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. 61/75 Gene Ontology BP GO:0035272 3.26998499620301e-08 1.97691467186943e-07 1790 1185.63636363636 1607 2.97271367709695e-09 238 2.59039733854149 2.91824932977049 1 18.628895599523 1789 251 525 238 504 1607 1897 1687 1921 463 2160 1346 M12386 GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASOCONSTRICTION.html Any process that activates or increases the frequency, rate or extent of vasoconstriction. 23/45 Gene Ontology BP GO:0045907 4.95348387448867e-08 2.01774734543894e-07 1955 1720.63636363636 1608 4.50316726001863e-09 804 2.85716332998971 2.23535813415888 1 20.5316174733042 1952 804 993 1180 1000 2424 2212 2668 1427 1608 2659 1347 M12592 GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 21/30 Gene Ontology BP GO:0034381 7.02545819781943e-08 2.22275537837552e-07 1180 1592.09090909091 1608 6.38678038379064e-09 1043 2.61688115534822 2.77651168094602 1 18.6767474025184 1179 2424 1406 1774 1375 1787 1608 1735 1043 1283 1899 1348 M15878 GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. 62/133 Gene Ontology BP GO:0046427 9.56843273298855e-08 2.53253228137632e-07 2875 1820.09090909091 1608 8.69857559013385e-09 272 2.35861602920238 -2.35097685619009 -1 16.6781047270952 2872 292 940 272 1693 3834 4309 1608 1338 1036 1827 1349 M11523 GO_POSITIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STAT_CASCADE.html Any process that activates or increases the frequency, rate or extent of STAT cascade. 62/133 Gene Ontology BP GO:1904894 9.56843273298855e-08 2.53253228137632e-07 2875 1819.27272727273 1609 8.69857559013385e-09 271 2.35861602920238 -2.35097685619009 -1 16.6781047270952 2871 291 939 271 1692 3833 4308 1609 1337 1035 1826 1350 M10070 GO_APICAL_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APICAL_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, apical regions of the cell. 23/30 Gene Ontology BP GO:0045176 5.04991779635385e-08 2.02998167617902e-07 3255 1698.18181818182 1612 4.59083446570049e-09 193 2.48666166281269 -1.26515987887331 -1 17.8474756086184 3252 776 1612 212 1018 3708 2431 1422 193 2356 1700 1351 M10804 GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLE_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. 13/15 Gene Ontology BP GO:0044090 2.75742178809169e-06 3.42492753976787e-06 1435 1798 1612 2.50675022197933e-07 400 1.37359542438978 -1.28494422710265 -1 7.98888497687811 1433 2027 3114 1612 3716 690 595 1842 400 3637 712 1352 M14248 GO_RESPONSE_TO_TEMPERATURE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TEMPERATURE_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. 185/246 Gene Ontology BP GO:0009266 4.13981134305054e-08 1.97691467186943e-07 2275 1875.63636363636 1612 3.76346492813702e-09 770 2.35790751857425 2.51794063984963 1 16.9467897005931 2275 1522 894 1156 770 1612 2680 4522 2184 1635 1382 1353 M14088 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. 82/150 Gene Ontology BP GO:0045621 8.94349601940134e-08 2.47114530749848e-07 795 1639.27272727273 1613 8.13045125724967e-09 172 1.78947156247838 -1.57495689834236 -1 12.6468942204386 791 172 1954 2773 1613 866 2226 1714 3637 1252 1034 1354 M14753 GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS.html Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). 810/1268 Gene Ontology BP GO:0051093 5.03746007933179e-12 1.41200612946571e-10 1615 1468.72727272727 1613 5.03746007934321e-13 40 2.33398327425123 2.61415488365093 1 24.6985599548577 1613 1205 4516 40 442 1213 1737 1752 1801 77 1760 1355 M15444 GO_MYOTUBE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOTUBE_CELL_DEVELOPMENT.html The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 24/39 Gene Ontology BP GO:0014904 2.74934809180594e-07 4.95074174581e-07 4135 1996.45454545455 1613 2.49940766853913e-08 198 2.34198864223172 -0.952397829950885 -1 15.8239250333083 4134 756 1613 1213 2541 4406 3562 451 203 2884 198 1356 M14847 GO_DETERMINATION_OF_ADULT_LIFESPAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETERMINATION_OF_ADULT_LIFESPAN.html The control of viability and duration in the adult phase of the life-cycle. 16/19 Gene Ontology BP GO:0008340 2.13634078256621e-07 4.14528509644728e-07 1785 1664.54545454545 1614 1.94212817274418e-08 950 2.91286197352293 3.19198092266042 1 19.951092341003 1781 2000 1614 1609 2356 1392 950 2220 1384 1925 1079 1357 M10993 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate or extent of lymphocyte migration. 19/39 Gene Ontology BP GO:2000403 1.16593204062407e-07 2.81822430390847e-07 2215 1558.18181818182 1616 1.05993827492261e-08 375 3.11914145643428 -2.86660824675692 -1 21.9360901150934 2213 1931 692 720 1865 1616 1154 4275 375 595 1704 1358 M15907 GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. 61/93 Gene Ontology BP GO:0045071 2.9881115630463e-05 3.2630094116063e-05 170 1933.63636363636 1616 2.71650195392846e-06 170 1.97999904045009 -2.16680367844687 -1 9.47374945310692 170 3052 1912 1957 4238 1431 1206 670 3555 1463 1616 1359 M16536 GO_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 111/235 Gene Ontology BP GO:0042445 1.46469242536613e-08 1.97691467186943e-07 3410 1791.54545454545 1616 1.33153857737964e-09 31 2.60294418158225 -2.53576494328577 -1 18.7196742783262 3410 1616 411 1106 31 3045 3304 1680 1563 599 2942 1360 M11993 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 23/33 Gene Ontology BP GO:0044253 1.67320998202102e-06 2.18999888786042e-06 1425 1803.36363636364 1617 1.52110114052928e-07 623 2.62555324686135 2.79317829656834 1 15.9237057043977 1425 3141 1662 1404 3523 1617 1996 623 1249 2358 839 1361 M16187 GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COLLAGEN_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. 23/33 Gene Ontology BP GO:0010714 1.67320998202102e-06 2.18999888786042e-06 1430 1804.45454545455 1618 1.52110114052928e-07 617 2.62555324686135 2.79317829656834 1 15.9237057043977 1426 3142 1663 1405 3524 1618 1997 617 1250 2367 840 1362 M10187 GO_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. 98/182 Gene Ontology BP GO:0006694 4.02333709160799e-08 1.97691467186943e-07 1620 1745.18181818182 1620 3.6575792410785e-09 740 2.22762406687583 -2.09551249980862 -1 16.0041653626082 1620 2227 1617 2251 740 1592 2195 785 1374 2470 2326 1363 M13359 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. 156/215 Gene Ontology BP GO:0051092 1.9621314742328e-07 3.92510651315787e-07 1190 1834.27272727273 1620 1.78375604475545e-08 1086 2.00488611383244 -2.12139612013812 -1 13.7481178975035 1186 2621 1856 1620 2287 1383 2350 1569 2980 1086 1239 1364 M11276 GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VOLTAGE_GATED_CALCIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity. 23/32 Gene Ontology BP GO:1901385 6.76906309970359e-08 2.19879876316322e-07 2515 1598.90909090909 1621 6.15369391634302e-09 653 2.27243500516748 2.72186779212506 1 16.2150818589848 2512 773 1605 1857 1337 1947 2037 1639 653 1607 1621 1365 M13518 GO_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_GROWTH.html The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. 77/100 Gene Ontology BP GO:0035265 1.24903922950919e-07 2.91317269920114e-07 1625 1427.36363636364 1621 1.13549027311163e-08 189 2.84136788534504 3.17561987141294 1 19.928381888345 1621 198 466 189 1932 1960 2910 2809 1773 576 1267 1366 M16157 GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. 46/60 Gene Ontology BP GO:0040018 9.31292064950097e-08 2.50682609814375e-07 1625 1575 1622 8.46629185793682e-09 155 2.18606193792271 -2.53879797210574 -1 15.4601298278675 2725 402 1622 556 1661 3194 3385 155 377 1622 1626 1367 M10756 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. 87/124 Gene Ontology BP GO:0051149 6.65740610241702e-08 2.18361447198576e-07 2545 1737.09090909091 1623 6.05218754897854e-09 156 2.24933983181258 2.43452768717679 1 16.0564413639202 2544 156 1393 1209 1319 2101 1674 1459 2148 1623 3482 1368 M10971 GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PROSTAGLANDIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. 41/75 Gene Ontology BP GO:0071379 1.88215586970037e-07 3.81942274526354e-07 2035 1669.63636363636 1623 1.71105093702145e-08 520 2.4957573278706 2.80672863353593 1 17.1737906291064 2035 520 1195 1623 2251 1841 1156 650 3342 1350 2403 1369 M12723 GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 215/303 Gene Ontology BP GO:0050730 2.64048438804311e-08 1.97691467186943e-07 1625 1447.72727272727 1623 2.40044038157703e-09 261 2.20205295793493 2.50706715707492 1 15.8191537642606 1623 1446 524 644 301 1627 1777 2219 2258 261 3245 1370 M16269 GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 799/1010 Gene Ontology BP GO:0051129 5.79013304366747e-08 2.0762333639785e-07 1665 1838.63636363636 1623 5.79013319453286e-09 706 1.94460258608605 2.12210231787874 1 13.9117766301717 1664 2108 4611 706 1275 1122 1623 1991 1507 1494 2124 1371 M15467 GO_NEGATIVE_REGULATION_OF_OSSIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSSIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation. 71/94 Gene Ontology BP GO:0030279 2.27678682701124e-08 1.97691467186943e-07 2830 1692.45454545455 1625 2.06980622779434e-09 190 2.32472115788164 2.4135041295182 1 16.7066803784176 2828 232 954 648 190 2426 3127 2465 1625 1493 2629 1372 M16750 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. 28/47 Gene Ontology BP GO:0002483 9.91332411124444e-07 1.39355580331179e-06 105 1856.54545454545 1625 9.01211688931549e-08 102 1.58523650810552 -1.30449553277468 -1 9.90535186026573 102 665 2571 3343 3272 593 773 1625 4128 1987 1363 1373 M13477 GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of osteoblast proliferation. 40/49 Gene Ontology BP GO:0033688 2.95887335186379e-08 1.97691467186943e-07 2640 1869.45454545455 1627 2.68988490150813e-09 399 2.53299815437918 3.19268176871023 1 18.2136021200632 2637 519 1627 868 399 3319 3833 2278 1500 1983 1601 1374 M16964 GO_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_CHEMOTAXIS.html The directed movement of a motile cell or organism towards a higher concentration of a chemical. 42/52 Gene Ontology BP GO:0050918 8.46705107412008e-07 1.2208611294664e-06 1655 1722.27272727273 1627 7.69732212072869e-08 935 2.54560368599502 2.67930022266167 1 16.1325782646132 1653 2711 1038 1737 3193 981 1627 1188 2451 1431 935 1375 M15999 GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 586/759 Gene Ontology BP GO:0045936 3.54757877346416e-08 1.97691467186943e-07 2185 1957.81818181818 1628 3.54757883009808e-09 710 2.00292118092752 2.3025322630043 1 14.3783993397626 2185 1244 4584 2275 710 900 2650 1628 2495 1399 1466 1376 M13649 GO_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_REGENERATION.html The regrowth of lost or destroyed tissues. 57/80 Gene Ontology BP GO:0042246 3.55398839076421e-08 1.97691467186943e-07 4130 2195.18181818182 1630 3.2308985892519e-09 316 2.41963345090265 2.52845008125646 1 17.3933879856328 4130 316 1029 816 602 3109 3690 4036 1630 1148 3641 1377 M15568 GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 92/182 Gene Ontology BP GO:0033559 8.12769540452353e-08 2.36807556150582e-07 1885 1698.18181818182 1631 7.38881427708519e-09 120 2.18848959292381 -2.33948011133046 -1 15.5358304107769 1883 120 1066 2237 1514 993 1600 2619 3351 1631 1666 1378 M10653 GO_CELLULAR_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 520/821 Gene Ontology BP GO:0071396 3.71255117235602e-08 1.97691467186943e-07 1635 1723.90909090909 1632 3.71255123437968e-09 165 2.3535020290375 2.50148144205576 1 16.9149151869543 1632 1266 4253 224 1215 973 2076 2632 2484 165 2043 1379 M16089 GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. 106/204 Gene Ontology BP GO:0002698 2.01435920088903e-07 3.99352934032239e-07 675 1754.54545454545 1632 1.83123580484306e-08 592 1.85586928472646 -1.95248251479146 -1 12.7028249590689 675 1632 2185 2829 2306 871 1894 592 3916 1579 821 1380 M12439 GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 45/63 Gene Ontology BP GO:0010464 1.84206339730294e-07 3.76918249237052e-07 1250 1613.72727272727 1633 1.67460322867201e-08 279 2.44983093591149 3.06417645206935 1 16.8708851297067 1250 2309 1633 1269 2231 839 1314 2435 1892 2300 279 1381 M14323 GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPOLYSACCHARIDE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. 36/54 Gene Ontology BP GO:0031663 1.75765567198602e-06 2.2870167342704e-06 545 1735.36363636364 1635 1.59787006930833e-07 541 2.05481859573099 -2.08866324260217 -1 12.3959271597412 541 2330 1766 850 3545 706 1372 1635 3392 1058 1894 1382 M10568 GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANIC_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 55/97 Gene Ontology BP GO:0032890 7.42481319837303e-08 2.27586665428391e-07 1805 1503.36363636364 1636 6.74983040814017e-09 346 2.54930868802194 2.8251414419743 1 18.1633456878325 1823 346 859 980 1424 1803 2196 2665 1804 1001 1636 1383 M12233 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 39/43 Gene Ontology BP GO:0010656 2.39206922938814e-07 4.46283004183762e-07 1960 1601.81818181818 1636 2.17460862679897e-08 518 2.4392350175875 2.49366809053077 1 16.6042981130896 1959 518 1175 669 2447 1977 1636 3013 2116 1137 973 1384 M10947 GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. 248/324 Gene Ontology BP GO:0031668 7.27865275915337e-08 2.25729558068868e-07 1675 1550.36363636364 1637 6.61695727269642e-09 412 2.31771965160812 2.64059651598706 1 16.5119438404209 1671 1414 412 1736 1406 707 1975 1949 2891 1256 1637 1385 M12396 GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. 86/132 Gene Ontology BP GO:0040014 8.75335945895493e-08 2.45512816355666e-07 4060 1934.54545454545 1637 7.95759982475779e-09 167 2.16194314169823 1.96086859116993 1 15.309426474915 4058 167 1637 619 1582 3778 3637 867 632 2309 1994 1386 M12510 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine. 134/170 Gene Ontology BP GO:0033135 9.53184342973258e-08 2.52860133857159e-07 1690 1810.63636363636 1637 8.66531258428602e-09 1058 2.14484545641336 2.30348396553087 1 15.1578141573174 1688 1600 1470 1058 1689 1608 1761 2757 1637 1602 3047 1387 M14335 GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 18/39 Gene Ontology BP GO:0051350 5.05940727409103e-07 7.97473646556421e-07 1885 1770.90909090909 1638 4.59946221601705e-08 776 3.53505735494804 3.36217322475973 1 23.1527398370834 1885 2443 776 1131 2918 1397 952 2765 1638 891 2684 1388 M13010 GO_LEUKOCYTE_TETHERING_OR_ROLLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_TETHERING_OR_ROLLING.html Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). 15/17 Gene Ontology BP GO:0050901 5.21498123949121e-07 8.18115566667316e-07 805 1882.63636363636 1640 4.74089315970434e-08 803 2.93633390252888 3.40039481890246 1 19.1770951777244 803 2008 933 2081 2932 1387 1239 2512 3833 1341 1640 1389 M14170 GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ADHESION_TO_VASCULAR_ENDOTHELIAL_CELL.html The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. 15/17 Gene Ontology BP GO:0061756 5.21498123949121e-07 8.18115566667316e-07 805 1884.09090909091 1641 4.74089315970434e-08 804 2.93633390252888 3.40039481890246 1 19.1770951777244 804 2009 934 2082 2933 1388 1240 2517 3834 1343 1641 1390 M15602 GO_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINESIS.html The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. 102/118 Gene Ontology BP GO:0000910 3.46483202850854e-08 1.97691467186943e-07 3165 1788.27272727273 1642 3.14984734825181e-09 41 1.8109701943957 2.18677726104747 1 12.989599233177 3164 41 1642 692 573 3631 3450 2329 360 680 3109 1391 M16967 GO_RESPONSE_TO_NITRIC_OXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITRIC_OXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. 21/40 Gene Ontology BP GO:0071731 5.08509965901092e-07 8.00168032241387e-07 1465 2039.54545454545 1642 4.62281894035072e-08 398 1.80180717081094 1.78316385472622 1 11.7425750885127 1465 1956 2471 4367 2923 1381 1068 398 4329 1642 435 1392 M10466 GO_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DEGRANULATION.html The regulated exocytosis of secretory granules by a leukocyte. 35/68 Gene Ontology BP GO:0043299 2.1802400430476e-07 4.19624379491385e-07 1360 1579.45454545455 1643 1.98203659919399e-08 349 2.06959872111708 -1.97982750880144 -1 14.1307281604282 1356 578 1764 1203 2375 1797 1431 349 1643 2934 1944 1393 M10111 GO_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSPORT.html The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 894/1474 Gene Ontology BP GO:0006811 9.23283472542366e-19 8.59207599547926e-17 2275 1751.63636363636 1644 9.23283472542371e-20 26 2.3210583401857 -2.1110608955555 -1 40.1313315111634 2271 1184 4225 1671 698 1176 2223 1624 1644 26 2526 1394 M16790 GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of organelle assembly. 57/66 Gene Ontology BP GO:1902117 2.58629572662302e-07 4.71922902587329e-07 1435 1712 1644 2.35117820969558e-08 420 1.95799814922654 -1.77312506023917 -1 13.2548556774892 1431 1729 2475 1005 2508 1561 1530 1793 420 2736 1644 1395 M16333 GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation. 31/61 Gene Ontology BP GO:0046640 9.63371514246776e-07 1.36414110036222e-06 320 1916 1645 8.75792669185187e-08 318 1.49473432362169 -1.55073139238798 -1 9.34833813314578 318 608 2687 2807 3252 658 1645 1582 4271 2093 1155 1396 M15116 GO_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADHERENS_JUNCTION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments. 92/111 Gene Ontology BP GO:0034332 9.1798969036976e-08 2.49206886189644e-07 1700 1451.54545454545 1646 8.34536116976851e-09 96 2.7596997727369 3.20555788198025 1 19.5542898873338 1699 96 409 907 1646 2343 2930 1663 737 719 2818 1397 M13195 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway. 191/225 Gene Ontology BP GO:2001236 3.72849728715651e-08 1.97691467186943e-07 1410 1571.36363636364 1651 3.38954304576911e-09 656 2.21757634144587 2.41573248788332 1 15.9314682517457 1409 2174 1047 663 656 1326 1896 2917 1651 1661 1885 1398 M13328 GO_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_NUCLEAR_DIVISION.html A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. 419/475 Gene Ontology BP GO:0007067 2.22033930718406e-07 4.25328892397176e-07 220 1727.18181818182 1652 2.01849048297341e-08 219 1.62607469794051 1.77207947198524 1 11.0679231202832 219 2599 3773 2734 2387 722 561 1228 1753 1652 1371 1399 M16945 GO_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. 42/58 Gene Ontology BP GO:0019933 3.22316033413443e-08 1.97691467186943e-07 1260 1815.63636363636 1654 2.93014580123279e-09 485 2.23412143143607 2.73608081915157 1 16.0511749704087 1257 3675 1711 2803 485 1597 1654 1110 2355 1686 1639 1400 M12913 GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 37/48 Gene Ontology BP GO:0070169 9.20844512328884e-08 2.49836123374128e-07 3215 1881.81818181818 1655 8.37131409883889e-09 735 3.30310000259609 4.14936760819498 1 23.4230036981974 3211 2327 735 1524 1647 3007 3012 1095 751 1655 1736 1401 M16484 GO_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 114/170 Gene Ontology BP GO:0046165 6.33185282251235e-08 2.13803419326197e-07 725 1767.81818181818 1656 5.75623000431849e-09 725 2.13698217268372 -2.12879731012378 -1 15.2698790878012 725 2639 1733 2704 1271 1289 1515 988 1656 3137 1789 1402 M11875 GO_MEMBRANE_DOCKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DOCKING.html The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. 69/78 Gene Ontology BP GO:0022406 3.48752348077922e-08 1.97691467186943e-07 1210 1972.63636363636 1657 3.17047594187707e-09 277 1.53287606351345 -1.1848481122376 -1 10.9775378961226 1206 277 3439 3868 583 1657 1265 1398 2707 3576 1723 1403 M12021 GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition. 80/93 Gene Ontology BP GO:1902749 1.3286406781565e-07 3.02306360658298e-07 240 1562.18181818182 1658 1.20785523490617e-08 239 1.75627005669871 2.07655154898017 1 12.2442055256214 239 2252 2796 1658 1986 422 344 783 3070 2877 757 1404 M15548 GO_CELL_VOLUME_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_VOLUME_HOMEOSTASIS.html Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. 33/45 Gene Ontology BP GO:0006884 9.31504613014415e-08 2.50682609814375e-07 2310 1875.63636363636 1662 8.46822411323058e-09 435 2.82440398637767 2.86453714467659 1 20.0075974805145 2310 532 636 435 1662 3052 4072 4213 568 972 2180 1405 M11130 GO_GLIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_DEVELOPMENT.html The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 86/123 Gene Ontology BP GO:0021782 7.42084887019268e-08 2.27586665428391e-07 2320 1608.36363636364 1663 6.74622647318758e-09 999 2.44385408930037 2.98139090750884 1 17.4073230803599 2317 1663 1037 999 1423 2092 1942 1175 1077 2097 1870 1406 M11239 GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION.html Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. 151/245 Gene Ontology BP GO:0022408 4.9912144201817e-08 2.02079099099266e-07 2255 1791.90909090909 1663 4.53746775765371e-09 386 2.2120009763808 -2.09484711753687 -1 15.8683705891762 2251 1540 601 1138 1009 2157 2981 3985 1663 386 2000 1407 M10474 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY_INVOLVED_IN_NEURAL_TUBE_CLOSURE.html Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. 19/21 Gene Ontology BP GO:0090178 7.02429055680455e-07 1.04615641370666e-06 490 1768.54545454545 1664 6.3857207268752e-08 468 1.49884367716672 1.54817678967471 1 9.56079851740819 486 1960 2569 3144 3089 611 468 1161 3341 1664 961 1408 M15543 GO_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. 162/196 Gene Ontology BP GO:0006643 1.75815599948423e-08 1.97691467186943e-07 1450 1726.09090909091 1664 1.59832364866795e-09 71 1.73369656563887 -1.59130791595143 -1 12.4305105522967 1450 1544 2985 3268 71 759 1491 1824 1664 2012 1919 1409 M10247 GO_LENS_FIBER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LENS_FIBER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. 28/49 Gene Ontology BP GO:0070306 5.08324958707145e-08 2.02998167617902e-07 2575 1569.63636363636 1665 4.62113609502125e-09 16 2.47657837304212 -1.31116889547127 -1 17.7746463742927 2575 1877 1665 284 1024 2776 3537 504 16 2721 287 1410 M12425 GO_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMOCYTE_AGGREGATION.html The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. 45/63 Gene Ontology BP GO:0071594 2.06430633826491e-07 4.05879276381118e-07 860 1569.45454545455 1665 1.87664230178468e-08 858 1.9077205362763 1.9061696142873 1 13.0463953927032 858 1763 2000 1415 2324 1254 1042 1665 2161 1074 1708 1411 M14185 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 111/165 Gene Ontology BP GO:0002065 9.33700886183392e-08 2.50783780632741e-07 3810 2002.63636363636 1665 8.48819023464133e-09 121 2.85405342536289 3.0056255772786 1 20.2182765522596 3806 1614 346 121 1665 3284 3237 3840 873 537 2706 1412 M15404 GO_ADULT_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADULT_HEART_DEVELOPMENT.html The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. 14/29 Gene Ontology BP GO:0007512 1.05773938405939e-07 2.65318671376192e-07 3795 1924.63636363636 1665 9.61581304467743e-09 22 3.28302436015467 3.92685356775578 1 23.1874349286964 3794 953 1146 151 1784 4477 4352 862 22 1965 1665 1413 M12296 GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation. 14/21 Gene Ontology BP GO:0048714 4.06621610340792e-07 6.72377112879102e-07 1760 1576.81818181818 1666 3.69656077723521e-08 495 3.09503787259033 3.97096733552228 1 20.5042942011054 1757 2511 1376 1060 2775 1666 1931 495 693 1955 1126 1414 M14620 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 77/87 Gene Ontology BP GO:0071230 3.72636539588698e-07 6.28900188141535e-07 1125 1637.81818181818 1666 3.38760547914529e-08 371 2.80651899028612 3.23682089599782 1 18.670276700329 1123 1666 432 981 2723 1922 2238 3209 371 1090 2261 1415 M15598 GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 55/82 Gene Ontology BP GO:0050994 5.44772161408764e-08 2.05617623085131e-07 3115 2055.18181818182 1666 4.95247431726013e-09 868 2.14491741545745 -2.14326243493811 -1 15.3662475004455 3112 1722 1666 1188 1109 3785 4395 2286 1033 868 1443 1416 M16837 GO_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 132/200 Gene Ontology BP GO:0051592 5.26456985248043e-08 2.04581932255101e-07 3545 2150.27272727273 1666 4.7859727076917e-09 433 2.51729460994499 2.47697899696819 1 18.0595607527274 3545 1583 433 1111 1070 3145 3286 3522 1666 613 3679 1417 M10281 GO_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AUTOPHAGY.html Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 299/374 Gene Ontology BP GO:0010506 4.73063028856627e-08 1.98252330758246e-07 1140 2064.36363636364 1667 4.30057308208033e-09 432 1.45950595303498 -1.36691339297148 -1 10.4447538537713 1137 1387 3973 3519 957 432 2081 1667 2739 4369 447 1418 M14633 GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_COMMUNICATION_BY_ELECTRICAL_COUPLING.html Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. 19/21 Gene Ontology BP GO:0010649 7.30463295175486e-07 1.07934128690109e-06 770 1649.63636363636 1668 6.64057761554936e-08 289 2.23469865317299 2.61236240013569 1 14.2774741797738 768 1972 2040 3122 3116 927 289 1108 2692 1668 444 1419 M12292 GO_KIDNEY_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. 25/30 Gene Ontology BP GO:0061440 1.49884204997285e-06 1.99203429263743e-06 1670 1670.90909090909 1669 1.36258461011153e-07 131 3.36690359348536 3.6737975459539 1 20.6013670618263 1669 2792 1030 3347 4221 860 393 131 1771 1911 255 1420 M16621 GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. 17/24 Gene Ontology BP GO:0043011 1.34498691797052e-06 1.811352859426e-06 1175 2035.09090909091 1669 1.22271612749029e-07 916 1.94142725683821 -1.54789864222583 -1 11.9178180275363 1174 2472 2303 3888 3423 1018 1055 1445 916 3023 1669 1421 M16715 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. 19/21 Gene Ontology BP GO:0010664 7.48086129101974e-07 1.1011846753279e-06 2035 1663.54545454545 1669 6.80078530436969e-08 498 2.373714280682 2.85960084547828 1 15.1503885584249 2034 888 1710 1063 3130 2167 1563 498 2816 1669 761 1422 M14598 GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT.html The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. 25/30 Gene Ontology BP GO:0061437 4.32778673325235e-07 7.02729470408379e-07 1670 1665.81818181818 1670 3.93435234964028e-08 63 3.36690359348536 3.6737975459539 1 22.2456333971861 1670 2793 1031 3348 4222 861 394 63 1772 1914 256 1423 M15880 GO_LIPID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_OXIDATION.html The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. 79/91 Gene Ontology BP GO:0034440 1.31718806628842e-08 1.94567494363175e-07 1440 1771.81818181818 1671 1.19744370379519e-09 22 1.60050213659627 -1.26534967403868 -1 11.4787736886741 1439 1671 3101 2349 22 1148 1694 1578 1471 3171 1846 1424 M16930 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides. 49/86 Gene Ontology BP GO:0045980 4.54431969504572e-07 7.32919221526785e-07 1780 1611.18181818182 1671 4.13120057610964e-08 429 2.54475483463978 2.92523586013013 1 16.7357866100719 1776 429 1161 2288 2849 1209 1593 1986 1716 1671 1045 1425 M12013 GO_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. 34/47 Gene Ontology BP GO:0046513 8.61767744738018e-08 2.44742660185759e-07 3800 2657.45454545455 1672 7.83425253176861e-09 544 2.05627439351148 -1.7998834160209 -1 14.5586517374154 3799 544 1672 1121 1564 4248 4498 4575 1320 1293 4598 1426 M12147 GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol. 20/22 Gene Ontology BP GO:0045540 1.26334572520052e-06 1.71931782958702e-06 1385 2162.90909090909 1672 1.14849677334085e-07 666 1.81629638150189 -1.46356002409134 -1 11.1867815562399 1384 3467 2941 3166 3385 1333 666 820 1672 3399 1559 1427 M12706 GO_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_REMODELING.html The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. 61/78 Gene Ontology BP GO:0046849 1.87131399856095e-07 3.80672034126585e-07 3150 1855.63636363636 1672 1.70119468884948e-08 307 2.48266998053312 3.04143181630411 1 17.0870173919253 3146 307 1063 632 2244 3386 3721 1825 1265 1672 1151 1428 M13363 GO_POSITIVE_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HAIR_CYCLE.html Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 10/13 Gene Ontology BP GO:0042635 1.17422841728552e-06 1.61096475569977e-06 2320 1610.54545454545 1672 1.06748094910807e-07 186 3.84613512827789 4.08159849699205 1 23.932535710929 2318 1057 748 186 3354 1982 2606 1956 269 1568 1672 1429 M16438 GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION_GABAERGIC.html Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). 14/17 Gene Ontology BP GO:0032230 4.91439114339209e-07 7.79425154846525e-07 2620 1617.63636363636 1672 4.46762931016008e-08 215 2.9006705503584 -2.99673773033141 -1 19.0086717861895 2616 943 1119 215 2899 2578 2168 1672 783 849 1952 1430 M11339 GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/33 Gene Ontology BP GO:0032373 2.37778194243846e-07 4.43795402252954e-07 2340 1878.18181818182 1674 2.1616201813014e-08 642 3.13533878988715 4.23383998520386 1 21.3832876905306 2336 670 1017 642 2445 3162 3209 1366 2856 1674 1283 1431 M16329 GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 370/682 Gene Ontology BP GO:0098660 3.13942951181574e-11 7.81163931469446e-10 4075 2167.72727272727 1674 2.85402682896412e-12 136 2.41616285519452 -2.11994009729783 -1 23.6349788260585 4072 1323 136 1674 983 3207 3498 3285 1577 147 3943 1432 M10396 GO_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of a pattern along a line or around a point. 80/126 Gene Ontology BP GO:0009798 7.93750498977211e-08 2.34880885205277e-07 2815 1836.90909090909 1675 7.21591388741262e-09 610 2.43686469126163 2.7713837915145 1 17.3211823929452 2814 1675 1055 610 1487 1911 1854 3792 659 1457 2892 1433 M16074 GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. 205/259 Gene Ontology BP GO:0030178 1.3107071027825e-07 3.00411010867397e-07 1440 1603.90909090909 1675 1.19155198261026e-08 636 1.96662628877413 2.36356942450372 1 13.7300917105358 1440 1487 2029 636 1971 1675 2242 1093 736 2638 1696 1434 M16160 GO_PROTEIN_INSERTION_INTO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_INSERTION_INTO_MEMBRANE.html The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. 22/30 Gene Ontology BP GO:0051205 2.68562165769472e-08 1.97691467186943e-07 1890 1462.18181818182 1675 2.44147426407192e-09 224 2.51839563378572 -2.84576281719317 -1 18.1079502423467 1890 2809 1840 811 315 2071 1131 1675 224 2178 1140 1435 M10849 GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. 21/53 Gene Ontology BP GO:0002701 1.97270324377916e-06 2.53353248504124e-06 610 1660.63636363636 1678 1.79336819333766e-07 453 2.2197071826798 -2.63036118927999 -1 13.2932113132494 610 2432 1926 2312 3589 1149 1678 453 1479 1991 648 1436 M16583 GO_HEMOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOSTASIS.html The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. 303/448 Gene Ontology BP GO:0007599 2.81011172435376e-08 1.97691467186943e-07 2550 1780.81818181818 1678 2.55464705477089e-09 353 2.31564542971673 2.62703744064891 1 16.6410158435771 2549 1365 357 1301 353 3015 3454 2457 1678 523 2537 1437 M11551 GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore. 42/70 Gene Ontology BP GO:0003333 3.05471163312307e-08 1.97691467186943e-07 2150 1628.36363636364 1680 2.77701061412537e-09 420 2.54659563668127 2.7035871871506 1 18.3119823639559 2148 420 660 1680 428 2791 2477 2738 1071 504 2995 1438 M11869 GO_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATION_TRANSPORT.html The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 568/954 Gene Ontology BP GO:0006812 8.7530488334679e-11 1.97708428262748e-09 1685 1818.63636363636 1681 8.75304883381265e-12 96 2.27392487528857 -2.05708886367135 -1 21.2472512664999 2334 1235 4329 1673 704 1346 2383 1681 1684 96 2540 1439 M15438 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. 28/30 Gene Ontology BP GO:0033137 3.85390499676314e-08 1.97691467186943e-07 1770 1775.18181818182 1681 3.50355005843172e-09 688 2.38957290537198 2.69915973153082 1 17.1758945015339 1770 3706 1841 2509 688 1252 1231 1911 1258 1680 1681 1440 M15739 GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRIGLYCERIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. 28/55 Gene Ontology BP GO:0010866 3.92213957885263e-08 1.97691467186943e-07 1585 1995.54545454545 1681 3.56558149888743e-09 697 1.98414095005318 -1.70996917096927 -1 14.242520972523 1583 697 2251 2771 713 1443 2035 4365 2781 1681 1631 1441 M15839 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 28/33 Gene Ontology BP GO:0032376 2.37778194243846e-07 4.43795402252954e-07 2340 1874.90909090909 1682 2.1616201813014e-08 643 3.13533878988715 4.23383998520386 1 21.3832876905306 2337 671 1018 643 2446 3163 3210 1313 2857 1682 1284 1442 M10076 GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that activates or increases the frequency, rate or extent of protein maturation. 21/42 Gene Ontology BP GO:1903319 5.31677358220727e-08 2.04903449305918e-07 4275 2440.45454545455 1683 4.83343064608958e-09 399 3.17841861446902 -2.93976950384697 -1 22.8299565951191 4272 794 720 1683 1081 4555 4592 3447 399 1028 4274 1443 M13739 GO_MAMMARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. 155/219 Gene Ontology BP GO:0030879 7.59574268162009e-08 2.29469567498056e-07 4275 2239.18181818182 1683 6.90522085806499e-09 263 2.5544598201442 -2.57360727767956 -1 18.190410256212 4274 2622 563 263 1446 4285 4252 1683 1365 955 2923 1444 M10843 GO_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein. 27/41 Gene Ontology BP GO:0033233 3.36244131143732e-07 5.7838962743504e-07 1685 1926 1684 3.05676529577004e-08 475 1.83054313130503 -1.81204476282655 -1 12.2101333345465 1684 2394 2462 2588 2663 1357 920 1615 1502 3526 475 1445 M11135 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. 74/148 Gene Ontology BP GO:0003073 1.54684966152091e-08 1.97691467186943e-07 3200 1844.90909090909 1685 1.40622697490638e-09 40 2.48870812146727 -2.13566678874021 -1 17.8931557210104 3199 1685 700 2260 40 3412 4015 270 2811 709 1193 1446 M11484 GO_MEMBRANE_RAFT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_RAFT_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. 21/25 Gene Ontology BP GO:0031579 1.00011394010568e-07 2.57982072081111e-07 1330 1637 1686 9.09194532336899e-09 786 1.68385572497329 -2.04987979007073 -1 11.8598237194997 1326 786 2334 1204 1737 1442 2252 1686 2305 1992 943 1447 M10665 GO_KERATAN_SULFATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 31/38 Gene Ontology BP GO:0042339 1.72552651607245e-08 1.97691467186943e-07 3445 2139.54545454545 1689 1.56866048146025e-09 67 2.34540579215522 2.68537045633765 1 16.8563374487087 3442 603 1027 2238 67 4202 3990 1689 1241 820 4216 1448 M14269 GO_RESPONSE_TO_VITAMIN_D http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_D.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. 43/53 Gene Ontology BP GO:0033280 7.33810912605964e-08 2.26356255727441e-07 2885 1739.18181818182 1691 6.67100851892963e-09 479 2.85963173316819 2.76821962698963 1 20.3953721873856 2885 479 494 2074 1413 2269 1444 2090 1691 787 3505 1449 M15864 GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of stem cell proliferation. 73/102 Gene Ontology BP GO:2000648 1.41044733222071e-07 3.13494574129188e-07 1415 1642.90909090909 1691 1.2822249296784e-08 376 2.33615813841411 3.05816180588358 1 16.28456751411 1411 1691 1264 859 2037 1595 1718 2253 2806 2062 376 1450 M14045 GO_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 273/420 Gene Ontology BP GO:0006631 2.40138935666503e-08 1.97691467186943e-07 785 1782.81818181818 1692 2.18308125716107e-09 232 1.87002375660192 -1.81492197781004 -1 13.4168624370192 784 2606 2045 3275 232 872 1285 1364 2984 2472 1692 1451 M16126 GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. 71/105 Gene Ontology BP GO:2000177 6.04071227568318e-08 2.10070509856157e-07 1215 1594.81818181818 1692 5.4915567650434e-09 1098 1.96725999760538 2.23351756025589 1 14.0643821065848 1215 1692 1933 1427 1226 1737 1830 1098 1272 2122 1991 1452 M16172 GO_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_IMPORT.html The directed movement of amino acids into a cell or organelle. 13/29 Gene Ontology BP GO:0043090 6.84706505970831e-08 2.20507296091218e-07 2910 1894.27272727273 1692 6.22460479346336e-09 697 2.58423980179775 2.06921798830056 1 18.4520487174646 2909 989 1230 1692 1350 2569 1789 3440 920 697 3252 1453 M16190 GO_PROTEIN_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HYDROXYLATION.html The addition of a hydroxy group to a protein amino acid. 17/20 Gene Ontology BP GO:0018126 2.47992375642429e-06 3.11446295240006e-06 480 1582.09090909091 1694 2.25447868353925e-07 158 2.50267361112275 2.86207140224404 1 14.7600769411646 476 2861 2079 1694 4029 1245 1825 158 355 2130 551 1454 M11334 GO_TISSUE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TISSUE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. 198/311 Gene Ontology BP GO:0001894 3.17325832502315e-08 1.97691467186943e-07 2515 1749 1695 2.88478033708537e-09 239 2.51280055169803 2.82178595075794 1 18.0674688114349 2513 1481 239 1348 689 2348 2793 1695 3266 575 2292 1455 M14634 GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_ASSOCIATION_NEURON_DIFFERENTIATION.html The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. 3/19 Gene Ontology BP GO:0021527 1.13290333926133e-06 1.56514229144388e-06 2745 1841.54545454545 1696 1.13290391682324e-07 4 4.21198930262721 2.9675272003762 1 26.2767854557139 2742 1132 4506 494 3378 2412 589 1222 4 1696 2082 1456 M15000 GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 24/34 Gene Ontology BP GO:0050858 3.64015298555105e-08 1.97691467186943e-07 1835 1541.09090909091 1696 3.30923004161962e-09 429 2.09019020021038 -2.38729431177322 -1 15.0098064790095 1835 680 1367 1696 631 2597 2604 2113 429 711 2289 1457 M12509 GO_PROTEIN_TRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRIMERIZATION.html The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. 48/65 Gene Ontology BP GO:0070206 1.09455564141758e-06 1.51802306990044e-06 1265 1635.90909090909 1697 9.95051078170067e-08 379 2.75446138253456 3.23343489871305 1 17.1842244505199 1263 379 603 1728 3320 2015 1697 2791 744 1361 2094 1458 M14256 GO_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_IN_THYMUS.html The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. 45/63 Gene Ontology BP GO:0033077 2.06430633826491e-07 4.05879276381118e-07 860 1573.45454545455 1698 1.87664230178468e-08 859 1.9077205362763 1.9061696142873 1 13.0463953927032 859 1764 2001 1416 2325 1255 1043 1698 2162 1076 1709 1459 M10453 GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell activation. 68/140 Gene Ontology BP GO:0046634 7.43110086445292e-07 1.0969832589562e-06 280 1953.81818181818 1699 6.75554852228306e-08 280 1.65566140880769 -1.68454947275061 -1 10.5361227500094 280 1699 2669 3428 3120 622 876 1553 3910 2063 1272 1460 M16303 GO_PENTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. 13/18 Gene Ontology BP GO:0019321 9.6288323106122e-08 2.53938011162528e-07 280 1383.72727272727 1699 8.75348430185578e-09 152 1.63884415673322 -1.49771050073846 -1 11.5519089997964 278 2506 2589 2278 1699 430 442 152 2059 1758 1030 1461 M12068 GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization. 12/17 Gene Ontology BP GO:0032460 3.16827887512313e-08 1.97691467186943e-07 1170 1351.45454545455 1703 2.88025356431851e-09 11 3.02253483899173 -2.82793461122932 -1 21.7554885779106 1167 2048 1756 1158 2368 1703 1779 11 167 2553 156 1462 M16215 GO_DNA_PACKAGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_PACKAGING.html Any process in which DNA and associated proteins are formed into a compact, orderly structure. 152/328 Gene Ontology BP GO:0006323 6.58207280600909e-07 9.88585692910274e-07 405 1738.72727272727 1703 5.98370434115291e-08 401 1.98492220624063 1.81202978512246 1 12.7507257755512 401 3010 2139 2785 3062 439 836 745 2775 1231 1703 1463 M10883 GO_ASSOCIATIVE_LEARNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASSOCIATIVE_LEARNING.html Learning by associating a stimulus (the cause) with a particular outcome (the effect). 70/113 Gene Ontology BP GO:0008306 9.8654167142408e-08 2.57032100060153e-07 955 1538.90909090909 1704 8.96856105148525e-09 274 2.07345115570584 1.96350978295851 1 14.6335960688288 954 1704 1851 2861 1719 410 926 1181 2321 2727 274 1464 M10905 GO_METAL_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METAL_ION_TRANSPORT.html The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 413/695 Gene Ontology BP GO:0030001 7.05299336009754e-17 4.89814598575132e-15 3835 1982 1704 6.41181214554318e-18 40 2.39010948621403 -2.13717756218128 -1 36.799199294507 3832 1290 40 1273 669 2357 3765 3350 1704 61 3461 1465 M14815 GO_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLASMA_MEMBRANE_FUSION.html The joining of two or more lipid bilayer membranes that surround a cell. 17/32 Gene Ontology BP GO:0045026 1.13707882086717e-07 2.76283433602869e-07 1710 1823.09090909091 1708 1.03370807239777e-08 953 2.23496698281783 -1.98567976507069 -1 15.7066608840262 1708 961 2186 3313 1850 1632 1430 953 1781 3020 1220 1466 M16310 GO_ALKALOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALKALOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). 12/31 Gene Ontology BP GO:0009820 2.2037931509193e-06 2.80094223742898e-06 1635 1799.90909090909 1708 2.00345032592294e-07 147 2.95337109466697 -4.09041392966353 -1 17.5854043542076 1631 2917 1708 2287 3630 1327 147 1453 256 2566 1877 1467 M11938 GO_RESPONSE_TO_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METAL_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. 355/517 Gene Ontology BP GO:0010038 1.26811316828068e-08 1.91470828020043e-07 3095 1964.54545454545 1709 1.15283015962752e-09 216 2.37443817034155 2.48585640023317 1 17.1019740109073 3092 1336 216 1105 886 2827 3301 3114 1709 738 3286 1468 M12988 GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 61/84 Gene Ontology BP GO:0046364 1.34316350520597e-07 3.04253649162657e-07 945 1754.36363636364 1710 1.22105780655453e-08 568 1.4872005928865 -1.45432948767657 -1 10.3465284616434 945 1710 2998 3292 1996 988 1065 568 2270 2136 1330 1469 M13960 GO_ANDROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 23/68 Gene Ontology BP GO:0008209 2.51118836666207e-07 4.62205675240452e-07 1485 1799.81818181818 1710 2.28289877572866e-08 1076 3.22417683739136 -3.82575029481064 -1 21.9309514485391 1482 2797 1201 1842 2486 1710 1562 1076 1755 2363 1524 1470 M10613 GO_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 187/221 Gene Ontology BP GO:0051783 1.55203115743833e-07 3.3356124598432e-07 900 1719.72727272727 1711 1.41093751539026e-08 896 1.85429594946083 2.08306286153531 1 12.8484176483956 896 2170 2466 1589 2112 1084 1098 2336 1535 1711 1920 1471 M12673 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE.html Any process that modulates the frequency, rate or extent of protein localization to the cell surface. 37/46 Gene Ontology BP GO:2000008 9.8038850414534e-08 2.56809599576163e-07 3035 1944.27272727273 1711 8.91262316213189e-09 305 2.04215029970772 -2.25957347775318 -1 14.4118086450839 3031 542 2333 305 1711 3560 3069 837 3204 1654 1141 1472 M15805 GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-6 production. 110/195 Gene Ontology BP GO:0032675 1.29853607065874e-07 2.98468319170846e-07 1500 2053.63636363636 1711 1.18048740664001e-08 1367 1.90519815874243 -1.74281736107359 -1 13.3034891845603 1496 1621 1571 3338 1962 1648 2681 1810 3385 1367 1711 1473 M16019 GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. 9/17 Gene Ontology BP GO:0007171 4.19693746208965e-08 1.97691467186943e-07 2835 1879.45454545455 1711 4.19693754135393e-09 184 3.09800670394097 2.36005059123073 1 22.3015411717499 2831 2061 4587 750 927 1711 654 2332 184 871 3766 1474 M10887 GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus. 202/261 Gene Ontology BP GO:0032104 3.30866687243702e-08 1.97691467186943e-07 1100 2008 1712 3.00787902017942e-09 37 1.40092293761585 -1.28571566760957 -1 10.0228331633052 1097 1493 3929 4427 522 119 1712 1948 2530 4274 37 1475 M12069 GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 121/221 Gene Ontology BP GO:0002263 2.79280144338061e-07 5.00767056495183e-07 1250 1835.72727272727 1713 2.53891072537665e-08 1248 2.03975496565711 -2.10646814141535 -1 13.7563211197119 1248 2208 1480 1340 2550 2020 2831 1314 1650 1713 1839 1476 M13209 GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that modulates the frequency, rate or extent of a response to nutrient levels. 202/261 Gene Ontology BP GO:0032107 3.30866687243702e-08 1.97691467186943e-07 1715 1987.72727272727 1713 3.00787902017942e-09 38 1.40092293761585 -1.28571566760957 -1 10.0228331633052 1098 1494 3930 4428 523 120 1713 1715 2531 4275 38 1477 M14307 GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_ALDEHYDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. 95/122 Gene Ontology BP GO:0006081 1.54277268735617e-08 1.97691467186943e-07 1110 1971.90909090909 1714 1.40252063470457e-09 39 1.93344896322346 -2.03880576106021 -1 13.875755278925 1106 2231 2430 3335 39 1400 1684 1617 3149 2986 1714 1478 M15376 GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_HYDROLYSIS_COUPLED_TRANSMEMBRANE_TRANSPORT.html The transport of molecules across a membrane and against an electrochemical gradient, using energy from ATP hydrolysis. 30/38 Gene Ontology BP GO:0090662 9.82762347564476e-08 2.57032100060153e-07 275 1531.90909090909 1714 8.93420355877703e-09 101 1.9010459601979 -1.86995385073081 -1 13.4074246144759 275 1855 2545 2769 1714 696 405 101 2665 2973 853 1479 M12753 GO_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_INFLAMMATORY_RESPONSE.html Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. 68/158 Gene Ontology BP GO:0002526 1.48783290445066e-11 3.88926208112861e-10 3465 2210.36363636364 1715 1.35257536769156e-12 128 3.45355671106446 -2.97957482877261 -1 34.9602280598624 3462 231 128 1282 652 4329 4482 4211 1715 274 3548 1480 M11580 GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that activates or increases the frequency, rate, or extent of a homeostatic process. 205/279 Gene Ontology BP GO:0032846 9.70003787092867e-08 2.5514005773562e-07 1705 1993.45454545455 1716 8.81821663510353e-09 1420 1.98506562042266 2.01144371600227 1 14.0118591403176 1716 2164 1884 1420 1705 1705 1532 3058 2557 1603 2584 1481 M10826 GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 189/257 Gene Ontology BP GO:0046395 3.24469015386376e-08 1.97691467186943e-07 725 1508.90909090909 1718 2.94971836519851e-09 494 1.8794199669854 -1.80170239936056 -1 13.484845718678 722 1488 1950 2231 494 994 1823 809 1718 2639 1730 1482 M12254 GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. 22/26 Gene Ontology BP GO:0050860 3.10634998032975e-08 1.97691467186943e-07 1735 1540.36363636364 1718 2.82395456744609e-09 448 1.94228875418205 -2.37554158909309 -1 13.9397127654027 1734 760 1771 1718 448 2550 2611 1462 697 910 2283 1483 M10714 GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. 37/77 Gene Ontology BP GO:0002286 3.24395386407381e-07 5.625835754579e-07 990 1753.72727272727 1719 2.94904940218441e-08 989 2.21717641308321 -2.35923666812626 -1 14.8417458757221 989 2333 2003 1719 2641 1419 1397 1318 1987 1918 1567 1484 M13128 GO_ORGANIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. 189/257 Gene Ontology BP GO:0016054 3.24469015386376e-08 1.97691467186943e-07 725 1497.54545454545 1719 2.94971836519851e-09 495 1.8794199669854 -1.80170239936056 -1 13.484845718678 723 1489 1951 2232 495 995 1824 674 1719 2640 1731 1485 M10130 GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. 57/102 Gene Ontology BP GO:0018958 2.66556268135454e-08 1.97691467186943e-07 3395 1940.45454545455 1720 2.42323883059183e-09 309 2.88248618488752 2.75834208241929 1 20.7422112342442 3391 1720 576 899 309 3757 3738 1913 619 860 3563 1486 M13703 GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 33/45 Gene Ontology BP GO:0098815 3.20788600637958e-07 5.58409786295704e-07 530 1933.90909090909 1720 2.91626043102832e-08 193 2.59823616617725 -2.30968162127863 -1 17.4210604922064 3468 526 839 193 2632 4483 4384 1720 528 665 1835 1487 M11291 GO_POTASSIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. 15/27 Gene Ontology BP GO:0055075 1.35005981373581e-07 3.05242440541359e-07 1910 1776.72727272727 1723 1.22732717871279e-08 836 2.998276353469 2.42347841934634 1 20.9695112934144 1908 926 836 1139 2000 1723 1195 3375 2195 978 3269 1488 M14904 GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION.html A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. 608/995 Gene Ontology BP GO:0003006 3.86072287499743e-08 1.97691467186943e-07 1700 2305.36363636364 1723 3.86072294207074e-09 803 2.18402906667912 2.17163639946102 1 15.6887476509636 1697 3853 4523 1723 803 1293 1311 3767 1956 1189 3244 1489 M12226 GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 61/71 Gene Ontology BP GO:1902041 3.58497022078387e-08 1.97691467186943e-07 3420 2044.72727272727 1724 3.25906389018373e-09 615 2.1294741414614 -2.05233728196895 -1 15.2940328994216 3417 1715 1724 1534 615 3191 3815 1656 964 1900 1961 1490 M14748 GO_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY.html The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. 33/45 Gene Ontology BP GO:0014896 8.46318717110178e-08 2.41887038741625e-07 2355 2138.72727272727 1725 7.69380681515676e-09 609 2.10634179092854 2.76868173227644 1 14.9274750911187 2355 627 1811 3440 1554 1682 1408 4326 3989 1725 609 1491 M13846 GO_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T cell differentiation. 100/190 Gene Ontology BP GO:0045580 7.86286524766865e-08 2.33849999170963e-07 895 1822.18181818182 1727 7.14805957153616e-09 838 1.83505406558413 -1.73242885536472 -1 13.0193778003424 893 2222 1860 2903 1477 838 2339 1727 3813 1064 908 1492 M14849 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity. 269/358 Gene Ontology BP GO:2000116 2.56249052658377e-08 1.97691467186943e-07 1705 1950.09090909091 1727 2.32953686948259e-09 278 2.07550156252481 2.33009025373081 1 14.9035315285552 1703 2991 1629 3699 278 1295 1987 939 2579 2624 1727 1493 M12209 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT_INTO_CYTOSOL.html Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. 20/30 Gene Ontology BP GO:0010523 2.13260572032646e-08 1.97691467186943e-07 1730 1848.27272727273 1730 1.93873249181747e-09 155 1.97456513285877 2.20311719732575 1 14.1732382031008 1445 2446 2294 2184 155 1730 1726 1239 3545 2250 1317 1494 M10721 GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPASE_C_ACTIVITY.html Any process that modulates the frequency, rate or extent of phospholipase C activity. 47/64 Gene Ontology BP GO:1900274 1.2041814733066e-07 2.85870224249775e-07 4060 1840.90909090909 1733 1.09471049019828e-08 350 3.21712784856813 -3.3081382894953 -1 22.6072516662838 4057 401 502 1194 1902 3793 2984 350 2411 923 1733 1495 M16492 GO_ISOPRENOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 105/195 Gene Ontology BP GO:0006720 1.45094692792166e-08 1.97691467186943e-07 1465 1593.90909090909 1733 1.31904267044633e-09 29 2.60885781599501 2.47726782205913 1 18.7624604929279 1464 2216 686 1856 29 1733 1387 2648 2489 1070 1955 1496 M10034 GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOPAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine. 16/22 Gene Ontology BP GO:0042053 2.42247467706695e-07 4.50402143794288e-07 2345 1793.63636363636 1738 2.20224994891973e-08 340 2.90589618272148 3.6693450284165 1 19.7900657780553 2342 923 1169 1738 2456 3023 3489 340 1697 1921 632 1497 M12558 GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SHORT_CHAIN_FATTY_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acids with a chain length of less than C6. 18/26 Gene Ontology BP GO:0046459 1.00021418017263e-07 2.57982072081111e-07 320 1941.09090909091 1738 9.09285659678771e-09 185 1.07758210843717 -1.11360540923793 -1 7.5489636792765 316 3491 3550 2927 1738 497 185 600 3321 3787 940 1498 M11669 GO_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_MEDIATED_TRANSPORT.html A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. 1236/1788 Gene Ontology BP GO:0016192 2.02089326941243e-08 1.97691467186943e-07 2495 2046 1739 2.02089328779047e-09 179 1.92307726160109 -1.6847235390532 -1 13.8007141417114 2494 1157 4319 1675 179 1251 2400 3415 1739 1576 2301 1499 M15930 GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. 16/22 Gene Ontology BP GO:0042069 2.42247467706695e-07 4.50402143794288e-07 2345 1791.45454545455 1739 2.20224994891973e-08 301 2.90589618272148 3.6693450284165 1 19.7900657780553 2343 924 1170 1739 2457 3024 3490 301 1698 1927 633 1500 M12025 GO_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENTATION.html The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. 87/105 Gene Ontology BP GO:0043473 7.09445768775803e-08 2.23648452717738e-07 2695 1896.18181818182 1741 6.44950719685165e-09 1179 2.1023436398251 -1.82423460237437 -1 14.9761749220467 2695 1670 2253 1179 1384 1741 3009 1939 1295 2393 1300 1501 M13850 GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT.html Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. 8/14 Gene Ontology BP GO:0090192 6.34898044170118e-07 9.58838234184861e-07 430 1691.54545454545 1741 6.34898225563177e-08 85 3.39915185382055 3.39915185382055 1 21.9646991259937 429 2576 4454 2351 3405 353 208 85 1741 2811 194 1502 M12738 GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. 3/14 Gene Ontology BP GO:0007210 8.18779583871177e-08 2.37665714519812e-07 2670 2107.18181818182 1742 8.18779614039179e-09 2 5.12752597890555 4.33509176396581 1 36.5428955822262 2667 1131 4384 86 1623 2630 2665 4554 2 1695 1742 1503 M14175 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_MIGRATION.html Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration. 47/51 Gene Ontology BP GO:0014911 3.74625740687139e-08 1.97691467186943e-07 605 1835.72727272727 1742 3.40568860969483e-09 365 2.38045713975183 2.41879090156748 1 17.1099402884631 605 3379 1336 3088 661 1778 1742 365 3477 1709 2053 1504 M14356 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_CELL_CELL_SIGNALING.html Any cell surface receptor signaling pathway that is involved in cell-cell signaling. 45/99 Gene Ontology BP GO:1905114 7.92388278894499e-08 2.34750657031604e-07 2395 1722.72727272727 1742 7.20353006758602e-09 433 2.07915081083319 2.44970879538053 1 14.7624982873992 2394 433 1742 813 1485 1747 2295 3844 489 1272 2436 1505 M11325 GO_MATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING.html The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. 24/48 Gene Ontology BP GO:0007618 1.0228390828561e-07 2.61354764004912e-07 1465 1621.45454545455 1743 9.29853754918766e-09 573 2.17509046279639 2.36844963563886 1 15.3394674349468 1461 730 1597 2093 1756 2267 2857 573 2024 1743 735 1506 M15825 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_LOCALIZATION.html The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. 26/30 Gene Ontology BP GO:0040001 2.46070349134556e-07 4.55616925795102e-07 840 1753.09090909091 1743 2.23700342415971e-08 482 1.78455685455104 2.14927068225411 1 12.10012152875 838 1882 2540 2770 2469 1370 1743 482 1640 2463 1087 1507 M11642 GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 13/27 Gene Ontology BP GO:0034035 1.69833557943303e-07 3.55162042746153e-07 1155 1605.54545454545 1744 1.54394155503598e-08 342 2.17640285703107 -1.97524290181257 -1 15.0359344049644 1154 1033 1998 3048 2180 798 342 1744 2332 2267 765 1508 M11945 GO_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_FORMATION.html The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 24/26 Gene Ontology BP GO:0003272 2.41172534101395e-06 3.03946377920382e-06 2905 1850.09090909091 1744 2.19247998622262e-07 241 3.22997124258054 3.54397125901718 1 19.1192466684984 2901 2796 963 745 3662 2197 2437 1381 1284 1744 241 1509 M14579 GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 155/224 Gene Ontology BP GO:0050731 3.58876724123216e-08 1.97691467186943e-07 1745 1720.81818181818 1744 3.26251572706746e-09 239 2.36930404755698 2.61703754837281 1 17.029245649124 1744 1553 385 1744 616 1992 1834 2210 2663 239 3949 1510 M10230 GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that activates or increases the frequency, rate or extent of reproductive process. 51/84 Gene Ontology BP GO:2000243 7.43384151202735e-08 2.27713394045183e-07 3140 2288.54545454545 1745 6.75803796656207e-09 710 2.60209214359048 3.03889525808923 1 18.5410806497203 3138 1745 710 1526 1425 2231 1673 4533 2939 755 4499 1511 M14004 GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. 87/125 Gene Ontology BP GO:0060333 4.27199017006144e-07 6.95809772988745e-07 525 1745.54545454545 1746 3.88362818145688e-08 135 1.82103725443613 -1.70163215884293 -1 11.9883833444225 522 135 1746 2758 2818 1246 1355 2586 3446 543 2046 1512 M16512 GO_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. 8/16 Gene Ontology BP GO:0036149 4.52420788095629e-07 7.29928546119612e-07 1595 1991.81818181818 1746 4.52420880203711e-08 414 2.6697435120387 -2.91795454904957 -1 17.5684561699535 1594 1105 4628 2722 2906 1433 414 1746 2260 2144 958 1513 M10919 GO_CHROMOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION.html Any process in which a chromosome is transported to, or maintained in, a specific location. 65/72 Gene Ontology BP GO:0050000 1.53716244398782e-07 3.31283781930307e-07 3305 1608.63636363636 1747 1.39742050126449e-08 267 1.503100041719 1.78833576218845 1 10.3983874751932 499 267 3305 3304 2106 809 407 1747 1895 2041 1315 1514 M16180 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. 130/173 Gene Ontology BP GO:0090101 1.01751972873432e-07 2.6098603439058e-07 915 1726.27272727273 1747 9.25017977995934e-09 127 1.97573184791303 2.2892945425535 1 13.9244650244606 913 3617 2113 2396 1747 298 1141 949 2860 2828 127 1515 M16232 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html The directed movement of a protein to a specific location in the plasma membrane. 116/130 Gene Ontology BP GO:0090002 4.29001473870002e-08 1.97691467186943e-07 2685 1745.81818181818 1747 3.90001347486872e-09 28 2.03261137320716 -1.67884690281964 -1 14.5932132511028 2683 28 1747 943 815 2192 2916 3251 515 2605 1509 1516 M15058 GO_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. 12/19 Gene Ontology BP GO:0046339 1.94260375463652e-08 1.97691467186943e-07 2200 1549.27272727273 1748 1.76600342889976e-09 112 3.09848691252075 -3.20578628992993 -1 22.3050155676821 2197 1045 1448 2747 112 1748 1128 1815 305 2025 2472 1517 M15083 GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 49/59 Gene Ontology BP GO:0051784 1.87903224162265e-07 3.81629725895688e-07 380 1659.36363636364 1748 1.70821127464714e-08 319 1.76990020608631 1.81524947747311 1 12.1468130701894 378 3063 3072 2898 2249 364 319 494 1748 2989 679 1518 M11530 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 28/35 Gene Ontology BP GO:0043243 1.8062028892765e-08 1.97691467186943e-07 2085 1735.18181818182 1749 1.64200264009586e-09 81 2.03007058171444 1.89427109342661 1 14.5748301650888 2084 686 2154 1362 81 1749 2282 3169 1277 3038 1205 1519 M13100 GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. 106/171 Gene Ontology BP GO:0050709 9.34211900820775e-08 2.50783780632741e-07 4155 2182.45454545455 1750 8.49283582264833e-09 90 2.31997642311049 1.88354939196197 1 16.413680847798 4154 90 1193 1150 1666 3012 2519 3312 1750 1407 3754 1520 M15987 GO_O_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_O_GLYCAN_PROCESSING.html The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. 40/65 Gene Ontology BP GO:0016266 3.19421777695698e-08 1.97691467186943e-07 3735 1943.90909090909 1751 2.90383438484944e-09 337 2.99201763032706 -3.09249395163293 -1 21.5346910534386 3733 462 337 2688 473 3111 3183 1751 1627 413 3605 1521 M14231 GO_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/57 Gene Ontology BP GO:0032371 9.1377552211934e-08 2.49206886189644e-07 3835 2292.90909090909 1752 8.30705054612034e-09 505 2.92787726508198 -1.33609311559675 -1 20.7528303789415 3835 505 915 1752 1638 4573 4313 3067 2219 1717 688 1522 M11476 GO_MALE_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_GAMETE_GENERATION.html Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. 416/832 Gene Ontology BP GO:0048232 9.86575811051036e-08 2.57032100060153e-07 1305 2368.63636363636 1753 8.9688714117581e-09 1302 1.80862914435479 1.85333043510074 1 12.7501424417713 1302 3855 3066 4113 1720 1344 1611 1397 2644 3250 1753 1523 M15298 GO_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/57 Gene Ontology BP GO:0032374 9.1377552211934e-08 2.49206886189644e-07 3840 2269.63636363636 1753 8.30705054612034e-09 506 2.92787726508198 -1.33609311559675 -1 20.7528303789415 3836 506 916 1753 1639 4574 4314 2801 2220 1718 689 1524 M11391 GO_POSITIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BEHAVIOR.html Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 14/31 Gene Ontology BP GO:0048520 1.02097176242592e-06 1.42874634904296e-06 595 1696.90909090909 1754 9.28156578397128e-08 455 3.03119251913065 3.03119251913065 1 19.0081388746987 595 2910 1754 2422 3288 1566 1017 613 2095 1951 455 1525 M12535 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. 47/88 Gene Ontology BP GO:0032735 9.26431929054717e-07 1.32108114186074e-06 165 1794.54545454545 1754 8.4221119925496e-08 162 1.45933307605201 -1.60258166660334 -1 9.14619259552167 162 1754 2854 2892 3232 275 425 772 3979 2517 878 1526 M10638 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. 221/330 Gene Ontology BP GO:0050688 4.2501330212811e-07 6.93308123521039e-07 645 1815.63636363636 1756 3.86375803850495e-08 643 1.99306660008222 -1.72472832197164 -1 13.1349480240142 643 2157 1565 3032 2814 753 1018 1756 2864 2385 985 1527 M10799 GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. 60/65 Gene Ontology BP GO:1901185 2.54644185036559e-08 1.97691467186943e-07 1680 2323.36363636364 1756 2.31494716349089e-09 276 1.52654966337392 -1.40957776824013 -1 10.931765246829 1676 3050 3491 3745 276 1554 1698 1602 2852 3857 1756 1528 M15667 GO_MECHANOSENSORY_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MECHANOSENSORY_BEHAVIOR.html Behavior that is dependent upon the sensation of a mechanical stimulus. 13/22 Gene Ontology BP GO:0007638 2.21280736289914e-08 1.97691467186943e-07 3320 1965.72727272727 1756 2.01164307741457e-09 156 2.83488217116219 2.83818888135756 1 20.3977875845919 3319 979 1237 156 177 3211 3499 3800 333 1756 3156 1529 M14403 GO_POTASSIUM_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POTASSIUM_ION_IMPORT.html The directed movement of potassium ions into a cell or organelle. 19/35 Gene Ontology BP GO:0010107 2.16907565581091e-07 4.18784606908222e-07 2295 1828.63636363636 1757 1.97188715424503e-08 700 2.97126828279002 2.2268145243231 1 20.3391771157691 2295 833 769 700 2369 1757 2658 2420 1354 1021 3939 1530 M11712 GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPIDERMAL_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. 59/69 Gene Ontology BP GO:0070849 1.02526085797046e-07 2.6154269584082e-07 2260 1715.63636363636 1758 9.32055368864048e-09 300 2.66861360771289 2.99837720745299 1 18.8447207027342 2257 300 645 639 1758 1868 2861 3090 545 1288 3621 1531 M14546 GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of activated T cell proliferation. 16/28 Gene Ontology BP GO:0042104 3.89849223992301e-07 6.51569123288857e-07 1965 1723 1759 3.54408448250213e-08 937 2.21051741618655 -1.90924661352989 -1 14.6446892156937 1964 2007 1759 1339 2749 1557 937 1799 2533 1157 1152 1532 M12735 GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is divided into specific regions along the rostrocaudal axis. 13/21 Gene Ontology BP GO:0021903 9.36007548158513e-08 2.50783780632741e-07 2110 1798.27272727273 1760 8.50915989074274e-09 77 2.24132150764178 2.61910265377263 1 15.8533680983911 2108 2017 2274 1435 1670 1760 879 4626 77 2792 143 1533 M13232 GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION_MEDIATED_BY_INTEGRIN.html Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin. 47/68 Gene Ontology BP GO:0033628 2.72412089096392e-08 1.97691467186943e-07 4320 2522.18181818182 1760 2.47647356790452e-09 330 2.3949958081126 2.56239649355087 1 17.2151301837268 4318 1760 1006 1222 330 4463 4543 3975 1359 768 4000 1534 M16719 GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 46/72 Gene Ontology BP GO:0060119 5.34403173038367e-08 2.05087954115883e-07 2620 1808 1761 4.85821078199622e-09 441 2.21452098118106 2.49400016612954 1 15.8712366492771 2618 448 1761 2144 1088 2495 3206 2560 1746 1381 441 1535 M16851 GO_ESTROUS_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROUS_CYCLE.html A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. 16/25 Gene Ontology BP GO:0044849 1.03125888083957e-07 2.62523462891997e-07 4280 2339.09090909091 1761 9.37508117436596e-09 963 2.70514107346168 -2.47385521802223 -1 19.0994659588148 4280 1996 1503 1575 1761 3734 3470 1737 963 1513 3198 1536 M10333 GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. 41/51 Gene Ontology BP GO:0031109 1.8192719405628e-06 2.3559900749899e-06 1130 2184.09090909091 1763 1.65388494999685e-07 966 1.60729316110868 1.72453605203071 1 9.64916310409025 1763 3075 3397 2777 3562 1560 1013 966 1126 3657 1129 1537 M15026 GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 1034/1522 Gene Ontology BP GO:0071495 2.53217649318349e-08 1.97691467186943e-07 1870 1738.81818181818 1763 2.53217652203712e-09 315 2.17655032075266 2.39896092689725 1 15.6346375714716 1867 1173 4531 437 351 1159 2193 2821 1763 315 2517 1538 M11401 GO_CLATHRIN_COAT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_COAT_ASSEMBLY.html The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. 11/13 Gene Ontology BP GO:0048268 5.78116922784966e-07 8.89751581314237e-07 1005 1879.09090909091 1766 5.25560977002573e-08 190 1.62820054387073 -1.43657129408561 -1 10.5192792031451 1002 2055 3004 3299 2985 765 190 1766 1187 2896 1521 1539 M15027 GO_SCHWANN_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DEVELOPMENT.html The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 32/34 Gene Ontology BP GO:0014044 1.03884358388857e-07 2.63663509078223e-07 1110 1899.72727272727 1766 9.4440330267539e-09 749 1.63760171493707 1.94110208191318 1 11.5142182528885 1108 1836 2741 2534 1766 1135 756 1497 3602 3173 749 1540 M11800 GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. 1274/1619 Gene Ontology BP GO:0051130 4.54421344101784e-08 1.97760774550163e-07 1575 1799.45454545455 1767 4.54421353394228e-09 552 2.08412657029333 2.26207248382602 1 14.9655926161888 1571 1159 4324 552 1010 1767 2264 2024 1936 771 2416 1541 M15686 GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. 38/69 Gene Ontology BP GO:0002711 1.06301225236737e-06 1.47868341114061e-06 415 2018.54545454545 1768 9.66375241819841e-08 411 1.35058052040104 -1.327534331072 -1 8.38482817599323 411 487 2900 3087 3309 646 1362 2753 4196 1768 1285 1542 M12545 GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. 46/62 Gene Ontology BP GO:1903523 3.43788656670882e-08 1.97691467186943e-07 4635 2414.90909090909 1771 3.12535147311986e-09 560 2.3114929257278 -2.69727839123814 -1 16.6109717261354 4634 1771 1328 1539 560 4214 4529 1253 2301 1380 3055 1543 M10285 GO_AMMONIUM_ION_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_ION_METABOLIC_PROCESS.html The chemical reactions and pathways involving the ammonium ion. 145/208 Gene Ontology BP GO:0097164 2.56761557179433e-08 1.97691467186943e-07 1725 1858.09090909091 1772 2.33419600160083e-09 280 2.08984188819482 -1.99188904430014 -1 15.0072863785762 1722 2627 1314 3591 280 885 1772 1613 2289 2420 1926 1544 M15197 GO_GLYCEROLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. 28/46 Gene Ontology BP GO:0046503 7.60654099113345e-08 2.29469567498056e-07 1775 1971.81818181818 1773 6.91503750375549e-09 690 2.30147392772923 -2.02053015670945 -1 16.3776867780694 1773 690 1549 4081 1447 2089 2572 2492 2936 1111 950 1545 M15736 GO_HEXOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 174/228 Gene Ontology BP GO:0019318 2.6897327627856e-08 1.97691467186943e-07 1775 1829.90909090909 1774 2.44521163242767e-09 318 1.74139967436339 -1.59395749384654 -1 12.4862439372141 1774 2176 2775 2493 318 1329 1728 1733 2052 1456 2295 1546 M16164 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. 31/60 Gene Ontology BP GO:0002717 2.83529588437046e-07 5.07799528482515e-07 355 1626.90909090909 1774 2.57754204525017e-08 223 1.52037890419481 -1.31020995517405 -1 10.2148590541835 355 620 2619 2368 2555 320 223 1967 4195 1774 900 1547 M10120 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. 115/144 Gene Ontology BP GO:0031333 1.0502372158102e-07 2.64657043934525e-07 4085 2318.36363636364 1775 9.54761150860441e-09 260 2.11506609626129 -2.0667899814147 -1 14.900587046171 4083 1612 1683 589 1775 4417 4504 3302 260 2875 402 1548 M10948 GO_ROUNDABOUT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ROUNDABOUT_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 11/15 Gene Ontology BP GO:0035385 1.44950173985689e-06 1.93474801937869e-06 720 1627.63636363636 1776 1.31772972262082e-07 363 3.14725200839126 3.86161756448916 1 19.2930306505377 717 2036 1290 1911 3457 1585 1967 363 469 2333 1776 1549 M11863 GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction. 44/49 Gene Ontology BP GO:0051058 9.91475475216874e-08 2.5758433200358e-07 1330 1963.54545454545 1776 9.01341381727065e-09 1327 2.14685249277513 2.12070106759993 1 15.1534777421595 1327 2314 2339 2375 1726 1365 1403 1776 2709 2751 1514 1550 M14124 GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. 30/30 Gene Ontology BP GO:0032469 2.29822634510534e-08 1.97691467186943e-07 1780 2058.72727272727 1777 2.0892966991943e-09 193 1.30808556111128 -1.35713656915316 -1 9.3511379523858 1777 646 3231 3906 193 1222 980 2295 3681 2971 1744 1551 M11039 GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of vasculature development. 141/200 Gene Ontology BP GO:1904018 1.0521544095539e-07 2.64711738989803e-07 765 1897.81818181818 1778 9.56504054430362e-09 668 2.47439060156285 2.56300641225138 1 17.4509933717279 763 3334 668 2129 1778 1440 1548 3019 2911 825 2461 1552 M12612 GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. 31/40 Gene Ontology BP GO:0045822 9.43556097334307e-08 2.5159693529493e-07 1950 1804.27272727273 1778 8.57778307093098e-09 332 2.20448998266205 -2.58019379881818 -1 15.5876471020198 1949 2362 1778 1190 1679 2391 2385 332 2696 1476 1609 1553 M15200 GO_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. 80/124 Gene Ontology BP GO:0019218 8.52897068910939e-08 2.43169734169277e-07 1775 1864.63636363636 1779 7.75361001796453e-09 1240 2.45042954140716 -1.91565502474726 -1 17.378398354782 1771 2661 1240 2294 1560 1847 1797 1310 1779 2478 1774 1554 M10208 GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DIFFERENTIATION.html The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. 17/25 Gene Ontology BP GO:0021889 1.45035573980645e-07 3.19514520834882e-07 3930 2079.45454545455 1780 1.31850530492867e-08 285 3.21415740847126 -2.38004471201699 -1 22.4186543065194 3928 865 804 285 2057 3856 4351 4079 298 571 1780 1555 M14999 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. 45/62 Gene Ontology BP GO:2000649 1.4274075810803e-07 3.16574236166189e-07 3045 1860.72727272727 1780 1.29764333972145e-08 272 1.96613931748647 -1.94261144157999 -1 13.678369598598 3043 427 1780 1532 2042 3073 3745 272 2317 656 1581 1556 M10383 GO_EPIDERMIS_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMIS_MORPHOGENESIS.html The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. 39/52 Gene Ontology BP GO:0048730 1.67912144958426e-06 2.19711813974004e-06 1450 2054.36363636364 1782 1.52647521013935e-07 687 3.50877020527669 4.03106411179615 1 21.3130318543085 1448 2729 687 1795 3525 1422 1782 2483 3629 1624 1474 1557 M11707 GO_INSEMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSEMINATION.html The introduction of semen or sperm into the genital tract of a female. 9/18 Gene Ontology BP GO:0007320 1.18342238896154e-07 2.83546054368591e-07 1340 1980 1782 1.18342245198353e-08 466 2.91646411147902 3.24510767232069 1 20.4950306177392 1336 1106 4321 2502 1964 1782 2497 466 3872 1260 674 1558 M11224 GO_CEREBELLAR_CORTEX_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_MORPHOGENESIS.html The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 38/57 Gene Ontology BP GO:0021696 4.20219887903863e-08 1.97691467186943e-07 2570 1622.18181818182 1783 3.82018087209494e-09 103 3.02328328907168 3.1186259407783 1 21.7609037496145 2568 1783 743 103 790 2669 2512 3381 257 1243 1795 1559 M12590 GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a type 2 immune response. 11/18 Gene Ontology BP GO:0002830 1.48485698710454e-07 3.24978342474009e-07 1560 1765.18181818182 1783 1.34987007938431e-08 681 2.93550029097404 -3.59118762685332 -1 20.4418946228568 1556 2543 1444 799 2073 2320 3521 907 681 1783 1790 1560 M13946 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. 12/13 Gene Ontology BP GO:0040015 1.46276430390227e-07 3.218081468585e-07 2070 1771 1783 1.32978581923676e-08 706 2.66593886412534 -2.73962181938022 -1 18.5666178451449 2069 1037 1783 1936 2062 1704 2612 1237 706 3072 1263 1561 M16320 GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_IMPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 21/23 Gene Ontology BP GO:0046325 3.30786897471879e-07 5.70901867187186e-07 2560 2068.36363636364 1783 3.00715406552945e-08 810 2.22658529140312 -1.63601775545958 -1 14.8898909876611 2558 810 1717 851 2653 3970 3900 1028 1480 2002 1783 1562 M16308 GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_MAMMARY_GLAND_DUCT_MORPHOGENESIS.html The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 40/46 Gene Ontology BP GO:0060444 5.23354591722799e-07 8.20198354761261e-07 2545 1805.27272727273 1784 4.75777014748049e-08 161 3.01162539800726 3.25050451488305 1 19.6681322675867 2543 2324 970 236 2936 1784 2225 3446 161 1468 1765 1563 M10116 GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEPATOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of hepatocyte proliferation. 11/16 Gene Ontology BP GO:2000345 1.49972441851233e-06 1.99257533575237e-06 2975 2121.54545454545 1785 1.36338676442256e-07 763 2.37963260865945 -2.50482079329328 -1 14.5269995485254 2974 1050 1664 1538 3470 3920 2999 1785 763 1300 1874 1564 M10951 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html The directed movement of a protein to a specific location. 1474/1849 Gene Ontology BP GO:0045184 3.01150122494692e-08 1.97691467186943e-07 1455 2372.09090909091 1785 3.01150126575805e-09 526 1.56912052058108 -1.4207319016127 -1 11.2397730987029 1453 3581 4270 4277 526 679 1785 1380 2549 4556 1037 1565 M11102 GO_PENTOSE_PHOSPHATE_SHUNT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PENTOSE_PHOSPHATE_SHUNT.html The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. 15/16 Gene Ontology BP GO:0006098 2.11930566173757e-06 2.70687050344905e-06 335 1710.09090909091 1785 1.92664336664677e-07 325 1.66660157485507 -1.52824366067251 -1 9.90093847448178 331 2492 2754 2748 3612 595 325 348 1785 2690 1131 1566 M11657 GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 77/129 Gene Ontology BP GO:0045428 1.8901551929977e-07 3.82687561421743e-07 4050 2121.36363636364 1787 1.71832305035688e-08 201 2.09619671426605 -2.41694875528438 -1 14.4043147232426 4050 201 1138 854 2257 4496 3789 1545 2565 653 1787 1567 M11681 GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 412/516 Gene Ontology BP GO:0090407 2.92370737017285e-08 1.97691467186943e-07 915 2041.27272727273 1787 2.6579158263888e-09 393 1.61518322387835 -1.55577632961826 -1 11.5730450886245 912 2130 3660 4351 393 789 1305 1787 2025 3429 1673 1568 M14318 GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. 106/121 Gene Ontology BP GO:0032231 3.27482395354768e-08 1.97691467186943e-07 1790 1628.18181818182 1788 2.97711272935935e-09 76 2.04607909390768 2.33786492796335 1 14.6906546463376 1788 76 1636 630 509 1929 2710 3053 2000 1899 1680 1569 M14022 GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_PERMEABILITY.html Any process that increases the extent to which blood vessels can be pervaded by fluid. 8/13 Gene Ontology BP GO:0043117 3.28659372576469e-07 5.68283931846269e-07 1600 1930.09090909091 1789 3.28659421184121e-08 259 2.20223885352633 2.54535726850736 1 14.730586029782 1596 2577 4466 1789 2703 1453 931 259 2312 2140 1005 1570 M11437 GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. 27/44 Gene Ontology BP GO:0045920 2.84425324504417e-07 5.09207785655657e-07 1510 1768.09090909091 1792 2.58568510251032e-08 465 1.82576841925836 -1.91851362260047 -1 12.2870047026109 1506 1883 2737 1257 2557 1832 1792 603 465 3528 1289 1571 M10827 GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process. 77/123 Gene Ontology BP GO:1903428 1.06749105251438e-07 2.66423092468559e-07 3190 1976.45454545455 1793 9.70446458465021e-09 207 2.04594317425472 -2.28428168095614 -1 14.4035439054531 3189 207 1241 312 1793 3825 4427 1461 2364 1088 1834 1572 M11094 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION_EMBRYO.html The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. 11/18 Gene Ontology BP GO:0008595 4.72756032303101e-07 7.56399145028913e-07 3290 1964.81818181818 1793 4.2977830353932e-08 158 2.92687315267063 3.00333553994619 1 19.2225422385154 3288 1051 1166 218 2873 2851 1793 4525 158 1303 2387 1573 M12466 GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION.html Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix. 45/50 Gene Ontology BP GO:0001953 2.37244926049382e-07 4.43333590726014e-07 1185 2085.36363636364 1794 2.1567722875777e-08 1116 2.56553430946681 2.75083351693476 1 17.4778687706022 1587 3674 1794 2406 2443 1182 1452 1116 3522 2578 1185 1574 M14898 GO_TRIPARTITE_REGIONAL_SUBDIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIPARTITE_REGIONAL_SUBDIVISION.html Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. 11/18 Gene Ontology BP GO:0007351 4.72756032303101e-07 7.56399145028913e-07 3290 1966.27272727273 1794 4.2977830353932e-08 159 2.92687315267063 3.00333553994619 1 19.2225422385154 3289 1052 1167 219 2874 2852 1794 4526 159 1309 2388 1575 M11556 GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CORTICOSTEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. 10/20 Gene Ontology BP GO:2000846 2.42766019356385e-07 4.51114332294433e-07 1345 1906.90909090909 1795 2.20696405586527e-08 500 2.5073988674372 -2.82153522329169 -1 17.0588075086697 1341 3262 1795 2820 2460 1706 510 500 3234 2075 1273 1576 M15225 GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of MAP kinase activity. 249/335 Gene Ontology BP GO:0043406 5.21791811408146e-08 2.03844518708446e-07 2790 1968.09090909091 1795 4.74356203439915e-09 635 2.23282945258184 2.391832584885 1 16.0097509495746 2787 1413 635 1051 1057 1839 2285 3946 1795 861 3980 1577 M14454 GO_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_POTENTIATION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. 43/63 Gene Ontology BP GO:0060291 2.50296091138839e-07 4.6171597062325e-07 1885 1502 1796 2.27541926922971e-08 267 2.79903934167631 3.27035469108366 1 19.0256306750391 1881 473 1177 267 2476 1820 1767 2440 480 1796 1945 1578 M16752 GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_TRANSPORT.html Any process that modulates the frequency, rate or extent of synaptic vesicle transport. 46/58 Gene Ontology BP GO:1902803 2.00376052548302e-07 3.97760141854629e-07 2210 1751 1796 1.82160064362327e-08 405 1.62651679680379 -1.40739042888051 -1 11.1220511826044 2210 405 2686 1956 2303 1005 1100 1707 1796 2419 1674 1579 M13777 GO_LONG_TERM_MEMORY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_MEMORY.html The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. 32/45 Gene Ontology BP GO:0007616 7.92906323606162e-07 1.15473963184334e-06 1800 1895.54545454545 1797 7.20824190344757e-08 444 3.20800672976094 3.85225342542973 1 20.4436622060436 1797 3105 1368 1745 3161 1939 2112 1013 444 2889 1278 1580 M10567 GO_RESPONSE_TO_AMINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. 51/77 Gene Ontology BP GO:0014075 5.07284745552705e-08 2.02998167617902e-07 1865 1664.72727272727 1799 4.61167961136253e-09 393 2.13210397777725 2.09733051576134 1 15.2865887043454 1864 393 1799 1014 1022 1940 2522 1120 713 3143 2782 1581 M14597 GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_PROCESS.html A biological process that directly contributes to the process of producing new individuals, involving another organism. 781/1478 Gene Ontology BP GO:0044703 3.98105449111679e-08 1.97691467186943e-07 1375 1914.63636363636 1799 3.98105456243637e-09 838 2.12608952424292 2.17396122219497 1 15.2695445816552 1372 2593 4502 1833 838 1268 1799 1572 1950 1079 2255 1582 M16239 GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. 636/1026 Gene Ontology BP GO:0045596 7.90101851712608e-11 1.81997223565285e-09 2285 1707.81818181818 1799 7.90101851740698e-12 94 2.34362915907067 2.6425587499557 1 21.9929810321493 2281 1226 4607 428 401 1799 2290 1550 1846 94 2264 1583 M16880 GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of actin depolymerization. 17/21 Gene Ontology BP GO:0030836 5.98122337079261e-08 2.09283415644357e-07 1635 1943.36363636364 1799 5.43747593946036e-09 1201 2.18555746557965 1.71317859868702 1 15.6414348490061 1634 2849 2102 1731 1217 1201 1487 2170 1799 3025 2162 1584 M10221 GO_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 155/226 Gene Ontology BP GO:0045471 1.07388105104747e-07 2.67349841119521e-07 3595 2060.54545454545 1800 9.76255548605985e-09 106 2.70735788505572 3.00530423793472 1 19.0920930529208 3592 1545 284 106 1800 3912 4120 2605 907 414 3381 1585 M12632 GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENZYME_LINKED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. 690/914 Gene Ontology BP GO:0007167 2.02198136955154e-08 1.97691467186943e-07 2100 1871.27272727273 1800 2.02198138794938e-09 180 2.08987381436234 2.37661241698915 1 15.0075173701727 2100 1220 4380 449 180 1584 2489 2707 1800 565 3110 1586 M14470 GO_LYMPH_VESSEL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_VESSEL_MORPHOGENESIS.html The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. 15/17 Gene Ontology BP GO:0036303 5.24705578541704e-05 5.63586116563839e-05 2475 1790 1800 4.77016448473343e-06 401 3.20343174236683 3.04690713868672 1 14.5768709921066 2474 2889 1800 764 4316 1895 793 710 401 2694 954 1587 M15776 GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_RADIALLY_ORIENTED_CELL_MIGRATION.html The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. 26/35 Gene Ontology BP GO:0021799 4.10815454408332e-07 6.7712515386538e-07 1300 1799.45454545455 1800 3.73468664656079e-08 268 1.58696299755154 2.02858897078101 1 10.4531182322088 1299 1892 2816 1800 2786 1678 1920 384 268 3421 1530 1588 M15035 GO_NEUROTRANSMITTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 23/41 Gene Ontology BP GO:0042133 1.76517142560479e-08 1.97691467186943e-07 3915 2081.81818181818 1801 1.60470130887969e-09 73 3.48713863389103 -2.54694544556392 -1 25.1169810689601 3914 2415 902 1327 73 4487 3872 1801 1882 1615 612 1589 M12634 GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). 30/46 Gene Ontology BP GO:0007205 1.65154311845189e-07 3.48135215849875e-07 1825 1553.45454545455 1802 1.5014029476668e-08 249 2.44727449882961 2.74367903808062 1 16.9442805467191 1822 628 1515 1165 2159 2301 2730 1802 249 1933 784 1590 M12614 GO_SULFUR_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 35/44 Gene Ontology BP GO:0044273 1.08113054284918e-07 2.68150341997721e-07 1125 1774.72727272727 1806 9.82845996344023e-09 714 2.55724822121737 2.80661892537781 1 18.023676317621 1125 1805 1412 1127 1806 2300 2683 2097 714 2304 2149 1591 M12066 GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUESTERING_OF_TRIGLYCERIDE.html Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. 13/16 Gene Ontology BP GO:0010889 1.08321118255219e-07 2.68523262249087e-07 780 1658 1807 9.84737487169207e-09 27 2.45524889050974 -2.43638722284497 -1 17.2986670660219 778 2904 2190 2485 1807 1265 2136 638 1740 2268 27 1592 M12182 GO_BIOTIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BIOTIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. 12/13 Gene Ontology BP GO:0006768 1.30467665940585e-05 1.48222905220172e-05 1560 2360.36363636364 1807 1.18607672423391e-06 329 2.28601644109413 -1.57591930099376 -1 11.8009346733025 1560 3820 2639 3672 4551 1438 1127 329 1526 3495 1807 1593 M14245 GO_SMALL_MOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. 313/427 Gene Ontology BP GO:0044282 2.81321508794702e-08 1.97691467186943e-07 1015 1705.54545454545 1807 2.55746829447324e-09 354 1.8529954413757 -1.77698775012662 -1 13.2936594963705 1015 1356 1935 3019 354 1146 1807 1277 1991 2754 2107 1594 M14968 GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a humoral immune response. 38/65 Gene Ontology BP GO:0002920 7.72801593044637e-08 2.30947065667097e-07 1810 2301.18181818182 1807 7.02546927446459e-09 701 2.2824069087389 -2.58183970543725 -1 16.2341996600015 1807 2342 1275 4096 1467 2659 3754 1452 3994 1766 701 1595 M10367 GO_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACID_SECRETION.html The controlled release of acid by a cell or a tissue. 64/113 Gene Ontology BP GO:0046717 1.08545638305304e-07 2.6865217663753e-07 4405 2247.90909090909 1809 9.86778578734815e-09 264 2.99530723451758 3.35105986065992 1 21.1278977529719 4404 264 442 912 1809 4024 4061 2779 904 661 4467 1596 M11653 GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_POLYMERIZATION_OR_DEPOLYMERIZATION.html Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. 41/52 Gene Ontology BP GO:0008154 1.54155556375218e-08 1.97691467186943e-07 4505 2100.27272727273 1809 1.40141415868542e-09 38 2.07945574127594 1.70461837273596 1 14.9321407270295 4501 1766 1787 1137 38 3621 2897 1809 307 2118 3122 1597 M12995 GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of cell junction assembly. 44/50 Gene Ontology BP GO:1901890 3.77792533836996e-07 6.35757200702908e-07 1010 1689 1810 3.43447817011828e-08 403 2.58177684690099 3.02964779051516 1 17.1530077440832 1006 403 528 1031 2730 1810 2006 3185 2535 713 2632 1598 M11198 GO_HEXOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule. 13/22 Gene Ontology BP GO:0035428 1.05722401051647e-06 1.47151161260339e-06 4540 2081.36363636364 1811 9.61113198702307e-08 114 3.49663984299735 -3.50103745063941 -1 21.8959179442155 4540 963 633 684 3304 4092 3677 1811 114 693 2384 1599 M13761 GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell. 36/55 Gene Ontology BP GO:0042491 5.31264516045794e-07 8.28687158283969e-07 4435 2372.72727272727 1811 4.82967858488772e-08 880 2.45006653094818 2.25914409025251 1 15.9678265375133 4435 1810 1596 1388 2947 3926 3308 1512 880 1811 2487 1600 M13887 GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 36/43 Gene Ontology BP GO:0010800 6.86029771801526e-08 2.20507296091218e-07 2590 1720.09090909091 1812 6.23663448358282e-09 557 2.12158495287261 -1.9503548828856 -1 15.1283420720859 2590 557 1611 1049 1353 1917 1891 2907 600 1812 2634 1601 M10848 GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. 64/98 Gene Ontology BP GO:2000737 1.09017126931991e-07 2.69381577639745e-07 3085 2088.81818181818 1813 9.910648394013e-09 272 2.13498375543978 2.2829284034742 1 15.0242654693477 3082 272 1099 1230 1813 2768 2432 3571 1453 1002 4255 1602 M13299 GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. 17/26 Gene Ontology BP GO:0006688 5.28254093940433e-07 8.26207159362969e-07 3150 2050.81818181818 1813 4.80231109802245e-08 900 2.47260297675701 2.63627353354584 1 16.1192171755182 3149 900 1286 2236 2940 3420 2692 1606 1813 1317 1200 1603 M13598 GO_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_INTERNALIZATION.html A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. 51/81 Gene Ontology BP GO:0031623 5.28932010537044e-08 2.04581932255101e-07 1815 1893.81818181818 1813 4.8084729386711e-09 1077 1.98237318572278 2.0512086520617 1 14.1978974046481 1813 1746 1826 1202 1077 1795 2256 2959 1818 1410 2930 1604 M15931 GO_MELANOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MELANOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. 25/30 Gene Ontology BP GO:0030318 3.31296242529504e-07 5.71568934553126e-07 4605 2186.81818181818 1813 3.01178447653774e-08 133 3.28040759803647 -3.03804333679467 -1 21.9888718307438 4603 700 807 133 2654 4342 4490 1813 891 1018 2604 1605 M13837 GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 111/138 Gene Ontology BP GO:0033209 3.65691120716669e-08 1.97691467186943e-07 825 2041.63636363636 1815 3.32446478904823e-09 638 2.04374903700856 -1.89999754919738 -1 14.6737962632247 822 3626 3020 2178 638 1331 1413 2686 1815 3654 1275 1606 M16809 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION.html Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. 21/36 Gene Ontology BP GO:0010575 6.0756551717109e-08 2.10655912920796e-07 1990 1983 1815 5.52332303590903e-09 770 2.38378758112672 2.08084506300059 1 17.0630679704856 1990 1954 1208 1551 1229 1815 770 3545 2726 1641 3384 1607 M13357 GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_THYROID_HORMONE_STIMULUS.html A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. 18/28 Gene Ontology BP GO:0097067 3.26827811304231e-08 1.97691467186943e-07 1820 1684.81818181818 1816 2.97116196508657e-09 451 3.30125741238702 -3.54995367240155 -1 23.772096810216 1816 2448 1381 1726 503 2656 2811 978 451 1891 1872 1608 M10691 GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_TO_EPITHELIAL_TRANSITION.html A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. 9/20 Gene Ontology BP GO:0060231 6.48344342429955e-07 9.76293276804719e-07 4235 2310.81818181818 1817 6.48344531587705e-08 8 3.24125833165961 -4.41239424662108 -1 20.9117593019585 4234 1070 4255 82 3098 4385 3928 1154 8 1817 1388 1609 M16598 GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 29/39 Gene Ontology BP GO:0010922 3.15861689535326e-08 1.97691467186943e-07 1245 1841.90909090909 1817 2.87146994609329e-09 463 1.8368009632666 2.28106105589107 1 13.1764895180839 1245 2372 2505 2858 463 1473 932 1817 3789 1832 975 1610 M11468 GO_FORELIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORELIMB_MORPHOGENESIS.html The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. 34/58 Gene Ontology BP GO:0035136 5.12165927700758e-07 8.05376161403051e-07 1970 1882.27272727273 1819 4.65605497213095e-08 432 2.82770286538553 2.83081807928681 1 18.4842458807241 1967 2341 986 1869 2925 1430 1038 4606 1819 1292 432 1611 M13957 GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_TRANSMEMBRANE_TRANSPORT.html The directed movement of glucose across a membrane. 13/22 Gene Ontology BP GO:1904659 1.05722401051647e-06 1.47151161260339e-06 4545 2083.09090909091 1819 9.61113198702307e-08 115 3.49663984299735 -3.50103745063941 -1 21.8959179442155 4541 964 634 685 3305 4093 3678 1819 115 695 2385 1612 M16582 GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 1235/1720 Gene Ontology BP GO:0010648 4.63571744864736e-08 1.97760774550163e-07 1820 1787.54545454545 1819 4.6357175453518e-09 381 2.07784747856828 2.36337306127242 1 14.9201632834302 1819 1161 4637 915 1030 1130 2259 2131 1998 381 2202 1613 M11860 GO_PEPTIDYL_PROLINE_HYDROXYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_HYDROXYLATION.html The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. 11/13 Gene Ontology BP GO:0019511 8.9127326985219e-07 1.27878338717923e-06 855 1866.54545454545 1821 8.10248755389798e-08 99 2.62670561479758 2.78985668327293 1 16.5930920556468 854 2938 2147 1501 4189 1821 3294 99 1075 2336 278 1614 M16241 GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_PEROXISOME_MATRIX.html The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. 13/13 Gene Ontology BP GO:0016558 1.0708739699812e-05 1.22457030777157e-05 905 2147.09090909091 1821 9.73526529647677e-07 76 1.08943328573778 -0.689940634328978 -1 5.66220887955658 902 3222 3453 3178 4414 751 76 299 1821 4136 1366 1615 M10687 GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. 40/54 Gene Ontology BP GO:0045599 1.79738584146717e-08 1.97691467186943e-07 2505 1727.63636363636 1822 1.63398714195609e-09 78 2.36926069391142 2.64621626991411 1 17.0289319776568 2505 2326 1397 1189 78 1699 842 2298 1822 1979 2869 1616 M13776 GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_PLASMA_MEMBRANE_PROTEIN_TRANSPORT.html The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. 37/41 Gene Ontology BP GO:0043001 2.33381862563933e-07 4.40716642252427e-07 1540 2023.72727272727 1822 2.12165352110642e-08 590 1.40356577733225 -1.60060709522152 -1 9.51455397867742 1539 1822 3519 2371 2419 1578 2332 645 590 3942 1504 1617 M16095 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport. 26/46 Gene Ontology BP GO:1903170 2.41196794392228e-08 1.97691467186943e-07 1810 1854.45454545455 1823 2.19269815487806e-09 236 1.77156861234762 1.89732528482324 1 12.7045216603199 1806 745 2543 2828 236 1796 1752 1962 2085 2823 1823 1618 M16234 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 449/537 Gene Ontology BP GO:0010639 2.01842059264016e-07 3.99633168316993e-07 1245 2067.36363636364 1823 1.83492797983908e-08 1011 1.71557826607874 1.85995843108622 1 11.7334648487201 1242 2981 3366 1908 2309 1011 1335 1563 1823 3536 1667 1619 M10306 GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_PROCESSING.html Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. 36/62 Gene Ontology BP GO:0010955 4.47150513111611e-08 1.97691467186943e-07 3730 2449.63636363636 1824 4.06500474727232e-09 880 3.08478254719686 -2.96317390205804 -1 22.2058620057943 3729 1824 937 1872 880 4530 4568 3386 1620 1808 1792 1620 M16139 GO_RENAL_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_FILTRATION.html A renal system process in which fluid circulating through the body is filtered through a barrier system. 9/13 Gene Ontology BP GO:0097205 1.02419744464895e-07 2.61489763053712e-07 1880 1658.09090909091 1824 1.02419749185307e-08 350 2.20922308108487 2.61419320779218 1 15.5814221723575 1879 1074 4596 1853 1843 2390 1346 382 350 1824 702 1621 M16220 GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MATURATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. 36/62 Gene Ontology BP GO:1903318 4.47150513111611e-08 1.97691467186943e-07 3730 2436.81818181818 1825 4.06500474727232e-09 881 3.08478254719686 -2.96317390205804 -1 22.2058620057943 3730 1825 938 1873 881 4531 4569 3230 1621 1814 1793 1622 M15089 GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. 137/213 Gene Ontology BP GO:0045834 1.10736623292723e-07 2.71799508392894e-07 2600 1900.27272727273 1826 1.0066966260603e-08 281 2.22170902086393 -1.9524909911739 -1 15.6298558555762 2600 2629 1171 281 1826 2073 3735 2078 1806 1224 1480 1623 M10624 GO_RESPONSE_TO_STEROID_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROID_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 534/831 Gene Ontology BP GO:0048545 3.40356758039958e-08 1.97691467186943e-07 1830 1773.36363636364 1827 3.40356763252881e-09 94 2.37099610669084 2.3355104166763 1 17.0414880030077 1827 1257 4252 94 660 933 2399 3215 2037 439 2394 1624 M10640 GO_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 440/596 Gene Ontology BP GO:1901652 3.59182175618525e-08 1.97691467186943e-07 4400 2576.27272727273 1828 3.26529255893363e-09 205 2.08982521522248 -1.79671250336349 -1 15.0071657466056 4399 1301 699 205 618 4547 4048 4608 1828 1586 4500 1625 M11625 GO_REGULATION_OF_POSITIVE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSITIVE_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. 29/34 Gene Ontology BP GO:0050926 1.47127189591932e-07 3.23068812256375e-07 1175 1731.63636363636 1828 1.33751999482918e-08 778 2.97780091646953 3.06625861872554 1 20.7463177127458 1172 2376 1082 1200 2066 1493 778 2678 2473 1828 1902 1626 M11988 GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MONOVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. 83/117 Gene Ontology BP GO:0030004 2.86077674515167e-07 5.10986341466055e-07 1915 1931.54545454545 1829 2.60070647013974e-08 488 1.97542928208806 -1.76173949974391 -1 13.3002306145846 1915 1667 1829 3288 2562 1644 2464 488 3427 716 1247 1627 M11265 GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. 76/105 Gene Ontology BP GO:1901606 2.16559057281152e-07 4.18632859796095e-07 2110 1762.54545454545 1830 1.96871889634862e-08 202 2.17528176367012 -2.65857676659289 -1 14.8604940855779 2106 202 1558 1699 2365 1830 2801 1119 1720 2105 1883 1628 M12215 GO_MEMBRANE_TUBULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_TUBULATION.html A modification in a plasma membrane resulting in formation of a tubular invagination. 11/14 Gene Ontology BP GO:0097320 1.39628256931644e-07 3.11452674737746e-07 520 1801 1830 1.26934787084987e-08 520 1.27793158359474 -1.32283668206671 -1 8.86071184018914 1830 1034 2799 2753 2030 1640 520 1021 2766 2898 520 1629 M12526 GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_GRANULAR_LAYER_DEVELOPMENT.html The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. 14/23 Gene Ontology BP GO:0021681 1.11556719576445e-07 2.73464517357268e-07 3480 1904.81818181818 1830 1.01415204757472e-08 45 3.68459418408596 3.65110269939831 1 25.9852626777017 3477 912 537 59 1830 3463 4074 2046 45 843 3667 1630 M16771 GO_INTESTINAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_ABSORPTION.html Any process in which nutrients are taken up from the contents of the intestine. 37/58 Gene Ontology BP GO:0050892 3.16805575674164e-08 1.97691467186943e-07 2410 1715.45454545455 1830 2.8800507294204e-09 467 3.55094571067849 -3.93127062292025 -1 25.5786368105869 2407 2331 533 937 467 2947 3008 991 1830 1389 2030 1631 M11103 GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 374/577 Gene Ontology BP GO:0019221 1.94252168260756e-07 3.90265690378799e-07 1070 1967.27272727273 1831 1.76592895829575e-08 712 2.06802193593914 -1.91043782184246 -1 14.1901808795782 1066 2985 1221 3294 2277 1141 1831 1993 3371 712 1749 1632 M14373 GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 195/240 Gene Ontology BP GO:0043242 1.39627959596305e-07 3.11452674737746e-07 1605 1710.81818181818 1831 1.26934516780099e-08 837 1.90706249554861 1.96833891826713 1 13.2785547361299 1605 1485 1982 1831 2029 1624 2040 2557 837 854 1975 1633 M12722 GO_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. 422/660 Gene Ontology BP GO:0050708 2.02856467687697e-08 1.97691467186943e-07 4065 2259.63636363636 1833 1.84414972325623e-09 109 2.26984314852251 2.28090673357046 1 16.3096280546748 4064 1308 234 109 1048 3755 3541 4236 1833 200 4528 1634 M14612 GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis. 81/143 Gene Ontology BP GO:0002688 7.92592482692132e-08 2.34750657031604e-07 2280 1859 1836 7.2053864658801e-09 338 2.74467683869441 2.75444561503469 1 19.5241039610562 2277 1673 388 1836 1486 1834 2587 2850 2564 338 2616 1635 M16559 GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_ALCOHOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it. 42/64 Gene Ontology BP GO:0034308 2.37987283778538e-08 1.97691467186943e-07 1840 1896.54545454545 1836 2.16352078502718e-09 218 2.35290822437735 -2.76815974502915 -1 16.910618902834 1836 1781 1262 2280 218 2240 2641 1526 3504 1685 1889 1636 M10923 GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADENYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity. 33/56 Gene Ontology BP GO:0045762 1.81511068784861e-08 1.97691467186943e-07 1745 1945.09090909091 1838 1.65010063893107e-09 84 2.02648982558892 2.09483293094811 1 14.5489227468534 1741 1838 2089 1969 84 1274 1474 3982 3327 2033 1585 1637 M15714 GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_DISASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. 250/307 Gene Ontology BP GO:0043244 7.14781326684291e-08 2.23814099129341e-07 1840 1801.09090909091 1838 6.49801227188708e-09 943 1.79614749663146 1.95467321820813 1 12.7778723346628 1838 1408 2488 1473 1394 2054 2205 2929 1239 943 1841 1638 M11902 GO_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 100/164 Gene Ontology BP GO:0002028 1.12556617915357e-07 2.74557763766229e-07 3930 1832.81818181818 1839 1.02324203339992e-08 70 2.46632264072133 2.92506826795384 1 17.3515076693155 3927 70 523 141 1839 3374 3045 2556 1094 241 3351 1639 M12651 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that activates or increases the frequency, rate, or extent of leukocyte migration. 92/148 Gene Ontology BP GO:0002687 3.11947381630233e-08 1.97691467186943e-07 1925 1719.45454545455 1839 2.83588532775879e-09 272 2.61260240899493 2.52605287347322 1 18.7895533005834 1922 1644 386 1839 452 1669 2337 2540 3159 272 2694 1640 M16485 GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of insulin receptor signaling. 61/96 Gene Ontology BP GO:0046626 1.05536975920762e-06 1.46981008368545e-06 2270 2076.81818181818 1839 9.59427514075559e-08 1418 2.22336956284967 2.92825933792962 1 13.8827364703449 2268 1723 2284 1788 3303 1714 1461 2419 1839 2628 1418 1641 M13403 GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 29/38 Gene Ontology BP GO:0045662 3.88543113630108e-07 6.49853022185799e-07 2995 1744.09090909091 1840 3.53221074773564e-08 265 2.90606947816546 3.47299046875057 1 19.2919042250426 2994 1840 786 754 2747 2367 2429 2270 265 995 1738 1642 M10317 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. 41/52 Gene Ontology BP GO:0050732 1.92236326827216e-08 1.97691467186943e-07 2700 1594.45454545455 1841 1.74760298642710e-09 106 1.83387454132466 -1.63952005996231 -1 13.155316326019 2890 502 2696 840 106 2221 2698 1841 831 2115 799 1643 M15852 GO_POSITIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AUTOPHAGY.html Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 98/126 Gene Ontology BP GO:0010508 2.11356455496896e-07 4.11998989286576e-07 1055 1819.54545454545 1842 1.92142250729226e-08 102 1.45176063028735 -1.49870663473593 -1 9.89099219333809 1055 102 3530 1650 2344 495 1842 1942 2640 3912 503 1644 M16296 GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway. 22/35 Gene Ontology BP GO:0032925 1.12652290023217e-07 2.74578892340507e-07 685 1642.81818181818 1842 1.02411177992403e-08 118 1.56379761372114 1.76614051236172 1 10.9604612333862 682 3149 3057 2851 1842 729 633 388 2034 2588 118 1645 M14429 GO_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. 132/179 Gene Ontology BP GO:0006006 6.09394018418869e-08 2.10975473787425e-07 1975 1855.45454545455 1843 5.53994577544469e-09 1234 1.75550026637193 -1.64192277471687 -1 12.5347533507065 1972 1598 2826 2524 1234 1355 2024 1320 1843 1775 1939 1646 M14095 GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. 15/21 Gene Ontology BP GO:1900273 8.32836842194693e-07 1.2045973971812e-06 1065 2079.54545454545 1844 7.57124688614007e-08 820 3.62342150863129 3.24215338175053 1 23.0338324808069 1064 3516 1599 2555 3184 1492 820 1844 1700 2693 2408 1647 M11460 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 45/65 Gene Ontology BP GO:0010765 2.23020656627526e-07 4.26516693500977e-07 2900 1819.27272727273 1846 2.02746072032553e-08 206 2.5443371381222 2.96993870593716 1 17.3786440092926 2896 418 1122 206 2390 2747 2525 1846 678 775 4409 1648 M10321 GO_REGULATION_OF_COLLATERAL_SPROUTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COLLATERAL_SPROUTING.html Any process that modulates the frequency, rate or extent of collateral sprouting. 25/35 Gene Ontology BP GO:0048670 4.43320983859088e-07 7.17236626528628e-07 1350 1796.18181818182 1849 4.03019157447745e-08 610 2.74775712642593 2.98413072380667 1 18.1077263291005 1350 2400 1377 833 2840 1849 1260 2656 610 1909 2674 1649 M13565 GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. 30/52 Gene Ontology BP GO:0002726 2.43057651955477e-06 3.05992222551092e-06 140 1950.18181818182 1849 2.20961745898011e-07 138 1.33824625261204 -1.32160316305797 -1 7.8510666445705 138 604 2884 2822 3666 485 1257 1849 4227 2292 1228 1650 M16268 GO_NEGATIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURON_DEATH.html Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. 210/276 Gene Ontology BP GO:1901215 1.13382477747073e-07 2.75780799245756e-07 1850 2099.36363636364 1849 1.03074985082293e-08 297 2.12971128715466 2.42915987663827 1 14.9634475395926 3094 2611 1391 297 1849 2929 2942 1847 1226 1373 3534 1651 M11515 GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_OLIGOMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein oligomerization. 20/25 Gene Ontology BP GO:0032461 4.29677509860689e-08 1.97691467186943e-07 2680 1985.63636363636 1851 3.90615925684212e-09 817 2.66515191343112 -2.41736590188832 -1 19.1697584700417 2678 855 1216 1214 817 2190 3258 3696 2324 1851 1743 1652 M11843 GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). 446/684 Gene Ontology BP GO:0032787 2.15828908561656e-08 1.97691467186943e-07 1855 1839.72727272727 1851 1.96208100617295e-09 160 2.01839918045129 -1.90835783516373 -1 14.4903854658917 1851 1298 985 2689 160 1673 2359 2960 2282 1371 2609 1653 M15541 GO_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_STORAGE.html The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 29/37 Gene Ontology BP GO:0019915 1.46887712472242e-06 1.95743820833371e-06 875 1812.81818181818 1851 1.33534373222783e-07 404 2.00709908117282 -2.23581719188467 -1 12.2518167309718 873 1851 1867 2717 3462 884 1672 1946 3438 827 404 1654 M15424 GO_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 246/358 Gene Ontology BP GO:0009636 4.02449082350615e-08 1.97691467186943e-07 3055 2215.18181818182 1852 3.65862808829702e-09 741 2.0777097090399 2.26181030637349 1 14.9195078679891 3052 1424 1187 1717 741 3164 3313 2823 1852 1708 3386 1655 M14313 GO_ACIDIC_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACIDIC_AMINO_ACID_TRANSPORT.html The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/26 Gene Ontology BP GO:0015800 2.68039415209285e-08 1.97691467186943e-07 2160 1895 1853 2.43672198613611e-09 313 1.98131910623773 2.14174879829033 1 14.2221044221187 2159 920 1853 2075 313 2589 3739 3472 1003 1344 1378 1656 M13218 GO_GALACTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GALACTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. 16/16 Gene Ontology BP GO:0006012 5.00390260864723e-07 7.90063075603515e-07 1855 2196.36363636364 1855 4.54900340616894e-08 1243 1.87456781827969 -1.51465485594365 -1 12.2324976502477 1855 2881 2874 3310 2913 1425 1850 1294 1652 2863 1243 1657 M16109 GO_FEMALE_GENITALIA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEMALE_GENITALIA_DEVELOPMENT.html The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. 20/23 Gene Ontology BP GO:0030540 7.52468333084918e-08 2.28689428729205e-07 3425 2133.63636363636 1855 6.84062144383339e-09 279 2.43581498199826 3.22593306151623 1 17.3441707064622 3422 839 1351 279 1437 3209 3238 3983 1212 1855 2645 1658 M15674 GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune effector process. 410/673 Gene Ontology BP GO:0002697 2.09935997699612e-07 4.10371103569752e-07 1075 1737.36363636364 1856 1.90850925211684e-08 652 2.04136906307647 -1.92288266791638 -1 13.9577748769467 1072 2128 750 2701 2337 1104 2210 1856 3285 652 1016 1659 M16127 GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 20/20 Gene Ontology BP GO:0009226 8.36443758447642e-07 1.20831195531105e-06 780 2207.81818181818 1856 7.60403705877416e-08 777 1.31717672201248 -1.25068331194509 -1 8.29931309531792 777 2814 3248 3627 3187 1003 1293 1558 3144 1856 1779 1660 M11344 GO_THYROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. 9/17 Gene Ontology BP GO:0042403 1.05055138651852e-07 2.64657043934525e-07 4355 2297.45454545455 1859 1.05055143618314e-08 79 3.83412545366559 2.46520536184934 1 27.1032388998639 4353 1093 4294 481 1859 4410 3187 469 79 1819 3228 1661 M14300 GO_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 65/100 Gene Ontology BP GO:0046631 4.98934191094447e-07 7.89102920177587e-07 930 2070.81818181818 1859 4.53576640224458e-08 927 1.80339800586902 -1.69185820020602 -1 11.7648128321705 927 1702 2228 2390 2908 1314 2266 1807 3760 1618 1859 1662 M13253 GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ORGAN_DEVELOPMENT.html The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. 128/205 Gene Ontology BP GO:0060538 8.45058814588448e-08 2.41675394239708e-07 2590 1751.18181818182 1861 7.68235315498772e-09 759 2.45173193877228 3.12933905576279 1 17.3947785709032 2587 1599 759 2072 1553 2049 2427 2379 825 1152 1861 1663 M16418 GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 30/30 Gene Ontology BP GO:0051984 4.31898631297642e-07 7.01684473263941e-07 500 1906.45454545455 1862 3.92635196442682e-08 213 1.70436597307328 1.94152514647957 1 11.2063422716325 497 1862 3157 3431 2826 1013 213 1659 2020 2975 1318 1664 M16846 GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION_INVOLVED_IN_PHOSPHOLIPASE_C_ACTIVATING_G_PROTEIN_COUPLED_SIGNALING_PATHWAY.html Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. 9/22 Gene Ontology BP GO:0051482 6.05900525053962e-08 2.10549301200604e-07 4360 2708.18181818182 1862 6.05900541574157e-09 1090 3.87095531780259 -4.28597059181689 -1 27.7796389449203 4360 1090 4648 1862 1321 4485 3934 1368 1780 1268 3674 1665 M10211 GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE.html The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. 12/14 Gene Ontology BP GO:0008608 1.6482749902538e-06 2.16222822939129e-06 755 2017.45454545455 1863 1.49843293197175e-07 751 1.90954115601747 2.18572565151558 1 11.5617464400823 751 3233 2517 3078 3516 1215 878 1863 1371 2013 1757 1666 M15393 GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_GLUTAMATE_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-glutamate across a membrane. 9/13 Gene Ontology BP GO:0089711 1.52716491597698e-07 3.30199737641305e-07 1865 2100.90909090909 1863 1.52716502092745e-08 787 2.59973241995998 2.58916511800302 1 18.0713551566709 1863 2074 4550 2085 2174 1735 787 3400 1317 1822 1303 1667 M16920 GO_GOLGI_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. 119/127 Gene Ontology BP GO:0007030 3.41835141471206e-08 1.97691467186943e-07 1865 2470.54545454545 1863 3.10759224347842e-09 556 1.26460340981663 -1.25161170835747 -1 9.03653672295909 1801 3342 4034 4205 556 1021 1863 1862 2593 4264 1635 1668 M16042 GO_MULTICELLULAR_ORGANISM_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_REPRODUCTION.html The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. 683/1283 Gene Ontology BP GO:0032504 4.74338857646024e-08 1.98252330758246e-07 1575 2324.45454545455 1864 4.74338867770905e-09 1056 2.0228593630777 2.02104938261636 1 14.519969616169 1574 3298 4588 3281 1056 1570 1820 1405 2328 1864 2785 1669 M12748 GO_REGULATION_OF_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDE_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 304/457 Gene Ontology BP GO:0090087 6.82858605003499e-08 2.20495564821741e-07 3010 1980.81818181818 1869 6.20780569271605e-09 237 2.22953037276687 2.36549331086751 1 15.9038762141645 3010 1374 744 237 1348 2521 2533 3996 1869 702 3455 1670 M12206 GO_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_FORMATION.html The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. 32/47 Gene Ontology BP GO:0048645 2.99235364609589e-07 5.29206442998258e-07 1610 1775.27272727273 1870 2.72032186645833e-08 313 2.93734522830604 3.49757179807249 1 19.7834841567928 1607 1841 1266 313 2590 1870 2305 2215 875 2545 2101 1671 M13291 GO_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. 34/76 Gene Ontology BP GO:0042446 2.41301368034261e-08 1.97691467186943e-07 2525 1880.63636363636 1870 2.19364882437194e-09 237 2.1801330220481 -2.07320615311381 -1 15.6605590633633 2523 1827 1494 2256 237 2044 1833 1684 2869 1870 2050 1672 M13316 GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 18/43 Gene Ontology BP GO:2000516 3.20617424344215e-08 1.97691467186943e-07 1870 1862.90909090909 1870 2.91470390015217e-09 480 2.37353794091697 -2.62377645413859 -1 17.0598786333866 1870 1965 1569 1406 480 2798 3869 1652 1878 1890 1115 1673 M11324 GO_PITUITARY_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PITUITARY_GLAND_DEVELOPMENT.html The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. 29/63 Gene Ontology BP GO:0021983 1.86203117539225e-07 3.79398041343867e-07 3200 1928.81818181818 1871 1.69275575726405e-08 664 2.67079138886387 2.88401486660552 1 18.3945324102478 3198 664 1025 1231 2241 3010 1719 2564 1871 826 2868 1674 M13488 GO_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BROWN_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 34/40 Gene Ontology BP GO:0050873 2.28714670592404e-07 4.34371168272023e-07 1200 2097.09090909091 1871 2.07922449427148e-08 789 2.22696021219195 2.12588024225395 1 15.1777026235019 1199 3416 1610 3607 2404 955 789 2312 3751 1871 1154 1675 M13847 GO_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). 193/553 Gene Ontology BP GO:0002250 1.48724411874162e-07 3.25194872392141e-07 1140 1835.90909090909 1871 1.35204019934756e-08 732 2.15096481233737 -2.21254587743563 -1 14.9477401896755 1138 2167 828 1871 2076 2177 3191 1699 2626 732 1690 1676 M16437 GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor. 10/15 Gene Ontology BP GO:1900121 1.9807273511172e-08 1.97691467186943e-07 4650 2570.45454545455 1872 1.80066124450027e-09 119 2.07190459918463 -1.15371137027646 -1 14.8775068481902 4646 1027 1584 1504 119 4224 4138 3184 1872 1573 4404 1677 M15489 GO_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 60/79 Gene Ontology BP GO:0046677 2.83399420987415e-06 3.50944145540613e-06 1720 2163.63636363636 1875 2.57636169143008e-07 990 2.28642496478758 2.68240980154873 1 13.3469737416753 1719 2684 1875 1645 3730 1948 2363 990 1792 3395 1659 1678 M12325 GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. 14/31 Gene Ontology BP GO:0021895 3.46135798690206e-08 1.97691467186943e-07 4520 2172 1876 3.14668912851012e-09 52 2.67577985551095 -1.28880370744467 -1 19.2466535533123 4518 2892 1876 654 571 4161 3031 719 52 1529 3889 1679 M13375 GO_REGULATION_OF_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_EXTRAVASATION.html Any process that modulates the frequency, rate, or extent of cellular extravasation. 21/37 Gene Ontology BP GO:0002691 5.849125656051e-08 2.0762333639785e-07 3070 2232 1876 5.31738710141938e-09 610 2.60581711798016 2.61781409615598 1 18.6805920010966 3068 801 1374 1876 1195 3884 4519 610 3193 1285 2747 1680 M15144 GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 149/237 Gene Ontology BP GO:0070374 1.17560363270663e-07 2.82410554926575e-07 2045 2071.27272727273 1876 1.0687306322971e-08 478 2.46728515687037 2.29387355526485 1 17.3257119841424 2045 3009 478 1235 1876 1102 1795 4186 3128 633 3297 1681 M13549 GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. 37/70 Gene Ontology BP GO:0071622 4.97755154379521e-07 7.87505859683071e-07 2030 1829 1877 4.52504788179842e-08 545 2.56617572761722 2.51898313547575 1 16.7912129615991 2028 2329 858 1877 2907 1581 1599 2245 3251 545 899 1682 M12052 GO_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. 78/117 Gene Ontology BP GO:0030183 8.15069113553797e-08 2.37217088783313e-07 4415 2508.09090909091 1878 7.40971948864511e-09 210 2.44330695127113 -2.11331539413088 -1 17.3559386806557 4412 210 1257 1002 1516 4527 4183 3679 720 1878 4205 1683 M14047 GO_ACTIVATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_IMMUNE_RESPONSE.html Any process that initiates an immune response. 389/757 Gene Ontology BP GO:0002253 1.02449137770668e-07 2.61489763053712e-07 1450 2343.36363636364 1878 9.31355841286341e-09 1446 2.01793958458681 -2.03973441135839 -1 14.2225269755762 1446 3305 1878 3170 1757 1751 2502 1736 3104 3457 1671 1684 M14089 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell. 27/43 Gene Ontology BP GO:0051024 1.6950122134399e-06 2.21604153670578e-06 170 1941.27272727273 1878 1.54092138125508e-07 169 1.48344950094253 -1.48521441978163 -1 8.93954955454843 169 1878 2797 2391 3529 649 1117 922 4068 2574 1260 1685 M10138 GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCERALDEHYDE_3_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. 27/30 Gene Ontology BP GO:0019682 3.35460002019742e-07 5.77254212055421e-07 540 1873.90909090909 1880 3.04963684701185e-08 503 1.76854664853436 -1.63693241458214 -1 11.7944013483228 540 1880 2573 2786 2661 1087 1118 503 3274 2568 1623 1686 M15313 GO_SCHWANN_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCHWANN_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. 40/42 Gene Ontology BP GO:0014037 7.38523671163078e-08 2.26672205931517e-07 1880 1964.72727272727 1880 6.713851781407e-09 892 1.88150427717518 1.98567133491439 1 13.3792886988868 1880 1780 2068 1572 1421 1503 892 2606 2731 2611 2548 1687 M15794 GO_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. 51/61 Gene Ontology BP GO:0030850 5.96965195563006e-07 9.11312025903761e-07 3125 1797.45454545455 1881 5.42695779589336e-08 278 2.75215461139318 2.95064667228907 1 17.827970941271 3123 1751 1010 278 3005 2170 2283 2201 642 1881 1428 1688 M11003 GO_POLYOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 87/118 Gene Ontology BP GO:0019751 9.0064871761744e-08 2.47798486982639e-07 2080 1809.36363636364 1882 8.18771594989745e-09 162 1.76145359629887 -1.9539382296781 -1 12.4448276134118 2079 162 2438 2718 1622 1882 2601 413 1004 3634 1350 1689 M12134 GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 14/26 Gene Ontology BP GO:0071257 3.62090115462078e-06 4.39667355752884e-06 1645 2035.81818181818 1882 3.29173374013269e-07 498 3.04215222617652 -2.91725901548522 -1 17.4745242866909 1642 3535 1882 1757 3805 2125 734 2773 498 1954 1689 1690 M11161 GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTION_POTENTIAL.html Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 13/21 Gene Ontology BP GO:0045760 1.18468116007426e-07 2.83555629517774e-07 3495 2074.18181818182 1883 1.07698293078939e-08 77 3.16115659124719 -2.21982375270979 -1 22.2240106098542 3492 2528 1530 1219 1883 3063 2945 77 341 1328 4410 1691 M12500 GO_LYMPHOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. 339/544 Gene Ontology BP GO:0046649 6.96404582319045e-08 2.21185701128363e-07 4455 2470.09090909091 1883 6.33095094875965e-09 128 2.19936344458343 -1.99260741255033 -1 15.6839351716239 4452 1340 532 128 1371 4643 4279 4595 1883 456 3492 1692 M10807 GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 20/27 Gene Ontology BP GO:0009065 1.73170814266263e-06 2.25767385480785e-06 2205 1969 1885 1.57428136887363e-07 836 2.59424476497248 -3.46901733827141 -1 15.6954687027924 2202 836 1681 1885 3539 1676 1756 1976 2817 2245 1046 1693 M13996 GO_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 27/41 Gene Ontology BP GO:0071887 9.15446951324715e-08 2.49206886189644e-07 3550 2354.63636363636 1885 8.32224535834172e-09 663 1.96077141323156 -2.60427410363599 -1 13.8606148574071 3549 1885 2348 1431 1641 3276 3825 3891 663 1874 1518 1694 M14486 GO_RESPONSE_TO_MUSCLE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_ACTIVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. 36/61 Gene Ontology BP GO:0014850 4.28487923439779e-08 1.97691467186943e-07 1290 1865.63636363636 1885 3.895344834412e-09 663 2.55310053563167 2.90778942965735 1 18.359046484432 1290 3093 1885 2583 812 1475 663 2840 2010 2101 1770 1695 M16521 GO_MONOAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOAMINE_TRANSPORT.html The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/24 Gene Ontology BP GO:0015844 3.43371028757018e-06 4.18466578524464e-06 3175 1893.90909090909 1885 3.12155967894483e-07 249 2.23716168564071 -1.65216416785153 -1 12.8724469164242 3173 1010 1576 1201 3791 2892 2433 249 1885 2028 595 1696 M16505 GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 33/41 Gene Ontology BP GO:0043536 7.52166712745673e-08 2.28689428729205e-07 2225 2099.27272727273 1887 6.83787944056182e-09 607 1.70833474052129 1.71203400082504 1 12.1303848006104 2224 607 2490 1237 1436 1887 1298 4458 1816 2039 3600 1697 M13368 GO_GRANULOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_MIGRATION.html The movement of a granulocyte within or between different tissues and organs of the body. 61/100 Gene Ontology BP GO:0097530 1.49559512081212e-07 3.25796071963426e-07 1680 1865.72727272727 1888 1.35963202044097e-08 679 2.7130288105152 -2.99256444311808 -1 18.8809067086082 1679 2274 679 2478 2083 1858 2370 913 3466 835 1888 1698 M12864 GO_BONE_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_MINERALIZATION.html The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. 41/53 Gene Ontology BP GO:0030282 9.84441918263598e-08 2.57032100060153e-07 3715 2039.63636363636 1889 8.94947238467982e-09 571 3.13108427357021 -2.54062975207912 -1 22.1556404856624 3715 2312 571 1889 1715 3650 3449 601 2253 1120 1161 1699 M13943 GO_LIPID_PARTICLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PARTICLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. 14/19 Gene Ontology BP GO:0034389 3.22682743072975e-07 5.60448974810956e-07 1890 2122.90909090909 1889 2.93347991274677e-08 157 1.27013783757458 -1.43642470129749 -1 8.4562386358653 1889 3216 3370 2146 2637 1408 1652 1489 1400 3988 157 1700 M13456 GO_DNA_REPLICATION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INITIATION.html The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. 29/31 Gene Ontology BP GO:0006270 0.000103397669027581 0.000109194133904979 15 2078.81818181818 1890 9.40022990256816e-06 15 1.3865437743764 1.3865437743764 1 5.81534756863554 15 2773 3190 2872 4455 516 112 1297 3917 1830 1890 1701 M14552 GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_VESICLE_MEDIATED_TRANSPORT_GOLGI_TO_ER.html The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. 86/91 Gene Ontology BP GO:0006890 3.19908031761343e-08 1.97691467186943e-07 1895 2170.45454545455 1891 2.90825487648375e-09 150 1.23614035908414 -0.86537361065443 -1 8.83060140267104 1891 150 3913 2878 476 848 636 4138 1383 4199 3363 1702 M10757 GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of an adaptive immune response. 115/220 Gene Ontology BP GO:0002819 2.33894496597428e-07 4.40968838196042e-07 1335 2167.54545454545 1892 2.12631383149167e-08 1265 1.70840545762534 -1.77754120929627 -1 11.605120271808 1333 1613 2432 2416 2423 1892 3264 1265 3927 1836 1442 1703 M13734 GO_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_BURST.html A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 18/26 Gene Ontology BP GO:0045730 2.83440382321432e-06 3.50944145540613e-06 2410 1860.27272727273 1892 2.57673406815331e-07 373 2.48592734793208 -2.73429990555464 -1 14.521434468607 2406 1957 1338 1178 3731 2612 2828 528 373 1892 1620 1704 M10160 GO_CERAMIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid. 11/13 Gene Ontology BP GO:0046514 6.24956551357139e-07 9.45588698666089e-07 1895 2203.18181818182 1893 5.68142480808493e-08 1075 1.36192282788866 -1.63805644442787 -1 8.74159578181448 1893 1075 3138 3869 3035 1478 1552 1818 2351 2894 1132 1705 M10893 GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOGENOUS_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. 6/48 Gene Ontology BP GO:0042738 2.09773929977373e-05 2.33009810500052e-05 1965 2187 1893 2.09775910233259e-06 996 5.19959255577783 -5.99140731110386 -1 25.8831783051508 1963 2964 4269 1544 4188 1761 996 1249 1066 2164 1893 1706 M13791 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. 42/66 Gene Ontology BP GO:0002639 6.63209359074565e-07 9.95777072531123e-07 550 2037.63636363636 1893 6.02917780913588e-08 500 1.48351262163821 -1.45143510329607 -1 9.49616599261839 547 500 2999 2372 3063 1384 1893 1433 3809 2837 1577 1707 M15436 GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. 18/22 Gene Ontology BP GO:0044320 1.00549977024585e-06 1.41091388146983e-06 3710 2241.27272727273 1894 9.14091118004674e-08 293 2.85251852258184 -2.41722988727917 -1 17.8978275775384 3706 1950 1296 1001 3278 3569 4545 1724 293 1894 1398 1708 M10614 GO_RESPONSE_TO_ACID_CHEMICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACID_CHEMICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. 387/549 Gene Ontology BP GO:0001101 6.06706987323367e-12 1.69042371976984e-10 2120 1556.72727272727 1896 5.51551806659128e-13 119 2.5092835923006 2.79085579771404 1 26.3504464367902 2117 1321 119 149 491 1896 2890 3378 2141 278 2344 1709 M10874 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. 56/130 Gene Ontology BP GO:0002704 7.0314242115194e-07 1.04628131935401e-06 850 2131.27272727273 1898 6.3922058716684e-08 846 1.58820125981885 -1.55276938452643 -1 10.1374448931393 846 1725 2538 3399 3092 978 1955 1564 4409 1898 1040 1710 M12290 GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_LIPASE_ACTIVITY.html Any process that modulates the activity of the enzyme lipoprotein lipase. 7/17 Gene Ontology BP GO:0051004 1.32532421056934e-07 3.01846967781652e-07 2580 1901.72727272727 1899 1.32532428961114e-08 197 2.36167569004936 -2.77382954041577 -1 16.5055874494231 2421 2580 4361 1849 2060 2579 1899 765 197 1839 369 1711 M11558 GO_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SENESCENCE.html A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. 47/66 Gene Ontology BP GO:0090398 1.46428288242368e-06 1.95329116979013e-06 2125 1991.81818181818 1900 1.33116714275143e-07 321 2.51415780264263 2.79084341922495 1 15.3780967957618 2122 3386 1900 1264 3458 2209 1309 321 1159 3267 1515 1712 M15824 GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. 27/35 Gene Ontology BP GO:2000352 4.77099573047476e-07 7.61297775510941e-07 1900 2028.81818181818 1900 4.33726978648148e-08 723 2.60142396301094 2.35823116860059 1 17.0646742681201 1900 723 1181 1367 2883 2107 2053 3154 1870 1876 3203 1713 M10228 GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELINATION_IN_PERIPHERAL_NERVOUS_SYSTEM.html The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. 26/28 Gene Ontology BP GO:0022011 1.49298928100652e-07 3.25796071963426e-07 1090 1992.63636363636 1901 1.35726307484135e-08 850 1.73062992218169 1.85714604252233 1 12.0030996151025 1087 1901 2803 3090 2078 850 855 1122 3985 3130 1018 1714 M14489 GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 61/109 Gene Ontology BP GO:0010830 7.04467742960824e-08 2.22531460149132e-07 1875 1901.36363636364 1901 6.404252413807e-09 1064 2.0956961314116 -2.1219619123039 -1 14.9333814872603 1874 1716 1928 1945 1378 2178 2394 1854 2683 1901 1064 1715 M15167 GO_EMBRYONIC_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_EYE_MORPHOGENESIS.html The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. 39/53 Gene Ontology BP GO:0048048 1.38386007064801e-07 3.10507150322305e-07 2635 1910.90909090909 1901 1.25805468881509e-08 1060 2.78430645378515 3.44677651790767 1 19.4426490774481 2633 1789 1060 1901 2016 2106 1941 3254 1375 1370 1575 1716 M15962 GO_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLATHRIN_MEDIATED_ENDOCYTOSIS.html An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. 42/51 Gene Ontology BP GO:0072583 5.28140820943278e-08 2.04581932255101e-07 3250 1937.27272727273 1901 4.80128030565491e-09 121 1.62879492644107 -1.13239606224095 -1 11.645372598727 3248 446 2749 640 1073 1901 1706 2458 121 3083 3885 1717 M14616 GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_AXON_ENSHEATHMENT.html The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. 26/28 Gene Ontology BP GO:0032292 1.49298928100652e-07 3.25796071963426e-07 1090 2001.09090909091 1902 1.35726307484135e-08 851 1.73062992218169 1.85714604252233 1 12.0030996151025 1088 1902 2804 3091 2079 851 856 1201 3986 3135 1019 1718 M16823 GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_LOCALIZATION.html A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. 27/30 Gene Ontology BP GO:0034629 9.07021980984886e-08 2.48403371249127e-07 1905 1916.54545454545 1903 8.24565471254399e-09 712 1.97788285553246 1.96241791848495 1 13.9855558320844 1903 712 2512 2131 1631 1968 1338 3759 2721 1545 862 1719 M14522 GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 38/45 Gene Ontology BP GO:1902042 4.45164568244847e-08 1.97691467186943e-07 3125 1955.63636363636 1904 4.04695070229674e-09 516 2.01931525563407 -1.81575445901024 -1 14.4970134355336 3124 516 1643 1904 868 2843 3507 2659 1057 1245 2146 1720 M16223 GO_ADAPTATION_OF_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTATION_OF_SIGNALING_PATHWAY.html The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. 18/26 Gene Ontology BP GO:0023058 3.04517420844144e-07 5.36305662069569e-07 3320 2117.27272727273 1905 2.76834057267766e-08 891 1.73621792085508 1.91768146959061 1 11.6366104841734 1404 891 2173 3316 2603 1009 1634 3141 3318 1896 1905 1721 M12588 GO_REGULATION_OF_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESODERM_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of mesoderm development. 16/28 Gene Ontology BP GO:2000380 1.80425738143466e-07 3.71141007772568e-07 1620 1732 1906 1.64023411764081e-08 950 2.56388044017979 3.22327028248957 1 17.6801197736914 1618 950 1673 1268 2218 1998 1120 1923 1906 2397 1981 1722 M12721 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. 28/58 Gene Ontology BP GO:0002686 5.31814850214345e-08 2.04903449305918e-07 4125 2532.27272727273 1906 4.83468057336473e-09 1025 2.67280000787172 -2.5610632706096 -1 19.1802060299722 4121 1866 1194 3273 1082 4596 4225 1906 1025 1109 3458 1723 M14107 GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. 23/45 Gene Ontology BP GO:0050996 4.15777483528042e-07 6.82858990575346e-07 3540 2368.63636363636 1906 3.7797960191432e-08 647 2.40039683096423 -2.12479404124057 -1 15.8595846154834 3537 1906 1779 1512 2795 4165 4456 2614 647 1271 1373 1724 M13794 GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells. 23/51 Gene Ontology BP GO:0045589 1.13595647212055e-06 1.56842892129879e-06 310 2181.27272727273 1907 1.0326882351501e-07 306 1.21651147110087 -1.16753022960406 -1 7.50766187370871 306 1907 3109 3401 3336 577 936 1413 4417 3101 1491 1725 M14628 GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that modulates the frequency, rate or extent of lamellipodium organization. 68/81 Gene Ontology BP GO:1902743 4.32266526018029e-08 1.97691467186943e-07 3865 2098.18181818182 1907 3.92969576828552e-09 253 2.05021161852952 2.53198122204493 1 14.7205542094447 3863 253 1907 848 825 3767 4167 2832 625 2310 1683 1726 M12514 GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_OTHER_ORGANISM.html Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. 408/924 Gene Ontology BP GO:0098542 3.21497858704515e-07 5.5922599497275e-07 1105 1981.18181818182 1908 2.92270823351582e-08 469 2.2495959272566 -2.1475488933269 -1 15.0667269699266 1102 3304 469 2702 2634 1690 2114 1406 3416 1048 1908 1727 M14516 GO_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPOLYMERIZATION.html The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. 35/40 Gene Ontology BP GO:0051261 8.37201918926249e-08 2.40389942771476e-07 1760 1889.45454545455 1908 7.61092682532422e-09 759 1.92860412928631 1.66572775155503 1 13.6639312470105 1756 1813 2022 759 1544 1721 1928 2469 1908 2625 2239 1728 M12280 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development. 10/15 Gene Ontology BP GO:1901722 1.35124520231931e-06 1.81853887353196e-06 1910 2005.27272727273 1909 1.22840548387093e-07 260 2.29809025626139 3.265982729397 1 14.1237738858546 1909 3265 2602 2410 3425 1538 260 338 1688 3974 649 1729 M13385 GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of activation. 272/554 Gene Ontology BP GO:0050867 5.96280211897081e-08 2.09276523367486e-07 2065 2087 1910 5.42072934598592e-09 614 2.00619972402861 -1.81485244313931 -1 14.3485703342062 2063 2144 1128 1910 1212 1779 3222 3477 3507 614 1901 1730 M13512 GO_POSITIVE_REGULATION_OF_AXON_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_AXON_EXTENSION.html Any process that activates or increases the frequency, rate or extent of axon extension. 49/54 Gene Ontology BP GO:0045773 2.61107649456394e-07 4.74954610211338e-07 1390 2200.36363636364 1910 2.37370618587307e-08 1387 2.40699044609466 2.61599842009867 1 16.3130622635837 1387 3916 1837 2139 2517 1709 1910 2218 1900 3211 1460 1731 M16250 GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOCYTE_CHEMOTAXIS.html Any process that increases the frequency, rate, or extent of monocyte chemotaxis. 14/23 Gene Ontology BP GO:0090026 4.33408106471474e-07 7.02909696553422e-07 2130 1659.09090909091 1910 3.94007447140446e-08 178 3.14056097310439 3.01493730083151 1 20.7421734559067 2129 973 959 188 2830 2626 2997 1910 178 1966 1494 1732 M12222 GO_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JAK_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway. 108/201 Gene Ontology BP GO:0046425 5.66387846056023e-08 2.06206675362389e-07 4440 2471.27272727273 1911 5.14898055125114e-09 83 2.39850368381571 2.76030945736689 1 17.1931017053043 4439 83 851 814 1156 4271 4603 3973 1911 1106 3977 1733 M12009 GO_DECIDUALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DECIDUALIZATION.html The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. 20/25 Gene Ontology BP GO:0046697 2.36366970982958e-08 1.97691467186943e-07 1240 1673.45454545455 1912 2.14879066838612e-09 210 2.32730952701943 -2.82989521676248 -1 16.7254076972993 1239 2838 1976 2776 210 1912 1818 229 2176 2248 986 1734 M14805 GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of DNA biosynthetic process. 108/119 Gene Ontology BP GO:2000278 1.94515453959122e-07 3.90403703253565e-07 815 2191.72727272727 1912 1.7683224650675e-08 398 1.88806996154058 2.1429412780175 1 12.9452471350903 814 3887 3191 3557 2279 802 398 1912 1636 4193 1440 1735 M15845 GO_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STAT_CASCADE.html Any process that modulates the frequency, rate or extent of STAT cascade. 108/201 Gene Ontology BP GO:1904892 5.66387846056023e-08 2.06206675362389e-07 4440 2473.81818181818 1912 5.14898055125114e-09 84 2.39850368381571 2.76030945736689 1 17.1931017053043 4440 84 852 815 1157 4272 4604 3991 1912 1107 3978 1736 M13781 GO_CELLULAR_RESPONSE_TO_CHOLESTEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CHOLESTEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. 25/28 Gene Ontology BP GO:0071397 9.11388853145399e-08 2.48910368082321e-07 2105 2197.81818181818 1913 8.28535355364811e-09 785 2.65793368379969 2.89617138892583 1 18.830522754656 2102 1896 1436 1607 1636 2687 2100 4400 3614 1913 785 1737 M14656 GO_ENDOCYTIC_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCYTIC_RECYCLING.html The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport. 29/29 Gene Ontology BP GO:0032456 2.05967692366096e-07 4.05572438670946e-07 1530 2078.72727272727 1913 1.87243374226491e-08 669 1.43376151116327 -1.45723211598604 -1 9.77752511124086 1526 669 3108 2510 2322 1677 1913 3115 1561 2851 1614 1738 M14155 GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule. 83/102 Gene Ontology BP GO:0035305 1.03333185540828e-07 2.62737329137416e-07 1915 2116.63636363636 1914 9.39392639948627e-09 1187 1.95757432381305 -1.85585540974512 -1 13.7893196337078 1914 3032 2827 2284 1764 1411 1596 1643 2211 3414 1187 1739 M11196 GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm. 45/50 Gene Ontology BP GO:0046825 1.22314930106573e-07 2.88167782170068e-07 460 1876 1915 1.11195397188184e-08 205 1.6901560461427 1.87961496235493 1 11.8169643469373 457 3677 3210 2996 1915 471 205 951 2613 3872 269 1740 M10132 GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_SPINDLE_ORIENTATION.html Any process that set the alignment of spindle relative to other cellular structures. 28/33 Gene Ontology BP GO:0051294 4.26746375835712e-08 1.97691467186943e-07 1460 1959.36363636364 1917 3.87951258285046e-09 588 1.74532285433343 2.08429908816452 1 12.5146288539003 1458 2377 2722 3341 807 1717 1917 588 2547 2720 1359 1741 M10865 GO_BETA_AMYLOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_AMYLOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). 16/25 Gene Ontology BP GO:0050435 3.07677806943022e-07 5.4031661702426e-07 1005 1639.36363636364 1917 2.79707136338967e-08 426 1.57447433998408 -1.38266844680242 -1 10.5365258741162 1003 1993 2679 1917 2610 920 475 522 2629 2859 426 1742 M15808 GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. 17/49 Gene Ontology BP GO:0045721 4.57974490775968e-07 7.37865410519591e-07 1920 1714 1917 4.16340532829679e-08 65 2.41458525975653 3.04392472999102 1 15.8663187273564 1917 2857 2006 2104 3195 1950 529 65 1897 1705 629 1743 M16799 GO_RESPONSE_TO_LEPTIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEPTIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. 23/27 Gene Ontology BP GO:0044321 2.74776634868922e-06 3.41398045939945e-06 2665 2009.45454545455 1917 2.49797252783032e-07 324 2.75747150188483 -2.36171708329419 -1 16.1556444275802 2663 1917 1493 1382 3715 2628 3899 738 324 2368 977 1744 M14330 GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of T cell mediated immunity. 53/118 Gene Ontology BP GO:0002709 7.03054230764027e-07 1.04628131935401e-06 625 1939.72727272727 1918 6.39140414035675e-08 338 1.44725022239291 -1.46467623782375 -1 9.22772101454266 622 338 2822 1986 3091 803 1918 2310 4395 1846 1206 1745 M16118 GO_IMMUNOLOGICAL_SYNAPSE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOLOGICAL_SYNAPSE_FORMATION.html The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. 23/51 Gene Ontology BP GO:0001771 4.61776680815459e-08 1.97760774550163e-07 4215 2442.09090909091 1918 4.19796991370983e-09 275 2.6240132799967 3.05569644420647 1 18.8716819139761 4211 1918 1323 275 928 3993 3797 3939 398 1616 4465 1746 M12966 GO_PHOTORECEPTOR_CELL_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTORECEPTOR_CELL_MAINTENANCE.html Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. 37/52 Gene Ontology BP GO:0045494 6.66328849956854e-08 2.18361447198576e-07 1590 2049.27272727273 1919 6.0575351830764e-09 841 2.07116642922931 2.17899196197481 1 14.7756292122035 1589 1804 2036 2080 1320 1822 2457 3123 3551 1919 841 1747 M14562 GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 23/34 Gene Ontology BP GO:0045663 3.06645081123533e-08 1.97691467186943e-07 4390 2205.45454545455 1919 2.78768259452436e-09 390 2.1404286888311 -1.49907917991373 -1 15.373291031039 4389 767 1919 1550 432 3611 4643 390 870 1939 3750 1748 M10811 GO_THYMIC_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYMIC_T_CELL_SELECTION.html The process of T cell selection that occurs in the thymus. 16/27 Gene Ontology BP GO:0045061 4.66599087040659e-07 7.49166750056816e-07 965 1809.63636363636 1922 4.24181078183563e-08 526 1.9583671627534 1.76985990265858 1 12.833173570355 963 2493 2024 3113 2862 996 780 526 2946 1922 1281 1749 M13323 GO_HEART_VALVE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_VALVE_FORMATION.html The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. 21/24 Gene Ontology BP GO:0003188 2.24351481968598e-06 2.84909237336213e-06 2015 1813.81818181818 1922 2.03956100689053e-07 757 2.86936863633668 3.52408604077997 1 17.0590844746649 2014 1930 1157 757 3633 1813 1589 2274 1922 1994 869 1750 M14747 GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of protein depolymerization. 23/30 Gene Ontology BP GO:1901881 2.32786209144279e-08 1.97691467186943e-07 1750 2054.90909090909 1923 2.11623828734031e-09 198 2.05102517778222 1.87996257073287 1 14.7264404577901 1746 1923 2246 2094 198 1484 2228 4633 1554 3103 1395 1751 M16772 GO_MALE_SEX_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DIFFERENTIATION.html The establishment of the sex of a male organism by physical differentiation. 163/273 Gene Ontology BP GO:0046661 3.45527327917856e-08 1.97691467186943e-07 1925 2057.36363636364 1923 3.14115757586031e-09 566 2.18654638142912 2.16357986462517 1 15.7069608784977 1923 3327 1401 2102 566 1851 1060 4173 2228 1663 2337 1752 M13670 GO_PIGMENT_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. 24/29 Gene Ontology BP GO:0048753 9.00170973899028e-07 1.28956143520695e-06 835 2295.63636363636 1925 8.18337583837234e-08 308 0.946470802523999 -1.02797926301414 -1 5.90285658583367 834 1925 3795 4388 3216 501 308 1190 4364 3520 1211 1753 M11295 GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 22/29 Gene Ontology BP GO:0010832 9.64741671992126e-07 1.36483520820291e-06 1295 1894.81818181818 1926 8.77038268227166e-08 275 2.39781331605046 -2.63520396621753 -1 15.0641160084086 1291 1926 1947 1598 3253 2034 1837 275 2773 2977 932 1754 M12567 GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. 20/24 Gene Ontology BP GO:2000269 3.80855493787312e-07 6.39523858748597e-07 1610 1865.72727272727 1927 3.4623232701778e-08 752 2.022253460767 2.0609523536248 1 13.4054935702817 1608 1946 2140 2175 2737 1298 752 1591 948 3401 1927 1755 M11061 GO_DRUG_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease. 10/54 Gene Ontology BP GO:0042737 6.01333911646749e-07 9.16477789352219e-07 1250 1930.27272727273 1929 5.46667341828702e-08 410 4.31068038981668 -4.5584357398195 -1 27.976451304069 1246 2949 1254 1946 3011 1441 410 2010 3475 1562 1929 1756 M10108 GO_MULTICELLULAR_ORGANISM_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_AGING.html An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). 30/39 Gene Ontology BP GO:0010259 7.13934412853482e-08 2.23814099129341e-07 1920 1924.45454545455 1931 6.49031305474339e-09 934 2.69794826168064 2.66551789438711 1 19.2501061821648 1916 1864 1620 2788 1390 2013 1980 2667 934 1931 2066 1757 M14536 GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/28 Gene Ontology BP GO:0010829 7.55012782736341e-07 1.10702955970865e-06 2600 2297.90909090909 1931 6.86375492588647e-08 1262 2.08509933398102 -1.54092150434647 -1 13.2893596592532 2598 1909 1931 1262 3139 3945 3667 1325 1860 2112 1529 1758 M15758 GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_PROTEIN_KINASE_ACTIVITY.html Any process that initiates the activity of an inactive protein kinase. 312/415 Gene Ontology BP GO:0032147 4.56412563782018e-08 1.97760774550163e-07 3770 2239.45454545455 1932 4.14920521137059e-09 243 2.1785724056382 2.23934329835928 1 15.6489098011291 3768 1362 632 243 917 3205 3168 4468 1932 766 4173 1759 M11577 GO_VENTRICULAR_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. 40/67 Gene Ontology BP GO:0021591 2.16339519182197e-07 4.18556250625681e-07 1705 2239.45454545455 1933 1.96672309505632e-08 631 2.2217601287606 2.53418871643439 1 15.1806193435434 1702 3395 2332 3626 2363 1933 1498 631 1834 3603 1717 1760 M11191 GO_POSITIVE_REGULATION_OF_HEART_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_GROWTH.html Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. 35/45 Gene Ontology BP GO:0060421 2.27484068471198e-07 4.33472126096221e-07 2910 1873.90909090909 1934 2.06803719994068e-08 230 3.03936820545487 3.0123247813312 1 20.7588267596936 2907 525 663 241 2399 2212 1934 4570 230 1413 3519 1761 M11467 GO_REGULATION_OF_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXIT_FROM_MITOSIS.html Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. 23/27 Gene Ontology BP GO:0007096 5.83548741090667e-08 2.0762333639785e-07 2830 2118.27272727273 1934 5.30498869608422e-09 467 1.50756982137122 1.41767799431602 1 10.7598063309109 2829 797 2960 1635 1190 2636 1919 3526 467 3408 1934 1762 M16324 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_ENDOGENOUS_ANTIGEN.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. 31/51 Gene Ontology BP GO:0019883 1.02435229391816e-06 1.43175464812291e-06 225 2067.72727272727 1934 9.31229791701754e-08 222 1.56543995732087 -1.30449553277468 -1 9.76039915988297 222 1839 2663 3364 3292 737 940 1934 4178 2092 1484 1763 M11017 GO_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_DEVELOPMENT.html The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. 38/43 Gene Ontology BP GO:0060996 1.58768235020848e-07 3.37945378569079e-07 1860 1929.18181818182 1935 1.44334769526124e-08 1152 2.2055284059243 2.82385856116583 1 15.2900316256742 1860 2323 1842 1402 2136 2159 2541 1935 1152 1760 2111 1764 M15641 GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 137/250 Gene Ontology BP GO:0050777 1.18278909645994e-07 2.8354032281443e-07 1585 2111.45454545455 1935 1.07526287277309e-08 602 2.22004769989853 -1.97793868740024 -1 15.5740794703518 1584 1584 602 1935 1881 2461 3610 2970 3516 837 2246 1765 M11809 GO_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 31/55 Gene Ontology BP GO:0035456 1.18543424345954e-06 1.62469087918033e-06 825 2144.27272727273 1936 1.07766807473818e-07 683 1.79260911835048 -1.93414158094312 -1 11.0869779206804 824 3109 2427 3383 3360 1439 683 1385 3270 1771 1936 1766 M11765 GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOW_DENSITY_LIPOPROTEIN_PARTICLE_CLEARANCE.html The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 18/20 Gene Ontology BP GO:0034383 7.87342852772432e-08 2.33849999170963e-07 1940 2014 1937 7.15766255409185e-09 1428 2.47957742322752 2.59330074764933 1 17.6318779715753 1937 2455 1609 1784 1480 2458 2434 2411 1428 1486 2672 1767 M14169 GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. 18/21 Gene Ontology BP GO:0045986 1.36645186794787e-06 1.83653972893167e-06 1085 1659 1937 1.24222974242878e-07 573 2.45652431623942 2.32818865859209 1 15.0939458808015 1085 1977 1036 2106 3430 573 763 2252 2412 678 1937 1768 M14943 GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LONG_TERM_SYNAPTIC_POTENTIATION.html Any process that modulates the frequency, rate or extent of long-term synaptic potentiation. 21/29 Gene Ontology BP GO:1900271 1.24978406365415e-07 2.91344952313766e-07 1350 2193.45454545455 1937 1.1361673951385e-08 1218 3.25738249346899 3.04688237000294 1 22.8625799232933 1349 3158 1528 1937 1933 1773 2019 3520 1218 2446 3247 1769 M14774 GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. 262/403 Gene Ontology BP GO:0002831 2.56831705244269e-07 4.697683255822e-07 565 1663.90909090909 1938 2.33483395661127e-08 469 1.96517990622039 -1.77718875998568 -1 13.3081029825763 565 2146 1504 2265 2503 469 1097 1938 2872 2308 636 1770 M16283 GO_MYELOID_DENDRITIC_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_DENDRITIC_CELL_ACTIVATION.html The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 23/33 Gene Ontology BP GO:0001773 4.12669841803973e-07 6.79940783963842e-07 1815 1945.45454545455 1938 3.75154472010407e-08 922 1.87629438215156 -1.8760606248845 -1 12.3758767588256 1811 1922 2074 2140 2787 1816 2089 1157 922 2744 1938 1771 M11217 GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process. 55/75 Gene Ontology BP GO:0070228 1.25615879087463e-07 2.92245342696983e-07 3845 2179.72727272727 1939 1.14196260236268e-08 351 2.55899046753079 -2.78922929955778 -1 17.9328286031277 3843 351 832 808 1939 4347 4360 2701 1286 867 2643 1772 M16450 GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. 17/19 Gene Ontology BP GO:1900119 1.40813237109951e-06 1.88493668663004e-06 1840 2097.27272727273 1939 1.28012115671797e-07 939 2.65739406859665 3.34423453618329 1 16.3050267925668 1837 2875 1939 2193 3444 1380 1668 1165 2608 3022 939 1773 M10312 GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE.html Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. 74/108 Gene Ontology BP GO:0035019 1.05254815797623e-07 2.64711738989803e-07 1145 2107 1940 9.56862007575816e-09 869 2.14045106607408 2.42712204755 1 15.0805735989185 1143 3039 2307 869 1779 1621 951 4497 1940 3029 2002 1774 M16933 GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. 420/511 Gene Ontology BP GO:2001233 4.72053176478504e-08 1.98252330758246e-07 1880 2002.90909090909 1941 4.29139260552118e-09 954 1.96456063409962 2.13206218691356 1 14.09824517992 1877 1320 2084 1442 954 1204 2051 3132 1941 3275 2752 1775 M15341 GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of cell projection assembly. 197/259 Gene Ontology BP GO:0060491 3.22554620303833e-08 1.97691467186943e-07 4115 2455.27272727273 1942 2.9323147730272e-09 483 1.96093042895575 2.23827360620894 1 14.0745886541929 4114 1467 1546 726 489 4532 4229 3310 483 1942 4170 1776 M15925 GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus. 22/30 Gene Ontology BP GO:1902170 2.75592863334899e-07 4.95875326023698e-07 870 1921.54545454545 1942 2.50538998052982e-08 107 1.59776553523319 1.73446423785331 1 10.7583426300395 870 1942 2728 3913 2543 1119 107 612 4224 2177 902 1777 M15302 GO_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. 21/24 Gene Ontology BP GO:0055070 7.53196659160181e-08 2.28761361297149e-07 2050 2045.27272727273 1943 6.8472425904253e-09 734 2.05736886239519 -2.42760715985961 -1 14.6315779083618 2048 1943 2496 2543 1439 1728 1670 2870 734 3189 1838 1778 M16000 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 506/975 Gene Ontology BP GO:0050778 6.90077708376796e-08 2.20804208043575e-07 1030 2213.18181818182 1945 6.90077729806121e-09 1026 2.02744501718315 -2.00362479302893 -1 14.450763276143 1026 2596 4585 3640 1444 1308 2149 1166 3111 1945 1375 1779 M11518 GO_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_CHECKPOINT.html A cell cycle checkpoint that originates from the mitotic or meiotic spindle. 28/31 Gene Ontology BP GO:0031577 2.52050459166093e-06 3.16201344432416e-06 355 1830.63636363636 1946 2.29137043578828e-07 200 1.82712365184172 1.82240198348285 1 10.7323653707232 354 3434 3076 2888 3679 408 200 452 1946 3037 663 1780 M15937 GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS_VIA_THE_MULTIVESICULAR_BODY_SORTING_PATHWAY.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. 21/21 Gene Ontology BP GO:0043162 4.19225809624952e-07 6.86851300065106e-07 750 1871.72727272727 1947 3.81114445010421e-08 246 1.00756091412173 -0.923929389455068 -1 6.58864513754905 749 1947 3638 3174 2804 450 246 323 2885 3759 614 1781 M10305 GO_URETER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_URETER_DEVELOPMENT.html The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. 14/21 Gene Ontology BP GO:0072189 9.69491201098695e-07 1.36897077971044e-06 1945 2455.09090909091 1948 8.8135602575657e-08 1500 2.53924909638376 2.66077618191169 1 15.9557479522081 1944 2516 1587 2899 3258 1804 1862 3865 3823 1948 1500 1782 M10726 GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. 14/24 Gene Ontology BP GO:0070168 6.95484785124207e-08 2.21185701128363e-07 1915 1940.36363636364 1950 6.32258915555028e-09 935 2.74548891770876 2.94961951503904 1 19.6065074332194 1913 2521 1705 1967 1368 1875 2169 935 2949 1950 1992 1783 M13018 GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. 18/28 Gene Ontology BP GO:0045672 7.47938571467815e-08 2.28506774329596e-07 1485 2300.18181818182 1951 6.79944178996038e-09 1430 2.47807401489575 -2.79802058855597 -1 17.6479654689208 1483 2854 1564 3181 1430 1951 2471 1853 4206 1888 2421 1784 M13754 GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_NUCLEUS_LOCALIZATION.html The directed movement of the nucleus to a specific location within a cell. 19/29 Gene Ontology BP GO:0040023 1.57059524501268e-07 3.35923751724203e-07 3395 1882.09090909091 1951 1.42781396103507e-08 162 2.51127443270862 2.9406266369411 1 17.4323852710003 3395 1951 1624 1197 2122 3951 2192 992 162 2052 1065 1785 M12373 GO_GLYCOLIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 11/13 Gene Ontology BP GO:0019377 6.24956551357139e-07 9.45588698666089e-07 1895 2216.72727272727 1953 5.68142480808493e-08 1076 1.36192282788866 -1.63805644442787 -1 8.74159578181448 1894 1076 3139 3870 3036 1479 1553 1953 2352 2899 1133 1786 M13514 GO_REGULATION_OF_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ION_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of ion homeostasis. 188/303 Gene Ontology BP GO:2000021 5.37086368207998e-10 1.05445690770963e-08 2415 1737.63636363636 1953 4.88260334853744e-11 72 2.49817743228657 2.8312988570898 1 21.3937078245649 2415 1469 175 72 1012 1953 3321 4182 2254 128 2133 1787 M12014 GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH.html Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. 21/25 Gene Ontology BP GO:0046621 2.10719596453178e-08 1.97691467186943e-07 2065 1727 1957 1.91563271337714e-09 145 2.39563163990817 3.06835773902068 1 17.2197305417735 2061 813 1594 844 145 1957 2578 2735 1209 2842 2219 1788 M14664 GO_CELLULAR_RESPONSE_TO_KETONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_KETONE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus. 97/139 Gene Ontology BP GO:1901655 1.46973106977492e-07 3.2288284549871e-07 680 1651.36363636364 1957 1.33611924360156e-08 495 2.08865354272315 2.36169355284331 1 14.5184279320714 676 2649 1957 2005 2065 914 495 1033 2606 2153 1612 1789 M15603 GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum. 22/24 Gene Ontology BP GO:0070861 1.28994217746667e-07 2.97133710482793e-07 1485 1983.18181818182 1957 1.17267477554619e-08 473 1.56120766952296 -1.52203800974377 -1 10.8843547536666 1481 3147 3141 2536 1957 1615 601 852 3031 2981 473 1790 M10352 GO_CELLULAR_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 24/40 Gene Ontology BP GO:0098586 5.91084354647963e-07 9.05291929776382e-07 1570 1750.63636363636 1959 5.37349557688581e-08 448 1.7110617815902 -1.98313371502654 -1 11.0464882050199 1566 747 2224 1959 2997 1416 2336 2205 1252 2107 448 1791 M15534 GO_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERAD_PATHWAY.html The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. 91/99 Gene Ontology BP GO:0036503 7.7399524537299e-08 2.31007047897404e-07 790 2711.09090909091 1959 7.03632066003077e-09 788 1.21542470802805 -0.972762263526297 -1 8.5919984022759 788 4379 4056 4601 1469 1359 1255 1937 3615 4404 1959 1792 M10858 GO_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. 934/1187 Gene Ontology BP GO:0007010 3.82226140061864e-08 1.97691467186943e-07 2190 1988.09090909091 1961 3.82226146636222e-09 203 1.97798409472365 2.19372401205188 1 14.197975010596 2186 1181 4266 877 792 2737 2980 1961 1907 203 2779 1793 M15818 GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. 41/61 Gene Ontology BP GO:1901016 1.29638383656156e-07 2.98174690633759e-07 3245 2115.63636363636 1961 1.17853082995725e-08 482 2.45190346918807 2.76224142070179 1 17.1545711826282 3241 482 1428 1374 1961 3787 3158 3340 1146 792 2563 1794 M11979 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. 36/79 Gene Ontology BP GO:2000107 1.40148988775887e-07 3.12144068448248e-07 2150 1924.36363636364 1962 1.27408179730865e-08 1287 2.49425824888624 2.3824500502005 1 17.3993308996062 2150 2734 1536 1962 2033 2117 1944 2516 1287 1535 1354 1795 M14135 GO_DETECTION_OF_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_LIGHT_STIMULUS.html The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. 51/106 Gene Ontology BP GO:0009583 2.07202305072091e-08 1.97691467186943e-07 2885 1784.81818181818 1962 1.88365733657801e-09 136 2.47212689621907 2.48664822473327 1 17.7731875572198 2881 366 709 1698 136 2792 3720 2079 2394 896 1962 1796 M12106 GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_DESTRUCTION_COMPLEX_DISASSEMBLY.html The disaggregation of a beta-catenin destruction complex into its constituent components. 29/34 Gene Ontology BP GO:1904886 5.36064861297521e-07 8.35334829074804e-07 1295 1943.72727272727 1964 4.87331810834786e-08 483 1.66853592918474 2.05360733178902 1 10.8320298092032 1294 3121 3033 2047 2950 967 483 1964 1545 3147 830 1797 M14255 GO_CELLULAR_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCOSE_HOMEOSTASIS.html A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. 81/105 Gene Ontology BP GO:0001678 1.13941243034238e-07 2.7670595189891e-07 1240 2556.81818181818 1964 1.03582953577658e-08 827 1.64956727892953 1.6960444445827 1 11.5618468316301 1236 4385 3555 4043 1852 1239 827 1925 3154 3945 1964 1798 M11389 GO_RELAXATION_OF_CARDIAC_MUSCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELAXATION_OF_CARDIAC_MUSCLE.html The process in which the extent of cardiac muscle contraction is reduced. 21/30 Gene Ontology BP GO:0055119 4.47455284706195e-07 7.2317104541088e-07 1640 2373.63636363636 1965 4.0677761428509e-08 1637 2.276373334344 2.3121985046093 1 14.9731122107074 1817 2426 1781 2821 2844 1637 1965 4330 3046 1639 1804 1799 M12137 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 27/30 Gene Ontology BP GO:0051985 1.87329694007922e-05 2.09077732362404e-05 480 2090.45454545455 1965 1.70301171942434e-06 478 1.79544292737178 1.78512089088541 1 8.95473504181915 478 3128 3240 3427 4149 1133 939 737 1965 3243 556 1800 M15618 GO_DORSAL_VENTRAL_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. 24/35 Gene Ontology BP GO:0009950 1.38503213550379e-07 3.10580941036102e-07 2095 1561.81818181818 1965 1.25912020245444e-08 326 2.21698970771515 2.56596827048605 1 15.4578182840878 2091 791 2104 665 2020 2040 1319 1745 326 2114 1965 1801 M10598 GO_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_PROTEIN_TRANSPORT.html The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. 832/1034 Gene Ontology BP GO:0006886 4.0890761580048e-08 1.97691467186943e-07 1325 2696.09090909091 1966 4.08907623324724e-09 897 1.31557179595415 -1.27372868925431 -1 9.40530221554254 1323 4600 4250 4630 897 1042 1614 1966 3302 4606 1427 1802 M14081 GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). 14/24 Gene Ontology BP GO:0007191 2.32663368424829e-06 2.94180068826285e-06 2580 2161.27272727273 1966 2.11512376800767e-07 911 2.13037426515515 2.47902569841094 1 12.6044840502526 2579 974 1966 1522 3649 3105 1926 3108 2072 1962 911 1803 M10503 GO_MYELOID_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MIGRATION.html The movement of a myeloid leukocyte within or between different tissues and organs of the body. 85/150 Gene Ontology BP GO:0097529 1.26210621333792e-07 2.93042924683701e-07 1555 1880.90909090909 1967 1.14736935067548e-08 483 2.7601998602131 -3.05131783874767 -1 19.3482254405794 1551 2237 483 2483 1941 2154 2661 1029 3633 551 1967 1804 M15479 GO_NEGATIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. 272/388 Gene Ontology BP GO:0007162 8.92246313078501e-13 2.9654443533959e-11 100 1824.90909090909 1967 8.11133011889877e-14 99 2.45244539446433 2.65977430557369 1 27.7517147358233 3184 1373 99 100 331 2679 3357 2322 1967 145 4517 1805 M12886 GO_REGULATION_OF_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCRINE_PROCESS.html Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 35/62 Gene Ontology BP GO:0044060 3.61983341963643e-08 1.97691467186943e-07 4565 2369.54545454545 1968 3.29075770836037e-09 440 2.64828629077378 2.71213737530191 1 19.0477326395557 3604 2350 1300 1943 625 4563 4564 440 3286 1968 1422 1806 M14310 GO_RHYTHMIC_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_BEHAVIOR.html The specific behavior of an organism that recur with measured regularity. 19/32 Gene Ontology BP GO:0007622 2.93763812363077e-07 5.21711075925723e-07 1970 2089.63636363636 1968 2.67058046899158e-08 1083 2.20464616173338 2.5897276363983 1 14.8351688765822 2221 1945 1623 1963 2580 1967 1083 2299 1968 2055 3282 1807 M15074 GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. 44/87 Gene Ontology BP GO:0002275 3.34307281955266e-07 5.75909582724122e-07 895 1983.72727272727 1968 3.03915757050813e-08 455 1.75571719529685 -1.8761044063557 -1 11.7099406400836 894 1777 2076 1968 2658 1925 2617 455 2866 2752 1833 1808 M15417 GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. 153/211 Gene Ontology BP GO:1990267 3.92358793654278e-08 1.97691467186943e-07 3340 2088.72727272727 1969 3.56689818774362e-09 208 2.26681007308411 2.42273574807948 1 16.2876832052722 3340 1557 723 208 716 3415 3904 2395 1969 1275 3474 1809 M16502 GO_CELLULAR_RESPONSE_TO_DRUG http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DRUG.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. 84/137 Gene Ontology BP GO:0035690 2.30088733698676e-07 4.36090785295291e-07 980 1657.36363636364 1970 2.09171597966083e-08 329 2.21642411666125 2.40567890221566 1 15.1012549282328 976 2662 1970 2032 2409 419 329 1143 2904 2150 1237 1810 M11666 GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_MORPHOGENESIS.html The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 32/36 Gene Ontology BP GO:0003203 3.03021650457307e-06 3.72709420982778e-06 3435 2098.63636363636 1973 2.75474607119443e-07 740 2.97514474440516 3.43689250690616 1 17.3175256086543 3433 2743 922 761 3754 2447 1973 2985 1722 1605 740 1811 M13250 GO_POST_EMBRYONIC_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_MORPHOGENESIS.html The process, occurring after embryonic development, by which anatomical structures are generated and organized. 13/17 Gene Ontology BP GO:0009886 2.68866209875315e-08 1.97691467186943e-07 1975 2043.90909090909 1973 2.44423830146528e-09 316 2.71610098384767 2.68444916250597 1 19.5383842098902 1973 3541 1805 1884 316 2281 2689 2330 461 3638 1565 1812 M14868 GO_MAST_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a mast cell. 21/51 Gene Ontology BP GO:0002448 3.24562079849985e-07 5.62662949903867e-07 2245 2115.09090909091 1973 2.95056479756418e-08 646 2.57766141888486 2.56010765120258 1 17.273044948255 2242 1938 1343 1921 2642 1973 646 3007 1609 2445 3500 1813 M14998 GO_SPINDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINDLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. 87/99 Gene Ontology BP GO:0051225 2.98900078679357e-07 5.28814473800399e-07 1690 2039.54545454545 1974 2.71727381171842e-08 836 1.70892198293619 1.7373349215947 1 11.4631545845996 1690 1662 2880 2497 2589 2223 1690 1974 836 1971 2423 1814 M16616 GO_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_BACTERIUM.html Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. 160/539 Gene Ontology BP GO:0042742 1.31279768670405e-07 3.00411010867397e-07 1290 2029.09090909091 1974 1.19345251367467e-08 305 2.49837026642394 -2.53733944106034 -1 17.4730664855097 1288 3007 305 3283 1974 2093 2886 1438 3470 618 1958 1815 M12121 GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 31/43 Gene Ontology BP GO:0010743 2.9796016851411e-07 5.27552764115736e-07 1730 2268.81818181818 1976 2.70872917153438e-08 1210 2.20722759807403 -2.18190616135308 -1 14.8411523967225 1726 2374 1606 1976 2587 2408 3197 1947 3996 1210 1930 1816 M10798 GO_ENDOCARDIAL_CUSHION_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIAL_CUSHION_DEVELOPMENT.html The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. 45/53 Gene Ontology BP GO:0003197 1.0058301847906e-06 1.41095201984645e-06 3375 2071.90909090909 1977 9.14391495138155e-08 440 2.9313903579434 3.18103685589613 1 18.3957906166041 3373 440 519 1123 3279 2172 1977 3517 1890 773 3728 1817 M16835 GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXECUTION_PHASE_OF_APOPTOSIS.html Any process that modulates the frequency, rate or extent of execution phase of apoptosis. 30/35 Gene Ontology BP GO:1900117 9.86698096072477e-08 2.57032100060153e-07 4430 2657.45454545455 1977 8.96998309387097e-09 643 2.12254397525733 -1.53648192648211 -1 14.9827515207303 4427 643 1977 1779 1721 4590 4181 1631 2303 1934 4046 1818 M10929 GO_ACTIVATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_GTPASE_ACTIVITY.html Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. 85/108 Gene Ontology BP GO:0090630 2.56691193139019e-08 1.97691467186943e-07 2300 1651.27272727273 1978 2.33355632849124e-09 160 1.82283506631862 -1.59827901382613 -1 13.0754437275914 2297 160 2362 1535 279 1978 2074 2669 588 2642 1580 1819 M14592 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 40/80 Gene Ontology BP GO:0051926 5.68831035761124e-08 2.0634742747708e-07 1980 2326.45454545455 1978 5.17119136789814e-09 1162 1.65916431048547 1.69668341819885 1 11.8579306920931 1976 1803 2673 3666 1162 1670 1978 1972 3814 2306 2571 1820 M14701 GO_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_AGING.html An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). 91/113 Gene Ontology BP GO:0007569 2.63765819502273e-07 4.79040733077314e-07 1120 1791.72727272727 1978 2.39787137387364e-08 563 2.10371543562124 2.13392169187955 1 14.2349589594166 1120 2653 2230 2025 2520 1269 563 576 1868 2907 1978 1821 M11029 GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 84/108 Gene Ontology BP GO:0071322 1.066893211675e-07 2.66423092468559e-07 1075 2399.27272727273 1979 9.69902966740131e-09 507 1.74404683033899 1.84627859439257 1 12.2614897779559 1075 4382 3274 4425 1792 1015 507 1630 2865 3448 1979 1822 M11297 GO_CARBOHYDRATE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_PHOSPHORYLATION.html The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. 21/24 Gene Ontology BP GO:0046835 2.71355221675685e-08 1.97691467186943e-07 1650 2567.90909090909 1979 2.46686568202426e-09 328 1.20577915035286 -1.29302605655805 -1 8.61093256593349 1979 3740 3451 4503 328 1649 1724 1943 3774 3508 1648 1823 M12424 GO_NEGATIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 457/670 Gene Ontology BP GO:0051051 4.16275565731354e-08 1.97691467186943e-07 4215 2178.27272727273 1979 3.78432339643599e-09 201 2.10458726373696 2.26298891861336 1 15.1139718376851 4215 1288 622 201 774 2875 3332 4324 1979 720 3631 1824 M16487 GO_ADIPOSE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADIPOSE_TISSUE_DEVELOPMENT.html The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. 45/50 Gene Ontology BP GO:0060612 1.50931110111773e-07 3.27251843126785e-07 1920 1902.54545454545 1981 1.37210109514919e-08 700 2.17141910198332 2.32271104301103 1 15.0845416853321 1919 1776 2191 2590 2094 1311 700 1981 2431 2580 1355 1825 M12236 GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_FIBRIN_CLOT_FORMATION.html A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. 15/31 Gene Ontology BP GO:0072378 1.32192505316342e-07 3.01316750736611e-07 3860 2530.63636363636 1982 1.20175012054055e-08 367 3.12173304253036 2.87197836809267 1 21.8565461423079 3857 951 805 1830 1982 3872 4634 3972 367 980 4587 1826 M14992 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 1393/1992 Gene Ontology BP GO:0048585 4.93219539029601e-08 2.01774734543894e-07 1985 2088.36363636364 1982 4.93219549976548e-09 259 2.09696925128328 2.39385102123573 1 15.03876025631 2347 1153 4528 1681 1104 1981 2797 1982 2490 259 2650 1827 M16327 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. 29/37 Gene Ontology BP GO:0000083 1.57523408751826e-05 1.77256691879624e-05 270 1953.90909090909 1982 1.43204124231951e-06 270 1.53301844978357 1.62527862005989 1 7.74800263529029 270 2368 2725 1982 4111 786 497 1662 2996 1831 2265 1828 M11550 GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRAL_SPINAL_CORD_INTERNEURON_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. 5/15 Gene Ontology BP GO:0021521 3.6488339034957e-05 3.95850411586978e-05 1985 2248.63636363636 1983 3.64889381783013e-06 445 1.89639948540107 2.02052109580624 1 8.89723300386676 1983 2086 4310 1652 4280 1603 445 1761 2256 2619 1740 1829 M15625 GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_SPECIFICATION_INVOLVED_IN_PATTERN_SPECIFICATION.html The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. 5/15 Gene Ontology BP GO:0060573 3.6488339034957e-05 3.95850411586978e-05 1985 2273.90909090909 1984 3.64889381783013e-06 446 1.89639948540107 2.02052109580624 1 8.89723300386676 1984 2087 4565 1653 4281 1604 446 1773 2257 2622 1741 1830 M13300 GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. 953/1400 Gene Ontology BP GO:0014070 1.00097996075282e-10 2.22849749157076e-09 2035 1936.18181818182 1986 1.00097996079791e-11 98 2.32512180755441 2.36780103064653 1 21.5977217399664 2033 1183 4420 880 742 1208 2271 3451 1986 98 3026 1831 M10750 GO_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION.html A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 54/59 Gene Ontology BP GO:0006635 2.2054728128449e-08 1.97691467186943e-07 1970 2166.54545454545 1987 2.00497530450408e-09 175 1.40801613236772 -0.939133670688113 -1 10.0741537103126 1987 1730 3393 2831 175 1966 2181 1968 725 3865 3011 1832 M14322 GO_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULOGENESIS.html The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. 68/94 Gene Ontology BP GO:0001570 3.44725714257764e-07 5.89709098691682e-07 765 1874.63636363636 1987 3.13387062067325e-08 521 2.03133113240952 2.31231608540431 1 13.543386644899 762 2266 1680 1987 2680 669 1167 2928 3179 2782 521 1833 M11285 GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of EGF-activated receptor activity. 23/27 Gene Ontology BP GO:0007176 2.08966023960587e-08 1.97691467186943e-07 1990 1965.45454545455 1988 1.89969114495857e-09 141 1.45758785854279 -1.30846736883449 -1 10.4328141154477 1988 1912 2829 3334 141 1530 562 2684 2244 3097 1299 1834 M11957 GO_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_WOUND_HEALING.html The series of events that restore integrity to a damaged tissue, following an injury. 476/666 Gene Ontology BP GO:0042060 1.13749762137224e-11 3.04182553577301e-10 2860 1830.72727272727 1989 1.03408874670739e-12 124 2.36769352765117 2.55956482090463 1 24.2052482656211 2858 1278 124 893 305 3181 3906 2446 1989 160 2998 1835 M13744 GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 28/57 Gene Ontology BP GO:2000514 3.56027041892492e-07 6.06366700558479e-07 1515 2204.36363636364 1990 3.23660999553209e-08 1514 2.27464339763909 -2.65153671107318 -1 15.1494586659622 1514 1887 1838 1628 2696 2467 3309 1990 2479 2725 1715 1836 M12220 GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process. 16/20 Gene Ontology BP GO:1902991 4.22510624592428e-08 1.97691467186943e-07 2170 1851.72727272727 1992 3.8410057518796e-09 359 2.26338409931291 -1.91398443906571 -1 16.2628956653665 2166 1992 2264 1588 795 1941 2153 359 4100 2396 615 1837 M16196 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. 90/124 Gene Ontology BP GO:0033138 1.06160839444007e-07 2.65752334514745e-07 1945 2063.27272727273 1994 9.65098586970825e-09 1665 1.99189160195461 2.10845973197714 1 14.0223836281871 1704 1665 1942 2442 1788 1994 1943 2184 2104 2450 2480 1838 M16688 GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion. 113/187 Gene Ontology BP GO:0034111 8.23991744935683e-08 2.37677062514889e-07 2385 1846.45454545455 1995 7.49083432543284e-09 33 2.1788229480311 -2.18846063048866 -1 15.4629656318058 2382 33 742 1366 1531 2414 3395 3449 1995 485 2519 1839 M13923 GO_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. 25/54 Gene Ontology BP GO:0055078 1.44866210120787e-07 3.19401131586796e-07 3820 2104.36363636364 1996 1.31696563327252e-08 735 3.37539914628358 -3.08055561289128 -1 23.5495459429872 3816 735 775 1486 2053 4128 3457 2851 834 1017 1996 1840 M14720 GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY.html A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. 70/97 Gene Ontology BP GO:0060135 4.03237023881506e-08 1.97691467186943e-07 4580 2347.18181818182 1996 3.66579119338563e-09 222 2.29930430086891 2.10178528494012 1 16.5227848206706 4580 250 1359 222 743 4594 4238 2650 1996 1634 3553 1841 M15201 GO_MATURE_B_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION.html The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. 21/24 Gene Ontology BP GO:0002335 1.31518308963723e-07 3.00567137332123e-07 4350 2257 1997 1.19562106205478e-08 48 2.70398368158026 -2.27591759538632 -1 18.9197320035762 4350 764 1042 541 1977 4512 3514 2746 48 1997 3336 1842 M16698 GO_ASTROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DEVELOPMENT.html The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 22/39 Gene Ontology BP GO:0014002 1.03096220688752e-05 1.18125268373495e-05 2000 2230.72727272727 1997 9.3724276200537e-07 706 2.72794153291007 2.79400630179367 1 14.3943211666503 1997 3738 1944 2147 4037 1715 1442 706 2558 3295 959 1843 M10525 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 143/187 Gene Ontology BP GO:0014066 1.34409817952216e-07 3.04253649162657e-07 2335 1905.09090909091 1998 1.22190751058213e-08 806 2.35569471012075 2.63310214804924 1 16.4547318991909 2331 2192 806 1783 1998 1348 1501 2269 2685 1406 2637 1844 M15507 GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. 185/232 Gene Ontology BP GO:0030177 7.51297705215604e-08 2.28689428729205e-07 2325 2214.27272727273 1998 6.82997937156675e-09 1270 2.10517211042434 2.50046767427019 1 14.9744827817668 1616 3603 2321 1815 1433 2416 2321 1924 1270 3640 1998 1845 M10354 GO_RESPIRATORY_GASEOUS_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_GASEOUS_EXCHANGE.html The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. 47/68 Gene Ontology BP GO:0007585 1.34439179599919e-07 3.04253649162657e-07 1945 1968.63636363636 1999 1.22217443468477e-08 287 2.4440865018381 2.56055286262149 1 17.076399951173 1942 2301 1159 2061 1999 2878 3102 287 2319 1943 1664 1846 M13468 GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_MIGRATION_INVOLVED_IN_GASTRULATION.html The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). 14/22 Gene Ontology BP GO:0042074 6.12813909606004e-08 2.11467735746825e-07 3755 2149.90909090909 1999 5.57103569705496e-09 95 2.46467439860629 -1.62078336157024 -1 17.6414472619895 3752 1999 1891 292 1240 3156 2660 2762 95 1959 3843 1847 M15707 GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. 49/60 Gene Ontology BP GO:0045668 4.35929544137454e-08 1.97691467186943e-07 2880 1888.81818181818 2000 3.96299593432172e-09 290 2.27664276989583 2.37335299664553 1 16.3588245451886 2880 404 1527 290 836 2410 2690 2000 1253 2732 3755 1848 M11084 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_4_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway. 20/25 Gene Ontology BP GO:0034143 1.05148110566176e-06 1.46571048072024e-06 1040 2020.54545454545 2001 9.55892371102944e-08 1024 1.82258715691756 -2.31138021276455 -1 11.3622472216481 1039 1936 2345 2001 3301 2126 2301 1024 3027 1470 1656 1849 M14341 GO_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURON_APOPTOTIC_PROCESS.html Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. 46/69 Gene Ontology BP GO:0051402 4.69141174030027e-08 1.98252330758246e-07 4000 2145.81818181818 2001 4.26491985485705e-09 400 2.09560511147808 -1.5366346424044 -1 15.0462016673891 4000 400 1773 666 947 3614 3196 2001 712 2135 4160 1850 M15082 GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. 482/608 Gene Ontology BP GO:0042326 3.9500963056337e-08 1.97691467186943e-07 2005 1774.54545454545 2001 3.59099670596148e-09 489 1.91658593682186 2.24800615313632 1 13.7537482328189 2001 2122 1586 3093 721 489 2320 2172 2655 1807 554 1851 M16216 GO_MUSCLE_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_MIGRATION.html The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. 21/26 Gene Ontology BP GO:0014812 3.04031121659481e-07 5.35818478971489e-07 790 2096.27272727273 2001 2.76391966977603e-08 448 1.777676535512 1.76398079492198 1 11.9179353896774 786 3745 2599 2925 2601 1123 448 1112 4347 2001 1372 1852 M16408 GO_REGULATION_OF_NECROPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NECROPTOTIC_PROCESS.html Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. 16/18 Gene Ontology BP GO:0060544 1.3504960669572e-07 3.05242440541359e-07 3505 2093.72727272727 2001 1.2277237725991e-08 150 2.05167820365516 -2.68728442476807 -1 14.3134341690308 3503 904 1910 1175 2001 3159 2108 4030 150 1512 2579 1853 M13759 GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of a protein along a microtubule, mediated by motor proteins. 39/44 Gene Ontology BP GO:0098840 1.09130512325579e-07 2.69381577639745e-07 1555 2603.54545454545 2002 9.92095615808855e-09 1427 1.19821679136851 1.06691514099079 1 8.38244363499579 1554 3081 3684 4373 1814 1427 2002 1492 3616 3716 1880 1854 M15768 GO_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. 64/92 Gene Ontology BP GO:0048709 1.78033552445274e-07 3.6715029165863e-07 2455 1636.72727272727 2002 1.61848697138658e-08 240 2.81466805770225 3.39535272960408 1 19.4348369035277 2453 240 417 561 2211 2714 2888 2002 490 758 3270 1855 M12756 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production. 10/28 Gene Ontology BP GO:0032693 2.23456968477869e-05 2.47205248294704e-05 1985 2104.18181818182 2003 2.03144761993386e-06 439 3.23250539121909 -2.65386842537147 -1 15.9587806792481 1981 2555 1317 2499 4183 2003 2356 919 439 1566 3328 1856 M12867 GO_OVULATION_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION_CYCLE_PROCESS.html A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. 86/121 Gene Ontology BP GO:0022602 1.35293672797149e-07 3.05592941517056e-07 3375 2061.36363636364 2003 1.22994255561201e-08 181 2.75634954814844 3.1099687450324 1 19.2669018859226 3372 181 816 1193 2003 2686 2155 2549 1431 1908 4381 1857 M16836 GO_INTRACILIARY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACILIARY_TRANSPORT.html The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. 39/44 Gene Ontology BP GO:0042073 1.09130512325579e-07 2.69381577639745e-07 1555 2614.90909090909 2003 9.92095615808855e-09 1428 1.19821679136851 1.06691514099079 1 8.38244363499579 1555 3082 3685 4374 1815 1428 2003 1607 3617 3717 1881 1858 M12698 GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 291/381 Gene Ontology BP GO:0046822 9.2738414602671e-08 2.50341608610761e-07 2005 2388.63636363636 2005 8.43076531926819e-09 1654 1.84270527189113 2.01012485485355 1 13.0152762229191 2005 3311 3002 1817 1656 1654 1663 2882 1990 3461 2834 1859 M14497 GO_LIPID_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. 85/112 Gene Ontology BP GO:0046834 7.72609158878167e-08 2.30947065667097e-07 4095 2204.45454545455 2007 7.02371987282833e-09 159 2.27641071774022 -2.31442195034136 -1 16.1912531035411 4094 159 1174 266 1466 3959 3403 4314 598 2007 2809 1860 M14762 GO_RHYTHMIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHYTHMIC_PROCESS.html Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. 302/434 Gene Ontology BP GO:0048511 8.73361096128588e-08 2.45512816355666e-07 2415 1898.72727272727 2007 7.93964664363164e-09 786 2.21034958171255 2.48168826470224 1 15.6547405935188 2414 2139 1035 786 1580 2007 1741 2683 1136 2066 3299 1861 M11448 GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. 45/68 Gene Ontology BP GO:0003254 1.61323458672918e-07 3.42288213955809e-07 2010 1855.09090909091 2008 1.46657700456893e-08 450 2.72290828715102 3.14457693467433 1 18.8870507006634 2008 450 764 1912 2145 2497 3123 1054 2899 774 2780 1862 M13377 GO_GRANULOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_ACTIVATION.html The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 21/32 Gene Ontology BP GO:0036230 7.89210828307031e-07 1.15009947923338e-06 1265 2155.09090909091 2008 7.17464646747733e-08 521 2.13843434470007 -1.82344379147805 -1 13.5939271355796 1264 3475 2533 1970 3158 2008 2358 521 1407 3511 1501 1863 M11808 GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. 24/26 Gene Ontology BP GO:1902116 9.15702353412985e-08 2.49206886189644e-07 2980 2507.27272727273 2010 8.32456719570103e-09 758 1.45145642531308 1.4993115602358 1 10.2309101478706 2977 758 2915 1973 1642 2010 1659 4188 1938 3215 4305 1864 M14941 GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. 40/70 Gene Ontology BP GO:0009948 7.6837668278655e-08 2.30287553476591e-07 3190 2244.18181818182 2010 6.9852428147549e-09 1240 2.21224479597713 2.71551666659237 1 15.7346423826755 3188 2717 2010 1240 1460 2284 1510 4484 1706 2610 1477 1865 M13625 GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. 104/159 Gene Ontology BP GO:0046887 5.59231288874351e-08 2.05622555659363e-07 4530 2426.90909090909 2013 5.08392093717991e-09 98 2.55772369637088 2.95108676084364 1 18.3453408611849 4526 98 773 1399 1141 4539 4055 2808 2013 834 4510 1866 M10513 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 108/192 Gene Ontology BP GO:1903555 2.36543948916128e-07 4.42379017004319e-07 1180 1957 2014 2.15039976681211e-08 998 1.85375662284359 -1.93362243086037 -1 12.599332338643 1178 2214 2014 2348 2441 1167 3267 998 3628 1230 1042 1867 M10963 GO_POSITIVE_REGULATION_OF_LOCOMOTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LOCOMOTION.html Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. 517/658 Gene Ontology BP GO:0040017 1.8229877826734e-10 3.94528472222294e-09 1505 1819.36363636364 2017 1.82298778282294e-11 102 2.35155795921174 2.55010292265893 1 21.2150081403322 1503 1262 4271 691 299 2200 2391 2017 2299 102 2978 1868 M13338 GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleotide across a membrane. 13/13 Gene Ontology BP GO:1901679 1.23147318660306e-07 2.89250112936094e-07 2020 2043.72727272727 2017 1.11952114139643e-08 724 1.26757530757331 -1.35904918793696 -1 8.83192703674895 2017 2029 3037 3066 1920 1823 1949 724 2501 1332 2083 1869 M10801 GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. 31/45 Gene Ontology BP GO:0040020 1.29463634945748e-07 2.97920026410764e-07 2615 2006 2018 1.17694220513008e-08 636 2.08722301141883 1.98239464713835 1 14.5871243246108 2611 636 2018 641 1960 2164 1345 4045 1089 2465 3092 1870 M13063 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. 12/30 Gene Ontology BP GO:0002532 6.56564975930119e-07 9.87158427090118e-07 2050 2019.09090909091 2018 5.96877428976862e-08 280 2.66198483734397 -3.27699606019197 -1 17.14041531926 2046 2046 1700 280 3059 3397 4386 437 892 2018 1949 1871 M16780 GO_MITOTIC_CHROMOSOME_CONDENSATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CHROMOSOME_CONDENSATION.html The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. 15/15 Gene Ontology BP GO:0007076 6.79606524365593e-07 1.01613404815974e-06 445 1657.45454545455 2018 6.17824303913031e-08 320 1.71886880329892 1.78757211465728 1 11.0043517436915 441 2018 2895 3301 3076 584 320 366 2477 2201 553 1872 M12732 GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION.html Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. 72/101 Gene Ontology BP GO:0050805 1.26940042562478e-07 2.93418786906712e-07 2020 2019.18181818182 2019 1.15400045351747e-08 222 2.28694968594741 2.63592904653236 1 16.0101095670148 2019 222 1184 2255 1950 2233 2366 2874 1575 1777 3756 1873 M13142 GO_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_IMPORT.html The directed movement of the hexose monosaccharide glucose into a cell or organelle. 14/18 Gene Ontology BP GO:0046323 1.62976640596185e-07 3.44695594860932e-07 3405 2063.27272727273 2021 1.48160593335949e-08 38 2.28307962916166 -1.59639471993131 -1 15.8104758893379 3405 984 2021 1464 2153 2607 3360 1891 38 2956 1817 1874 M13821 GO_DISTAL_TUBULE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISTAL_TUBULE_DEVELOPMENT.html The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. 12/19 Gene Ontology BP GO:0072017 1.93120860165124e-07 3.88832264105722e-07 4590 2527.27272727273 2021 1.75564433743365e-08 222 2.46369276708823 2.75927269965082 1 16.9310499662873 4586 1005 1782 820 2273 4558 4401 1721 222 2021 4411 1875 M16292 GO_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 308/463 Gene Ontology BP GO:0009416 4.50954920233861e-08 1.97760774550163e-07 1585 1924.54545454545 2021 4.09959026797739e-09 775 1.86397575477545 1.85826693432481 1 13.3727978150981 1581 2137 2470 2575 898 775 1531 1767 2427 2988 2021 1876 M13154 GO_CELLULAR_RESPONSE_TO_CAMP http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CAMP.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. 47/64 Gene Ontology BP GO:0071320 3.59242763413535e-08 1.97691467186943e-07 2145 2244.36363636364 2022 3.26584335708808e-09 619 2.39757739348148 2.27634439422565 1 17.2338084208135 2144 2706 1755 2090 619 1696 1766 4152 2022 1944 3794 1877 M11267 GO_CELLULAR_COMPONENT_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_MAINTENANCE.html The organization process that preserves a cellular component in a stable functional or structural state. 23/26 Gene Ontology BP GO:0043954 8.20855149074436e-07 1.18985638898547e-06 2025 2266.18181818182 2023 7.46232232135241e-08 616 1.80887607291544 -1.72905619609832 -1 11.4526981743171 2023 2403 2675 1960 3175 1855 2007 616 3887 3096 1231 1878 M11381 GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BROWN_FAT_CELL_DIFFERENTIATION.html Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. 17/20 Gene Ontology BP GO:0090335 2.23762835846492e-06 2.84239277967165e-06 1810 2171 2023 2.03420966760769e-07 591 1.983190694264 2.14486514111615 1 11.7578033240162 1430 2483 2497 1808 3632 1545 591 1808 3048 3016 2023 1879 M16398 GO_APOPTOTIC_MITOCHONDRIAL_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_MITOCHONDRIAL_CHANGES.html The morphological and physiological alterations undergone by mitochondria during apoptosis. 76/85 Gene Ontology BP GO:0008637 7.31293526939354e-08 2.26202963946736e-07 1790 2155.72727272727 2026 6.64812319316363e-09 929 1.64218230580253 -1.84912817019555 -1 11.664690708912 1787 1690 3215 3169 1410 1230 2042 2026 2749 3466 929 1880 M10114 GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KIDNEY_DEVELOPMENT.html Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 13/25 Gene Ontology BP GO:0090185 1.64584705780427e-06 2.15965210376855e-06 2365 1903.09090909091 2030 1.49622571734908e-07 242 2.94876727334428 -2.19008655494506 -1 17.9171733107754 2365 2030 1577 789 3515 2725 2494 320 242 3227 1650 1881 M12557 GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. 35/42 Gene Ontology BP GO:2000279 3.58982943610307e-07 6.10507177126739e-07 605 2016 2030 3.26348183806387e-08 117 2.12317315520548 2.47722011245144 1 14.126341313612 601 3421 2746 3210 2700 711 117 1474 2030 3995 1171 1882 M15097 GO_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of ions within an organism or cell. 500/819 Gene Ontology BP GO:0050801 8.49359737704296e-11 1.93728963702848e-09 3770 1944.27272727273 2033 7.72145216124627e-12 126 2.29165888662227 -2.04745884578236 -1 21.4356777179381 3767 1267 151 1096 505 2033 3596 3223 2423 126 3200 1883 M14534 GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. 99/110 Gene Ontology BP GO:0031023 2.47537381673873e-07 4.57968762198223e-07 560 1934.27272727273 2035 2.25034008660036e-08 286 1.41958765899089 1.35332478424125 1 9.59890553019136 556 2226 3717 2866 2471 673 286 1719 2035 2714 2014 1884 M16107 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. 984/1448 Gene Ontology BP GO:0051241 1.19594759986307e-15 7.04397997742134e-14 2220 1831.81818181818 2036 1.19594759986307e-16 38 2.39129542942449 2.64404723768458 1 33.8295444163861 2219 1174 4593 374 569 1842 2392 2036 2156 38 2757 1885 M12468 GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CHEMOTAXIS.html Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. 13/24 Gene Ontology BP GO:0010758 5.1327725344618e-08 2.03397493965704e-07 2040 1987.09090909091 2037 4.66615695837583e-09 957 2.92666944124355 2.83203743843147 1 21.0228527101984 2036 2037 971 2330 1035 2611 2792 1466 3409 957 2214 1886 M14949 GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS.html The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. 28/37 Gene Ontology BP GO:0046716 8.56565381900444e-07 1.23354958897641e-06 2090 1913.45454545455 2037 7.78696104911417e-08 206 1.79800434767271 1.81944918235023 1 11.3527936533373 2090 1872 2357 1596 3198 2037 1731 2462 773 2726 206 1887 M13749 GO_POSITIVE_REGULATION_OF_URINE_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_URINE_VOLUME.html Any process that increases the amount of urine excreted from the body over a unit of time. 12/17 Gene Ontology BP GO:0035810 6.16278781040781e-08 2.12096536108192e-07 2040 2048.54545454545 2038 5.60253453003999e-09 1245 2.83294438621185 2.69917811418646 1 20.2903770014968 2192 2039 1315 3606 1245 2038 1536 1693 3210 1555 2105 1888 M10869 GO_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WOUNDING.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. 566/807 Gene Ontology BP GO:0009611 2.39036906006849e-12 7.22232937434979e-11 2260 1833.81818181818 2039 2.39036906007106e-13 72 2.51400454934733 2.71831204039107 1 27.4022665899374 2259 1238 4267 372 239 2350 3280 2039 1496 72 2560 1889 M10302 GO_MAMMARY_GLAND_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_MORPHOGENESIS.html The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 65/77 Gene Ontology BP GO:0060443 1.37743791972701e-07 3.09474584282461e-07 3560 1996 2040 1.25221636906321e-08 229 3.06165029943501 3.21289207277688 1 21.3953705042966 3556 2268 611 229 2014 2499 3010 2040 365 1061 4303 1890 M14914 GO_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 60/70 Gene Ontology BP GO:0010332 6.6683134537743e-07 1.00024701806614e-06 1365 2041.63636363636 2040 6.06210497725032e-08 785 1.99031835681983 2.07789900640278 1 12.7747572670687 1365 3654 2764 2427 3066 1070 785 1179 2702 2040 1406 1891 M13554 GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPHRIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. 104/118 Gene Ontology BP GO:0048013 2.17485055501735e-08 1.97691467186943e-07 4265 2054.27272727273 2042 1.97713688774294e-09 78 1.93495273824519 -1.37673832255287 -1 13.8866353632017 4262 78 2042 809 162 3595 3115 1525 519 2307 4183 1892 M12703 GO_CELLULAR_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. 71/154 Gene Ontology BP GO:0034754 1.21615776615919e-08 1.88626069531291e-07 3200 1996.63636363636 2043 1.10559797534737e-09 11 2.42578652591995 -2.44211749624625 -1 17.4912773901727 3197 1693 1071 2250 11 2712 3149 2043 1962 1325 2550 1893 M15741 GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. 165/214 Gene Ontology BP GO:0060759 2.41001985933647e-07 4.48732389175373e-07 930 1829.54545454545 2044 2.19092738485946e-08 653 1.82035878344023 -1.78948775786896 -1 12.3581348613874 929 2619 2226 1600 2455 653 1031 2567 3020 2044 981 1894 M14167 GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that increases the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 12/18 Gene Ontology BP GO:0060391 0.00467507034253402 0.00475789639190962 1765 2476.72727272727 2045 0.000425912243041158 1135 1.45033547662856 1.58405590832193 1 3.52232318517681 1762 3818 3090 1810 4642 1758 1176 2045 2510 3498 1135 1895 M15948 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of lamellipodium organization. 40/46 Gene Ontology BP GO:1902745 2.08327387812953e-07 4.0814624652365e-07 2055 1821.18181818182 2045 1.89388552309423e-08 833 1.88472784027769 -1.81187061757177 -1 12.8828710900548 2052 1796 2591 1085 2332 2080 1457 833 2045 2612 1150 1896 M12188 GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 17/21 Gene Ontology BP GO:0010893 8.1723289039649e-06 9.47566568406396e-06 1725 2220.81818181818 2047 7.42941751075612e-07 266 2.31665276585476 -2.321509499279 -1 12.446405745921 1723 3499 2762 2174 4411 1970 2047 266 1703 3384 490 1897 M10768 GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 58/104 Gene Ontology BP GO:0035725 1.41292266181338e-08 1.97691467186943e-07 3650 1953.63636363636 2048 1.28447515535246e-09 69 2.93466456821647 2.93148042172781 1 21.1197312753652 3649 268 224 69 2198 3383 3804 2048 1579 194 4074 1898 M15290 GO_RESPONSE_TO_EPINEPHRINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EPINEPHRINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 23/29 Gene Ontology BP GO:0071871 1.21244777981035e-07 2.87033193211408e-07 1460 2259.63636363636 2048 1.10222531511808e-08 873 1.78749909069361 2.11366412987967 1 12.5073709049175 1460 3153 2993 3213 1906 1286 873 1347 3837 2740 2048 1899 M10459 GO_POSITIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEMOPOIESIS.html Any process that activates or increases the frequency, rate or extent of hemopoiesis. 162/254 Gene Ontology BP GO:1903708 7.07478328272267e-08 2.23179434674635e-07 2050 2182.36363636364 2049 6.43162137294027e-09 949 1.96754015499054 -1.95493922922464 -1 14.0105780583015 1882 2185 1418 2852 1381 2296 3512 2049 3433 949 2049 1900 M12231 GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNOGLOBULIN_PRODUCTION.html Any process that modulates the frequency, rate, or extent of immunoglobulin production. 55/86 Gene Ontology BP GO:0002637 7.55592186117487e-07 1.10702955970865e-06 365 2267.81818181818 2049 6.86902223296817e-08 362 1.45168086532252 -1.45243389005254 -1 9.2179162192738 362 1734 3294 3400 3142 1417 2049 1259 3792 3030 1467 1901 M11540 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development. 19/23 Gene Ontology BP GO:2000696 8.11396557194701e-08 2.36555650415222e-07 2845 2077.18181818182 2051 7.37633261018504e-09 592 2.6946559339051 -1.97571738751771 -1 19.1565478896055 2843 848 1283 592 1512 3410 3752 3578 756 2051 2224 1902 M11622 GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 78/85 Gene Ontology BP GO:0007173 1.44457627308888e-07 3.1901345034089e-07 1385 2094.90909090909 2051 1.31325124358497e-08 1287 1.97198789800695 -2.23338835091716 -1 13.7123001129385 1385 2247 2325 1418 2051 2520 2915 1287 1775 3439 1682 1903 M13738 GO_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NIK_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). 94/119 Gene Ontology BP GO:0038061 0.000228540823850101 0.000237631386228943 540 2549.72727272727 2051 2.07785971477627e-05 537 1.70891391054706 -1.71422813108398 -1 6.57087254753324 537 4377 3814 2051 4462 1362 1453 2710 1711 4223 1347 1904 M16905 GO_IMMUNE_EFFECTOR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_EFFECTOR_PROCESS.html Any process of the immune system that can potentially contribute to an immune response. 447/940 Gene Ontology BP GO:0002252 1.15391953014512e-07 2.79769583911536e-07 1865 2119.63636363636 2051 1.0490178096993e-08 1092 2.05661313414072 -1.98208666586148 -1 14.4321325328268 1862 2598 1092 3034 1855 2051 2848 1902 2858 1114 2102 1905 M16100 GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. 97/119 Gene Ontology BP GO:0032273 3.57744206239886e-08 1.97691467186943e-07 3490 2257.72727272727 2052 3.25222010961092e-09 609 1.98832926951858 -1.90299243719235 -1 14.272824221415 3487 1638 2052 1760 609 2887 3094 3113 1589 1794 2812 1906 M16959 GO_FRUCTOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FRUCTOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. 22/26 Gene Ontology BP GO:0006000 5.92377826309405e-08 2.08691925686504e-07 2020 2150.27272727273 2052 5.38525311145388e-09 822 1.65743170599098 -1.68077679447609 -1 11.8366531151543 2018 822 2546 4109 1207 2052 2247 937 3678 2179 1858 1907 M14013 GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of organic acid across a membrane. 80/133 Gene Ontology BP GO:1903825 3.55992844740904e-08 1.97691467186943e-07 2920 2059.18181818182 2053 3.23629864092182e-09 164 2.39869658694267 2.55119145614885 1 17.2419059879387 2917 164 690 2053 604 3783 4068 3357 1095 408 3512 1908 M15996 GO_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_DUPLICATION.html The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 41/48 Gene Ontology BP GO:0051298 1.25829549999246e-06 1.7145774488559e-06 620 2039.90909090909 2053 1.143905654253e-07 306 1.43485419840047 1.42204388343414 1 8.81553963481194 616 3076 3704 2626 3380 817 306 539 2053 3447 1875 1909 M14196 GO_SEGMENT_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEGMENT_SPECIFICATION.html The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. 19/24 Gene Ontology BP GO:0007379 7.813745877808e-08 2.32910695512112e-07 2055 2164.09090909091 2054 7.10340559575369e-09 1136 2.11600182332795 2.59135700080377 1 15.0339585063866 2810 2467 2039 3101 1474 1564 1136 3293 2055 2054 1812 1910 M16057 GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT.html The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. 17/21 Gene Ontology BP GO:0060525 4.3110199788021e-07 7.00634857190575e-07 3220 1873.36363636364 2054 3.91910983960928e-08 288 3.46221851275854 3.68052286862415 1 22.8834391307575 3220 895 1072 288 2825 2417 1843 2834 556 2603 2054 1911 M16820 GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING.html Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. 20/23 Gene Ontology BP GO:1900025 4.30343722809979e-08 1.97691467186943e-07 2385 2020.27272727273 2055 3.91221573843607e-09 819 2.03032734334631 1.91732528950435 1 14.5766878819369 2383 1949 2055 2346 819 1452 3043 1703 1064 2259 3150 1912 M10481 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. 15/19 Gene Ontology BP GO:2001028 2.07063983545087e-05 2.30219525790989e-05 1155 2116.72727272727 2056 1.88241756778932e-06 792 2.80375813720844 3.58409840503679 1 13.9206151277228 1152 3215 1728 2185 4165 1389 792 2056 3240 2188 1174 1913 M11158 GO_L_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_TRANSPORT.html The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 42/67 Gene Ontology BP GO:0015807 1.87459041488859e-08 1.97691467186943e-07 4555 2078.09090909091 2056 1.7041731189652e-09 97 2.26754760858017 2.47933690058508 1 16.2930194079875 4553 431 1059 2056 97 3836 2842 2931 960 503 3591 1914 M12727 GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 53/61 Gene Ontology BP GO:0010660 1.28075822111455e-07 2.95750273094094e-07 2835 1808.09090909091 2056 1.1643257233414e-08 310 2.41643779267715 2.38043260923712 1 16.9140487649386 2835 367 1131 310 1952 2652 2106 2949 2056 1034 2497 1915 M12293 GO_ANDROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. 10/34 Gene Ontology BP GO:0006702 2.45618107317393e-07 4.55141797430437e-07 1790 2291.18181818182 2057 2.23289213399392e-08 850 3.63818215492325 -4.17982932017211 -1 24.7878132239933 1786 4301 1777 2512 2467 1781 1144 850 3849 2679 2057 1916 M16776 GO_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ASSEMBLY.html Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 37/40 Gene Ontology BP GO:0030032 5.3266587963419e-08 2.04903449305918e-07 4410 2564.09090909091 2057 4.84241720482856e-09 1086 1.90286290662992 -1.74077860585804 -1 13.6225023898786 4406 1786 2057 1713 1086 4337 3549 1917 3357 1390 2607 1917 M15961 GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_MORPHOGENESIS.html The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 21/32 Gene Ontology BP GO:0021692 1.45096536110919e-07 3.19514520834882e-07 2315 1894.54545454545 2058 1.31905950618607e-08 669 3.33346523724707 3.53361918067143 1 23.2550210635179 2311 2423 1148 948 2058 2730 2330 1784 669 2000 2439 1918 M12044 GO_HISTONE_EXCHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_EXCHANGE.html The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. 45/164 Gene Ontology BP GO:0043486 1.15141476259853e-06 1.58647701817321e-06 130 1906.81818181818 2060 1.04674124110483e-07 129 1.7280932155458 1.7132211989003 1 10.7031663758804 129 3380 2938 3063 3343 563 178 1300 2060 2577 1444 1919 M12163 GO_RESPONSE_TO_ENDOGENOUS_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOGENOUS_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. 1461/2167 Gene Ontology BP GO:0009719 8.00495532217668e-11 1.83483039970877e-09 2655 2060.81818181818 2060 8.00495532246502e-12 95 2.24465025451501 2.39958437219234 1 21.0508168665942 2655 1150 4349 370 403 2060 2978 3444 1647 95 3518 1920 M11053 GO_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 321/412 Gene Ontology BP GO:0051186 2.1572554879267e-08 1.97691467186943e-07 655 2399 2061 1.96114137189101e-09 159 1.60758868352914 -1.5350568510053 -1 11.5180972155397 655 3858 3824 4387 159 1414 1632 1456 3143 3800 2061 1921 M16717 GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANION_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of anion transport. 64/109 Gene Ontology BP GO:1903793 1.02177489837934e-07 2.61354764004912e-07 3405 2030.90909090909 2062 9.28886314395428e-09 263 2.50216317661985 3.05732686669867 1 17.6631006330222 3402 263 596 2062 1753 3704 3565 941 2966 495 2593 1922 M11996 GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 108/157 Gene Ontology BP GO:0002224 4.87180207607068e-07 7.74119465399828e-07 1395 1922.36363636364 2063 4.42891195900899e-08 1270 2.15631068401311 -2.40679485591126 -1 14.108613965719 1394 2213 1273 2099 2894 2063 2605 1270 1421 2415 1499 1923 M15299 GO_RETINA_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINA_HOMEOSTASIS.html A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. 68/134 Gene Ontology BP GO:0001895 5.51649032511241e-08 2.05617623085131e-07 3405 2179.18181818182 2065 5.01499133039835e-09 665 2.8592998572023 2.98091152494401 1 20.5217711248053 3403 1698 665 2065 1125 3034 3465 2448 2982 1104 1982 1924 M16435 GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity. 26/40 Gene Ontology BP GO:0035587 1.61923140389639e-07 3.43403998283041e-07 2285 1661.81818181818 2065 1.47202865734013e-08 452 3.32057805285075 3.66431572154101 1 23.0524580674544 2285 683 545 1128 2146 2513 2179 2357 1927 452 2065 1925 M11129 GO_REGULATION_OF_NOREPINEPHRINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOREPINEPHRINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. 10/23 Gene Ontology BP GO:0014061 3.21580827345249e-08 1.97691467186943e-07 3595 2257.36363636364 2067 2.92346210950815e-09 483 2.69528854794248 3.02039767004744 1 19.3878024716784 3595 2067 1510 2532 483 3435 3400 1557 1824 1563 2865 1926 M13587 GO_GOLGI_TO_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_ENDOSOME_TRANSPORT.html The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. 26/27 Gene Ontology BP GO:0006895 9.42226097403339e-06 1.08492403643102e-05 555 2193.18181818182 2067 8.56572848033374e-07 189 1.20790882792555 -1.2515165096954 -1 6.35882144275193 554 3724 3836 3469 4015 655 189 632 2067 4377 607 1927 M16306 GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of a defense response. 369/564 Gene Ontology BP GO:0031349 2.69537136266461e-07 4.87619088276766e-07 1130 2156.09090909091 2067 2.45033790263014e-08 1130 2.1197749847544 -2.10554897903993 -1 14.3268561711939 1130 3307 1164 2806 2530 2000 2478 1612 2895 1728 2067 1928 M12548 GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 9/13 Gene Ontology BP GO:0043650 1.05304411964351e-07 2.64711738989803e-07 1970 2079.18181818182 2068 1.0530441695441e-08 67 2.57522382178726 2.03891407891634 1 18.1667428819682 1968 2068 4374 1342 1860 2149 1882 2136 67 2427 2598 1929 M10393 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM.html A process in which an organism has a negative effect on the functioning of the second organism's cells. 10/82 Gene Ontology BP GO:0044364 8.79834302564165e-08 2.4552368046601e-07 2070 2480.36363636364 2069 7.99849397955376e-09 897 3.10134208547132 -3.33441278196362 -1 22.0106960703522 3795 2069 1462 2710 1593 3879 3829 1193 897 2069 3788 1930 M10800 GO_RESPONSE_TO_DIETARY_EXCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DIETARY_EXCESS.html The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. 18/30 Gene Ontology BP GO:0002021 3.69322552239174e-07 6.25121075143281e-07 1935 2246.09090909091 2069 3.35747831126183e-08 758 2.57790883437683 2.85212202038673 1 17.1475249998883 1931 2844 1671 3120 2716 1505 758 3947 1832 2314 2069 1931 M13484 GO_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 377/583 Gene Ontology BP GO:0052547 2.22750808186871e-08 1.97691467186943e-07 1850 1795.54545454545 2070 2.02500736765664e-09 181 2.34027605967181 2.64862842654825 1 16.8192229063536 1850 2133 263 2070 181 1852 2296 2603 2921 928 2654 1932 M11402 GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEIOTIC_NUCLEAR_DIVISION.html Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. 10/17 Gene Ontology BP GO:0045835 1.15812373570769e-06 1.59289084902391e-06 1120 1983.90909090909 2071 1.05284031397046e-07 94 1.69088530833981 1.44678445372413 1 10.4670817430077 1117 2071 2763 3375 3348 721 94 1470 2814 3199 851 1933 M11449 GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 10/12 Gene Ontology BP GO:0046349 1.22285488965094e-05 1.39288709952163e-05 1015 2270.81818181818 2072 1.11169244259887e-06 516 1.14511791877861 -1.12664674165916 -1 5.88828075283068 1011 2072 3230 3889 4064 1105 516 1001 4221 2678 1192 1934 M11320 GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_OF_OTHER_ORGANISM.html Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 10/82 Gene Ontology BP GO:0031640 8.79834302564165e-08 2.4552368046601e-07 3800 2479.90909090909 2074 7.99849397955376e-09 898 3.10134208547132 -3.33441278196362 -1 22.0106960703522 3796 2070 1463 2711 1594 3880 3830 1174 898 2074 3789 1935 M11935 GO_REGULATION_OF_GLOMERULAR_FILTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLOMERULAR_FILTRATION.html Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. 8/13 Gene Ontology BP GO:0003093 1.02782320701768e-07 2.62052678479631e-07 1345 2266.18181818182 2074 1.02782325455661e-08 707 2.14101418822633 2.41874713361841 1 15.0947021082337 1344 3568 4333 3657 1846 2074 707 1206 2107 2807 1279 1936 M11852 GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation. 10/16 Gene Ontology BP GO:0048712 1.2932735107053e-06 1.75184909616063e-06 2500 1969.63636363636 2076 1.17570388268984e-07 290 4.08858683007597 4.90241195696361 1 25.2876551560524 2500 2559 1411 1613 3399 2754 3408 358 290 2076 1298 1937 M10180 GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. 130/154 Gene Ontology BP GO:0002244 1.49000769974598e-07 3.25493231310707e-07 915 1902.45454545455 2077 1.35455254605516e-08 914 2.33719833440973 2.90096293118073 1 16.2507238643748 914 2634 1023 2109 2077 1319 1541 2405 3333 2301 1271 1938 M14154 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus. 56/69 Gene Ontology BP GO:0060761 1.61086722582457e-06 2.12092959868753e-06 1370 2263.18181818182 2077 1.46442582302063e-07 696 1.99747824147976 -1.77629983901996 -1 12.1174445507183 1370 1732 2041 2308 3499 1085 696 4139 3810 2138 2077 1939 M11916 GO_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CHEMOTAXIS.html The movement of a leukocyte in response to an external stimulus. 92/167 Gene Ontology BP GO:0030595 4.15429033831989e-07 6.82858990575346e-07 1225 1945.72727272727 2078 3.77662829343679e-08 516 2.7425918017938 -2.90844593882743 -1 18.1366129310438 1221 2652 516 2078 2793 1949 2462 1291 3596 636 2209 1940 M10838 GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). 15/33 Gene Ontology BP GO:0042744 3.07839963836517e-07 5.4031661702426e-07 1515 1985.90909090909 2079 2.79854551737934e-08 617 2.16860018221861 -2.18516210384602 -1 14.5551474570674 1513 2013 1864 2079 2611 1226 617 2515 2246 2687 2474 1941 M12973 GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. 10/13 Gene Ontology BP GO:0060576 4.32179541318236e-06 5.18014272476495e-06 3285 2277.18181818182 2079 3.92891263924304e-07 1097 2.3871642436242 2.42194181117179 1 13.5043585291909 3282 2064 1956 2332 3858 2915 1927 1147 1097 2079 2392 1942 M12594 GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. 184/241 Gene Ontology BP GO:0071453 2.11913445118012e-07 4.12738911734663e-07 840 2004.90909090909 2080 1.92648605027661e-08 332 2.12714633389556 2.3224699337236 1 14.5432895626851 840 3870 1916 2659 2346 332 767 2080 2639 3285 1320 1943 M10581 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. 31/36 Gene Ontology BP GO:2000108 1.38933717160305e-07 3.11096528367132e-07 3855 2313.09090909091 2081 1.26303387212914e-08 649 2.53964217204876 -2.32122220149254 -1 17.7219772609751 3854 649 1225 1446 2024 3188 2312 2913 2081 1209 4543 1944 M14703 GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. 5/18 Gene Ontology BP GO:0045653 3.21840699121558e-07 5.59613143876162e-07 2335 1926.18181818182 2082 3.21840745733213e-08 87 2.69137690007051 -4.02813055355239 -1 18.0469038652691 2332 1125 4513 747 2691 2409 2082 658 87 2621 1923 1945 M16547 GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_SEGREGATION.html Any process that modulates the frequency, rate or extent of sister chromatid segregation. 75/81 Gene Ontology BP GO:0033045 5.36512383912744e-06 6.35537709354887e-06 350 2121.81818181818 2082 4.87739720278201e-07 350 1.74567516435308 1.81688907886198 1 9.67771957728124 350 2669 3602 2445 3902 1058 1069 1463 2082 3434 1266 1946 M10225 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding. 27/34 Gene Ontology BP GO:2000678 4.59014528159863e-05 4.95084515421382e-05 1215 2277.09090909091 2083 4.17294641322671e-06 838 2.04667119066682 -1.69171452204037 -1 9.39663226184289 1214 3436 2083 2874 4296 1525 2045 1573 2959 2205 838 1947 M14531 GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. 14/25 Gene Ontology BP GO:0035590 5.62252230051557e-08 2.06159151018904e-07 3160 2249.36363636364 2083 5.11138404019084e-09 605 3.40053794775741 -2.84798778948798 -1 24.4235621095588 3159 954 738 2083 1146 2912 3227 3918 2080 605 3921 1948 M14120 GO_SOCIAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOCIAL_BEHAVIOR.html Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. 41/65 Gene Ontology BP GO:0035176 3.82063889242346e-07 6.4062820779987e-07 4050 2370.54545454545 2084 3.47330868721493e-08 493 2.3196899921294 2.25760334650845 1 15.39195544322 4046 493 1325 1187 2741 3514 4594 2084 1899 1353 2840 1949 M15190 GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. 21/45 Gene Ontology BP GO:0042743 1.42879742529431e-07 3.16731511190778e-07 1090 1952.45454545455 2084 1.2989068346255e-08 381 2.08397516982631 -1.89523677263318 -1 14.5044430274421 1089 2425 2035 2084 2043 1127 381 2812 2198 2447 2836 1950 M12168 GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEIOTIC_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. 18/24 Gene Ontology BP GO:0051446 1.50082535896447e-07 3.26629578824212e-07 2530 2075.45454545455 2085 1.36438678304526e-08 986 1.92398507908253 -1.94516360979931 -1 13.354481319807 2526 1981 2216 1048 2085 2403 3462 1358 986 2760 2005 1951 M10913 GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. 13/16 Gene Ontology BP GO:0033240 9.56158949363597e-08 2.53253228137632e-07 3230 2516.45454545455 2086 8.6923544629087e-09 94 2.72784936361114 -1.09364430391992 -1 19.3067104761011 3474 3228 2086 1775 1691 4061 4641 1921 94 3228 1482 1952 M15978 GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway. 20/24 Gene Ontology BP GO:0010640 3.08167739146289e-08 1.97691467186943e-07 2630 2080.81818181818 2086 2.80152494057262e-09 439 2.60794495495439 3.07553352347173 1 18.7558557781857 2627 2435 1993 1244 439 2728 2804 3988 691 1854 2086 1953 M15713 GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-2 production. 50/66 Gene Ontology BP GO:0032663 1.08562749062015e-07 2.6865217663753e-07 4210 2595 2087 9.86934131083901e-09 372 2.00047310770747 -2.17578984023511 -1 14.0731065442041 4210 372 1757 1900 1810 4171 4129 2865 2087 1127 4117 1954 M10637 GO_SEROTONIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEROTONIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. 12/21 Gene Ontology BP GO:0042428 5.53925748115325e-07 8.5799484220393e-07 3550 2459.81818181818 2092 5.03568988713866e-08 747 2.77392826819541 2.21418663731096 1 18.048294215689 3550 2049 1817 2092 2967 3450 3500 3186 747 2014 1686 1955 M10176 GO_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. 268/308 Gene Ontology BP GO:0007059 5.89275206047488e-07 9.03425876026017e-07 35 1848.72727272727 2095 5.35704876260277e-08 33 1.51423364190214 1.64107618132529 1 9.7642348202359 33 3313 3850 2759 2995 403 379 1177 2235 2095 1097 1956 M10304 GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. 20/25 Gene Ontology BP GO:1900015 9.28087846235895e-08 2.50341608610761e-07 2110 1929 2095 8.4371625944367e-09 1120 2.84113412152602 -2.20364380983588 -1 20.128593504264 2107 2833 1492 2095 1657 2161 2263 2437 1120 1850 1204 1957 M12933 GO_ONE_CARBON_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_COMPOUND_TRANSPORT.html The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/11 Gene Ontology BP GO:0019755 1.4159368152947e-07 3.14479904609368e-07 2310 2191.18181818182 2095 1.41593690551418e-08 1520 4.47869612961682 -4.54555273195043 -1 31.3166112031689 2307 2569 4395 1684 2113 2249 1989 1623 1559 1520 2095 1958 M10609 GO_SODIUM_ION_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_ION_EXPORT.html The directed movement of sodium ions out of a cell or organelle. 10/15 Gene Ontology BP GO:0071436 3.69291686142008e-06 4.47944268930856e-06 3465 2405.63636363636 2096 3.35720278214512e-07 1087 3.25720558962454 2.9864686347228 1 18.6893413015059 3463 1087 1247 2096 3809 2629 2246 2011 1901 1560 4413 1959 M12303 GO_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. 305/465 Gene Ontology BP GO:0019216 3.5260216962969e-08 1.97691467186943e-07 2980 2146.63636363636 2096 3.20547432073615e-09 594 2.15980440703859 -1.79869759569978 -1 15.5134778568425 2976 2604 1102 1573 594 2257 3436 3404 2096 1595 1976 1960 M13815 GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound. 109/135 Gene Ontology BP GO:0046434 2.76594991599529e-08 1.97691467186943e-07 1950 2211.90909090909 2096 2.51449995524563e-09 346 1.71273796214931 -1.66142707657331 -1 12.278871265174 1947 1625 2838 4082 346 2324 2736 1988 2327 2096 2022 1961 M13145 GO_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other. 121/132 Gene Ontology BP GO:0007062 1.38074782194593e-06 1.85307747779475e-06 5 1841.90909090909 2097 1.25522608047408e-07 1 1.61038346269361 1.61967541803975 1 9.84916873585466 1 3619 3408 2794 3435 296 86 1267 2097 2220 1038 1962 M13330 GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. 32/61 Gene Ontology BP GO:0006775 4.64640460097764e-08 1.97800744927456e-07 4460 2567.36363636364 2097 4.22400427191801e-09 921 3.23811315430721 3.0480329272232 1 23.3143979662385 4459 1843 921 2097 938 4280 3614 4439 1015 1347 3288 1963 M13427 GO_ENDOTHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 113/132 Gene Ontology BP GO:0003158 1.87953373023056e-06 2.42525525423261e-06 1740 2418.36363636364 2097 1.70866848725558e-07 1304 2.33174919891855 2.66078690281638 1 14.0176441202754 1739 3883 1559 3041 3574 1514 2097 1304 3040 1865 2986 1964 M16620 GO_ALCOHOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALCOHOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. 63/86 Gene Ontology BP GO:0046164 3.20489758821545e-08 1.97691467186943e-07 2100 2149.72727272727 2097 2.91354330445771e-09 479 2.10803690910861 -2.23177383173583 -1 15.1389306459017 2097 1706 1305 3594 479 1835 2970 2750 3073 1650 2188 1965 M16433 GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION.html The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. 18/22 Gene Ontology BP GO:0060900 9.01617963596838e-08 2.47798486982639e-07 3775 2256.45454545455 2098 8.19652727770472e-09 523 2.75857764703602 -2.23848820959814 -1 19.5536208085492 3771 896 1506 2358 1625 4015 4371 2098 2167 1491 523 1966 M13303 GO_TRANSEPITHELIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSEPITHELIAL_TRANSPORT.html The directed movement of a substance from one side of an epithelium to the other. 10/18 Gene Ontology BP GO:0070633 5.77452020428802e-07 8.89107958654936e-07 1620 2355.45454545455 2099 5.24956519997654e-08 1173 1.96988485272684 -2.33056436443077 -1 12.7511935743803 1619 2060 2099 2290 2984 1746 1852 4127 3277 2683 1173 1967 M15395 GO_KETONE_BODY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BODY_METABOLIC_PROCESS.html The chemical reactions and pathways involving ketone body. 9/14 Gene Ontology BP GO:1902224 1.39426395706164e-07 3.11452674737746e-07 3330 2549.72727272727 2099 1.39426404454039e-08 676 2.47619513257103 1.89845145667971 1 17.2750815790232 3326 1092 4551 3596 2099 2925 1964 1883 676 1823 4112 1968 M11614 GO_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_KETONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 62/102 Gene Ontology BP GO:0042180 6.84599258647225e-08 2.20507296091218e-07 1860 2216.81818181818 2103 6.22362981773351e-09 1349 1.87431733513357 -1.98975350314623 -1 13.3519746003615 1858 2273 2465 3324 1349 1569 2103 2060 2480 3142 1762 1969 M13914 GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOMEMBRANE_SYSTEM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. 556/639 Gene Ontology BP GO:0010256 2.4476988986163e-08 1.97691467186943e-07 2890 2280.27272727273 2104 2.44769892557683e-09 320 1.79684611891602 -1.46407447564623 -1 12.8874089923972 2889 1246 4460 1324 320 2104 3208 3497 1405 2042 2588 1970 M13898 GO_NEGATIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_DEATH.html Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 939/1365 Gene Ontology BP GO:0060548 5.02038500530844e-08 2.02375063519002e-07 2585 2465.90909090909 2105 5.02038511872764e-09 1126 2.06498650503982 2.18964675937478 1 14.8047904044057 2582 2105 4458 1397 1126 2084 2444 3788 1971 1559 3611 1971 M14988 GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTROGEN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. 44/66 Gene Ontology BP GO:0071391 1.53586767015278e-07 3.31158121836001e-07 2170 2183.54545454545 2105 1.39624343397731e-08 1197 2.41622690727544 2.18559959666964 1 16.7844995343192 2170 1762 1202 1547 2105 2811 2475 3317 1686 1197 3747 1972 M11508 GO_REGULATION_OF_HAIR_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HAIR_CYCLE.html Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. 22/27 Gene Ontology BP GO:0042634 5.27353847486719e-07 8.25076480281003e-07 3225 2215.09090909091 2106 4.79412703542544e-08 419 3.12919536989308 3.45904996103565 1 20.431668817456 3222 1932 932 776 2939 3407 3377 2106 419 1447 3809 1973 M11101 GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. 11/21 Gene Ontology BP GO:0042136 3.79859393658472e-07 6.38542542880373e-07 2725 2130.63636363636 2107 3.45326781132989e-08 466 3.75011149198793 -3.39563394634199 -1 24.9587757396503 2722 3560 1420 2107 2733 2024 466 813 3606 2334 1652 1974 M15186 GO_ENDOCRINE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_SYSTEM_DEVELOPMENT.html Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. 85/165 Gene Ontology BP GO:0035270 9.24369090714972e-08 2.50183514628907e-07 2470 2044.90909090909 2107 8.40335572321803e-09 276 2.22961741503282 2.4868081407144 1 15.7724961863111 2466 2241 1434 276 1651 2819 2107 3738 1340 1845 2577 1975 M14274 GO_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_SECRETION.html The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 40/87 Gene Ontology BP GO:0050663 7.68598335569816e-07 1.12475417364862e-06 1855 2514.72727272727 2108 6.98726003717885e-08 1281 2.03680858287681 -2.02628782624712 -1 12.9637957373214 1852 3394 1911 2971 3145 2108 2756 1281 4267 1984 1993 1976 M13963 GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. 24/29 Gene Ontology BP GO:0045683 7.83592014618044e-07 1.14296352477046e-06 4090 2187.45454545455 2110 7.12356630651426e-08 144 3.28016490164656 -3.13277783163484 -1 20.9218077340326 3630 736 801 613 3156 4088 4088 2663 144 2110 2033 1977 M15281 GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT.html Any process that modulates the frequency, rate or extent of actin filament-based movement. 44/71 Gene Ontology BP GO:1903115 1.54411749491876e-07 3.32167300224549e-07 2950 1896.63636363636 2110 1.40374327572363e-08 349 2.56977579984702 3.20174954583512 1 17.8546606302668 2948 436 794 1490 2110 3259 3602 467 2554 349 2854 1978 M16456 GO_EMBRYONIC_PLACENTA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_MORPHOGENESIS.html The process in which the embryonic placenta is generated and organized. 23/31 Gene Ontology BP GO:0060669 5.29541680351923e-07 8.27108908585934e-07 2110 2530.54545454545 2110 4.81401643466412e-08 1011 2.13922414880891 2.16313080727126 1 13.929535069623 4248 1919 2110 1228 2943 4294 3705 2109 1011 1941 2328 1979 M16219 GO_SINGLE_ORGANISM_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CATABOLIC_PROCESS.html A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism. 868/1233 Gene Ontology BP GO:0044712 1.70748912533813e-08 1.97691467186943e-07 2315 2206.81818181818 2113 1.70748913845796e-09 98 2.04015137618726 -1.73582515011263 -1 14.6477665364577 2315 1202 4605 2052 98 1639 2544 3632 2113 1274 2801 1980 M13557 GO_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STAT_CASCADE.html An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with activation of STAT proteins by kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 46/85 Gene Ontology BP GO:0097696 5.09319667353018e-08 2.02998167617902e-07 1030 1854.18181818182 2114 4.63017890131114e-09 452 1.9417574337239 -1.74075774682988 -1 13.9117603124827 2114 452 2241 1989 1027 2253 2805 2207 1027 1620 2661 1981 M16204 GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication. 60/68 Gene Ontology BP GO:0008156 1.56010044112192e-07 3.3498603380435e-07 320 2229.81818181818 2114 1.4182732288676e-08 175 1.50723826307713 1.65347729069153 1 10.4194757902029 319 3367 3736 3791 2114 776 175 1589 2948 3962 1751 1982 M14003 GO_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JAK_STAT_CASCADE.html Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. 46/85 Gene Ontology BP GO:0007259 5.09319667353018e-08 2.02998167617902e-07 1030 1864.09090909091 2115 4.63017890131114e-09 453 1.9417574337239 -1.74075774682988 -1 13.9117603124827 2115 453 2242 1990 1028 2254 2806 2306 1028 1621 2662 1983 M15104 GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION.html The process in which epiblast cells acquire specialized features of neuroepithelial cells. 74/104 Gene Ontology BP GO:0060563 1.56281185607746e-07 3.35145096394387e-07 3275 1879.45454545455 2116 1.42073815190435e-08 196 2.96054169150697 3.07623991499693 1 20.574494174766 3272 196 414 497 2116 2945 2825 3065 947 540 3857 1984 M10255 GO_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 56/64 Gene Ontology BP GO:0010883 1.22285021952923e-07 2.88167782170068e-07 1265 2114.72727272727 2117 1.1116820795457e-08 720 2.00204751081544 -1.92939043751653 -1 14.0184678875001 1262 2693 2117 3654 1914 1139 2335 2224 4138 1066 720 1985 M16873 GO_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYOBLAST_FUSION.html A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. 25/49 Gene Ontology BP GO:0007520 4.75054617665403e-07 7.58294729330059e-07 2460 1806.45454545455 2117 4.31867927496217e-08 108 3.14756621637814 3.80328669803608 1 20.6768020810695 2457 696 678 108 2881 2673 3554 3311 376 1020 2117 1986 M10671 GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. 62/82 Gene Ontology BP GO:0051148 1.56422184417439e-07 3.35252152968375e-07 3810 2398.63636363636 2118 1.42201995944739e-08 819 2.27188705341019 2.64582632457752 1 15.7619921312685 3807 1708 1200 819 2118 3241 3185 3806 1851 1365 3285 1987 M14565 GO_HAIR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HAIR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hair cell. 41/64 Gene Ontology BP GO:0035315 3.67932008415263e-07 6.24090805343792e-07 4200 2531.90909090909 2119 3.34483699953542e-08 1059 2.37686921977964 -2.49459434930678 -1 15.803283597725 4196 1788 1813 1059 2710 4382 4502 1472 1228 2119 2582 1988 M11435 GO_OXALOACETATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALOACETATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle. 11/12 Gene Ontology BP GO:0006107 6.15963527220733e-07 9.35709530577235e-07 1335 2053.63636363636 2120 5.59966999709434e-08 740 1.4034005371994 -1.69358485680976 -1 9.01817614085643 1335 2540 3164 2857 3022 1461 1218 740 2120 2897 1236 1989 M12931 GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. 27/35 Gene Ontology BP GO:0071634 2.85583163134649e-07 5.10298947029771e-07 1730 2217.81818181818 2120 2.59621091096688e-08 531 2.27468654822863 2.91269295715536 1 15.3336474060576 1730 3716 2120 2009 2561 2965 2017 531 2181 2571 1995 1990 M15414 GO_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_INVAGINATION.html The infolding of a membrane, resulting in formation of a vesicle. 41/170 Gene Ontology BP GO:0010324 1.28576206866672e-08 1.92368196318529e-07 3110 2159.81818181818 2120 1.16887461471018e-09 20 2.21373202000095 -2.13827235019219 -1 15.9319761860563 3110 1782 1538 1898 20 2876 3373 3064 2450 2120 1527 1991 M10337 GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_5_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-5 production. 16/42 Gene Ontology BP GO:0032674 1.80859860377292e-08 1.97691467186943e-07 3565 2241.90909090909 2122 1.64418056240111e-09 82 2.49434441925272 -3.02722651359414 -1 17.9339353549504 3565 972 1748 2122 82 4234 3930 2311 1163 1500 3034 1992 M12647 GO_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BACTERIUM.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. 455/948 Gene Ontology BP GO:0009617 1.91886681981806e-08 1.97691467186943e-07 1890 1987.54545454545 2123 1.74442439686786e-09 191 2.20674526867797 -2.21785250513517 -1 15.8531034812057 1886 2123 233 2241 1412 2448 3657 1866 3259 191 2547 1993 M12955 GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. 151/264 Gene Ontology BP GO:1903707 3.76623968729887e-07 6.34249484799191e-07 695 2060.63636363636 2123 3.42385484731983e-08 695 1.78169104834076 -1.90676973600107 -1 11.8042702407919 695 2625 2204 3491 2728 1371 2123 705 3662 1860 1203 1994 M15905 GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of alcohol biosynthetic process. 44/77 Gene Ontology BP GO:1902930 3.72041341001476e-07 6.28579651299879e-07 1735 2260.27272727273 2124 3.38219458106627e-08 1139 2.70628712516699 -2.36767649282265 -1 18.0000949645458 1733 3073 1139 3053 2721 2102 1703 2124 2879 2481 1855 1995 M14075 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/23 Gene Ontology BP GO:0051590 2.25933005061988e-07 4.3137721483522e-07 3690 2191.09090909091 2125 2.05393662058721e-08 941 1.73745470550291 -1.91480650012417 -1 11.8222822329975 3688 941 2125 1521 2394 2964 2610 3155 1135 1961 1608 1996 M16532 GO_CELLULAR_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_DEFENSE_RESPONSE.html A defense response that is mediated by cells. 52/121 Gene Ontology BP GO:0006968 7.94031525391122e-07 1.1560164854959e-06 1750 2207.45454545455 2125 7.21847101796218e-08 421 1.68760098491621 -1.69517238989038 -1 10.7000978250598 421 1747 2590 3880 3162 1679 2125 485 4207 2236 1750 1997 M10771 GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels. 35/41 Gene Ontology BP GO:0043537 9.52393921655416e-08 2.52860133857159e-07 2245 2230.36363636364 2127 8.65812693531958e-09 1141 2.15206035858217 2.43466924438397 1 15.2091829562283 2244 2340 1645 1792 1685 1883 2127 4064 1141 2935 2678 1998 M11579 GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of activated T cell proliferation. 28/43 Gene Ontology BP GO:0046006 2.20274905298926e-07 4.22317953178117e-07 3580 2311.72727272727 2130 2.00249933958132e-08 928 2.41641179740173 -2.55220861490403 -1 16.510390935384 3577 1863 1447 1309 2385 2208 2130 3894 928 1375 4313 1999 M15441 GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. 67/82 Gene Ontology BP GO:0051785 3.25770926669786e-07 5.64548276273562e-07 2000 2181.27272727273 2130 2.96155431735639e-08 918 2.12624907053383 2.25761833737171 1 14.2249671326564 1645 2674 2130 1999 2643 1602 918 3663 1999 2476 2245 2000 M13979 GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 173/208 Gene Ontology BP GO:0090090 1.58253306599557e-07 3.37466835750567e-07 1495 1922.81818181818 2131 1.4386665271204e-08 819 1.96103716227172 2.37368300360758 1 13.5838384056907 1494 2180 2286 1069 2131 2090 2371 1344 819 3172 2195 2001 M14475 GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 11/15 Gene Ontology BP GO:0009312 1.53600721851169e-06 2.03156383960628e-06 1395 2164.72727272727 2131 1.39637117357281e-07 1060 2.31964957406324 2.28627966272485 1 14.1369006107066 1647 1060 1392 2479 3486 2131 1395 4089 2210 1789 2134 2002 M16390 GO_EPITHELIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. 17/23 Gene Ontology BP GO:0072148 4.59629101964371e-06 5.48232302343045e-06 3970 2504.81818181818 2131 4.17845511122689e-07 368 2.43863714728889 2.77268648710072 1 13.7331792080074 3970 1980 1567 1417 3875 3421 3566 996 368 2131 4262 2003 M11150 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. 94/110 Gene Ontology BP GO:0048010 3.90250864277634e-08 1.97691467186943e-07 3255 2354 2133 3.54773519272879e-09 121 1.85608208347557 1.98390177458211 1 13.3159919102576 3255 121 2105 2133 711 3668 2995 1989 1887 2729 4301 2004 M16132 GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION_INVOLVED_IN_INFLAMMATORY_RESPONSE.html The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. 13/22 Gene Ontology BP GO:0002523 1.58405427351512e-07 3.37501860515352e-07 3820 2491.27272727273 2133 1.44004944324632e-08 962 2.91450441580033 -3.50634992365141 -1 20.243223687752 3817 1004 1242 1488 2133 3171 3295 2077 3933 962 4282 2005 M10204 GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REPRODUCTIVE_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. 46/70 Gene Ontology BP GO:2000242 1.68521811381094e-07 3.53043772249087e-07 1690 2477.72727272727 2134 1.53201658445459e-08 1153 2.24165842718907 2.28203515201235 1 15.4964364338042 1686 3385 1630 3616 2176 1635 1153 3838 3932 2134 2070 2006 M12953 GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_NUCLEATION.html Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. 16/19 Gene Ontology BP GO:0051127 2.32566457628793e-07 4.39533601684311e-07 2825 2207.09090909091 2134 2.1142407473988e-08 593 1.4271886066716 -1.40571248645894 -1 9.67839102173788 2821 898 2808 2134 2417 1655 593 4593 994 3255 2110 2007 M14969 GO_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of MAP kinase activity. 371/484 Gene Ontology BP GO:0043405 6.07185185188453e-08 2.10655912920796e-07 3685 2572.63636363636 2134 5.51986547223958e-09 982 2.01778577628777 2.20866136390914 1 14.4258750936483 3681 2134 982 1064 1228 3601 3522 4362 2111 1026 4588 2008 M16535 GO_CORTICAL_CYTOSKELETON_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CORTICAL_CYTOSKELETON_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. 57/61 Gene Ontology BP GO:0030865 1.58441537713141e-07 3.37501860515352e-07 4525 2825 2134 1.4403777193084e-08 963 2.21535464079546 -2.22258658203528 -1 15.3600204137802 4227 1726 1732 963 2134 4524 3929 4322 1645 1348 4525 2009 M13110 GO_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERFERON_GAMMA_PRODUCTION.html The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. 12/36 Gene Ontology BP GO:0032609 1.15465132926613e-06 1.58999486092787e-06 1710 1969.36363636364 2135 1.0496835775232e-07 276 1.76862030577221 -1.78307025745992 -1 10.9549923552078 1709 1046 2209 2135 3345 1768 3067 276 2913 2555 640 2010 M16710 GO_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 154/182 Gene Ontology BP GO:0042542 1.16255468455642e-07 2.81414964430197e-07 2135 2108.90909090909 2135 1.05686795089978e-08 1470 2.07587013789911 2.31092672590484 1 14.5626206717274 2135 2624 1854 2205 1862 1712 1470 2388 2102 2635 2211 2011 M10182 GO_CYTOKINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 10/19 Gene Ontology BP GO:0042107 1.28454587298466e-06 1.74154777010421e-06 1865 1959.81818181818 2136 1.16776965728335e-07 122 2.25241392861079 3.25053622530505 1 13.8864743605942 1865 2939 2136 2539 3776 2180 1995 122 634 2674 698 2012 M11704 GO_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DIFFERENTIATION.html The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 94/108 Gene Ontology BP GO:0045446 1.29367256074388e-06 1.75187963479083e-06 1835 2471.54545454545 2137 1.17606665587877e-07 1545 2.39184190844617 2.65203000514946 1 14.7464388201465 1831 3891 1545 3033 3400 1716 1884 1872 2544 2137 3334 2013 M14397 GO_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 254/323 Gene Ontology BP GO:0006732 2.20348720838246e-08 1.97691467186943e-07 895 2394 2137 2.00317020950205e-09 171 1.65236722440421 -1.63847544286947 -1 11.8420780580645 895 3861 3683 4380 171 1533 1890 1192 3137 3455 2137 2014 M14617 GO_IRON_ION_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_IMPORT.html The directed movement of iron ions into a cell or organelle. 12/16 Gene Ontology BP GO:0097286 2.94883862945594e-05 3.22390651852878e-05 890 2263.72727272727 2137 2.68079832352376e-06 448 2.45439088239096 -2.66803907152557 -1 11.7845500126697 889 3813 2137 4489 4514 1450 1187 448 2688 2561 725 2015 M11527 GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that activates or increases the frequency, rate or extent of thymocyte aggregation. 8/16 Gene Ontology BP GO:2000400 2.18066094063622e-07 4.19624379491385e-07 1640 2464.90909090909 2139 2.18066115462395e-08 618 2.70609507336424 3.40843483927934 1 18.5113566841738 1640 3274 4308 3397 2449 1535 618 2134 3594 2139 2026 2016 M11532 GO_REGULATION_OF_WATER_LOSS_VIA_SKIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WATER_LOSS_VIA_SKIN.html A process that modulates the rate or extent of water loss from an organism via the skin. 28/34 Gene Ontology BP GO:0033561 4.95202066868767e-10 9.80500092400158e-09 3190 2067.72727272727 2139 4.50183697254756e-11 173 3.6853284804122 -3.50600886675076 -1 31.7394978998537 3186 606 173 1290 2139 3473 3651 3686 2978 298 1265 2017 M14757 GO_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSYLATION.html The covalent attachment of a fucosyl group to an acceptor molecule. 24/29 Gene Ontology BP GO:0036065 1.57096514883272e-07 3.35923751724203e-07 2140 2299.90909090909 2139 1.42815023728313e-08 1142 2.28264346058144 2.20297682688323 1 15.8350127291451 2139 2803 2077 3315 2123 2127 1238 2305 3147 2883 1142 2018 M14040 GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROAUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. 26/27 Gene Ontology BP GO:0016242 4.12851259368703e-07 6.79998906138965e-07 2115 2287.63636363636 2140 3.75319397131139e-08 827 1.54398613803251 -1.10268983408266 -1 10.1639076403072 2113 1888 3095 2426 2788 2140 3274 827 2008 3419 1186 2019 M14527 GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOMERULAR_EPITHELIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells in the metanephros. 18/26 Gene Ontology BP GO:0072010 1.60701766893461e-07 3.4172620756614e-07 3195 2141.63636363636 2140 1.46092526029205e-08 65 2.94124277460564 2.57304377986673 1 20.4128295991039 3192 838 760 65 2140 3244 4605 4343 393 892 3086 2020 M10482 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. 18/23 Gene Ontology BP GO:0045603 2.94586446638716e-05 3.22216910251515e-05 1955 2228.45454545455 2141 2.67809446646825e-06 586 2.8499227507895 -2.93266716567582 -1 13.7026088563578 1955 2858 1499 2141 4233 2444 2090 586 3307 2755 645 2021 M12354 GO_REGULATION_OF_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMOPOIESIS.html Any process that modulates the frequency, rate or extent of hemopoiesis. 319/511 Gene Ontology BP GO:1903706 7.56074136700344e-08 2.29330738099751e-07 1810 2299 2141 6.87340147894864e-09 969 1.95192230492472 -1.98179804833673 -1 13.8735931414085 1810 2603 1415 3513 1440 2318 3634 2141 3456 969 1990 2022 M12943 GO_PLATELET_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_MORPHOGENESIS.html Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. 23/38 Gene Ontology BP GO:0036344 1.6076481159731e-07 3.4172620756614e-07 4010 2414.63636363636 2141 1.46149839404714e-08 255 2.33002278789119 -2.070172099741 -1 16.1473343778071 4009 783 1979 631 2141 3443 3876 4350 255 1937 3157 2023 M15876 GO_PLATELET_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DEGRANULATION.html The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. 113/171 Gene Ontology BP GO:0002576 7.36577945382689e-08 2.26644588482065e-07 1285 2195.18181818182 2141 6.69616336403566e-09 610 2.72866217764622 2.62200435339739 1 19.4544675109458 1281 3025 610 2233 1418 2141 1503 4096 2985 1691 3164 2024 M11888 GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_SYMBIONT_OF_HOST_CELLULAR_PROCESS.html Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. 34/50 Gene Ontology BP GO:0044068 4.25165710809221e-06 5.10396298347603e-06 2145 2703.18181818182 2142 3.86515029522312e-07 1008 1.61217763961527 1.95596421915003 1 9.09468208829588 2142 4184 3395 3765 3851 2047 1008 1867 1673 3795 2008 2025 M15036 GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. 8/16 Gene Ontology BP GO:0033089 2.18066094063622e-07 4.19624379491385e-07 2145 2487.18181818182 2143 2.18066115462395e-08 619 2.70609507336424 3.40843483927934 1 18.5113566841738 1641 3275 4532 3398 2450 1536 619 2143 3595 2143 2027 2026 M10479 GO_VENTRICULAR_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_SEPTUM_MORPHOGENESIS.html The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. 38/43 Gene Ontology BP GO:0060412 2.61804375369094e-07 4.76035857206876e-07 2915 2143.36363636364 2144 2.38004005931218e-08 845 2.41484614089225 2.73421106027609 1 16.3640985666755 2912 1785 1289 845 2518 2144 2662 3968 1031 1241 3182 2027 M11151 GO_POSITIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. 468/658 Gene Ontology BP GO:0043410 1.27153418994613e-08 1.91470828020043e-07 2920 2007.45454545455 2144 1.15594017935929e-09 217 2.2380255204054 2.40409267953981 1 16.1129596083698 2919 2121 217 762 1155 2285 2679 3551 2144 221 4028 2028 M11255 GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 90/124 Gene Ontology BP GO:0051341 9.08475786754397e-08 2.48508985053981e-07 2615 2165.36363636364 2144 8.25887112972108e-09 1633 2.23702357742381 -2.1404568547057 -1 15.8323050979431 2614 2235 1830 1806 1633 2601 2853 1959 1923 2221 2144 2029 M16273 GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_SIGNALING.html Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. 78/95 Gene Ontology BP GO:0014068 9.48115370135832e-08 2.5233974567739e-07 2560 1887.63636363636 2144 8.61923100905415e-09 193 2.85707109971758 3.35582428555522 1 20.2314907220829 2559 193 593 662 1682 2540 2144 3322 2446 1172 3451 2030 M15526 GO_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_DEVELOPMENT.html The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 151/190 Gene Ontology BP GO:0001890 1.68877850788847e-08 1.97691467186943e-07 3640 2255.72727272727 2146 1.53525320077453e-09 63 2.31134646956349 -2.5949991834606 -1 16.6099120892964 3638 2628 1137 801 63 4091 4366 2646 1197 2146 2100 2031 M12221 GO_CELLULAR_EXTRAVASATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_EXTRAVASATION.html The migration of a leukocyte from the blood vessels into the surrounding tissue. 29/37 Gene Ontology BP GO:0045123 6.56295925781444e-07 9.87158427090118e-07 830 2075.90909090909 2147 5.96632837786653e-08 827 2.62750104242487 2.8014987115629 1 16.9169104383885 827 1860 953 2719 3058 1508 1360 2635 3558 2147 2210 2032 M16787 GO_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS.html A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). 92/155 Gene Ontology BP GO:0003014 2.36762939371327e-08 1.97691467186943e-07 3860 1890.36363636364 2149 2.15239038108507e-09 95 2.38866297738326 -2.51158614050534 -1 17.1693110079528 3859 95 505 132 212 4075 4026 2149 2623 499 2619 2033 M11049 GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. 147/173 Gene Ontology BP GO:0045931 1.62246905461998e-07 3.43620778841455e-07 525 2022.09090909091 2150 1.47497197661345e-08 525 1.72315000873578 1.85071325579592 1 11.9077115012631 525 3012 3151 2904 2150 1054 674 2589 2142 2529 1513 2034 M10708 GO_EMBRYONIC_DIGIT_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_DIGIT_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. 74/89 Gene Ontology BP GO:0042733 1.19143049894636e-07 2.8473169551091e-07 4260 2591.90909090909 2151 1.08311869406309e-08 229 2.18432708508878 2.4827207631577 1 15.3173796760361 4259 229 1892 1050 1887 4632 4614 2623 781 2151 4393 2035 M10717 GO_NEGATIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. 32/49 Gene Ontology BP GO:0014014 1.63065566348482e-07 3.44726978745791e-07 4270 2483.09090909091 2154 1.48241434940926e-08 479 2.60762415905727 -1.84387712125426 -1 18.0739338014374 4270 622 1441 671 2154 4534 4391 3346 479 1903 3503 2036 M13130 GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0033875 9.96338424475818e-08 2.57738316115422e-07 2155 2397.36363636364 2154 9.05762245089186e-09 1271 1.68875306312752 -1.77046756391336 -1 11.8953940821926 2154 2776 2973 3892 1732 1553 1271 2139 3060 2970 1851 2037 M15265 GO_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. 142/251 Gene Ontology BP GO:0034341 4.80395898569507e-07 7.64983612609143e-07 645 2069.27272727273 2155 4.36723639517853e-08 632 1.88857017078877 -1.89358585340396 -1 12.3532693366608 644 2194 1524 3321 2889 1606 2157 1960 3680 632 2155 2038 M12183 GO_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEM_CELL_DIVISION.html The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. 40/47 Gene Ontology BP GO:0017145 2.0262175692394e-07 4.00339292979658e-07 2070 2411.09090909091 2156 1.84201614168698e-08 1152 2.11445851877229 1.86155207487894 1 14.4860984082002 2066 3078 2044 2156 2314 1817 1152 4235 1560 2609 3491 2039 M13803 GO_COENZYME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 123/138 Gene Ontology BP GO:0009108 2.5191598658566e-08 1.97691467186943e-07 775 2457 2158 2.29014535882073e-09 270 1.53441336252373 -1.49300764856109 -1 10.9886605325201 773 3621 3750 4514 270 1633 1791 1945 3276 3296 2158 2040 M16457 GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. 29/43 Gene Ontology BP GO:0007212 3.09444021166287e-07 5.429272362318e-07 1900 2250.90909090909 2158 2.81312786083245e-08 1483 2.08859426341535 2.33058963875151 1 14.009275095476 1897 2768 2158 1580 2612 2266 1733 3211 1902 3150 1483 2041 M16908 GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 17/32 Gene Ontology BP GO:0032225 1.64054396441029e-07 3.4618825697964e-07 4430 2458.09090909091 2158 1.4914037152236e-08 338 2.52671159591786 2.34428509338941 1 17.5045947764483 4429 901 1556 1895 2158 3579 3382 2501 338 2133 4167 2042 M11635 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 30/31 Gene Ontology BP GO:1902230 7.45344088024184e-08 2.28163555366877e-07 2150 2242 2160 6.77585557523548e-09 1020 1.97791305726279 2.2919555587007 1 14.0645627445895 2149 2759 2193 2805 1426 2160 1402 1020 2088 2968 3692 2043 M16053 GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_DEPHOSPHORYLATION.html The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. 84/99 Gene Ontology BP GO:0035335 4.49248256765407e-08 1.97691467186943e-07 4085 2388 2160 4.08407514490205e-09 168 2.0664420954316 -1.80119734513907 -1 14.8379846455097 4082 168 1628 1688 896 3487 4241 2160 3068 1930 2920 2044 M11230 GO_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_VIRUS.html Reactions triggered in response to the presence of a virus that act to protect the cell or organism. 175/318 Gene Ontology BP GO:0051607 7.53270827631665e-07 1.10636652808401e-06 975 2356 2161 6.84791895953254e-08 972 1.95432907277947 -1.99923302865474 -1 12.4493523997654 972 3872 2424 2810 3137 1634 1957 1476 3702 2161 1771 2045 M16073 GO_POSITIVE_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 350/563 Gene Ontology BP GO:0051047 5.35668150732845e-09 8.93356238480262e-08 2440 1756.45454545455 2161 4.86971047306473e-10 171 2.26871429545116 -2.08831700626995 -1 17.1460920384672 2440 1334 207 698 636 2472 3874 2161 2595 171 2733 2046 M13372 GO_PHOSPHATE_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_ION_TRANSPORT.html The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/20 Gene Ontology BP GO:0006817 4.24912281422904e-07 6.93308123521039e-07 2165 2130.18181818182 2162 3.86283966810282e-08 861 2.0502789571364 1.84675398748015 1 13.5152423509288 2162 1049 2123 2754 2813 2029 861 2247 3264 1554 2576 2047 M11026 GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 15/16 Gene Ontology BP GO:0009070 1.16564338146798e-05 1.32967360970103e-05 1135 2278.81818181818 2163 1.0596814159402e-06 886 2.06276459189161 1.4159959784859 1 10.7424234474233 1131 2500 2163 2761 4057 2016 1880 1996 886 2689 2988 2048 M15733 GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 19/29 Gene Ontology BP GO:1902893 5.19905041556337e-07 8.16166720095019e-07 1360 2214.81818181818 2163 4.72641058564167e-08 1172 1.6961806234763 1.80322929914757 1 11.0318265331319 1357 2847 2811 2163 2930 1745 1643 1247 3529 2919 1172 2049 M16599 GO_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 193/278 Gene Ontology BP GO:0030098 9.36194771027448e-08 2.50783780632741e-07 4300 2526.54545454545 2163 8.5108619169688e-09 724 2.26209366320137 -2.14174445426617 -1 16.0013423670474 4297 2163 729 724 1671 3815 3567 3917 1888 793 4228 2050 M10656 GO_SECRETION_BY_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION_BY_CELL.html The controlled release of a substance by a cell. 480/746 Gene Ontology BP GO:0032940 1.01446442687396e-10 2.24776332297359e-09 3400 1714 2164 9.22240388109764e-12 154 2.30359742810355 -2.20062553321123 -1 21.3874437286701 3396 1277 154 389 185 2535 3559 2653 2164 288 2254 2051 M14158 GO_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. 132/157 Gene Ontology BP GO:0045444 2.60211082576652e-08 1.97691467186943e-07 1655 2074.72727272727 2164 2.36555532413065e-09 287 2.11041115513265 2.38294917636962 1 15.156108745326 1654 3340 1704 3314 287 1399 1244 2164 2776 2455 2485 2052 M14506 GO_AMMONIUM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSPORT.html The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. 46/97 Gene Ontology BP GO:0015696 4.90338153742918e-07 7.78152602102932e-07 2165 2186.54545454545 2164 4.457620573e-08 1180 2.50604683272097 -1.98838701368098 -1 16.4091568293804 2164 2703 1765 1938 2898 1990 3040 2770 1186 2418 1180 2053 M16571 GO_COFACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein. 163/181 Gene Ontology BP GO:0051188 2.13230572668453e-08 1.97691467186943e-07 530 2541.45454545455 2164 1.93845977031952e-09 154 1.3815342362151 -1.33543538078003 -1 9.88255240175019 528 4109 4007 4422 154 1598 1641 2014 3487 3832 2164 2054 M10370 GO_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_BINDING.html Any process that modulates the frequency, rate or extent of protein binding. 231/277 Gene Ontology BP GO:0043393 3.17891275822084e-08 1.97691467186943e-07 2185 2228.90909090909 2165 2.88992073104988e-09 470 1.65482932484124 2.01872421098587 1 11.8598918000575 2181 2152 3019 2165 470 2088 1922 2449 3044 3062 1966 2055 M15689 GO_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXOCYTOSIS.html A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. Steps that prepare vesicles for fusion with the membrane (e.g. docking and priming) are included in this process. This is the process in which most molecules are secreted from eukaryotic cells. 318/474 Gene Ontology BP GO:0006887 2.3769699538215e-08 1.97691467186943e-07 3290 1836.27272727273 2165 2.1608817995484e-09 216 2.28087641043671 -2.14962200571268 -1 16.3894557002592 3290 1350 363 882 216 2610 3346 3035 2200 742 2165 2056 M16703 GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 10/13 Gene Ontology BP GO:0007260 7.71915367055087e-07 1.12840785513896e-06 2775 2554 2165 7.01741488997858e-08 1263 2.34262016523709 -1.74305300850367 -1 14.92363254743 2775 2063 1721 1641 3149 3516 4458 2165 1263 2087 3256 2057 M14946 GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 143/207 Gene Ontology BP GO:0051896 3.07975918074341e-08 1.97691467186943e-07 3185 2193.54545454545 2166 2.79978111259697e-09 438 2.16075659336034 2.46061714537521 1 15.5203670971065 3183 1585 1238 1078 438 2685 3544 3930 3009 1273 2166 2058 M16307 GO_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS.html An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. 190/443 Gene Ontology BP GO:0006909 2.89143641696833e-08 1.97691467186943e-07 4425 2563.27272727273 2166 2.62857859542743e-09 385 2.1117018703295 -1.82492044164838 -1 15.1654473032327 4421 1492 1015 1868 385 3262 3912 3858 2166 1183 4634 2059 M10218 GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that modulates the frequency, rate or extent of leukocyte proliferation. 192/335 Gene Ontology BP GO:0070663 7.25691025222171e-08 2.2546006802268e-07 2505 2103.27272727273 2168 6.59719135599803e-09 387 2.15501953572191 -2.1021247497088 -1 15.3460998105998 2503 2168 607 1192 1403 2362 3617 3846 3253 387 1798 2060 M10163 GO_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 97/235 Gene Ontology BP GO:0007586 1.33739475873991e-12 4.2332638179706e-11 2690 2078.36363636364 2169 1.21581341703702e-13 104 3.4973735186977 -3.3442067429474 -1 39.0407631471298 2688 2225 104 1678 949 3963 4334 1777 2169 518 2457 2061 M11111 GO_LYMPH_NODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPH_NODE_DEVELOPMENT.html The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. 11/17 Gene Ontology BP GO:0048535 2.27243648842359e-06 2.88110271951907e-06 2175 2203.63636363636 2173 2.06585348698635e-07 1291 1.74264913074039 -1.56967201427492 -1 10.30693097652 2173 2544 2458 1585 3640 2286 1456 1700 3326 1781 1291 2062 M12005 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION.html Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. 84/100 Gene Ontology BP GO:0010595 1.29122998534702e-07 2.97283182672917e-07 2740 2213.09090909091 2174 1.17384551012022e-08 803 2.1664644757415 2.14961175531058 1 15.147391496436 2740 1668 1014 803 1959 2571 2174 3900 2555 863 4097 2063 M12725 GO_RESPONSE_TO_INSULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INSULIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 242/299 Gene Ontology BP GO:0032868 4.05193331110412e-08 1.97691467186943e-07 2485 2300.90909090909 2174 3.68357580521103e-09 752 1.69713454375778 -1.55833779379773 -1 12.1659777108516 2485 1439 3189 1593 752 2174 3701 2033 2339 3765 1840 2064 M13214 GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_RIGHT_VENTRICLE_MORPHOGENESIS.html The process in which the right cardiac ventricle is generated and organized. 18/27 Gene Ontology BP GO:0003215 1.66280815393715e-06 2.18006377578743e-06 1960 2093.36363636364 2174 1.51164491884117e-07 197 2.96876697991992 3.8707274653084 1 18.0263721699391 1960 2828 1153 1594 3519 2121 2632 197 2526 2323 2174 2065 M14209 GO_NEGATIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_T_CELL_SELECTION.html The process of elimination of immature T cells which react strongly with self-antigens. 10/20 Gene Ontology BP GO:0043383 9.33429542943343e-07 1.32821029459186e-06 1370 2230.63636363636 2174 8.48572671804374e-08 790 1.84627383101437 1.36896048611051 1 11.5966271647617 1369 1094 2174 3081 3239 985 790 3748 3636 1570 2851 2066 M11649 GO_TONGUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TONGUE_DEVELOPMENT.html The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. 15/29 Gene Ontology BP GO:0043586 6.13849024261223e-08 2.11573297028702e-07 590 1856.18181818182 2176 5.58044583080891e-09 15 2.5405143209134 2.97345292435699 1 18.1871739775245 588 3214 2176 2188 4253 863 838 15 3517 2192 574 2067 M13921 GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system. 64/112 Gene Ontology BP GO:0031644 3.85926945453919e-08 1.97691467186943e-07 2405 1627.45454545455 2176 3.50842683839911e-09 214 3.19788501054525 3.68781756443093 1 23.0241787854651 2402 2677 393 1892 691 2176 2322 214 2221 423 2491 2068 M16371 GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 1557/2142 Gene Ontology BP GO:0051174 3.79654815664251e-08 1.97691467186943e-07 2180 2106.72727272727 2176 3.7965482215045e-09 331 2.02707458851395 2.22389714233262 1 14.5531536123846 2176 1146 4619 1832 778 1521 2387 2794 2617 331 2973 2069 M10193 GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. 70/79 Gene Ontology BP GO:0061097 1.68551246842954e-07 3.53043772249087e-07 2735 2130.63636363636 2177 1.53228417960341e-08 228 1.974796093988 -1.72008483497518 -1 13.6381708552183 2732 228 1582 1906 2177 2733 2560 4023 1091 1632 2773 2070 M10983 GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_SPINDLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint. 15/17 Gene Ontology BP GO:1903504 5.14941114336089e-05 5.53225815055604e-05 865 2021.63636363636 2177 4.68139243323747e-06 231 2.06105843335696 2.07618568124245 1 9.35621620689076 864 3789 2927 2916 4314 778 231 1283 2177 2688 271 2071 M15820 GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_MEDIATED_SIGNAL_TRANSDUCTION.html Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. 12/29 Gene Ontology BP GO:0007263 2.47546743860822e-06 3.10970572134018e-06 1760 2353.45454545455 2177 2.25042747639949e-07 1110 3.07120599257561 3.346097767488 1 18.1410165691052 1758 2532 1110 3071 3674 1800 2177 3294 3859 1118 1495 2072 M16861 GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION.html A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. 22/22 Gene Ontology BP GO:0042772 7.00979701885821e-07 1.04473368125392e-06 1245 1952.27272727273 2177 6.37254477488252e-08 64 2.1879715091453 2.36857485101523 1 14.0099902579601 1243 2419 2026 2177 3087 670 64 1759 2799 2590 2641 2073 M15165 GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE_SPINDLE_ASSEMBLY_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. 15/17 Gene Ontology BP GO:0090266 5.14941114336089e-05 5.53225815055604e-05 865 2021.54545454545 2178 4.68139243323747e-06 232 2.06105843335696 2.07618568124245 1 9.35621620689076 865 3790 2928 2917 4315 779 232 1262 2178 2699 272 2074 M10422 GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. 30/70 Gene Ontology BP GO:0002820 2.88051655512812e-07 5.13723400958649e-07 1650 2208.54545454545 2179 2.61865175661966e-08 449 2.01347957016076 -2.53277204909473 -1 13.5535537103683 1648 1873 1918 3378 2567 2179 2552 449 4217 2288 1225 2075 M11953 GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. 19/21 Gene Ontology BP GO:0051560 1.2765644751964e-08 1.9160820977706e-07 3025 1851.90909090909 2179 1.16051316600341e-09 19 1.81934119290572 -1.82493086280482 -1 13.0768169682781 3022 837 2518 2291 19 2378 1551 2179 503 3279 1794 2076 M11626 GO_REGULATION_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. 753/1387 Gene Ontology BP GO:0050776 9.94307200814812e-08 2.57738316115422e-07 2040 2499.45454545455 2181 9.94307245303919e-09 1025 2.06310411248754 -1.96861238437221 -1 14.5573531282624 2039 2109 4317 2530 1816 2057 3116 3390 2914 1025 2181 2077 M11083 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. 15/46 Gene Ontology BP GO:0002719 2.64441238367862e-05 2.90473343278013e-05 1355 2096.18181818182 2182 2.40404015472657e-06 771 2.07659657495047 -2.64013252376256 -1 10.0546636521745 1352 2503 2182 1981 4215 1923 2701 771 2277 2189 964 2078 M14053 GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell. 36/77 Gene Ontology BP GO:0050710 1.9433709492741e-07 3.90267804357892e-07 3940 2207.09090909091 2182 1.76670101903807e-08 465 2.44527165207211 2.13437282804867 1 16.7993867320345 3939 1811 1069 1880 2278 2857 2261 465 2182 886 4650 2079 M14382 GO_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE.html Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. 168/350 Gene Ontology BP GO:0051321 5.40091750840288e-07 8.40765110960141e-07 65 1710.18181818182 2182 4.90992621300757e-08 65 1.63894251774152 1.66677870860304 1 10.6329277729896 65 2182 3334 3080 2953 86 131 814 2512 2829 826 2080 M12232 GO_FATTY_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. 50/61 Gene Ontology BP GO:0035337 2.88432957885256e-08 1.97691467186943e-07 1015 2217.81818181818 2184 2.62211783333437e-09 381 1.74559709563736 -1.51867819850705 -1 12.5166130393375 1012 3377 3039 4364 381 1464 1119 1011 3161 3284 2184 2081 M12569 GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. 46/63 Gene Ontology BP GO:0061005 1.73149566496442e-07 3.60278591263368e-07 2315 1550.18181818182 2184 1.57408709203697e-08 348 3.33639917703578 3.61868153983594 1 23.0878172092043 2312 387 407 432 2191 2184 2786 2642 348 851 2512 2082 M13280 GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 586/759 Gene Ontology BP GO:0010563 3.54757877346416e-08 1.97691467186943e-07 2185 2036.81818181818 2184 3.54757883009808e-09 709 2.00292118092752 2.3025322630043 1 14.3783993397626 2184 1243 4417 2274 709 899 2649 2673 2494 1398 1465 2083 M14644 GO_PEPTIDYL_TYROSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_MODIFICATION.html The modification of peptidyl-tyrosine. 167/243 Gene Ontology BP GO:0018212 1.20064615577201e-07 2.8517644526836e-07 2470 2294.36363636364 2184 1.09149656481552e-08 784 2.40953257587768 2.72625226167426 1 16.9065088809393 2470 2184 784 2002 1901 2763 2346 3276 1788 2006 3718 2084 M10056 GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 541/699 Gene Ontology BP GO:0033674 4.06308300510387e-08 1.97691467186943e-07 2745 2119.63636363636 2185 4.06308307939277e-09 257 2.12605676456996 2.32925451530435 1 15.2693075594959 2743 1261 4221 257 878 1774 2185 3107 2255 938 3697 2085 M14584 GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. 387/605 Gene Ontology BP GO:0051346 2.34708540777779e-09 4.15246707315211e-08 2200 1847.90909090909 2185 2.13371400934708e-10 195 2.38894029697183 2.64023105420158 1 18.9185297582169 2198 1325 195 2054 510 2292 2867 2185 2768 573 3360 2086 M14689 GO_DENDRITIC_SPINE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_SPINE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. 33/39 Gene Ontology BP GO:0097061 3.51227487573171e-08 1.97691467186943e-07 595 2147.45454545455 2187 3.19297721073161e-09 306 1.89519603775936 2.63913959791175 1 13.5989884442156 3137 594 2187 306 592 3315 3035 3998 1433 2996 2029 2087 M14544 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. 151/288 Gene Ontology BP GO:0002703 3.15054886744445e-07 5.50695111954134e-07 1395 2125.09090909091 2188 2.86413574420406e-08 989 1.74800150429277 -1.64411796975353 -1 11.6946623492965 1392 2188 2250 2398 2622 1366 2993 1779 4075 989 1324 2088 M13131 GO_ESTABLISHMENT_OF_TISSUE_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_TISSUE_POLARITY.html Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 23/29 Gene Ontology BP GO:0007164 4.10323831373574e-07 6.76794323779242e-07 2765 2340.27272727273 2189 3.73021734457666e-08 1345 2.00823303783842 2.47968305695005 1 13.2584515695683 2764 1916 1913 2189 2784 2530 1974 3153 3565 1610 1345 2089 M14085 GO_RESPONSE_TO_AMINO_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMINO_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. 146/177 Gene Ontology BP GO:0043200 4.77769041546536e-08 1.98310379153973e-07 4450 2632.18181818182 2189 4.343355017474e-09 473 2.61550950076002 -2.36209717277574 -1 18.8067547082378 4447 2189 473 993 974 4649 4332 4632 524 1199 4542 2090 M16753 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. 12/16 Gene Ontology BP GO:2000727 3.13081022042227e-06 3.84269584690711e-06 805 2299.27272727273 2189 2.84619515988478e-07 368 2.87283834085461 3.26699807393723 1 16.6770086171599 802 4296 2189 3758 3762 968 551 368 3880 3504 1214 2091 M10944 GO_PEPTIDE_CROSS_LINKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CROSS_LINKING.html The formation of a covalent cross-link between or within protein chains. 47/103 Gene Ontology BP GO:0018149 4.94282228558033e-11 1.20413361752907e-09 1275 1980.18181818182 2190 4.49347480517398e-12 140 3.66900465757117 4.14661757689675 1 35.2048022950533 1271 1737 140 704 2800 2899 3144 3365 2190 474 3058 2092 M11275 GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper cell differentiation. 15/40 Gene Ontology BP GO:0045622 1.59172776285577e-07 3.38651544607585e-07 1230 2413.81818181818 2190 1.4470253436539e-08 1230 2.27503575688915 -2.74351818923969 -1 15.773236265735 1230 2513 2094 3638 2137 2349 3300 2032 3399 2190 1670 2093 M16105 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. 147/216 Gene Ontology BP GO:1903035 3.53553689819306e-10 7.17110625701642e-09 2710 1790 2191 3.2141244534193e-11 169 2.78502709122139 3.05323220787768 1 24.3664766799897 2707 2191 169 1472 371 2873 3511 565 2867 328 2636 2094 M14570 GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS.html The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). 29/48 Gene Ontology BP GO:0006509 3.96271302612213e-08 1.97691467186943e-07 4035 2048.18181818182 2192 3.60246645227257e-09 388 2.27879376656735 -1.45616172384372 -1 16.3743873951673 4032 653 2192 1759 727 2251 1983 3219 388 2850 2476 2095 M15622 GO_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEEDING_BEHAVIOR.html Behavior associated with the intake of food. 58/131 Gene Ontology BP GO:0007631 3.18075635333817e-08 1.97691467186943e-07 3930 2124.36363636364 2194 2.89159672665954e-09 321 2.45543410288442 -1.79301368350719 -1 17.6524121781439 3926 321 911 2269 471 4043 4264 2194 1308 1220 2441 2096 M15708 GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_INDUCED_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. 18/27 Gene Ontology BP GO:0039531 0.00188244571736216 0.00192463632671635 640 2132.81818181818 2194 0.000171278034332531 496 2.25014100076038 -2.52164800263459 -1 6.48165245420792 639 3196 2326 1979 4541 1857 1124 2343 496 2766 2194 2097 M11452 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. 18/24 Gene Ontology BP GO:2000725 1.92346515137315e-07 3.87776574928045e-07 715 1936.45454545455 2195 1.74860483594744e-08 331 2.3320835273734 2.85825571087278 1 16.0235318078076 713 3200 2195 3215 2270 755 517 331 3724 3155 1226 2098 M15418 GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization. 49/55 Gene Ontology BP GO:2000249 1.54258661861688e-07 3.32005312487041e-07 2965 2330.27272727273 2195 1.40235156979938e-08 1064 2.47415966097233 2.79481719681106 1 17.1866824950282 2195 2695 1064 2566 2108 1999 1384 4027 2962 1670 2963 2099 M11987 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. 28/58 Gene Ontology BP GO:0032715 8.28065329095117e-07 1.19806840058445e-06 1075 2093.09090909091 2196 7.52786946157773e-08 683 2.15353147637736 -1.98020685102666 -1 13.6494523482305 683 3711 2196 3441 3181 1073 1320 780 3191 2375 1073 2100 M11228 GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. 91/151 Gene Ontology BP GO:0051153 6.85507542766482e-08 2.20507296091218e-07 3565 2637.36363636364 2199 6.23188694660462e-09 147 2.07708509169748 -2.03044555288303 -1 14.8086556262401 3562 147 1729 1961 1351 4588 4567 4512 2680 1715 2199 2101 M11855 GO_REGULATION_OF_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENERGY_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of energy homeostasis. 22/44 Gene Ontology BP GO:2000505 6.74316616757112e-05 7.20954783495139e-05 1470 2224.81818181818 2199 6.13033896325158e-06 391 2.14218601870932 2.80618359561747 1 9.4630651721153 1470 3156 2389 2199 4340 1861 391 643 3217 2978 1829 2102 M13213 GO_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE.html Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. 489/1073 Gene Ontology BP GO:0045087 1.75516115940025e-07 3.64262483260007e-07 1400 2045.72727272727 2199 1.59560118129738e-08 464 2.12762089169612 -2.18448719558247 -1 14.6711531376884 1399 2980 485 2725 2199 1888 2626 2423 3256 464 2058 2103 M13259 GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HOMEOSTATIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process. 122/178 Gene Ontology BP GO:0032845 3.14152564660998e-07 5.49737451435736e-07 1765 2335.09090909091 2199 2.85593281382665e-08 1258 1.834328418201 2.08315164271739 1 12.2792975627765 1761 1605 2199 2516 2619 1853 1258 3633 3437 2104 2701 2104 M15176 GO_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. 658/940 Gene Ontology BP GO:0030155 2.65635631048338e-13 9.80954437514219e-12 2760 2092.45454545455 2199 2.65635631048369e-14 60 2.32496589574104 2.52554829307876 1 27.5087970937173 2757 1224 4540 883 394 2353 3310 1904 2199 60 3393 2105 M12565 GO_ORGANELLE_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_FISSION.html The creation of two or more organelles by division of one organelle. 529/735 Gene Ontology BP GO:0048285 2.3445882982273e-07 4.4145377289725e-07 2205 1905.81818181818 2201 2.34458854559658e-08 228 1.59295225813852 1.72411750168277 1 10.8123882604817 228 2978 4375 2762 2505 596 580 1191 2201 2202 1346 2106 M14328 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. 124/154 Gene Ontology BP GO:0048660 1.69275595827706e-07 3.54154382817588e-07 2205 2102.90909090909 2201 1.53886917138505e-08 1196 2.17450860038128 2.26138430494352 1 15.0256450464923 2201 1617 1260 2456 2179 2771 2538 1755 2956 1196 2203 2107 M12359 GO_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ION_TRANSMEMBRANE_TRANSPORT.html A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 537/935 Gene Ontology BP GO:0034220 3.37539811190251e-15 1.80525602467614e-13 3500 2146.90909090909 2202 3.37539811190252e-16 45 2.38853890148559 -2.11748920361976 -1 32.7368229472411 3499 1241 4363 1091 714 2202 2934 2569 1525 45 3433 2108 M14343 GO_CELLULAR_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 74/117 Gene Ontology BP GO:0071398 1.76457317095365e-07 3.65481746361674e-07 2185 2223.18181818182 2202 1.60415755680575e-08 1055 2.3896873836673 2.57810305746117 1 16.4884381127465 2183 1687 1100 2381 2202 2420 2152 2900 3657 1055 2718 2109 M14993 GO_MEIOTIC_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CELL_CYCLE_PROCESS.html A process that is part of the meiotic cell cycle. 135/298 Gene Ontology BP GO:1903046 4.73874129693402e-07 7.5692973754322e-07 40 1639.36363636364 2202 4.30794756149687e-08 39 1.68383064872342 1.71496019052169 1 11.0101460057367 39 2202 3198 2792 2879 76 87 690 2385 2940 745 2110 M10124 GO_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_ACTIVATION.html A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. 409/670 Gene Ontology BP GO:0045321 9.46258144313299e-08 2.52172917840193e-07 4020 2489.63636363636 2203 8.60234713648639e-09 419 2.13837888952251 -1.94322497141856 -1 15.1145010119069 4020 2126 454 718 1680 4217 4397 3999 2203 419 3153 2111 M10216 GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. 77/133 Gene Ontology BP GO:0034763 3.57249049674866e-08 1.97691467186943e-07 1860 2161.27272727273 2203 3.24771868614626e-09 608 1.77862504540721 1.59158013214783 1 12.7555762298344 1859 1684 2782 2918 608 1051 761 4210 3022 2203 2676 2112 M16589 GO_ZYMOGEN_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZYMOGEN_ACTIVATION.html The proteolytic processing of an inactive enzyme to an active form. 132/192 Gene Ontology BP GO:0031638 6.89363669549592e-08 2.20757684405661e-07 2840 2209.09090909091 2204 6.26694264682367e-09 825 2.36159928424388 -1.83315335816019 -1 16.8513458514198 2836 2204 825 1742 1360 3326 3140 3226 2062 1100 2479 2113 M10612 GO_CELLULAR_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 84/108 Gene Ontology BP GO:0034644 4.91526205392456e-07 7.79425154846525e-07 1950 2280.18181818182 2206 4.46842104736152e-08 1137 1.67195194710619 1.8440813419583 1 10.9087261135758 1948 2243 3082 2206 2900 1466 1137 1544 2534 3850 2172 2114 M10173 GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITIC_SPINE_DEVELOPMENT.html Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. 16/20 Gene Ontology BP GO:0061000 2.53330072001822e-06 3.17527003286833e-06 2495 2361.54545454545 2208 2.3030033064723e-07 754 1.96166474858846 1.86464593318541 1 11.5271294154039 2495 1987 2208 1375 3681 2517 1604 3871 754 1499 3986 2115 M12421 GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_CHANNEL_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. 27/47 Gene Ontology BP GO:2001258 5.89367137772171e-08 2.08467047776528e-07 2790 1951.27272727273 2209 5.35788321419068e-09 719 1.92642333439235 1.86958981859399 1 13.7770023835605 2788 719 2564 2397 1200 3226 2826 868 1677 2209 990 2116 M16943 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. 83/143 Gene Ontology BP GO:0002705 2.58929033500767e-07 4.72188114023917e-07 1430 2120.72727272727 2210 2.35390058159481e-08 171 1.73983335404479 -1.62591711425107 -1 11.7649084778066 1429 171 2210 2354 2509 1573 2499 3558 3891 1046 2088 2117 M11346 GO_APOPTOTIC_CELL_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_CELL_CLEARANCE.html The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. 38/46 Gene Ontology BP GO:0043277 2.23834555784782e-08 1.97691467186943e-07 3820 2379.45454545455 2211 2.03485961874673e-09 183 2.03008172920064 -1.60115754235238 -1 14.5749108191677 3820 535 1881 1629 183 4536 4509 2211 2573 1244 3053 2118 M13122 GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 27/35 Gene Ontology BP GO:0040036 1.01915242743968e-07 2.6098603439058e-07 2720 1946.27272727273 2211 9.26502249683665e-09 296 2.22817515149266 2.58542705422552 1 15.7180731537433 2717 734 1858 296 1751 2717 2510 2638 1045 2211 2932 2119 M13511 GO_NEURONAL_ION_CHANNEL_CLUSTERING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_ION_CHANNEL_CLUSTERING.html The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. 16/29 Gene Ontology BP GO:0045161 1.82382458059351e-07 3.7384386667408e-07 2555 1785.90909090909 2211 1.65802248344602e-08 386 2.84254694498585 2.91346682673595 1 19.604385552434 2555 850 791 429 2227 2211 2294 2880 386 1155 3867 2120 M10159 GO_NEURONAL_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURONAL_STEM_CELL_DIVISION.html The self-renewing division of a neuronal stem cell. 16/21 Gene Ontology BP GO:0036445 9.7800306922715e-05 0.000103353356373244 1995 2433.18181818182 2212 8.89133226137752e-06 876 2.04868522024638 2.12747145554805 1 8.69925291118873 1992 3510 2541 2408 4387 1680 1939 2212 876 3252 1968 2121 M13654 GO_RECEPTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECEPTOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 85/123 Gene Ontology BP GO:0043112 2.34243220552672e-08 1.97691467186943e-07 3380 2368 2212 2.12948384587962e-09 157 1.71556794821126 1.86464161329561 1 12.2993467262043 3377 157 2212 1212 202 3512 3970 4176 1323 1844 4063 2122 M11794 GO_COPPER_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COPPER_ION_TRANSPORT.html The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 17/20 Gene Ontology BP GO:0006825 1.78091168767146e-07 3.6715029165863e-07 795 2384.18181818182 2213 1.61901075621566e-08 504 1.45309921509775 -1.46823850351468 -1 9.97870988513381 793 3775 3184 4495 2213 807 504 1391 4028 3383 1653 2123 M15643 GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. 28/31 Gene Ontology BP GO:0046827 2.22643399251712e-07 4.25970286479529e-07 150 1686.18181818182 2214 2.02403110712337e-08 109 1.94459571709104 2.03658968388969 1 13.2567259310185 149 3122 2821 2214 2389 344 109 844 2237 3582 737 2124 M11194 GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. 59/79 Gene Ontology BP GO:0002792 6.87371040662512e-08 2.20574996703632e-07 1875 2355.81818181818 2215 6.24882783762573e-09 1040 2.19829233193972 1.9044616688727 1 15.6790906320842 1871 3365 2215 2389 1356 1160 1040 4104 2159 3309 2946 2125 M10315 GO_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACTIVATION_CASCADE.html A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. 51/269 Gene Ontology BP GO:0072376 2.11408955978607e-08 1.97691467186943e-07 2100 2098 2218 1.921899618274e-09 146 3.04969296517799 -3.27774193320918 -1 21.9519825330792 2096 1743 279 2227 146 3682 3854 3459 2898 476 2218 2126 M10715 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. 88/147 Gene Ontology BP GO:0070664 1.54265094690949e-07 3.32005312487041e-07 2220 2272.81818181818 2218 1.40241005007359e-08 148 1.9531914959141 -2.07535054186374 -1 13.5439771043275 2218 148 1561 2863 2109 2950 3890 2544 3339 1200 2179 2127 M15335 GO_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FERTILIZATION.html The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). 107/221 Gene Ontology BP GO:0009566 1.34259123411152e-07 3.04253649162657e-07 2450 2239.18181818182 2218 1.22053756004152e-08 1299 1.9925011437004 -1.96854662015398 -1 13.9003562887162 2446 2218 2175 1894 1995 2310 2607 1299 2463 3193 2031 2128 M16360 GO_CELLULAR_GLUCURONIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCURONIDATION.html The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. 4/23 Gene Ontology BP GO:0052695 1.48116008215893e-05 1.67318229237327e-05 2850 2034.36363636364 2218 1.48116995450989e-06 3 6.11956229948492 6.84493324439396 1 31.4326491756972 2848 1130 4617 99 4120 2835 1378 622 3 2218 2508 2129 M16343 GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 34/55 Gene Ontology BP GO:0010862 2.97107070025026e-05 3.24592438794657e-05 2425 2598.81818181818 2222 2.7010098408391e-06 1646 2.38208281069474 2.49057982467846 1 11.4264377580618 2423 3945 1872 1747 4237 2148 1814 3698 1646 2835 2222 2130 M12734 GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 26/45 Gene Ontology BP GO:0042036 1.52808462952688e-06 2.02338582276283e-06 1890 2428.81818181818 2223 1.38916880991902e-07 487 2.26472032637253 -2.53153304286122 -1 13.8037425893773 1888 3723 2223 3295 3482 1894 1809 1596 3502 2818 487 2131 M11815 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. 123/161 Gene Ontology BP GO:0097202 8.75997538755122e-08 2.45512816355666e-07 2225 2138.90909090909 2225 7.96361430577871e-09 1293 2.21078698859659 2.84798412344404 1 15.6578608967798 2225 2637 1293 2160 1585 2756 2643 2333 2687 1546 1663 2132 M16638 GO_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. 64/88 Gene Ontology BP GO:0055072 5.7817283816911e-08 2.07580109259326e-07 1880 2662.36363636364 2225 5.25611684876209e-09 1181 1.7074608934694 -1.77653229148424 -1 12.2016285458073 1876 3899 3283 4499 1181 1496 1721 2225 3309 3761 2036 2133 M11301 GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0033865 9.96338424475818e-08 2.57738316115422e-07 2155 2403.36363636364 2226 9.05762245089186e-09 1269 1.68875306312752 -1.77046756391336 -1 11.8953940821926 2152 2774 2971 3890 1730 1551 1269 2226 3058 2967 1849 2134 M11510 GO_NEGATIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling. 11/18 Gene Ontology BP GO:0046851 4.79675515808257e-07 7.6457583191623e-07 3740 2506.54545454545 2226 4.36068745812743e-08 1160 2.71512193597258 -1.83851602869503 -1 17.8099790227804 3739 2056 1482 1385 2886 3840 3756 1160 2226 1782 3260 2135 M14419 GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/49 Gene Ontology BP GO:0032369 6.65548537432701e-07 9.98644741913692e-07 2240 2270.72727272727 2226 6.05044307978093e-08 1782 2.195219051395 2.64545725379102 1 14.1031947361634 2240 2357 1930 2402 3065 2226 2095 2144 1782 2037 2700 2136 M14798 GO_SOMATIC_STEM_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_STEM_CELL_DIVISION.html The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. 32/39 Gene Ontology BP GO:0048103 3.72261909216452e-07 6.28724015820019e-07 2695 2439.72727272727 2226 3.38419974733535e-08 847 2.15880037595924 1.93348932372185 1 14.3355311787328 2691 2351 1819 847 2722 1937 2023 4587 1274 2226 4360 2137 M15310 GO_ENDOPLASMIC_RETICULUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. 44/47 Gene Ontology BP GO:0007029 1.56109665849287e-07 3.35045329887792e-07 2230 2709.27272727273 2228 1.41917888115149e-08 1190 1.51598882553654 -1.18363425167943 -1 10.4804989132245 2228 4446 3862 3545 2115 2099 1190 1467 1905 4161 2784 2138 M15557 GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_CHEMOTAXIS.html Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis. 23/31 Gene Ontology BP GO:2001026 2.73547882170189e-05 3.00192994277805e-05 1580 2633.90909090909 2228 2.48682985020273e-06 1576 2.60634816019192 3.21729155917121 1 12.6083096622212 1576 3154 1828 2197 4220 1775 1639 4459 3156 2741 2228 2139 M13858 GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSPHINGOLIPID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. 57/69 Gene Ontology BP GO:0006687 3.1558091499761e-08 1.97691467186943e-07 2410 2005.72727272727 2229 2.86891745022262e-09 349 1.96945014076829 -1.62142673410417 -1 14.1362303101548 2408 349 2314 3284 461 1697 2708 2107 2029 2229 2477 2140 M11882 GO_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 527/754 Gene Ontology BP GO:0010035 4.36000982745867e-08 1.97691467186943e-07 2230 1954.27272727273 2230 4.36000991300225e-09 168 2.30889889342825 2.55077874049048 1 16.592203433254 2413 1264 4331 168 977 2230 2556 2230 1954 703 2671 2141 M11931 GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. 74/109 Gene Ontology BP GO:0034121 9.03541780465036e-07 1.29279824861741e-06 2235 2290.18181818182 2231 8.2140195595508e-08 929 2.21018445815765 -2.34803943218197 -1 13.9326718003757 2231 1682 1003 1583 3220 3240 4037 2510 2033 929 2724 2142 M13590 GO_SULFUR_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_TRANSPORT.html The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 22/34 Gene Ontology BP GO:0072348 2.17631998288234e-07 4.19487029012077e-07 1380 2139.63636363636 2232 1.97847290742896e-08 598 2.14194703946236 -2.31360649637541 -1 14.6289875729268 1379 1941 2232 3857 2373 1792 2308 598 3320 1450 2286 2143 M14354 GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDOREDUCTION_COENZYME_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed. 104/137 Gene Ontology BP GO:0006733 6.56833925078082e-08 2.17413460714792e-07 1500 2676.90909090909 2233 5.97121767898705e-09 1301 1.47313253943965 -1.62537465304557 -1 10.4796242242999 1500 3028 3740 4157 1301 1871 2233 2082 3722 3704 2108 2144 M16040 GO_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_PHOSPHORYLATION.html The modification of histones by addition of phosphate groups. 37/59 Gene Ontology BP GO:0016572 4.30730303184147e-06 5.16676488970311e-06 765 2060.72727272727 2233 3.91573769543863e-07 197 1.69747239130208 1.920277977374 1 9.57210401324492 761 3089 2975 2644 3855 844 197 1542 2708 2233 1820 2145 M10045 GO_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_RHYTHM.html Any biological process in an organism that recurs with a regularity of approximately 24 hours. 143/192 Gene Ontology BP GO:0007623 1.53563935567604e-07 3.31158121836001e-07 3370 2447.45454545455 2234 1.39603587533311e-08 953 2.11934591391495 2.35574631913842 1 14.7082974062271 3366 2198 1886 1398 2104 3174 2234 3051 953 2931 3627 2146 M11478 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress. 40/48 Gene Ontology BP GO:1902883 4.47750201317012e-08 1.97691467186943e-07 2235 2401.36363636364 2234 4.07045645845228e-09 883 2.0383203292482 2.35407767218365 1 14.634518580664 2234 3402 2596 1654 883 2193 2214 2955 1909 3780 2595 2147 M15700 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress. 40/48 Gene Ontology BP GO:1900408 4.47750201317012e-08 1.97691467186943e-07 2600 2417.45454545455 2235 4.07045645845228e-09 884 2.0383203292482 2.35407767218365 1 14.634518580664 2235 3403 2597 1655 884 2194 2215 3120 1910 3783 2596 2148 M16936 GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 37/58 Gene Ontology BP GO:0002067 1.69649407477398e-06 2.21735587919195e-06 2355 1951 2235 1.54226852999918e-07 431 2.89754763685335 -2.67379484391906 -1 17.5681796655859 2353 2336 1228 810 3530 3066 3821 1059 431 2235 592 2149 M13074 GO_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_B_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. 46/57 Gene Ontology BP GO:0043491 6.26854543280939e-08 2.12948256567067e-07 2325 2267 2236 5.698677828565e-09 1093 1.96433218386986 2.52155323256252 1 14.0307552948067 2325 3389 2886 1271 1254 2627 2091 2236 1093 4020 1745 2150 M15337 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. 30/42 Gene Ontology BP GO:0032743 9.38153968601898e-08 2.5101957538267e-07 4320 2537.54545454545 2236 8.52867280552674e-09 870 2.10727482350481 -2.34861043216588 -1 14.8975336827461 4316 2364 2236 1931 1673 4033 3941 870 1285 1648 3616 2151 M15582 GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. 17/19 Gene Ontology BP GO:0097296 1.65431108704129e-08 1.97691467186943e-07 2085 2183.90909090909 2236 1.5039191813464e-09 52 1.34378795920745 -0.902948891348904 -1 9.60945126026297 2083 1994 3091 3955 52 1700 1502 2381 2428 2601 2236 2152 M11145 GO_LUNG_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_MORPHOGENESIS.html The process in which the anatomical structures of the lung are generated and organized. 50/70 Gene Ontology BP GO:0060425 1.40416083718078e-06 1.88124398946219e-06 2395 2112.09090909091 2238 1.27651066672196e-07 327 2.75057236664496 3.14963071307332 1 16.8832365049484 2391 2699 1263 806 3441 2238 1925 1584 327 2845 3714 2153 M12541 GO_ARACHIDONIC_ACID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONIC_ACID_SECRETION.html The controlled release of arachidonic acid from a cell or a tissue. 8/14 Gene Ontology BP GO:0050482 2.81377275786144e-05 3.08421310773364e-05 1490 2515.36363636364 2238 2.81380838642346e-06 774 2.73700654916493 -2.3629530771909 -1 13.2113546741967 1486 3836 4373 3137 4241 1510 774 2238 1592 3335 1147 2154 M14837 GO_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATPASE_ACTIVITY.html Any process that modulates the rate of ATP hydrolysis by an ATPase. 89/124 Gene Ontology BP GO:0043462 9.63393002460324e-08 2.53938011162528e-07 2850 2383.45454545455 2238 8.75811858770793e-09 1294 2.08258077416912 2.26383869128118 1 14.7103487976627 2847 2238 2033 2569 1700 2828 3982 1987 2993 1747 1294 2155 M15140 GO_CHRONIC_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHRONIC_INFLAMMATORY_RESPONSE.html Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. 15/23 Gene Ontology BP GO:0002544 4.49243281509456e-07 7.25808676688715e-07 2240 2110.09090909091 2238 4.08403066586936e-08 534 3.1564741289838 3.24787561381724 1 20.8004183409876 2238 2006 749 1920 2845 1860 2435 2755 3515 534 2354 2156 M10772 GO_CELL_PROJECTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROJECTION_ASSEMBLY.html Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. 308/403 Gene Ontology BP GO:0030031 2.08295500846722e-08 1.97691467186943e-07 2240 2175.27272727273 2239 1.89359548017144e-09 139 1.73219479342399 1.85146393621549 1 12.4196449586898 2239 1364 2721 3029 139 2228 2727 2876 2027 1797 2781 2157 M11691 GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. 18/19 Gene Ontology BP GO:2000104 4.03789989119503e-06 4.8649270310022e-06 210 1944.81818181818 2239 3.67082482037458e-07 16 1.4848346291652 1.4848346291652 1 8.40075769834158 209 3190 3391 3133 3836 421 16 1316 2239 2758 884 2158 M13439 GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. 93/123 Gene Ontology BP GO:0006767 1.23751970961266e-07 2.89711184326466e-07 3385 2332.63636363636 2239 1.12501798111296e-08 1328 2.0544497348855 -1.9978349684767 -1 14.3832083435673 3384 1656 2038 3026 1925 2842 2966 2239 1328 1366 2889 2159 M15005 GO_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 504/763 Gene Ontology BP GO:0043900 1.68835187309758e-07 3.53391869794108e-07 1185 2386.72727272727 2239 1.68835200137153e-08 1163 1.86428792887355 -1.74027167408579 -1 12.867798652772 1182 2979 4529 3603 2239 1163 1705 2155 3148 2263 1288 2160 M10086 GO_MEIOTIC_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOTIC_CHROMOSOME_SEGREGATION.html The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. 42/69 Gene Ontology BP GO:0045132 9.84603038388712e-07 1.38702934835685e-06 140 1765.18181818182 2240 8.95094071859056e-08 39 1.6051693036102 1.74183700323186 1 10.0348558090446 140 3074 3167 3086 3265 122 39 647 3050 2240 587 2161 M12587 GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of microtubule polymerization. 34/39 Gene Ontology BP GO:0031113 7.73582535916258e-07 1.13013486330246e-06 1400 2503.63636363636 2240 7.03257098118183e-08 631 1.65801143591417 1.66523318626839 1 10.5281009859181 1400 4455 3409 4527 3151 983 1296 2240 1256 4192 631 2162 M14016 GO_REGULATION_OF_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MATURATION.html Any process that modulates the frequency, rate or extent of protein maturation. 81/138 Gene Ontology BP GO:1903317 2.44290147059366e-08 1.97691467186943e-07 4325 2215.45454545455 2240 2.22081954338171e-09 189 2.63611919277499 2.57780910371059 1 18.9597014848173 4321 189 625 2240 245 3498 3591 2352 2032 1526 3751 2163 M15175 GO_LIPOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving liposaccharide. 93/115 Gene Ontology BP GO:1903509 9.22948154360631e-08 2.50183514628907e-07 1255 2311.63636363636 2240 8.3904381189121e-09 1121 1.61620778521384 -1.30511362940564 -1 11.4020709338841 1253 3352 3331 3319 1648 1121 1533 1629 2240 3459 2543 2164 M13057 GO_OVULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVULATION.html The release of a mature ovum/oocyte from an ovary. 24/28 Gene Ontology BP GO:0030728 3.11566439243991e-06 3.82612468145234e-06 2265 2226.72727272727 2242 2.83242618626101e-07 1280 2.7436313297975 3.59509666444603 1 15.9274246229464 2262 1924 1440 3111 3760 2083 1280 1493 2242 2509 2390 2165 M15386 GO_CEREBELLAR_CORTEX_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_CORTEX_FORMATION.html The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. 28/45 Gene Ontology BP GO:0021697 3.1226943315953e-08 1.97691467186943e-07 4565 2413.90909090909 2243 2.83881306901729e-09 455 3.16531946605208 -2.66487344178063 -1 22.7885611807822 4565 2769 1160 621 455 4396 3992 2243 521 1986 3845 2166 M16281 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle phase transition. 81/94 Gene Ontology BP GO:1901989 2.34531211390931e-07 4.4145377289725e-07 475 1884.81818181818 2244 2.1321021490287e-08 473 1.57809218050388 1.82052051094898 1 10.7104683388616 473 2244 3278 2433 2425 827 628 1487 2453 3288 1197 2167 M13553 GO_POSITIVE_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINESIS.html Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. 31/66 Gene Ontology BP GO:0032467 1.3187484585029e-07 3.00938527582835e-07 3735 2761.63636363636 2247 1.19886230686618e-08 1238 1.95160663423192 -1.81483879855949 -1 13.622762709832 3731 1845 2247 1882 1980 4252 4422 4114 1238 1477 3190 2168 M13990 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_EXOGENOUS_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. 76/106 Gene Ontology BP GO:0042590 1.87370296893746e-07 3.80723323571248e-07 390 2472.18181818182 2247 1.70336648047055e-08 387 1.13732693875593 -1.10383282318999 -1 7.76631282260717 387 3645 4046 3579 2247 1063 1058 1429 4406 4127 1207 2169 M15651 GO_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a T cell. 30/50 Gene Ontology BP GO:0002456 1.78302201271802e-07 3.67422560902433e-07 4110 2504.36363636364 2248 1.6209292338415e-08 667 2.34811403423245 2.63020806080156 1 16.1937925959687 4109 667 1369 1756 2214 4407 3712 2427 2990 1649 2248 2170 M10358 GO_DENDRITIC_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. 25/56 Gene Ontology BP GO:0097028 1.497571711693e-06 1.99091462128786e-06 2215 2371.72727272727 2249 1.36142975555693e-07 779 1.92840028425543 -1.54921638615691 -1 11.7516586327021 2214 779 2249 2393 3469 2115 2121 3791 983 3302 2673 2171 M12328 GO_OVARIAN_FOLLICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OVARIAN_FOLLICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. 54/77 Gene Ontology BP GO:0001541 4.31059979362518e-08 1.97691467186943e-07 4200 2221.54545454545 2249 3.91872716189591e-09 353 2.65046200767579 -3.0108584747036 -1 19.0634743448733 4198 2289 1426 1536 822 3994 3624 353 1231 2715 2249 2172 M14746 GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JAK_STAT_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity. 35/50 Gene Ontology BP GO:0046426 3.37394051394219e-07 5.79938870017473e-07 1505 2644.90909090909 2249 3.06721911942997e-08 1504 2.44662894257507 3.1533742404613 1 16.3545604458871 1504 4176 2046 4355 2664 2224 2249 3172 2151 2936 1617 2173 M13834 GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHOBLAST_GIANT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. 12/19 Gene Ontology BP GO:0060707 2.06142906786208e-06 2.63946875419986e-06 2230 2834.18181818182 2250 1.87402818131899e-07 1473 2.31972968042313 2.4587085965309 1 13.8527768127201 2229 4288 2179 4124 3601 2250 1473 1957 3659 2022 3394 2174 M15099 GO_NEGATIVE_REGULATION_OF_STAT_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STAT_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of STAT cascade. 35/50 Gene Ontology BP GO:1904893 3.37394051394219e-07 5.79938870017473e-07 1505 2640.18181818182 2250 3.06721911942997e-08 1505 2.44662894257507 3.1533742404613 1 16.3545604458871 1505 4177 2047 4356 2665 2225 2250 3110 2152 2937 1618 2175 M16862 GO_ACUTE_PHASE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACUTE_PHASE_RESPONSE.html An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. 42/111 Gene Ontology BP GO:0006953 1.48984098307995e-07 3.25493231310707e-07 3775 2250.09090909091 2250 1.35440098542915e-08 296 3.60690472300698 -3.08816130124593 -1 25.1405337075404 3773 463 296 1288 2250 4535 3621 3129 1237 505 3654 2176 M14324 GO_REGULATION_OF_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. 358/578 Gene Ontology BP GO:0022407 4.4230147959545e-08 1.97691467186943e-07 3485 2162 2251 4.02092262261592e-09 196 2.20947895438779 -1.99862276955693 -1 15.8728821917701 3484 2132 324 945 860 2724 3813 4162 2251 196 2891 2177 M15890 GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). 44/109 Gene Ontology BP GO:0007189 1.16096507861548e-07 2.81206169224249e-07 2580 2305.81818181818 2251 1.05542285443721e-08 1010 2.27055593287334 2.34989785692974 1 15.9397750261926 2576 3069 1347 2289 1861 2018 2251 3513 3254 1010 2176 2178 M11753 GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. 26/36 Gene Ontology BP GO:0060122 2.31153595357564e-07 4.37930651139555e-07 2010 2292.90909090909 2252 2.10139654222576e-08 1067 2.49173040148518 2.52259532582009 1 16.9861418697715 2007 1911 2061 3068 2410 2252 2908 3504 1576 2458 1067 2179 M10918 GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_BY_VIRUS_OF_VIRAL_PROTEIN_LEVELS_IN_HOST_CELL.html Any virus-mediated process that modulates the levels of viral proteins in a cell. 15/18 Gene Ontology BP GO:0046719 1.88506323844561e-07 3.82148403692128e-07 800 1951.18181818182 2254 1.71369399996973e-08 37 1.02395653134244 -1.08222334618225 -1 6.9790886198152 797 2514 3553 3449 2254 615 37 1125 2835 3814 470 2180 M15090 GO_REGULATION_OF_CHOLESTEROL_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_STORAGE.html Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 20/23 Gene Ontology BP GO:0010885 1.05032955774965e-07 2.64657043934525e-07 1765 2190.63636363636 2255 9.5484509808614e-09 415 1.76501614537312 -1.54918167828045 -1 12.4157759989595 1764 2848 2704 3687 1776 1040 415 2363 4512 2255 733 2181 M11016 GO_RESPONSE_TO_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ANGIOTENSIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. 21/29 Gene Ontology BP GO:1990776 2.58977878140777e-07 4.72188114023917e-07 2815 2184.54545454545 2258 2.35434462388125e-08 651 2.12433252252501 1.74824813696227 1 14.3899205117694 2811 2427 2028 1656 2510 2258 2012 651 2909 1638 3130 2182 M10486 GO_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical. 783/1214 Gene Ontology BP GO:0048878 7.45909966575473e-10 1.4461329476982e-08 3580 2104 2260 7.45909966825844e-11 112 2.29418813428859 -2.1242454703554 -1 19.2979136084631 3578 1207 4245 677 189 2053 3493 2958 2372 112 2260 2183 M13374 GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. 38/57 Gene Ontology BP GO:2000179 1.84721225117911e-07 3.77428514644205e-07 3540 2626 2261 1.67928400570801e-08 1121 1.95837046638743 2.32221114084019 1 13.4624873397575 3540 1799 2261 2125 2233 4442 4406 1378 1121 2379 3202 2184 M16078 GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of B cell activation. 70/210 Gene Ontology BP GO:0050871 7.6095324016656e-08 2.29469567498056e-07 2825 2548.72727272727 2261 6.91775696806373e-09 1239 2.1043222321123 -1.98597727956748 -1 14.9650328787199 2824 2261 1635 1913 1449 3068 4318 3878 3641 1239 1810 2185 M11065 GO_PRIMITIVE_STREAK_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMITIVE_STREAK_FORMATION.html The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. 10/19 Gene Ontology BP GO:0090009 4.09863577882567e-07 6.76274903506235e-07 2985 2119.54545454545 2262 3.72603322037125e-08 314 2.57530738427079 3.24946185476258 1 17.0351664801067 2982 2561 2081 1263 2783 2615 2262 3081 314 2071 1302 2186 M16434 GO_PROTEIN_O_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. 88/116 Gene Ontology BP GO:0006493 1.83686785895066e-08 1.97691467186943e-07 3205 2146.63636363636 2262 1.66987988571582e-09 89 2.43668252127181 2.43933615133547 1 17.5167410934948 3204 132 654 2690 89 3577 3760 4569 1840 836 2262 2187 M15316 GO_PROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_LOCALIZATION.html A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. 70/79 Gene Ontology BP GO:0031503 7.34245339983068e-08 2.26356255727441e-07 885 1998.72727272727 2263 6.67495785898501e-09 523 1.53793639861721 1.47905912161989 1 10.9165471239714 885 2263 3357 3370 1414 523 1107 2493 3125 2500 949 2188 M11231 GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS.html The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. 51/987 Gene Ontology BP GO:0007606 2.63799765793107e-08 1.97691467186943e-07 3055 2050.18181818182 2264 2.39817971778457e-09 300 2.65559801415315 -2.61298544481743 -1 19.1006342807093 3055 1731 620 1480 300 2264 3084 4414 2536 756 2312 2189 M11933 GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CONDUCTION_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. 12/17 Gene Ontology BP GO:0003161 6.78183225808294e-07 1.01531098767246e-06 4635 2260.36363636364 2265 6.16530395335096e-08 134 2.95524278696886 3.80740912185177 1 19.0022015336309 4631 1018 1519 283 3072 3789 2265 1276 134 3066 3811 2190 M16020 GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLCHOLINE_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. 17/28 Gene Ontology BP GO:0036151 1.66566640382476e-06 2.18319599352017e-06 375 1775.27272727273 2265 1.51424333176115e-07 201 2.22295557609857 -2.27714422437601 -1 13.4678923279955 372 2470 2265 3325 3520 468 201 376 2803 3021 707 2191 M10602 GO_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTRANSMITTER_UPTAKE.html The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. 13/22 Gene Ontology BP GO:0001504 3.56643885318699e-07 6.07195023193526e-07 3380 2188.27272727273 2266 3.24221766485961e-08 793 2.73434595153391 3.03156303160127 1 18.2322524762676 3379 940 884 1118 2697 3195 3448 2266 793 1327 4024 2192 M10667 GO_MEMBRANE_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. 36/45 Gene Ontology BP GO:0044091 1.91342425788242e-07 3.8642200833016e-07 4225 2321.27272727273 2266 1.73947674936389e-08 110 2.43806620120792 2.80795750891357 1 16.7608675457458 4225 449 845 110 2266 4049 3889 4521 116 602 4462 2193 M16705 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. 41/61 Gene Ontology BP GO:0002763 1.50329596557607e-07 3.26708833620993e-07 2065 2553.45454545455 2266 1.3666327893625e-08 1355 2.1075868080159 -2.56424070989533 -1 14.6394235510251 2062 3080 1953 3451 2088 2504 3823 1611 3895 1355 2266 2194 M12060 GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_HYDROXY_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. 78/125 Gene Ontology BP GO:1901616 2.89035236625844e-08 1.97691467186943e-07 2450 1948.54545454545 2267 2.62759309475617e-09 384 2.21373085509599 -2.20845978102935 -1 15.9036454624541 2450 1672 918 2480 384 2019 3134 2342 2598 1170 2267 2195 M15512 GO_TELENCEPHALON_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELENCEPHALON_REGIONALIZATION.html The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. 5/18 Gene Ontology BP GO:0021978 0.000463389587947077 0.000478825616859372 2270 2817.81818181818 2267 4.63486244774733e-05 1603 1.32573099996545 1.34853212997107 1 4.63680702203136 2267 3286 4561 2170 4501 1988 2217 2044 3034 3325 1603 2196 M16142 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_CHEMOTAXIS.html Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis. 65/115 Gene Ontology BP GO:0002690 2.69885871539544e-08 1.97691467186943e-07 2305 1907.63636363636 2267 2.45350795318527e-09 323 2.58681703256665 2.59078449617205 1 18.6029914382092 2301 2267 597 1848 323 1814 2407 3579 2884 455 2509 2197 M12213 GO_RESPONSE_TO_GLUCAGON http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GLUCAGON.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 48/61 Gene Ontology BP GO:0033762 6.4839464538758e-08 2.16270988171212e-07 3810 2456.81818181818 2268 5.8944969499762e-09 1291 2.17119111917239 -2.22799575617166 -1 15.5044530553895 3809 1761 2009 2268 1291 3329 2472 1679 1430 2893 4084 2198 M14708 GO_GLUTATHIONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. 53/71 Gene Ontology BP GO:0006749 6.61847659108825e-08 2.17810395517477e-07 1510 2233 2268 6.01679708199855e-09 1313 1.59386866390274 -1.81344318202021 -1 11.346427974091 1510 2692 2956 3291 1313 1614 1514 1383 3671 2351 2268 2199 M15871 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus. 81/118 Gene Ontology BP GO:1900076 6.57483349282141e-07 9.87817250309914e-07 2825 2285.27272727273 2268 5.97712314341011e-08 1679 2.03922353232366 2.63334860578698 1 13.1033833989834 2823 1679 2403 2176 3061 1854 1889 2523 2268 2530 1932 2200 M13966 GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of T cell proliferation. 66/104 Gene Ontology BP GO:0042130 1.92038898578797e-07 3.87324228472971e-07 1685 1950.27272727273 2269 1.74580832129048e-08 257 1.69580673317385 -1.99130337752741 -1 11.6218029534832 1681 257 2317 2399 2269 1415 2410 2703 3134 1689 1179 2201 M14890 GO_SMOOTHENED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTHENED_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. 67/88 Gene Ontology BP GO:0007224 3.35113144889599e-07 5.76870685597967e-07 760 1957.36363636364 2269 3.04648359941306e-08 538 1.44767253285949 1.57918649364159 1 9.63442967126235 758 2269 3442 2877 2660 538 1052 1115 3039 3114 667 2202 M11070 GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. 36/46 Gene Ontology BP GO:0045747 3.5473839398684e-07 6.04393169981973e-07 1025 2020.27272727273 2270 3.2248950107868e-08 559 3.01063544269635 3.40706305770048 1 20.0924681078536 2624 559 1021 1410 2694 2270 1290 2744 1024 2451 4136 2203 M16839 GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-12 production. 64/124 Gene Ontology BP GO:0032655 9.69171527734515e-07 1.36897077971044e-06 575 2167.54545454545 2270 8.81065413351224e-08 575 1.51319629021951 -1.60283911756159 -1 9.4626929077977 575 2270 2904 2919 3257 919 1572 1430 3947 2421 1629 2204 M16788 GO_LEUKOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. 64/87 Gene Ontology BP GO:0001776 9.93028865335146e-08 2.57738316115422e-07 2865 2249.09090909091 2271 9.02753554689241e-09 1086 1.84568918210887 2.02591453881305 1 13.0113453324741 2865 2271 2581 1086 1727 2379 1768 3853 2129 1721 2360 2205 M10338 GO_REGULATION_OF_GLUCOSE_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT.html Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. 73/89 Gene Ontology BP GO:0046324 1.76239670112824e-07 3.65481746361674e-07 4525 2755.63636363636 2273 1.60217894755636e-08 1947 2.04937284922996 -1.63820446795723 -1 14.1242192766851 4522 2259 2252 2021 2200 3759 2614 3944 1947 2521 2273 2206 M15439 GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 13/19 Gene Ontology BP GO:0050746 2.05766804904374e-08 1.97691467186943e-07 4340 2432 2273 1.87060733480834e-09 132 2.50580622274706 -1.66582212074428 -1 18.0168635763793 4339 1008 1675 2273 132 4201 4127 2561 1705 1755 2976 2207 M11125 GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. 63/118 Gene Ontology BP GO:0045824 1.24081739084818e-06 1.69261897379554e-06 555 2425.63636363636 2275 1.12801644607232e-07 552 1.68546122738596 -1.37823658683146 -1 10.385169371427 552 2275 2437 3911 3376 1306 1847 2358 4337 2067 2216 2208 M12796 GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. 92/121 Gene Ontology BP GO:0009063 1.94244739181824e-07 3.90265690378799e-07 3485 2293 2276 1.76586142120263e-08 126 2.2207670488209 -2.45458289393479 -1 15.2466280382972 3483 126 1581 1695 2276 3112 3627 2166 1165 2781 3211 2209 M15458 GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_6_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. 13/32 Gene Ontology BP GO:0045408 4.12704345891246e-05 4.46376876204549e-05 2255 2636 2276 3.75192807394955e-06 1773 2.2020389506971 -2.0290494666014 -1 10.2254286965301 2253 2925 2107 2404 4284 2273 1923 2937 3841 2276 1773 2210 M16394 GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CGMP_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP. 15/24 Gene Ontology BP GO:0030826 1.0497838542849e-08 1.67857191545966e-07 3490 1897.81818181818 2276 9.54348962994726e-10 3 2.9361964734453 2.88417269596525 1 21.3559542344821 3490 905 667 587 3 2809 2287 2903 2276 535 4414 2211 M11100 GO_HYALURONAN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYALURONAN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. 18/19 Gene Ontology BP GO:0030214 7.68690795659276e-07 1.12475417364862e-06 2245 2254.09090909091 2277 6.98810058403403e-08 1165 1.76435077408696 2.09711772933524 1 11.2145387101152 2241 1976 2296 1947 3146 2909 2839 1551 2448 1165 2277 2212 M10532 GO_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASODILATION.html Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels. 45/71 Gene Ontology BP GO:0042312 2.77195199278266e-07 4.97731305171957e-07 2280 1953.36363636364 2278 2.5199566745842e-08 539 2.78189079508312 3.10086019758573 1 18.810440328636 2539 2702 539 1861 2547 2279 3649 1382 2278 655 1056 2213 M13707 GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNAPTIC_VESICLE_EXOCYTOSIS.html Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. 33/43 Gene Ontology BP GO:2000300 1.40901713294749e-07 3.13391812600606e-07 2800 2094.45454545455 2279 1.28092474835431e-08 584 1.77180479729121 -1.65088601884178 -1 12.3236023117621 2796 584 2477 2314 2036 2114 2279 2533 1469 2382 2055 2214 M14396 GO_MRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_TRANSCRIPTION.html The cellular synthesis of messenger RNA (mRNA) from a DNA template. 26/33 Gene Ontology BP GO:0009299 1.94572574219862e-07 3.90403703253565e-07 845 2259.36363636364 2280 1.76884174025697e-08 845 2.0611879221411 2.32318443612125 1 14.1425724829404 845 3983 2832 3751 2280 1658 1089 860 2808 3673 1074 2215 M12376 GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_TYROSINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. 46/52 Gene Ontology BP GO:0061098 5.23215129754591e-07 8.20198354761261e-07 3745 2329.72727272727 2281 4.75650231080275e-08 434 2.3640896643059 -1.98224651002556 -1 15.4149295760851 3741 434 995 1545 2935 3996 4064 2281 749 1181 3706 2216 M11590 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 14/23 Gene Ontology BP GO:0010744 3.22025316105534e-07 5.59724989106855e-07 1090 2228.45454545455 2282 2.92750330220042e-08 1086 2.36531808295575 -2.31587536842716 -1 15.8466082093559 1086 3519 1731 2301 2635 2282 3022 1377 2645 1952 1963 2217 M10846 GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. 101/144 Gene Ontology BP GO:0071482 1.95451977741622e-07 3.91661521288445e-07 1800 2257 2283 1.77683631914483e-08 1308 1.79510360440476 2.03474933750712 1 12.2995630954284 1800 2228 2665 2611 2283 1526 1308 1914 2472 3445 2575 2218 M12994 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. 25/26 Gene Ontology BP GO:0032232 1.39882188946755e-07 3.11720222782209e-07 2285 2630.72727272727 2283 1.27165634400781e-08 743 1.85273144539321 1.99070636482075 1 12.8962890575014 3387 743 1810 2281 2032 2758 2154 3094 4049 2283 4347 2219 M10185 GO_ANTEROGRADE_AXONAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_AXONAL_TRANSPORT.html The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. 27/32 Gene Ontology BP GO:0008089 5.85305830471695e-07 8.99117870315218e-07 1280 2063 2284 5.32096351082964e-08 159 1.27935354914626 -0.997342000758047 -1 8.23498030438511 1276 1890 3318 2819 2989 833 159 2284 2346 3242 1537 2220 M14530 GO_STRAND_DISPLACEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRAND_DISPLACEMENT.html The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. 25/27 Gene Ontology BP GO:0000732 2.69695698425024e-05 2.96175143915893e-05 340 1952.54545454545 2284 2.45180913321018e-06 98 1.3366328207821 1.49230400484694 1 6.41935746023309 337 2789 3350 2571 4216 451 98 874 3121 2284 1387 2221 M16159 GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule. 53/67 Gene Ontology BP GO:0035306 2.42699015394231e-08 1.97691467186943e-07 1565 2086 2285 2.20635470974211e-09 240 1.64892223466089 2.11123806935194 1 11.817152934161 1562 2285 3003 2936 240 1432 1853 2624 3788 2872 351 2222 M16953 GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 234/317 Gene Ontology BP GO:0000302 5.60346874223237e-08 2.05622555659363e-07 2745 2116.54545454545 2287 5.09406262268589e-09 1144 2.11348740567303 2.37877906536178 1 15.1394010319873 2744 2150 1279 1787 1144 2778 2709 2287 2459 1643 2302 2223 M10499 GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that activates, maintains or increases the rate of skeletal muscle tissue development. 27/40 Gene Ontology BP GO:0048643 1.73739934208683e-06 2.26382501784654e-06 2965 2238.63636363636 2288 1.57945519469043e-07 907 1.88668700274305 2.43295408127531 1 11.3814132685617 2962 2393 2755 2207 3541 2288 907 1499 1767 2569 1737 2224 M12805 GO_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. 97/169 Gene Ontology BP GO:0030216 3.67970109314626e-08 1.97691467186943e-07 4560 2348.36363636364 2288 3.34518286790238e-09 254 2.92278347934071 -2.62297924569555 -1 21.0337694483638 4557 1634 254 1704 645 3971 2921 2288 3237 519 4102 2225 M13637 GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. 107/218 Gene Ontology BP GO:0002706 4.88589954729483e-07 7.7590752879054e-07 2080 2439.27272727273 2288 4.4417278476243e-08 870 1.71131449818762 -1.56104204434467 -1 11.1718396582031 2080 1623 2288 3371 2897 1802 3164 3384 4161 1192 870 2226 M15060 GO_COCHLEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COCHLEA_MORPHOGENESIS.html The process in which the cochlea is generated and organized. 24/37 Gene Ontology BP GO:0090103 5.82845922100511e-07 8.96082995624267e-07 2270 2349 2288 5.29860069558107e-08 1135 1.95232371909918 2.21450596794156 1 12.6293603257038 2270 1895 1964 2413 2987 2095 2408 2953 3431 1135 2288 2227 M14924 GO_NEUROBLAST_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROBLAST_DIVISION.html The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. 16/21 Gene Ontology BP GO:0055057 9.7800306922715e-05 0.000103353356373244 1995 2441.45454545455 2289 8.89133226137752e-06 877 2.04868522024638 2.12747145554805 1 8.69925291118873 1993 3511 2542 2409 4388 1681 1940 2289 877 3257 1969 2228 M16140 GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 81/144 Gene Ontology BP GO:0002285 7.43454627772046e-07 1.09714379417169e-06 2555 2297.36363636364 2290 6.75868071827911e-08 617 2.15647558457131 -2.21062034768471 -1 13.7572135143673 2554 2242 1806 617 3121 3220 3894 2318 1106 2103 2290 2229 M16914 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. 19/23 Gene Ontology BP GO:2000651 3.2055773042659e-07 5.58409786295704e-07 3420 2176.45454545455 2290 2.91416161031313e-08 234 1.9132288856284 -1.67122119947705 -1 12.7982990343989 3420 849 2290 1386 2630 3064 3195 1798 234 1299 3776 2230 M11149 GO_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that modulates the frequency or rate of macrophage activation. 20/34 Gene Ontology BP GO:0043030 1.11969957119293e-07 2.7397444355352e-07 3515 2560 2292 1.01790875289139e-08 1159 2.19468116231941 -2.68880665400759 -1 15.4301388484685 3513 1964 1483 2292 1833 4538 3733 1601 3209 1159 2835 2231 M13193 GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. 26/30 Gene Ontology BP GO:0036119 3.10812660087194e-07 5.44917598864248e-07 1505 2262.45454545455 2292 2.82557003634857e-08 927 2.14539167597234 2.4417232238537 1 14.3896405135772 1501 3124 2292 1965 2614 2100 2782 927 2677 3133 1772 2232 M16252 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. 118/208 Gene Ontology BP GO:1902106 9.74758682157024e-07 1.37566034215245e-06 915 2420.27272727273 2292 8.86144649132449e-08 915 1.72305947339985 -1.77053971587154 -1 10.7868097792368 915 3343 2671 3553 3260 1660 2292 1417 4038 2005 1469 2233 M12319 GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of neutrophil migration. 23/50 Gene Ontology BP GO:1902624 7.21673977307346e-07 1.07009210210678e-06 2815 2402.90909090909 2293 6.56067467309807e-08 492 2.17105020870244 -2.56881065097556 -1 13.8763609897827 2813 1904 1318 2267 3104 3175 3847 2293 3694 492 1525 2234 M14161 GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. 164/262 Gene Ontology BP GO:0071241 1.98780187506935e-07 3.96452727162352e-07 2870 2113.63636363636 2294 1.80709277697862e-08 721 2.30331090251428 2.30981784509301 1 15.8005541823154 2867 1543 721 1932 2294 2400 2199 2594 2820 791 3089 2235 M12374 GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_DIFFERENTIATION_IN_THYMUS.html Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus. 27/37 Gene Ontology BP GO:0033081 2.12499318648759e-07 4.13188186240148e-07 3625 2403 2295 1.93181217431089e-08 1501 2.40989739906525 2.67531676245076 1 16.490261946734 3623 2771 1501 2168 2349 2813 1962 3751 2295 1539 1661 2236 M11621 GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). 48/58 Gene Ontology BP GO:0007223 4.73505024371382e-07 7.56859800206128e-07 1125 1977.81818181818 2296 4.30459205712443e-08 653 1.51744790529327 1.76738852611585 1 9.91110131056703 1122 2296 3199 2639 2877 715 1164 1345 3376 2370 653 2237 M12392 GO_REGULATION_OF_THYMOCYTE_AGGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_AGGREGATION.html Any process that modulates the frequency, rate or extent of thymocyte aggregation. 27/37 Gene Ontology BP GO:2000398 2.12499318648759e-07 4.13188186240148e-07 3625 2404 2296 1.93181217431089e-08 1502 2.40989739906525 2.67531676245076 1 16.490261946734 3624 2772 1502 2169 2350 2814 1963 3752 2296 1540 1662 2238 M16415 GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 42/54 Gene Ontology BP GO:0044246 9.6310451264199e-07 1.36414110036222e-06 1275 2548 2296 8.75549940241012e-08 1275 2.14689206094883 2.2302496514395 1 13.4763951899989 1275 3934 2238 3651 3251 1959 1603 2099 3195 2527 2296 2239 M12551 GO_VESICLE_CYTOSKELETAL_TRAFFICKING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_CYTOSKELETAL_TRAFFICKING.html The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. 49/56 Gene Ontology BP GO:0099518 3.69676326494005e-07 6.25399709942984e-07 2735 2032.63636363636 2297 3.36069444193153e-08 410 1.5433217158904 -1.58259202192818 -1 10.2200306532656 2208 410 3113 2297 2717 1806 2696 1146 2734 2731 501 2240 M14417 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity. 50/115 Gene Ontology BP GO:0002707 6.39014410114977e-07 9.63803581933546e-07 960 2194.81818181818 2297 5.80922359748981e-08 407 1.53825441853218 -1.42610539518078 -1 9.87427902859329 956 407 2693 3442 3047 1079 2524 2054 4479 2297 1165 2241 M13603 GO_PARTURITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARTURITION.html The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. 13/26 Gene Ontology BP GO:0007567 2.02029050292656e-07 3.99633168316993e-07 2710 2155.09090909091 2298 1.83662789859333e-08 1235 2.51046636069772 2.16842839485867 1 17.2223963091057 2709 2021 1384 2298 2310 2552 1851 2709 1235 1334 3303 2242 M16572 GO_LYSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. 13/16 Gene Ontology BP GO:0006553 1.85184926331139e-07 3.77757765111262e-07 1535 2252.72727272727 2298 1.6834994719916e-08 602 2.48580544866221 1.43000275479582 1 17.1176940432619 1535 4045 2877 2556 2238 1287 602 2637 776 3929 2298 2243 M11271 GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_GAMMA_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 90/224 Gene Ontology BP GO:0038094 4.66341444412389e-08 1.98163172680443e-07 2300 2232.09090909091 2299 4.2394677663417e-09 137 1.96562071642727 -1.55736584355184 -1 14.1063280777502 3757 137 2297 658 941 2299 2473 3692 607 3170 4522 2244 M15711 GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING.html Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. 16/18 Gene Ontology BP GO:0060055 2.76568911958877e-08 1.97691467186943e-07 1310 1937.09090909091 2300 2.51426286759737e-09 345 1.65265435638167 1.9166393236596 1 11.8441555098563 1307 2479 2359 3062 345 1544 977 948 3582 2405 2300 2245 M10341 GO_PINOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PINOCYTOSIS.html An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. 21/23 Gene Ontology BP GO:0006907 2.28945575482991e-07 4.34632298132336e-07 3935 2475 2301 2.08132363007713e-08 793 1.59362109525026 1.17551006362119 1 10.8286075698154 3933 793 2301 1741 2405 4552 4523 1023 2017 1280 2657 2246 M10782 GO_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HINDLIMB_MORPHOGENESIS.html The process in which the anatomical structures of the hindlimb are generated and organized. 35/54 Gene Ontology BP GO:0035137 1.14984159160989e-06 1.58477871023721e-06 3330 2620.36363636364 2302 1.04531108416463e-07 1104 2.43171287699002 -2.01114529650774 -1 15.108394956114 3330 2732 1647 1972 3342 3848 4499 1104 1985 2302 2063 2247 M13024 GO_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 89/116 Gene Ontology BP GO:0048145 3.6369448126204e-08 1.97691467186943e-07 3155 2362.18181818182 2302 3.30631352067709e-09 630 2.0560496620813 2.20987629931858 1 14.7627935104947 3155 1661 1847 1998 630 2770 3223 2119 2302 2536 3743 2248 M15915 GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity. 44/101 Gene Ontology BP GO:0002715 4.99424042270658e-07 7.89456114756698e-07 2030 2493.45454545455 2302 4.54021959677644e-08 1404 1.84190065216721 -1.32698962888949 -1 12.0180205518498 2030 2302 2020 2839 2909 1491 2622 3588 4082 1404 2141 2249 M10452 GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CALCIUM_MEDIATED_SIGNALING.html Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. 79/108 Gene Ontology BP GO:0050848 1.48635037546446e-08 1.97691467186943e-07 2305 1670 2304 1.35122762318769e-09 33 2.30175296305369 2.48149554818632 1 16.5405013344779 2305 174 763 1491 33 2329 2767 2386 2304 340 3478 2250 M10684 GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 95/190 Gene Ontology BP GO:0032649 1.26841743976286e-06 1.72533854312767e-06 2225 2522.36363636364 2304 1.15310742824892e-07 595 1.73570641103969 -1.74030290929095 -1 10.6825564586015 2222 2233 2304 3473 3386 2576 3758 595 3821 1659 1719 2251 M12620 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 30/44 Gene Ontology BP GO:0034032 9.96338424475818e-08 2.57738316115422e-07 2155 2411.45454545455 2304 9.05762245089186e-09 1270 1.68875306312752 -1.77046756391336 -1 11.8953940821926 2153 2775 2972 3891 1731 1552 1270 2304 3059 2969 1850 2252 M12597 GO_DNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS.html The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 26/30 Gene Ontology BP GO:0006308 1.61160279088256e-07 3.42234379747819e-07 2290 2462.63636363636 2305 1.46509355358183e-08 130 1.49854744505385 -1.92907701872706 -1 10.3437086551287 2286 3977 3463 3893 2143 2305 3236 477 1508 3671 130 2253 M16094 GO_SERTOLI_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. 20/26 Gene Ontology BP GO:0060008 1.4772788359398e-08 1.97691467186943e-07 2310 2144 2306 1.34298076896326e-09 32 2.67248911100189 3.25805707131249 1 19.2228444215777 2306 2437 1809 2815 32 2602 1991 3200 1624 2258 2510 2254 M16762 GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of macrophage differentiation. 13/17 Gene Ontology BP GO:0045651 4.61662417433066e-06 5.50375410790689e-06 3280 2526.09090909091 2306 4.1969398747144e-07 1169 2.04721511281811 -2.55190413740624 -1 11.5069901813795 3280 2916 1940 2110 3877 3645 3977 1229 2306 1338 1169 2255 M11399 GO_MULTICELLULAR_ORGANISMAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_MOVEMENT.html Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. 44/75 Gene Ontology BP GO:0050879 9.52704219995002e-08 2.52860133857159e-07 3710 2729.45454545455 2307 8.6609478295601e-09 435 1.94583163020057 -1.52740992273937 -1 13.7408716984962 3710 2307 2206 2111 1686 3709 4085 2982 435 2181 4612 2256 M12954 GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEGAKARYOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. 14/31 Gene Ontology BP GO:0045652 2.01541358876785e-07 3.99391798489642e-07 2415 2054.45454545455 2307 1.83219433945393e-08 496 2.55941166639188 -3.27315851364856 -1 17.5611025117061 3034 2508 1654 1226 2307 3104 2415 496 1485 1956 2414 2257 M13690 GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CALCIUM_ION_REGULATED_EXOCYTOSIS_OF_NEUROTRANSMITTER.html The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. 21/39 Gene Ontology BP GO:0048791 2.35426304565964e-07 4.41848711172251e-07 2915 1640 2307 2.14023936144907e-08 259 3.07198580658404 -3.03205317026037 -1 20.9552592316725 2913 710 382 421 2429 2307 2481 2617 259 483 3038 2258 M12064 GO_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETION.html The controlled release of a substance by a cell or a tissue. 575/906 Gene Ontology BP GO:0046903 2.17672643670357e-08 1.97691467186943e-07 3160 2062.45454545455 2308 2.17672645802518e-09 214 2.34272683155689 -2.22526341736651 -1 16.8369546842242 3158 1240 4342 390 227 2581 3576 2294 2357 214 2308 2259 M14853 GO_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. 16/21 Gene Ontology BP GO:0030225 1.6859300707876e-07 3.53043772249087e-07 2170 2430.36363636364 2308 1.53266381816891e-08 747 1.9193160747378 2.13331800670929 1 13.251842036028 2169 2486 2576 1439 2178 1788 747 4492 2308 3629 2922 2260 M15233 GO_MUSCULOSKELETAL_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCULOSKELETAL_MOVEMENT.html The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. 44/75 Gene Ontology BP GO:0050881 9.52704219995002e-08 2.52860133857159e-07 3715 2695 2308 8.6609478295601e-09 436 1.94583163020057 -1.52740992273937 -1 13.7408716984962 3711 2308 2207 2112 1687 3710 4086 2593 436 2182 4613 2261 M14038 GO_RESPONSE_TO_NICOTINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NICOTINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. 44/72 Gene Ontology BP GO:0035094 8.12333854410081e-07 1.17934147412484e-06 2960 2091.27272727273 2309 7.38485594871411e-08 478 2.55713738464402 2.75690311334516 1 16.2476544860965 2956 478 1123 1229 3170 3433 2318 2739 2309 1009 2240 2262 M15723 GO_ARACHIDONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARACHIDONATE_TRANSPORT.html The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/14 Gene Ontology BP GO:1903963 2.81377275786144e-05 3.08421310773364e-05 1490 2540.90909090909 2313 2.81380838642346e-06 775 2.73700654916493 -2.3629530771909 -1 13.2113546741967 1487 3837 4569 3138 4242 1511 775 2313 1593 3337 1148 2263 M16202 GO_REGULATION_OF_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 145/242 Gene Ontology BP GO:0044070 4.5615948543495e-08 1.97760774550163e-07 540 2292.18181818182 2313 4.14690449902908e-09 536 2.43276820296722 2.74370181042641 1 17.4880206102004 3737 1570 536 1689 916 3517 3335 3621 2313 538 3442 2264 M13833 GO_POSITIVE_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_DEATH.html Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 721/961 Gene Ontology BP GO:0010942 3.98187508568042e-08 1.97691467186943e-07 2880 2385.18181818182 2314 3.9818751570294e-09 839 1.96926391856646 2.13318733054472 1 14.1348829588417 2878 1222 4452 2105 839 1736 3051 3275 2314 1289 3076 2265 M15300 GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a humoral immune response. 8/19 Gene Ontology BP GO:0002922 3.27934581530785e-05 3.57097965799846e-05 1065 2313.45454545455 2314 3.27939420980336e-06 451 2.69265422497829 -2.96374398414287 -1 12.8104897708958 1063 2578 4547 3074 4266 876 451 2314 3586 1523 1170 2266 M11122 GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 24/27 Gene Ontology BP GO:0010875 2.02059570516085e-07 3.99633168316993e-07 2315 2500.18181818182 2315 1.83690535522092e-08 656 3.04533410400593 4.14049503288808 1 20.9158122795602 3358 770 1427 656 2311 4074 4032 3533 2918 2108 2315 2267 M11535 GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process. 18/36 Gene Ontology BP GO:1902932 9.85329269385707e-07 1.38763229129894e-06 2740 2189.09090909091 2316 8.95754282447492e-08 694 2.99427703205675 -2.84862564699995 -1 18.8162482347783 2739 3177 1873 1777 3266 3142 2436 694 1158 2316 1502 2268 M12902 GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. 14/15 Gene Ontology BP GO:1902895 2.13827358906523e-06 2.72660647024405e-06 2035 2585.18181818182 2316 1.94388697031557e-07 1202 1.48293932199509 1.53689168476139 1 8.79232576845001 2031 2912 2981 2198 3619 2287 2316 1202 4111 2952 1828 2269 M10390 GO_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 49/68 Gene Ontology BP GO:0010043 2.04053786488988e-07 4.02485065084046e-07 3450 2168.81818181818 2318 1.85503459468482e-08 371 2.50929800149476 -2.39893490293491 -1 17.2059651381232 3450 371 942 1115 2318 3232 2620 3980 984 1433 3412 2270 M12321 GO_REGULATION_OF_SPINDLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPINDLE_CHECKPOINT.html Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. 18/20 Gene Ontology BP GO:0090231 1.78884611249815e-05 2.00036072132994e-05 700 2023.72727272727 2318 1.62623696180345e-06 236 1.80047960838283 1.89329074473552 1 9.01747978836395 700 2873 3018 4125 4140 623 236 1261 2715 2318 252 2271 M13060 GO_SUBSTANTIA_NIGRA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBSTANTIA_NIGRA_DEVELOPMENT.html The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). 78/111 Gene Ontology BP GO:0021762 1.31681563455948e-07 3.00792496200552e-07 3885 2587.36363636364 2318 1.19710519397984e-08 1127 2.13322390097159 -1.74368259757483 -1 14.9015124788876 3884 2254 2318 1221 1978 1483 2735 3525 1127 3601 4335 2272 M10366 GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. 11/17 Gene Ontology BP GO:0031953 8.95195397347043e-07 1.28401485322312e-06 3675 2704.36363636364 2319 8.1381432873502e-08 1301 2.23352229202965 2.44609521388946 1 14.0881209821592 3675 2051 1691 2319 3212 3389 3002 2200 2307 1301 4601 2273 M10974 GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. 98/165 Gene Ontology BP GO:0048525 1.603981994967e-05 1.80186581906843e-05 765 2409 2319 1.45817608131091e-06 764 1.9491912788457 -2.09442717924029 -1 9.86710021226674 764 3354 2509 2421 4118 2068 2319 1482 3406 2043 2015 2274 M16446 GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT.html The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. 42/58 Gene Ontology BP GO:0031076 2.16516474193818e-07 4.18632859796095e-07 3750 2316.54545454545 2319 1.96833177729665e-08 477 2.27716805965245 -1.72733099249425 -1 15.5618302656438 3746 477 1416 1914 2364 3368 2865 4435 1370 1208 2319 2275 M12775 GO_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 105/118 Gene Ontology BP GO:0038127 9.60476311357036e-08 2.53925924815016e-07 2075 2544.72727272727 2320 8.73160321172295e-09 1696 1.87722843796095 -1.96024790144832 -1 13.2487285872858 2071 2645 2613 2167 1696 2956 3629 2004 2320 3940 1951 2276 M12872 GO_PROTEIN_O_LINKED_FUCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_FUCOSYLATION.html The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. 18/19 Gene Ontology BP GO:0036066 3.70223575104688e-06 4.48957595768077e-06 2005 2219.63636363636 2321 3.36567452846487e-07 450 2.5581322693296 2.58524924342597 1 14.6511841060736 2004 3183 1669 2751 3810 2376 1518 1620 2714 2321 450 2277 M12904 GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that activates or increases the frequency, rate, or extent of an immune system process. 782/1372 Gene Ontology BP GO:0002684 7.34386489658915e-08 2.26356255727441e-07 2180 2591 2323 7.34386513928473e-09 701 2.12527655051217 -2.05849615594881 -1 15.1287845488866 2178 3295 4393 2323 1508 2028 3205 3599 3207 701 2064 2278 M15971 GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 22/23 Gene Ontology BP GO:0048011 1.82144511439983e-07 3.73685366724092e-07 4205 2537.18181818182 2323 1.65585933200244e-08 618 2.87593833796743 -2.21271285220573 -1 19.8365784091548 4205 3157 2323 842 2225 3462 3979 1711 618 3842 1545 2279 M16529 GO_POST_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. 115/154 Gene Ontology BP GO:0009791 3.2006912134849e-08 1.97691467186943e-07 2655 2269 2325 2.90971932731861e-09 477 2.31138860136283 2.79365562052045 1 16.6102169204853 2651 3026 1236 2325 477 3788 4473 735 1809 2352 2087 2280 M16793 GO_PROGESTERONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROGESTERONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. 14/26 Gene Ontology BP GO:0042448 1.47271893637301e-07 3.23095401168139e-07 2025 2567 2325 1.33883548632675e-08 1413 2.24345043042058 -2.56715105000692 -1 15.6021257557146 2021 2893 1974 3363 2067 2325 2096 3417 4173 2495 1413 2281 M13685 GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that activates or increases the frequency, rate or extent of epidermis development. 38/47 Gene Ontology BP GO:0045684 6.20082577330242e-06 7.28229235819691e-06 3900 2466.18181818182 2326 5.63713022795757e-07 1361 2.53696714584813 -2.02434544407574 -1 13.9538828009152 3896 2724 1361 2326 3937 2983 2902 1800 1417 1762 2020 2282 M15554 GO_RENAL_ABSORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_ABSORPTION.html A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). 18/35 Gene Ontology BP GO:0070293 2.10335826170818e-07 4.10697691637775e-07 1815 2510.90909090909 2326 1.9121440570949e-08 1367 3.07967097251668 -3.46007906553639 -1 21.1134969912383 1812 2856 1529 3354 2340 2210 2239 3552 4035 2326 1367 2283 M14433 GO_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANOIKIS.html Any process that modulates the frequency, rate or extent of anoikis. 48/78 Gene Ontology BP GO:2000209 2.29255466479164e-07 4.34865750316979e-07 2125 2386.54545454545 2327 2.08414082153817e-08 1491 1.99068746484877 2.16607993594723 1 13.5543400207299 2123 2292 2118 3139 2407 2340 2055 2327 1491 2371 3589 2284 M10879 GO_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SECRETION.html The controlled release of proteins from a cell. 114/190 Gene Ontology BP GO:0009306 4.1979292368022e-08 1.97691467186943e-07 3290 2076.72727272727 2329 3.81629937900453e-09 60 1.98649678471237 -1.89242229795888 -1 14.2595658623925 3286 60 1310 1590 786 2644 3492 2857 3543 947 2329 2285 M12762 GO_MYELOID_LEUKOCYTE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_ACTIVATION.html A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. 105/180 Gene Ontology BP GO:0002274 2.49626761132107e-07 4.61127209296305e-07 2330 2475.54545454545 2329 2.26933444960398e-08 1520 1.9387393121225 -1.98898709497022 -1 13.1443974527289 2329 2219 1539 2367 2474 3310 4215 1520 2981 1978 2299 2286 M13485 GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. 355/457 Gene Ontology BP GO:0071902 4.41145772469165e-08 1.97691467186943e-07 3195 2440.09090909091 2331 4.01041619377323e-09 850 2.08002451232043 2.22254790500838 1 14.9362558884125 3191 2601 1253 1805 850 2171 2331 4157 2399 1697 4386 2287 M10851 GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOLIPID_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a sphingolipid. 11/14 Gene Ontology BP GO:0090520 3.52477799452631e-07 6.02084875496729e-07 3340 2384.63636363636 2332 3.20434414477858e-08 782 2.58386964747379 -2.8195815309132 -1 17.2329081499749 3337 1053 1737 1370 2684 3972 3921 782 3619 2332 1424 2288 M12406 GO_COMPLEMENT_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION.html Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. 38/240 Gene Ontology BP GO:0006956 2.03115228822236e-08 1.97691467186943e-07 1755 2285 2332 1.84650209725000e-09 129 2.86415892927996 -3.2326180789319 -1 20.6096102249913 1755 2332 582 3269 129 3434 3855 3823 3677 880 1399 2289 M11514 GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOTIC_SPINDLE_ORIENTATION.html A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. 21/25 Gene Ontology BP GO:0000132 1.5218654400523e-07 3.29206875525957e-07 1780 2073.81818181818 2333 1.38351413211674e-08 665 1.8450121303171 2.39188465456104 1 12.794886954031 1780 2420 2536 3320 2097 2364 2333 665 1696 2443 1158 2290 M12782 GO_PHOSPHOLIPID_SCRAMBLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_SCRAMBLING.html The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). 15/21 Gene Ontology BP GO:0017121 4.54298823744162e-08 1.97760774550163e-07 3320 2338.81818181818 2333 4.12998939204918e-09 909 2.38518610299836 -2.04423356515192 -1 17.1437633278592 3317 955 1477 2333 909 3261 3642 1330 3970 981 3552 2291 M11644 GO_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. 286/425 Gene Ontology BP GO:0002521 9.01175798953802e-08 2.47798486982639e-07 3585 2326.18181818182 2334 8.19250759880228e-09 592 2.25438078372432 2.4748522343113 1 15.9590517794799 3581 2140 592 1326 1624 2980 3042 2849 2334 966 4154 2292 M12115 GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ASSEMBLY_OR_DISASSEMBLY.html The formation or destruction of chromatin structures. 133/208 Gene Ontology BP GO:0006333 8.05676566465287e-07 1.17077234970736e-06 1070 2291.36363636364 2335 7.32433510470535e-08 1067 1.94807781801546 1.70098694741578 1 12.3575054231024 1067 2207 2335 3622 3167 1136 2328 2350 2777 1684 2532 2293 M15020 GO_ASYMMETRIC_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically. 38/51 Gene Ontology BP GO:0008105 1.39340560004144e-07 3.11452674737746e-07 3685 2502.54545454545 2335 1.26673244390459e-08 548 2.31293433943017 2.88980978516356 1 16.1286420678521 3683 2335 1899 1543 2025 3885 3553 916 548 3221 3920 2294 M16578 GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. 23/33 Gene Ontology BP GO:0045940 3.69755985827025e-07 6.25399709942984e-07 2335 2058.90909090909 2335 3.36141861792966e-08 423 2.44221548314566 -2.42928559223225 -1 16.2384677430419 2335 2416 2054 1433 2718 2582 2838 423 1117 2745 1987 2295 M12389 GO_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE.html Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. 894/1049 Gene Ontology BP GO:0000278 2.96704778313613e-07 5.25530008942993e-07 965 2363.81818181818 2337 2.96704817928797e-08 365 1.56716304831628 1.68693676428261 1 10.5074547651598 365 3584 4366 3476 2644 962 964 1728 2337 3679 1897 2296 M13532 GO_TETRAPYRROLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 51/86 Gene Ontology BP GO:0033013 1.00285307213647e-07 2.5839643756244e-07 1615 2283.63636363636 2337 9.11684652591596e-09 263 1.78237896643316 -1.56582167267071 -1 12.5590246050164 1614 2697 3087 2757 1739 2132 2137 2337 263 3867 2490 2297 M10752 GO_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 47/52 Gene Ontology BP GO:0034405 7.56549931190884e-08 2.29330738099751e-07 2980 2586.27272727273 2338 6.87772688370547e-09 1441 2.18578528644773 2.20939336292833 1 15.5493612850656 2160 2305 2338 2980 1441 2473 3156 2321 4060 2238 2977 2298 M12523 GO_L_ASCORBIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ASCORBIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. 11/12 Gene Ontology BP GO:0019852 1.44475494651684e-06 1.92896549961057e-06 4440 2390.54545454545 2338 1.313414450271e-07 432 1.73357293927662 -1.45954396072891 -1 10.5786401622078 4436 2529 2157 1865 3456 3069 2041 1062 432 2338 2911 2299 M15621 GO_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_P38MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of p38MAPK cascade. 38/45 Gene Ontology BP GO:1900744 1.25579115526445e-06 1.7120410915457e-06 2785 2454.72727272727 2338 1.14162897462581e-07 1246 1.94179225803267 2.33750826997004 1 11.9713998708949 2781 2338 2222 1661 3379 1958 2326 2973 2957 1246 3161 2300 M12125 GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GUANYLATE_CYCLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. 5/10 Gene Ontology BP GO:0031284 3.29957562216846e-07 5.70316692791599e-07 2510 2336.36363636364 2339 3.29957611209252e-08 687 2.68014086620309 -2.58155707250588 -1 17.9472890552565 2509 1128 4344 1023 2704 2339 3263 687 3883 1801 2019 2301 M13023 GO_VITAMIN_D_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_D_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). 11/25 Gene Ontology BP GO:0042359 3.06158683741832e-07 5.38584633440735e-07 4375 2351.54545454545 2339 2.78326114861648e-08 101 4.56540692338539 -4.88779877903219 -1 30.773834463134 4375 1056 1162 258 2606 4439 3755 1529 101 2339 4247 2302 M14214 GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. 53/71 Gene Ontology BP GO:0043124 1.50510244837749e-07 3.26796159230072e-07 2340 2603.63636363636 2340 1.36827504667927e-08 1760 1.56732225815625 -1.60136701150714 -1 10.857525700474 2340 2288 3285 1813 2091 3318 3622 2994 1760 3092 2037 2303 M16214 GO_RUFFLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RUFFLE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. 27/42 Gene Ontology BP GO:0031529 6.98539510938044e-07 1.04143042114538e-06 2075 2252.90909090909 2340 6.35036120669985e-08 384 1.7787262764731 -1.225563418766 -1 11.3710026120006 2075 2779 2835 3109 3086 1296 384 1162 2340 3530 2186 2304 M12464 GO_L_AMINO_ACID_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_AMINO_ACID_IMPORT.html The directed movement of L-enantiomer amino acids into a cell or organelle. 10/23 Gene Ontology BP GO:0043092 2.82587034779321e-07 5.0630630451605e-07 3100 2228 2342 2.56897337342956e-08 745 2.80384698250886 2.12843645741671 1 18.9373471176294 3097 1073 1108 2239 2552 2713 2342 3646 933 745 4060 2305 M16550 GO_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PROCESS.html The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. 1201/1538 Gene Ontology BP GO:0022402 1.91853406939379e-07 3.87285857912769e-07 440 2356 2343 1.9185342350286e-08 439 1.58612060429239 1.69828052565145 1 10.8628538940176 439 3290 4634 3459 2343 773 875 1889 2475 3957 1782 2306 M13521 GO_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_REMODELING.html Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity. 45/59 Gene Ontology BP GO:0046850 9.81573315043891e-08 2.56876301175434e-07 2775 2144.81818181818 2344 8.92339417126109e-09 445 3.00332304297768 3.00863138375409 1 21.2478370776978 2774 1759 445 793 1713 2344 2566 3837 3065 553 3744 2307 M14681 GO_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAMETE_GENERATION.html The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. 529/1037 Gene Ontology BP GO:0007276 7.37997629691624e-08 2.26660262109249e-07 1250 2580.72727272727 2345 7.37997654200448e-09 1247 1.88932522404262 1.90008209550163 1 13.4354198662647 1247 4092 4511 4110 1513 1322 1485 2383 2345 3226 2154 2308 M16655 GO_RESPONSE_TO_IRON_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IRON_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. 34/50 Gene Ontology BP GO:0010039 1.06120838652043e-07 2.65752334514745e-07 2025 2377 2345 9.64734943372421e-09 1770 2.22865812165197 2.3477793747531 1 15.7025999163918 2024 2345 1770 2560 1787 2816 3174 2704 2009 2159 2799 2309 M15471 GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOSINE_1_PHOSPHATE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. 11/14 Gene Ontology BP GO:0003376 3.52477799452631e-07 6.02084875496729e-07 3340 2379.09090909091 2346 3.20434414477858e-08 698 2.58386964747379 -2.8195815309132 -1 17.2329081499749 3338 1054 1738 1371 2685 3973 3922 698 3620 2346 1425 2310 M11349 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. 32/41 Gene Ontology BP GO:0030835 4.28290969406891e-06 5.13882898568918e-06 4040 2410.36363636364 2347 3.89356184723845e-07 238 2.09369996443362 -2.42370341220467 -1 11.8381644236498 4036 2347 2237 1337 3853 3952 2802 792 238 2224 2696 2311 M13495 GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 682/869 Gene Ontology BP GO:0051347 7.28953263882823e-08 2.25729558068868e-07 2870 2556.54545454545 2348 7.28953287794603e-09 852 2.00032211698729 2.1524379052981 1 14.2352460575953 2868 2112 4429 852 1497 2138 2521 3557 2348 1902 3898 2312 M16897 GO_FATTY_ACID_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_ELONGATION.html The elongation of a fatty acid chain by the sequential addition of two-carbon units. 11/13 Gene Ontology BP GO:0030497 5.63905656215031e-08 2.06162496199217e-07 4355 2999 2349 5.12641518790096e-09 1149 2.48134184771454 2.94819943173266 1 17.7910626325164 4355 2057 1615 2316 1149 4559 4530 3916 1725 2349 4418 2313 M11731 GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 65/100 Gene Ontology BP GO:0032370 1.05453488693046e-07 2.64761392764306e-07 2790 2084.18181818182 2350 9.58668124979911e-09 280 2.55010340532559 3.29689797901233 1 17.9882051893704 2786 280 886 1408 1782 3192 3364 2915 2901 1062 2350 2314 M14680 GO_RESPONSE_TO_YEAST http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_YEAST.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. 11/22 Gene Ontology BP GO:0001878 9.35526509254473e-07 1.33078717443016e-06 2315 2333.27272727273 2350 8.5047900643397e-08 1054 3.45131663582571 2.4881222286548 1 21.7732437241905 2313 3244 1054 2350 3240 1448 1157 3874 2434 1790 2762 2315 M11306 GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. 20/24 Gene Ontology BP GO:0060644 2.12957839413654e-07 4.13733956906777e-07 2355 2427.72727272727 2352 1.93598054570697e-08 671 2.58050406801768 1.77180778851898 1 17.6640863549469 4129 2433 1489 1227 2352 4579 3841 2353 671 2246 1385 2316 M11676 GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION.html Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. 38/49 Gene Ontology BP GO:0097035 1.44047586160607e-07 3.1856151064891e-07 2560 2319.72727272727 2352 1.30952359629357e-08 1053 2.31667999253902 -1.92157695289913 -1 16.130439167466 2556 1793 1380 2352 2048 2446 3141 2209 3370 1053 3169 2317 M16723 GO_PEPTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_TRANSPORT.html The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 65/102 Gene Ontology BP GO:0015833 2.17634488710964e-08 1.97691467186943e-07 2730 1765 2353 1.97849537149007e-09 163 2.3490958985151 -2.15256557407207 -1 16.8830360356683 2560 262 853 1489 163 2440 3317 2727 2727 524 2353 2318 M14037 GO_RESPONSE_TO_LIPID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. 920/1440 Gene Ontology BP GO:0033993 3.01558855350545e-11 7.54383523626929e-10 2355 2111.72727272727 2354 3.01558855354638e-12 88 2.28425687461184 2.35418974981901 1 22.3758445214113 2354 1190 4469 690 837 1786 2734 3510 2527 88 3044 2319 M15287 GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. 30/42 Gene Ontology BP GO:0071392 3.07018606380039e-07 5.39689299390374e-07 2270 2428 2354 2.79107862932449e-08 1081 2.62184313202669 2.46103637212692 1 17.622275540636 2269 2354 1081 1533 2608 3228 2898 4547 1142 1647 3401 2320 M16035 GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYUBIQUITINATION.html Any process that modulates the frequency, rate or extent of protein polyubiquitination. 16/20 Gene Ontology BP GO:1902914 1.98176225863577e-06 2.54236001914316e-06 910 2169.09090909091 2354 1.80160367619227e-07 96 2.18382123508356 -2.4322600830094 -1 13.0729116765889 906 3203 2460 1615 3593 2354 2043 2447 96 3265 1878 2321 M11115 GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 186/228 Gene Ontology BP GO:0044272 1.65726074622301e-08 1.97691467186943e-07 3945 2528.54545454545 2356 1.50660068973378e-09 53 2.20605443289693 2.51159913258892 1 15.8481051593753 3941 2171 818 1677 53 4525 4044 3334 2356 803 4092 2322 M14129 GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_CATION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. 282/476 Gene Ontology BP GO:0072507 1.78870088768467e-09 3.21344603490223e-08 2645 1877.72727272727 2356 1.62609171739906e-10 193 2.40967405839375 2.64863117233946 1 19.3732442881827 2645 1377 193 1103 935 2371 3341 3485 2599 250 2356 2323 M12335 GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SUGAR_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 34/35 Gene Ontology BP GO:0009225 1.16408930560303e-06 1.60027604188744e-06 1195 2466.36363636364 2357 1.05826356505437e-07 1194 1.21675334665298 -1.1874468176785 -1 7.49771313339761 1194 3099 3665 2895 3350 1273 1489 1916 3737 2155 2357 2324 M11511 GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 47/83 Gene Ontology BP GO:0048260 9.29477798518709e-08 2.50571274421063e-07 3055 2836.90909090909 2359 8.44979852534736e-09 1658 2.1483424279851 1.7507425137202 1 15.1918681405809 3051 1756 2064 1939 1658 3764 4178 2359 3709 2239 4489 2325 M12076 GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 23/34 Gene Ontology BP GO:0072529 2.33610294427575e-07 4.40955339112988e-07 2205 2120.81818181818 2359 2.12373017485307e-08 182 2.50316593686717 3.00073678139062 1 17.0565415573494 2205 2804 1946 2700 2420 2922 3863 182 460 2359 1468 2326 M11219 GO_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_METABOLIC_PROCESS.html The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. 1539/2124 Gene Ontology BP GO:0044281 2.72665706125245e-08 1.97691467186943e-07 2220 2484.27272727273 2360 2.72665709470841e-09 408 1.91559184302581 -1.79020421305351 -1 13.7465557843983 2217 2094 4286 3261 408 2360 2664 3136 2214 1372 3315 2327 M10753 GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. 29/36 Gene Ontology BP GO:0045932 8.23393687857496e-08 2.37677062514889e-07 660 2353.81818181818 2361 7.48539744249676e-09 657 2.34657606345525 2.14008527567736 1 16.6622063269768 3512 658 978 2728 1529 2361 3390 4263 2261 657 3555 2328 M11663 GO_CYTOKINETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINETIC_PROCESS.html A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). 18/20 Gene Ontology BP GO:0032506 2.85575622231877e-07 5.10298947029771e-07 3915 2326.45454545455 2362 2.59614235728752e-08 517 1.71138745903594 -1.54531006851979 -1 11.5084445685105 3912 864 2652 1530 2560 2590 2161 4126 517 2317 2362 2329 M13891 GO_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 53/61 Gene Ontology BP GO:0071616 8.21979563899156e-08 2.37677062514889e-07 1055 2413.36363636364 2363 7.47254176918674e-09 1053 1.83821016320287 -1.64162120162052 -1 13.0279782884785 1053 3663 3202 3930 1524 1651 1263 1632 2804 3462 2363 2330 M14010 GO_RESPONSE_TO_CARBOHYDRATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CARBOHYDRATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. 192/256 Gene Ontology BP GO:0009743 3.21457557504387e-08 1.97691467186943e-07 1975 2293.72727272727 2363 2.92234147455846e-09 482 2.06893885679188 2.18927827833661 1 14.8560491655517 1974 4101 2363 2928 482 1489 1586 2981 1723 3042 2562 2331 M15159 GO_RESPONSE_TO_DEXAMETHASONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DEXAMETHASONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 32/45 Gene Ontology BP GO:0071548 2.69978868427056e-07 4.88038723695062e-07 1215 2169.63636363636 2364 2.45435365052944e-08 336 1.77832721397552 1.52143220789757 1 12.0001894478258 1211 3108 2364 2884 2532 963 336 1881 3581 3174 1832 2332 M15448 GO_THIOESTER_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 53/61 Gene Ontology BP GO:0035384 8.21979563899156e-08 2.37677062514889e-07 1055 2410.81818181818 2364 7.47254176918674e-09 1054 1.83821016320287 -1.64162120162052 -1 13.0279782884785 1054 3664 3203 3931 1525 1652 1264 1594 2805 3463 2364 2333 M14197 GO_CELLULAR_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 28/32 Gene Ontology BP GO:0036315 4.73310598744235e-08 1.98252330758246e-07 3140 2534 2366 4.30282371751904e-09 958 2.61368097514696 2.89617138892583 1 18.7938863145472 3140 1875 1422 2366 958 3669 3143 4058 3723 1678 1842 2334 M15867 GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 23/28 Gene Ontology BP GO:0048261 2.52243408800388e-07 4.63176235654383e-07 2690 2365.36363636364 2366 2.29312216110579e-08 790 1.77193824874398 -1.19738108871641 -1 12.0000955031545 2690 790 2766 1630 2493 3314 4211 1742 1943 2366 2074 2335 M10227 GO_POSITIVE_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA replication. 91/115 Gene Ontology BP GO:0045740 4.61481769944401e-07 7.42744612781494e-07 1495 2420.54545454545 2367 4.19528969769905e-08 523 1.77548857346461 1.61523944117678 1 11.6313738560757 1492 3632 3403 1670 2855 1519 523 2280 2367 3552 3333 2336 M13365 GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation. 33/65 Gene Ontology BP GO:0046637 2.16775914731205e-07 4.18704164069861e-07 1405 2399.54545454545 2367 1.97069032810105e-08 1403 1.70868248724286 -1.99032023192705 -1 11.6485130433365 1403 2371 2783 3966 2367 1485 1924 1621 3942 2994 1539 2337 M11332 GO_GANGLIOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GANGLIOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. 20/27 Gene Ontology BP GO:0001573 2.65025759116948e-07 4.80766026187587e-07 2925 2382.09090909091 2368 2.40932537312376e-08 840 2.18379103049617 2.2684091392965 1 14.777422061957 2924 840 1541 2243 2523 3687 3397 2368 1721 1160 3799 2338 M13295 GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 45/69 Gene Ontology BP GO:0060393 7.68595980869841e-06 8.93622463515085e-06 1065 2243.90909090909 2370 6.98726060058001e-07 759 2.03975132890674 2.04801756046587 1 11.0012491947758 1065 3921 2111 2531 3975 805 759 3315 2370 2869 962 2339 M16351 GO_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_KILLING.html Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism. 66/138 Gene Ontology BP GO:0031341 2.17019223474893e-07 4.18826398518739e-07 2735 2445.09090909091 2370 1.97290222620709e-08 286 1.88941246097756 -1.51472952034711 -1 12.8922981999863 2734 286 1788 3390 2370 1642 2785 4065 4308 1287 2241 2340 M16209 GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding. 53/70 Gene Ontology BP GO:2000677 4.86582107037458e-05 5.23604658659873e-05 440 2116.81818181818 2372 4.42357153896793e-06 436 1.79466634521557 -1.6468763354742 -1 8.1785949764035 436 3065 2372 3515 4308 867 1051 789 3329 3094 459 2341 M16261 GO_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. 123/170 Gene Ontology BP GO:0030217 1.5773470386681e-07 3.36831671724905e-07 2920 2392.63636363636 2372 1.43395195614554e-08 1145 2.07962216852037 2.21847243584962 1 14.4139360523273 2918 1604 1554 1387 2126 2769 2372 3419 3118 1145 3907 2342 M16792 GO_LUNG_ALVEOLUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_ALVEOLUS_DEVELOPMENT.html The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. 48/56 Gene Ontology BP GO:0048286 8.24948325728662e-08 2.37677062514889e-07 2375 2328.63636363636 2372 7.49953051511172e-09 1372 2.84749236288372 2.89573720400585 1 20.2431783383175 2372 2709 1372 2341 1534 2439 2527 2940 3524 1594 2263 2343 M15668 GO_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_RESORPTION.html The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. 30/39 Gene Ontology BP GO:0045453 1.56896675609724e-05 1.76636881590139e-05 1405 2566.63636363636 2373 1.42634358687046e-06 1388 1.65381110677554 -1.60039688729321 -1 8.37012537723944 1401 2373 2933 2182 4109 1986 1388 2639 4130 2974 2118 2344 M16883 GO_POSITIVE_REGULATION_OF_GLIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIOGENESIS.html Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. 52/67 Gene Ontology BP GO:0014015 6.89558763828233e-07 1.02870052199191e-06 4650 2539.81818181818 2373 6.26871799964301e-08 1065 2.34352113456678 2.78625960219652 1 15.0310317539896 4650 1739 1258 1065 3083 3711 2373 3731 1549 1103 3676 2345 M10418 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 57/100 Gene Ontology BP GO:0042509 2.1778800730673e-07 4.19613912214582e-07 1730 2650.27272727273 2374 1.97989117151417e-08 975 2.16411970635325 -2.04834779975984 -1 14.7812855867611 3615 1727 1726 1258 2374 4095 4316 3534 2189 975 3344 2346 M13286 GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 85/104 Gene Ontology BP GO:0042158 8.9916268424583e-08 2.4768192782905e-07 1355 2290.09090909091 2374 8.17420655450488e-09 446 1.51801982006659 -1.26644210134117 -1 10.7096507524838 1354 3635 3721 3418 1619 446 469 2374 3081 4048 1026 2347 M14627 GO_CERAMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CERAMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. 65/80 Gene Ontology BP GO:0006672 9.27356000847762e-08 2.50341608610761e-07 3135 2099.72727272727 2374 8.43050945398343e-09 269 1.72732771979774 -1.62952433847266 -1 12.1932675885679 3132 269 2515 2705 1655 2374 2645 2627 1797 1222 2156 2348 M12736 GO_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION.html The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 121/184 Gene Ontology BP GO:0042113 1.73335369495697e-07 3.60278591263368e-07 4465 2713.36363636364 2377 1.57577621047804e-08 38 2.16614025173539 -1.94572083396144 -1 14.9499786936982 4461 38 1456 1026 2194 4160 3882 4352 2377 1714 4187 2349 M15571 GO_RESPONSE_TO_SALT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. 12/19 Gene Ontology BP GO:1902074 8.06609201408691e-05 8.58059582568504e-05 2350 2637.09090909091 2377 7.33307978627809e-06 1557 1.96500273491546 -2.4021438088689 -1 8.51066263291228 2346 2531 2393 2377 4360 3921 3281 1951 2259 1557 2032 2350 M12024 GO_SOMATIC_CELL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_CELL_DNA_RECOMBINATION.html Recombination occurring within or between DNA molecules in somatic cells. 30/36 Gene Ontology BP GO:0016444 1.64137376533855e-06 2.15499777937931e-06 465 2260.09090909091 2378 1.49215908175845e-07 356 1.43694068530574 1.47971324098717 1 8.67454550795532 462 3969 3479 3729 3512 910 356 727 2378 3539 1800 2351 M14068 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_GERMLINE_RECOMBINATION_WITHIN_A_SINGLE_LOCUS.html The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. 30/36 Gene Ontology BP GO:0002562 1.64137376533855e-06 2.15499777937931e-06 465 2254.90909090909 2379 1.49215908175845e-07 357 1.43694068530574 1.47971324098717 1 8.67454550795532 463 3970 3480 3730 3513 911 357 660 2379 3540 1801 2352 M10349 GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION.html A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. 65/78 Gene Ontology BP GO:0061572 8.74713845116316e-08 2.45512816355666e-07 2685 2303.45454545455 2380 7.95194436267905e-09 677 1.88124518301685 1.85903909106416 1 13.3070282781612 2685 1707 2380 1321 1581 2990 3271 2919 677 2279 3528 2353 M15692 GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 38/54 Gene Ontology BP GO:0006213 3.38136580338992e-07 5.80786086495877e-07 2105 2381.81818181818 2380 3.07396938463701e-08 515 1.65847762841687 2.15152709553332 1 11.0485728877446 2105 515 2716 2261 2667 3629 4527 1830 606 2380 2964 2354 M10522 GO_RESPONSE_TO_MUSCLE_STRETCH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MUSCLE_STRETCH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. 27/33 Gene Ontology BP GO:0035994 2.06244010895363e-07 4.05879276381118e-07 4490 2789 2381 1.87494572936527e-08 866 2.30031638207239 -1.5005185713206 -1 15.7545291132742 4486 2381 1848 1611 2323 4231 3193 4293 866 2206 3241 2355 M11343 GO_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_ARREST.html A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). 176/219 Gene Ontology BP GO:0007050 2.82292458235708e-08 1.97691467186943e-07 2285 2405.81818181818 2381 2.56629510779943e-09 359 1.81676976136881 2.02922242777764 1 13.0315601492209 2284 3324 3379 2444 359 1303 2077 3734 2381 3537 1642 2356 M16248 GO_NEGATIVE_REGULATION_OF_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_KILLING.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing. 36/80 Gene Ontology BP GO:0031342 1.01462014174424e-06 1.42156805767417e-06 1010 2381.27272727273 2381 9.22382372434719e-08 1008 1.68052427330122 -1.46204597995262 -1 10.4918796777255 1008 1815 2381 3413 3283 1258 2571 1673 4491 2454 1847 2357 M15885 GO_NAD_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. 11/16 Gene Ontology BP GO:0009435 1.83775332835739e-06 2.37661651941272e-06 1720 2699.36363636364 2382 1.67068623955682e-07 1706 2.22657817439353 -2.44202354447934 -1 13.4014346596783 1720 3551 2611 3649 3566 2021 1972 4167 2382 2348 1706 2358 M10299 GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BUNDLE_OF_HIS_CELL_TO_PURKINJE_MYOCYTE_COMMUNICATION.html The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 11/22 Gene Ontology BP GO:0086069 2.52224481906645e-07 4.63176235654383e-07 4580 2453.81818181818 2383 2.29295009839594e-08 1044 3.25433624601742 -1.96706060780109 -1 22.1339550381866 4576 1044 1383 1135 2492 4585 3477 1571 2566 1780 2383 2359 M10794 GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. 33/44 Gene Ontology BP GO:0051145 4.8722717608857e-06 5.79220247915206e-06 2385 2595.09090909091 2384 4.42934777398936e-07 1597 2.25477425695833 2.35922119481825 1 12.6311207055578 2384 3413 1703 1597 3886 2025 1838 2570 3912 2032 3186 2360 M15071 GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that activates or increases the frequency, rate or extent of fatty acid oxidation. 17/23 Gene Ontology BP GO:0046321 3.43657927393325e-07 5.88315061133606e-07 2595 2324.72727272727 2384 3.12416346432278e-08 1448 2.07016578213158 2.41769378379673 1 13.8067654709766 2593 2475 2087 1983 2678 2384 1448 2340 2701 2129 2754 2361 M14642 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 72/84 Gene Ontology BP GO:0010803 6.87788602820551e-07 1.02671811643376e-06 920 2082.36363636364 2385 6.25262561677098e-08 663 1.58961009779245 -1.53151304292278 -1 10.1606006372459 918 2671 2996 2015 3081 663 710 2385 3221 3578 668 2362 M15275 GO_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BASED_MOVEMENT.html A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules. 217/278 Gene Ontology BP GO:0007018 4.7720311723455e-08 1.98252330758246e-07 2090 2425.54545454545 2386 4.33821025077807e-09 973 1.67422073959149 1.97825418951246 1 11.9979690593535 2086 2160 3292 3353 973 1628 3443 2547 2386 3350 1463 2363 M10249 GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEPATICOBILIARY_SYSTEM_DEVELOPMENT.html The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. 147/195 Gene Ontology BP GO:0061008 5.144870264921e-08 2.03397493965704e-07 4245 2837.27272727273 2387 4.67715489567071e-09 1039 1.97467965386052 -1.80588314225708 -1 14.1477308956267 4241 2195 2278 2130 1039 4550 4199 2778 1450 2387 3963 2364 M10050 GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. 47/50 Gene Ontology BP GO:0048008 2.22150556941059e-07 4.25377177550102e-07 1365 2278.72727272727 2388 2.01955072157523e-08 476 1.48319108526789 1.58813648888358 1 10.0853649577375 1363 476 3172 2920 2388 2112 1517 2183 3687 2516 2732 2365 M11501 GO_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that modulates the frequency, rate or extent of the process of creating protein polymers. 184/225 Gene Ontology BP GO:0032271 4.24094793693712e-08 1.97691467186943e-07 3525 2272.72727272727 2388 3.85540728971821e-09 799 1.95174942792146 -1.73893934606837 -1 14.0081624511014 3521 2169 2078 1009 799 2451 2630 4562 890 2388 2503 2366 M11222 GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. 28/31 Gene Ontology BP GO:1903392 5.26916331557479e-08 2.04581932255101e-07 3050 2440.81818181818 2390 4.79014858343198e-09 1071 1.75037987908312 1.51447836534051 1 12.5231092793589 3049 2390 3028 2004 1071 2036 2216 3518 2416 3036 2085 2367 M15528 GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation. 26/55 Gene Ontology BP GO:0046638 5.17814099387869e-08 2.03840017297103e-07 2110 2444.45454545455 2390 4.70740101432419e-09 993 1.59523779571369 -1.80419591943958 -1 11.4058359960484 2110 2791 2860 3940 1047 1932 2390 1896 4109 2821 993 2368 M13196 GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRASPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of the same species. 41/65 Gene Ontology BP GO:0051703 3.82063889242346e-07 6.4062820779987e-07 4045 2397.54545454545 2391 3.47330868721493e-08 492 2.3196899921294 2.25760334650845 1 15.39195544322 4045 492 1324 1186 2740 3513 4593 2391 1898 1352 2839 2369 M14411 GO_LAMELLIPODIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAMELLIPODIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. 43/46 Gene Ontology BP GO:0097581 4.32709152610083e-08 1.97691467186943e-07 4335 2543.18181818182 2394 3.93371964655332e-09 457 1.78493969901053 -1.60467691912855 -1 12.8012638908139 4333 457 2394 1720 828 4556 3850 2012 3353 1795 2677 2370 M14295 GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. 26/34 Gene Ontology BP GO:0055094 4.54042642197955e-08 1.97760774550163e-07 4570 2765.09090909091 2395 4.12766046880567e-09 908 2.39874196249908 2.53579500904896 1 17.2418401961472 4566 2395 1573 1974 908 3955 3379 1725 3858 1710 4373 2371 M16689 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. 18/23 Gene Ontology BP GO:0034391 5.19697095732601e-08 2.03844518708446e-07 2945 2086.18181818182 2395 4.72451916371995e-09 322 2.15387532857564 -1.52535408867501 -1 15.4396378185966 2942 2855 2638 322 1051 2395 513 4417 509 3488 1818 2372 M12501 GO_METALLO_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_METALLO_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. 21/22 Gene Ontology BP GO:0031163 2.27080424034949e-07 4.33034923374843e-07 720 2483.27272727273 2396 2.06436770430749e-08 720 1.02451472370632 -1.07472769357981 -1 6.92292600758561 720 3468 3765 3933 2396 1619 1681 873 3747 3509 1605 2373 M15883 GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. 17/22 Gene Ontology BP GO:0043649 5.94186548840306e-07 9.08262158920481e-07 385 1908.63636363636 2396 5.40169735746472e-08 140 1.84733281324968 -1.82436285925114 -1 11.9324149539399 381 3180 2396 3308 3001 354 140 855 3946 2602 832 2374 M16568 GO_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_AGING.html Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 46/53 Gene Ontology BP GO:0090342 9.95932416039102e-08 2.57738316115422e-07 1865 2677.81818181818 2396 9.05393146476932e-09 1617 1.69203066408796 2.0171918966637 1 11.9187006537675 2396 3673 3077 3558 1729 2388 1617 1861 3272 4022 1863 2375 M11056 GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TIMING_OF_CELL_DIFFERENTIATION.html The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. 10/18 Gene Ontology BP GO:0048505 9.17012629533383e-07 1.30965615875348e-06 3205 2124.18181818182 2397 8.33648192514915e-08 42 2.45475501215603 2.59056957333168 1 15.472016809323 3201 1066 1790 649 3225 2397 1591 3420 42 2676 3309 2376 M12539 GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. 125/222 Gene Ontology BP GO:0071346 4.25218215553093e-07 6.93308123521039e-07 840 2190.81818181818 2397 3.86562088854291e-08 609 1.82909527056629 -1.75844012770223 -1 12.0450197357514 837 1603 1797 3386 2815 1828 2397 2502 3923 609 2402 2377 M13340 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 274/356 Gene Ontology BP GO:0090068 2.80499800765622e-07 5.02760236118043e-07 620 1980.45454545455 2397 2.54999851390298e-08 554 1.74873278608233 1.85732508417399 1 11.774244947873 620 3312 3059 2592 2551 554 731 1795 2397 2941 1233 2378 M13758 GO_IRON_SULFUR_CLUSTER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_SULFUR_CLUSTER_ASSEMBLY.html The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. 21/22 Gene Ontology BP GO:0016226 2.27080424034949e-07 4.33034923374843e-07 725 2481.63636363636 2397 2.06436770430749e-08 721 1.02451472370632 -1.07472769357981 -1 6.92292600758561 721 3469 3766 3934 2397 1620 1682 843 3748 3512 1606 2379 M14964 GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC.html Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. 10/18 Gene Ontology BP GO:0040034 9.17012629533383e-07 1.30965615875348e-06 3205 2125.09090909091 2398 8.33648192514915e-08 43 2.45475501215603 2.59056957333168 1 15.472016809323 3202 1067 1791 650 3226 2398 1592 3412 43 2685 3310 2380 M12830 GO_LYMPHANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHANGIOGENESIS.html Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. 13/15 Gene Ontology BP GO:0001946 0.000141176282032275 0.000147982257331871 3640 2296.36363636364 2399 1.28350311158828e-05 284 3.81292011140572 -3.46430608183369 -1 15.6465792929524 3639 3230 1832 756 4430 3017 1644 796 284 3233 2399 2381 M10674 GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOLIPID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). 47/65 Gene Ontology BP GO:0009247 4.01423635902862e-07 6.67556889869913e-07 1565 2475.72727272727 2400 3.64930644680692e-08 944 1.62991361912108 -1.30391486092496 -1 10.7499614474815 1564 3670 3180 3331 2762 1324 944 2092 2400 3663 2303 2382 M12180 GO_WATER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_WATER_TRANSPORT.html The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/21 Gene Ontology BP GO:0006833 7.80547617383038e-07 1.13887991962473e-06 2400 1952.81818181818 2400 7.09588994833707e-08 527 4.49973539495038 4.33398219084336 1 28.7501675402437 2400 1040 756 696 3155 3062 2474 3368 527 1304 2699 2383 M15691 GO_POSITIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_STORAGE.html Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 24/29 Gene Ontology BP GO:0010884 4.20844808989397e-07 6.88534070403538e-07 460 2160 2400 3.82586263176477e-08 460 1.88942807647395 -1.98563679261269 -1 12.4521750245985 460 3144 2400 3073 2808 947 912 3040 4013 1745 1218 2384 M11609 GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 865/1229 Gene Ontology BP GO:1901701 2.98235001491076e-08 1.97691467186943e-07 2745 2242 2401 2.98235005493561e-09 180 2.15308884524583 2.40275430167237 1 15.4648895525984 2741 1201 4315 708 512 2401 2948 4101 2291 180 3264 2385 M13730 GO_ECTODERMAL_PLACODE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_DEVELOPMENT.html The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0071696 1.84861290538178e-07 3.77428514644205e-07 3830 2458.81818181818 2401 1.68055732792435e-08 1128 1.91026180826647 2.08530249853559 1 13.1289941678632 3827 2489 2707 1631 2234 3501 1936 2087 1128 2401 3106 2386 M15790 GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_DEVELOPMENT.html The progression of the atrioventricular valve over time, from its formation to the mature structure. 23/30 Gene Ontology BP GO:0003171 3.48188132055391e-05 3.78267424341287e-05 3035 2394.45454545455 2401 3.16539675325629e-06 1168 2.47938112413054 2.90305623794786 1 11.7199435943906 3035 2412 1835 1519 4261 2198 2401 3001 1168 2742 1767 2387 M12099 GO_RESPONSE_TO_MAGNESIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MAGNESIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. 25/45 Gene Ontology BP GO:0032026 1.74299409923304e-07 3.62060336773721e-07 4005 2805.09090909091 2402 1.58454021575024e-08 1574 2.43023202440061 -2.56009919857538 -1 16.7808215246605 4002 2402 1574 2329 2196 3588 3018 4296 2007 1588 3856 2388 M16147 GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIOVENTRICULAR_VALVE_MORPHOGENESIS.html The process in which the structure of the atrioventricular valve is generated and organized. 23/26 Gene Ontology BP GO:0003181 3.48188132055391e-05 3.78267424341287e-05 3040 2392.72727272727 2402 3.16539675325629e-06 1169 2.47938112413054 2.90305623794786 1 11.7199435943906 3036 2413 1836 1520 4262 2199 2402 2972 1169 2743 1768 2389 M11624 GO_RESPONSE_TO_MURAMYL_DIPEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MURAMYL_DIPEPTIDE.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. 20/24 Gene Ontology BP GO:0032495 8.04967288638459e-05 8.56508756925394e-05 1730 2405.72727272727 2404 7.31815221304807e-06 1727 1.9210369693886 -1.78653917775187 -1 8.31933995292891 1727 1953 2519 2003 4358 2404 1813 2491 1776 2663 2756 2390 M12974 GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCAGON_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. 31/43 Gene Ontology BP GO:0071377 1.18459422419588e-07 2.83555629517774e-07 2405 2560.90909090909 2404 1.07690389816417e-08 1546 1.87610951004661 2.03262863482172 1 13.1437151598447 2404 1848 2327 1546 1882 3032 3570 4304 1731 3080 2446 2391 M14980 GO_VACUOLE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VACUOLE_FUSION.html Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. 24/25 Gene Ontology BP GO:0097576 9.68083747037295e-06 1.11249535069512e-05 420 2202 2404 8.80080006364132e-07 273 1.12518984299898 -0.918795069438263 -1 5.90238204076979 420 2404 3630 3147 4022 390 273 2030 2597 3521 1788 2392 M15688 GO_ECTODERMAL_PLACODE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_MORPHOGENESIS.html The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0071697 1.84861290538178e-07 3.77428514644205e-07 3830 2459.72727272727 2404 1.68055732792435e-08 1129 1.91026180826647 2.08530249853559 1 13.1289941678632 3828 2490 2708 1632 2235 3502 1937 2085 1129 2404 3107 2393 M12858 GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 20/38 Gene Ontology BP GO:0051354 1.84239269420397e-05 2.05776601203339e-05 2760 2489.09090909091 2405 1.67491647593186e-06 561 1.77031277372583 -1.50734169623734 -1 8.84102143716808 2758 3997 2923 2405 4146 2204 1856 1671 1457 3402 561 2394 M14221 GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is decreased. 24/46 Gene Ontology BP GO:0045776 8.16595855473831e-08 2.37283824319446e-07 3110 2350 2405 7.42359896167484e-09 916 2.79275190010883 2.94832124773217 1 19.8540148613912 3107 3139 1203 3623 1519 2405 2486 2070 3000 916 2382 2395 M13793 GO_REGULATION_OF_SENSORY_PERCEPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION.html Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. 28/63 Gene Ontology BP GO:0051931 4.2352165147188e-07 6.92183436704832e-07 2575 2055.09090909091 2406 3.85019757276353e-08 203 3.50243715922596 3.64595085924914 1 23.1704992901058 2573 3717 989 2019 2811 2802 3199 203 2406 1110 777 2396 M15785 GO_ECTODERMAL_PLACODE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ECTODERMAL_PLACODE_FORMATION.html The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. 16/22 Gene Ontology BP GO:0060788 1.84861290538178e-07 3.77428514644205e-07 3830 2454.63636363636 2406 1.68055732792435e-08 1130 1.91026180826647 2.08530249853559 1 13.1289941678632 3829 2491 2709 1633 2236 3503 1938 2018 1130 2406 3108 2397 M11975 GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. 386/495 Gene Ontology BP GO:0043623 1.31276370521502e-07 3.00411010867397e-07 2045 2913.36363636364 2407 1.19342162140822e-08 1557 1.66403879150067 -1.58112540786872 -1 11.600161862486 2043 4617 3866 4416 1973 2214 2159 2407 1557 4360 2435 2398 M15823 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein. 16/25 Gene Ontology BP GO:0042523 2.86998282806904e-07 5.12237441465487e-07 2370 2569.09090909091 2407 2.60907563860833e-08 1088 2.44295750631853 -2.65679398583037 -1 16.4719858917959 2366 3204 2048 1443 2565 3586 4651 1088 2288 2407 2614 2399 M16828 GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_ACETYLATION.html Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation. 24/26 Gene Ontology BP GO:2000615 1.03466575755947e-05 1.18491256951125e-05 900 2043.90909090909 2407 9.40609657865129e-07 681 1.33338513680264 1.54787851028665 1 6.97602149673408 899 2407 3196 2625 4039 681 768 709 2583 3522 1054 2400 M16918 GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SENSORY_PERCEPTION_OF_PAIN.html Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. 28/63 Gene Ontology BP GO:0051930 4.2352165147188e-07 6.92183436704832e-07 2575 2051.18181818182 2407 3.85019757276353e-08 149 3.50243715922596 3.64595085924914 1 23.1704992901058 2574 3718 990 2020 2812 2803 3200 149 2407 1112 778 2401 M16225 GO_EPITHELIAL_CELL_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_MATURATION.html The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. 16/25 Gene Ontology BP GO:0002070 5.60319724311876e-08 2.05622555659363e-07 3085 2278.72727272727 2408 5.0938158052973e-09 596 2.57391687153736 -2.79409765005094 -1 18.4622028697925 3083 3201 2148 2774 1143 3907 4002 688 596 2408 1116 2402 M12814 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. 23/35 Gene Ontology BP GO:0045987 2.85015023764847e-08 1.97691467186943e-07 2490 2237.54545454545 2410 2.59104570415712e-09 372 2.83196518290838 2.73455193968779 1 20.376682646967 2490 2410 793 3600 372 3190 3287 1289 3252 1609 2321 2403 M15279 GO_RESPONSE_TO_HYDROPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HYDROPEROXIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. 20/26 Gene Ontology BP GO:0033194 0.000109764099711857 0.000115681167827695 2075 2731.45454545455 2411 9.97905241178933e-06 1864 2.42624135978519 -2.37209787775486 -1 10.1951547617451 2073 4006 2399 2411 4399 2794 2377 2013 1864 3059 2651 2404 M15928 GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 18/27 Gene Ontology BP GO:0030949 0.00331897538168191 0.00338221472863905 925 2633.27272727273 2411 0.000302181188403322 609 1.90549308393387 2.01983254505847 1 4.96802133304766 922 4025 2411 3777 4651 1186 609 1837 4413 2768 2367 2405 M16083 GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_VESICLE_RECYCLING_WITHIN_GOLGI.html The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. 19/21 Gene Ontology BP GO:0000301 2.31293053821568e-07 4.3801651584524e-07 660 2392.09090909091 2411 2.10266434671047e-08 172 0.873756190481295 -0.843925126539606 -1 5.88288259912698 658 4008 3822 4533 2411 508 172 911 4388 4052 850 2406 M11364 GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. 20/25 Gene Ontology BP GO:0050774 3.62313313871153e-06 4.39823597558695e-06 4625 2198.27272727273 2412 3.29376282326008e-07 151 1.83327409187403 1.45949726474334 1 10.485320982536 4625 845 2412 620 3806 4016 2619 1418 151 2662 1007 2407 M14460 GO_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE.html The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. 1438/1842 Gene Ontology BP GO:0007049 2.10781475421036e-07 4.11158538761594e-07 475 2432.90909090909 2413 2.10781495414012e-08 472 1.58701778937602 1.70330295918068 1 10.8245689014375 472 3582 4495 3518 2413 794 869 1975 2615 4224 1805 2408 M11446 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 41/63 Gene Ontology BP GO:0010719 3.24377975931059e-07 5.625835754579e-07 2935 2526.81818181818 2414 2.94889112508026e-08 1792 1.89167696264861 2.00362499365466 1 12.6462537486689 2931 1792 2019 2414 2640 2316 2135 3498 2581 2117 3352 2409 M15435 GO_CELLULAR_CHEMICAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CHEMICAL_HOMEOSTASIS.html Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. 491/767 Gene Ontology BP GO:0055082 4.32454322634317e-08 1.97691467186943e-07 3760 2405.81818181818 2414 3.93140301031888e-09 199 2.25296723871527 2.44574592558252 1 16.1875277947987 3759 1276 301 1099 827 3864 4069 4298 2414 199 4358 2410 M15875 GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPOPROTEIN_PARTICLE_CLEARANCE.html Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. 11/17 Gene Ontology BP GO:0010984 7.98455549732389e-07 1.16100427278275e-06 2125 2214.72727272727 2414 7.25868945017706e-08 219 2.58938526771434 3.54823373636852 1 16.4729977948495 2125 3248 2414 3067 3166 2654 1602 857 219 3746 1264 2411 M13400 GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MICROTUBULE_BASED_MOVEMENT.html Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. 21/37 Gene Ontology BP GO:0060632 1.74915936837758e-06 2.27659819330374e-06 1490 1997.45454545455 2415 1.59014614462503e-07 207 1.77492208129117 -1.38759152986101 -1 10.695812451091 1488 2442 2791 2415 3544 1142 1084 840 2832 3187 207 2412 M12909 GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. 90/133 Gene Ontology BP GO:0048259 1.09938253439779e-07 2.70657509658884e-07 4285 2763.81818181818 2416 9.99438717578236e-09 127 1.89397914036092 -1.90444182277875 -1 13.3113109246592 4281 127 2416 1595 1821 4359 4494 2214 3245 2222 3628 2413 M15764 GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE_REGULATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. 294/617 Gene Ontology BP GO:0002768 1.00901553222423e-07 2.59416471284394e-07 3860 2754.90909090909 2417 9.17286889547328e-09 1340 1.64277545419531 -1.45258463282292 -1 11.5634564766048 1509 3859 3858 3834 1742 1340 1935 2417 3754 4401 1655 2414 M15960 GO_MEMBRANE_REPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_REPOLARIZATION.html The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. 13/28 Gene Ontology BP GO:0086009 1.37686281924043e-06 1.84999789140217e-06 2930 2372.90909090909 2417 1.25169425540571e-07 653 3.43178875771213 2.96611891247547 1 21.1195484626989 2927 983 653 1487 3431 2989 2277 4103 2417 960 3875 2415 M10441 GO_DENDRITIC_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_MIGRATION.html The movement of a dendritic cell within or between different tissues and organs of the body. 13/48 Gene Ontology BP GO:0036336 8.66248927880754e-06 1.00190312240347e-05 1965 2188.45454545455 2419 7.87502126136808e-07 311 3.50673632057843 -3.54767777874158 -1 18.8066784238408 1961 3239 1880 1619 3996 2419 2516 891 311 2783 2458 2416 M11425 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE.html Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. 12/29 Gene Ontology BP GO:0042749 2.55516743608311e-05 2.81334455279099e-05 2425 2465.09090909091 2422 2.32290646663254e-06 1408 2.11567939445776 2.32430082686206 1 10.2777271316297 2422 2934 2183 1624 4203 2718 2759 1408 2989 1551 2325 2417 M12146 GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity. 62/127 Gene Ontology BP GO:0001910 2.44765876493818e-07 4.54192233925168e-07 2430 2277.72727272727 2422 2.22514457932539e-08 305 1.91121645373634 -1.51472952034711 -1 12.969764888437 2428 305 1741 2836 2463 1532 2422 3811 4297 1185 2035 2418 M13320 GO_RENAL_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_WATER_HOMEOSTASIS.html Renal process involved in the maintenance of an internal steady state of water in the body. 31/53 Gene Ontology BP GO:0003091 8.37980844993196e-08 2.40389942771476e-07 3425 2421 2422 7.61800797192657e-09 615 1.98543328476607 1.97901632773501 1 14.0698916549234 3424 615 2016 1149 1546 3562 3368 3421 2422 2776 2332 2419 M13155 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. 50/55 Gene Ontology BP GO:0034502 8.63302944732725e-06 9.98744058140569e-06 2100 2313.18181818182 2424 7.84823938583754e-07 880 1.72573196457203 1.45541858087132 1 9.20024014702893 1018 3066 3115 2424 3995 1164 880 2096 2744 2846 2097 2420 M15437 GO_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. 120/149 Gene Ontology BP GO:0050673 2.06472436534302e-07 4.05879276381118e-07 3400 1855.09090909091 2424 1.87702232647246e-08 45 2.62638665964685 2.89693147412802 1 18.0037681804496 3399 45 418 221 2326 2749 3198 2588 2441 597 2424 2421 M13822 GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. 60/84 Gene Ontology BP GO:1904888 2.18863881060995e-06 2.78320207318067e-06 2695 2290.72727272727 2425 1.98967362540843e-07 1160 2.25697439811423 2.55003549252944 1 13.4188681324125 2692 2681 1789 1766 3629 2509 2425 2339 1160 2523 1685 2422 M13970 GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_CELL_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of T cell cytokine production. 34/76 Gene Ontology BP GO:0002724 2.51983163842632e-06 3.16201344432416e-06 200 2146.09090909091 2425 2.29075865871883e-07 196 1.32697244687049 -1.32386326274773 -1 7.7635616947519 196 562 3067 3374 3678 572 1802 2425 4245 2502 1184 2423 M10566 GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. 31/40 Gene Ontology BP GO:0051154 2.34706761308447e-07 4.41501657983249e-07 2775 2252.09090909091 2426 2.13369805771014e-08 644 2.03420771043132 -2.21728792942055 -1 13.8386971032242 2771 644 2095 1242 2426 3613 3306 906 3199 2774 1797 2424 M11560 GO_SULFATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATION.html The addition of a sulfate group to a molecule. 9/26 Gene Ontology BP GO:0051923 2.73579078100751e-07 4.93272836844766e-07 3870 2430 2426 2.73579111781237e-08 102 2.92941848743702 -2.07423255845616 -1 19.8263373704169 3870 2076 4311 1470 2595 4213 2983 325 102 2426 2359 2425 M11634 GO_THIOESTER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_THIOESTER_METABOLIC_PROCESS.html The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. 77/99 Gene Ontology BP GO:0035383 2.06841601607722e-07 4.06090283662756e-07 1000 2506.27272727273 2427 1.88037837322497e-08 996 1.82933081578939 -1.67472440349093 -1 12.5052159534664 996 3641 3237 3489 2327 1769 1714 1301 3099 3569 2427 2426 M15311 GO_ACYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. 77/99 Gene Ontology BP GO:0006637 2.06841601607722e-07 4.06090283662756e-07 1000 2498.72727272727 2428 1.88037837322497e-08 997 1.82933081578939 -1.67472440349093 -1 12.5052159534664 997 3642 3238 3490 2328 1770 1715 1208 3100 3570 2428 2427 M13049 GO_CILIUM_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. 212/278 Gene Ontology BP GO:0044782 4.29683921405454e-08 1.97691467186943e-07 1800 2479 2430 3.90621754361498e-09 818 1.54440806633054 1.51217418837909 1 11.0609740223489 1796 2997 3613 3881 818 1044 1950 2741 2430 3656 2343 2428 M10186 GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. 70/102 Gene Ontology BP GO:0070373 8.56181845599832e-08 2.43720026916741e-07 2880 2164.63636363636 2431 7.78347162654697e-09 243 1.63518731282046 1.69876851139051 1 11.5573571021312 2876 243 2701 2431 1561 1898 1559 2946 3140 1835 2621 2429 M13812 GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. 21/36 Gene Ontology BP GO:0002437 1.1928492560971e-06 1.633890959264e-06 1710 2382.90909090909 2431 1.08440900260498e-07 923 2.37125928598957 1.93230942230491 1 14.6960611417643 1706 2431 1498 3136 3362 1594 923 2835 2830 1995 3902 2430 M14243 GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMIDAZOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. 9/13 Gene Ontology BP GO:0052803 3.9213691809878e-08 1.97691467186943e-07 1715 2618.63636363636 2431 3.92136925018492e-09 823 3.2020527634003 3.66763031055514 1 23.0543332312114 1712 3562 4482 3326 823 2235 2156 3093 2647 2431 2338 2431 M10149 GO_LABYRINTHINE_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_DEVELOPMENT.html The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. 48/64 Gene Ontology BP GO:0060711 2.32344522111151e-08 1.97691467186943e-07 2435 2305.81818181818 2432 2.11222295059063e-09 197 1.7992063839142 -1.80690595275448 -1 12.9044859365706 2432 4161 3089 2441 197 1965 3192 1034 2098 3567 1188 2432 M11377 GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. 82/102 Gene Ontology BP GO:0008652 2.36109231085615e-07 4.41848711172251e-07 2355 2472.63636363636 2433 2.14644778568566e-08 184 2.25288891447428 2.0577891023855 1 15.3377119004137 2351 184 1632 2693 2433 3565 4461 2941 874 2416 3649 2433 M11652 GO_BONE_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_GROWTH.html The increase in size or mass of a bone that contributes to the shaping of that bone. 21/26 Gene Ontology BP GO:0098868 3.51216714617147e-07 6.00371555148268e-07 2120 2374.27272727273 2434 3.19287973351625e-08 1281 2.82019904552391 3.24255362800887 1 18.8231989632435 2120 2434 1320 1966 2683 2574 3260 3503 2546 1281 2430 2434 M14163 GO_RESPONSE_TO_PROGESTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROGESTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. 51/72 Gene Ontology BP GO:0032570 1.33768341671384e-07 3.03769689505589e-07 3240 2482.72727272727 2436 1.21607590731825e-08 408 2.18061913417849 -2.23421811504731 -1 15.2250354158662 3240 408 1465 1922 1991 2436 3372 4599 3727 897 3253 2435 M15684 GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INVOLVED_IN_CELL_FATE_COMMITMENT.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate. 14/30 Gene Ontology BP GO:0060850 7.51260565266016e-05 8.00828272665011e-05 2000 2439 2437 6.82987473358387e-06 316 1.62409925847413 -1.52504477083336 -1 7.06709262780384 1998 4041 3208 3159 4352 2181 316 1490 2437 2960 687 2436 M13353 GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_RECOMBINATION.html Any recombinational process that contributes to the maintenance of proper telomeric length. 32/33 Gene Ontology BP GO:0000722 0.000123348977680573 0.000129763236072283 155 2242.18181818182 2439 1.12141721926429e-05 50 1.12130730723534 1.16429749134941 1 4.59057239074137 155 2756 3585 2439 4488 559 50 1167 4121 3430 1914 2437 M15184 GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACTIN_FILAMENT_DEPOLYMERIZATION.html Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament. 47/59 Gene Ontology BP GO:0030834 1.81547309215757e-07 3.72624450719416e-07 2430 2427.63636363636 2439 1.65043021997559e-08 966 1.98116795786741 1.79656681840869 1 13.6324166583437 2429 2698 2439 1711 2224 2445 3259 2326 966 2519 3688 2438 M10168 GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_NUCLEAR_DIVISION.html Any process that activates or increases the frequency, rate or extent of mitosis. 52/63 Gene Ontology BP GO:0045840 1.49089180015272e-06 1.98316739454277e-06 770 2123.18181818182 2440 1.35535710045308e-07 767 2.10992758654018 2.31264882312999 1 12.8723868402751 767 3372 2440 2938 3465 1352 815 1151 2624 2773 1658 2439 M10840 GO_ICOSANOID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_TRANSPORT.html The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. 20/31 Gene Ontology BP GO:0071715 2.00131724319151e-05 2.2277820891316e-05 3545 2389.27272727273 2440 1.81939586290847e-06 859 3.18156049206208 -3.35716632958594 -1 15.8606337839997 3542 2440 1525 1863 4158 3446 2313 859 1007 2661 2468 2440 M13716 GO_FATTY_ACID_DERIVATIVE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_TRANSPORT.html The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/31 Gene Ontology BP GO:1901571 2.00131724319151e-05 2.2277820891316e-05 3545 2394.18181818182 2441 1.81939586290847e-06 898 3.18156049206208 -3.35716632958594 -1 15.8606337839997 3543 2441 1526 1864 4159 3447 2314 898 1008 2667 2469 2441 M13909 GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. 10/31 Gene Ontology BP GO:0045624 1.31503990992106e-06 1.77667848457105e-06 2445 2773.54545454545 2441 1.19549154180072e-07 1254 1.93260567452601 -2.38302303039888 -1 11.8806592399681 2441 2942 2263 2142 3409 3543 4377 2372 3684 2082 1254 2442 M15339 GO_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G2_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage. 41/46 Gene Ontology BP GO:0031572 9.79805008161916e-08 2.56809599576163e-07 2445 2323.72727272727 2441 8.90731865271906e-09 504 1.41543922263487 1.55454861706723 1 9.95429163978791 2591 504 3023 3065 1709 2442 2173 2019 2272 2441 3322 2443 M11464 GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. 9/20 Gene Ontology BP GO:0007216 5.83375876634661e-07 8.96449126149629e-07 4325 2555.36363636364 2444 5.83376029782052e-08 59 3.08217328270926 -3.15110145982787 -1 20.0030905805033 4325 1063 4304 1469 3051 4349 3659 2128 59 1258 2444 2444 M14453 GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. 21/25 Gene Ontology BP GO:0045605 2.30249485812124e-06 2.91286258152206e-06 2925 2350.54545454545 2444 2.09317933444507e-07 214 3.31639851422421 -3.30291734845778 -1 19.6999960423653 2921 814 914 1008 3648 3641 4304 4653 214 2444 1295 2445 M11711 GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLIC_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 14/17 Gene Ontology BP GO:0009214 2.00305622726133e-05 2.22918455523726e-05 2450 2754.27272727273 2447 1.82097678629292e-06 1439 1.88089401513679 1.85831772591636 1 9.32979388641715 2447 3797 2699 4097 4160 1780 1722 1439 3842 1953 2361 2446 M16427 GO_REGULATED_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATED_EXOCYTOSIS.html A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. 224/351 Gene Ontology BP GO:0045055 2.74293232702276e-08 1.97691467186943e-07 4630 2437 2447 2.49357487383754e-09 267 2.40303350709915 -2.34795186896728 -1 17.2732843897089 4629 1428 267 682 336 4544 4574 3845 2447 574 3481 2447 M10789 GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 11/25 Gene Ontology BP GO:0002281 7.40066039807993e-06 8.61743564371018e-06 1050 2560.54545454545 2448 6.72789572140831e-07 1047 1.36786077863804 -1.31625913826682 -1 7.36349178845793 1047 3246 2891 2448 3969 1641 2798 1359 4501 2331 1935 2448 M13756 GO_VESICLE_COATING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_COATING.html A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. 102/116 Gene Ontology BP GO:0006901 1.33666849878918e-08 1.94969232754421e-07 3170 2513.18181818182 2448 1.21515318810042e-09 24 2.07503559320859 -1.25913657977607 -1 14.9136457324562 3167 1631 2401 1780 24 2974 2448 4390 656 3941 4233 2449 M15081 GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DENDRITE_EXTENSION.html Any process that activates or increases the frequency, rate or extent of dendrite extension. 17/29 Gene Ontology BP GO:1903861 6.204341036008e-07 9.40351753763688e-07 3240 2464.63636363636 2449 5.64031162339003e-08 233 2.10950152470549 -2.10628156600432 -1 13.6075533296154 3236 1984 2145 233 3028 3964 4453 3536 381 1702 2449 2450 M16270 GO_DEFENSE_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_FUNGUS.html Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. 20/101 Gene Ontology BP GO:0050832 5.96136186694198e-08 2.09276523367486e-07 3655 2672.27272727273 2449 5.41942002588872e-09 736 4.05942486309765 -4.17324018254038 -1 29.1492205222635 3655 2449 736 2305 1211 4504 3860 3482 1934 1857 3402 2451 M15666 GO_REGULATION_OF_DENDRITE_EXTENSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DENDRITE_EXTENSION.html Any process that modulates the frequency, rate or extent of dendrite extension. 17/29 Gene Ontology BP GO:1903859 6.204341036008e-07 9.40351753763688e-07 3240 2466.18181818182 2450 5.64031162339003e-08 234 2.10950152470549 -2.10628156600432 -1 13.6075533296154 3237 1985 2146 234 3029 3965 4454 3542 382 1704 2450 2452 M14657 GO_CELLULAR_RESPONSE_TO_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. 158/213 Gene Ontology BP GO:0071478 8.8014936388847e-08 2.4552368046601e-07 1745 2477.54545454545 2451 8.00135817364018e-09 1350 1.78564768168226 1.9556982895313 1 12.6250330806871 1745 3611 2909 3716 1595 1656 1350 2132 3095 2993 2451 2453 M16475 GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. 62/90 Gene Ontology BP GO:1902305 2.09245363447223e-07 4.09599779604513e-07 4255 2484.72727272727 2451 1.90223075771702e-08 282 2.14649120655656 -1.79730935631582 -1 14.6842599312141 4251 282 1311 1553 2333 3962 4514 2451 2700 496 3479 2454 M14317 GO_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. 561/765 Gene Ontology BP GO:0005975 1.53101889393792e-08 1.97691467186943e-07 2455 2499.36363636364 2452 1.531018904486e-09 62 1.79880671544624 -1.56979670009111 -1 12.9015942629151 2452 2118 4486 4075 62 1918 2482 2545 2071 2187 3097 2455 M16135 GO_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OSTEOCLAST_DIFFERENTIATION.html The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. 44/50 Gene Ontology BP GO:0030316 1.38653967903986e-07 3.1076922575012e-07 3420 2360.72727272727 2452 1.26049069675081e-08 497 2.28263270391209 -2.04250608794869 -1 15.918210173078 3418 497 1653 1440 2021 2959 3218 2452 3002 2183 3125 2456 M16176 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition. 36/44 Gene Ontology BP GO:1902808 7.24642546877451e-07 1.07380948108942e-06 1275 2116.45454545455 2452 6.58766168693163e-08 733 1.75274841422986 1.99091632054625 1 11.1781272960986 1273 3092 2967 2452 3107 1067 733 1352 2754 3720 764 2457 M10966 GO_CELLULAR_RESPONSE_TO_LITHIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_LITHIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. 19/27 Gene Ontology BP GO:0071285 4.2327367870301e-06 5.08256110194866e-06 2840 2384.54545454545 2453 3.84794993701454e-07 943 2.5576301078105 2.51149420423975 1 14.499569758501 2839 2453 2103 1754 3850 2748 1816 1379 943 3277 3068 2458 M11873 GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_DEHYDROGENASE.html A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). 18/19 Gene Ontology BP GO:0033539 1.83893460588197e-06 2.37748339015527e-06 2040 2626.54545454545 2454 1.67176013001024e-07 1307 0.888457408689258 -0.938224169456241 -1 5.27936883373045 2037 2454 3774 2894 3567 1307 1638 1772 3440 4307 1702 2459 M12589 GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. 19/36 Gene Ontology BP GO:0042088 2.33990629478044e-05 2.58489648376387e-05 1185 2519.72727272727 2454 2.12721016568055e-06 1018 1.48908867641128 -1.70262759743957 -1 7.25943360941797 1183 2843 3111 2454 4190 1629 2029 1018 3478 3607 2175 2460 M16068 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport. 17/30 Gene Ontology BP GO:1901380 3.52743169115745e-07 6.02317051704794e-07 3905 2225.54545454545 2454 3.20675659703475e-08 733 2.89515876992574 -3.02354221152402 -1 19.3221277515754 3901 908 1548 817 2686 3507 3578 2454 733 1322 3027 2461 M10118 GO_ACYLGLYCEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell. 19/41 Gene Ontology BP GO:0055090 2.1003862470902e-05 2.33192488850172e-05 1375 2202.09090909091 2455 1.90946027289751e-06 683 2.2662075301628 -2.38129850818838 -1 11.2163723745795 1374 3174 2824 2800 4169 1738 2455 875 1220 2911 683 2462 M12625 GO_COBALAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COBALAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. 19/42 Gene Ontology BP GO:0009235 1.47036901568997e-06 1.95866791583322e-06 2450 2161.45454545455 2455 1.33669999855579e-07 83 2.35770358799065 -2.9190435088037 -1 14.4110533197295 2449 2456 2650 1170 3463 2455 2987 1260 83 3280 1523 2463 M13129 GO_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction. 23/38 Gene Ontology BP GO:0019098 8.47349156592242e-08 2.42032880639883e-07 2405 2301 2455 7.70317444753304e-09 781 1.73558553495506 1.5293779484275 1 12.2795576143518 2405 781 2455 1586 1555 2757 2955 2747 2426 3100 2544 2464 M10346 GO_LUNG_EPITHELIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_EPITHELIUM_DEVELOPMENT.html The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. 30/43 Gene Ontology BP GO:0060428 7.98928521862004e-08 2.35428398494231e-07 4485 2621.45454545455 2456 7.26298682613672e-09 654 2.16776183748307 1.9320223280595 1 15.393550003416 4481 654 2056 1930 1493 4651 4615 2859 1005 2636 2456 2465 M11593 GO_TRIGLYCERIDE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell. 19/41 Gene Ontology BP GO:0070328 2.1003862470902e-05 2.33192488850172e-05 1375 2222.63636363636 2456 1.90946027289751e-06 684 2.2662075301628 -2.38129850818838 -1 11.2163723745795 1375 3175 2825 2801 4170 1739 2456 1090 1221 2913 684 2466 M13832 GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM.html A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. 232/471 Gene Ontology BP GO:0022412 5.897003323229e-08 2.08467047776528e-07 1455 2254.54545454545 2457 5.36091225572324e-09 1201 1.96915842843462 2.00723117122693 1 14.0851354516872 1455 3863 2457 2541 1201 2065 1675 2573 1659 2641 2670 2467 M10262 GO_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 176/205 Gene Ontology BP GO:0010212 2.52825299566375e-07 4.63878595773795e-07 1210 2073.18181818182 2459 2.29841207837466e-08 1175 1.90861537279956 2.17649409359736 1 12.9330820413103 1210 3608 2910 2459 2495 1175 1186 1376 2592 2520 1274 2468 M10530 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 97/150 Gene Ontology BP GO:0071347 8.89594456032695e-08 2.46385893090484e-07 2825 2255 2459 8.0872226545858e-09 1250 2.05506152118754 2.04942768348415 1 14.5435522168992 2822 1646 1796 1250 1608 2507 2459 2511 2840 2152 3214 2469 M12035 GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_INVOLVED_IN_EMBRYONIC_PLACENTA_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. 26/36 Gene Ontology BP GO:0060706 5.50122985439898e-08 2.05617623085131e-07 3765 2722.63636363636 2460 5.00111817450953e-09 681 2.28525642285023 1.98263599684331 1 16.3790398449291 3762 3439 2268 1755 1120 4025 4280 4317 1842 2460 681 2470 M12488 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. 33/44 Gene Ontology BP GO:1904036 4.65558002116616e-07 7.47753325456891e-07 1390 2341.81818181818 2460 4.2323463694251e-08 1387 2.4531748980449 2.38600054477481 1 16.1063940359645 2535 1844 1387 1389 2861 2646 2460 3284 1994 2035 3325 2471 M15219 GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. 16/22 Gene Ontology BP GO:0010310 3.90395709688715e-06 4.7108693910311e-06 1895 2390.63636363636 2460 3.54905820416141e-07 638 1.63187316449216 -1.772948676997 -1 9.26847100854543 1895 3208 2983 3129 3827 1771 1711 1416 2460 3259 638 2472 M16636 GO_ESTROGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_METABOLIC_PROCESS.html The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 18/50 Gene Ontology BP GO:0008210 3.41010789117997e-08 1.97691467186943e-07 3365 2324.36363636364 2460 3.10009813094391e-09 308 1.98375269442233 2.96788010210978 1 14.2397118728082 3365 2460 2433 1927 552 3930 3273 1014 308 3487 2819 2473 M16961 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. 20/23 Gene Ontology BP GO:0032703 3.18055167145861e-07 5.55105286095158e-07 4310 2849.18181818182 2460 2.89141102842977e-08 826 1.88180453459933 -1.98376696031203 -1 12.5914672404538 4307 826 1959 1954 2626 4623 4268 2460 2384 1859 4075 2474 M10449 GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any negative regulation of signal transduction that takes place in extracellular region. 9/15 Gene Ontology BP GO:1900116 2.56943990674124e-07 4.697683255822e-07 2465 2329.54545454545 2461 2.56944020383225e-08 789 2.62550022456181 3.15469371110155 1 17.8177621069022 2461 1097 4241 2707 2553 3323 4134 806 789 1816 1698 2475 M13657 GO_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INFLAMMATORY_RESPONSE.html The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. 396/732 Gene Ontology BP GO:0006954 1.30349223596488e-22 2.09143081860158e-20 3840 2350.81818181818 2461 1.18499294178625e-23 15 2.58109328336224 2.66378215879063 1 54.7062183041965 3837 1310 15 1094 1634 3602 3781 3442 2461 39 4644 2476 M14282 GO_METANEPHRIC_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. 13/23 Gene Ontology BP GO:0072075 2.43827996308591e-07 4.52906853023502e-07 4420 2542.54545454545 2461 2.21661839392975e-08 353 3.55985621348711 -2.99465269584553 -1 24.2599381542625 4416 1017 1078 976 2461 4572 3298 4253 353 1754 3790 2477 M11901 GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of cell proliferation. 821/1274 Gene Ontology BP GO:0008284 4.10306642977298e-09 6.99324838744824e-08 2770 2220.90909090909 2462 4.1030664373488e-10 132 2.23042740683973 2.48185578289205 1 17.1108152819983 2767 2107 4332 1119 591 2605 2796 2248 2462 132 3271 2478 M13296 GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_REGULATION_OF_SIGNAL_TRANSDUCTION.html Any regulation of signal transduction that takes place in the extracellular region. 9/15 Gene Ontology BP GO:1900115 2.56943990674124e-07 4.697683255822e-07 2465 2352.18181818182 2462 2.56944020383225e-08 790 2.62550022456181 3.15469371110155 1 17.8177621069022 2462 1098 4419 2708 2554 3324 4135 864 790 1821 1699 2479 M10812 GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 187/272 Gene Ontology BP GO:0071216 1.48655108939233e-07 3.25194872392141e-07 3535 2745.63636363636 2463 1.35141017258122e-08 1164 2.03400312653699 -1.97955506109216 -1 14.1287863058762 3532 2175 1322 2030 2075 4353 4292 2463 3579 1164 3217 2480 M11774 GO_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_TRANSPORT.html The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. 26/32 Gene Ontology BP GO:0006862 2.506050470796e-08 1.97691467186943e-07 2975 1984.81818181818 2463 2.27822772667524e-09 265 1.45216006344006 -1.40483715262039 -1 10.39354303613 2973 660 2719 2723 265 2463 2447 2513 1039 1123 2908 2481 M14541 GO_POSITIVE_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_WOUND_HEALING.html Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 52/85 Gene Ontology BP GO:0090303 3.12484102237554e-08 1.97691467186943e-07 2790 2360.36363636364 2463 2.84076460614566e-09 456 2.73680044037874 -2.64277669715137 -1 19.6881485218951 2790 1740 789 2098 456 3331 4253 3820 2945 1279 2463 2482 M15952 GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENOUS_BLOOD_VESSEL_DEVELOPMENT.html The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. 18/23 Gene Ontology BP GO:0060841 2.56597470353405e-05 2.82323960641852e-05 2690 2425.36363636364 2463 2.33273148393052e-06 788 3.48313002244917 3.42254433974882 1 16.988012734471 2687 2463 1085 788 4206 1765 2507 3050 2054 1895 4179 2483 M11317 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. 114/144 Gene Ontology BP GO:0097191 3.71605214868412e-08 1.97691467186943e-07 2465 2389.90909090909 2464 3.37822928313864e-09 653 1.53023918381608 -1.63092517844953 -1 10.958459594568 2464 2641 3388 1665 653 2328 3794 1838 2513 3406 1599 2484 M15756 GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. 35/50 Gene Ontology BP GO:1904837 1.13939114123111e-06 1.57270453282361e-06 1350 2594.36363636364 2464 1.03581066484362e-07 804 1.56395105807026 1.75336464395577 1 9.68217974454382 1346 3950 3580 3741 3337 1692 1911 804 2464 3856 1857 2485 M16590 GO_AZOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AZOLE_TRANSPORT.html The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 11/15 Gene Ontology BP GO:0045117 1.19743199775499e-06 1.63920302605294e-06 1815 2479 2464 1.08857513591134e-07 116 2.44055504029542 -2.48711968356777 -1 15.1251189812426 1814 3249 2343 3318 4613 2464 2779 116 1432 2906 2235 2486 M14600 GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS.html Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. 47/64 Gene Ontology BP GO:0097006 3.00985376239065e-08 1.97691467186943e-07 2465 2313.45454545455 2465 2.73623073051721e-09 413 2.54696944942531 3.03705319319278 1 18.3146869667721 2465 2297 1109 2494 413 3699 4140 2365 2567 1247 2652 2487 M11667 GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 395/602 Gene Ontology BP GO:0045088 1.14006493168542e-06 1.57301525908911e-06 930 2223.27272727273 2467 1.03642320225492e-07 926 1.90752886793072 -1.84768680186508 -1 11.8338862900362 926 3306 2637 2467 3338 1152 1543 1523 3232 2874 1458 2488 M11877 GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 54/72 Gene Ontology BP GO:0009064 5.90285074593892e-07 9.04676038236291e-07 3130 2509.09090909091 2467 5.36622939067423e-08 374 2.18560568595716 -2.31939160638649 -1 14.1421720681072 3126 374 2275 3280 2996 2261 2243 2467 2193 3706 2679 2489 M16171 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane. 18/20 Gene Ontology BP GO:0090005 8.72142891942366e-09 1.41396546209332e-07 1860 2500.36363636364 2468 7.92857177636174e-10 1 1.5757383988591 -1.43768562288288 -1 11.5351735167532 1856 2468 3168 3650 1 2604 2338 2157 4022 3486 1754 2490 M10810 GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. 984/1413 Gene Ontology BP GO:0045937 1.92934500560503e-09 3.43955644102689e-08 2700 2157.90909090909 2469 1.92934500728009e-10 121 2.17073973061811 2.354240094412 1 17.371866824729 2700 1179 4264 713 738 2187 2597 3083 2469 121 3686 2491 M14802 GO_ACETYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. 11/12 Gene Ontology BP GO:0006085 0.0019595450151012 0.00200214381977731 1570 2761.90909090909 2469 0.000178299324169831 1041 1.54306227900093 -1.54306227900093 -1 4.38077995728588 1568 4305 3635 2469 4574 1734 1041 1646 3282 4031 2096 2492 M12940 GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS.html Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. 984/1413 Gene Ontology BP GO:0010562 1.92934500560503e-09 3.43955644102689e-08 2705 2192.27272727273 2470 1.92934500728009e-10 122 2.17073973061811 2.354240094412 1 17.371866824729 2701 1180 4396 714 739 2188 2598 3320 2470 122 3687 2493 M13797 GO_RESPONSE_TO_AUDITORY_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AUDITORY_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. 30/48 Gene Ontology BP GO:0010996 3.15450173767219e-07 5.50972094046122e-07 3620 2014.90909090909 2472 2.86772926362278e-08 174 2.69423489269076 -2.50685169910353 -1 18.0858392422169 3619 629 950 174 2624 3213 3353 2472 589 735 3806 2494 M13261 GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that modulates the frequency, rate, or extent of B cell mediated immunity. 33/54 Gene Ontology BP GO:0002712 7.44695145931404e-07 1.09758204435186e-06 2230 2653.54545454545 2474 6.76995816371987e-08 991 1.62632173526347 -1.71881624732293 -1 10.3469938927816 2226 1852 2955 4497 3125 2474 2398 2123 3838 2710 991 2495 M10375 GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_ALPHA_AMINO_ACID_TRANSMEMBRANE_TRANSPORT.html The directed movement of L-alpha-amino acid across a membrane. 22/33 Gene Ontology BP GO:1902475 1.71830067354714e-07 3.58302323003767e-07 2660 2459.54545454545 2475 1.562091643413e-08 792 2.45841935318037 2.30522525009526 1 16.9887901447859 2658 792 1297 2475 2187 3483 3700 4174 1665 908 3716 2496 M13787 GO_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell. 134/260 Gene Ontology BP GO:0050707 6.6662418515597e-08 2.18361447198576e-07 3600 2352.18181818182 2476 6.06022004868559e-09 303 2.30763826236519 2.06231021252539 1 16.4755237701334 3596 1595 420 1485 1322 2917 2476 4441 2737 303 4582 2497 M13086 GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. 220/306 Gene Ontology BP GO:1904950 2.36806956702365e-08 1.97691467186943e-07 4230 2688.36363636364 2477 2.15279053864858e-09 214 1.95092381707179 -1.89038593749994 -1 14.0021890072721 4230 1451 2219 1554 214 4646 4226 3553 2021 2477 2981 2498 M10711 GO_NITROGEN_CYCLE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_CYCLE_METABOLIC_PROCESS.html A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. 11/30 Gene Ontology BP GO:0071941 2.84324387953324e-06 3.51851430092238e-06 3735 2381 2480 2.58477050372872e-07 149 2.03417865667402 -2.56403268215869 -1 11.8595504335493 2395 2550 2480 1915 3733 3589 2954 866 149 3735 1825 2499 M15080 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes outside the context of DNA replication. 44/63 Gene Ontology BP GO:0006336 4.46961165429013e-06 5.34904913256481e-06 175 1966.81818181818 2480 4.0632915772411e-07 171 1.77229408092095 1.66538422188894 1 9.97020973979462 171 3381 2555 2780 3861 628 364 1127 2728 2480 1560 2500 M11917 GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. 19/26 Gene Ontology BP GO:0051156 1.08339933910825e-06 1.50419797335347e-06 380 1950 2481 9.84908975121113e-08 174 1.48002513627582 -1.34917883790874 -1 9.18743317628326 377 2840 3121 3866 3316 558 174 380 2481 3278 1059 2501 M11245 GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 40/69 Gene Ontology BP GO:0051349 1.57918124358709e-08 1.97691467186943e-07 3335 2515 2482 1.43561932265692e-09 43 2.0447482522178 2.09483293094811 1 14.6810257659961 3335 1794 2128 1964 43 2482 2559 4513 3618 1980 3249 2502 M11454 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 93/113 Gene Ontology BP GO:0008630 4.33388335858742e-07 7.02909696553422e-07 2310 2608.45454545455 2482 3.93989473849063e-08 1547 1.93860561307477 2.34263194371765 1 12.7604449866447 2308 3633 2814 2033 2829 2067 1969 3280 2482 3731 1547 2503 M16465 GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_INDEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures, occurring outside the context of DNA replication. 44/63 Gene Ontology BP GO:0034724 4.46961165429013e-06 5.34904913256481e-06 175 1968.72727272727 2482 4.0632915772411e-07 172 1.77229408092095 1.66538422188894 1 9.97020973979462 172 3382 2556 2781 3862 629 365 1137 2729 2482 1561 2504 M14133 GO_TOXIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_TRANSPORT.html The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 52/59 Gene Ontology BP GO:1901998 1.97267027922594e-06 2.53353248504124e-06 2485 2803.09090909091 2484 1.79333822550826e-07 1294 1.46197335493928 1.71052016468589 1 8.71674559302687 2484 2293 3492 2468 3588 2001 1294 4038 3430 4007 1739 2505 M14380 GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. 221/383 Gene Ontology BP GO:0071383 5.45771897776037e-08 2.05617623085131e-07 1610 2368.54545454545 2484 4.9615628301404e-09 1110 2.11343765651931 1.99021262866412 1 15.1390657677894 1606 3867 1725 3317 1110 1198 2038 3425 2650 2634 2484 2506 M16685 GO_GLYCOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. 17/26 Gene Ontology BP GO:0016137 8.16039573825068e-07 1.18361350904241e-06 675 2151.09090909091 2484 7.41854433196728e-08 674 1.94190622324034 -2.22669777818955 -1 12.3080694119766 674 2484 2537 2846 3173 1360 1419 886 4179 3024 1080 2507 M16798 GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. 75/83 Gene Ontology BP GO:0007266 2.48257309491678e-07 4.58935741384496e-07 2960 2618.63636363636 2485 2.25688488641897e-08 1416 2.27810853406136 2.86597257085998 1 15.4701599925757 2958 2256 1423 2137 2473 3820 4091 3043 1416 2485 2703 2508 M11273 GO_RESPIRATORY_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_SYSTEM_PROCESS.html A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. 14/21 Gene Ontology BP GO:0003016 4.1519432830747e-07 6.82858990575346e-07 3470 2388.36363636364 2486 3.77449460604467e-08 450 2.88276840328575 3.46495887494872 1 19.0693738363325 3469 2505 1460 2311 2792 4245 4444 450 746 2486 1364 2509 M14535 GO_PIRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. 3/15 Gene Ontology BP GO:0034587 5.53826237728922e-08 2.05617623085131e-07 3895 2469.81818181818 2486 5.5382625153148e-09 36 3.0574845621218 -2.5253502726055 -1 21.9520217419729 3893 1133 4499 2486 1233 3402 1341 2394 36 2733 4018 2510 M14160 GO_AMELOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMELOGENESIS.html The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. 15/23 Gene Ontology BP GO:0097186 4.06634256531655e-07 6.72377112879102e-07 2725 2424.72727272727 2487 3.69667574264919e-08 899 2.12442362064199 1.45071686484257 1 14.0386109936442 2723 2487 1695 3277 2776 2234 1282 4334 899 2195 2770 2511 M13315 GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway. 16/20 Gene Ontology BP GO:0035358 1.00742389861773e-07 2.5941026011446e-07 4530 2625.36363636364 2488 9.15839949772436e-09 1088 3.31361460123131 -2.38338259561177 -1 23.439519531132 4527 2488 1488 1770 1741 4281 2695 3898 1088 1924 2979 2512 M14712 GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_TRANSMEMBRANE_TRANSPORT.html The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. 13/16 Gene Ontology BP GO:0072531 3.25139476768407e-06 3.97810671944096e-06 2610 2201.90909090909 2490 2.95581779359288e-07 861 2.39274562060207 -2.17563317968762 -1 13.8323004293704 2607 1030 1798 2490 3774 2688 3075 861 2616 959 2323 2513 M15772 GO_NEPHRON_TUBULE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEPHRON_TUBULE_FORMATION.html The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. 14/25 Gene Ontology BP GO:0072079 4.77626686420125e-06 5.68097385458293e-06 3135 2814.90909090909 2491 4.34207021241209e-07 1722 2.74428514950429 4.0979287791578 1 15.4228276048894 3131 2911 1722 2417 3884 2425 2260 3866 2439 2491 3418 2514 M13037 GO_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTROSOME_CYCLE.html The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. 57/66 Gene Ontology BP GO:0007098 1.91882231078083e-06 2.47252290558382e-06 725 2248.36363636364 2492 1.74438544033115e-07 358 1.39220728611317 1.40823852297871 1 8.31128708543834 724 3054 3784 3187 3579 954 358 1272 2492 3177 2151 2515 M14754 GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION.html Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion. 278/471 Gene Ontology BP GO:0034110 5.50285096012526e-08 2.05617623085131e-07 3020 2354.63636363636 2492 5.00259190706169e-09 355 2.11204989216915 -1.93496735140719 -1 15.1290506113771 3020 2141 673 2492 1121 2389 3654 4227 2967 355 2862 2516 M14342 GO_REGULATION_OF_VASOCONSTRICTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASOCONSTRICTION.html Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. 55/92 Gene Ontology BP GO:0019229 1.01914154794194e-07 2.6098603439058e-07 2940 2425 2493 9.2649235923026e-09 570 2.86529830356592 2.4758253419583 1 20.2448292558413 2938 2287 570 2121 1750 2829 3251 3514 2493 1177 3745 2517 M13599 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate, or extent of mast cell activation. 14/21 Gene Ontology BP GO:0033005 4.40409722561295e-07 7.13518955110622e-07 2320 2443.72727272727 2494 4.00372555204805e-08 1168 2.19429195156887 2.38000771730822 1 14.4429535978301 2316 2524 2168 1776 2835 2782 1168 2654 3675 2489 2494 2518 M13689 GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of protein complex assembly. 418/505 Gene Ontology BP GO:0043254 4.76073828856507e-08 1.98252330758246e-07 2680 2425.27272727273 2494 4.32794399235101e-09 967 1.77192836475204 -1.70256961770317 -1 12.7047716579755 2679 2129 3084 1425 967 2494 3291 3550 2047 3644 1368 2519 M12687 GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_CHEMICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION_OF_TASTE.html The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. 10/60 Gene Ontology BP GO:0050912 6.64032940879146e-08 2.18097241162084e-07 2665 2642.63636363636 2496 6.03666328110783e-09 1316 3.09723278066192 -3.12127213657499 -1 22.1533375411541 2662 2947 1517 3345 1316 2496 2442 4482 2121 2078 3663 2520 M15240 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response. 15/24 Gene Ontology BP GO:0061081 3.3073823516642e-07 5.70901867187186e-07 3040 2265.45454545455 2496 3.00671168080135e-08 1180 2.5193375072142 3.10347423356129 1 16.86248920505 3039 3207 1307 1251 2652 2744 2148 1180 3158 1738 2496 2521 M15018 GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. 54/83 Gene Ontology BP GO:0050810 1.81070962513661e-07 3.71974917693627e-07 2350 2465.90909090909 2497 1.64609979469732e-08 1455 2.58566521332029 -2.02780622325956 -1 17.8285851718232 2350 3057 1455 3110 2221 2563 2799 1907 2497 3167 1999 2522 M16264 GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that activates or increases the frequency, rate or extent of receptor recycling. 16/17 Gene Ontology BP GO:0001921 1.02241438860879e-06 1.4299050646819e-06 2260 2267.18181818182 2497 9.29468057963303e-08 541 1.59063973756276 -0.854413106275048 -1 9.92030220543175 2256 2497 2887 3938 3290 1358 1180 838 2523 3631 541 2523 M12669 GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLMETHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. 16/21 Gene Ontology BP GO:0046500 1.77189332334413e-06 2.30296637807828e-06 2385 2700.09090909091 2498 1.61081340949032e-07 489 1.6525088723722 -2.01232710985999 -1 9.94142184857985 2385 4261 3236 3918 3549 2498 1637 489 1853 4072 1803 2524 M12774 GO_PIGMENT_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. 42/55 Gene Ontology BP GO:0046148 4.28817804672514e-08 1.97691467186943e-07 1685 2290.36363636364 2498 3.89834375482646e-09 486 1.50578368476442 -1.66987844432882 -1 10.7815196355544 1685 2716 3399 2327 814 2533 2703 2498 486 3558 2475 2525 M14138 GO_REGULATION_OF_HISTONE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. 17/19 Gene Ontology BP GO:0033127 0.000152290805847478 0.000159309604228488 1605 2591.18181818182 2498 1.38455771736316e-05 916 1.94390383474348 2.18413702927213 1 7.85430327158508 1604 3776 3336 2969 4435 2129 1479 1414 2498 3947 916 2526 M15563 GO_CAMP_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMP_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). 11/14 Gene Ontology BP GO:0006198 2.09318875216305e-05 2.32559867808374e-05 2170 2817.36363636364 2498 1.90291697096441e-06 1336 1.63397861812031 1.8691123373851 1 8.05774562631383 2167 4057 2932 4138 4168 1568 1336 1441 4339 2347 2498 2527 M13177 GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CONTRACTION.html A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. 16/20 Gene Ontology BP GO:0014829 4.15295438783713e-05 4.48970649781742e-05 3675 2470 2499 3.77548435045509e-06 1074 4.45622392149434 6.176452945808 1 20.7966780838317 3673 2499 1074 2535 4287 4032 2599 1555 1201 2399 1316 2528 M15041 GO_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXPLORATION_BEHAVIOR.html The specific behavior of an organism in response to a novel environment or stimulus. 30/41 Gene Ontology BP GO:0035640 7.30363862998515e-07 1.07934128690109e-06 2500 2516.18181818182 2499 6.63967368606758e-08 1362 2.72318523950445 3.15141466043111 1 17.4231338032274 2499 2378 1425 2816 3115 2864 2585 4354 1945 1362 2335 2529 M15642 GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that modulates the frequency, rate or extent of response to oxidative stress. 71/89 Gene Ontology BP GO:1902882 6.55708825888946e-08 2.17413460714792e-07 1915 2532.36363636364 2499 5.96098950393012e-09 1299 2.02451975944614 2.39921060383077 1 14.4444348082572 1911 3648 2914 2645 1299 2191 1628 2697 2335 4089 2499 2530 M15861 GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an androgen binding to its receptor. 48/55 Gene Ontology BP GO:0030521 3.71495698661179e-06 4.50031108011055e-06 1750 2743.54545454545 2499 3.37723932705949e-07 1351 1.56399870852478 1.8780339489142 1 8.9117832189959 1750 3925 3646 2922 3814 2247 2054 1888 2499 4083 1351 2531 M12607 GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. 22/34 Gene Ontology BP GO:0002292 2.10455529432302e-05 2.33599613179509e-05 1085 2647.63636363636 2500 1.91325038827839e-06 1083 1.61434262450173 -1.85270691579437 -1 7.95617889690303 1083 3152 3134 2455 4171 1943 1784 2187 3736 2979 2500 2532 M13835 GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_ASSOCIATED_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. 72/76 Gene Ontology BP GO:0030433 2.53891388862139e-07 4.6510103636832e-07 535 2776.63636363636 2500 2.30810380147749e-08 534 0.935878029237163 -0.991752309404768 -1 6.28286337335766 534 4402 4121 4294 2500 1266 1108 1871 4322 4428 1697 2533 M16865 GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity. 150/178 Gene Ontology BP GO:0071901 4.05327574072829e-08 1.97691467186943e-07 2940 2414.27272727273 2500 3.68479619582343e-09 753 1.87969810553785 2.14315830530043 1 13.4868581014131 2939 1575 2459 3434 753 2534 3430 3229 2500 2414 1290 2534 M14609 GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_STORAGE.html Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. 26/29 Gene Ontology BP GO:0010888 2.54405162423734e-07 4.65858803918786e-07 2515 2336.36363636364 2501 2.3127744712984e-08 784 2.28659726451165 -1.98910578763976 -1 15.5121801405155 2515 784 1804 3662 2501 2662 3673 1536 4197 1126 1240 2535 M13481 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE.html The directed movement of a protein to a specific location in a membrane. 317/432 Gene Ontology BP GO:0090150 4.95363859166319e-08 2.01774734543894e-07 1570 2668.45454545455 2502 4.50330791200182e-09 1001 1.58388177217295 -1.43856460127565 -1 11.3313961219086 1570 4630 4094 2681 1001 1515 2147 2898 2502 4534 1781 2536 M15088 GO_REVERSE_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REVERSE_CHOLESTEROL_TRANSPORT.html The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. 14/24 Gene Ontology BP GO:0043691 2.19743668539521e-07 4.21984023819394e-07 3385 2357.81818181818 2502 1.99766991352989e-08 997 3.35084703345685 -3.09515674168283 -1 22.9399968206848 3385 2502 997 1714 2382 3054 2932 2800 2988 1144 2038 2537 M10061 GO_L_PHENYLALANINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. 6/12 Gene Ontology BP GO:0006558 2.27775488567647e-07 4.33472126096221e-07 4170 2598.27272727273 2503 2.27775511914403e-08 169 1.69691902251089 -1.91924425055392 -1 11.5399707282773 3719 1120 4222 2503 2479 4166 4170 971 169 2163 2899 2538 M14364 GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 13/13 Gene Ontology BP GO:0009263 1.01289683458421e-06 1.41958101545792e-06 1665 2396.18181818182 2503 9.20815728118146e-08 994 1.65230330561546 1.77518665848007 1 10.3148740330865 1661 994 2449 3290 3282 2547 4166 2503 1069 1336 3061 2539 M11670 GO_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_PRODUCTION.html The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 20/37 Gene Ontology BP GO:0032612 1.7628552701617e-06 2.29225639653245e-06 1550 2663 2504 1.60259698430493e-07 1312 1.75928417952225 -1.73373521598261 -1 10.594928860581 1548 3480 2504 3972 3547 1694 2229 1312 4527 2664 1816 2540 M11823 GO_NAD_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NAD_METABOLIC_PROCESS.html The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 51/75 Gene Ontology BP GO:0019674 2.26720628759321e-07 4.32703480564857e-07 2480 2801.63636363636 2504 2.06109683749073e-08 1725 1.48535539530306 -1.71692882240514 -1 10.0883583254289 2476 3667 3498 4171 2395 1755 2013 2504 3043 3571 1725 2541 M11992 GO_REGULATION_OF_CENTRIOLE_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTRIOLE_REPLICATION.html Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. 14/18 Gene Ontology BP GO:0046599 9.07800122554759e-06 1.04761755214467e-05 1770 2512.18181818182 2504 8.25276244082109e-07 971 0.868046504735691 0.97202462498336 1 4.5520914705171 1766 2504 3574 2598 4007 1527 971 1353 3974 3711 1649 2542 M13543 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 6/12 Gene Ontology BP GO:1902222 2.27775488567647e-07 4.33472126096221e-07 3720 2606.09090909091 2504 2.27775511914403e-08 170 1.69691902251089 -1.91924425055392 -1 11.5399707282773 3720 1121 4433 2504 2480 4167 4171 834 170 2167 2900 2543 M15338 GO_GOLGI_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_LOCALIZATION.html Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. 18/19 Gene Ontology BP GO:0051645 4.15801468225369e-07 6.82858990575346e-07 1290 2224.72727272727 2504 3.78001406192859e-08 409 1.25714166055023 -1.12240675503176 -1 8.25215429985752 1286 4015 3768 3505 2796 952 473 409 2504 4002 762 2544 M13878 GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 549/752 Gene Ontology BP GO:1901699 2.26052342056145e-08 1.97691467186943e-07 2770 2254.63636363636 2505 2.26052344355629e-09 255 1.98203902442313 2.27288611376984 1 14.227313160405 2766 1250 4457 777 255 2505 2675 4002 1825 1147 3142 2545 M14035 GO_MITOTIC_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_CHECKPOINT.html A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. 164/191 Gene Ontology BP GO:0007093 2.36112138883819e-07 4.41848711172251e-07 1365 2581.36363636364 2505 2.14647422022046e-08 840 1.65298923672973 1.804854412302 1 11.2234674609594 1361 4108 3597 3770 2434 840 1454 2505 2916 3460 1950 2546 M16112 GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROSE_4_PHOSPHATE_PHOSPHOENOLPYRUVATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid. 6/12 Gene Ontology BP GO:1902221 2.27775488567647e-07 4.33472126096221e-07 3725 2615.18181818182 2505 2.27775511914403e-08 171 1.69691902251089 -1.91924425055392 -1 11.5399707282773 3721 1122 4594 2505 2481 4168 4172 762 171 2170 2901 2547 M12817 GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. 213/342 Gene Ontology BP GO:0050714 4.42177934511796e-08 1.97691467186943e-07 3095 2224 2506 4.01979948544663e-09 588 2.20679307334895 -2.1566895973895 -1 15.8534493566468 3095 2158 642 775 858 3448 4364 2506 2517 588 3513 2548 M13067 GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 29/33 Gene Ontology BP GO:0010869 2.53980966188675e-06 3.18194247624099e-06 2315 2596.45454545455 2506 2.30892053999768e-07 1600 1.96981337204924 2.47791333994478 1 11.5735440532934 2853 2380 2311 2604 3685 3564 2819 1928 1600 2506 2311 2549 M13827 GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. 11/17 Gene Ontology BP GO:0001956 6.10535161114935e-07 9.28676072137232e-07 3990 2543.54545454545 2506 5.55032118680243e-08 189 1.69843277884494 1.56010291088165 1 10.943819935801 3990 1021 2276 1160 3018 4415 4571 3045 189 1788 2506 2550 M16388 GO_L_PHENYLALANINE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_L_PHENYLALANINE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. 6/12 Gene Ontology BP GO:0006559 2.27775488567647e-07 4.33472126096221e-07 3725 2644.81818181818 2506 2.27775511914403e-08 172 1.69691902251089 -1.91924425055392 -1 11.5399707282773 3722 1123 4620 2506 2482 4169 4173 1053 172 2171 2902 2551 M13437 GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS.html The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. 29/44 Gene Ontology BP GO:0035116 7.92545101770078e-07 1.15457494005516e-06 4185 2607.81818181818 2507 7.20495806620755e-08 582 2.3830439123363 -2.10145667049128 -1 15.1574976474992 4185 1869 1655 1601 3160 4583 4201 582 1488 2507 2855 2552 M13912 GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response. 15/21 Gene Ontology BP GO:0002921 9.49299923041801e-08 2.52405288109343e-07 3525 2755 2507 8.62999967276448e-09 766 2.33969614187015 -2.49217924401205 -1 16.5470901971783 3522 2507 1784 2385 1684 4624 4212 3130 3497 2194 766 2553 M16062 GO_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_NUCLEUS.html A process in which a protein is transported to, or maintained in, a location within the nucleus. 186/234 Gene Ontology BP GO:0034504 2.58320389904331e-07 4.71543654070166e-07 1800 2668.45454545455 2507 2.34836745668993e-08 1088 1.72943741529277 1.85896917941297 1 11.6950415104664 1798 4646 3601 3257 2507 1155 1436 2083 3485 4297 1088 2554 M16162 GO_ACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase (MAPK). 157/224 Gene Ontology BP GO:0000187 6.64040238502829e-08 2.18097241162084e-07 4280 2655.90909090909 2508 6.03672962314535e-09 1270 2.12737898207228 -2.04554573591816 -1 15.1809243223037 4277 1560 1270 1636 1317 4528 3820 3222 2508 1630 3447 2555 M16330 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS.html Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. 24/38 Gene Ontology BP GO:0035774 1.41082664566198e-07 3.13494574129188e-07 3915 2890.54545454545 2508 1.28256976012378e-08 1587 2.02244376488271 -1.11515793774193 -1 14.0825833334879 3913 2408 2508 2161 2038 4288 4217 3561 1587 3217 1898 2556 M11308 GO_REGULATION_OF_HEAT_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEAT_GENERATION.html Any process that modulates the rate or extent of heat generation. 14/18 Gene Ontology BP GO:0031650 1.45300438060991e-07 3.19812175164518e-07 4600 2782 2509 1.32091316052231e-08 986 2.27863682294682 -2.03910135811387 -1 15.8595125068573 4598 986 1205 2126 2059 3527 2509 4592 3808 1139 4053 2557 M11582 GO_RESPONSE_TO_GRAVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_GRAVITY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. 14/20 Gene Ontology BP GO:0009629 2.87767633137233e-07 5.13413649151667e-07 3600 2570.45454545455 2509 2.61606973434768e-08 1141 3.00953871925107 -3.56860063250437 -1 20.3152345213106 3600 2509 1313 2285 2566 3935 3993 1149 2171 1141 3613 2558 M14526 GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY.html Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. 146/175 Gene Ontology BP GO:0090263 7.23466469607546e-08 2.25241234530691e-07 2025 2407.09090909091 2509 6.57696812180567e-09 853 2.23214624809027 2.75236785412589 1 15.9003901416443 2022 3331 1983 1811 1401 3212 3290 2509 853 3438 2628 2559 M10563 GO_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that modulates the frequency, rate or extent of cellular senescence. 40/46 Gene Ontology BP GO:2000772 1.09830517175661e-07 2.70535413667734e-07 2510 2623.18181818182 2510 9.98459296897508e-09 1519 1.86236463833806 2.2290399141201 1 13.087623123896 2510 3682 2947 3002 1820 2241 1519 2362 3257 3933 1582 2560 M16106 GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLFACTORY_BULB_INTERNEURON_DEVELOPMENT.html The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. 13/18 Gene Ontology BP GO:0021891 3.07502867241827e-06 3.77921511166461e-06 3425 2217.63636363636 2510 2.79548451865291e-07 476 3.15669635916555 -1.56132154602885 -1 18.3606434948595 3423 2510 1272 1254 3757 3557 3481 1158 476 961 2545 2561 M15431 GO_STRIATUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATUM_DEVELOPMENT.html The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. 25/37 Gene Ontology BP GO:0021756 8.45017049583144e-07 1.21880481454134e-06 3285 2428.45454545455 2511 7.68197612866577e-08 639 2.46413681427956 2.45401297161258 1 15.6146153696726 3284 2786 1487 2339 3192 3242 2511 2029 3429 639 1775 2562 M13418 GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_DOPAMINERGIC.html The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. 7/19 Gene Ontology BP GO:0001963 2.77266181604495e-07 4.97731305171957e-07 4315 2522.81818181818 2512 2.77266216198941e-08 443 2.10984379061156 -1.00850102708237 -1 14.2389068032384 4313 1113 4426 2353 2604 2904 1878 443 1134 2512 4071 2563 M15084 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 25/35 Gene Ontology BP GO:1902236 2.59997139311767e-07 4.73675289435259e-07 745 2148.36363636364 2512 2.36361063671245e-08 371 1.77382509747742 -1.64338996701915 -1 11.9943589005818 742 3135 2815 2963 2512 1095 371 2272 3786 3004 937 2564 M16676 GO_STABILIZATION_OF_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_STABILIZATION_OF_MEMBRANE_POTENTIAL.html The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 7/16 Gene Ontology BP GO:0030322 2.30560629372906e-06 2.9160060029142e-06 2100 2461.45454545455 2512 2.30560868585173e-07 342 3.80360377137204 -3.31226262835149 -1 22.6087738886098 2098 2080 4643 3025 3684 2512 2950 1169 342 1843 2730 2565 M15274 GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_CIRCULATION.html Any process that activates or increases the frequency, rate or extent of blood circulation. 83/135 Gene Ontology BP GO:1903524 9.8574151277807e-08 2.57032100060153e-07 2635 2243.72727272727 2513 8.96128688132395e-09 482 2.54815777724271 2.46709098449259 1 18.0097803352365 2631 2658 482 2513 1718 2173 3289 3087 3450 559 2121 2566 M15972 GO_MATERNAL_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_PLACENTA_DEVELOPMENT.html Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 33/41 Gene Ontology BP GO:0001893 1.9689807732121e-07 3.93237507536888e-07 2415 2407.63636363636 2513 1.7899826813038e-08 653 1.99199910690248 -2.21343141727086 -1 13.657293414415 2412 3419 2513 3356 2290 2678 2894 653 1919 2997 1353 2567 M12844 GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that activates or increases the activity of a phosphoprotein phosphatase. 20/27 Gene Ontology BP GO:0032516 2.60683350366222e-07 4.74438140955168e-07 585 1888 2514 2.36984892050211e-08 298 1.69590128052418 1.96988559220725 1 11.4612014001419 582 3163 2958 2914 2514 855 298 597 3752 2666 469 2568 M16379 GO_SUBPALLIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUBPALLIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. 27/44 Gene Ontology BP GO:0021544 1.8608673401558e-06 2.40316839682069e-06 2590 2352.36363636364 2515 1.69169901288187e-07 651 2.40342426956608 2.35872842937182 1 14.4623115695698 2586 2770 1585 2361 3571 2515 1858 3188 3472 651 1319 2569 M11766 GO_SPERM_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_MOTILITY.html Any process involved in the controlled movement of a sperm cell. 65/121 Gene Ontology BP GO:0030317 1.58487334026659e-07 3.37501860515352e-07 2500 2512.45454545455 2516 1.44079404949127e-08 1736 2.06239836888415 2.20639244661635 1 14.2916991549103 2497 3044 1736 3619 2135 2527 1857 2050 2516 2750 2906 2570 M14669 GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISMAL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. 294/456 Gene Ontology BP GO:0048871 3.86176666369311e-13 1.34095524523612e-11 2855 1900.45454545455 2518 3.51069696699435e-14 92 2.45823416701944 2.69154055667395 1 28.7319124357006 3134 1363 92 910 311 2518 2985 2855 2854 269 3614 2571 M14860 GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. 47/61 Gene Ontology BP GO:0030857 3.81154175537033e-07 6.39563786070615e-07 4615 2558.45454545455 2518 3.46503855975212e-08 971 2.68445101411793 -2.63380732351842 -1 17.8321489695122 4611 1769 1065 1045 2739 4256 3409 3476 971 2518 2284 2572 M16011 GO_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). 222/281 Gene Ontology BP GO:0046777 6.80283422566843e-08 2.20228333272585e-07 2820 2514.09090909091 2518 6.18439494184135e-09 1343 1.91468596475613 2.14853956260102 1 13.6431183732073 2818 2995 2350 2028 1343 2985 2518 2324 1893 2703 3698 2573 M14825 GO_BODY_FLUID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BODY_FLUID_SECRETION.html The controlled release of a fluid by a cell or tissue in an animal. 75/126 Gene Ontology BP GO:0007589 2.32383553269363e-07 4.39366384950162e-07 2520 2669.81818181818 2519 2.11257798014348e-08 1475 2.36306674645802 -2.38088062950061 -1 16.0995757746976 2519 3360 1475 3887 2416 2807 3322 1549 3280 2261 2492 2574 M16735 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_MEDIATED_BY_A_CHEMICAL_SIGNAL.html The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. 35/73 Gene Ontology BP GO:0003044 4.3962349284493e-08 1.97691467186943e-07 3560 2365.72727272727 2519 3.99657728754432e-09 842 2.53004359648986 -2.24555387819494 -1 18.1922253593299 3560 3412 1107 2519 842 3375 4119 1066 2954 1187 1882 2575 M11802 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 1695/2327 Gene Ontology BP GO:0010628 8.78287617201527e-08 2.4552368046601e-07 1665 2772.27272727273 2520 8.78287651914038e-09 1665 1.88965584733015 2.01278407570196 1 13.366987738344 1665 3580 4325 4160 1702 1862 1776 2371 2520 3689 2845 2576 M15092 GO_PROSTATE_GLAND_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTATE_GLAND_GROWTH.html The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. 14/17 Gene Ontology BP GO:0060736 6.76637010272317e-05 7.23103355258864e-05 2520 2306.09090909091 2520 6.15143474518575e-06 363 3.30640792545865 -3.19234715390814 -1 14.6628468867689 2520 3523 1905 829 4342 2918 3163 931 363 2958 1915 2577 M15205 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. 31/41 Gene Ontology BP GO:0035850 2.64410664597316e-07 4.79961375869106e-07 3295 2072.54545454545 2521 2.4037336034178e-08 92 3.37586220181288 3.57406322781562 1 22.9083957256341 3293 590 609 92 2521 2968 3955 3225 148 1211 4186 2578 M16045 GO_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 1290/1589 Gene Ontology BP GO:0033043 7.68050854966506e-08 2.30287553476591e-07 2230 2592.27272727273 2521 7.68050881512103e-09 1552 1.78600489141843 1.98441231295339 1 12.6812103100992 2227 2098 4589 2521 1552 2554 2835 1595 2028 3691 2825 2579 M12067 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. 13/15 Gene Ontology BP GO:0040037 5.55359886294356e-06 6.57027600032453e-06 3970 2659.81818181818 2522 5.04873898390296e-07 709 2.42280907293849 -2.24616493973166 -1 13.4377386540038 3966 2522 1758 1182 3906 3746 4331 1710 709 2269 3159 2580 M14459 GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HORMONE_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. 74/106 Gene Ontology BP GO:0046888 7.60742419715636e-08 2.29469567498056e-07 2420 2495.45454545455 2522 6.91584041837731e-09 1256 2.26577684177481 1.91611521201275 1 16.1219059311884 2417 3040 1769 2798 1448 1256 1368 3777 2522 2618 4437 2581 M13604 GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. 14/20 Gene Ontology BP GO:0060766 0.00088735651958783 0.000911450305881274 2525 2720.45454545455 2523 8.07013301489369e-05 1442 1.58973465092391 1.54612489971288 1 5.103063124549 1711 2525 3307 2213 4522 2111 2523 1442 3926 3364 2281 2582 M10685 GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. 94/156 Gene Ontology BP GO:0045833 2.3890719873337e-08 1.97691467186943e-07 3275 2551.27272727273 2525 2.17188364843421e-09 223 2.23026920449184 -2.00628704678432 -1 16.0233034116978 3271 2229 1454 1513 223 3649 4376 4641 1648 2525 2535 2583 M10232 GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process. 20/23 Gene Ontology BP GO:0070230 2.66141019256143e-07 4.82225141198923e-07 3510 2620.90909090909 2526 2.41946410410979e-08 1579 2.56559317309417 2.53936341441932 1 17.3771554708548 3509 1971 1579 2618 2526 3102 2122 3380 1970 1849 4204 2584 M11168 GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. 36/51 Gene Ontology BP GO:0034122 6.10816763388877e-07 9.28800784329558e-07 2530 2555.63636363636 2527 5.55288120889585e-08 527 2.05025512662606 -1.97496007741769 -1 13.2340792849216 2527 527 1476 1394 3019 3837 4251 3684 1571 1809 4017 2585 M10718 GO_DENDRITIC_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENDRITIC_CELL_CHEMOTAXIS.html The movement of a dendritic cell in response to an external stimulus. 9/38 Gene Ontology BP GO:0002407 2.26668688404336e-05 2.50579569290894e-05 2530 2602.72727272727 2528 2.26671000478771e-06 317 3.37128993333894 -3.35474356242314 -1 16.6273886697082 2528 3271 4257 1234 4201 2999 2500 1633 317 2425 3265 2586 M13528 GO_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of neuroblast proliferation. 29/44 Gene Ontology BP GO:1902692 1.34089929768179e-06 1.80637070993438e-06 3425 2569.72727272727 2528 1.21900010450925e-07 1805 1.79120006449123 2.14739165223977 1 10.9891809068712 1805 1879 2812 1809 3421 2413 3478 2528 2115 3424 2583 2587 M15318 GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GTPASE_ACTIVITY.html Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. 58/75 Gene Ontology BP GO:0034260 2.69145760254333e-07 4.87289969830121e-07 3270 2591.72727272727 2528 2.44677993801233e-08 1687 1.67011889420854 2.02914069174016 1 11.2643175090642 3268 1719 2843 3108 2528 3439 4054 1738 1687 2329 1796 2588 M13483 GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION.html Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. 359/405 Gene Ontology BP GO:0007264 2.08732329737363e-08 1.97691467186943e-07 3765 2714.81818181818 2529 1.89756665197983e-09 140 1.76915831241164 1.87844662211487 1 12.6870827043214 3761 1335 2529 2071 140 3603 3913 4072 1599 2475 4365 2589 M13638 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS.html The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. 36/43 Gene Ontology BP GO:0002200 2.26016757470356e-06 2.86711006681998e-06 890 2387.27272727273 2529 2.05469990607961e-07 611 1.42495303159085 1.48656879313346 1 8.41054460937726 890 3949 3576 3206 3638 1187 611 1117 2529 3551 2006 2590 M11781 GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VITAMIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 13/28 Gene Ontology BP GO:0030656 1.43752382991796e-07 3.18211150361954e-07 1995 2801.27272727273 2530 1.30683993077149e-08 1341 2.9893974129587 -2.80182329633407 -1 20.8487784390031 1995 3815 1341 3644 2047 2514 1993 4328 3818 2789 2530 2591 M10106 GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYOTUBE_DIFFERENTIATION.html Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. 22/37 Gene Ontology BP GO:0010831 7.89225797806186e-07 1.15009947923338e-06 2125 2506.90909090909 2531 7.17478255393092e-08 1614 1.82455686365485 -2.14370448948952 -1 11.5820222889926 2124 1934 2531 1614 3159 2613 2389 3212 3576 2581 1843 2592 M12199 GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_2_IMMUNE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response. 5/26 Gene Ontology BP GO:0002829 1.17027737691591e-06 1.60675734281196e-06 1305 2763.36363636364 2531 1.17027799321348e-07 1105 1.38086428528551 -1.38086428528551 -1 8.52161355867109 1303 2088 4354 4500 3397 1754 1105 2531 3448 3904 2013 2593 M15033 GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. 28/54 Gene Ontology BP GO:0045581 5.81679524328637e-07 8.94728868330958e-07 2535 2524.63636363636 2531 5.28799707386032e-08 1590 1.9715582458147 -2.4475389914641 -1 12.7562980337319 2531 2387 2178 2610 2986 3179 3561 1590 3352 1679 1718 2594 M10325 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_MONOPOLAR_CELL_POLARITY.html Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. 23/25 Gene Ontology BP GO:0061339 2.70902117972829e-07 4.89517497059252e-07 1915 2580.90909090909 2533 2.46274683028179e-08 1070 2.24788398064093 2.2142861866461 1 15.1954435653973 3249 1913 1914 1162 2533 3180 4058 4502 1070 1270 3539 2595 M14326 GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHING_INVOLVED_IN_LABYRINTHINE_LAYER_MORPHOGENESIS.html The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. 13/16 Gene Ontology BP GO:0060670 8.97412343698181e-07 1.28600543123734e-06 3320 2660.18181818182 2534 8.1582973615098e-08 965 2.26069545538054 -2.02377959646513 -1 14.2592524449876 3318 2914 2144 2148 3215 3861 4356 2534 1534 2273 965 2596 M11797 GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 37/46 Gene Ontology BP GO:0043516 2.71599301303272e-07 4.9039641015294e-07 785 2315.27272727273 2535 2.46908486212146e-08 427 1.9419882329344 2.10487290979787 1 13.1105993021787 783 4179 2857 3991 2535 1200 427 787 3362 3375 1972 2597 M13099 GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 17/22 Gene Ontology BP GO:0009068 1.87375115189804e-07 3.80723323571248e-07 2885 2637.90909090909 2535 1.70341028316945e-08 672 2.1009127262518 1.30790672818856 1 14.4420431837565 2882 2473 2535 2495 2248 2815 4062 1619 672 3018 4198 2598 M14384 GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that increases the amount of sodium excreted in urine over a unit of time. 9/17 Gene Ontology BP GO:0035815 2.18922261191653e-07 4.20580215245567e-07 2040 2652.90909090909 2535 2.18922282758787e-08 870 2.67831570526934 2.60650514270296 1 18.3173114949619 2040 2562 4489 3061 2454 2014 2535 3148 4394 870 1615 2599 M10223 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein. 11/14 Gene Ontology BP GO:0042511 2.70161998124439e-06 3.3647317378828e-06 3735 2660.09090909091 2536 2.45602118078542e-07 374 1.98814420316651 -2.36592636055301 -1 11.630248577062 3732 2536 2407 1438 3707 3903 4261 374 1963 2895 2045 2600 M16326 GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity. 17/22 Gene Ontology BP GO:2000479 0.000337957293028654 0.000350148137266161 2345 2603.45454545455 2536 3.07281109241538e-05 1075 2.1139821614275 -1.83641849938742 -1 7.77110918730144 2344 2886 2903 2027 4480 2055 1357 1075 3273 3702 2536 2601 M10054 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. 60/82 Gene Ontology BP GO:0030858 1.39694338455239e-05 1.58073384443635e-05 3005 2466.90909090909 2538 1.26995659532932e-06 1547 2.33659623218907 -2.12476465447456 -1 11.9940756438107 3001 2682 1547 2538 4088 2175 2631 2063 3067 1597 1747 2602 M11754 GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATION_TRANSMEMBRANE_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. 52/91 Gene Ontology BP GO:1904063 3.89466648592641e-08 1.97691467186943e-07 3780 2369.27272727273 2539 3.54060595897619e-09 363 1.9828518051088 1.87911278850325 1 14.233193775677 3780 363 2031 1239 706 3575 2982 3543 2539 1102 4202 2603 M13813 GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. 11/19 Gene Ontology BP GO:0060575 6.80119368453474e-06 7.9572426990546e-06 4095 2960.90909090909 2539 6.18292246380668e-07 1132 2.17003938065322 -1.91813695013464 -1 11.8291878621893 4092 2539 2085 2344 3949 4036 3753 1973 1132 2340 4327 2604 M15322 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT5_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein. 20/31 Gene Ontology BP GO:0042522 9.59705888576125e-07 1.35977816673103e-06 2380 2653.09090909091 2540 8.72460279298937e-08 1234 2.24132229072428 -2.478454092656 -1 14.077489114068 2377 3473 2330 1447 3250 3344 4375 1234 2540 2256 2558 2605 M16125 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS_BY_HOST.html Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. 134/211 Gene Ontology BP GO:0050691 8.18967239157743e-07 1.18748973630445e-06 1945 2199.90909090909 2540 7.44515949113521e-08 967 2.33942249638869 -1.89571274507207 -1 14.8471488675292 1943 2632 1076 3028 3174 1523 2975 1419 2922 2540 967 2606 M13853 GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. 15/23 Gene Ontology BP GO:0048642 1.82068135105261e-05 2.03449335409409e-05 4010 2772.54545454545 2541 1.65517856260563e-06 491 2.26316754471338 -2.21187919949156 -1 11.3459118174124 3993 962 1978 2533 4143 4008 4010 491 3646 2193 2541 2607 M14821 GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 50/58 Gene Ontology BP GO:0010799 4.60411263527622e-08 1.97760774550163e-07 4640 3009.72727272727 2541 4.18555702875463e-09 926 1.88797905033641 -1.79977282716292 -1 13.5464620565346 4640 2294 2316 2158 926 4068 4638 4122 1162 2541 4242 2608 M12070 GO_POSITIVE_REGULATION_OF_VASODILATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VASODILATION.html Any process that activates or increases the frequency, rate or extent of vasodilation. 27/43 Gene Ontology BP GO:0045909 4.14355799197055e-07 6.81994175332118e-07 4220 2665 2542 3.76687161125741e-08 813 2.68525362087403 -2.51272564318111 -1 17.7566690892718 4219 2392 813 2542 2790 4469 3915 2108 3391 822 1854 2609 M16675 GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 188/214 Gene Ontology BP GO:0035966 2.10071146033937e-08 1.97691467186943e-07 2545 3045.09090909091 2542 1.9097377094531e-09 143 1.23992985130253 -1.23394186598076 -1 8.85801906429338 2542 4648 4126 4471 143 2232 2240 2477 3627 4537 2453 2610 M16821 GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS.html The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. 50/72 Gene Ontology BP GO:0048701 1.79225097366408e-06 2.32552810386474e-06 3460 2598.45454545455 2542 1.62932039430917e-07 1312 2.16167805305935 2.56037679101649 1 13.0295314291311 3459 2295 2002 1781 3555 3382 3165 2971 1312 2542 2119 2611 M11747 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion. 7/14 Gene Ontology BP GO:2000484 1.36856052639819e-05 1.55050210112753e-05 2545 3012.18181818182 2545 1.36856895478186e-06 2084 1.60628432008523 1.4874693660795 1 8.22447148511756 2545 2084 4322 2190 4100 3285 3991 3881 2103 2511 2122 2612 M13568 GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation. 32/43 Gene Ontology BP GO:0048713 2.71890195666415e-07 4.90636225952817e-07 4265 2455.72727272727 2546 2.47172935698514e-08 644 2.584018572309 -1.64973745029626 -1 17.4818228780666 4264 1846 1557 668 2536 2874 2636 3332 644 2546 4110 2613 M13662 GO_NEGATIVE_REGULATION_OF_ANOIKIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ANOIKIS.html Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. 32/35 Gene Ontology BP GO:2000811 2.29373962666619e-06 2.90415523343613e-06 1800 2621.36363636364 2547 2.08522001649371e-07 1389 2.10896526074427 2.11438978831333 1 12.4894108232671 1799 2745 2090 3173 3645 2312 2117 3494 1389 2547 3524 2614 M11915 GO_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. 60/112 Gene Ontology BP GO:0031016 1.05388830952873e-06 1.46818631863389e-06 2290 2547.36363636364 2548 9.5808074034898e-08 856 1.9964343324555 -1.98577427090065 -1 12.4552418153971 2289 3049 2150 856 3302 2548 3956 3197 2585 1804 2285 2615 M15263 GO_OLIGODENDROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGODENDROCYTE_DEVELOPMENT.html The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. 34/53 Gene Ontology BP GO:0014003 2.77570904896986e-07 4.98086162933156e-07 4605 2473.54545454545 2548 2.5233721810702e-08 84 2.9958959378309 4.06240282799254 1 20.2651884637726 4602 580 917 597 2548 4637 4578 2869 84 1585 4212 2616 M15521 GO_REGULATION_OF_RENAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. 23/43 Gene Ontology BP GO:0098801 1.03924108241878e-07 2.63663509078223e-07 2550 2504.54545454545 2548 9.44764665009725e-09 811 2.48990676673633 2.61544464883121 1 17.5657630328892 2548 2810 1212 2558 1767 2441 2733 3940 4311 811 2419 2617 M15567 GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of leukocyte degranulation. 38/56 Gene Ontology BP GO:0043300 1.14059635272165e-06 1.57301525908911e-06 1475 2513.90909090909 2548 1.03690631278868e-07 1015 1.65506584170755 -1.70369709641117 -1 10.2526930622942 1472 3088 3130 2204 3339 1647 2548 1015 3534 3222 2454 2618 M13655 GO_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_SALVAGE.html Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. 13/17 Gene Ontology BP GO:0043174 9.21100271944642e-07 1.31468698323878e-06 2795 2279.45454545455 2549 8.37364234175381e-08 776 1.65125754489301 2.08808814828343 1 10.3676850224466 2795 1015 2678 2549 3229 2941 4035 776 814 2272 1970 2619 M15445 GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_ACYL_CHAIN_REMODELING.html Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. 10/20 Gene Ontology BP GO:0036148 9.69564817915682e-05 0.000102531479494583 1620 2686.18181818182 2549 8.81461409425054e-06 1110 2.67947967298411 -3.16187403770565 -1 11.4226208807344 1617 4065 2549 3676 4385 1995 1110 2088 2828 3652 1583 2620 M10096 GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_RECEPTOR_INTERNALIZATION.html The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle. 12/18 Gene Ontology BP GO:0002031 9.17647550740693e-07 1.3101608019627e-06 1775 2439 2550 8.34225394093819e-08 1316 1.58302673909304 1.61152116405009 1 9.93717257728145 1775 2930 2642 2841 3227 1316 1648 2290 3746 2550 1864 2621 M12682 GO_REGULATION_OF_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_SEGREGATION.html Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. 97/115 Gene Ontology BP GO:0051983 2.86404482384601e-06 3.54048899185852e-06 170 2025.45454545455 2550 2.60368050216071e-07 168 1.70180130347562 1.80426477293021 1 9.89829738193635 168 2651 3642 2949 3735 804 620 1102 2550 2939 1120 2622 M14611 GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. 26/28 Gene Ontology BP GO:0031146 4.8561806241245e-07 7.72251246919858e-07 2215 2438.09090909091 2550 4.41471063277837e-08 1345 1.80097242597343 -1.75286707169593 -1 11.7670589123339 2215 3438 3182 2779 2892 2094 2550 1432 1345 3134 1758 2623 M11263 GO_IMMUNE_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. 664/940 Gene Ontology BP GO:0002520 4.06898164204084e-08 1.97691467186943e-07 2615 2326.90909090909 2551 4.06898171654559e-09 606 2.08247166908688 2.39447537370309 1 14.9539615102459 2613 2113 4290 1707 882 2351 2640 3127 2551 606 2716 2624 M16331 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. 508/624 Gene Ontology BP GO:0045786 8.02894487670013e-08 2.35520479581606e-07 1685 2693.27272727273 2551 8.02894516678794e-09 1020 1.61578296828536 1.81846712677949 1 11.4447841915029 1683 4322 4614 4032 1598 1020 1468 2551 2741 4200 1397 2625 M16751 GO_HISTONE_H3_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_DEACETYLATION.html The modification of histone H3 by the removal of one or more acetyl groups. 21/23 Gene Ontology BP GO:0070932 9.39724870102282e-08 2.51115998606105e-07 2555 2509.72727272727 2551 8.54295372947646e-09 926 1.14959830325992 -1.2196367085346 -1 8.07556384668029 2551 3160 3729 2657 1674 2058 2248 1213 3420 3971 926 2626 M11991 GO_RESPONSE_TO_METHYLMERCURY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_METHYLMERCURY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. 12/14 Gene Ontology BP GO:0051597 2.6697491427143e-08 1.97691467186943e-07 4090 2436.63636363636 2552 2.42704470464755e-09 37 2.41083520336751 -1.97036070074127 -1 17.3297310733379 4086 1038 1958 615 310 3811 3579 4463 37 2552 4354 2627 M15624 GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY.html Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity. 551/689 Gene Ontology BP GO:0071900 5.19411829139149e-08 2.03844518708446e-07 2880 2664.90909090909 2552 5.19411841279638e-09 1166 1.95677957146496 2.1320940618957 1 14.0164457991395 2877 2595 4564 2191 1166 2145 2382 3586 2552 1739 3517 2628 M13245 GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_N_METHYL_D_ASPARTATE_SELECTIVE_GLUTAMATE_RECEPTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. 17/23 Gene Ontology BP GO:2000310 3.99918646242997e-07 6.6529190595948e-07 3465 2063 2553 3.6356247176428e-08 232 3.32729251262403 3.74576039607517 1 22.0679639358824 3464 852 693 575 2761 2888 2553 4357 232 762 3556 2629 M14177 GO_RESPONSE_TO_FATTY_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FATTY_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. 102/179 Gene Ontology BP GO:0070542 4.96089181857327e-08 2.01774734543894e-07 2480 2381.54545454545 2553 4.5099017549445e-09 1003 2.30265011108005 2.42480680316004 1 16.5249275743385 2479 2224 1191 3637 1003 2681 2573 2553 3544 1313 2999 2630 M14280 GO_LYMPHOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_CHEMOTAXIS.html The directed movement of a lymphocyte in response to an external stimulus. 20/56 Gene Ontology BP GO:0048247 5.91260270764579e-06 6.96842461972539e-06 2295 2546 2553 5.37510781645581e-07 892 2.76473149321588 -3.38395924315161 -1 15.2738812746058 2294 2438 1668 1902 3921 2553 3348 892 3106 3055 2829 2631 M15755 GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_UBIQUITIN_PROTEIN_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. 22/24 Gene Ontology BP GO:1904666 3.34778655900526e-06 4.09066461634756e-06 1070 2249.63636363636 2553 3.04344695764889e-07 317 1.83980262191898 1.92495707342075 1 10.5855784173576 1069 3458 3150 3941 3781 719 317 2244 2553 2983 531 2632 M12193 GO_SEXUAL_REPRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEXUAL_REPRODUCTION.html A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. 623/1219 Gene Ontology BP GO:0019953 6.99797238702782e-08 2.2180902940627e-07 1550 2504.09090909091 2556 6.99797260740011e-09 1463 1.95417864495631 1.98210678845115 1 13.9203060751868 1546 3299 4353 3046 1463 1689 1966 2813 2208 2606 2556 2633 M10477 GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of ERBB signaling pathway. 98/115 Gene Ontology BP GO:1901184 2.19110410018258e-08 1.97691467186943e-07 3020 2521.45454545455 2557 1.99191283818638e-09 167 1.58279769381959 -1.51150037238813 -1 11.3387299209346 3017 1641 3324 2407 167 3158 3137 2537 2491 3300 2557 2634 M12562 GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 10/20 Gene Ontology BP GO:0045076 7.59022646565685e-08 2.29469567498056e-07 4060 2797.63636363636 2557 6.90020611593408e-09 1442 3.45756017171397 -3.54108967565109 -1 24.6614082821575 4059 2557 1513 2386 1442 3453 3985 3795 2196 2077 3311 2635 M13342 GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PSEUDOPODIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of the assembly of pseudopodia. 12/24 Gene Ontology BP GO:0031272 3.42294570347176e-06 4.17361050144234e-06 1080 2484.18181818182 2557 3.11177366290111e-07 1078 2.13007364124766 -2.28510435190989 -1 12.2534983062908 1078 3252 2646 3924 3787 1643 1278 1593 3512 2557 2056 2636 M13498 GO_CELLULAR_SODIUM_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_SODIUM_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. 14/21 Gene Ontology BP GO:0006883 3.98517427848709e-06 4.80264592535624e-06 3030 2507.27272727273 2557 3.6228922703826e-07 490 2.61998480362309 2.68071865040088 1 14.9253887158809 3027 2899 1850 2557 3835 1987 490 2073 3444 1532 3886 2637 M13508 GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. 236/273 Gene Ontology BP GO:0045930 1.12584614929285e-07 2.74557763766229e-07 1075 2379.90909090909 2558 1.0234965517344e-08 484 1.64232033453445 1.85372539128505 1 11.5165553203766 1074 3864 3680 3788 1841 484 1047 2558 2756 3752 1335 2638 M11554 GO_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOCYTOSIS_ENGULFMENT.html The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. 30/159 Gene Ontology BP GO:0006911 1.68045387947726e-08 1.97691467186943e-07 4605 2417.18181818182 2560 1.52768535664845e-09 60 2.43301297154278 2.41105770511894 1 17.4901912374775 4605 623 1001 768 60 4608 4344 3565 2560 1093 3362 2639 M13752 GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of chemokine production. 60/101 Gene Ontology BP GO:0032722 2.10486569646253e-07 4.10819634464772e-07 2910 2641.90909090909 2560 1.91351445258826e-08 1352 2.1706885884111 2.09392650067964 1 14.848044937653 2908 3653 1352 2910 2341 2560 2026 2375 3317 1382 4237 2640 M14705 GO_ACTIVATION_OF_MAPKKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKKK_ACTIVITY.html Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK). 12/13 Gene Ontology BP GO:0000185 3.41530440199953e-07 5.85319019613401e-07 3050 2686.54545454545 2563 3.10482266563208e-08 1029 1.29853370966911 0.895525158404475 1 8.62139331533621 3048 1029 3070 2430 2674 2380 1371 4648 2349 2563 3990 2641 M15525 GO_CARDIAC_CHAMBER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_CHAMBER_FORMATION.html The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. 12/19 Gene Ontology BP GO:0003207 2.6761823662861e-07 4.84712983664041e-07 3895 2510.27272727273 2564 2.43289335620857e-08 508 2.78297386633223 3.64394842615968 1 18.8523787009796 3895 1028 1550 1252 2527 3264 3087 3544 508 2564 4394 2642 M12711 GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS.html The process in which the anatomical structures of the eye are generated and organized during embryonic development. 31/43 Gene Ontology BP GO:0048596 3.38289957825137e-07 5.80835119468768e-07 3990 2677.27272727273 2568 3.07536372584884e-08 1403 2.63505219064463 -2.03464906006838 -1 17.620883807502 3986 1847 1403 1942 2668 3225 2568 4181 1437 1772 4421 2643 M16342 GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE_TO_BACTERIUM.html Any process that modulates the frequency, rate or extent of defense response to bacterium. 9/15 Gene Ontology BP GO:1900424 3.83731203280939e-07 6.42960492929855e-07 2380 2955.81818181818 2568 3.83731269543291e-08 1639 2.27264457543205 -2.50759150929185 -1 15.0736279627485 2378 2568 4615 1639 2809 2466 3015 4577 3655 2440 2352 2644 M14795 GO_PHOSPHOLIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_TRANSPORT.html The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. 50/68 Gene Ontology BP GO:0015914 2.50659328314898e-07 4.61908061247217e-07 2360 2886.63636363636 2569 2.27872142612763e-08 2103 2.04368773973745 -1.7493798646044 -1 13.8604355542529 2359 3062 2368 4111 2483 2103 2569 3563 3660 2298 3177 2645 M10585 GO_FOREBRAIN_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_MORPHOGENESIS.html The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). 9/20 Gene Ontology BP GO:0048853 7.4211044174063e-06 8.63907902281499e-06 2610 2685.27272727273 2570 7.42112920027864e-07 1335 2.03144127286947 2.39933373354601 1 10.9881676523674 2609 2570 4249 1643 3985 2435 3135 2319 1335 3005 2253 2646 M11054 GO_BARBED_END_ACTIN_FILAMENT_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_BARBED_END_ACTIN_FILAMENT_CAPPING.html The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. 14/19 Gene Ontology BP GO:0051016 7.63458707881892e-05 8.13272291157153e-05 2755 2353.54545454545 2570 6.94077457476025e-06 310 1.82547220643052 -3.09860470861602 -1 7.94417534189217 2751 3536 2995 2570 4567 2536 741 641 310 3984 1258 2647 M12928 GO_PARENTAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_PARENTAL_BEHAVIOR.html A reproductive behavior in which a parent cares for and rears offspring. 10/16 Gene Ontology BP GO:0060746 9.54936113561271e-07 1.35425715830558e-06 2360 2723 2572 8.68124116420797e-08 1661 2.05756281365335 1.70509136570462 1 12.9179679013994 2357 3268 2510 2572 3247 1954 1661 2688 3816 3647 2233 2648 M13704 GO_NUCLEUS_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_LOCALIZATION.html Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. 27/39 Gene Ontology BP GO:0051647 1.50451868656922e-07 3.26796159230072e-07 4435 2831.09090909091 2572 1.3677443540537e-08 276 2.13277538810237 -1.58936350554141 -1 14.8154694459397 4433 2379 2101 1570 2089 4430 3535 3206 276 2572 4551 2649 M15172 GO_ESTROGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTROGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. 9/23 Gene Ontology BP GO:0006703 3.18369155797837e-07 5.55251902319278e-07 2120 2665.54545454545 2572 3.1836920140936e-08 824 0.829540145482333 -0.893319874117613 -1 5.48724667748221 2116 2572 4539 3450 2681 1686 2098 824 3730 3901 1724 2650 M11186 GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROLOGICAL_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. 12/23 Gene Ontology BP GO:0031645 2.91019417575514e-07 5.17884837557084e-07 1670 2588.27272727273 2573 2.64563141883657e-08 542 2.02365359688287 -2.14812313024025 -1 13.6149583498926 1668 3238 2492 3464 2573 2992 3995 1043 4448 2016 542 2651 M12075 GO_COFACTOR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein. 23/37 Gene Ontology BP GO:0051187 2.79440143780052e-06 3.465445066654e-06 3960 2476.18181818182 2573 2.54036817018777e-07 251 2.22749562802952 -1.40129225518781 -1 13.0132310158611 3959 1910 1823 1881 3724 2573 1760 2578 251 2738 4041 2652 M13927 GO_MATERNAL_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATERNAL_BEHAVIOR.html Female behaviors associated with the care and rearing of offspring. 10/16 Gene Ontology BP GO:0042711 9.54936113561271e-07 1.35425715830558e-06 2360 2722.81818181818 2573 8.68124116420797e-08 1662 2.05756281365335 1.70509136570462 1 12.9179679013994 2358 3269 2511 2573 3248 1955 1662 2674 3817 3650 2234 2653 M10666 GO_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COAGULATION.html Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. 93/144 Gene Ontology BP GO:0050818 2.77271359819783e-13 1.01586113168618e-11 3040 2193.72727272727 2574 2.52064872563471e-14 87 3.16251961648246 3.18630763295699 1 37.4075740729886 3037 1637 87 1679 1824 3083 3282 2574 3334 153 3441 2654 M11379 GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_JUN_KINASE_ACTIVITY.html The initiation of the activity of the inactive enzyme JUN kinase (JNK). 40/58 Gene Ontology BP GO:0007257 3.19521228258068e-08 1.97691467186943e-07 2210 2631.90909090909 2574 2.90473848089724e-09 474 1.74770037570147 -2.31254600810626 -1 12.5318306510309 2207 3083 3029 3956 474 2524 2574 1985 3549 3144 2426 2655 M10946 GO_PEPTIDYL_SERINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_SERINE_MODIFICATION.html The modification of peptidyl-serine. 177/216 Gene Ontology BP GO:0018209 1.21339843336953e-07 2.87033193211408e-07 2325 2679.81818181818 2575 1.10308954572171e-08 1908 1.840369909001 2.21754118423847 1 12.8806603264678 2323 3001 2875 2012 1908 3114 2529 3462 2042 2575 3637 2656 M13880 GO_RETINAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINAL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A. 13/26 Gene Ontology BP GO:0042574 4.67792027179669e-08 1.98236457419581e-07 2595 2336.63636363636 2575 4.2526548829678e-09 945 2.96135085718634 2.11725727718117 1 21.308990274484 2592 2905 1062 3079 945 2575 2484 1554 4131 1753 2623 2657 M12835 GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CLATHRIN_MEDIATED_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis. 25/27 Gene Ontology BP GO:2000369 1.82395439757086e-06 2.36073986422732e-06 3410 2637.45454545455 2576 1.65814173614438e-07 956 1.19860876427504 -1.38126884440794 -1 7.16579395399734 3406 1899 3511 2576 3564 2596 2530 2028 956 3998 1948 2658 M15754 GO_RESPONSE_TO_MERCURY_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MERCURY_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. 13/20 Gene Ontology BP GO:0046689 2.92788126745079e-07 5.20574380490964e-07 2090 2536.09090909091 2576 2.66171059737222e-08 484 2.10513342815467 -1.66844420627753 -1 14.1625901046471 2088 3545 2499 2812 2576 1850 484 2892 3423 3239 2489 2659 M13476 GO_DETOXIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETOXIFICATION.html Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. 61/97 Gene Ontology BP GO:0098754 3.07430677005266e-08 1.97691467186943e-07 3035 2518.09090909091 2577 2.79482437546671e-09 435 2.03458961298643 -2.03747691775576 -1 14.6075261737189 3476 2277 1909 2489 435 3035 3034 3283 2577 1673 3511 2660 M16115 GO_MITOCHONDRION_DISTRIBUTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_DISTRIBUTION.html Any process that establishes the spatial arrangement of mitochondria between and within cells. 14/17 Gene Ontology BP GO:0048311 4.07772797299369e-07 6.73541649213335e-07 2860 2225.63636363636 2577 3.70702611709631e-08 957 1.95990268040914 2.27046455770638 1 12.9410758998858 2859 982 2577 3426 2779 1961 1200 1533 957 3370 2838 2661 M10344 GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes. 18/23 Gene Ontology BP GO:0046337 3.14674414480152e-07 5.50236772106782e-07 720 2010.09090909091 2580 2.86067690444769e-08 96 1.84375625989714 -2.10405365164819 -1 12.3422058117759 719 3763 2580 3902 2621 491 96 1597 2810 3152 380 2662 M13573 GO_RESPONSE_TO_UV http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. 151/182 Gene Ontology BP GO:0009411 2.44812835307183e-07 4.54192233925168e-07 1435 2435 2580 2.2255714777237e-08 883 1.5679142742113 1.61699505998523 1 10.6197562193998 1435 3329 3693 2662 2464 1184 883 1446 3097 4012 2580 2663 M14007 GO_MICROTUBULE_BUNDLE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_BUNDLE_FORMATION.html A process that results in a parallel arrangement of microtubules. 84/140 Gene Ontology BP GO:0001578 2.31388826378912e-07 4.38019613157477e-07 2585 2521.54545454545 2581 2.1035350065058e-08 959 2.03558444451613 2.13784142449117 1 13.8556941016175 2581 2657 1960 4088 2412 2958 3017 959 1708 2373 3024 2664 M16392 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. 6/14 Gene Ontology BP GO:0045086 3.14265879274702e-06 3.85622135091031e-06 3510 2714.54545454545 2582 3.1426632370928e-07 505 2.56867029353835 -2.25972178960931 -1 14.8950891570027 3510 2582 4621 2000 3796 3160 3225 2137 505 2172 2152 2665 M11429 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION.html Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. 22/23 Gene Ontology BP GO:0010569 1.28838006220008e-06 1.74623723548412e-06 1720 2705 2583 1.17125528791931e-07 1099 1.34609998834633 1.5201192881881 1 8.25170688311414 1717 3455 3257 3485 3398 2043 1099 2168 4004 2583 2546 2666 M14635 GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION_INVOLVED_IN_IMMUNE_RESPONSE.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. 23/38 Gene Ontology BP GO:0002367 2.95008036472462e-07 5.23321537821719e-07 2425 2665.45454545455 2583 2.68189160028585e-08 1667 2.19650812798304 -1.85310592653597 -1 14.7768170896422 2424 3145 2355 1667 2583 3551 3920 1734 2761 3102 2078 2667 M12811 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. 5/15 Gene Ontology BP GO:0048934 2.38760242448167e-05 2.63445911337757e-05 1405 2532.09090909091 2584 2.3876280777736e-06 24 3.9003678429371 3.9003678429371 1 19.1630425756618 1405 2584 4389 3407 4211 2490 2952 1342 24 3321 1728 2668 M13764 GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CAMERA_TYPE_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. 13/27 Gene Ontology BP GO:0060219 5.36773427616169e-07 8.35879102643251e-07 3345 2032.45454545455 2584 4.87975962347678e-08 403 4.03756461707435 3.98639237048967 1 26.3709606005635 3344 978 661 444 2952 2584 2781 3931 403 1335 2944 2669 M15873 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus. 79/96 Gene Ontology BP GO:2001022 6.96987006267765e-08 2.21209063933304e-07 2400 2710.36363636364 2584 6.33624571226518e-09 1188 1.69446712398458 1.81852188418675 1 12.0574093811318 2399 3640 3047 4409 1372 1487 1188 2398 2584 3768 3522 2670 M13934 GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm. 175/244 Gene Ontology BP GO:0046824 4.87297638976165e-07 7.74119465399828e-07 1550 2341.72727272727 2585 4.42997951738275e-08 1237 1.91299493864286 2.05414070531587 1 12.5038515372157 1549 3005 2585 1820 2896 1708 1237 3202 2114 3028 2615 2671 M14140 GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT.html The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. 5/15 Gene Ontology BP GO:0048935 2.38760242448167e-05 2.63445911337757e-05 1410 2541.63636363636 2585 2.3876280777736e-06 25 3.9003678429371 3.9003678429371 1 19.1630425756618 1406 2585 4475 3408 4212 2491 2953 1350 25 3324 1729 2672 M16185 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 9/23 Gene Ontology BP GO:0032700 8.98438400240016e-06 1.03732850528953e-05 1595 2508.09090909091 2585 8.98442032622701e-07 782 1.70462330639733 -1.60591792910945 -1 9.05603701674804 1595 3267 4601 2585 4028 1435 968 2213 3103 3012 782 2673 M13383 GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION.html Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. 20/24 Gene Ontology BP GO:0031954 1.6204521928151e-06 2.13173990759645e-06 445 2095.09090909091 2586 1.47313944217406e-07 62 1.81778614165271 1.91907428418513 1 11.0128597488244 445 3172 2954 2586 3503 472 62 1829 3531 3403 1089 2674 M14919 GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. 22/23 Gene Ontology BP GO:0051497 5.92116832218296e-08 2.08691925686504e-07 2520 2802.90909090909 2587 5.3828804377706e-09 808 1.78605948902898 1.77241862247032 1 12.7640336806851 3981 808 2080 3602 1206 3257 2517 2519 4003 2587 4272 2675 M10368 GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. 69/129 Gene Ontology BP GO:0002821 3.00745293495006e-07 5.31069393029322e-07 1285 2275 2589 2.73404849643291e-08 241 1.49834215489008 -1.45132160978004 -1 10.0336967865539 1285 241 2949 2589 2594 1701 3046 3010 3698 2160 1752 2676 M15189 GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. 123/198 Gene Ontology BP GO:0002761 2.18244358127907e-07 4.19624379491385e-07 3885 2825.63636363636 2592 1.9840398161653e-08 1690 2.07949495801694 -2.2377567256134 -1 14.1988381150072 2236 3881 1877 3767 2378 2868 3884 2159 3750 1690 2592 2677 M10626 GO_RESPONSE_TO_IMMOBILIZATION_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_IMMOBILIZATION_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. 17/28 Gene Ontology BP GO:0035902 3.54103252052798e-07 6.03753181312447e-07 3285 2292.63636363636 2593 3.2191209913442e-08 512 4.30336805496314 -4.28723950242876 -1 28.7706451432369 3285 4017 1186 3608 2692 3151 1707 836 512 2593 1632 2678 M14150 GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROLOGICAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The regulation of blood pressure mediated by detection of stimuli and a neurological response. 15/22 Gene Ontology BP GO:0001976 3.00627872927484e-07 5.31063588736365e-07 2710 2636.27272727273 2593 2.73298103643637e-08 1578 2.30903940632494 -3.02418947983763 -1 15.5237619779139 2710 2019 1578 3336 2593 2850 1875 4600 3133 1737 2568 2679 M10989 GO_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 816/1046 Gene Ontology BP GO:0043549 3.94227812251979e-08 1.97691467186943e-07 3145 2494.63636363636 2594 3.94227819245679e-09 830 1.98251987920413 2.18431737988837 1 14.2307922317198 3144 1212 4272 1925 830 2315 2893 3139 2594 1291 3826 2680 M12334 GO_FATTY_ACID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell. 17/37 Gene Ontology BP GO:0055089 6.17043780603528e-07 9.36738894338732e-07 4100 2525.45454545455 2594 5.60949048789644e-08 865 1.81993103234026 -1.48025245417299 -1 11.7274082507819 4100 921 2937 865 3024 4513 2577 1820 1419 2594 3010 2681 M13026 GO_RESPONSE_TO_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 935/1432 Gene Ontology BP GO:0009725 3.0026850817623e-08 1.97691467186943e-07 3205 2335.63636363636 2594 3.00268512233483e-09 49 2.26694170082522 2.3423637915151 1 16.2886355557872 3205 1189 4401 49 518 2594 3314 4240 1726 329 4127 2682 M12512 GO_NITROGEN_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITROGEN_COMPOUND_TRANSPORT.html The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 449/690 Gene Ontology BP GO:0071705 7.87728947211312e-08 2.33849999170963e-07 4075 2737.36363636364 2597 7.16117250378752e-09 1481 1.97279524026222 -1.98396891230337 -1 14.0051158411041 4073 2597 2027 2691 1481 4374 4329 2377 1519 1928 2715 2683 M12332 GO_CARDIAC_ATRIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_ATRIUM_DEVELOPMENT.html The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. 31/55 Gene Ontology BP GO:0003230 3.03012428554172e-07 5.34464302525612e-07 2985 2134.63636363636 2599 2.7546588208088e-08 120 2.51387662610309 2.63089036620179 1 16.903402534908 2984 1854 1888 1046 2599 2856 2870 700 120 3331 3233 2684 M15108 GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURE_B_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. 17/19 Gene Ontology BP GO:0002313 4.14919790786628e-07 6.82680971191719e-07 3630 2384.81818181818 2599 3.77199880945893e-08 54 2.64136022936814 -2.24583551215277 -1 17.4633222063654 3629 867 1246 588 2791 3735 4533 3778 54 2599 2413 2685 M11929 GO_RESPONSE_TO_INTERFERON_ALPHA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERFERON_ALPHA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. 26/37 Gene Ontology BP GO:0035455 5.04212613053431e-07 7.95019074394311e-07 4375 2792.63636363636 2600 4.58375207829747e-08 538 1.95507174858546 -2.14307111234276 -1 12.7569530592238 4373 2391 2600 1858 2917 4300 4336 3576 538 2046 1784 2686 M16654 GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 14/15 Gene Ontology BP GO:0060628 1.67677780396675e-08 1.97691467186943e-07 3350 2635.63636363636 2600 1.5243434697697e-09 56 1.32199345380661 -0.697921613249991 -1 9.45176407161884 3346 2520 3298 3932 56 2422 2600 2367 842 3992 3617 2687 M14202 GO_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOCYTOSIS.html Any process that modulates the frequency, rate or extent of endocytosis. 238/321 Gene Ontology BP GO:0030100 3.58353414828406e-08 1.97691467186943e-07 3275 2070.72727272727 2601 3.25775836968682e-09 491 2.0678505423468 -2.09489642220573 -1 14.8481750136933 3274 1411 929 1122 612 2795 3345 2776 2601 491 3422 2688 M10495 GO_REGULATION_OF_WOUND_HEALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_WOUND_HEALING.html Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. 140/209 Gene Ontology BP GO:0061041 2.21968259481912e-14 1.01256697193072e-12 4140 2306.90909090909 2602 2.0178932680174e-15 67 3.00814409712255 2.89792919215844 1 38.8270998517276 4136 1566 67 894 172 3712 3858 3634 2602 143 4592 2689 M11500 GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYD88_DEPENDENT_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. 48/76 Gene Ontology BP GO:0002755 1.88444944711652e-06 2.43092411351072e-06 1465 2416.81818181818 2603 1.71313732843402e-07 1189 2.13925945631692 -2.16352255483377 -1 12.8487871183312 1462 3383 2108 2606 3575 2045 2603 1189 2862 3326 1426 2690 M11963 GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 18/20 Gene Ontology BP GO:0051974 4.74157744859252e-07 7.57122850662354e-07 1675 2337.72727272727 2604 4.31052588229748e-08 528 2.10490127465324 2.59625426129689 1 13.7914514865657 1674 3509 2792 3228 2880 1630 528 1235 2604 4163 1472 2691 M11759 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus. 35/38 Gene Ontology BP GO:1903846 3.00792028907351e-08 1.97691467186943e-07 4030 2484.90909090909 2605 2.73447302745353e-09 177 2.70710957643593 -2.32214639922981 -1 19.4733297509504 4217 2736 1268 177 411 4026 4369 4029 1529 1967 2605 2692 M12610 GO_PROTEIN_HETEROTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HETEROTETRAMERIZATION.html The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. 18/43 Gene Ontology BP GO:0051290 4.52390871262258e-07 7.29928546119612e-07 2605 2227 2605 4.11264512989473e-08 248 1.94836336314587 1.70176544683675 1 12.7907979820027 2605 871 1849 2317 2848 3016 4011 248 2611 1488 2633 2693 M13146 GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that modulates I-kappaB kinase/NF-kappaB signaling. 308/420 Gene Ontology BP GO:0043122 1.04880988914661e-07 2.64657043934525e-07 1940 2527.81818181818 2605 9.53463581042469e-09 1774 1.78888118545924 -1.6599473759722 -1 12.5851807227644 1936 2605 2840 3425 1774 2041 2965 2995 2393 2659 2173 2694 M13331 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. 35/38 Gene Ontology BP GO:0030511 3.00792028907351e-08 1.97691467186943e-07 4220 2480.09090909091 2606 2.73447302745353e-09 178 2.70710957643593 -2.32214639922981 -1 19.4733297509504 4218 2737 1269 178 412 4027 4370 3965 1530 1969 2606 2695 M10777 GO_PROTEIN_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MATURATION.html Any process leading to the attainment of the full functional capacity of a protein. 272/391 Gene Ontology BP GO:0051604 3.80176570505864e-08 1.97691467186943e-07 4205 2604.36363636364 2607 3.45615070068729e-09 673 2.27561387602689 -1.93903504898119 -1 16.3513803119461 4203 2607 880 1724 673 3438 3698 3794 1976 1065 4590 2696 M11784 GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. 178/213 Gene Ontology BP GO:0032869 4.5974540611813e-08 1.97760774550163e-07 2565 2726.90909090909 2607 4.17950377932425e-09 922 1.51325000464417 -1.35268306015625 -1 10.8352911967208 2561 2178 3573 2559 922 2222 3638 2978 2607 4010 2748 2697 M11008 GO_LYMPHOCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_HOMEOSTASIS.html The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. 53/71 Gene Ontology BP GO:0002260 7.14516150662403e-08 2.23814099129341e-07 3515 2293.81818181818 2608 6.49560158062239e-09 377 1.86366323406269 2.12231473542539 1 13.2624335126716 3514 377 2628 673 1393 3643 2608 4355 969 2350 2722 2698 M11116 GO_T_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_PROLIFERATION.html The expansion of a T cell population by cell division. Follows T cell activation. 40/59 Gene Ontology BP GO:0042098 2.64900456358162e-08 1.97691467186943e-07 4555 2929.63636363636 2608 2.40818599588919e-09 303 2.15633512573021 1.83921513246124 1 15.488376979072 4552 2328 2211 1053 303 4617 4562 4366 1425 2608 4201 2699 M15710 GO_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYLATION.html The covalent attachment and further modification of carbohydrate residues to a substrate molecule. 226/292 Gene Ontology BP GO:0070085 1.39393891843498e-08 1.97691467186943e-07 3555 2603.45454545455 2608 1.26721720660645e-09 26 1.96728280699679 -1.76972135216315 -1 14.1205492583028 3554 2154 2231 3267 26 2608 2846 3396 1873 2498 4185 2700 M16143 GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TUMOR_NECROSIS_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. 257/339 Gene Ontology BP GO:0034612 5.16341557657899e-08 2.03777546037507e-07 2950 2369.45454545455 2608 4.6940142706952e-09 828 2.23950528595993 -1.84029794650226 -1 16.0583008300856 2949 2608 1125 828 1044 2759 3681 3785 1894 2313 3078 2701 M16030 GO_MATING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATING_BEHAVIOR.html The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. 15/27 Gene Ontology BP GO:0007617 9.17057536628325e-08 2.49206886189644e-07 2470 2397.90909090909 2609 8.33688704413957e-09 929 1.53950926106782 1.41225095589578 1 10.8584310341756 2468 929 2609 1949 1643 3087 2943 3369 3562 2700 1118 2702 M16258 GO_REGULATION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOTIC_CELL_CYCLE.html Any process that modulates the rate or extent of progress through the mitotic cell cycle. 564/683 Gene Ontology BP GO:0007346 1.39426605297995e-07 3.11452674737746e-07 1985 2948.27272727273 2609 1.39426614045896e-08 1985 1.63186185201619 1.89450374700071 1 11.3460583591641 1985 3854 4608 3573 2100 2056 2270 2842 2609 4018 2516 2703 M16592 GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_REPRODUCTIVE_BEHAVIOR.html The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species. 15/27 Gene Ontology BP GO:0044705 9.17057536628325e-08 2.49206886189644e-07 2470 2427.18181818182 2610 8.33688704413957e-09 930 1.53950926106782 1.41225095589578 1 10.8584310341756 2469 930 2610 1950 1644 3088 2944 3681 3563 2701 1119 2704 M15474 GO_REGULATION_OF_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of DNA replication. 174/211 Gene Ontology BP GO:0006275 3.10616520094816e-07 5.44778992838741e-07 630 2409.63636363636 2613 2.82378694500511e-08 338 1.61577909829189 1.62509998066123 1 10.8096791863672 630 3873 3763 3238 2613 1069 338 2023 2705 3646 2608 2705 M16926 GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 40/56 Gene Ontology BP GO:0002312 9.87309600466436e-07 1.38958002751674e-06 3500 2458.81818181818 2613 8.97554585044224e-08 447 2.14657843032479 2.16378370819129 1 13.4558204931403 3500 2315 1937 645 3268 2632 1590 3693 447 2613 4407 2706 M11444 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. 198/266 Gene Ontology BP GO:0048002 8.82016501059082e-08 2.45879617590125e-07 1825 2484.36363636364 2614 8.01833214927808e-09 1588 1.65562818479167 -1.59662629559262 -1 11.6963993313713 1821 2614 3546 3140 1596 1818 1588 3260 2875 2945 2125 2707 M15423 GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT.html The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. 204/230 Gene Ontology BP GO:0006888 2.37935540225473e-08 1.97691467186943e-07 2260 2587.27272727273 2614 2.16305038908005e-09 217 1.89091145643165 -1.49607333112428 -1 13.5679887233384 2258 3319 3455 2614 217 2137 1968 4308 666 4452 3066 2708 M15717 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. 95/166 Gene Ontology BP GO:0045638 6.68907569455821e-07 1.00303800215209e-06 2090 2827.18181818182 2614 6.08097975305922e-08 1501 1.89217866057001 -2.0191759747052 -1 12.1368047413822 2089 3629 2300 4162 3067 2606 3463 1501 3592 2614 2076 2709 M14554 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition. 170/194 Gene Ontology BP GO:1901988 3.12707901703414e-07 5.47621327296193e-07 990 2378.90909090909 2616 2.8427995104701e-08 768 1.68115285867057 1.84513886705083 1 11.2475098237405 987 3875 3539 3232 2616 768 1080 1833 2839 3775 1624 2710 M11687 GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 30/47 Gene Ontology BP GO:0048147 1.04751420179829e-07 2.64657043934525e-07 3130 2560.36363636364 2617 9.52285683340849e-09 1669 1.81314486995337 2.05483409774856 1 12.7574152027982 3127 2758 2672 2617 1772 2539 3121 2307 1669 3726 1856 2711 M13712 GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT.html A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. 117/132 Gene Ontology BP GO:0044774 3.12880446156084e-07 5.47717349873686e-07 1160 2642.18181818182 2617 2.8443680968495e-08 938 1.616620439322 1.83641787070493 1 10.8112908177526 1159 4120 3650 4216 2617 938 1191 2439 3035 3938 1761 2712 M12575 GO_REGULATION_OF_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_SILENCING.html Any process that affects the rate, extent or location of chromatin silencing. 26/33 Gene Ontology BP GO:0031935 0.00013402404535756 0.000140580226115584 1360 2721.18181818182 2619 1.21847464365082e-05 781 1.37347303899834 1.6410165802968 1 5.59681627320757 1358 3729 3626 2619 4512 2298 2134 781 3473 4043 1360 2713 M13434 GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. 22/26 Gene Ontology BP GO:0001836 4.63180102397824e-06 5.51901924828956e-06 790 2139.27272727273 2620 4.21073706875871e-07 555 1.68012486062498 -1.80484924494206 -1 9.42118777076965 787 3464 3038 2620 3879 818 556 734 3790 3291 555 2714 M14179 GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_INVOLVED_IN_GAMETE_GENERATION.html The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. 8/21 Gene Ontology BP GO:0043046 9.78202590529597e-08 2.56809599576163e-07 2785 2529.45454545455 2620 9.78202633589212e-09 414 1.45830053288878 1.71056868249268 1 10.2591450663756 2784 2575 4478 2418 1801 2655 2672 1295 414 4112 2620 2715 M15340 GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. 230/336 Gene Ontology BP GO:0002218 3.02344520435668e-06 3.72073275214801e-06 1060 2516.63636363636 2620 2.74859032678644e-07 963 1.98690734454881 -2.1317929327892 -1 11.5292825953178 1057 3866 2756 2648 3752 1926 2235 963 2620 3943 1917 2716 M14329 GO_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_RESPONSE.html Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. 824/1745 Gene Ontology BP GO:0006955 1.58816855319939e-12 4.92649885202452e-11 2175 2451.63636363636 2622 1.58816855320053e-13 69 2.28148924992714 -2.20421855087967 -1 25.2665014204109 2172 2106 4487 1822 1694 2680 3468 3159 2689 69 2622 2717 M11357 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. 30/69 Gene Ontology BP GO:0002716 2.73930532032787e-06 3.40437704473439e-06 1320 2689 2623 2.490280664681e-07 1319 1.55434540527114 -1.23969917715652 -1 9.05940091045772 1319 2358 2623 2870 3713 1589 2844 3049 4402 2290 2522 2718 M12737 GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH_IN_RESPONSE_TO_OXIDATIVE_STRESS.html Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. 31/57 Gene Ontology BP GO:0036473 6.84429434817805e-07 1.02268791271909e-06 2625 2619.72727272727 2623 6.22208770678936e-08 1278 1.94866375464247 2.93611361918356 1 12.484767561665 2623 2369 2659 2612 3078 3515 3186 2093 1278 3332 2072 2719 M14714 GO_ENERGY_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_HOMEOSTASIS.html Any process involved in the balance between food intake (energy input) and energy expenditure. 19/20 Gene Ontology BP GO:0097009 2.4890518125399e-06 3.12508313107074e-06 1985 2617.18181818182 2623 2.26277693511426e-07 1183 1.45550202291225 1.44960576686445 1 8.53450369162791 1982 2466 2788 2623 3675 2166 1183 1878 4097 2916 3015 2720 M16076 GO_POSITIVE_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE.html Any process that activates or increases the rate or extent of progression through the cell cycle. 394/497 Gene Ontology BP GO:0045787 3.15228095332038e-07 5.50790960413058e-07 1440 2499.09090909091 2623 2.86571036817875e-08 1307 1.71809315565194 1.84630679243133 1 11.4924911390287 1436 3593 3450 2663 2623 1413 1307 2475 2780 3660 2090 2721 M16153 GO_GLYCEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCEROL_TRANSPORT.html The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. 5/11 Gene Ontology BP GO:0015793 2.54619183508086e-06 3.18822136938408e-06 3400 2428.63636363636 2623 2.54619475247735e-07 1029 4.67413819349181 -4.03904258897507 -1 27.6136260941152 3397 1129 4598 1304 3725 3093 1959 2745 1113 2623 1029 2722 M15613 GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT.html The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. 19/21 Gene Ontology BP GO:0060742 2.69546456491746e-06 3.35976335937877e-06 3450 2484.27272727273 2624 2.4504253340331e-07 318 2.99107730117691 3.35944873924628 1 17.5563324693207 3447 3477 1659 318 3704 2624 2052 3099 1018 3613 2316 2723 M15795 GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY.html Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. 30/69 Gene Ontology BP GO:0045953 2.73930532032787e-06 3.40437704473439e-06 1320 2691.63636363636 2624 2.490280664681e-07 1320 1.55434540527114 -1.23969917715652 -1 9.05940091045772 1320 2359 2624 2871 3714 1590 2845 3066 4403 2293 2523 2724 M10892 GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. 55/70 Gene Ontology BP GO:0032272 3.16503929031894e-07 5.52605171401652e-07 3555 2713.54545454545 2625 2.87730885968976e-08 130 2.25060847079959 2.37843327965085 1 15.0861228111857 3551 1724 1693 984 2625 3729 4333 4149 130 2533 4398 2725 M13000 GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAS_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. 185/204 Gene Ontology BP GO:0007265 2.24309025537481e-08 1.97691467186943e-07 2955 2513.09090909091 2625 2.03917298022277e-09 184 1.69994551594874 2.03468952585802 1 12.1863156030862 2955 2172 2625 2587 184 3428 3167 2387 2131 2853 3155 2726 M11887 GO_PHAGOLYSOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHAGOLYSOSOME_ASSEMBLY.html The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. 15/19 Gene Ontology BP GO:0001845 7.59054438513803e-08 2.29469567498056e-07 4565 2755.63636363636 2626 6.90049513366417e-09 374 1.96938719745348 2.23955590268887 1 13.9981809210272 4564 2002 2385 1196 1443 4549 3831 2626 374 3117 4225 2727 M15358 GO_RESPONSE_TO_X_RAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_X_RAY.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). 35/37 Gene Ontology BP GO:0010165 2.10607895482201e-06 2.69235253896063e-06 845 2046.63636363636 2626 1.9146190645384e-07 142 2.01506287386576 2.13790598191847 1 11.9998018489417 844 3420 2793 3220 3607 982 142 671 3310 2626 898 2728 M15635 GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine. 18/22 Gene Ontology BP GO:0000097 5.69417788266862e-08 2.0634742747708e-07 2630 2707.36363636364 2626 5.17652548186266e-09 237 1.85806156236065 1.64839051637074 1 13.2929932899206 2626 1963 2588 2730 1164 4011 4524 4380 237 2327 3231 2729 M16917 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. 34/64 Gene Ontology BP GO:0045620 9.21973193601467e-07 1.31552936823908e-06 2655 2601.36363636364 2627 8.38157799982767e-08 1802 1.9800235688082 -2.44198252298179 -1 12.4538185094251 2652 2355 2170 2627 3230 2914 3423 1930 3640 1872 1802 2730 M12216 GO_EMBRYONIC_PLACENTA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_PLACENTA_DEVELOPMENT.html The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. 90/114 Gene Ontology BP GO:0001892 2.09812819853836e-08 1.97691467186943e-07 4310 2572.81818181818 2629 1.90738928958917e-09 142 2.27957289930815 -2.57838342260397 -1 16.3800245614722 4309 3031 1906 1232 142 4626 4025 2820 1439 2629 2142 2731 M13444 GO_MALE_MEIOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS.html A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. 35/155 Gene Ontology BP GO:0007140 3.20541597501557e-07 5.58409786295704e-07 610 2268.54545454545 2629 2.91401494731554e-08 257 1.95296901257807 1.74186182726371 1 13.0664846908259 608 3423 2724 3917 2629 542 257 2481 3626 3195 1552 2732 M12058 GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epithelial cell differentiation. 133/174 Gene Ontology BP GO:0030856 5.87757664300381e-07 9.01693508733819e-07 4170 2600.09090909091 2630 5.34325292115719e-08 567 2.54719425022665 2.50021707495433 1 16.5045191567347 4169 2630 567 1330 2993 3954 3944 2450 1997 944 3623 2733 M14074 GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. 285/421 Gene Ontology BP GO:0045089 1.01714016693839e-06 1.4246698364733e-06 675 2302 2630 9.24673306545141e-08 673 1.9482167579631 -1.95584007868553 -1 12.1791674684323 673 3860 2630 3212 3285 1385 1605 786 3082 3301 1503 2734 M10907 GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION.html Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. 58/68 Gene Ontology BP GO:0048146 2.05874059049362e-08 1.97691467186943e-07 1610 2481.72727272727 2631 1.8715823725083e-09 134 2.20514287162825 2.24554868014656 1 15.8415098487183 3291 2278 1608 1606 134 3442 2904 3149 2631 1861 4395 2735 M13389 GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 24/54 Gene Ontology BP GO:0030813 3.33039334509551e-07 5.74363240723847e-07 1945 2384.09090909091 2631 3.02763077205055e-08 165 2.020654296686 2.34257084040027 1 13.4965793206048 1945 3447 2329 2631 2655 1880 165 2810 2933 2109 3321 2736 M13922 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). 202/264 Gene Ontology BP GO:0097193 1.67250447271262e-07 3.51339201423559e-07 2585 2833.72727272727 2631 1.52045872714666e-08 2170 1.80124564965895 2.1319146172984 1 12.4337581266632 2584 3868 3205 2985 2170 2262 2526 2631 2347 3778 2815 2737 M16527 GO_RESPONSE_TO_REDOX_STATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_REDOX_STATE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. 36/54 Gene Ontology BP GO:0051775 2.7438131119212e-07 4.94268773123087e-07 2115 2682.90909090909 2632 2.49437586738753e-08 1433 2.05240581024454 2.23199431228297 1 13.8549060653525 2111 3097 2373 2632 2540 1609 1433 4440 2723 3286 3268 2738 M12116 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that modulates the activity of the enzyme nitric-oxide synthase. 57/73 Gene Ontology BP GO:0050999 5.06061240498254e-08 2.02998167617902e-07 4320 2836.90909090909 2633 4.60055683762791e-09 1020 2.1441865622118 2.11594506838567 1 15.3738583745688 4319 1736 2119 2633 1020 4315 4378 2777 2293 2228 3388 2739 M15655 GO_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_LOCALIZATION.html Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. 47/54 Gene Ontology BP GO:0051646 3.2133440719345e-07 5.59150709301094e-07 4625 2821.81818181818 2633 2.92122231025378e-08 715 2.04839831421989 -1.28990127398268 -1 13.7092148655774 4622 2298 2558 1621 2633 3998 3038 2442 715 3035 4080 2740 M10630 GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. 20/23 Gene Ontology BP GO:0045618 7.59988787844333e-05 8.09761353295096e-05 1935 2416.54545454545 2634 6.90922766259013e-06 640 1.49624317048452 -1.5731231241356 -1 6.49405762047359 1933 3166 3225 2634 4359 1691 1512 640 2838 3049 1535 2741 M11085 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 458/605 Gene Ontology BP GO:1903829 1.05494868296803e-07 2.64761392764306e-07 2515 2823.36363636364 2634 9.59044303231958e-09 1452 1.82109696472656 1.91025888740301 1 12.813526253394 2511 3302 3255 1452 1783 2634 2562 3987 2157 3849 3565 2742 M11570 GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. 20/32 Gene Ontology BP GO:0002714 5.3045731195299e-07 8.27723473728113e-07 2565 2768.18181818182 2634 4.8223403623208e-08 1969 1.76918154180091 -1.82537263280399 -1 11.4998270846881 3085 1969 2634 2561 2944 3365 2539 3364 3177 2247 2565 2743 M11696 GO_REGULATION_OF_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LEUKOCYTE_MIGRATION.html Any process that modulates the frequency, rate, or extent of leukocyte migration. 130/208 Gene Ontology BP GO:0002685 3.67201068495881e-08 1.97691467186943e-07 2930 2112.90909090909 2634 3.33819158749835e-09 183 2.64570381504511 2.55666133481397 1 19.0290479605549 2929 1597 282 1467 642 3029 3675 3243 2634 183 3561 2744 M12670 GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_EPSILON_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 133/262 Gene Ontology BP GO:0038095 3.11478651608936e-05 3.39735153759114e-05 1600 3114.18181818182 2634 2.83166419680582e-06 1599 1.32867718510832 -1.27043767032799 -1 6.29502451146284 1599 4116 4103 2472 4245 2255 2365 2634 3639 4481 2347 2745 M11366 GO_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRACELLULAR_MATRIX_ASSEMBLY.html The aggregation, arrangement and bonding together of the extracellular matrix. 21/22 Gene Ontology BP GO:0085029 2.94179030440048e-05 3.21846938311202e-05 1315 2512.27272727273 2635 2.6743905837203e-06 1314 3.21634397182536 3.49402303799483 1 15.4806584317321 1314 3486 1694 2825 4232 1945 1736 1552 2635 3181 3035 2746 M14225 GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. 20/32 Gene Ontology BP GO:0002891 5.3045731195299e-07 8.27723473728113e-07 3090 2775.81818181818 2635 4.8223403623208e-08 1970 1.76918154180091 -1.82537263280399 -1 11.4998270846881 3086 1970 2635 2562 2945 3366 2540 3432 3178 2254 2566 2747 M10079 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. 46/56 Gene Ontology BP GO:1903573 3.22448720890314e-07 5.60251642383357e-07 740 2249.54545454545 2636 2.93135243773507e-08 409 1.42126737205364 -1.50731936406611 -1 9.47611044389603 738 3672 3425 2959 2636 703 409 2061 3832 3771 539 2748 M10701 GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that modulates the activity of a monooxygenase. 66/91 Gene Ontology BP GO:0032768 5.84417215282217e-08 2.0762333639785e-07 4250 2779.90909090909 2638 5.31288391642656e-09 1193 2.1388826054291 2.26663509377748 1 15.3129641386384 4250 1711 1975 2638 1193 4178 4036 2846 2068 2384 3300 2749 M15372 GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle phase transition. 376/442 Gene Ontology BP GO:1901987 1.80861305896952e-07 3.71872583446096e-07 1745 2849.63636363636 2638 1.64419382514095e-08 1742 1.61291637928209 1.77295099075709 1 11.0789823423468 1742 3857 3990 2471 2219 2163 2532 2904 2638 4149 2681 2750 M16677 GO_ERK1_AND_ERK2_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERK1_AND_ERK2_CASCADE.html An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 22/29 Gene Ontology BP GO:0070371 2.52203298448551e-07 4.63176235654383e-07 4500 2922.90909090909 2638 2.29275752146003e-08 1454 2.20457290898717 2.23899119934767 1 14.9576405652463 4496 2436 2043 1651 2491 4434 3742 2666 4101 1454 2638 2751 M11032 GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 14/16 Gene Ontology BP GO:0071545 4.64919448522751e-07 7.46985564218357e-07 2640 2189.81818181818 2640 4.22654133429839e-08 336 1.04110075432354 -1.24703777270431 -1 6.77077953774859 2640 976 3232 2128 2860 2880 3494 849 336 3983 710 2752 M11735 GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. 13/17 Gene Ontology BP GO:0060389 4.33140468162366e-07 7.02909696553422e-07 1945 2322.72727272727 2640 3.93764139490877e-08 404 1.81700938586424 2.21074388062339 1 11.9529706820606 1941 3229 2484 1054 2828 2772 3732 2640 404 2788 1678 2753 M12961 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. 37/47 Gene Ontology BP GO:1902235 2.98432578091038e-07 5.28188203064891e-07 970 2378.36363636364 2641 2.71302380521613e-08 970 1.68794301202408 -1.71493899412832 -1 11.3219803577549 970 3096 3079 2641 2588 1474 1495 2702 3770 3376 971 2754 M15580 GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine. 42/53 Gene Ontology BP GO:0000096 6.29279717987788e-08 2.12948256567067e-07 2870 2691.27272727273 2641 5.72072487261335e-09 499 1.85987811190907 1.98583155572894 1 13.2786508143517 2866 499 2641 2500 1267 4070 4653 4460 856 2526 3266 2755 M10868 GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). 20/20 Gene Ontology BP GO:0090153 7.69732422895661e-07 1.12557038457998e-06 2645 2546.09090909091 2642 6.99756992916838e-08 970 1.86772567995085 -1.5335516152172 -1 11.8776001229528 2642 3465 3006 3523 3147 2076 2354 970 2123 3396 1305 2756 M11183 GO_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEFENSE_RESPONSE.html Any process that modulates the frequency, rate or extent of a defense response. 740/1123 Gene Ontology BP GO:0031347 1.35072895997133e-07 3.05242440541359e-07 1900 2578.63636363636 2642 1.35072904207242e-08 1249 2.11068365087742 -1.97150469926404 -1 14.7283354738214 1899 2976 4284 3037 2074 1942 2642 2975 3083 1249 2204 2757 M12740 GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 23/55 Gene Ontology BP GO:0032689 7.15443471130526e-07 1.06254659150027e-06 4325 3059.81818181818 2642 6.50403367085435e-08 1622 1.91476534929245 -2.15390677181132 -1 12.2313051215284 4323 2421 2053 1622 3099 4580 4203 2527 2642 2361 3827 2758 M16885 GO_LACTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LACTATION.html The secretion of milk by the mammary gland. 50/88 Gene Ontology BP GO:0007595 2.39796027133918e-07 4.47202771244136e-07 3570 2713.45454545455 2642 2.17996412064778e-08 1825 2.34121014341684 -2.46431668183548 -1 15.9302214495177 3568 3378 1825 2428 2448 3263 2778 2424 2795 2299 2642 2759 M11494 GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of membrane lipid metabolic process. 20/20 Gene Ontology BP GO:1905038 7.69732422895661e-07 1.12557038457998e-06 2645 2532.18181818182 2643 6.99756992916838e-08 807 1.86772567995085 -1.5335516152172 -1 11.8776001229528 2643 3466 3007 3524 3148 2077 2355 807 2124 3397 1306 2760 M12045 GO_LIPID_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. 105/179 Gene Ontology BP GO:0055088 7.17982781526497e-08 2.23912458608766e-07 3310 2338.54545454545 2643 6.52711640871167e-09 293 2.21654139660903 -2.0281736290275 -1 15.794587437438 2770 2643 1852 3307 1399 1907 2974 2885 3308 2386 293 2761 M15319 GO_PROTEIN_HOMOTRIMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTRIMERIZATION.html The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. 16/23 Gene Ontology BP GO:0070207 1.58248661690711e-08 1.97691467186943e-07 3315 2223.45454545455 2643 1.43862420753648e-09 45 1.59414117900741 -1.85271393105888 -1 11.4208020880151 3311 915 2643 2304 45 3799 3856 928 313 3261 3083 2762 M10447 GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. 72/77 Gene Ontology BP GO:2000573 9.37608332228391e-07 1.33293356854834e-06 1165 2471 2644 8.52371574385278e-08 743 1.69578646792606 1.7548030256127 1 10.6393613520272 1163 3647 3441 3006 3242 1026 743 2644 1617 4245 2407 2763 M10889 GO_COFACTOR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COFACTOR_TRANSPORT.html The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein. 25/27 Gene Ontology BP GO:0051181 2.19906410238946e-08 1.97691467186943e-07 3720 2378.45454545455 2645 1.99914920397341e-09 74 2.80553233664209 -2.49652517247176 -1 20.185436223204 3717 2405 1934 2715 169 3208 2080 3456 74 2645 3760 2764 M10467 GO_MYELOID_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 106/127 Gene Ontology BP GO:0002262 8.8370581534518e-08 2.45926026244086e-07 2330 2875.54545454545 2647 8.03368955311157e-09 1600 1.57812689459011 -1.49424895631352 -1 11.1434476575718 2330 4124 3552 2647 1600 2091 2609 2584 3486 3428 3180 2765 M10854 GO_LUNG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LUNG_CELL_DIFFERENTIATION.html The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. 24/33 Gene Ontology BP GO:0060479 6.79242219675908e-07 1.01591579818451e-06 3960 2554.45454545455 2647 6.17493117626939e-08 864 2.11761873465696 -2.03305857593773 -1 13.5836345006799 3958 1894 2075 1225 3075 3640 4159 2647 864 2878 1684 2766 M13362 GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 29/39 Gene Ontology BP GO:0098901 1.1723438218849e-07 2.82053557561036e-07 2755 2133.09090909091 2649 1.06576716759743e-08 640 2.36663818952813 2.91635586988078 1 16.6157407645052 2753 640 1340 1709 1875 3115 3296 2652 2649 659 2776 2767 M13270 GO_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of chemokine production. 76/124 Gene Ontology BP GO:0032642 3.30106443518553e-07 5.70362154360129e-07 3360 2909.81818181818 2650 3.00096811864093e-08 1388 2.26842537756883 2.23209535890389 1 15.1728199282046 3356 3895 1388 3461 2650 2452 2406 2612 3593 1707 4488 2768 M15446 GO_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBRINOLYSIS.html A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. 18/29 Gene Ontology BP GO:0042730 3.42684330937293e-08 1.97691467186943e-07 2990 2106.90909090909 2651 3.1153121479558e-09 266 3.72643295392262 -4.17593205782098 -1 26.8483187566157 2987 830 266 1283 557 2977 2651 4155 3714 369 3387 2769 M15494 GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 64/90 Gene Ontology BP GO:0046889 3.30548931702177e-07 5.70901867187186e-07 2655 2601.36363636364 2651 3.00499073970003e-08 1616 2.14790889354602 -1.91707382897873 -1 14.3597603386632 2928 2676 2291 1616 2651 2906 4640 1821 2245 2654 2187 2770 M15760 GO_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 646/808 Gene Ontology BP GO:0010564 2.06794855571045e-07 4.06090283662756e-07 1630 2817.45454545455 2652 2.06794874814898e-08 1627 1.60746122622244 1.79543256552618 1 10.9748092916132 1627 3587 4570 3007 2398 1890 1999 2769 2652 4028 2465 2771 M14659 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_REGULATORY_REGION_DNA_BINDING.html Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding. 18/28 Gene Ontology BP GO:2000679 1.39180243395758e-05 1.57529961693132e-05 400 2083.09090909091 2653 1.26528294463571e-06 267 1.45136953855778 -1.57754641343304 -1 7.40957829431841 398 3186 2653 3487 4087 565 368 609 3503 3791 267 2772 M16416 GO_LEUKOTRIENE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_METABOLIC_PROCESS.html The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 29/54 Gene Ontology BP GO:0006691 9.75956975124338e-07 1.37693384028306e-06 3405 2462.90909090909 2653 8.87234007341386e-08 684 2.15181019860655 -2.95446199697734 -1 13.498112139114 3404 684 2007 2276 3261 2692 2713 1915 2653 2852 2635 2773 M12130 GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS.html Any process that modulates the frequency, rate or extent of removal of superoxide radicals. 9/10 Gene Ontology BP GO:2000121 3.47842156029736e-05 3.78068103715571e-05 2655 2736.90909090909 2654 3.47847600887135e-06 643 2.52949803280376 2.79788283466957 1 11.9597553661582 2654 3264 4346 3092 4272 2291 643 1794 2467 3007 2276 2774 M11966 GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 12/24 Gene Ontology BP GO:0045723 1.82566529221226e-05 2.03957277422897e-05 2275 2849 2655 1.6597094933024e-06 1362 1.83829473332414 -1.99033926168753 -1 9.1925211185075 2274 2541 2655 2392 4144 2937 4117 1362 4304 3067 1546 2775 M10641 GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. 48/66 Gene Ontology BP GO:2000351 7.64684010903879e-08 2.29998364753442e-07 2940 2387.18181818182 2659 6.95167306802768e-09 701 2.81098958747326 2.6637663657571 1 20.0254940623419 2936 1757 701 1140 1455 3133 3219 4180 2659 1153 3926 2776 M12041 GO_BILE_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BILE_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. 18/33 Gene Ontology BP GO:0006699 6.015056595794e-08 2.09491454642436e-07 4020 2729.90909090909 2660 5.46823341841151e-09 873 3.12441787357089 -2.25061883255538 -1 22.4077299896676 4018 873 885 2245 1222 3925 4152 4344 2660 1487 4218 2777 M13102 GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_KETONE_METABOLIC_PROCESS.html Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 167/252 Gene Ontology BP GO:0010565 2.00235108999232e-07 3.97760141854629e-07 2360 3002.36363636364 2660 1.8203193383984e-08 2300 1.69625064371508 -1.46130033574875 -1 11.6037370480408 2360 4107 3712 2660 2300 2311 2463 3509 3038 3979 2587 2778 M14756 GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CDP_DIACYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis. 14/14 Gene Ontology BP GO:0046341 1.37961035922104e-06 1.85208511294157e-06 2565 2770.72727272727 2660 1.254192022154e-07 1002 1.34967434795681 -1.20446410352648 -1 8.23669070071308 2565 3521 3217 3894 3434 2156 1002 2197 2466 3366 2660 2779 M12729 GO_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. 845/1026 Gene Ontology BP GO:0009894 6.19907176474942e-08 2.12948256567067e-07 2635 2980.27272727273 2662 6.19907193767762e-09 1347 1.5279529382481 -1.38233218351684 -1 10.8886778281392 2635 3585 4383 4468 1347 1599 3132 2662 2600 4503 1869 2780 M16054 GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the rate of production of a cytokine. 203/317 Gene Ontology BP GO:0001818 4.51550510138778e-07 7.29030022094286e-07 2690 2756.90909090909 2663 4.10500548017865e-08 1522 2.10654041500923 -1.99053787964196 -1 13.8396114145374 2686 3320 1522 2321 2847 2368 3871 4445 2646 1637 2663 2781 M14542 GO_ICOSANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. 75/162 Gene Ontology BP GO:0006690 4.67378374442923e-07 7.49642046288493e-07 2675 2584.27272727273 2664 4.24889521577289e-08 1188 2.2929519694344 -2.61640552535343 -1 15.0443476980201 2675 2664 1188 2698 2864 1743 2646 3674 3536 2483 2256 2782 M12249 GO_EPITHELIAL_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CELL_CELL_ADHESION.html The attachment of an epithelial cell to another epithelial cell via adhesion molecules. 20/22 Gene Ontology BP GO:0090136 1.36037978418813e-06 1.82943558838942e-06 2665 2687.36363636364 2665 1.23670965944159e-07 540 1.97373246864651 2.26290511618236 1 12.1088221660399 1929 3481 2664 3208 3428 1318 540 4309 3610 2665 2409 2783 M16181 GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fatty acid derivative. 75/162 Gene Ontology BP GO:1901568 4.67378374442923e-07 7.49642046288493e-07 2680 2590.09090909091 2665 4.24889521577289e-08 1189 2.2929519694344 -2.61640552535343 -1 15.0443476980201 2676 2665 1189 2699 2865 1744 2647 3728 3537 2484 2257 2784 M15644 GO_GTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GTP, guanosine triphosphate. 25/28 Gene Ontology BP GO:0046039 1.74454732668475e-07 3.62221272247396e-07 3030 2713.09090909091 2667 1.58595224093017e-08 799 1.82323048027557 2.34489561405915 1 12.5608302405759 3026 799 2622 4114 2197 3269 2667 2323 1653 3305 3869 2785 M10063 GO_CARDIAC_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_ADAPTATION.html The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. 12/17 Gene Ontology BP GO:0014887 3.42374194799171e-06 4.17361050144234e-06 2295 2856.36363636364 2668 3.11249752380836e-07 2035 1.28739739171208 -0.67692359219805 -1 7.36116194536962 2291 2042 3159 2035 3788 2218 2668 3713 2359 4078 3069 2786 M11498 GO_DRUG_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSMEMBRANE_TRANSPORT.html The process in which a drug is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. 28/45 Gene Ontology BP GO:0006855 1.24727230932452e-07 2.91051055932147e-07 3320 2792.18181818182 2668 1.13388398185239e-08 1601 2.48853888670166 -2.7643255214067 -1 17.4407824244204 3316 2383 1601 2247 1931 4132 4265 2535 2668 2723 2913 2787 M13391 GO_VITAMIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 14/24 Gene Ontology BP GO:0009110 7.52367325149241e-07 1.10573757546413e-06 2830 2292.27272727273 2668 6.83970529498015e-08 34 2.89858464498284 -2.89355186881063 -1 18.5198107858706 2827 977 1616 1703 3135 2668 3331 3724 34 1958 3242 2788 M16863 GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. 10/15 Gene Ontology BP GO:0043568 3.68899641447886e-07 6.24859858630147e-07 2175 2272.81818181818 2668 3.35363366641457e-08 285 3.77921775520758 4.94255751681948 1 25.191738295928 2175 3263 1590 3044 2714 3522 3107 545 285 2088 2668 2789 M13627 GO_ORGAN_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGAN_INDUCTION.html The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. 12/25 Gene Ontology BP GO:0001759 0.00645436198247037 0.00655866920821896 2670 2743.36363636364 2669 0.000588488721624953 1570 2.53428451150358 -1.16269024964509 -1 5.85808513824439 2669 4058 2800 2050 4564 2896 1895 2361 1817 3497 1570 2790 M13805 GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. 12/17 Gene Ontology BP GO:0003299 3.42374194799171e-06 4.17361050144234e-06 2295 2855.09090909091 2669 3.11249752380836e-07 2036 1.28739739171208 -0.67692359219805 -1 7.36116194536962 2292 2043 3160 2036 3789 2219 2669 3688 2360 4080 3070 2791 M14830 GO_CELLULAR_WATER_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_WATER_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of water within a cell. 7/16 Gene Ontology BP GO:0009992 3.07820289140388e-07 5.4031661702426e-07 3090 2612.45454545455 2669 3.07820331779395e-08 854 3.49182716819855 3.34903298625147 1 23.5053531996806 3090 1110 4519 921 2669 3854 4346 3629 854 2515 1230 2792 M15814 GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 33/56 Gene Ontology BP GO:0007215 8.14493177544975e-07 1.18210753434709e-06 3985 2474.81818181818 2670 7.40448617354721e-08 694 2.33151287408952 2.41056866089955 1 14.8015322929376 3984 1816 1113 1493 3171 2670 3632 4287 694 1438 2925 2793 M16881 GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_MUSCLE_HYPERTROPHY_IN_RESPONSE_TO_STRESS.html The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. 12/17 Gene Ontology BP GO:0014898 3.42374194799171e-06 4.17361050144234e-06 2295 2857.90909090909 2670 3.11249752380836e-07 2037 1.28739739171208 -0.67692359219805 -1 7.36116194536962 2293 2044 3161 2037 3790 2220 2670 3708 2361 4082 3071 2794 M11796 GO_MEMBRANE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a membrane. 32/40 Gene Ontology BP GO:0071709 3.40395645702232e-07 5.84019520447082e-07 3625 2382.72727272727 2671 3.09450634881873e-08 115 2.38972654776603 2.55378811740397 1 15.9637107735738 3622 507 891 115 2671 4601 4393 4446 141 596 4227 2795 M13264 GO_NEUTRAL_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. 14/30 Gene Ontology BP GO:0046461 2.96456016895268e-07 5.2528935514611e-07 2675 2800.45454545455 2672 2.69505506221396e-08 1734 2.38524278443048 -2.48148103328174 -1 16.0520349820101 2672 2518 1734 4093 2585 3074 3019 3739 3355 1957 2059 2796 M16301 GO_REGULATION_OF_NEUTROPHIL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_MIGRATION.html Any process that modulates the frequency, rate or extent of neutrophil migration. 31/60 Gene Ontology BP GO:1902622 3.41000113771414e-07 5.84649550967766e-07 4225 2728.72727272727 2672 3.100001514786e-08 536 2.65357664182674 -2.95359887577443 -1 17.7374127856649 4224 1837 941 1866 2672 4400 4013 4282 2691 536 2554 2797 M14211 GO_ACYLGLYCEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACYLGLYCEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. 14/30 Gene Ontology BP GO:0046464 2.96456016895268e-07 5.2528935514611e-07 2675 2800.63636363636 2673 2.69505506221396e-08 1735 2.38524278443048 -2.48148103328174 -1 16.0520349820101 2673 2519 1735 4094 2586 3075 3020 3726 3356 1963 2060 2798 M13459 GO_ERYTHROCYTE_MATURATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_MATURATION.html A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. 12/16 Gene Ontology BP GO:0043249 4.05013742411372e-07 6.71367632148241e-07 2675 2349.09090909091 2674 3.68194379066608e-08 768 1.52606003929999 -2.05368712328201 -1 10.0537259109637 2674 2931 2936 2365 2769 2457 2743 768 2975 2020 1202 2799 M14545 GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_SENESCENCE.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence. 17/21 Gene Ontology BP GO:2000773 5.83995724855438e-06 6.88804083080444e-06 1445 2520.81818181818 2674 5.30906613720952e-07 919 2.48388040839657 2.80706248230633 1 13.7243258624763 1441 4026 2930 2674 3919 1241 919 2031 3238 4121 1189 2800 M13282 GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition. 179/212 Gene Ontology BP GO:1902806 2.28308633051053e-07 4.33808900180104e-07 2095 2714.27272727273 2675 2.07553324312874e-08 1773 1.70381480804026 1.77921006016866 1 11.5867052124886 2093 3607 3440 2649 2402 1859 1773 2841 2675 3784 2734 2801 M13988 GO_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIGESTIVE_SYSTEM_PROCESS.html A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 67/119 Gene Ontology BP GO:0022600 1.04794877110313e-07 2.64657043934525e-07 2675 2499.36363636364 2675 9.52680746382872e-09 281 3.57659844227717 -3.63659721287842 -1 25.2751970411814 3267 2675 281 2067 1773 4379 4320 2038 2968 1050 2675 2802 M10932 GO_T_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 38/50 Gene Ontology BP GO:0043029 2.24793145311413e-08 1.97691467186943e-07 4315 2459.18181818182 2676 2.04357406916655e-09 188 1.84425089639502 -1.40713142752436 -1 13.2303911317705 4314 553 2676 670 188 4209 4642 3797 637 2670 2695 2803 M15111 GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. 10/14 Gene Ontology BP GO:0033033 3.42036594555301e-07 5.85754977720211e-07 1540 2609.81818181818 2676 3.10942407029222e-08 1160 1.53804505335627 1.30681651177148 1 10.2319119283163 1538 4064 2966 3735 2676 1727 1160 1469 4153 3651 1569 2804 M10507 GO_POSITIVE_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_DEATH.html Any process that activates or increases the frequency, rate or extent of neuron death. 94/112 Gene Ontology BP GO:1901216 5.68443243260982e-08 2.0634742747708e-07 2605 2822.90909090909 2677 5.16766598135098e-09 1161 1.90769330455959 2.33450332284244 1 13.6510910324647 2604 4126 3052 2677 1161 2861 2186 2140 2275 4322 3648 2805 M12688 GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. 7/16 Gene Ontology BP GO:2001053 3.11007898639421e-07 5.45054520666375e-07 3455 2611.72727272727 2677 3.1100794216609e-08 991 3.60842061679472 3.45455416416281 1 24.2792165413587 3454 3281 4382 1220 2677 3773 2345 1503 991 1840 3263 2806 M14806 GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. 79/110 Gene Ontology BP GO:0008543 1.96803876942101e-07 3.93237507536888e-07 2000 3000.09090909091 2678 1.78912631406774e-08 1866 1.69004477772263 2.15283749686053 1 11.5699284193685 1996 4138 3219 4007 2288 2306 1866 4510 2678 3515 2478 2807 M10608 GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-10 production. 31/70 Gene Ontology BP GO:0032653 3.44682088854037e-07 5.89709098691682e-07 4380 2820 2679 3.13347402596963e-08 1034 2.41747650610221 -2.38675882734193 -1 16.1394125509715 4378 2760 1439 2145 2679 4257 2445 3993 1034 1770 4120 2808 M14005 GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell. 77/145 Gene Ontology BP GO:0050715 9.34661946401626e-08 2.50783780632741e-07 4285 2313 2680 8.4969271464582e-09 654 2.29443256216767 1.95050351917682 1 16.2317144586658 4283 1681 718 769 1667 3362 2829 2680 2798 654 4002 2809 M16601 GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 243/322 Gene Ontology BP GO:0034599 9.0783727222221e-08 2.48480401626467e-07 3395 2589.45454545455 2682 8.2530664516765e-09 1632 1.92904242374732 2.10142309169952 1 13.6371333793598 3393 2148 1949 2437 1632 2994 3240 2346 2755 2908 2682 2810 M14102 GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 58/103 Gene Ontology BP GO:0045912 3.68043234443019e-07 6.24090805343792e-07 3115 2700 2683 3.34584814558056e-08 1006 1.89092293126349 -1.12416363856118 -1 12.5492104056098 3115 2683 2435 4103 2711 2866 2219 1006 2474 3435 2653 2811 M10645 GO_STEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of sterol within an organism or cell. 55/94 Gene Ontology BP GO:0055092 4.60096985055635e-08 1.97760774550163e-07 4485 2903 2685 4.18269995161702e-09 924 2.68583955999146 -2.49449242434324 -1 19.3189960750196 4484 2685 1117 2295 924 4376 4340 2541 3300 1580 4291 2812 M16934 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. 8/21 Gene Ontology BP GO:0023019 9.66812356349731e-07 1.36687740296113e-06 3800 2714.09090909091 2685 9.66812776976749e-08 731 2.62364375859274 -2.45324627788995 -1 16.4916951084286 3800 2078 4652 1195 3310 3468 3437 2354 731 2145 2685 2813 M12063 GO_PEPTIDYL_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_AMINO_ACID_MODIFICATION.html The alteration of an amino acid residue in a peptide. 830/1025 Gene Ontology BP GO:0018193 2.58068103273519e-07 4.7126800805796e-07 1920 3139.36363636364 2686 2.58068133243139e-08 1920 1.80283433162585 1.91624903855764 1 12.1966702511785 1920 4320 4341 4062 2556 2532 2255 2145 2686 4490 3226 2814 M13144 GO_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. 55/94 Gene Ontology BP GO:0042632 4.60096985055635e-08 1.97760774550163e-07 4485 2876.36363636364 2686 4.18269995161702e-09 925 2.68583955999146 -2.49449242434324 -1 19.3189960750196 4485 2686 1118 2296 925 4377 4341 2237 3301 1582 4292 2815 M16938 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. 37/42 Gene Ontology BP GO:0032108 5.93450116693791e-07 9.07459767291438e-07 3825 2832.27272727273 2691 5.39500251615501e-08 1447 2.08360843021539 -1.27752014415282 -1 13.4739105735501 3822 1809 2234 2881 2999 4035 4231 2691 1447 2539 2467 2816 M10171 GO_OLIGOSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. 56/71 Gene Ontology BP GO:0009311 1.84953863388508e-08 1.97691467186943e-07 4455 2511.63636363636 2692 1.68139877221286e-09 93 1.8099902312345 -1.56536671146195 -1 12.9825090224554 4453 324 1768 2692 93 3528 3126 4430 1558 1232 4424 2817 M12821 GO_REGULATION_OF_STEROID_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEROID_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of steroid hormone secretion. 15/30 Gene Ontology BP GO:2000831 1.09318668995329e-06 1.51657652604432e-06 2400 2491.36363636364 2692 9.93806575601326e-08 468 2.23464440769395 -2.40355381065278 -1 13.9209036186285 2397 3801 2142 3406 3319 2885 1764 468 2772 2692 1759 2818 M13615 GO_DIOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. 10/12 Gene Ontology BP GO:0034311 1.75644667296837e-05 1.96554746736936e-05 3495 2532.81818181818 2692 1.59678245120843e-06 78 1.76123855193428 -2.23389491429551 -1 8.83297392780748 3493 2059 2692 1176 4136 3953 4243 1133 78 3649 1249 2819 M15328 GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 10/18 Gene Ontology BP GO:0060457 1.86408860017886e-07 3.79588807730076e-07 3520 2637.81818181818 2693 1.69462614375048e-08 1089 3.83912473589537 5.49739776796425 1 26.4897605354519 3516 1089 1330 2283 2243 3091 2878 4442 2693 2084 3367 2820 M12071 GO_HOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. 11/13 Gene Ontology BP GO:0050667 8.9905407979686e-08 2.4768192782905e-07 3805 2868 2694 8.17321924125175e-09 1071 1.85725162811683 -1.3375020027014 -1 13.1282097665374 3803 1071 2478 1548 1618 4642 4131 4268 2694 2337 2958 2821 M13497 GO_PROTEIN_ADP_RIBOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ADP_RIBOSYLATION.html The transfer, from NAD, of ADP-ribose to protein amino acids. 18/22 Gene Ontology BP GO:0006471 1.07658006332968e-06 1.49621476543399e-06 2870 2387.18181818182 2694 9.78709627417656e-08 124 1.70798892831731 -1.18620634209103 -1 10.6242258116536 2869 2462 3155 1626 3313 2189 2694 2853 124 3484 1490 2822 M14917 GO_REGULATION_OF_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_DEATH.html Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death. 1539/2183 Gene Ontology BP GO:0010941 4.83972076813864e-08 1.9910893664146e-07 2775 2596.54545454545 2694 4.83972087354168e-09 1085 2.0192518161734 2.14160280423497 1 14.4897926314087 2772 2095 4525 2694 1085 2097 2820 3532 2170 1180 3592 2823 M15407 GO_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. 794/1446 Gene Ontology BP GO:0009607 1.09126781655193e-07 2.69381577639745e-07 2695 2689.54545454545 2694 1.09126787014087e-08 357 2.11310037054377 -2.04466929756242 -1 14.8691089051365 2434 2975 4554 2695 1900 2694 3664 2520 3291 357 2501 2824 M10779 GO_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. 12/21 Gene Ontology BP GO:0043501 1.96040486901453e-05 2.18485361808973e-05 2700 2413.90909090909 2696 1.78220212569584e-06 585 4.6934165095747 6.48148614866016 1 23.494046366401 2696 4285 1638 4100 4154 3266 983 585 1161 3064 621 2825 M14660 GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 15/35 Gene Ontology BP GO:0032660 3.84272742684176e-05 4.1630292705692e-05 1910 2709.45454545455 2696 3.49344959016682e-06 745 2.04442116418488 -1.59604991684161 -1 9.55225339176511 1910 4029 2450 3696 4274 1445 745 3393 3233 2696 1933 2826 M10224 GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of cell cycle checkpoint. 40/42 Gene Ontology BP GO:1901976 1.11992132310078e-07 2.7397444355352e-07 2040 2915.54545454545 2697 1.01811034555542e-08 1399 1.55162677933194 1.51473818436696 1 10.8758798754495 2038 4442 3571 4521 1834 1963 1399 3743 2697 3390 2473 2827 M13047 GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. 21/22 Gene Ontology BP GO:1903055 2.13309334984058e-07 4.14071062027877e-07 2695 2832.90909090909 2700 1.9391759606025e-08 1958 1.69236366567735 1.92989113292216 1 11.5450095865213 2694 1958 2566 3385 2355 2700 3605 3102 3957 1993 2847 2828 M10200 GO_N_GLYCAN_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_GLYCAN_PROCESSING.html The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. 17/20 Gene Ontology BP GO:0006491 2.01399900090601e-07 3.99352934032239e-07 3835 3012.27272727273 2702 1.83090835025308e-08 179 1.713361224581 -1.41424542714177 -1 11.7187188641446 3831 1988 2702 2086 2305 4082 4317 4649 179 2591 4405 2829 M14750 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. 28/30 Gene Ontology BP GO:1904376 1.13069509272441e-08 1.77740684677253e-07 1805 2672.72727272727 2702 1.0279046350324e-09 7 1.28978495963752 -1.32712012802256 -1 9.2830406038217 1803 2384 3420 4510 7 2702 1871 2763 4154 3581 2205 2830 M15399 GO_LYMPHOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MIGRATION.html The movement of a lymphocyte within or between different tissues and organs of the body. 33/74 Gene Ontology BP GO:0072676 3.61452102847537e-07 6.14257353743458e-07 4395 2637 2702 3.28592874757121e-08 591 2.47550768223431 2.12392032001202 1 16.482230101236 4391 591 1204 1145 2702 4223 4302 779 3250 2038 4382 2831 M16879 GO_INOSITOL_LIPID_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_LIPID_MEDIATED_SIGNALING.html A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. 120/158 Gene Ontology BP GO:0048017 4.43152509192588e-08 1.97691467186943e-07 3875 2456.36363636364 2702 4.02865925562854e-09 300 2.31461062391236 -2.32432044950736 -1 16.6335288364126 3875 1608 1214 300 862 4083 4209 3962 930 2702 3275 2832 M16531 GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. 28/30 Gene Ontology BP GO:1903077 1.13069509272441e-08 1.77740684677253e-07 1805 2671.36363636364 2703 1.0279046350324e-09 8 1.28978495963752 -1.32712012802256 -1 9.2830406038217 1804 2385 3421 4511 8 2703 1872 2736 4155 3584 2206 2833 M14851 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION.html Any process that activates or increases the frequency, rate or extent of epithelial cell migration. 130/152 Gene Ontology BP GO:0010634 5.79333871098431e-08 2.0762333639785e-07 1185 2225.18181818182 2704 5.26667169412943e-09 12 2.1731109072134 2.12556466277318 1 15.5598256998961 3756 12 872 1183 1182 3475 3011 3516 2704 759 4007 2834 M16724 GO_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_SELECTION.html The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. 29/47 Gene Ontology BP GO:0045058 6.18927619044271e-07 9.38986048716333e-07 2720 2619.36363636364 2704 5.62661630152457e-08 1479 2.05860242001919 2.02646527778317 1 13.2778969609258 2719 2382 1965 3163 3026 2704 2374 1479 3388 1833 3780 2835 M13561 GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXCITATORY_POSTSYNAPTIC_POTENTIAL.html Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. 23/31 Gene Ontology BP GO:2000463 3.64726822120148e-07 6.19370037709871e-07 4400 2176.72727272727 2706 3.31569893260336e-08 540 2.79566631753843 2.89020033745937 1 18.6176507706678 4397 687 747 581 2706 3819 3881 2825 540 627 3134 2836 M14390 GO_CELL_FATE_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_DETERMINATION.html A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. 33/63 Gene Ontology BP GO:0001709 4.04143371007943e-07 6.70402533083765e-07 3155 2257.72727272727 2707 3.67403132045199e-08 739 3.21092555474833 3.66025766349977 1 21.2806985817477 3153 2735 895 1161 2768 2783 2275 3895 739 1724 2707 2837 M11211 GO_GLUCOSE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. 178/263 Gene Ontology BP GO:0042593 4.73933283075117e-08 1.98252330758246e-07 2780 2656.09090909091 2709 4.30848448440715e-09 959 1.89300736677476 2.00955653043861 1 13.5806393615205 2791 3003 2777 2580 959 2709 2638 2681 2223 2779 4077 2838 M12930 GO_IMMUNOGLOBULIN_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 33/81 Gene Ontology BP GO:0002377 1.50614861892741e-06 1.99889033766949e-06 1235 2626 2709 1.36922695459758e-07 462 1.87510885183048 1.81489888809853 1 11.4202617592168 1234 3954 2868 3923 3475 1315 462 1983 4275 2709 2688 2839 M14445 GO_CARBOHYDRATE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_HOMEOSTASIS.html A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell. 178/263 Gene Ontology BP GO:0033500 4.73933283075117e-08 1.98252330758246e-07 2780 2650.45454545455 2710 4.30848448440715e-09 960 1.89300736677476 2.00955653043861 1 13.5806393615205 2792 3004 2778 2581 960 2710 2639 2609 2224 2780 4078 2840 M11092 GO_WHITE_FAT_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_WHITE_FAT_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. 18/20 Gene Ontology BP GO:0050872 5.70664050444263e-07 8.80696459939355e-07 2130 2419.54545454545 2711 5.18785634973122e-08 527 1.82041676466745 2.22885153283785 1 11.7832059601699 2128 934 2711 3488 2977 2066 527 955 3980 3785 3064 2841 M10707 GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLL_LIKE_RECEPTOR_9_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of binding to toll-like receptor 9. 31/53 Gene Ontology BP GO:0034162 2.40144970525424e-06 3.02899037098074e-06 2095 2592.54545454545 2712 2.18313847873091e-07 1209 2.02697309315821 -1.89328347753808 -1 11.9594669890584 2095 3428 2126 2876 3659 2460 2712 1209 3105 3079 1769 2842 M11372 GO_ORGANOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound. 809/1043 Gene Ontology BP GO:0019637 2.82392192014808e-08 1.97691467186943e-07 1705 2746.09090909091 2712 2.82392195603349e-09 447 1.67940929498503 -1.56032316613629 -1 12.0377323299363 1701 3293 4295 4363 447 1944 2208 2552 2760 3932 2712 2843 M11533 GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REGULATED_SECRETORY_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway. 22/36 Gene Ontology BP GO:1903306 3.56930270001603e-06 4.34081690098656e-06 2985 2630.81818181818 2713 3.24482590082065e-07 537 1.93343450043678 -2.15330186633377 -1 11.0762710548533 2985 1939 2713 1801 3801 3860 4357 890 537 3594 2462 2844 M12870 GO_POSITIVE_REGULATION_OF_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_ADHESION.html Any process that activates or increases the frequency, rate or extent of cell adhesion. 385/579 Gene Ontology BP GO:0045785 4.63431038778914e-10 9.21514796341147e-09 3900 2319.81818181818 2713 4.21300944433215e-11 172 2.28090075781732 2.58768198391157 1 19.6672433372404 3897 1319 172 917 832 4175 4359 2819 2713 185 4130 2845 M10068 GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_ENVIRONMENT_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0052192 6.28517031778016e-08 2.12948256567067e-07 3230 2754.90909090909 2714 5.71379136121903e-09 1257 1.78731658307837 1.82263322221903 1 12.756183380409 3229 1649 2254 2737 1257 2617 2714 4386 3569 1439 4453 2846 M13999 GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_GLUTAMIC_ACID_MODIFICATION.html The modification of peptidyl-glutamic acid. 24/35 Gene Ontology BP GO:0018200 1.44817509478603e-07 3.19401131586796e-07 2715 2587.27272727273 2714 1.31652290010347e-08 919 2.43017432597515 -2.94962697487668 -1 16.9232131453958 2714 3133 1871 3043 2052 2661 3773 3457 919 2111 2726 2847 M10524 GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_CELL_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0051806 6.28517031778016e-08 2.12948256567067e-07 3230 2750.90909090909 2715 5.71379136121903e-09 1258 1.78731658307837 1.82263322221903 1 12.756183380409 3230 1650 2255 2738 1258 2618 2715 4332 3570 1440 4454 2848 M12571 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter. 32/32 Gene Ontology BP GO:0006359 7.12569472509249e-06 8.31807766077656e-06 2715 2860.09090909091 2715 6.4779252772558e-07 303 2.17816571050437 -1.5220904010924 -1 11.828632938051 2715 4187 2674 3660 3960 2062 1525 4518 303 3664 2193 2849 M14528 GO_MITOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_RECOMBINATION.html The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles. 41/43 Gene Ontology BP GO:0006312 4.69897709656301e-05 5.06470707211204e-05 50 2104 2715 4.27188860450372e-06 19 1.1824899193228 1.23968215878503 1 5.36866565623276 49 2715 3500 3116 4309 308 19 924 3828 2992 1384 2850 M16480 GO_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VIRUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. 263/439 Gene Ontology BP GO:0009615 5.01929850109593e-07 7.91956457293977e-07 2370 2920.54545454545 2715 4.56299967840811e-08 2333 1.94112059895051 -1.90480425604681 -1 12.6686255677481 2333 3597 2369 3886 2915 2715 3484 2464 3481 2369 2513 2851 M12914 GO_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_ENTRY_INTO_HOST_CELL.html The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. 92/135 Gene Ontology BP GO:0046718 6.28517031778016e-08 2.12948256567067e-07 3235 2758.54545454545 2716 5.71379136121903e-09 1259 1.78731658307837 1.82263322221903 1 12.756183380409 3231 1651 2256 2739 1259 2619 2716 4406 3571 1441 4455 2852 M10093 GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 114/171 Gene Ontology BP GO:0008277 5.79915835108795e-08 2.0762333639785e-07 1185 2319.09090909091 2717 5.27196227632063e-09 1183 1.97392220029356 1.96129222382261 1 14.1232357257573 2861 1622 1677 2732 1183 2739 2190 2717 2986 1184 3619 2853 M12938 GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction. 92/135 Gene Ontology BP GO:0051828 6.28517031778016e-08 2.12948256567067e-07 3235 2759.54545454545 2717 5.71379136121903e-09 1260 1.78731658307837 1.82263322221903 1 12.756183380409 3232 1652 2257 2740 1260 2620 2717 4407 3572 1442 4456 2854 M13071 GO_RESPONSE_TO_SALT_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_SALT_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. 18/30 Gene Ontology BP GO:0009651 8.81123450423933e-07 1.26617276554125e-06 4600 3056.09090909091 2718 8.01021639384969e-08 1516 2.46922078964376 -2.34915825377347 -1 15.6029376695397 4597 2471 1516 1771 3207 4567 4145 2277 2718 2322 4026 2855 M15136 GO_MOVEMENT_IN_HOST_ENVIRONMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOVEMENT_IN_HOST_ENVIRONMENT.html The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0052126 6.28517031778016e-08 2.12948256567067e-07 3235 2756.81818181818 2718 5.71379136121903e-09 1261 1.78731658307837 1.82263322221903 1 12.756183380409 3233 1653 2258 2741 1261 2621 2718 4367 3573 1443 4457 2856 M16666 GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. 23/39 Gene Ontology BP GO:0035458 6.9535697943086e-06 8.12530393091861e-06 565 2276.09090909091 2718 6.3214470660437e-07 279 1.81461445761992 -1.87565750890893 -1 9.85541666314601 561 3459 2718 2964 3955 1169 279 1717 3491 3105 1619 2857 M16732 GO_THYROID_HORMONE_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_HORMONE_GENERATION.html The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. 6/13 Gene Ontology BP GO:0006590 4.93038524190626e-07 7.81105976526722e-07 2720 2551.45454545455 2718 4.93038633579804e-08 279 3.86537377292285 2.81005248007381 1 25.3642753404045 2718 2962 4644 1702 2957 2570 2468 525 279 2930 4311 2858 M12252 GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of muscle contraction. 40/61 Gene Ontology BP GO:0045933 2.00022825319971e-07 3.97760141854629e-07 2625 2395 2719 1.81838948641766e-08 974 2.40111454071941 2.31274237898825 1 16.4725775219543 2625 2719 974 2782 2297 2831 2907 1649 3489 1228 2844 2859 M14244 GO_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 41/61 Gene Ontology BP GO:0009268 2.62208797495334e-07 4.76584974510074e-07 4240 2838.09090909091 2719 2.3837166249719e-08 491 2.08801447683287 -2.08465153927241 -1 14.1329029880394 4238 491 1839 2270 2519 4121 4538 3307 1724 2719 3453 2860 M15286 GO_ENTRY_INTO_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST.html Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0044409 6.28517031778016e-08 2.12948256567067e-07 3235 2757.09090909091 2719 5.71379136121903e-09 1262 1.78731658307837 1.82263322221903 1 12.756183380409 3234 1654 2259 2742 1262 2622 2719 4360 3574 1444 4458 2861 M12794 GO_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION.html The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. 232/316 Gene Ontology BP GO:0019882 1.16500815486347e-07 2.81745475290006e-07 1535 2355.81818181818 2720 1.05909837868762e-08 1249 1.66608135714184 -1.59740995891858 -1 11.6646323252212 1532 2994 3578 3146 1864 1249 1316 2720 3087 2998 1430 2862 M14749 GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN.html An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. 31/224 Gene Ontology BP GO:0002455 2.01780981581326e-07 3.99633168316993e-07 2700 2735.63636363636 2720 1.83437272807639e-08 969 2.5192671102478 -2.95540139617594 -1 17.283168022014 2698 2752 969 2720 2308 3997 4312 4052 3439 985 1860 2863 M15419 GO_HYDROGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_TRANSPORT.html The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 113/157 Gene Ontology BP GO:0006818 3.71462904541725e-07 6.27830328671503e-07 410 2644.27272727273 2720 3.37693606601867e-08 410 1.28602325042107 -1.11828806895316 -1 8.49498104927278 410 3886 4032 4015 2720 1267 1056 1221 4055 4101 2324 2864 M16749 GO_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRY_INTO_HOST_CELL.html The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. 92/135 Gene Ontology BP GO:0030260 6.28517031778016e-08 2.12948256567067e-07 3235 2760.45454545455 2720 5.71379136121903e-09 1263 1.78731658307837 1.82263322221903 1 12.756183380409 3235 1655 2260 2743 1263 2623 2720 4387 3575 1445 4459 2865 M14589 GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that activates or increases the frequency, rate or extent of protein acetylation. 41/48 Gene Ontology BP GO:1901985 2.97555225823574e-06 3.66664318261941e-06 1380 2449.09090909091 2721 2.70505116613497e-07 848 1.65683015001156 1.68201822370976 1 9.60655124068862 1378 2721 2977 2209 3747 1216 848 2461 2847 3446 3090 2866 M11871 GO_MACROAUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROAUTOPHAGY.html The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. 304/417 Gene Ontology BP GO:0016236 7.47152002771485e-08 2.28432407164829e-07 1755 2484.81818181818 2722 6.79229116496233e-09 413 1.85605491795123 -1.50167915337745 -1 13.1900603835452 1753 3310 3035 4486 1428 413 1613 3359 2722 4145 1069 2867 M14061 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an extracellular stimulus. 61/86 Gene Ontology BP GO:0032106 4.25401825199348e-07 6.93308123521039e-07 2565 2477.54545454545 2722 3.86729006779061e-08 327 1.25142706642695 -1.15499121210618 -1 8.20522091982313 2563 327 3733 2039 2816 1300 2722 3441 3583 4153 576 2868 M12630 GO_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 104/139 Gene Ontology BP GO:0055076 2.78963762402873e-08 1.97691467186943e-07 1690 2537.09090909091 2723 2.53603423581983e-09 352 1.85091686630257 -1.99988067517144 -1 13.2786206297552 1689 3628 3046 4493 352 1454 1759 2723 3247 3449 2068 2869 M16372 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_NUTRIENT_LEVELS.html Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. 61/86 Gene Ontology BP GO:0032109 4.25401825199348e-07 6.93308123521039e-07 2565 2513.09090909091 2723 3.86729006779061e-08 328 1.25142706642695 -1.15499121210618 -1 8.20522091982313 2564 328 3734 2040 2817 1301 2723 3822 3584 4154 577 2870 M14671 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G1/S phase transition. 119/135 Gene Ontology BP GO:1902807 3.75756836326279e-07 6.33247576757036e-07 1785 2774.63636363636 2726 3.41597182277292e-08 1466 1.67351993194906 1.77937303513621 1 11.0819757668432 1782 3625 3521 3793 2726 1499 1466 2714 3202 3911 2282 2871 M15877 GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate or extent of the inflammatory response. 97/167 Gene Ontology BP GO:0050729 6.87055565852471e-08 2.20574996703632e-07 4535 2367.54545454545 2726 6.245959884628e-09 123 2.49490537561243 -2.59092019795753 -1 17.809912349418 3742 123 488 1859 1355 4533 4534 2726 2897 409 3377 2872 M13287 GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLLICLE_STIMULATING_HORMONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. 14/15 Gene Ontology BP GO:0032354 7.01870020962731e-07 1.0457256508292e-06 3460 2641.45454545455 2727 6.38063858983368e-08 1119 2.71097810361034 2.19136877081264 1 17.3847278261111 3457 2902 2283 2136 3088 3238 2099 2645 1119 3362 2727 2873 M14467 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage. 38/39 Gene Ontology BP GO:1902229 1.04833041198576e-06 1.46219466635784e-06 2070 2609.54545454545 2727 9.53028101390935e-08 1242 1.85911117022201 2.14124593605098 1 11.5943018288487 2068 3087 2727 3394 3298 2295 1242 1530 2185 3444 3435 2874 M14819 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. 55/70 Gene Ontology BP GO:1903201 4.54647858882808e-08 1.97760774550163e-07 2325 2844.45454545455 2727 4.13316243889522e-09 910 1.66955051634814 2.15164572612613 1 11.9661279908715 2324 4157 3433 3246 910 2727 2659 2052 3042 4251 2488 2875 M16625 GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that modulates the frequency, rate or extent of viral release from host cell. 39/50 Gene Ontology BP GO:1902186 8.51671425561635e-07 1.22726142556156e-06 835 2364.45454545455 2728 7.74247050239754e-08 831 1.52872068483491 -1.43268733740633 -1 9.63923097339149 831 2728 3152 4378 3196 1418 1142 1016 3398 3299 1451 2876 M11841 GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. 12/17 Gene Ontology BP GO:0060218 0.000271540517960555 0.000281774761389488 2730 2687.09090909091 2729 2.46885490293306e-05 1165 1.74964809746094 1.96917495563093 1 6.59046453379922 2729 3817 2768 3665 4472 2313 1165 1994 1733 3065 1837 2877 M16007 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process. 16/23 Gene Ontology BP GO:1903427 6.58139136735232e-08 2.17413460714792e-07 4345 2581.72727272727 2729 5.98308324021578e-09 956 1.97834137139637 -1.87995237308739 -1 14.1123840188181 4345 956 2486 1997 1305 3931 3138 2729 2923 1509 3080 2878 M11906 GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 38/53 Gene Ontology BP GO:0045744 1.98313394285987e-08 1.97691467186943e-07 2730 2461.45454545455 2730 1.80284905521484e-09 120 2.04595963529259 1.85907718300647 1 14.6897903416504 2730 1820 2115 2749 120 2245 2775 3582 3621 2378 2941 2879 M13382 GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. 17/19 Gene Ontology BP GO:0007095 3.78074213484165e-07 6.36001198605141e-07 1385 2327.90909090909 2731 3.43703889506326e-08 519 1.23572254655614 1.50989810150618 1 8.15080088318664 1381 3777 3443 3692 2731 1283 519 558 3455 3698 1070 2880 M15177 GO_INTRACELLULAR_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_LIPID_TRANSPORT.html The directed movement of lipids within cells. 37/57 Gene Ontology BP GO:0032365 1.4331487420597e-07 3.17544814133514e-07 3705 2423.54545454545 2731 1.30286257765409e-08 231 1.95123359754287 -1.57987919052 -1 13.5710139407304 3701 2731 2848 2013 2045 2508 3006 969 3468 3139 231 2881 M15836 GO_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that modulates the frequency, rate or extent of viral genome replication. 95/138 Gene Ontology BP GO:0045069 1.51710912078704e-06 2.01114209088949e-06 510 2275.72727272727 2731 1.37919106089e-07 407 1.76143450764533 -2.05266018489817 -1 10.7160324087583 510 3355 2731 2834 3478 1908 2048 407 3132 2987 1643 2882 M12120 GO_RESPONSE_TO_XENOBIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_XENOBIOTIC_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms. 74/205 Gene Ontology BP GO:0009410 1.67754942498957e-08 1.97691467186943e-07 2955 2359.81818181818 2732 1.52504494343751e-09 57 2.78995845764816 -2.89199376562693 -1 20.0727563917662 2953 2257 549 3266 57 2951 2732 4498 2548 624 3523 2883 M13667 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. 40/49 Gene Ontology BP GO:0061418 6.2345258471267e-05 6.67800385973309e-05 1790 2831.27272727273 2732 5.66791139348179e-06 1318 1.76457861379732 2.23397807870385 1 7.83839839854985 1790 4173 3332 2675 4332 1534 1318 2732 3324 4241 1693 2884 M10058 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 38/48 Gene Ontology BP GO:0042992 7.02702162387792e-08 2.22275537837552e-07 2265 2894.90909090909 2733 6.38820168029826e-09 1376 1.37442019806965 -1.13707888583704 -1 9.75557463068785 2264 2733 3566 4180 1376 2633 2280 3382 3086 4196 2148 2885 M10235 GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that activates or increases the rate of gene expression. 77/111 Gene Ontology BP GO:0045815 8.96263526143779e-07 1.28475483276248e-06 2075 2740.72727272727 2734 8.14785355704578e-08 1257 1.98202790977484 2.09873512227792 1 12.4885299881 2074 3894 2881 4128 3214 2734 2218 1257 1386 3823 2539 2886 M14001 GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the Notch signaling pathway. 68/96 Gene Ontology BP GO:0008593 8.21687457709194e-07 1.19069191551569e-06 3645 2809.90909090909 2735 7.46988876913579e-08 676 2.80168890529494 -2.19898293458752 -1 17.799735049873 3641 2667 676 2089 3176 4386 4491 4305 1489 1254 2735 2887 M16489 GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. 19/25 Gene Ontology BP GO:0072525 3.98725477082371e-07 6.63781626069507e-07 1965 2509.63636363636 2736 3.62477772133579e-08 810 1.88889474194177 -2.13486390847048 -1 12.4810416315121 1965 2835 2365 4086 2759 2519 2935 3574 2736 1022 810 2888 M15078 GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol. 17/18 Gene Ontology BP GO:1904152 2.18451099735643e-07 4.19848396146199e-07 2740 2900.63636363636 2737 1.9859192856996e-08 1707 1.39678978046227 -1.27036831403742 -1 9.49983212560652 2737 3492 3297 2579 2379 2663 2162 3867 3635 3389 1707 2889 M10769 GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein. 144/160 Gene Ontology BP GO:0042787 1.89360779049838e-07 3.82918602746153e-07 1390 2820.18181818182 2738 1.72146177589733e-08 1388 1.466306993946 1.70829834649211 1 10.0415379484263 1388 3879 4005 3568 2261 2098 2738 2095 2931 4102 1957 2890 M14926 GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of keratinocyte differentiation. 36/44 Gene Ontology BP GO:0045616 1.60300052300465e-06 2.11116938396282e-06 2805 2410.36363636364 2738 1.45727426455518e-07 1281 2.60823002267514 -2.81895919473326 -1 15.8627111984826 2801 2738 1598 1434 3498 3309 3828 1427 1281 2747 1853 2891 M16043 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. 77/151 Gene Ontology BP GO:0032729 1.53121586378165e-06 2.02637867297383e-06 1845 2566.18181818182 2738 1.3920153904727e-07 342 1.66365990326879 -1.65987063357969 -1 10.109038240583 1842 3036 2738 3541 3484 2280 3557 342 4081 1975 1352 2892 M13302 GO_ONE_CARBON_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ONE_CARBON_METABOLIC_PROCESS.html The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. 29/37 Gene Ontology BP GO:0006730 3.9461947626239e-07 6.58179147542289e-07 2475 2510.72727272727 2739 3.58745042769351e-08 708 1.90266584366374 2.04737648551898 1 12.5804188172361 2475 708 2097 4358 2754 2865 3728 1242 2823 1829 2739 2893 M14375 GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 23/26 Gene Ontology BP GO:2001269 3.31024000502654e-08 1.97691467186943e-07 3100 2607.18181818182 2739 3.00930914075838e-09 525 1.39732200333408 -1.1743917348652 -1 9.99677975245958 3096 2417 3136 3984 525 2456 2813 2057 3241 2739 2215 2894 M15497 GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. 52/80 Gene Ontology BP GO:0042149 2.44204484860994e-07 4.53425166822908e-07 3210 3105 2739 2.22004101789268e-08 1822 1.77167850904321 2.10153412548207 1 12.0159884808311 3209 4156 2729 4220 2462 2667 2739 2174 4070 3907 1822 2895 M13069 GO_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_JNK_CASCADE.html An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. 86/112 Gene Ontology BP GO:0007254 1.48445195469764e-07 3.24978342474009e-07 2670 2763.81818181818 2740 1.34950186805562e-08 1676 1.69369191729304 -1.83345503353293 -1 11.7464904210631 2670 1676 3148 3916 2072 2740 2951 2268 3372 3107 2482 2896 M12244 GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMICAL_HOMEOSTASIS_WITHIN_A_TISSUE.html Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. 12/12 Gene Ontology BP GO:0048875 1.31934239195248e-06 1.78197391865164e-06 2540 2941.54545454545 2742 1.19940289378565e-07 1285 2.89306831633595 2.11755374195797 1 17.8372578682577 4158 2538 1285 2537 3410 3078 2353 4413 4291 1552 2742 2897 M14369 GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. 16/19 Gene Ontology BP GO:0036499 0.000151943869623088 0.000159018179342382 2460 3119.81818181818 2742 1.3814033154664e-05 1625 2.34026308309622 1.4096757129157 1 9.4808534606512 2456 3513 2592 1625 4433 2689 2742 3970 2735 3886 3677 2898 M11202 GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHOLESTEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/16 Gene Ontology BP GO:0032375 1.51480718825857e-07 3.2813770237277e-07 4385 3000 2743 1.51480729151741e-08 228 2.61543285366232 -0.860999133656484 -1 18.1888549078654 4381 2573 4285 2544 2165 4497 4205 2576 228 2803 2743 2899 M11658 GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. 24/35 Gene Ontology BP GO:0046471 3.84810192382799e-07 6.44072598977396e-07 2810 2461.72727272727 2743 3.49827508810362e-08 1147 1.81248894467178 -1.67525116291652 -1 11.9972147376784 1784 2806 2806 3922 2745 1223 1147 2743 2571 3953 1379 2900 M15106 GO_REGULATION_OF_GLUCOSE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_TRANSPORT.html Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 115/138 Gene Ontology BP GO:0010827 1.84314104111244e-07 3.76972978650381e-07 2485 2704.81818181818 2743 1.67558290502657e-08 991 1.88618204458402 1.95091372055164 1 12.9631389264297 2482 3345 2743 2997 2232 1722 991 3151 2630 3440 4020 2901 M15259 GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 8/16 Gene Ontology BP GO:0032372 1.51480718825857e-07 3.2813770237277e-07 2545 3022.18181818182 2744 1.51480729151741e-08 229 2.61543285366232 -0.860999133656484 -1 18.1888549078654 4382 2574 4545 2545 2166 4498 4206 2542 229 2813 2744 2902 M12842 GO_CILIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MORPHOGENESIS.html A process that is carried out at the cellular level and in which the structure of a cilium is organized. 238/309 Gene Ontology BP GO:0060271 3.88308279419151e-08 1.97691467186943e-07 2300 2822.09090909091 2746 3.53007532975399e-09 703 1.53965105881707 1.46058134943744 1 11.0265562125678 2298 2149 3592 3875 703 1886 2746 4221 2589 3668 3316 2903 M13223 GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. 33/44 Gene Ontology BP GO:0030947 5.35567749818711e-07 8.34839778863137e-07 1085 2442.81818181818 2746 4.86879891088461e-08 1081 1.84404455447182 1.94351493038975 1 11.9838295166762 1081 2746 2153 3684 2949 1494 1374 2811 4286 1437 2856 2904 M14883 GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_TYROSINE_AUTOPHOSPHORYLATION.html The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. 33/44 Gene Ontology BP GO:0038083 2.24109975199906e-07 4.28247932076042e-07 3025 3027.63636363636 2747 2.03736361845075e-08 1869 1.76572835576268 -1.60225741581274 -1 12.0225324756081 3023 2744 2747 2457 2392 3550 4194 1869 4140 2711 3477 2905 M12680 GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_CAPPING.html Any process that activates or increases the frequency, rate or extent of telomere capping. 19/20 Gene Ontology BP GO:1904355 2.90732717737118e-07 5.17711188530735e-07 4235 2934.18181818182 2748 2.64302505598011e-08 1418 1.95680311342072 -1.63192696140032 -1 13.161765793206 4235 2464 2748 1642 2572 2995 2725 4457 1418 2914 4106 2906 M13413 GO_CELL_CYCLE_G1_S_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G1_S_PHASE_TRANSITION.html The cell cycle process by which a cell in G1 phase commits to S phase. 121/140 Gene Ontology BP GO:0044843 5.255204408991e-06 6.22992767262042e-06 50 2121.18181818182 2748 4.77746996572146e-07 47 1.48266689096031 1.50205410407263 1 8.21646236012872 47 3020 3666 3185 3899 340 155 1264 3315 2748 1694 2907 M14096 GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. 88/106 Gene Ontology BP GO:0008286 3.9476118790861e-08 1.97691467186943e-07 2260 2702.18181818182 2748 3.58873813629165e-09 720 1.28888567512703 -1.14863549906212 -1 9.21222330452106 2260 1664 3641 3661 720 1244 2748 3842 3498 3877 2569 2908 M10976 GO_ERYTHROCYTE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_HOMEOSTASIS.html Any process of regulating the production and elimination of erythrocytes within an organism. 89/106 Gene Ontology BP GO:0034101 2.34227383971465e-07 4.41417585102967e-07 1755 2686.36363636364 2749 2.12934008099049e-08 1683 1.62061353371718 -1.50882756005316 -1 11.0021692584609 1752 4131 3512 3189 2424 1683 1748 1836 2952 3574 2749 2909 M14407 GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. 121/140 Gene Ontology BP GO:0000082 5.255204408991e-06 6.22992767262042e-06 50 2121.27272727273 2749 4.77746996572146e-07 48 1.48266689096031 1.50205410407263 1 8.21646236012872 48 3021 3667 3186 3900 341 156 1255 3316 2749 1695 2910 M15523 GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. 396/638 Gene Ontology BP GO:0002683 7.51964571230792e-08 2.28689428729205e-07 2865 2355.27272727273 2750 6.83604179030091e-09 292 2.09798535972317 -2.07330721046907 -1 14.9229759814741 2864 1322 426 2750 1434 3353 4390 3233 3131 292 2713 2911 M13249 GO_DNA_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEMETHYLATION.html The removal of a methyl group from one or more nucleotides within an DNA molecule. 11/14 Gene Ontology BP GO:0080111 4.03554459751354e-05 4.3668346540071e-05 1825 2468.54545454545 2751 3.66874420450999e-06 255 1.56361778720642 1.78562221890981 1 7.24414507900494 1825 4059 3145 3621 4282 1339 255 993 2751 4030 854 2912 M15126 GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator. 33/42 Gene Ontology BP GO:1901797 1.10097627268237e-06 1.5260180508761e-06 2405 2861.90909090909 2751 1.0008880215086e-07 2297 1.75316348253204 2.03883827090026 1 10.8920100354866 2401 2751 2714 3470 3322 2433 2302 2297 3171 3272 3348 2913 M13676 GO_REGULATION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE.html Any process that modulates the rate or extent of progression through the cell cycle. 1059/1342 Gene Ontology BP GO:0051726 9.63796534951697e-08 2.53938011162528e-07 1850 2861.81818181818 2752 9.63796576752368e-09 1732 1.66527578961535 1.85674541650125 1 11.7400447495569 1847 3583 4441 4044 1785 1732 1958 2944 2752 4019 2375 2914 M16764 GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that modulates the frequency, rate or extent of response to reactive oxygen species. 37/43 Gene Ontology BP GO:1901031 1.46440568701145e-06 1.95329116979013e-06 2610 2718.63636363636 2752 1.33127878343439e-07 1970 2.39537059045678 2.78190305440626 1 14.6461794103658 2608 3415 2302 2847 3459 2752 1970 2254 2108 3377 2813 2915 M13723 GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SODIUM_ION_TRANSMEMBRANE_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. 27/32 Gene Ontology BP GO:1902307 7.23248533377512e-08 2.25241234530691e-07 4210 2619.63636363636 2754 6.57498688322056e-09 685 1.87426616083299 -1.59285185458453 -1 13.3329470700515 4206 685 2386 1767 1400 3275 2754 3465 2771 1543 4564 2916 M15826 GO_STEROL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_METABOLIC_PROCESS.html The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 122/191 Gene Ontology BP GO:0016125 1.51231753773431e-08 1.97691467186943e-07 2960 2490.90909090909 2754 1.37483413466385e-09 36 2.22414537538472 -2.02690537651077 -1 15.9789964004636 2960 2638 1621 3342 36 2603 3288 2754 2824 2286 3048 2917 M13840 GO_REGULATION_OF_EXOSOMAL_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXOSOMAL_SECRETION.html Any process that modulates the frequency, rate or extent of exosomal secretion. 18/20 Gene Ontology BP GO:1903541 3.9499553140842e-07 6.58514585325468e-07 2845 1988 2755 3.59086911206626e-08 58 1.16269108678503 -1.19508263634523 -1 7.64344571747978 657 2845 3466 3463 2755 211 58 1367 2841 3788 417 2918 M14366 GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_GOLGI_APPARATUS.html A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. 32/34 Gene Ontology BP GO:0034067 9.93048358446909e-07 1.39554636419615e-06 1165 2498.45454545455 2755 9.02771642449943e-08 259 0.923887435485553 -0.847630546204696 -1 5.7251099120642 1164 2755 3899 3514 3273 965 259 1540 4135 4114 1865 2919 M14572 GO_PERICARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PERICARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. 25/30 Gene Ontology BP GO:0060039 1.53355156427252e-06 2.02889264388969e-06 2740 2547.18181818182 2755 1.39413875751332e-07 246 2.4041914909007 3.13016337178521 1 14.6577384713875 2738 2795 2243 1089 3485 2755 3089 4087 246 2650 2842 2920 M12742 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. 72/101 Gene Ontology BP GO:0032088 3.97496043899143e-07 6.62208769159582e-07 1105 2370.45454545455 2757 3.61360105198868e-08 815 1.48112003169749 -1.41341948646302 -1 9.76386498454371 1103 1697 3288 2966 2757 815 1248 4140 3743 3266 1052 2921 M14258 GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. 31/50 Gene Ontology BP GO:1901532 2.53513015399405e-07 4.64590807661848e-07 3155 2799.63636363636 2757 2.30466404193202e-08 936 2.00591516989689 -2.50244324482303 -1 13.5967242225554 3154 2757 2431 3128 2499 3922 4218 936 1880 3333 2538 2922 M10607 GO_INTERMEDIATE_FILAMENT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_ORGANIZATION.html Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. 20/32 Gene Ontology BP GO:0045109 1.00283947163365e-06 1.40803019357615e-06 1095 2399.54545454545 2760 9.11672662513091e-08 904 3.13607317503355 3.49574969773515 1 19.6912112125121 1094 2832 1032 1855 3276 2323 2957 2760 4202 904 3160 2923 M12388 GO_PROTEIN_TARGETING_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MEMBRANE.html The process of directing proteins towards a membrane, usually using signals contained within the protein. 190/285 Gene Ontology BP GO:0006612 3.02898918984464e-07 5.34464302525612e-07 1675 3131.63636363636 2761 2.75362691534543e-08 1672 1.31946984210717 -0.97031213106554 -1 8.81843007153953 1672 4343 4166 2682 2598 2030 2563 3135 3924 4574 2761 2924 M13732 GO_CELLULAR_RESPONSE_TO_ETHANOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ETHANOL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. 26/40 Gene Ontology BP GO:0071361 4.50485180116343e-07 7.27562493259751e-07 4050 2094.27272727273 2761 4.09532065782194e-08 147 2.72273574237629 3.14164974980758 1 17.923563953003 4049 652 955 147 2846 2761 2784 3617 580 920 3726 2925 M16605 GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_ANAPHASE_PROMOTING_COMPLEX_ACTIVITY.html Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex. 14/15 Gene Ontology BP GO:0051488 1.24109537466419e-07 2.90301379182623e-07 2765 2769.36363636364 2761 1.12826858607149e-08 1927 1.60289674483275 1.92914061610209 1 11.1954976075406 2761 2887 2733 2842 1927 2942 2221 3626 3608 2494 2422 2926 M13395 GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EPINEPHRINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system. 18/24 Gene Ontology BP GO:0071872 4.80157565105209e-07 7.64865850884812e-07 1470 2511.54545454545 2762 4.36506972637527e-08 1155 1.94420515654501 2.16335031470926 1 12.7206536730087 1466 3197 2990 3214 2888 1605 1155 1743 4008 2762 2599 2927 M14963 GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis. 19/24 Gene Ontology BP GO:1903672 4.41713491232918e-06 5.28896776815946e-06 1540 2816.27272727273 2763 4.01558525547928e-07 1540 1.75046597345002 2.2166960701694 1 9.85528826924482 1540 3478 2342 2636 3860 2732 2763 2389 3173 2917 3149 2928 M16069 GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that modulates the frequency, rate or extent of the viral entry into the host cell. 30/69 Gene Ontology BP GO:0046596 6.27796122262892e-06 7.36730228723641e-06 3660 2687.90909090909 2763 5.70725376146206e-07 918 2.41306866135969 -2.5669738059441 -1 13.253763780648 3659 2763 1948 1944 3938 3143 2768 3676 918 2295 2515 2929 M11699 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HEAT.html Any process that modulates the frequency, rate or extent of cellular response to heat. 92/95 Gene Ontology BP GO:1900034 4.02176629395968e-07 6.6809277278809e-07 615 2841.54545454545 2764 3.65615184469922e-08 615 0.999431028214274 0.99607273492434 1 6.54754099380942 615 4383 4117 4622 2764 1014 727 2051 4471 4496 1997 2930 M13258 GO_FC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_FC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. 201/363 Gene Ontology BP GO:0038093 6.55400430476116e-07 9.86280143274698e-07 1855 2809 2764 5.95818750660066e-08 1453 1.65001145951527 -1.42521517789337 -1 10.5820521260167 1853 3869 3876 1453 3057 2027 2126 3546 1915 4413 2764 2931 M12668 GO_REGULATION_OF_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of heart morphogenesis. 28/47 Gene Ontology BP GO:2000826 6.05256995937618e-05 6.48609120704223e-05 2695 2839.36363636364 2765 5.50248771106169e-06 1270 1.97968645949665 -1.43463242937996 -1 8.83476783091127 2693 3130 2765 1270 4326 3044 3039 1995 2733 3580 2658 2932 M14388 GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STIMULUS_INVOLVED_IN_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. 18/28 Gene Ontology BP GO:0014874 2.13857179927695e-07 4.14788436099861e-07 3310 2415.90909090909 2765 1.94415637014805e-08 473 2.57140747355652 -1.710848219 -1 17.5983517452995 3309 2839 1745 2306 2357 3082 3631 473 1096 2765 2972 2933 M15627 GO_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 21/45 Gene Ontology BP GO:0050704 1.69461006538531e-05 1.89954724987662e-05 1965 2957.09090909091 2765 1.54056647156616e-06 1961 1.96671412603044 1.57962496689165 1 9.90815537549292 2765 3746 2328 3701 4128 2406 1961 1963 4258 1998 3274 2934 M16328 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. 43/69 Gene Ontology BP GO:0051155 1.19769904152739e-07 2.84948968717509e-07 4420 2617.09090909091 2765 1.0888173697556e-08 514 2.30698679347193 -2.30360934706383 -1 16.1830450026577 4420 514 1772 1618 1896 3775 2765 3492 3535 2058 2943 2935 M10931 GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 50/61 Gene Ontology BP GO:0043647 1.72934297539931e-07 3.60278591263368e-07 4035 2967.81818181818 2766 1.57213010121538e-08 1749 1.48533474790176 -1.53581970924963 -1 10.2157398591226 4034 1749 3021 2766 2189 4040 4459 1908 2420 3828 2232 2936 M13782 GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. 19/24 Gene Ontology BP GO:1901018 4.0395526284792e-07 6.70329471480517e-07 3390 2419 2767 3.67232124564182e-08 780 2.09169703368563 2.39693328829008 1 13.8235951840922 3386 834 1631 1349 2767 3762 4168 3250 1506 780 3176 2937 M10231 GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT.html Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. 10/16 Gene Ontology BP GO:0072216 8.08108972570724e-06 9.37688540990419e-06 2770 2800.18181818182 2768 7.34647219045575e-07 588 2.8024318913411 2.05327188956979 1 15.0937738832204 2768 3558 1955 2525 3984 2239 588 3901 2902 2675 3707 2938 M14111 GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein. 31/58 Gene Ontology BP GO:0042517 2.16837783276473e-06 2.75969968704986e-06 4065 2983.36363636364 2769 1.97125451816171e-07 1478 2.17857292880804 -1.92321135679208 -1 12.9574617546664 4063 3113 1932 2622 3626 4466 3615 2489 2769 1478 2644 2939 M15982 GO_CHROMATIN_SILENCING_AT_RDNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING_AT_RDNA.html Repression of transcription of ribosomal DNA by altering the structure of chromatin. 18/40 Gene Ontology BP GO:0000183 8.70712632603466e-06 1.00681557641748e-05 3080 2677.45454545455 2769 7.9156007155972e-07 563 1.98995782274278 1.71414876764757 1 10.6186926149454 3079 2865 2423 2438 3997 2743 2032 563 3146 2769 3397 2940 M13991 GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that stops or reduces the activity of an enzyme. 818/1178 Gene Ontology BP GO:0043086 3.44486449682083e-08 1.97691467186943e-07 2820 2562.36363636364 2770 3.44486455022275e-09 670 2.07430192865851 2.33028270195707 1 14.8948519605494 2816 1210 4463 2697 670 2319 3453 3203 2770 1194 3391 2941 M15086 GO_MESENCHYMAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESENCHYMAL_CELL_PROLIFERATION.html The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. 17/21 Gene Ontology BP GO:0010463 7.16164439439522e-06 8.35375566987238e-06 2350 2547.09090909091 2770 6.51060700704697e-07 255 3.00286603448607 -1.24507462533283 -1 16.344004683648 2349 3202 1785 2960 4333 2821 2770 255 2174 2598 2771 2942 M13384 GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus. 75/93 Gene Ontology BP GO:0046823 2.59436699893213e-08 1.97691467186943e-07 3615 2342.54545454545 2771 2.35851548138764e-09 221 1.78566373395492 2.18478063684406 1 12.806502414596 3613 221 2771 2162 286 2567 3118 2815 1511 3106 3598 2943 M15509 GO_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. 221/300 Gene Ontology BP GO:0030099 1.07981111004877e-07 2.68108916491833e-07 2740 2725.54545454545 2771 9.81646511862192e-09 1804 1.85409982836046 -1.62090886251105 -1 13.036870562709 2736 2996 2705 2201 1804 2086 3160 3097 3200 2771 3225 2944 M12959 GO_REGULATION_OF_CHEMOKINE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHEMOKINE_SECRETION.html Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell. 13/20 Gene Ontology BP GO:0090196 5.57705632057106e-06 6.59467422099546e-06 4145 2684.36363636364 2772 5.07006405327435e-07 1261 2.96211056558967 -3.3648062704663 -1 16.4489204154576 4143 3235 1261 1574 3908 3606 2772 2138 1798 1752 3341 2945 M13929 GO_PURINE_NUCLEOTIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOTIDE_TRANSPORT.html The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. 12/18 Gene Ontology BP GO:0015865 4.46154070733616e-07 7.21318586213869e-07 2875 2678.09090909091 2772 4.0559469201135e-08 383 1.52644271297063 1.63638949193591 1 10.0049317423329 2874 997 2772 2735 2843 3717 4416 3771 383 2560 2391 2946 M14937 GO_REGULATION_OF_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_ASSEMBLY.html Any process that modulates the frequency, rate or extent of cilium assembly. 56/66 Gene Ontology BP GO:1902017 6.58291202196714e-08 2.17413460714792e-07 3620 2737.81818181818 2772 5.98446565358473e-09 380 1.7117350624556 -1.5136752311349 -1 12.1953219668072 3618 2284 2994 2322 1306 3246 2707 4452 380 4035 2772 2947 M15934 GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION.html The directed movement of the mitochondrion to a specific location. 20/23 Gene Ontology BP GO:0051654 4.05729721364472e-07 6.71800380881133e-07 3680 2874.72727272727 2772 3.68845269263838e-08 860 2.2960515256894 -0.712859866497174 -1 15.1828225125381 3679 3484 2715 2180 2772 4340 2862 2480 860 3686 2564 2948 M16581 GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. 137/177 Gene Ontology BP GO:0034614 1.09672088396871e-07 2.70288255990805e-07 3775 2813.27272727273 2772 9.97019035128445e-09 1819 1.85578049913325 -1.67823331389936 -1 13.0417487669403 3774 2206 2750 2043 1819 3983 3007 2772 3346 3034 2212 2949 M12658 GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. 33/48 Gene Ontology BP GO:0097237 2.80537658945968e-06 3.47812876918622e-06 3250 2768.72727272727 2774 2.55034560618312e-07 1194 2.12626158686553 2.50695168010996 1 12.4130316808768 3247 3958 2299 2449 3726 2774 2101 1194 2236 3546 2926 2950 M14440 GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_CALCIUM_ION_TRANSPORT.html The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion. 12/14 Gene Ontology BP GO:0006851 1.54721273018713e-07 3.32679336116485e-07 3855 2795.81818181818 2774 1.406557126363e-08 216 2.28805409700091 -2.05531778996524 -1 15.8832231267961 3851 2534 2493 2116 2111 4284 3951 2774 216 3500 2924 2951 M11779 GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 31/63 Gene Ontology BP GO:0045979 1.40273640044119e-07 3.12144068448248e-07 2480 2698.18181818182 2775 1.27521499080065e-08 498 1.81617915356798 2.13684892755686 1 12.6384719410736 2480 3110 2604 3203 2034 2449 498 3786 2937 2775 3804 2952 M16203 GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. 28/38 Gene Ontology BP GO:0071549 1.29528417747904e-06 1.75355172470467e-06 665 2093.90909090909 2776 1.17753176372577e-07 153 1.59722555793319 1.49796005749656 1 9.80909791499956 662 2788 2776 2883 3401 741 153 1032 3674 3583 1340 2953 M10912 GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. 28/42 Gene Ontology BP GO:0033006 3.5349233207915e-07 6.02932485764035e-07 2540 2959.72727272727 2777 3.21356717161565e-08 1839 1.44018729844775 -1.28452279045349 -1 9.55420252526484 2536 2777 3263 2600 2688 2543 4299 1839 3696 3312 3004 2954 M13885 GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION_INVOLVED_IN_MEIOTIC_CELL_CYCLE.html A process of chromosome organization that is involved in a meiotic cell cycle. 31/56 Gene Ontology BP GO:0070192 2.57618085130894e-06 3.21867802687601e-06 275 1949.18181818182 2777 2.34198533454476e-07 46 1.50567665035465 1.58607698648302 1 8.81178154531443 271 3705 3472 2924 3695 193 46 431 3726 2777 201 2955 M11941 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. 498/657 Gene Ontology BP GO:1902532 4.87300683700156e-08 2.00124455538996e-07 2750 2615.18181818182 2778 4.43000631358076e-09 985 1.78817230890877 2.07088617868498 1 12.8144005742597 2746 1283 2798 4382 985 2476 2963 2934 2778 2230 3192 2956 M12708 GO_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that modulates the frequency, rate, or extent of mast cell degranulation. 28/42 Gene Ontology BP GO:0043304 3.5349233207915e-07 6.02932485764035e-07 2540 2939.36363636364 2778 3.21356717161565e-08 1603 1.44018729844775 -1.28452279045349 -1 9.55420252526484 2537 2778 3264 2601 2689 2544 4300 1603 3697 3315 3005 2957 M13920 GO_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that modulates the frequency, rate or extent of protein acetylation. 75/101 Gene Ontology BP GO:1901983 2.27224662751311e-06 2.88110271951907e-06 1025 2492.09090909091 2778 2.06568088580208e-07 622 1.56679674757202 1.57638554666835 1 9.25543596247918 1021 3038 3445 2223 3639 725 622 2196 3701 4025 2778 2958 M14058 GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of ATP metabolic process. 31/63 Gene Ontology BP GO:1903580 1.40273640044119e-07 3.12144068448248e-07 2485 2689.81818181818 2778 1.27521499080065e-08 499 1.81617915356798 2.13684892755686 1 12.6384719410736 2481 3111 2605 3204 2035 2450 499 3682 2938 2778 3805 2959 M11588 GO_CREATINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CREATINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. 8/10 Gene Ontology BP GO:0006600 1.05309370035729e-06 1.46751871451406e-06 3785 2555.63636363636 2780 1.05309419941047e-07 28 1.96512237926933 -1.63517939829923 -1 12.2585396665596 3782 2075 4313 1495 3349 3149 3455 2780 28 1519 2167 2960 M15517 GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_INTERFERON_GAMMA.html Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. 29/32 Gene Ontology BP GO:0060330 1.12190837267378e-06 1.55225681179039e-06 1270 2619.09090909091 2781 1.01991722254612e-07 1253 1.27205542379324 -1.19348019625668 -1 7.86179300032748 1268 2781 3607 2453 3330 1622 1253 2804 3925 3425 2342 2961 M12472 GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of smooth muscle cell proliferation. 83/99 Gene Ontology BP GO:0048661 4.19862762860917e-07 6.87652740440636e-07 2620 2995.18181818182 2782 3.81693493627605e-08 2246 1.80116169965265 1.84811331809944 1 11.8662580020528 2619 2246 2402 4047 2805 3277 2624 2782 3911 2499 3735 2962 M12639 GO_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that modulates the frequency, rate or extent of receptor internalization. 42/56 Gene Ontology BP GO:0002090 4.09840173240362e-07 6.76274903506235e-07 3990 2526.90909090909 2782 3.72582045081739e-08 468 2.18962429485113 -1.94146113852702 -1 14.4670087757375 3988 468 1749 1564 2782 3753 4418 896 3112 1935 3131 2963 M11851 GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). 94/127 Gene Ontology BP GO:0043648 8.95374322243465e-08 2.47250843999931e-07 2845 2671.09090909091 2784 8.13976689712868e-09 146 1.92167983078927 -2.10095866808215 -1 13.5891207558749 2844 146 2601 4487 1614 2784 2766 3783 2445 2910 3002 2964 M13807 GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. 83/130 Gene Ontology BP GO:0050728 1.25959359769062e-07 2.92605542189438e-07 4040 2857.27272727273 2784 1.14508515437065e-08 1112 2.3574876515642 -1.98414903300616 -1 16.5104755536147 4039 2660 1112 2784 1940 3476 3645 2585 3176 1683 4330 2965 M13388 GO_AMINO_SUGAR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_METABOLIC_PROCESS.html The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group. 34/46 Gene Ontology BP GO:0006040 4.20010984086171e-08 1.97691467186943e-07 3895 2935 2785 3.81828174640703e-09 789 1.54684367546387 -1.08806892157319 -1 11.0785960949679 2785 2365 2925 4371 789 2290 2741 3893 4078 2157 3891 2966 M15161 GO_STEROL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_TRANSPORT.html The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 46/72 Gene Ontology BP GO:0015918 4.18762907023673e-08 1.97691467186943e-07 4410 2979.45454545455 2786 3.80693559086083e-09 782 2.96185946033268 -2.78757748423313 -1 21.316491238687 4409 2701 840 1727 782 4263 4606 4589 2786 1877 4194 2967 M11810 GO_REGULATION_OF_ORGAN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ORGAN_FORMATION.html Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. 27/52 Gene Ontology BP GO:0003156 7.14345595604231e-06 8.33671947917354e-06 4245 2905.63636363636 2787 6.49407195557357e-07 724 2.88464920063437 -1.76128367369804 -1 15.6988815635153 4244 2787 1678 1663 3961 4255 4409 3413 724 2570 2258 2968 M10706 GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY.html The specification and formation of anisotropic intracellular organization of an epithelial cell. 33/37 Gene Ontology BP GO:0090162 8.43419096449676e-08 2.41354800478496e-07 3500 2760.09090909091 2789 7.66744662530937e-09 1550 1.433404085196 -1.45285932262856 -1 10.1237669022555 3498 1831 3097 2789 1550 3587 2273 2685 2928 2707 3416 2969 M16070 GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS.html The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. 49/57 Gene Ontology BP GO:0006921 6.00388215751484e-08 2.09491454642436e-07 2790 2508.27272727273 2789 5.45807483760275e-09 680 1.86056009545289 -2.04514673931877 -1 13.2978335629987 2860 2300 2873 3358 1220 2716 2789 2796 680 3212 2787 2970 M14719 GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS.html Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. 18/27 Gene Ontology BP GO:2000136 6.0397619982045e-06 7.10210072722909e-06 3185 2771.90909090909 2790 5.49070779955169e-07 1244 2.06160465665131 -1.51816113109705 -1 11.3423022196807 3185 3198 2790 2045 3931 3394 2731 1244 2362 3792 1819 2971 M14920 GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 16/24 Gene Ontology BP GO:0042347 9.24330917453003e-06 1.0654781294605e-05 1430 2263.18181818182 2790 8.40304364596411e-07 452 1.69514086535499 -1.25415785522574 -1 8.98375790254732 1428 2882 3045 3158 4010 1740 1011 2790 452 3887 492 2972 M15712 GO_REGULATION_OF_RECEPTOR_RECYCLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RECEPTOR_RECYCLING.html Any process that modulates the frequency, rate, or extent of receptor recycling. 23/26 Gene Ontology BP GO:0001919 9.6972441219119e-07 1.36897077971044e-06 995 2057.36363636364 2790 8.81568036027535e-08 104 1.50203607716139 -1.04303598877644 -1 9.39206898156468 992 2805 3042 4390 3259 438 104 725 2790 3676 410 2973 M14125 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that activates or increases the frequency, rate or extent of response to wounding. 152/245 Gene Ontology BP GO:1903036 2.36765943267478e-08 1.97691467186943e-07 3415 2357.63636363636 2791 2.15241768923249e-09 213 2.60106213461757 -2.59231677035364 -1 18.7060573281225 3411 1562 297 2069 213 4308 4557 3033 2791 367 3326 2974 M11633 GO_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_SECRETION.html The controlled release of a peptide from a cell or a tissue. 55/82 Gene Ontology BP GO:0002790 1.84185254928212e-08 1.97691467186943e-07 4445 2562.72727272727 2792 1.67441142245656e-09 91 2.33072356756298 -2.08545639502139 -1 16.7501088981446 4444 337 991 1503 91 4260 4495 4471 2792 747 4059 2975 M11082 GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_TRANSMISSION_CHOLINERGIC.html The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine. 10/32 Gene Ontology BP GO:0007271 1.59093849564779e-06 2.09647035407793e-06 4240 2714.27272727273 2793 1.44630876922025e-07 689 3.0145201338724 -2.68767092395732 -1 18.3611722972188 4240 1088 1378 1843 3496 3626 4223 2793 689 2073 4408 2976 M13119 GO_GAS_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GAS_TRANSPORT.html The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 9/23 Gene Ontology BP GO:0015669 4.71358171803395e-06 5.61071776260219e-06 1980 2635.72727272727 2795 4.71359171609748e-07 546 2.74069798364643 -3.35059974903998 -1 15.4185052657875 1980 3564 4408 2795 3898 2538 2843 546 3393 2428 600 2977 M10203 GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOPLASMIC_RETICULUM_TO_CYTOSOL_TRANSPORT.html The directed movement of substances from endoplasmic reticulum to cytosol. 24/32 Gene Ontology BP GO:1903513 1.95050003970458e-06 2.50847890678425e-06 2365 2803.18181818182 2796 1.77318342636579e-07 1351 1.29948561564648 -1.06359744714345 -1 7.7414255174778 2363 3454 3543 3182 3584 2643 1351 2120 1847 3952 2796 2978 M13452 GO_REGULATION_OF_RENAL_SODIUM_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RENAL_SODIUM_EXCRETION.html Any process that modulates the amount of sodium excreted in urine over a unit of time. 13/27 Gene Ontology BP GO:0035813 3.18377836962784e-07 5.55251902319278e-07 3295 2663.54545454545 2796 2.89434439125039e-08 694 2.717314548036 2.41103826766072 1 18.2318821046568 3292 2523 1057 2117 2627 2796 3047 4208 4124 694 2814 2979 M10374 GO_REGULATION_OF_ICOSANOID_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ICOSANOID_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. 20/42 Gene Ontology BP GO:0032303 1.96836246737242e-07 3.93237507536888e-07 2955 2640.36363636364 2797 1.78942058498531e-08 1469 2.20327766649393 2.39647828340499 1 15.1178304124864 2952 1955 1692 2797 2289 3005 2547 3162 3577 1469 3599 2980 M12269 GO_LEUKOCYTE_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MIGRATION.html The movement of a leukocyte within or between different tissues and organs of the body. 241/380 Gene Ontology BP GO:0050900 1.68829643948827e-15 9.58005284504749e-14 2905 2220.72727272727 2797 1.53481494498933e-16 52 2.62163285781566 2.54972469846618 1 36.721152234058 2904 1409 52 451 2061 2797 3412 3994 2947 135 4266 2981 M15426 GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 1709/2257 Gene Ontology BP GO:0031399 5.05428596572042e-08 2.02998167617902e-07 2800 2717.27272727273 2797 5.05428608067654e-09 1131 1.94385725668397 2.13045701720061 1 13.9269268406576 2797 2093 4556 3035 1131 2647 2991 3187 2507 1349 3597 2982 M10092 GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell. 11/22 Gene Ontology BP GO:0050855 4.16323886073607e-07 6.83299838412873e-07 3750 2552.36363636364 2798 3.78476331689074e-08 491 1.90751886295548 -1.90431765773313 -1 12.5793068914794 3748 1026 1859 1034 2798 4180 4540 4496 491 930 2974 2983 M13307 GO_CELL_DIFFERENTIATION_IN_HINDBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DIFFERENTIATION_IN_HINDBRAIN.html The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. 23/41 Gene Ontology BP GO:0021533 5.99386502010475e-08 2.09491454642436e-07 4015 2609.81818181818 2799 5.44896834855152e-09 926 3.38865219567963 -3.12944656134209 -1 24.3123329825504 4014 2799 926 986 1218 3808 4164 4012 1076 1611 4094 2984 M15333 GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UDP_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. 13/14 Gene Ontology BP GO:0006047 1.30756276664295e-06 1.76811669665494e-06 580 2207.36363636364 2799 1.18869413071748e-07 424 1.07317910775978 -1.05033337354284 -1 6.549485078187 577 2922 3400 4121 3406 686 424 608 4230 2799 1108 2985 M14758 GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. 35/55 Gene Ontology BP GO:0060338 3.70349632664066e-06 4.48993444707113e-06 1000 2427.27272727273 2800 3.36682051013505e-07 1000 1.51032948722638 -1.72758158582231 -1 8.60372506290643 1000 3692 3301 3225 3811 1248 1062 2041 2800 3197 1323 2986 M11052 GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. 23/43 Gene Ontology BP GO:0045939 2.13394057145445e-06 2.7225734792919e-06 4085 2644 2801 1.93994785574725e-07 438 2.98589395278712 4.16324017952345 1 17.820017749026 4085 2801 1133 1478 3617 4087 2958 2142 438 2737 3608 2987 M10081 GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION.html The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. 40/66 Gene Ontology BP GO:0060395 4.18680270017787e-07 6.8644090781986e-07 3105 2460.63636363636 2802 3.8061849972411e-08 753 2.56009300401844 2.79795706388761 1 16.9159546126814 3102 2317 1140 753 2802 3094 3402 3705 1188 1464 4100 2988 M10141 GO_DENTATE_GYRUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DENTATE_GYRUS_DEVELOPMENT.html The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. 9/19 Gene Ontology BP GO:0021542 9.79278473563833e-06 1.12424938008698e-05 2675 2639.45454545455 2802 9.79282789029076e-07 399 2.03938897128022 1.64477596078888 1 10.7798188849248 2671 3835 4227 2802 4044 1879 406 399 1787 3897 3087 2989 M10174 GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_GROWTH_OF_SYMBIONT_INVOLVED_IN_INTERACTION_WITH_HOST.html Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism. 8/28 Gene Ontology BP GO:0044144 2.19183302584688e-05 2.42823787363465e-05 1100 2847.18181818182 2802 2.19185464474105e-06 1099 2.09762468849352 -2.09762468849352 -1 10.3337843145113 1099 3570 4230 4133 4196 1927 1250 2005 4482 2802 1625 2990 M10492 GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSPORTER_ACTIVITY.html Any process that stops or reduces the activity of a transporter. 64/102 Gene Ontology BP GO:0032410 2.62932889750765e-08 1.97691467186943e-07 2900 2448.81818181818 2802 2.39029902630186e-09 294 1.68838303648233 1.56603426889465 1 12.1026589727897 2899 299 2802 2906 294 2485 1898 4449 3395 1719 3791 2991 M11000 GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION_INVOLVED_IN_DNA_REPLICATION.html The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. 25/26 Gene Ontology BP GO:0006271 0.000291621494352844 0.000302342872821698 455 2621.54545454545 2802 2.65145597709769e-05 275 0.98336177069555 0.977844705786317 1 3.62205988869171 455 2802 3659 2953 4476 1181 275 2006 4265 3997 2768 2992 M11743 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION.html Any process that modulates the frequency, rate or extent of extracellular matrix organization. 41/44 Gene Ontology BP GO:1903053 6.61903931359794e-08 2.17810395517477e-07 2670 2755 2803 6.01730864794724e-09 1314 1.8179925489805 2.07117570679592 1 12.9578238621255 2668 3079 2371 2463 1314 1956 2803 3754 3822 2991 3084 2993 M12015 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. 34/44 Gene Ontology BP GO:0002832 4.1888849698084e-07 6.86540393255319e-07 2535 2850.63636363636 2803 3.80807797035318e-08 1198 2.28516794054603 -2.0867175791058 -1 15.0870715807491 2534 3694 2626 2597 2803 2595 3256 4084 3139 2831 1198 2994 M11418 GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NICOTINAMIDE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide. 16/21 Gene Ontology BP GO:0019359 4.68595311060148e-07 7.50817487039555e-07 2250 2676.36363636364 2804 4.25995828063619e-08 997 1.96918934037567 -2.30927577950986 -1 12.9026847988344 2247 2877 2428 4091 2869 2804 3580 4007 2039 1501 997 2995 M10123 GO_SINGLE_FERTILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_FERTILIZATION.html The union of male and female gametes to form a zygote. 76/166 Gene Ontology BP GO:0007338 2.18367697849543e-06 2.77765144366846e-06 2805 2900.36363636364 2805 1.98516285997592e-07 2383 1.93041068679131 -1.74548271973767 -1 11.4627217510161 2805 3359 2632 2383 3628 2475 2795 2568 2827 3464 2968 2996 M14049 GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. 1524/2035 Gene Ontology BP GO:0051247 5.3677704454551e-08 2.05087954115883e-07 3280 2710.63636363636 2805 5.36777057511341e-09 1014 2.00793071451418 2.22106997260441 1 14.3800753914021 3277 2096 4471 2091 1203 3286 3292 2805 2374 1014 3908 2997 M14145 GO_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT.html Any process that modulates the frequency, rate or extent of protein import. 242/325 Gene Ontology BP GO:1904589 1.31138146753294e-07 3.00411010867397e-07 3050 2744.45454545455 2805 1.19216504154736e-08 1451 1.86162695069872 2.01152138825907 1 12.9909956599472 3047 2993 2805 1451 1972 2356 2469 3478 2186 3566 3866 2998 M16385 GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. 16/21 Gene Ontology BP GO:0019363 4.68595311060148e-07 7.50817487039555e-07 2250 2679 2805 4.25995828063619e-08 998 1.96918934037567 -2.30927577950986 -1 12.9026847988344 2248 2878 2429 4092 2870 2805 3581 4017 2040 1511 998 2999 M11813 GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response. 8/23 Gene Ontology BP GO:0016056 1.21729580300662e-07 2.87618259237356e-07 1905 2625.90909090909 2806 1.21729586968803e-08 1623 1.98886137972285 2.24218394445852 1 13.9271721726731 1905 2954 4326 3369 1992 1623 1727 3330 3220 2806 1633 3000 M15865 GO_GERM_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GERM_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. 195/412 Gene Ontology BP GO:0007281 6.24891006217456e-08 2.12948256567067e-07 1630 2489.81818181818 2806 5.6808274906086e-09 1252 1.91557106538653 1.88618849717169 1 13.6796588272886 1629 4100 2953 3123 1252 2032 1647 2806 1944 3044 2858 3001 M16318 GO_MITOTIC_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_SISTER_CHROMATID_COHESION.html The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. 12/13 Gene Ontology BP GO:0007064 3.91248223974206e-07 6.53437898834165e-07 1565 2762.63636363636 2810 3.55680266867135e-08 1277 1.21651935607494 1.23682950487927 1 8.00695758437613 1565 2932 3325 3157 2751 1964 1277 4337 3704 2567 2810 3002 M15432 GO_NEUTROPHIL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTROPHIL_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a neutrophil. 20/36 Gene Ontology BP GO:0002446 0.000141066272152402 0.000147900262353566 1010 2550.63636363636 2812 1.28250289345037e-05 906 1.45316379361729 -1.42954178146281 -1 5.8935404510213 1010 4237 3328 3942 4424 1229 906 962 2812 4085 1122 3003 M15770 GO_CELL_KILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_KILLING.html Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. 42/141 Gene Ontology BP GO:0001906 3.33941134790183e-07 5.75491888955083e-07 2970 2862.09090909091 2813 3.03582895890541e-08 1936 2.14397195359359 -1.95692773503059 -1 14.3251858335842 2966 3077 2100 2772 2657 2971 3476 4011 2813 1936 2704 3004 M15516 GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_SECRETION.html Any process that modulates the frequency, rate or extent of interferon-gamma secretion. 8/15 Gene Ontology BP GO:1902713 4.04966937664405e-07 6.71367632148241e-07 1640 2785.09090909091 2814 4.04967011463622e-08 82 1.89516443369137 1.73121539386709 1 12.5127505681473 1636 3569 4562 4154 2841 1112 82 2740 4416 2814 2710 3005 M10996 GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus. 43/51 Gene Ontology BP GO:1900077 8.62634511467031e-06 9.98218945997536e-06 3575 2940.72727272727 2815 7.8421626721129e-07 2202 1.89401797099482 2.34924696050053 1 10.1089039213684 3575 2313 2769 2202 3994 3027 2555 3612 2815 2372 3114 3006 M11647 GO_SKELETAL_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CONTRACTION.html A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. 30/55 Gene Ontology BP GO:0003009 2.89603271832254e-07 5.1629272943888e-07 4010 3027.36363636364 2818 2.63275736322739e-08 683 1.9430114966145 -1.75155941319006 -1 13.0707027050816 4006 3114 2320 2359 2569 4293 4587 2818 683 2291 4261 3007 M11204 GO_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_PROLIFERATION.html The expansion of a B cell population by cell division. Follows B cell activation. 19/53 Gene Ontology BP GO:0042100 5.07488576601153e-07 7.99101301835928e-07 3705 2846.81818181818 2819 4.6135335787904e-08 1563 2.31288141336456 -1.78137964433382 -1 15.1068278092957 3704 2819 1563 1634 2921 3540 2760 2539 4288 2050 3497 3008 M11898 GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH.html Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. 25/28 Gene Ontology BP GO:1903205 8.88126549381799e-07 1.27466157750571e-06 2680 2835.36363636364 2819 8.07388098102962e-08 1185 1.88839816682658 2.54934593646298 1 11.9002180376844 2677 3146 2819 2451 3211 3413 4049 1185 2636 3586 2016 3009 M13351 GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLOOD_COAGULATION_INTRINSIC_PATHWAY.html A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. 10/24 Gene Ontology BP GO:0007597 1.32984234577629e-07 3.0243188831364e-07 2710 2990.81818181818 2820 1.20894766014707e-08 1967 2.20117292172345 2.19018094909406 1 15.3741611707116 2708 3557 1967 4492 1987 2820 3161 3981 2748 2080 3398 3010 M11206 GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. 203/249 Gene Ontology BP GO:0051054 5.13183172903879e-07 8.06703143081672e-07 1120 2538.90909090909 2821 4.66530266010574e-08 581 1.56655564458941 1.5715244584696 1 10.1886761610511 1119 4099 3837 3009 2926 883 581 1992 2380 4281 2821 3011 M10335 GO_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_AMMONIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus. 53/89 Gene Ontology BP GO:0060359 2.10080371524425e-07 4.10371103569752e-07 3925 2973.36363636364 2824 1.90982174168389e-08 380 2.03656526118553 2.0763178246103 1 13.9246629397541 3925 380 1917 2824 2339 4339 4629 4032 2559 1383 4380 3012 M15527 GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of JUN kinase activity. 87/121 Gene Ontology BP GO:0043507 2.28118779386238e-07 4.33770609106728e-07 4460 3217.18181818182 2825 2.07380730036325e-08 1816 1.80508421985664 -1.92678836024147 -1 12.2821795068578 4460 2655 2801 1816 2401 4491 3669 4037 2316 2825 3918 3013 M11757 GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of phospholipid metabolic process. 79/120 Gene Ontology BP GO:1903725 1.09539654217135e-07 2.70248150091373e-07 2955 2654.72727272727 2826 9.95815087919977e-09 1668 2.03310201305155 2.26941071059568 1 14.2988477122824 2954 3033 2050 1668 1817 2962 2197 4137 2014 2826 3544 3014 M11394 GO_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 74/100 Gene Ontology BP GO:0005976 5.83943098068585e-08 2.0762333639785e-07 2605 3133 2827 5.30857375971011e-09 1192 1.30459811082434 1.43621336099934 1 9.29593255556266 2603 4392 3880 4554 1192 2169 2329 2422 3762 4333 2827 3015 M13454 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. 155/259 Gene Ontology BP GO:0031348 1.5651220693887e-07 3.35290653262689e-07 2375 2791 2827 1.42283834612226e-08 1658 2.01459950098849 -1.64157416008833 -1 13.9640553279279 2373 3612 1658 3436 2119 2069 2827 3929 3851 1778 3049 3016 M15490 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_RENIN_ANGIOTENSIN.html The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. 17/41 Gene Ontology BP GO:0003081 8.56398547192933e-08 2.43720026916741e-07 3900 2896.72727272727 2827 7.78544164118309e-09 1562 1.98670043515019 -1.83121987117753 -1 14.0661326826653 3899 2485 2122 3633 1562 3546 3935 2827 2132 2600 3123 3017 M15470 GO_CELLULAR_RESPONSE_TO_PEPTIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PEPTIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. 294/401 Gene Ontology BP GO:1901653 3.73875779260854e-08 1.97691467186943e-07 3995 2881.27272727273 2828 3.39887077831482e-09 658 1.70216150074204 -1.52102806284136 -1 12.2023486538807 3994 1386 2813 1951 658 3686 4573 2828 2511 3249 4045 3018 M16081 GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening. 57/60 Gene Ontology BP GO:1904356 3.32617265066825e-06 4.06639026367823e-06 1385 2869 2828 3.02379789046201e-07 754 1.29614726811498 1.35683133211121 1 7.42777214087496 1383 4152 3964 3578 3778 1659 754 2575 2449 4439 2828 3019 M13509 GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 1102/1576 Gene Ontology BP GO:0044092 3.81820991850944e-08 1.97691467186943e-07 2820 2648.45454545455 2829 3.8182099841137e-09 788 1.98861105103809 2.24389701424878 1 14.2748629616758 2820 1168 4431 3592 788 2096 3081 3541 2829 1485 3302 3020 M10560 GO_REGULATION_OF_PROSTAGLANDIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROSTAGLANDIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell. 13/18 Gene Ontology BP GO:0032306 1.71874228442813e-07 3.58302323003767e-07 3955 3041.27272727273 2830 1.56249310791298e-08 1750 2.06827643687754 -2.27128219452523 -1 14.2747778335012 3951 2526 2051 2154 2188 3598 2830 4092 4047 1750 4267 3021 M10972 GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. 21/28 Gene Ontology BP GO:0033032 2.13264737318901e-07 4.14071062027877e-07 3260 2738.18181818182 2830 1.93877052720428e-08 1713 1.76262308083607 1.76479040815118 1 12.0290023684043 3260 2830 2844 2218 2354 2997 2691 1713 3337 3507 2369 3022 M12770 GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE.html The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. 20/22 Gene Ontology BP GO:0061029 5.29336290856864e-07 8.27065735848553e-07 4370 2882.72727272727 2831 4.81214925653763e-08 1478 2.62031229184502 2.72562224241851 1 17.0876338869337 4366 2831 1478 2419 2942 4066 3421 3535 2580 2251 1821 3023 M13178 GO_REGULATION_OF_RESPONSE_TO_WOUNDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_WOUNDING.html Any process that modulates the frequency, rate or extent of response to wounding. 411/603 Gene Ontology BP GO:1903034 1.00198541142688e-15 6.0548547004796e-14 4135 2626.54545454545 2831 9.10895828569895e-17 48 2.5625121006188 -2.52850319642884 -1 36.4415724439138 4133 2127 48 1460 580 4584 4553 4363 2831 125 4088 3024 M11737 GO_SINGLE_ORGANISM_MEMBRANE_BUDDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_MEMBRANE_BUDDING.html A membrane budding which involves only one organism. 109/124 Gene Ontology BP GO:1902591 1.88682280828866e-08 1.97691467186943e-07 3500 2677.72727272727 2832 1.71529347679176e-09 99 2.00206197719432 -1.26457710860225 -1 14.372182845345 3497 1624 2682 2179 99 3312 2832 4316 835 3958 4121 3025 M13425 GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_GASTROINTESTINAL_EPITHELIUM.html Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. 19/41 Gene Ontology BP GO:0030277 2.9503059439272e-06 3.6384239483417e-06 2890 2706.27272727273 2832 2.68209990948815e-07 887 3.55587842798923 4.2266876840945 1 20.7600281244968 2887 2458 887 2832 3744 2465 2058 4018 2883 1667 3870 3026 M11977 GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLY_A_MRNA_EXPORT_FROM_NUCLEUS.html The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. 13/17 Gene Ontology BP GO:0016973 0.000310145218714753 0.000321475986339885 2510 2954.09090909091 2833 2.81989954635535e-05 931 1.24415444844139 -1.55765145806645 -1 4.57686102196247 2507 4297 3385 2596 4477 2833 3133 2241 1966 4129 931 3027 M12127 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that activates, maintains or increases the rate of a response to an external stimulus. 281/449 Gene Ontology BP GO:0032103 3.50373047017366e-08 1.97691467186943e-07 4250 2726.27272727273 2833 3.1852095690675e-09 540 2.20764516152247 -2.07172766241461 -1 15.8596143687032 4249 2142 540 1893 589 4199 4130 4488 2833 564 4362 3028 M12454 GO_SPHINGOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPHINGOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds. 11/13 Gene Ontology BP GO:0046519 1.91139421599479e-05 2.13278592014958e-05 3450 2614.90909090909 2833 1.73764620244273e-06 93 1.76123855193428 -2.23389491429551 -1 8.76556503661233 3446 2545 2833 1207 4150 3887 4079 1323 93 3740 1461 3029 M12237 GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. 64/95 Gene Ontology BP GO:0032024 8.68618829107602e-08 2.45384890956523e-07 3315 2631.54545454545 2836 7.89653512184542e-09 1573 2.22494940045907 2.70004977240394 1 15.7594339642163 3313 3045 1895 3102 1573 3549 3542 2836 1608 1929 2555 3030 M10415 GO_SKELETAL_MUSCLE_TISSUE_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_TISSUE_REGENERATION.html The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. 30/42 Gene Ontology BP GO:0043403 4.70011207274129e-08 1.98252330758246e-07 4045 2732.72727272727 2837 4.27282924832288e-09 676 1.99492186103001 2.26198374389121 1 14.3178738328167 4044 676 2382 2837 950 3928 3600 3239 1544 2287 4573 3031 M13467 GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 23/35 Gene Ontology BP GO:0043949 1.6830522663733e-07 3.5291762935714e-07 2950 2928.63636363636 2837 1.5300476319371e-08 972 2.58360098619985 2.50246899941915 1 17.8779473951957 2950 3985 2358 4357 2175 2837 2752 2733 972 3675 3421 3032 M14189 GO_DRUG_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DRUG_TRANSPORT.html The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 33/52 Gene Ontology BP GO:0015893 1.47633296153149e-07 3.2341700894567e-07 4100 2899.36363636364 2837 1.34212096418396e-08 1890 2.35476229321695 -2.60093584754304 -1 16.3807600104824 3507 3103 1890 2262 2071 4098 4096 2431 2837 2995 2603 3033 M15146 GO_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_ORGANIZATION.html A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. 973/1375 Gene Ontology BP GO:0061024 3.28403357890741e-08 1.97691467186943e-07 3105 2815.54545454545 2837 3.28403362743935e-09 622 1.83716183638641 -1.55621036311558 -1 13.1791005003784 3105 2592 4537 2522 622 2260 2837 3638 1764 4013 3081 3034 M15797 GO_ADENOHYPOPHYSIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADENOHYPOPHYSIS_DEVELOPMENT.html The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. 6/17 Gene Ontology BP GO:0021984 4.0185318466721e-07 6.67793881520189e-07 4305 2506.90909090909 2838 4.01853257335921e-08 220 3.12611265087779 -2.91550143073569 -1 20.7213186240054 4301 1118 4573 220 2838 4212 3853 472 863 1473 3653 3035 M10136 GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. 239/337 Gene Ontology BP GO:0046394 5.77956015411893e-08 2.07580109259326e-07 3680 2691.72727272727 2839 5.25414573268379e-09 564 2.29333216834174 2.19870986510416 1 16.4271100090097 3676 1426 564 3853 1179 4324 4143 2839 2401 855 4349 3036 M12329 GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VENTRICULAR_CARDIAC_MUSCLE_CELL_ACTION_POTENTIAL.html Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. 17/22 Gene Ontology BP GO:0098911 5.84603154204801e-08 2.0762333639785e-07 2960 2257.63636363636 2839 5.31457427035805e-09 761 2.52468409829295 3.15582381277956 1 18.0954439550221 2957 866 1251 1701 1194 2839 2998 4384 3016 761 2867 3037 M10201 GO_INORGANIC_ION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_ION_IMPORT_INTO_CELL.html The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 17/26 Gene Ontology BP GO:0099587 5.48374243618315e-07 8.51095849084729e-07 2570 2874.63636363636 2840 4.98522163915169e-08 1973 2.61350794886117 -2.23369440280356 -1 17.0078839530974 2569 3494 1990 4101 2961 2840 3090 4364 1973 2124 2115 3038 M11326 GO_DEVELOPMENTAL_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEVELOPMENTAL_INDUCTION.html A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). 21/39 Gene Ontology BP GO:0031128 7.33430108587325e-05 7.82717957627712e-05 4110 2972.54545454545 2841 6.66776873295574e-06 1265 2.3496275712799 -1.8134262569104 -1 10.299865322867 4106 3476 2306 1265 4347 3694 2579 4165 1766 2841 2153 3039 M12093 GO_INORGANIC_CATION_IMPORT_INTO_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_INORGANIC_CATION_IMPORT_INTO_CELL.html The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. 17/26 Gene Ontology BP GO:0098659 5.48374243618315e-07 8.51095849084729e-07 2570 2880.72727272727 2841 4.98522163915169e-08 1974 2.61350794886117 -2.23369440280356 -1 17.0078839530974 2570 3495 1991 4102 2962 2841 3091 4419 1974 2127 2116 3040 M15405 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACETYLATION.html Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation. 20/38 Gene Ontology BP GO:1901984 8.2573592586799e-06 9.57187160703477e-06 2050 2839.27272727273 2841 7.50671841051074e-07 1210 1.26714712366953 0.741595196333229 1 6.75061529123767 2047 3755 3651 3792 3987 1210 1323 1697 2572 4357 2841 3041 M15803 GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response. 9/33 Gene Ontology BP GO:0002825 6.57254024205469e-07 9.87791658471591e-07 2845 2831.09090909091 2841 6.57254218597832e-08 593 2.55661337722993 -3.44363540230118 -1 16.4566873875618 2841 2951 4574 2303 3106 4041 4310 593 1302 2438 2683 3042 M11631 GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION.html Any process that activates or increases the rate of neuroblast proliferation. 24/33 Gene Ontology BP GO:0002052 1.96521092607297e-06 2.52530418089409e-06 2380 2798.81818181818 2842 1.78655698323113e-07 1803 1.7133387760073 1.95418539958486 1 10.2375232862479 2380 2409 2842 1803 3587 3055 3714 1980 2796 3214 3007 3043 M16528 GO_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCONEOGENESIS.html Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. 46/84 Gene Ontology BP GO:0006111 0.000104063935946446 0.00010987281460377 2845 2760.72727272727 2842 9.46080533479935e-06 1081 1.97611311471756 2.60020004658185 1 8.33043028406797 2842 3679 3074 4168 4391 2151 1081 1211 2543 3413 1815 3044 M10528 GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SODIUM_ION_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 15/20 Gene Ontology BP GO:0010766 1.53113293111486e-06 2.02637867297383e-06 4030 2618.18181818182 2844 1.39193999703431e-07 713 1.83377670591097 1.82075554946744 1 11.1542981977547 4028 946 2172 2844 3483 3128 1846 713 4151 977 4512 3045 M16119 GO_VITAMIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VITAMIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. 126/185 Gene Ontology BP GO:0006766 5.83183411480139e-08 2.0762333639785e-07 3765 2199.18181818182 2844 5.30166751763057e-09 29 2.35758304961545 -2.32723643111827 -1 16.8902767800839 3763 29 1121 3022 1188 3138 3650 2844 1198 872 3366 3046 M13141 GO_PROTEIN_KINASE_C_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_KINASE_C_SIGNALING.html A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. 12/19 Gene Ontology BP GO:0070528 1.35222892046492e-06 1.81900004825767e-06 3220 2901.09090909091 2847 1.22929977419316e-07 1047 1.39924770116347 -1.27776845602422 -1 8.5551987856516 3217 1047 2847 2817 3427 3223 3543 2402 4457 2556 2376 3047 M13682 GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INOSITOL_PHOSPHATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. 4/19 Gene Ontology BP GO:0010919 3.24691412396027e-06 3.97471492206976e-06 3565 2943.90909090909 2848 3.24691886807312e-07 479 5.04057201934208 -4.39083404967984 -1 29.2663753238113 3561 2090 4444 2100 3802 4111 4285 479 2848 2216 2447 3048 M14569 GO_REGULATION_OF_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_ORGANIZATION.html Any process that modulates the frequency, rate or extent of chromatin organization. 180/225 Gene Ontology BP GO:1902275 2.4296201165944e-06 3.05954598173579e-06 1845 3089.45454545455 2848 2.20874799982261e-07 1844 1.65465498398983 1.81310298426181 1 9.73417205115116 1844 4105 3820 2680 3665 2625 2286 2283 3500 4328 2848 3049 M15232 GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. 1133/1532 Gene Ontology BP GO:0051248 3.66740461795988e-08 1.97691467186943e-07 2705 2880.63636363636 2848 3.66740467848424e-09 746 2.00052381625432 2.21856382512497 1 14.36105397273 2704 3291 4543 3620 746 2381 2906 2456 2834 2848 3358 3050 M12491 GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. 28/41 Gene Ontology BP GO:0035710 4.03766859094413e-05 4.36811717127715e-05 1735 2931.54545454545 2850 3.67067517848867e-06 1735 1.68524357080225 -1.95675776580016 -1 7.81619519386495 1735 3125 3223 2466 4283 2443 2850 2471 3862 3039 2750 3051 M10787 GO_KERATINOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATINOCYTE_PROLIFERATION.html The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. 18/25 Gene Ontology BP GO:0043616 1.63221185608678e-06 2.1447844581677e-06 2735 2645.36363636364 2851 1.48383006095423e-07 755 3.34344988453239 3.45017297375966 1 20.3412902049469 2733 2851 755 3409 3508 3234 4155 1315 3820 888 2431 3052 M11758 GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport. 122/154 Gene Ontology BP GO:1903650 1.85708705804205e-08 1.97691467186943e-07 3195 2639.90909090909 2852 1.68826097610754e-09 94 1.77993478183985 2.15526855236325 1 12.7650524098224 3195 1615 3154 2942 94 2635 2800 2852 2440 3641 3671 3053 M14087 GO_RESPONSE_TO_VITAMIN_A http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_VITAMIN_A.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. 18/32 Gene Ontology BP GO:0033189 5.15708376431606e-06 6.11828423135203e-06 4555 3280.09090909091 2852 4.68826895747751e-07 2093 2.19484075906439 1.87170219172241 1 12.2360276735652 4554 2852 2093 2152 3895 4514 4501 2566 2740 2324 3890 3054 M11409 GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. 1731/2411 Gene Ontology BP GO:0009891 8.43028967226341e-08 2.41354800478496e-07 1700 2859.81818181818 2853 8.43028999207744e-09 1654 1.85357024091212 1.97329029027261 1 13.1244448570389 1698 3579 4297 4535 1654 1752 1693 2902 2853 3688 2807 3055 M11748 GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. 18/22 Gene Ontology BP GO:0006206 1.86233639894561e-07 3.79398041343867e-07 3850 2676.36363636364 2853 1.69303323326862e-08 928 1.55654627459486 -0.77169474785362 -1 10.6732118711683 3850 2853 3088 3396 2242 2271 928 2360 1499 3481 3472 3056 M10844 GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 277/312 Gene Ontology BP GO:0034976 2.36435646351513e-08 1.97691467186943e-07 1970 2875.09090909091 2854 2.14941498993186e-09 211 1.38496123163244 -1.19113946103726 -1 9.90734733345053 1966 4633 4124 4615 211 1685 1616 2854 3006 4539 2377 3057 M12036 GO_ASYMMETRIC_CELL_DIVISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASYMMETRIC_CELL_DIVISION.html The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. 18/19 Gene Ontology BP GO:0008356 4.92233119638427e-07 7.80095608200818e-07 2160 2649.09090909091 2854 4.47484754338041e-08 772 1.30354103866211 1.03932779333176 1 8.47956632326167 2158 2850 3098 2854 2902 1571 772 3589 2871 3786 2689 3058 M11342 GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS.html An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. 109/351 Gene Ontology BP GO:0002460 3.89764968895879e-07 6.51569123288857e-07 3475 2886.63636363636 2855 3.54331852680869e-08 1432 2.11971648218852 -2.19444416393661 -1 14.0384868740171 3475 2217 1486 2855 2748 4207 4216 3192 3404 1432 2521 3059 M16543 GO_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEURAL_TUBE_PATTERNING.html The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. 35/52 Gene Ontology BP GO:0021532 3.10789788558549e-08 1.97691467186943e-07 2990 2178.18181818182 2855 2.82536175408197e-09 449 2.03284401193878 2.38014169300091 1 14.5948964344045 2988 560 2312 841 449 2855 3245 3744 594 2938 3434 3060 M13768 GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 69/88 Gene Ontology BP GO:0072527 3.99139043762447e-07 6.6423246445875e-07 2430 3030.90909090909 2856 3.62853741979091e-08 1634 1.63002504197056 1.9373512220216 1 10.7545182740082 2430 2264 3129 3860 2760 3801 4601 2538 1634 2856 3467 3061 M10369 GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of osteoclast differentiation. 79/137 Gene Ontology BP GO:0045670 4.62980008166081e-07 7.4464084963594e-07 2045 2802 2857 4.20891005089227e-08 1165 2.32726378794662 -2.33758012761384 -1 15.2784658609536 2044 3037 1165 4161 2857 2651 3488 3627 3654 1577 2561 3062 M13924 GO_CELLULAR_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 43/54 Gene Ontology BP GO:0034605 5.61871180326521e-07 8.69433522467344e-07 3250 2853.54545454545 2858 5.1079211256929e-08 1608 1.98185934963684 1.58715068379088 1 12.8501787063805 3246 2319 2858 1608 2970 2314 2075 4254 2518 3169 4058 3063 M13973 GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT.html Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. 35/45 Gene Ontology BP GO:0061036 8.36986155234144e-07 1.20872022976551e-06 3935 2784.45454545455 2859 7.60896794240211e-08 1186 2.24889796122818 -1.66801374218894 -1 14.249579767949 3935 1828 1972 1599 3188 3685 4407 3831 2139 1186 2859 3064 M10751 GO_ACTIN_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. 506/646 Gene Ontology BP GO:0030029 1.72073552579416e-08 1.97691467186943e-07 3020 2177.54545454545 2861 1.72073553911834e-09 101 2.13875237791885 2.43080875067681 1 15.3611626183871 3016 1249 4259 354 101 3508 3702 2861 1125 201 3577 3065 M13620 GO_REGULATION_OF_LIPID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 108/167 Gene Ontology BP GO:0032368 9.88212510754908e-08 2.57167383251823e-07 3695 2659 2863 8.98375050131077e-09 991 2.33775991413402 3.05599689352507 1 16.5128228091912 3695 1628 1026 1794 1723 3800 3640 4583 2863 991 3506 3066 M16430 GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. 68/80 Gene Ontology BP GO:0043525 2.74225640199501e-08 1.97691467186943e-07 2715 2847.81818181818 2863 2.49296039652427e-09 335 1.72496103497776 2.5189881840674 1 12.3673074079293 2713 4147 3179 3824 335 2973 2278 2100 2612 4302 2863 3067 M16491 GO_PROTEIN_TARGETING_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_LYSOSOME.html The process of directing proteins towards the lysosome using signals contained within the protein. 24/25 Gene Ontology BP GO:0006622 4.61955767952561e-07 7.43250410886331e-07 2935 3114.63636363636 2863 4.19959877230921e-08 2481 1.05265186392431 -1.11882489222114 -1 6.84963004486101 2934 2807 3620 2979 2856 2818 2688 2863 4464 3751 2481 3068 M10408 GO_AXO_DENDRITIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXO_DENDRITIC_TRANSPORT.html The directed movement of organelles or molecules along microtubules in neuron projections. 39/46 Gene Ontology BP GO:0008088 1.17438049674052e-06 1.61096475569977e-06 2090 2513.54545454545 2864 1.06761920330567e-07 416 1.39784359906902 -0.940240240803206 -1 8.62607387699129 2087 3392 3252 2864 3356 1016 416 3318 2100 3297 2551 3069 M14198 GO_T_CELL_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_MIGRATION.html The movement of a T cell within or between different tissues and organs of the body. 16/27 Gene Ontology BP GO:0072678 1.32910362928832e-06 1.79360778344877e-06 3090 2299 2864 1.20827675659184e-07 228 2.22388965964141 1.61432417203221 1 13.6784834657039 3089 910 1670 228 3412 3061 4071 758 1391 2864 3835 3070 M10659 GO_LIPOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOPROTEIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. 120/162 Gene Ontology BP GO:0042157 3.1032219501337e-08 1.97691467186943e-07 3490 2719.72727272727 2866 2.82111090355125e-09 446 1.9077918092144 -1.51391076520849 -1 13.690121128946 3488 2212 2866 3296 446 1831 2093 4331 2130 3287 3937 3071 M11354 GO_HYPEROSMOTIC_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYPEROSMOTIC_RESPONSE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. 22/43 Gene Ontology BP GO:0006972 1.04612563149309e-07 2.64657043934525e-07 3865 2707.54545454545 2866 9.51023346579619e-09 802 1.65769590993797 -1.49726143412353 -1 11.6539689884971 3862 802 2472 2115 1771 3530 3058 3429 4080 1798 2866 3072 M12191 GO_DNA_CONFORMATION_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CONFORMATION_CHANGE.html A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. 234/419 Gene Ontology BP GO:0071103 1.92942088278569e-06 2.4848035891508e-06 485 2468.54545454545 2866 1.75402052264382e-07 485 1.71129517571327 1.63407948850032 1 10.2381456269031 485 3865 3558 3753 3580 887 1216 1834 3127 2866 1983 3073 M13567 GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. 9/12 Gene Ontology BP GO:0008655 4.25248984447346e-07 6.93308123521039e-07 4395 2808.09090909091 2866 4.25249065823882e-08 828 1.68841634516349 -0.996011639807381 -1 11.1099176004477 4394 1095 4437 3329 2866 3857 2653 1898 828 2430 3102 3074 M10894 GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process. 45/59 Gene Ontology BP GO:2000378 4.45384215554891e-08 1.97691467186943e-07 3665 2829.81818181818 2867 4.04894749610524e-09 869 1.74065885930788 -1.69317665786826 -1 12.480884006293 3663 2306 2882 1996 869 3460 3796 4494 2578 2867 2217 3075 M14337 GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_SALVAGE.html Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. 9/12 Gene Ontology BP GO:0043097 4.25248984447346e-07 6.93308123521039e-07 4395 2829 2867 4.25249065823882e-08 829 1.68841634516349 -0.996011639807381 -1 11.1099176004477 4395 1096 4488 3330 2867 3858 2654 2067 829 2432 3103 3076 M12131 GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. 18/20 Gene Ontology BP GO:2000647 0.000128983615334323 0.000135537660828954 3340 2791 2868 1.17264707386041e-05 1036 2.26940118039181 -1.44287399122362 -1 9.3602965652333 3339 3187 1994 2868 4415 3126 4162 1936 1036 2759 1879 3077 M12923 GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of Rac protein signal transduction. 19/20 Gene Ontology BP GO:0035020 3.57386932363594e-07 6.08237526074543e-07 4365 3242.72727272727 2869 3.24897264018742e-08 1982 1.94583454846867 1.49742911407332 1 12.9403852472841 4365 1982 2560 2869 2698 4489 4398 3000 2662 2505 4142 3078 M15900 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT1_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein. 15/20 Gene Ontology BP GO:0042510 7.55048259511135e-07 1.10702955970865e-06 3325 2810.63636363636 2869 6.86407744224234e-08 1617 1.99028795935687 -2.08570176784427 -1 12.6799376604497 3323 2869 2295 1617 3140 3155 3520 1790 2717 2198 4293 3079 M13469 GO_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASTROCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. 45/70 Gene Ontology BP GO:0048708 3.14457883386552e-07 5.5006486142768e-07 4585 3219.90909090909 2870 2.8587084393975e-08 1087 2.15993809259466 2.35154366049649 1 14.4784556157834 4585 2710 2124 1087 2620 4397 4433 3228 2745 2870 4620 3080 M14334 GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ANTIBIOTIC.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. 23/32 Gene Ontology BP GO:0071236 0.000152236147796837 0.000159288238295184 2870 2913.27272727273 2870 1.38406075720332e-05 1496 2.43342092272856 2.97167389740384 1 9.86082037164785 2870 3996 2406 2460 4434 2949 2549 1496 2086 3896 2904 3081 M14751 GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. 13/19 Gene Ontology BP GO:0071071 1.44277593044213e-07 3.18767160700249e-07 1835 2496 2870 1.31161456823676e-08 530 1.45943083796516 1.65924764889423 1 10.1193452893459 1834 2924 2870 3421 2050 1375 530 2920 4133 3238 2161 3082 M11232 GO_REGULATION_OF_RUFFLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RUFFLE_ASSEMBLY.html Any process that modulates the frequency, rate or extent of ruffle assembly. 27/35 Gene Ontology BP GO:1900027 4.72007303456708e-07 7.55763930827276e-07 2935 2506.81818181818 2872 4.29097640659388e-08 668 1.58463426525389 1.56542553546159 1 10.3560078475721 2932 668 2644 1587 2872 3147 3655 3068 1445 2207 3350 3083 M14320 GO_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 29/38 Gene Ontology BP GO:0070741 1.81437637464118e-07 3.72563692462728e-07 2190 2610 2873 1.64943320388711e-08 1521 1.63176249810865 -1.48093939478895 -1 11.2083361287843 2188 3117 2898 2873 2223 2150 2349 1521 3230 3148 3013 3084 M15704 GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. 245/343 Gene Ontology BP GO:0043123 1.58154064289461e-07 3.37466835750567e-07 2630 3020.63636363636 2873 1.43776432417159e-08 2128 1.79016084911975 -1.59672086232508 -1 12.3903465203322 2628 3315 2862 3929 2128 2462 3351 3986 2757 2873 2936 3085 M16903 GO_PIGMENT_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_METABOLIC_PROCESS.html The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. 52/73 Gene Ontology BP GO:0042440 4.12083658923714e-08 1.97691467186943e-07 2595 2293.63636363636 2873 3.7462151512953e-09 264 1.77015154302052 -1.53304433955655 -1 12.6942689074266 2594 1750 2929 1525 762 2978 3241 2887 264 3427 2873 3086 M11043 GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of glia cell differentiation. 33/45 Gene Ontology BP GO:0045687 3.18096394525025e-06 3.90013840243727e-06 4520 2831.81818181818 2874 2.89178958599284e-07 976 2.59054944657257 3.16783124258126 1 15.0091743962638 4516 2741 1474 1778 3767 3414 2874 4016 976 2034 3560 3087 M11705 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 165/207 Gene Ontology BP GO:1903828 4.7635925878815e-08 1.98252330758246e-07 2570 3007.90909090909 2874 4.33053881002374e-09 971 1.55553148087027 -1.28173432323132 -1 11.1393884075894 2567 2620 3675 4398 971 2645 3021 4147 2874 3799 2370 3088 M12935 GO_LEFT_RIGHT_AXIS_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_AXIS_SPECIFICATION.html The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). 16/20 Gene Ontology BP GO:0070986 1.12563278976598e-05 1.2852930971242e-05 3895 2858.72727272727 2874 1.0233077719288e-06 385 1.99644768535862 1.95481377113914 1 10.4251890018068 3891 2874 2476 1432 4051 2859 2018 4636 385 3254 3570 3089 M15665 GO_ASPARTATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. 10/12 Gene Ontology BP GO:0006531 7.45611865667035e-07 1.09823742036996e-06 2475 2370.72727272727 2875 6.77829198514378e-08 798 1.93877131587074 -2.27604090218069 -1 12.3560484219846 2472 2946 2916 2875 3127 1343 798 1176 3919 3209 1297 3090 M16497 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 692/874 Gene Ontology BP GO:0031400 4.99058010959512e-08 2.02079099099266e-07 2730 2925.72727272727 2875 4.99058022167162e-09 1117 1.81935518178938 2.07731202602771 1 13.0315471090414 2728 3297 4626 3477 1117 2248 3278 2875 2619 3573 2345 3091 M11859 GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 28/35 Gene Ontology BP GO:0090200 1.04620860122487e-05 1.19665895317092e-05 2570 2905.72727272727 2876 9.51103251360312e-07 1602 2.2952453097015 2.28851902014713 1 12.0792667403289 2566 4475 2514 2923 4043 2244 1750 2992 1602 3978 2876 3092 M14057 GO_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION.html The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. 30/73 Gene Ontology BP GO:0030101 1.12448337348262e-07 2.74557763766229e-07 4360 3211.90909090909 2877 1.02225766450747e-08 1838 1.69750526642243 -1.63535586319187 -1 11.9073326829254 4357 2370 2421 2791 1838 4440 3803 3772 2877 2637 4025 3093 M15238 GO_COENZYME_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 16/22 Gene Ontology BP GO:0009109 1.24410487248681e-05 1.41605185217249e-05 2320 2716.45454545455 2879 1.1310108254392e-06 644 1.720437374658 -1.60748043309672 -1 8.89013693950148 2319 2879 2734 3373 4067 1242 644 4031 2126 3260 3206 3094 M10072 GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PLANAR_POLARITY.html Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. 120/138 Gene Ontology BP GO:0090175 3.15768677236973e-08 1.97691467186943e-07 2470 2783.36363636364 2880 2.87062437972035e-09 462 1.48988474142066 1.8488356442283 1 10.6664879047498 2467 3022 3676 2044 462 3883 4050 2204 2274 3655 2880 3095 M13083 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus. 37/42 Gene Ontology BP GO:0032105 5.93450116693791e-07 9.07459767291438e-07 3825 2848.81818181818 2880 5.39500251615501e-08 1446 2.08360843021539 -1.27752014415282 -1 13.4739105735501 3821 1808 2233 2880 2998 4034 4230 2884 1446 2537 2466 3096 M14517 GO_CELLULAR_RESPONSE_TO_CALCIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CALCIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. 63/108 Gene Ontology BP GO:0071277 1.87186248459408e-07 3.80672034126585e-07 4145 2597.54545454545 2880 1.7016933126008e-08 297 2.47409904324392 -2.54791727423467 -1 17.0276373257798 4141 297 752 1903 2246 3465 2880 4431 3110 1073 4275 3097 M12552 GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 129/187 Gene Ontology BP GO:0042990 2.07830771753246e-07 4.07516469013002e-07 2540 2949.45454545455 2881 1.88937083078834e-08 1801 1.66875755466167 -1.36463995497673 -1 11.3948755113025 2538 3618 3383 3813 2330 1801 3176 2677 2881 4056 2171 3098 M16460 GO_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERAD_PATHWAY.html Any process that modulates the frequency, rate or extent of ERAD pathway. 36/37 Gene Ontology BP GO:1904292 1.42206937652954e-07 3.15540715736382e-07 3805 2968.90909090909 2881 1.29279042586493e-08 1551 1.35334034577583 -1.0996807154139 -1 9.38197073986886 3804 2739 3554 2630 2041 2881 2926 4132 1551 3893 2507 3099 M14041 GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. 24/47 Gene Ontology BP GO:1903020 1.32734748832127e-07 3.02159875888399e-07 2660 2775.63636363636 2882 1.2066796076413e-08 1016 1.22622599267672 -1.05196252827074 -1 8.51503758847057 2656 3453 3533 3722 1984 1668 1016 4202 3854 2882 1562 3100 M11739 GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPONGIOTROPHOBLAST_LAYER_DEVELOPMENT.html The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. 13/21 Gene Ontology BP GO:0060712 0.000143170368034745 0.000150004891345568 3555 2821.27272727273 2883 1.30163350949766e-05 1308 2.60770366789512 1.59956308441663 1 10.6485495909797 3555 4563 2855 2008 4426 2988 1629 1308 1588 3231 2883 3101 M15070 GO_MOTILE_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MOTILE_CILIUM_ASSEMBLY.html The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function. 33/57 Gene Ontology BP GO:0044458 5.89261211211149e-07 9.03425876026017e-07 2715 2981.36363636364 2883 5.35692153674972e-08 2184 1.9567742059677 2.36200461396419 1 12.6509229612361 2883 3102 2184 3912 2994 2750 2357 4300 2711 2712 2890 3102 M14676 GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DELAYED_RECTIFIER_POTASSIUM_CHANNEL_ACTIVITY.html Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity. 11/23 Gene Ontology BP GO:1902259 2.82317123883928e-05 3.09378609852076e-05 1440 2670.90909090909 2885 2.56655224373421e-06 750 2.01961681159788 -2.01153781996366 -1 9.71598320312964 1437 2940 2856 2885 4226 1517 750 3656 3773 2343 2997 3103 M10241 GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 18/21 Gene Ontology BP GO:0051532 1.496686342629e-06 1.99030624528515e-06 2865 2962.63636363636 2886 1.36062487349419e-07 1365 1.27729457872252 -1.11292779944885 -1 7.74582138099762 2863 3500 3668 2672 3466 2568 2227 1365 3212 4162 2886 3104 M11976 GO_DEFENSE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE.html Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. 968/1913 Gene Ontology BP GO:0006952 9.98820255251033e-12 2.70204107423434e-10 2750 2610 2888 9.98820255255522e-13 79 2.31690069259357 -2.247393741712 -1 23.8121902589759 2747 1182 4336 2686 1551 3317 3946 3071 2888 79 2907 3105 M12291 GO_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by the detection of a hormone. 142/264 Gene Ontology BP GO:0009755 1.2989433619621e-07 2.98468319170846e-07 4570 3116.63636363636 2889 1.18085767150496e-08 1963 1.91944162857904 -1.81958215757285 -1 13.4037930555566 4567 3339 2889 2804 1963 3978 4060 2476 2038 3543 2626 3106 M14878 GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. 162/266 Gene Ontology BP GO:0050866 8.89347312894712e-08 2.46385893090484e-07 3950 2745.54545454545 2889 8.08497589860426e-09 348 2.2427247283408 -2.20917123625033 -1 15.8819617475625 3949 2177 453 1897 1607 4253 4435 4559 2889 348 3634 3107 M16854 GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_PHOSPHATASE_TYPE_2A_ACTIVITY.html Any process that modulates the activity of the enzyme protein phosphatase type 2A. 23/25 Gene Ontology BP GO:0034047 1.90635719474923e-06 2.45714128176404e-06 2520 2986.90909090909 2889 1.73305349696301e-07 506 1.26543292867777 1.65880652549681 1 7.54786413886311 2517 4220 3697 3774 3578 2825 2889 2445 506 4313 2092 3108 M14130 GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANION_TRANSMEMBRANE_TRANSPORT.html Any process that modulates the frequency, rate or extent of anion transmembrane transport. 32/44 Gene Ontology BP GO:1903959 5.14736001742096e-07 8.08597777213359e-07 4625 2994.63636363636 2890 4.6794192925035e-08 1860 2.06292940807724 -2.26834492884119 -1 13.4505947375438 4623 3427 2830 2423 2928 3923 1860 2525 2368 2890 3144 3109 M15344 GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_IONOTROPIC_GLUTAMATE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. 17/31 Gene Ontology BP GO:0035235 4.2652896862046e-06 5.11900771470467e-06 2975 2854.54545454545 2891 3.87754359603125e-07 1672 1.8932554990768 2.11803764940179 1 10.6974163170161 2975 2457 1845 3322 3852 1672 2891 4602 2425 1703 3656 3110 M13564 GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY.html Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. 192/252 Gene Ontology BP GO:0010952 4.4808192831449e-08 1.97691467186943e-07 2895 2627 2894 4.07347215855215e-09 885 2.00341356850711 -1.63255534757299 -1 14.3819618529613 2894 3322 1814 2208 885 3268 3254 2554 3062 2656 2980 3111 M14071 GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_IONIZING_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. 72/90 Gene Ontology BP GO:0071479 2.92926105321203e-06 3.61342833525864e-06 2585 2901.09090909091 2894 2.66296813952594e-07 1118 1.97130315647189 2.14433144508441 1 11.4648874639055 2585 3646 2894 4009 3743 2812 1883 1118 3613 2657 2952 3112 M10852 GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT.html The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. 15/16 Gene Ontology BP GO:0099514 1.52026942877824e-06 2.01361049020926e-06 590 2266.09090909091 2895 1.38206407212128e-07 79 0.896972809822195 -0.930503807904987 -1 5.40088927488503 590 2895 3581 3958 3479 641 79 752 4423 3813 716 3113 M12980 GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a symbiont organism effects a change in the structure or processes of its host organism. 52/81 Gene Ontology BP GO:0044003 4.87264205748178e-07 7.74119465399828e-07 2440 2823.90909090909 2895 4.42967557881187e-08 1375 1.4632427171443 1.78810922634029 1 9.537559873277 2438 3064 3545 3769 2895 2775 2923 1375 2684 3426 2169 3114 M11261 GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTEROGRADE_SYNAPTIC_VESICLE_TRANSPORT.html The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. 15/16 Gene Ontology BP GO:0048490 1.52026942877824e-06 2.01361049020926e-06 595 2280.18181818182 2896 1.38206407212128e-07 80 0.896972809822195 -0.930503807904987 -1 5.40088927488503 591 2896 3582 3959 3480 642 80 895 4424 3816 717 3115 M11643 GO_PEPTIDYL_CYSTEINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_CYSTEINE_MODIFICATION.html The modification of peptidyl-cysteine. 19/37 Gene Ontology BP GO:0018198 1.56041177266073e-05 1.75797337074687e-05 1900 2778.90909090909 2896 1.41856621857206e-06 1033 2.16776546287516 -2.00654027531898 -1 11.0112946265271 1898 3487 2495 2896 4107 2079 1033 3448 3915 3606 1604 3116 M12871 GO_PROTEIN_LOCALIZATION_TO_CHROMATIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMATIN.html Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. 16/19 Gene Ontology BP GO:0071168 8.57194680840696e-06 9.92170858196955e-06 4115 3321.36363636364 2896 7.79270927982158e-07 1971 2.28140387610166 1.54365240242506 1 12.2061214020181 4111 2498 2151 1971 3993 4428 4477 2896 2618 2862 4530 3117 M11922 GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. 15/16 Gene Ontology BP GO:0099517 1.52026942877824e-06 2.01361049020926e-06 595 2263.72727272727 2897 1.38206407212128e-07 81 0.896972809822195 -0.930503807904987 -1 5.40088927488503 592 2897 3583 3960 3481 643 81 704 4425 3817 718 3118 M15561 GO_PEPTIDYL_LYSINE_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_TRIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. 26/28 Gene Ontology BP GO:0018023 2.05721934752031e-06 2.63480363997028e-06 1235 2820.45454545455 2897 1.87020115566185e-07 1233 1.964121942935 -2.26785168524945 -1 11.7134778629558 1233 3984 2897 4158 3600 1807 1747 2611 3471 3136 2381 3119 M16090 GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_RELEASE_FROM_HOST_CELL.html Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell. 22/32 Gene Ontology BP GO:1902187 1.30481489136127e-05 1.48222905220172e-05 2900 2999.27272727273 2897 1.1862023911385e-06 2189 1.83918290124179 -1.8868808938486 -1 9.47217222202942 2897 2826 2760 3153 4074 2706 3459 3348 2286 3294 2189 3120 M14655 GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLETHANOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. 15/19 Gene Ontology BP GO:0006646 8.87249008154603e-07 1.2737950123244e-06 880 2206.54545454545 2899 8.06590332707179e-08 144 1.48841863840333 -1.6591920887399 -1 9.35616535023564 879 3515 2899 3899 3210 810 144 1356 3868 3126 566 3121 M13080 GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade. 11/18 Gene Ontology BP GO:2000258 1.78497377057937e-06 2.31737805650273e-06 3885 2803.63636363636 2900 1.62270474438413e-07 906 2.89092301067244 -2.6626982993601 -1 17.4679718193117 3885 2554 1883 2356 3553 4038 3924 1770 3071 2900 906 3122 M11329 GO_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. 983/1254 Gene Ontology BP GO:0051338 5.47170547195317e-08 2.05617623085131e-07 3005 2882.72727272727 2901 5.47170560668118e-09 1223 1.90385863028587 2.07617551389243 1 13.6265851162804 3002 2104 4293 3384 1223 2335 2901 3407 2563 2616 3882 3123 M12996 GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS.html The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. 14/15 Gene Ontology BP GO:0019184 0.000239921611709885 0.000249353419541232 1955 2653.81818181818 2901 2.18134345839471e-05 1133 1.39130549763338 -1.59922145438137 -1 5.2972307216658 1954 2901 2943 3355 4464 1684 1133 1268 4414 2953 2123 3124 M10425 GO_B_CELL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_HOMEOSTASIS.html The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. 24/28 Gene Ontology BP GO:0001782 8.68578786908872e-08 2.45384890956523e-07 4100 2925.90909090909 2902 7.89617110182825e-09 1572 1.87259623690633 -1.98100808648884 -1 13.2457872548546 4099 3980 2902 1814 1572 4072 3339 1879 2119 3516 2893 3125 M13290 GO_REGULATION_OF_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_TRANSPORT.html Any process that modulates the frequency, rate or extent of fatty acid transport. 33/57 Gene Ontology BP GO:2000191 1.67812148917762e-07 3.52042348473556e-07 3350 2994.81818181818 2902 1.52556510652891e-08 2036 1.97631718544944 2.23349033553386 1 13.6513940498128 3349 2749 2417 2902 2173 3354 2677 3736 3764 2036 3786 3126 M15869 GO_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of sprouting angiogenesis. 36/46 Gene Ontology BP GO:1903670 2.28441112411415e-06 2.89342263405584e-06 2680 3093.18181818182 2902 2.07673954198054e-07 2337 1.60272303532281 1.77117639686077 1 9.46704889687413 2680 2337 2525 2642 3643 2902 2873 3950 3453 3032 3988 3127 M14207 GO_GOLGI_TO_VACUOLE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_TO_VACUOLE_TRANSPORT.html The directed movement of substances from the Golgi to the vacuole. 37/38 Gene Ontology BP GO:0006896 6.78401568251474e-07 1.01531119236864e-06 350 2017.36363636364 2903 6.16728888587657e-08 36 1.13324922811978 -1.09634741286352 -1 7.21706072709987 346 3094 3891 3478 3073 171 36 695 2903 4337 167 3128 M14715 GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity. 11/44 Gene Ontology BP GO:0002710 4.99393341982359e-06 5.93077391588544e-06 2300 2754.63636363636 2903 4.53994977812486e-07 486 1.83036492439777 -2.15038577158252 -1 10.2120325042243 2300 2936 2516 2584 3891 3391 3842 486 4569 2903 883 3129 M15017 GO_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION.html Any process in which a protein is transported to, or maintained in, a specific location. 1841/2309 Gene Ontology BP GO:0008104 3.15452359618003e-08 1.97691467186943e-07 2905 2875.81818181818 2903 3.15452364095961e-09 577 1.68014925246703 -1.4676003309087 -1 12.0430860561579 2903 2972 4530 4122 577 1707 3055 2888 2168 4438 2274 3130 M10760 GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_COMMUNICATION.html Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. 1554/2178 Gene Ontology BP GO:0010647 2.2142830902534e-08 1.97691467186943e-07 2905 2300.72727272727 2905 2.21428311231712e-09 155 2.13599411662913 2.33642073604398 1 15.341206099057 2905 1142 4260 892 889 2957 3275 3147 2077 155 3609 3131 M16499 GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. 11/16 Gene Ontology BP GO:0002903 2.2947746561567e-06 2.90467531966733e-06 1210 2456.54545454545 2905 2.08616095435667e-07 968 1.54167825496124 1.68540824613935 1 9.09935393967541 1208 3258 3014 3926 3646 1477 1064 1334 4222 2905 968 3132 M10343 GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. 66/89 Gene Ontology BP GO:1904035 1.22672602093963e-07 2.88718066536779e-07 3965 2778.72727272727 2907 1.11520553576565e-08 948 2.65684498917144 2.52575767044579 1 18.6380172114541 3964 2678 948 1514 1917 3839 3736 3338 2907 1688 4037 3133 M10594 GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 281/347 Gene Ontology BP GO:0033673 3.97658282828809e-08 1.97691467186943e-07 3560 2853.18181818182 2907 3.61507536378757e-09 731 1.79092054665874 2.08662840352318 1 12.8445364053312 3559 2143 2469 2907 731 3619 4286 3781 3030 2660 2200 3134 M10295 GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. 17/24 Gene Ontology BP GO:0009084 2.86755047615e-06 3.54388110638139e-06 2780 2812.72727272727 2908 2.60686746710361e-07 359 2.44009681966653 1.73762649448298 1 14.2404636545135 2777 2004 2213 2508 3736 2908 3097 3150 359 3693 4495 3135 M11133 GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 20/125 Gene Ontology BP GO:0048385 2.55657475360085e-06 3.1952034188839e-06 2375 2798.09090909091 2908 2.32416156777147e-07 239 2.01566306547807 -2.60814429593514 -1 11.8416350872419 2375 3482 2660 2908 3693 1889 3435 2111 4074 3913 239 3136 M13693 GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_INTERNALIZATION.html Any process that activates or increases the frequency, rate or extent of receptor internalization. 20/32 Gene Ontology BP GO:0002092 4.99496841144148e-07 7.89456114756698e-07 3060 2899.81818181818 2910 4.54088140501776e-08 1760 2.52683751087649 1.88337314960941 1 16.5291487745402 3056 2817 1767 2300 2910 3436 3383 1760 3667 2253 4549 3137 M12785 GO_PEPTIDYL_THREONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_THREONINE_MODIFICATION.html The modification of peptidyl-threonine. 79/87 Gene Ontology BP GO:0018210 2.06964570165286e-07 4.06160331075106e-07 2915 2817.09090909091 2911 1.88149626941309e-08 2031 1.67714202622514 2.12981176915557 1 11.4553162385014 2911 2251 3041 2031 2329 2923 2567 3596 2942 2604 3793 3138 M11001 GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. 19/22 Gene Ontology BP GO:0042219 1.33612849086363e-06 1.8025531655519e-06 3135 2608.90909090909 2912 1.21466300212432e-07 830 1.88847382387796 -1.80767946010399 -1 11.5939791142631 3133 856 2337 2501 3416 2525 3004 3827 830 2912 3357 3139 M12196 GO_BASE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_BASE_EXCISION_REPAIR.html In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. 41/43 Gene Ontology BP GO:0006284 1.30984127465396e-05 1.48723559076741e-05 925 2267.18181818182 2913 1.19077188480304e-06 626 1.75196103184524 1.9607660901403 1 9.01482904978485 925 3684 2913 3499 4076 626 631 751 3216 3658 960 3140 M14915 GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. 108/123 Gene Ontology BP GO:1904029 4.41292759439705e-07 7.14452056253635e-07 1875 2735.27272727273 2914 4.01175316325085e-08 1379 1.84266545214285 1.92184852730546 1 12.1092759455689 1872 3348 3083 2652 2837 2035 1379 2914 3578 3394 2996 3141 M14436 GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_ENTRY_INTO_HOST_CELL.html Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. 22/59 Gene Ontology BP GO:0046597 4.14827059172987e-05 4.48568511813133e-05 3260 3055.45454545455 2916 3.77122619332128e-06 2397 2.17029295509328 -2.21433582215578 -1 10.0713997312807 3259 3161 2397 2913 4285 3270 3501 2867 2456 2585 2916 3142 M11051 GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type peptidase activity. 4/15 Gene Ontology BP GO:1902571 1.66854138497829e-06 2.18547823502406e-06 1525 2483.36363636364 2917 1.66854263779328e-07 61 2.23048216863168 -2.23048216863168 -1 13.5127832189738 1522 2967 4276 1992 4328 1864 2917 141 4163 3086 61 3143 M11683 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_PEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity. 4/12 Gene Ontology BP GO:1902572 1.58415920950682e-06 2.08871997785073e-06 1525 2488.09090909091 2918 1.58416033881013e-07 62 2.23048216863168 -2.23048216863168 -1 13.560123981619 1523 2968 4320 1993 4329 1865 2918 139 4164 3088 62 3144 M12080 GO_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. 108/163 Gene Ontology BP GO:0042752 1.65844543063269e-07 3.49332122622631e-07 2800 2798.09090909091 2918 1.50767777786615e-08 1849 1.81807160493539 2.08265188097219 1 12.5558438522405 2799 3347 2976 3130 2162 2383 2133 2918 1849 3108 3974 3145 M16773 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. 13/23 Gene Ontology BP GO:0014857 1.37332839548393e-07 3.09148380463799e-07 3730 2911.90909090909 2918 1.24848043746601e-08 1520 2.27954994690924 2.47199914939278 1 15.9021465617082 3728 2918 2159 3126 2010 3846 3265 2604 1520 2278 4577 3146 M11236 GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CALCIUM_ION_DEPENDENT_EXOCYTOSIS.html Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis. 15/18 Gene Ontology BP GO:0045955 1.09857923781401e-06 1.52314934253534e-06 3090 2741.45454545455 2919 9.98708896722319e-08 286 1.9791389977713 -1.71929694186094 -1 12.3122683240779 3088 2894 2919 1659 3321 4227 4600 881 286 4037 2244 3147 M12119 GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 139/217 Gene Ontology BP GO:0046890 4.19390143299835e-08 1.97691467186943e-07 3180 2817.27272727273 2919 3.81263773904316e-09 785 2.10491611350789 -1.79574091594084 -1 15.1163511252583 3177 3016 1713 3077 785 2919 3897 4054 2843 2854 2655 3148 M13174 GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity. 4/12 Gene Ontology BP GO:1900004 1.74825524472912e-06 2.27605810121001e-06 1525 2497.81818181818 2919 1.74825662010902e-07 63 2.23048216863168 -2.23048216863168 -1 13.4703276575137 1524 2969 4414 1994 4330 1866 2919 142 4165 3090 63 3149 M15052 GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SERINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity. 4/15 Gene Ontology BP GO:1900003 1.57442504955535e-06 2.07706259018458e-06 1525 2509.18181818182 2920 1.57442616502286e-07 64 2.23048216863168 -2.23048216863168 -1 13.5659750266679 1525 2970 4534 1995 4331 1867 2920 138 4166 3091 64 3150 M15939 GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_VENTRICULAR_TRABECULA_MYOCARDIUM_MORPHOGENESIS.html The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. 12/15 Gene Ontology BP GO:0003222 1.12200991103621e-05 1.28147081886389e-05 3360 2678.63636363636 2920 1.02001421216197e-06 123 2.55418179934167 3.12182767295549 1 13.372764495008 3357 2920 1920 2568 4050 3201 2814 1288 123 3503 3721 3151 M16769 GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY.html Any process that modulates the frequency, rate or extent of tight junction assembly. 19/24 Gene Ontology BP GO:2000810 1.78686902803786e-06 2.31919151672528e-06 4605 2930.18181818182 2920 1.62442770850737e-07 1181 2.43285687906704 2.50878340936088 1 14.6813631406387 4601 3179 2058 2138 3554 3981 2088 3749 1181 2920 2783 3152 M12832 GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway. 37/61 Gene Ontology BP GO:0034123 9.94029574825307e-07 1.39650350593664e-06 2440 2471.90909090909 2921 9.0366365814508e-08 1105 2.15295530163454 -2.3591192498781 -1 13.4911145946454 2436 3086 1679 2921 3274 3107 3619 1105 3278 1174 1512 3153 M15771 GO_CELL_CYCLE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_CHECKPOINT.html A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. 230/269 Gene Ontology BP GO:0000075 2.52617376932031e-07 4.63679942747433e-07 3180 2687.27272727273 2922 2.29652187217363e-08 1395 1.64695265164061 1.73557402998156 1 11.1448391827931 1921 3599 3435 3177 2494 1395 1778 3178 2515 2922 3146 3154 M11547 GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. 625/771 Gene Ontology BP GO:0010638 1.43861796649735e-07 3.18301920975377e-07 2425 3035.45454545455 2924 1.43861805963033e-08 2130 1.74678555173391 1.88396466965296 1 12.1352585022789 2425 3300 4309 2668 2130 2890 2979 2924 2336 4282 3147 3155 M12846 GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MODIFIED_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. 51/60 Gene Ontology BP GO:0042398 9.17215717801183e-08 2.49206886189644e-07 3315 2971.36363636364 2924 8.33832505492179e-09 1645 1.68805705417955 -1.68695458438973 -1 11.9170777204875 3315 1758 2744 4353 1645 2698 2496 3635 3036 2924 4081 3156 M15838 GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. 23/27 Gene Ontology BP GO:0033598 1.72989525367153e-06 2.25594243703297e-06 3740 2650.45454545455 2925 1.57263328537944e-07 282 2.54967317558667 -2.23712557208371 -1 15.4247793493881 3736 2422 1686 282 3538 3718 2925 3238 822 2365 4423 3157 M13132 GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. 241/319 Gene Ontology BP GO:0043523 4.94296422925368e-08 2.01774734543894e-07 3010 2337.36363636364 2926 4.49360394573846e-09 996 2.07677703947949 2.39003134070822 1 14.8928594403996 3007 3316 1822 1256 996 2926 2988 1884 1118 3033 3365 3158 M13021 GO_LYSOSOME_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYSOSOME_LOCALIZATION.html Any process in which a lysosome is transported to, and/or maintained in, a specific location. 25/47 Gene Ontology BP GO:0032418 5.1370294950514e-07 8.07247492079506e-07 3645 2821.90909090909 2927 4.67002790414097e-08 1354 1.85365646549439 -1.85480705357393 -1 12.0760841408795 3214 1900 2322 3641 2927 3306 3641 1354 2890 3304 2542 3159 M14363 GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 12/12 Gene Ontology BP GO:1900102 3.07245160223919e-06 3.77704552317541e-06 1370 2306.63636363636 2927 2.79314172103451e-07 316 1.1599821615158 -1.39669534738316 -1 6.675707241009 1366 2927 3462 3458 3756 1386 532 1129 3967 3074 316 3160 M14195 GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT.html The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. 6/12 Gene Ontology BP GO:0043369 7.04977095656831e-07 1.04834082009947e-06 2000 2938.72727272727 2928 7.04977319303648e-08 1539 2.07176824932762 -2.19922969404948 -1 13.2565655115456 2000 3574 4480 3447 3153 1952 1539 2719 4283 2928 2251 3161 M15536 GO_MYELIN_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELIN_MAINTENANCE.html The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. 12/14 Gene Ontology BP GO:0043217 2.6605262600382e-06 3.3171030782309e-06 3700 2797.36363636364 2928 2.41866316136198e-07 1061 1.66753138003252 1.52022707005143 1 9.7476313701463 3696 2928 2831 1773 3703 2970 1061 4620 1203 3076 2910 3162 M11257 GO_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOOD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. 13/27 Gene Ontology BP GO:0032094 8.23285599262803e-07 1.19226513954865e-06 2545 2881.63636363636 2929 7.48441733957728e-08 1647 1.46784970752088 -1.56891495101059 -1 9.27081397836873 2541 2929 3281 1647 3178 2143 2231 3952 3921 3229 2646 3163 M16612 GO_REGULATION_OF_GONADOTROPIN_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GONADOTROPIN_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. 6/14 Gene Ontology BP GO:0032276 3.91083432256541e-06 4.71794454314152e-06 4200 2735.63636363636 2929 3.91084120516374e-07 638 5.63373160008635 6.20447480657209 1 32.2710203522983 4197 2583 4640 1372 3854 4381 3124 903 638 2929 1471 3164 M10523 GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. 15/19 Gene Ontology BP GO:0048715 2.72378515757445e-06 3.38780335156213e-06 3700 2924.81818181818 2930 2.47617139077778e-07 807 1.94685782314825 -1.60898022216012 -1 11.3801472704318 3700 2891 2758 870 3711 4503 4001 2930 807 3812 2190 3165 M11482 GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE.html The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. 68/77 Gene Ontology BP GO:0072384 5.36478586938382e-07 8.35699653506626e-07 2930 2847.81818181818 2931 4.87707925237113e-08 1720 1.44103461950255 -1.11703811824234 -1 9.33939013802745 2930 3041 3645 2931 2951 2385 1720 2905 3037 3825 1956 3166 M12366 GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION.html The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. 3/14 Gene Ontology BP GO:0021520 3.60734025275799e-06 4.38135061239439e-06 1190 2376.54545454545 2932 3.60734610857804e-07 59 1.06304163314478 1.06304163314478 1 6.03441395555917 1190 2971 4364 2932 4379 1196 59 198 4287 3621 945 3167 M14213 GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 90/160 Gene Ontology BP GO:0042035 3.46361933734496e-06 4.21669826705026e-06 2330 2754.81818181818 2935 3.14874980943977e-07 1374 2.11314109226562 -2.1036241700094 -1 12.1450200646199 2327 3634 1834 2935 3797 2954 4053 1374 3638 1653 2104 3168 M12896 GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. 226/332 Gene Ontology BP GO:0043903 5.24121764228748e-07 8.20893621762114e-07 1415 2637.63636363636 2937 4.76474444630976e-08 1358 1.60923700185234 -1.71954608471065 -1 10.4561990420212 1414 3600 3696 3720 2937 1562 1677 2146 3183 3721 1358 3169 M14911 GO_REGULATION_OF_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of neuron death. 312/401 Gene Ontology BP GO:1901214 6.85739842951626e-08 2.20507296091218e-07 3740 2875.36363636364 2938 6.23399876660119e-09 1352 2.03298051178312 2.29759736476975 1 14.4918088760254 3740 3309 2177 1660 1352 3859 3699 2938 1513 2838 4544 3170 M12194 GO_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPIDERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. 137/235 Gene Ontology BP GO:0009913 6.93044676754921e-08 2.20943360292963e-07 4490 2574.18181818182 2939 6.30040635079306e-09 323 2.76259793538754 -2.53672332485415 -1 19.7308132321454 4488 2197 323 2076 1364 3537 2939 3484 3114 471 4323 3171 M14368 GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY.html Any process that activates or increases the frequency, rate or extent of protein complex assembly. 219/268 Gene Ontology BP GO:0031334 5.30918092024379e-08 2.04903449305918e-07 3485 2890.72727272727 2939 4.82652822578941e-09 1079 1.85611432194525 -1.90542745432365 -1 13.2850530334933 3481 2613 2939 2173 1079 3599 3792 3938 2476 3248 2460 3172 M12648 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation. 18/54 Gene Ontology BP GO:0002577 2.28325380730942e-07 4.33808900180104e-07 4590 3143.90909090909 2940 2.0756854947957e-08 1866 2.63313461485345 -2.45101094314954 -1 17.9681842992342 4590 3505 1866 2369 2403 3869 2822 4579 3753 1887 2940 3173 M16510 GO_ERYTHROCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERYTHROCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. 26/33 Gene Ontology BP GO:0048821 1.86622142980684e-05 2.08388008468712e-05 2280 3082.54545454545 2941 1.69657932802187e-06 1848 1.49937870228108 -1.95387563080414 -1 7.46179338731445 2280 4208 3341 4140 4147 2308 2941 2376 3855 2464 1848 3174 M15812 GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSMISSION_OF_NERVE_IMPULSE.html Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. 13/23 Gene Ontology BP GO:0051969 5.52285925851025e-06 6.53723330700794e-06 2390 2978.09090909091 2943 5.02079374826617e-07 1705 2.35497123642769 2.40135875957873 1 13.0638848800082 2387 3814 1992 4505 3905 2943 2306 1705 4436 1757 3009 3175 M10592 GO_MYELOID_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. 51/60 Gene Ontology BP GO:0061515 9.53116058136817e-07 1.35250046310174e-06 3920 2996.18181818182 2946 8.6646951914536e-08 1429 1.66378958865761 -1.88781452290167 -1 10.4251147151921 2812 3918 3321 3702 3246 2657 2946 2351 3918 2658 1429 3176 M12823 GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 51/68 Gene Ontology BP GO:0051898 1.39754142078055e-07 3.11584103061424e-07 3295 2917.54545454545 2946 1.27049228141712e-08 2031 1.82321626470176 -1.22363107870757 -1 12.6894145598396 3294 3060 2946 2038 2031 3132 3074 4335 2674 2923 2586 3177 M13769 GO_MICROGLIAL_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROGLIAL_CELL_ACTIVATION.html The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 25/50 Gene Ontology BP GO:0001774 8.94522915984171e-06 1.03340838967145e-05 4150 3085.72727272727 2946 8.13205957406279e-07 2025 2.1753620553077 2.08741780688837 1 11.5919917627847 4146 3979 2025 2946 4002 3648 2207 2725 3290 2648 2327 3178 M14902 GO_ORGANIC_CATION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CATION_TRANSPORT.html The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. 9/23 Gene Ontology BP GO:0015695 3.1003487401692e-05 3.3831901238291e-05 2770 2971.81818181818 2948 3.10039199574895e-06 1434 2.29673161891278 -2.48979349260894 -1 10.9683836011393 2769 2948 4522 3282 4257 3086 3224 2758 1434 2436 1974 3179 M11490 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE.html The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 406/551 Gene Ontology BP GO:0072594 1.89947791156088e-07 3.83772067845974e-07 2265 3406 2949 1.72679825051059e-08 2262 1.1142750182869 -1.16284609381032 -1 7.60244340071514 2339 4623 4197 4648 2264 2511 2753 2262 4303 4617 2949 3180 M10749 GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. 24/29 Gene Ontology BP GO:0051150 6.76706088152255e-07 1.01375190861959e-06 1770 2658.45454545455 2951 6.15187542093506e-08 728 2.59762192859182 3.22102942889571 1 16.6908853750381 1767 3732 1987 2951 3070 1424 728 4408 3566 3517 2093 3181 M11541 GO_MAGNESIUM_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSPORT.html The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/15 Gene Ontology BP GO:0015693 2.7153550851305e-07 4.9039641015294e-07 4155 2768.45454545455 2951 2.46850492752171e-08 887 1.91680434458572 -1.7765981115144 -1 12.9391131403441 4153 966 1846 3286 2534 4099 4103 2378 887 2951 3250 3182 M13033 GO_RESPONSE_TO_PROTOZOAN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_PROTOZOAN.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. 15/25 Gene Ontology BP GO:0001562 1.62484988932864e-06 2.13692101047094e-06 2005 3004.18181818182 2951 1.47713735399294e-07 2002 1.82170510480641 -2.26629403641706 -1 11.034773482019 2002 3225 2837 3683 3504 2697 2594 2347 4085 3121 2951 3183 M13717 GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. 9/34 Gene Ontology BP GO:0002323 7.99470103642267e-07 1.16211633622226e-06 1885 2770.72727272727 2953 7.99470391261011e-08 613 2.19858515429927 -1.82397047076906 -1 13.968773067648 1884 2953 4446 2355 3205 1785 613 4046 3729 3010 2452 3184 M15321 GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway. 61/68 Gene Ontology BP GO:2001244 3.80998400422746e-08 1.97691467186943e-07 4125 3039.09090909091 2953 3.46362188200836e-09 676 2.02428418693715 -1.77860287834415 -1 14.5329645522641 4124 2279 2485 2602 676 3798 4513 3812 3331 2857 2953 3185 M11119 GO_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING.html The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. 458/612 Gene Ontology BP GO:0006605 1.11887696386776e-07 2.7397444355352e-07 2380 3376.72727272727 2955 1.01716092797423e-08 1832 1.27720883631179 -1.12735449274521 -1 8.9323889166431 2376 4616 4193 4642 1832 2363 2762 2864 3936 4605 2955 3186 M11801 GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G1_S_TRANSITION_OF_MITOTIC_CELL_CYCLE.html Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle. 29/37 Gene Ontology BP GO:1900087 1.26013809359251e-06 1.7154542274681e-06 2370 2883.90909090909 2955 1.1455807412615e-07 1649 1.18046960775687 1.13712630270037 1 7.23230308167976 2367 3119 3654 2955 3384 2142 1649 2228 3716 4016 2493 3187 M13562 GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PATHWAY_RESTRICTED_SMAD_PROTEIN_PHOSPHORYLATION.html Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 9/12 Gene Ontology BP GO:0060394 4.69607931480967e-06 5.59241761657048e-06 800 2515.81818181818 2955 4.6960892387616e-07 404 1.28136641951441 1.34683290493408 1 7.15039944823424 800 2955 4436 4368 3896 437 404 2895 3894 3009 580 3188 M12608 GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INSULIN_LIKE_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. 21/24 Gene Ontology BP GO:0048009 2.93486746387151e-07 5.21617200511617e-07 2480 3229 2957 2.66806168671991e-08 2366 1.05622716827133 -1.06375850970362 -1 7.04857839053251 2478 2834 3628 3990 2578 2366 3731 2957 4170 3965 2822 3189 M14803 GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 40/51 Gene Ontology BP GO:0046685 1.38438752268387e-05 1.56766978414409e-05 3435 2930 2957 1.25854203114111e-06 611 1.69243761984069 1.45047325420065 1 8.66292336108715 3432 2722 2957 1928 4086 2609 2138 3709 611 3782 4256 3190 M16287 GO_MESODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the mesoderm. 9/23 Gene Ontology BP GO:0001710 1.23632501231867e-07 2.89711184326466e-07 2480 2825.72727272727 2958 1.23632508110116e-08 1734 3.43305582424103 3.65537609707321 1 24.1107258486069 2477 2958 4612 3415 2004 2639 3105 3361 1765 3013 1734 3191 M15329 GO_NUCLEOSIDE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSPORT.html The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 14/20 Gene Ontology BP GO:0015858 2.36857349523046e-07 4.42787162447061e-07 3555 2949.81818181818 2959 2.15324886385171e-08 1660 1.56825257918493 1.49368828504246 1 10.6407652301116 3553 2020 2774 2830 2442 3545 3826 1660 3807 2959 3032 3192 M10104 GO_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_DEVELOPMENT.html The progression of an endothelial cell over time, from its formation to the mature structure. 64/70 Gene Ontology BP GO:0001885 1.02052820484696e-06 1.42855527591844e-06 2925 3159 2960 9.27753343860246e-08 2494 2.1133054072228 2.21652698385823 1 13.2180958701802 2923 3898 2494 3047 3287 2650 2764 3594 2960 2653 4479 3193 M15385 GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 29/49 Gene Ontology BP GO:0045923 4.09191339249679e-07 6.756448905354e-07 4620 3148.54545454545 2961 3.71992195779707e-08 1871 1.97741736260861 -1.78698292074395 -1 13.0548449548621 4616 1871 2133 3346 2780 4067 2961 4613 3664 2149 2434 3194 M15859 GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING.html Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). 14/19 Gene Ontology BP GO:0048016 4.16955959447131e-06 5.01446389068881e-06 3065 2919.90909090909 2961 3.7905159062439e-07 1409 1.78264376650139 -1.51545504633388 -1 10.0830623240988 3061 2033 2786 2838 3843 3006 1409 3868 3717 2961 2597 3195 M16102 GO_REGULATION_OF_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_ADAPTATION.html Any process that modulates the frequency, rate or extent of muscle adaptation. 75/102 Gene Ontology BP GO:0043502 3.84747225356976e-07 6.44072598977396e-07 3730 3256.54545454545 2961 3.49770266039591e-08 2590 1.88219632059173 1.76660311875557 1 12.4629710132096 3726 3361 2666 2643 2744 3615 4102 2590 2961 2909 4505 3196 M12885 GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process. 55/92 Gene Ontology BP GO:1903727 6.27423385052914e-07 9.48473362784668e-07 4225 2810.72727272727 2962 5.70385058172179e-08 862 2.48217746249417 -2.0155736860558 -1 16.0215127291811 4221 2690 1356 862 3039 3790 2962 4024 1743 2031 4200 3197 M13274 GO_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. 19/19 Gene Ontology BP GO:0046931 2.29867502709954e-05 2.53995129448924e-05 1560 2865.09090909091 2962 2.08972640473584e-06 1482 1.52502956550263 1.41989432122124 1 7.44991601401045 1559 3489 3222 3733 4187 2345 2109 2962 1482 3861 2567 3198 M14267 GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta. 15/21 Gene Ontology BP GO:0071636 1.24148974946325e-05 1.41342104336983e-05 1630 2937.18181818182 2962 1.12863341401194e-06 1630 1.61495315018158 2.03368671321626 1 8.33953417733389 1630 3219 3015 2962 4066 2675 2164 2264 4030 3473 2811 3199 M15923 GO_CELLULAR_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. 14/14 Gene Ontology BP GO:0043482 2.11019486674642e-05 2.34113894014571e-05 1205 2652.63636363636 2962 1.91837737052225e-06 698 0.96578309829997 -1.00119804407392 -1 4.71336467137526 1202 3799 3631 3951 4172 1193 698 1251 4379 2962 1941 3200 M10192 GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT.html The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/32 Gene Ontology BP GO:0043252 8.11980038185052e-06 9.41945429487671e-06 3980 2798.18181818182 2964 8.11983005102431e-07 11 4.07196706034182 -6.62528644647984 -1 21.9740238449197 3979 2579 4231 1296 4001 3944 2964 1575 11 2510 3690 3201 M13147 GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_KINASE_A_SIGNALING.html Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. 9/19 Gene Ontology BP GO:0010738 5.49530981419482e-07 8.52322552181617e-07 455 2010.45454545455 2964 5.49531117312463e-08 4 2.17123588233305 2.17123588233305 1 14.1091123499314 453 3277 4410 3937 3014 299 4 151 2964 3534 72 3202 M16896 GO_PIGMENT_ACCUMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PIGMENT_ACCUMULATION.html The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. 14/14 Gene Ontology BP GO:0043476 2.11019486674642e-05 2.34113894014571e-05 1205 2661.90909090909 2965 1.91837737052225e-06 699 0.96578309829997 -1.00119804407392 -1 4.71336467137526 1203 3800 3632 3952 4173 1194 699 1341 4380 2965 1942 3203 M11009 GO_SERTOLI_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERTOLI_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. 17/21 Gene Ontology BP GO:0060009 7.2841404295651e-08 2.25729558068868e-07 2935 2818.45454545455 2966 6.62194606431002e-09 1407 2.83801924587802 -2.21068457497709 -1 20.2440614641272 2935 3764 2098 3423 1407 3004 2364 2966 2084 3014 3944 3204 M11828 GO_PROTEIN_LOCALIZATION_TO_LYSOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_LYSOSOME.html A process in which a protein is transported to, or maintained in, a location within a lysosome. 29/30 Gene Ontology BP GO:0061462 1.5672697041888e-07 3.35441855270951e-07 2580 3013 2967 1.42479074167306e-08 2121 1.12927888761601 -1.08927336512613 -1 7.77757782243705 2577 3116 3624 2947 2121 2372 2209 3194 4350 3666 2967 3205 M15237 GO_MITOCHONDRIAL_GENOME_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_GENOME_MAINTENANCE.html The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. 30/31 Gene Ontology BP GO:0000002 1.68690670731294e-06 2.20668454009758e-06 2685 3046.81818181818 2968 1.53355272799411e-07 2347 1.42566116684978 1.62197998771425 1 8.58972770444833 2682 2767 3392 2968 3526 2347 2493 3742 3014 3727 2857 3206 M11164 GO_REGULATION_OF_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_EFFLUX.html Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 28/34 Gene Ontology BP GO:0010874 5.32837044961471e-07 8.30861518165457e-07 4650 2875.54545454545 2969 4.84397430921756e-08 694 2.80161835647317 -1.61150575521548 -1 18.2717834359182 4649 694 1652 1068 2948 3814 4227 4109 2969 2374 3127 3207 M10049 GO_REGULATION_OF_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING_BY_RNA.html Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes. 21/27 Gene Ontology BP GO:0060966 4.96587911760008e-07 7.85926378714053e-07 2975 3019.54545454545 2971 4.51443658046135e-08 2089 1.36141036736193 -1.34351325503781 -1 8.85627688372661 2971 2841 3412 2944 2904 3572 3147 2089 2375 3753 3207 3208 M12441 GO_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUTOPHAGY.html The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. 437/578 Gene Ontology BP GO:0006914 5.6476824495804e-08 2.06162496199217e-07 1240 2291.63636363636 2971 5.13425690414878e-09 67 1.70784708669594 -1.39163763771026 -1 12.2098992728259 1237 2983 3469 4360 1150 67 1194 2997 2971 4350 430 3209 M13496 GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate, or extent of an immune system process. 1253/2113 Gene Ontology BP GO:0002682 6.44377065956179e-08 2.15972315171505e-07 3180 2879.18181818182 2972 6.4437708464116e-09 426 2.13394657286281 -1.99378024416297 -1 15.237932295538 3178 2099 4430 3023 1383 2972 3901 4540 2876 426 2843 3210 M14281 GO_MESODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MESODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. 30/48 Gene Ontology BP GO:0048333 6.19698262079598e-07 9.39848765794123e-07 855 2670.63636363636 2972 5.63362215124464e-08 855 2.54006132209605 2.87990513579872 1 16.4086437117901 855 3964 1925 3750 3027 2135 2384 3062 3228 2972 2075 3211 M15829 GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING.html Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism. 21/27 Gene Ontology BP GO:0060147 4.96587911760008e-07 7.85926378714053e-07 2975 3011.27272727273 2972 4.51443658046135e-08 1984 1.36141036736193 -1.34351325503781 -1 8.85627688372661 2972 2842 3413 2945 2905 3573 3148 1984 2376 3758 3208 3212 M15242 GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. 20/29 Gene Ontology BP GO:2000178 3.94467634242304e-08 1.97691467186943e-07 2165 2692.45454545455 2974 3.58606946650225e-09 719 1.47321022491286 1.42950465933659 1 10.5458447618219 2165 2836 3149 3199 719 1742 2201 2974 3669 3684 3279 3213 M14247 GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 15/27 Gene Ontology BP GO:0071360 9.14763343005566e-05 9.68903672889802e-05 1675 2632.90909090909 2975 8.31637619289707e-06 686 1.078637228924 -1.11560028097067 -1 4.5592700712512 1673 3532 3449 2975 4408 1539 1583 686 4431 3122 1564 3214 M10763 GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 48/78 Gene Ontology BP GO:0090218 5.70622778914679e-07 8.80696459939355e-07 3650 2788.90909090909 2976 5.18748115381308e-08 863 2.34744265825887 -1.95339526615726 -1 15.2272854582691 3646 2700 1602 863 2976 3695 4146 3675 1472 2630 3273 3215 M11496 GO_XENOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_XENOPHAGY.html The macroautophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. 103/157 Gene Ontology BP GO:0098792 5.5134266577171e-07 8.54409671541207e-07 3645 2833.45454545455 2976 5.012207308581e-08 1051 2.47805220626142 -1.91114746637655 -1 16.1160055027927 3643 1639 1051 3020 2964 3430 4065 3303 2622 2976 2455 3216 M12288 GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION_DEPENDENT_CHROMATIN_SILENCING.html Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. 9/11 Gene Ontology BP GO:0006346 2.82689502581391e-05 3.09713740407632e-05 2060 2912.27272727273 2976 2.82693098746745e-06 1163 0.866024089808424 0.885796193882863 1 4.10123309690895 2056 3276 4360 2976 4244 1928 1163 1701 4392 3899 2040 3217 M14157 GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 594/883 Gene Ontology BP GO:0071345 1.20783942400448e-07 2.86446322114824e-07 2805 2955 2977 1.20783948965391e-08 754 2.09403759727203 -1.88262410844559 -1 14.6736659004101 2803 2977 4476 2745 1985 2810 3367 4371 3018 754 3199 3218 M14284 GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. 25/38 Gene Ontology BP GO:0060117 7.10429822300245e-07 1.05611180931727e-06 2980 3100.72727272727 2977 6.45845501558389e-08 2649 2.08274726102894 2.16208535904315 1 13.3202064588078 3651 3134 2726 2977 3095 3471 2875 2721 2977 2649 3832 3219 M10433 GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of endocytosis. 135/190 Gene Ontology BP GO:0045807 1.74835444144397e-08 1.97691467186943e-07 3165 2407.09090909091 2979 1.5894131412166e-09 70 2.21746306815167 2.14150549144471 1 15.9306486989739 3162 1578 746 1141 70 3868 4403 4237 2979 517 3777 3220 M10496 GO_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAPK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. 667/931 Gene Ontology BP GO:0043408 5.51849683456264e-08 2.05617623085131e-07 3265 2567.63636363636 2979 5.51849697160478e-09 347 2.05559343652514 2.22503009213184 1 14.721618158097 3265 2111 4246 792 1227 2979 3025 3436 2514 347 4302 3221 M13198 GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 21/28 Gene Ontology BP GO:0009218 1.60999426950898e-07 3.42068645480607e-07 2980 2772.54545454545 2979 1.46363126120989e-08 843 1.04250553253443 -0.826725728524186 -1 7.16170244484299 2979 843 3577 3910 2142 2334 2113 2444 3089 3510 3557 3222 M12375 GO_SYNAPTIC_VESICLE_ENDOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_ENDOCYTOSIS.html Clathrin-mediated endocytosis of presynaptic membrane that recycles synaptic vesicle membrane and its components following synaptic vesicle exocytosis. This process starts with coating of the membrane with adaptor proteins and clathrin prior to invagination and ends when uncoating has finished. 20/27 Gene Ontology BP GO:0048488 1.24595405702386e-07 2.90889324000604e-07 3915 2702.36363636364 2980 1.13268557053416e-08 254 1.42056632529118 -1.03094287181739 -1 9.90779131246528 3911 817 2980 3064 1930 2911 2011 4403 254 3680 3765 3223 M16059 GO_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEOLYSIS.html Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 715/1000 Gene Ontology BP GO:0030162 3.52496942409607e-08 1.97691467186943e-07 3180 2913.36363636364 2981 3.52496948001041e-09 701 2.06861232344013 2.33711548054591 1 14.8536866376902 3176 2594 4591 2528 701 2981 3307 3028 2521 2942 3678 3224 M16211 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_6_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. 65/115 Gene Ontology BP GO:0032755 5.74299516029087e-07 8.85132708871593e-07 4460 2979.72727272727 2981 5.2209060540663e-08 1514 2.06646638560395 2.14705854238185 1 13.3862574279939 4458 2272 1514 2823 2981 3691 2884 3143 3115 1826 4070 3225 M12149 GO_NEGATIVE_REGULATION_OF_AUTOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_AUTOPHAGY.html Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. 58/67 Gene Ontology BP GO:0010507 2.32341835063143e-07 4.39366384950162e-07 3165 2803.90909090909 2982 2.11219872364319e-08 338 1.6472448244257 -1.10963454712988 -1 11.1884207715243 3163 2282 3347 2982 2415 3127 4465 1865 2855 4004 338 3226 M13869 GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 80/131 Gene Ontology BP GO:0042345 1.30827115451225e-06 1.76856062810735e-06 2085 3019.09090909091 2982 1.18933812045528e-07 1579 1.77563043487089 -1.45497777955481 -1 10.9102817502233 2082 4134 2982 4023 3407 2415 3525 2466 2910 3687 1579 3227 M10485 GO_TOLERANCE_INDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOLERANCE_INDUCTION.html A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. 8/14 Gene Ontology BP GO:0002507 0.000140212036470851 0.000147037774554625 2960 3171 2983 1.40220883993357e-05 1517 1.76329193218168 -2.18610071443141 -1 7.18028570176345 2599 2957 4244 3152 4437 2773 2960 3362 3897 1517 2983 3228 M16084 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_10_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. 22/42 Gene Ontology BP GO:0032733 3.54733085987931e-06 4.3152236577826e-06 4530 3161.09090909091 2984 3.22485143608228e-07 1839 1.89619356503225 -1.89193929659383 -1 10.866002085394 4529 3474 2454 2941 3800 3423 1839 2925 2742 2984 3661 3229 M10107 GO_REGULATION_OF_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 432/813 Gene Ontology BP GO:0050865 6.40386469818567e-08 2.15319129047344e-07 3000 2460.81818181818 2985 5.82169534962947e-09 260 2.14872047737644 -2.00163075844719 -1 15.3472622673732 2996 2124 439 2266 1277 3011 4233 4303 3175 260 2985 3230 M11225 GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of cytoplasmic transport. 342/480 Gene Ontology BP GO:1903651 9.79029180726714e-08 2.56809599576163e-07 2915 2878.90909090909 2986 8.90026567540741e-09 1450 1.76362308596497 1.81704132527444 1 12.4307685181169 2915 2986 3207 1450 1708 3101 2899 4243 1993 3270 3896 3231 M12214 GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling. 15/23 Gene Ontology BP GO:0034104 1.84941678814197e-08 1.97691467186943e-07 4075 2863.63636363636 2987 1.68128800335362e-09 92 2.22069417542845 -1.6881297876439 -1 15.9540263445461 4075 2494 1744 2119 92 4346 4338 3061 2987 1733 4511 3232 M13410 GO_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_ACTIVATION.html A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. 40/73 Gene Ontology BP GO:0042116 5.46082793423457e-07 8.48671756112006e-07 4265 3045.81818181818 2987 4.96439026338069e-08 1982 1.86708921494166 1.72478026697471 1 12.1206219941703 4265 3396 2160 2929 2959 3499 2284 2987 4014 1982 3029 3233 M11960 GO_GLUTAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. 22/24 Gene Ontology BP GO:0006541 2.12866171951188e-06 2.71658337380383e-06 2305 3014.90909090909 2988 1.9351488901376e-07 1073 1.18110965646776 -1.27025538506508 -1 6.9818015139937 2302 3739 3727 3985 3615 2162 1073 2988 2661 4295 2617 3234 M10569 GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 41/50 Gene Ontology BP GO:0090329 3.16723153483108e-06 3.88432481064022e-06 25 2102.27272727273 2990 2.8793055404976e-07 10 1.41040530749891 1.44469379851778 1 8.12279627215825 24 3683 3473 3703 3766 145 10 756 3494 2990 1081 3235 M13911 GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 266/357 Gene Ontology BP GO:0051091 8.08949181225276e-08 2.36286286267496e-07 4270 2975.63636363636 2990 7.35408373609708e-09 1509 1.94707637211791 -1.87791438085098 -1 13.8116015466904 4267 2990 2004 1649 1509 4429 3800 3912 2894 1989 3289 3236 M14679 GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that activates or increases the frequency, rate or extent of production of a cytokine. 352/572 Gene Ontology BP GO:0001819 9.02590492856761e-08 2.47858716290421e-07 3045 2569.90909090909 2990 8.20536845351999e-09 436 2.00930600761513 -1.94364554128169 -1 14.2116121125627 3042 2600 834 2272 1626 3520 4644 3189 3116 436 2990 3237 M10591 GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. 250/338 Gene Ontology BP GO:0070302 3.63428780564907e-07 6.17391060959662e-07 4525 3389.09090909091 2992 3.30389855092275e-08 1669 1.82270808881845 2.08459713266926 1 12.1016397854139 4524 2992 2631 1669 2705 4571 3967 4467 2955 2237 4562 3238 M10297 GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. 15/17 Gene Ontology BP GO:1904872 0.00052918050673898 0.000544992673275005 865 2784.63636363636 2993 4.81188942633016e-05 261 0.745061380412412 0.787934469591573 1 2.51115001297364 862 3533 3878 2993 4505 1341 261 2222 4184 4213 2639 3239 M14404 GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_RNA_LOCALIZATION_TO_CAJAL_BODY.html Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body. 15/17 Gene Ontology BP GO:1904874 0.00052918050673898 0.000544992673275005 865 2777.27272727273 2994 4.81188942633016e-05 262 0.745061380412412 0.787934469591573 1 2.51115001297364 863 3534 3879 2994 4506 1342 262 2129 4185 4216 2640 3240 M13750 GO_GLYCINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycine, aminoethanoic acid. 11/20 Gene Ontology BP GO:0006544 9.13264300010211e-06 1.05313972439839e-05 2910 3144.54545454545 2998 8.30243719251138e-07 926 2.12654917013828 0.988084316656368 1 11.3104901295928 2906 2941 2473 2793 4009 3254 4388 2998 926 3342 4560 3241 M16665 GO_NEUROTROPHIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROTROPHIN_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. 31/34 Gene Ontology BP GO:0038179 6.22265839616587e-07 9.42207273588018e-07 3430 2927.90909090909 2998 5.65696377839429e-08 885 2.32882226143329 -1.73015969250254 -1 15.0319108052995 3430 4460 2861 1644 3034 2998 3648 2764 885 4090 2393 3242 M11738 GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. 186/242 Gene Ontology BP GO:0043409 8.83450435202328e-08 2.45926026244086e-07 3120 2870 2999 8.03136791526279e-09 1517 1.668933593689 1.84725041056207 1 11.7911583892007 3116 1517 2984 3706 1599 3590 3293 2948 2999 2354 3464 3243 M10537 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 21/23 Gene Ontology BP GO:1902254 2.44053198193886e-06 3.07079375661479e-06 2205 2920.18181818182 3000 2.21866789936822e-07 2027 1.54354586677769 1.67570588845064 1 9.07027883622298 2204 2827 3000 3486 3668 2109 2027 3004 3611 3506 2680 3244 M11623 GO_CELL_PROLIFERATION_IN_FOREBRAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_PROLIFERATION_IN_FOREBRAIN.html The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. 25/46 Gene Ontology BP GO:0021846 3.92285689932829e-07 6.54700615228642e-07 4290 3194.27272727273 3000 3.56623418074514e-08 1539 1.91985251132296 -1.4895089187901 -1 12.6998469568301 4289 2401 2579 2808 2753 4216 4006 3031 1539 3000 4515 3245 M13489 GO_LIPID_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_TRANSLOCATION.html The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. 24/30 Gene Ontology BP GO:0034204 1.5165951151788e-06 2.01103364802706e-06 2925 2972.90909090909 3000 1.37872378241997e-07 1421 2.18407042639771 -1.97398196252471 -1 13.3144126241456 2925 2411 1943 2867 3477 3000 3326 3723 4093 1421 3516 3246 M15994 GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 166/233 Gene Ontology BP GO:0043902 5.93466596146109e-07 9.07459767291438e-07 4110 3214.90909090909 3000 5.39515232943873e-08 1799 1.51947122563617 -1.4369315947018 -1 9.79522664021247 2793 4110 3786 3814 3000 2531 2959 2963 3499 4110 1799 3247 M10642 GO_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION.html A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. 104/129 Gene Ontology BP GO:0006261 5.13189206679853e-05 5.51598378073771e-05 215 2538.81818181818 3001 4.6654652556693e-06 213 1.12700975161356 1.16260549459881 1 5.06638503382831 213 3029 4019 3001 4313 796 395 1852 4176 3826 2307 3248 M12982 GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS.html Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. 25/32 Gene Ontology BP GO:0090049 3.27592319399988e-07 5.67282122131799e-07 4400 3294.81818181818 3001 2.97811243800299e-08 1807 1.61330295978098 1.7205887497154 1 10.7623334884291 4400 1897 2479 1807 2646 4130 4283 4597 2667 3001 4336 3249 M13953 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening. 38/41 Gene Ontology BP GO:1904358 5.94674111626219e-06 7.00490649384619e-06 1735 2804.54545454545 3003 5.40614290067792e-07 1001 1.45029925958783 1.41901056324156 1 7.95492298646115 1732 3687 3767 3003 3923 1798 1001 2649 2057 4197 3036 3250 M14947 GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. 25/50 Gene Ontology BP GO:0045143 9.17170351869444e-05 9.71232054448913e-05 455 2121.18181818182 3003 8.33825991391836e-06 43 1.57585102738239 1.70462631583775 1 6.71129432822135 454 3143 3343 3905 4378 318 43 854 3538 3003 354 3251 M14441 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_INTERCONVERSION.html The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. 23/26 Gene Ontology BP GO:0015949 5.95993587581323e-07 9.10127391866063e-07 2920 2705.81818181818 3004 5.41812499127026e-08 777 1.70405255321224 1.86857574345736 1 10.9965191007282 2916 777 2520 3279 3004 3905 4478 3161 827 1613 3284 3252 M15292 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that modulates the frequency, rate or extent of protein localization to nucleus. 274/363 Gene Ontology BP GO:1900180 1.46463202044816e-07 3.21914633497652e-07 3010 2900.90909090909 3006 1.33148374359532e-08 1818 1.80998056944665 1.97315638817638 1 12.5688037479044 3006 3314 3177 1818 2064 2641 2274 3637 2117 3892 3970 3253 M11724 GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 157/222 Gene Ontology BP GO:0070304 4.06495834146865e-07 6.72377112879102e-07 4190 3056 3008 3.6954173568678e-08 1629 1.92684082725324 -1.7734256186103 -1 12.7224261686919 4190 3008 2072 1646 2774 4433 3923 3564 2483 1629 3894 3254 M13529 GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_DETECTION_OF_MOLECULE_OF_BACTERIAL_ORIGIN.html The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. 14/25 Gene Ontology BP GO:0032490 0.000370617518064743 0.000383644785663015 2105 3120.72727272727 3009 3.36981789045973e-05 1960 1.36431441532303 -1.54807159303038 -1 4.91676261866056 2101 3543 3025 2650 4482 2437 4075 3009 4497 1960 2549 3255 M12750 GO_ATP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. 36/46 Gene Ontology BP GO:0006754 0.00436116845283434 0.00443940424656272 615 2962 3010 0.000397257989252896 611 1.01818783940157 -0.999246317193215 -1 2.4721639740746 611 4462 4012 3010 4629 1805 945 1940 4058 4445 2665 3256 M14807 GO_CARDIOLIPIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOLIPIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. 14/15 Gene Ontology BP GO:0032048 1.01796630989807e-06 1.42539790549374e-06 2855 2798.27272727273 3010 9.25424346294144e-08 1009 1.41913009937275 -0.826896140647346 -1 8.84055766490468 2855 1009 3010 3903 3286 2564 1826 3101 2180 3990 3057 3257 M10536 GO_CELL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CHEMOTAXIS.html The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). 146/236 Gene Ontology BP GO:0060326 8.53522687745736e-08 2.43199085491789e-07 3675 2551.09090909091 3011 7.75929746235834e-09 274 2.73622430149528 2.7887999305558 1 19.4182850469383 3672 3011 274 1328 2147 3157 3474 3577 2935 468 4019 3258 M10978 GO_RESPONSE_TO_HEAT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEAT.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. 99/130 Gene Ontology BP GO:0009408 2.45892237129821e-07 4.55468383505198e-07 3310 2827.63636363636 3012 2.23538422375458e-08 1210 2.21433781827703 1.99767937145878 1 15.0418115341024 3306 3030 2161 1210 2468 3334 3618 3249 3003 2713 3012 3259 M11845 GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. 151/171 Gene Ontology BP GO:0035967 2.36151511105516e-08 1.97691467186943e-07 2755 3136.81818181818 3012 2.14683194218548e-09 208 1.15296724477852 -1.16221608624165 -1 8.22882887677904 2754 4344 4128 4476 208 2614 2542 2761 3012 4554 3112 3260 M13091 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_I.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. 102/138 Gene Ontology BP GO:0002474 6.03878551849726e-07 9.20054650215055e-07 1405 2640.81818181818 3012 5.48980652371424e-08 564 1.22312489996966 -1.08714168303076 -1 7.8548789731331 564 3353 4048 3829 3012 1405 1189 1901 4277 4067 1404 3261 M13926 GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. 139/188 Gene Ontology BP GO:0050852 8.28032207782875e-06 9.59370981776324e-06 1680 3066.90909090909 3013 7.52759385756952e-07 1680 1.4415988793417 -1.29891324056134 -1 7.69402240147142 1680 4348 4087 3013 3989 2113 2245 1691 4253 4422 1895 3262 M10222 GO_SULFUR_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFUR_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. 324/421 Gene Ontology BP GO:0006790 1.83466953937043e-08 1.97691467186943e-07 4205 2500.09090909091 3014 1.66788141333681e-09 88 2.15111179353928 -1.87421724344421 -1 15.4505852259034 4204 1353 711 3014 88 3561 3432 4169 1955 674 4340 3263 M11892 GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. 290/400 Gene Ontology BP GO:1901565 5.44283669118159e-08 2.05617623085131e-07 4530 2719.63636363636 3015 4.94803347803481e-09 927 2.19237813818358 -1.91327625662565 -1 15.7087599460848 4530 1381 927 3015 1108 3942 3984 3992 1311 1339 4387 3264 M12260 GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. 176/247 Gene Ontology BP GO:1900182 5.68677227549956e-07 8.78212791168253e-07 3020 3063.90909090909 3016 5.16979431406533e-08 2014 1.82121741558836 1.94280156542575 1 11.7908488504878 2819 3325 3016 2224 2974 3020 2014 4511 2410 3633 3757 3265 M10829 GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving an alpha-amino acid. 200/255 Gene Ontology BP GO:1901605 9.89773560841107e-08 2.5728583120635e-07 4640 3039.36363636364 3017 8.99794186700665e-09 1379 2.09952255696389 -2.32515254069987 -1 14.8180488233195 4638 2166 2106 3017 1725 4018 3663 3821 1379 2655 4245 3266 M11958 GO_MITOTIC_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_CELL_CYCLE_ARREST.html The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M). 17/18 Gene Ontology BP GO:0071850 3.39733730099922e-07 5.83098873535573e-07 2875 3035.54545454545 3017 3.08848893239198e-08 518 1.60506449161056 -1.35499261330626 -1 10.6861088996163 2873 2876 2890 3412 2670 3618 4636 518 3541 3017 3340 3267 M14986 GO_HISTONE_H3_K4_TRIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_TRIMETHYLATION.html The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. 16/18 Gene Ontology BP GO:0080182 5.7674884850598e-05 6.1862895161326e-05 1065 2941.90909090909 3017 5.24330880932847e-06 1062 2.6030132536645 -2.77283098148485 -1 11.7098431016816 1062 4275 2448 4175 4322 2128 1810 3017 3501 3258 2365 3268 M15245 GO_LINOLEIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LINOLEIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. 19/30 Gene Ontology BP GO:0043651 6.08662972373014e-07 9.26131069474047e-07 4505 2920.27272727273 3017 5.53330127971649e-08 1209 2.60561158709216 2.92717158250919 1 16.8529696100221 4505 1962 1209 1879 3017 4305 3942 3458 2194 1297 4355 3269 M13871 GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TISSUE_REMODELING.html Any process that activates or increases the frequency, rate, or extent of tissue remodeling. 22/31 Gene Ontology BP GO:0034105 4.23939556725609e-08 1.97691467186943e-07 3020 2861.36363636364 3018 3.85399604449924e-09 797 2.24623545986263 -2.34354013339037 -1 16.1388221571931 3018 2429 1329 3628 797 3852 4619 3481 4292 1151 2879 3270 M13873 GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING.html The process in which the neural tube is regionalized in the dorsoventral axis. 17/25 Gene Ontology BP GO:0021904 2.55001070422867e-06 3.19128558546961e-06 4540 2673.90909090909 3019 2.31819423630918e-07 826 2.04743763268799 -1.74694813030189 -1 12.03126484475 4536 903 2143 826 3688 3526 3598 2932 1205 3019 3037 3271 M15236 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_GOLGI.html The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. 77/82 Gene Ontology BP GO:0042147 2.52011361493504e-08 1.97691467186943e-07 3020 3048.63636363636 3019 2.29101240345735e-09 271 1.15508318017721 -1.11306716424852 -1 8.24413805210722 3019 3637 4030 3992 271 2920 2859 2231 2994 4372 3210 3272 M15695 GO_REGULATION_OF_SISTER_CHROMATID_COHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SISTER_CHROMATID_COHESION.html Any process that modulates the frequency, rate or extent of sister chromatid cohesion. 20/21 Gene Ontology BP GO:0007063 0.000531694373812971 0.000547460482706739 1370 3064.54545454545 3019 4.83475378919063e-05 1367 2.01971147710037 2.36520795684588 1 6.99643286616086 1367 3761 3406 2961 4507 3019 3064 2592 2724 3685 2624 3273 M12000 GO_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule. 45/83 Gene Ontology BP GO:0070988 1.08361736657658e-06 1.50419797335347e-06 2180 2941.09090909091 3020 9.85107182105739e-08 723 1.69106279306821 1.24805874015132 1 10.5136013548125 2179 4168 3487 4159 3317 2666 2028 2265 723 4340 3020 3274 M13550 GO_CHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. 583/846 Gene Ontology BP GO:0006325 5.24151074630398e-07 8.20893621762114e-07 1655 3134 3021 5.24151198260896e-08 1655 1.46973279650972 1.45501492206381 1 9.53995032368552 1655 4091 4434 3847 2983 1903 2071 2698 3208 4563 3021 3275 M15992 GO_NEUTRAL_AMINO_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUTRAL_AMINO_ACID_TRANSPORT.html The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 25/38 Gene Ontology BP GO:0015804 5.15945765998672e-08 2.03777546037507e-07 4375 2512.81818181818 3021 4.69041616453341e-09 715 2.60006676108539 -2.26591886803018 -1 18.661904107441 4372 715 1274 3021 1042 4076 3284 3246 1642 1019 3950 3276 M12156 GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_DEPENDENT_DNA_REPLICATION.html Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication. 10/13 Gene Ontology BP GO:2000105 2.48462481036501e-05 2.73696951766771e-05 660 2291.72727272727 3022 2.25877533776183e-06 123 1.84518124733631 1.84518124733631 1 8.97302111775829 656 4077 3022 3719 4509 846 123 417 3542 3203 1095 3277 M16766 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. 149/198 Gene Ontology BP GO:0032387 3.68028331272758e-08 1.97691467186943e-07 2890 2860.18181818182 3022 3.34571215844856e-09 646 1.74563194597584 2.04105439968159 1 12.5168651878399 2888 3014 3197 3475 646 2294 3151 3022 2789 3662 3324 3278 M12624 GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE.html A cascade of processes induced by the detection of DNA damage within a cell. 115/128 Gene Ontology BP GO:0042770 4.85623715557168e-07 7.72251246919858e-07 1710 2757.09090909091 3023 4.41476202502577e-08 1304 1.5352187171358 1.61981139772186 1 10.0140083764949 1707 3346 3618 3230 2893 1336 1304 2909 3084 3878 3023 3279 M10998 GO_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. 109/161 Gene Ontology BP GO:0002573 2.05531887711287e-07 4.04885636545563e-07 3780 2846.54545454545 3024 1.86847188102559e-08 1786 2.11901818796728 -1.80412749803619 -1 14.5063651048652 3779 2220 1786 2203 2321 3320 3708 2581 3024 3151 3219 3280 M15977 GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. 117/146 Gene Ontology BP GO:0031098 8.87802469121062e-08 2.46335138997725e-07 2130 2765.36363636364 3024 8.07093186316388e-09 1604 1.6164827061322 -1.78471578540806 -1 11.4157746257697 2126 3024 3541 3492 1604 2492 3125 1812 3382 3562 2259 3281 M13785 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK.html The synchronization of a circadian rhythm to environmental time cues such as light. 44/73 Gene Ontology BP GO:0009649 1.32234860306073e-07 3.01316750736611e-07 4455 3132.81818181818 3027 1.20213516594802e-08 1586 2.083108421486 -1.63452402124762 -1 14.5470764727011 4454 3390 2441 4498 1983 3534 2508 4427 1586 3027 2613 3282 M13701 GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS.html Any process that modulates the frequency, rate, or extent of B cell apoptotic process. 19/27 Gene Ontology BP GO:0002902 5.83874264947568e-06 6.88804083080444e-06 2265 2863.81818181818 3028 5.3079619503673e-07 809 1.54302508510287 1.50847945199975 1 8.48292472335041 2265 3185 3107 2937 3918 1962 809 2926 4083 3282 3028 3283 M14907 GO_PROTEIN_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEPHOSPHORYLATION.html The process of removing one or more phosphoric residues from a protein. 183/224 Gene Ontology BP GO:0006470 6.21772723845237e-08 2.12948256567067e-07 3585 3090.09090909091 3028 5.65247946743659e-09 1248 1.81163429336941 2.06360805932036 1 12.9312790805667 3584 2617 2922 3050 1248 3028 2856 4401 3015 3339 3931 3284 M15093 GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. 14/16 Gene Ontology BP GO:0010667 3.33266212098401e-07 5.74541565355264e-07 4340 2982.36363636364 3029 3.02969329621022e-08 1012 2.22907436156696 -1.49911846404868 -1 14.9000229572676 4337 1012 2015 1790 2656 4432 4083 3029 3799 1964 3689 3285 M10260 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_OR_POLYSACCHARIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. 108/134 Gene Ontology BP GO:0002504 2.82746313769256e-08 1.97691467186943e-07 3855 2667 3030 2.57042106730129e-09 72 1.90546156994611 1.69219131064497 1 13.6732614263592 3852 72 2418 3030 364 4520 3643 3890 1275 1693 4580 3286 M13436 GO_RESPONSE_TO_INTERLEUKIN_1 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_1.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. 127/188 Gene Ontology BP GO:0070555 9.62873854888929e-08 2.53938011162528e-07 3375 2853.81818181818 3030 8.75339906391842e-09 1638 1.93024713252303 1.88300617223145 1 13.6260645231101 3374 2636 2272 1638 1698 3030 2924 3590 3186 3085 3959 3287 M14374 GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLASE_ACTIVITY.html Any process that activates or increases the activity of a cyclase. 43/72 Gene Ontology BP GO:0031281 2.49438459725316e-08 1.97691467186943e-07 3680 2607.90909090909 3030 2.26762238684978e-09 258 1.93944229224142 1.98627185968577 1 13.91911809841 3680 488 2214 1605 258 3187 3030 4552 3540 2057 4076 3288 M15726 GO_CHROMATIN_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_REMODELING.html Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. 159/292 Gene Ontology BP GO:0006338 7.50432181133261e-07 1.10393959494564e-06 3135 2682.54545454545 3030 6.82211306463595e-08 1419 1.75386608866538 1.7936508649411 1 11.1625792222324 1419 3610 3195 3135 3132 1636 2104 3030 1682 3798 2767 3289 M10689 GO_PHOTOPERIODISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOPERIODISM.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. 36/67 Gene Ontology BP GO:0009648 1.36162075820065e-07 3.07256129384464e-07 4490 2920.18181818182 3031 1.23783712952172e-08 1681 2.07687669131741 2.58290474628658 1 14.4842185431433 4490 3686 2539 3667 2006 3229 1877 3343 1681 3031 2573 3290 M15120 GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN_VIA_MHC_CLASS_II.html The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. 108/134 Gene Ontology BP GO:0002495 2.82746313769256e-08 1.97691467186943e-07 3855 2661.90909090909 3031 2.57042106730129e-09 73 1.90546156994611 1.69219131064497 1 13.6732614263592 3853 73 2419 3031 365 4521 3644 3824 1276 1694 4581 3291 M15690 GO_REGULATION_OF_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H4_ACETYLATION.html Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group. 14/16 Gene Ontology BP GO:0090239 4.97533472381299e-05 5.35141758435086e-05 1060 2666.54545454545 3033 4.52313385941422e-06 283 1.17053606331751 0.872353694432976 1 5.28303950125924 1056 2906 3458 2215 4311 1147 283 3286 3451 4186 3033 3292 M12277 GO_ALDITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALDITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. 18/26 Gene Ontology BP GO:0019400 7.02368771975485e-06 8.20517674115473e-06 2265 2953.09090909091 3034 6.38519103961584e-07 1091 1.66423781478235 -1.20866256304481 -1 9.02169798342483 2263 4012 3034 3455 3957 2766 2931 1091 2192 3482 3301 3293 M14184 GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_SYNTHESIS_INVOLVED_IN_DNA_REPAIR.html Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. 78/91 Gene Ontology BP GO:0000731 2.98380745651942e-06 3.67389682328257e-06 890 2566.54545454545 3035 2.71255591217626e-07 679 1.31616265056019 1.44389851495171 1 7.60683602394923 888 3035 3724 3714 3751 875 679 2064 3699 3602 2201 3294 M13201 GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_MITOCHONDRIAL_PROMOTER.html The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. 14/16 Gene Ontology BP GO:0006390 7.64706117649047e-06 8.89322060840044e-06 3000 2876.18181818182 3038 6.95189796120175e-07 587 1.12891436982363 -1.27366620853804 -1 6.04076634242194 2999 2915 3617 3517 3974 3038 2300 587 4306 3361 1024 3295 M13311 GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 20/23 Gene Ontology BP GO:0035729 4.787530982646e-07 7.63412668343106e-07 3950 2827.90909090909 3039 4.35230184044098e-08 857 2.35578980611785 2.22028011232093 1 15.4396350151162 3946 3167 2452 857 2884 3039 2268 4217 1675 3052 3550 3296 M13705 GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_HEPATOCYTE_GROWTH_FACTOR.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. 20/23 Gene Ontology BP GO:0035728 4.787530982646e-07 7.63412668343106e-07 3950 2827.45454545455 3040 4.35230184044098e-08 858 2.35578980611785 2.22028011232093 1 15.4396350151162 3947 3168 2453 858 2885 3040 2269 4201 1676 3054 3551 3297 M12271 GO_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEIOSIS_I.html The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. 70/204 Gene Ontology BP GO:0007127 5.66855506471262e-06 6.69266346513774e-06 200 2239.27272727273 3043 5.15324515495875e-07 151 1.3207970928237 1.42631693457538 1 7.26273051630591 199 3043 3722 3707 3914 215 151 1097 4126 3454 1004 3298 M15503 GO_MONOCYTE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_CHEMOTAXIS.html The movement of a monocyte in response to an external stimulus. 21/54 Gene Ontology BP GO:0002548 6.35351773725153e-07 9.59212135997125e-07 3440 2707.09090909091 3043 5.77592688374948e-08 713 3.47756288391526 -3.81491631511209 -1 22.4733503346772 3438 851 713 1517 3043 4499 4291 4008 3401 1030 2987 3299 M13660 GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. 60/88 Gene Ontology BP GO:1901222 5.9938435547598e-07 9.14158547403981e-07 3370 3118 3045 5.44895017069793e-08 341 1.75874906127869 -1.67280681708133 -1 11.3494713747318 3367 341 2810 2605 3007 3796 4622 4461 3045 2522 3722 3300 M10690 GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an alpha-amino acid. 69/84 Gene Ontology BP GO:1901607 3.06461528279858e-07 5.38913639866282e-07 2575 2938 3046 2.78601428154701e-08 646 1.98957075522106 1.68531049321676 1 13.3466306736921 2571 1703 2654 3278 2607 3876 4539 3273 646 3046 4125 3301 M11137 GO_POLYOL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYOL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. 19/24 Gene Ontology BP GO:0046174 6.36940869458564e-07 9.60987634757036e-07 3040 2736.72727272727 3046 5.79037321695321e-08 701 1.0118984180517 -1.15402688054335 -1 6.45821150082041 3038 2445 3448 3104 3046 3248 3550 701 1964 4049 1511 3302 M15745 GO_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIN_CYTOSKELETON_REORGANIZATION.html A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. 82/107 Gene Ontology BP GO:0031532 6.81102444514695e-08 2.20228333272585e-07 3825 3084.36363636364 3046 6.19184059637351e-09 1344 1.69755451228084 -1.32861302807004 -1 12.0831199047882 3825 1669 2548 2540 1344 3046 4080 4193 2958 3192 4533 3303 M10131 GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 44/65 Gene Ontology BP GO:0050854 2.38705277892104e-08 1.97691467186943e-07 3635 2365.45454545455 3047 2.17004800438284e-09 221 2.25747838831831 -2.31858848243809 -1 16.2201667781283 3631 412 975 982 221 4105 4234 3720 3047 420 4273 3304 M15953 GO_EXECUTION_PHASE_OF_APOPTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXECUTION_PHASE_OF_APOPTOSIS.html A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. 63/76 Gene Ontology BP GO:0097194 1.46355278353085e-07 3.21829447153546e-07 3335 2798.63636363636 3047 1.33050261899445e-08 514 1.94753428286218 -2.10368494948154 -1 13.5328361409544 3333 3047 2871 3082 2063 3122 3563 2954 514 3405 2831 3305 M16659 GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. 38/47 Gene Ontology BP GO:0072528 1.11577635667771e-06 1.54469127867343e-06 2500 2992.90909090909 3047 1.01434265687964e-07 1801 1.36504887450831 1.5075096572635 1 8.44792233523862 2496 1801 3270 2848 3328 3431 4368 3047 1848 2673 3812 3306 M10618 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES.html Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species. 20/24 Gene Ontology BP GO:1901032 8.59176485958983e-07 1.23692703872746e-06 2755 2810.63636363636 3048 7.81069837724959e-08 1533 2.37246750208818 2.59297842862341 1 15.0131103672132 2752 3178 2121 1604 3199 3042 3548 3319 1533 3048 3573 3307 M11627 GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway. 29/44 Gene Ontology BP GO:0045746 3.80811957230915e-06 4.60477660341852e-06 2855 2854.27272727273 3049 3.4619328764008e-07 1219 2.84669672438076 -2.01372215314691 -1 16.2828316197255 2854 2765 1219 3049 3820 3081 3547 4302 1838 1496 3426 3308 M13817 GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_P38MAPK_CASCADE.html Any process that activates or increases the frequency, rate or extent of p38MAPK cascade. 15/19 Gene Ontology BP GO:1900745 6.52481458346411e-06 7.64349502942056e-06 4290 2820.27272727273 3049 5.93166721363766e-07 721 2.27896125319583 2.6796747548916 1 12.4715824257775 4287 3522 2063 3419 3944 3049 2757 721 1527 1736 3998 3309 M10583 GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_FATE_COMMITMENT.html Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. 4/13 Gene Ontology BP GO:0010455 2.61984193337989e-05 2.87910357015036e-05 4315 3197.72727272727 3050 2.61987281996527e-06 1333 2.67061026925082 -2.51364264976713 -1 12.9742612656244 4315 2586 4248 2320 4229 4142 3050 3948 1333 2214 2790 3310 M13409 GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. 10/12 Gene Ontology BP GO:0070897 9.12747397155528e-06 1.05280457088861e-05 2080 2990.72727272727 3050 8.29773803664736e-07 1252 1.54043796258255 1.0444835599711 1 8.16219511855168 2076 4061 3254 4515 4008 2304 1948 1252 2782 3648 3050 3311 M12573 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PROCESS.html Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. 266/314 Gene Ontology BP GO:0010948 7.25830587176446e-07 1.0748853348606e-06 1170 2671 3051 6.59846206040689e-08 1086 1.51800921005409 1.71549422024399 1 9.66522221029657 1170 4097 3945 4278 3109 1168 1086 1638 3051 4151 1688 3312 M11463 GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_IN_CELL.html The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell. 1776/2289 Gene Ontology BP GO:0051649 4.01570237848894e-08 1.97691467186943e-07 3025 3063.54545454545 3052 4.01570245105534e-09 854 1.58866894812143 -1.40619053119121 -1 11.3812095077683 3021 3578 4303 3782 854 2394 3052 3084 2252 4573 2806 3313 M10464 GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATIDYLINOSITOL_3_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. 56/88 Gene Ontology BP GO:0043551 3.28652153734814e-07 5.68283931846269e-07 4350 3053.54545454545 3053 2.98774729846632e-08 867 2.18155203560875 -2.06963165008476 -1 14.5911512987719 4347 3053 1857 867 2649 4259 3734 4130 1658 2887 4148 3314 M13445 GO_LIVER_REGENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIVER_REGENERATION.html The regrowth of lost or destroyed liver. 20/26 Gene Ontology BP GO:0097421 5.08828507139099e-06 6.04128360224095e-06 1320 2685.27272727273 3053 4.6257243999128e-07 295 1.50107153335697 1.38989774636347 1 8.34149203852851 1317 3483 3153 3162 3892 1863 295 2838 2750 3053 3732 3315 M13294 GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CIRCADIAN_SLEEP_WAKE_CYCLE_NON_REM_SLEEP.html Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. 7/13 Gene Ontology BP GO:0045188 2.4702882801557e-05 2.72246598000106e-05 4305 3136.72727272727 3054 2.47031574104417e-06 1057 1.64588823950257 -1.69843652964914 -1 7.99575293719474 4302 2963 4418 2926 4219 3979 3054 1404 4341 1841 1057 3316 M15297 GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 418/577 Gene Ontology BP GO:0051090 5.43621571251667e-08 2.05617623085131e-07 3780 2915 3054 4.9420144062236e-09 1106 1.85388271476979 -1.73780667172071 -1 13.2659211385057 3777 2131 2489 1266 1106 4010 4330 4375 3054 2353 3174 3317 M15004 GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. 69/80 Gene Ontology BP GO:0043666 7.13994844861505e-08 2.23814099129341e-07 2365 3182.18181818182 3055 6.49086243667016e-09 1391 1.49895532842434 1.7723005956575 1 10.644920928065 2361 4144 3731 4244 1391 2559 2602 3826 3055 4046 3045 3318 M16271 GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 20/27 Gene Ontology BP GO:0042454 6.51617325129662e-07 9.80904371992338e-07 3455 2793.63636363636 3055 5.92379561938252e-08 872 2.24300233386831 2.5587414023272 1 14.4314841659338 3452 3159 1962 2264 3055 4050 4420 2117 872 1858 3521 3319 M10527 GO_RESPONSE_TO_COLD http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COLD.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. 62/78 Gene Ontology BP GO:0009409 1.18937596899387e-07 2.84386761753776e-07 3675 3052.54545454545 3056 1.0812509393587e-08 1886 2.04374234896031 2.08544129214408 1 14.32542509554 3674 3652 1997 3453 1886 2722 3056 2158 3785 2943 4252 3320 M12204 GO_CITRULLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CITRULLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. 9/13 Gene Ontology BP GO:0000052 5.92842207136601e-07 9.07399601910067e-07 4470 2917.72727272727 3056 5.92842365294508e-08 364 2.73936000533515 -3.17487428374345 -1 17.7500880512479 4466 1101 4356 2279 3056 3924 3250 2775 364 3532 2992 3321 M12798 GO_MAINTENANCE_OF_LOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION.html Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. 157/197 Gene Ontology BP GO:0051235 1.67030927189989e-07 3.51036542102538e-07 3060 2943.54545454545 3056 1.51846308974095e-08 1482 1.74201317797255 -1.63496154541916 -1 12.021868826041 3973 2186 2809 3056 2169 2790 3159 4555 3057 1482 3143 3322 M15157 GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION.html Any process that activates or increases the frequency, rate, or extent of peptide secretion. 81/128 Gene Ontology BP GO:0002793 1.33444885347778e-07 3.03183130626567e-07 4310 2945.72727272727 3057 1.21313539492831e-08 939 2.42251533975186 2.62809081915425 1 16.9286899839926 4310 2659 1217 3057 1990 3692 3513 4128 2836 939 4062 3323 M15291 GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of macrophage differentiation. 20/25 Gene Ontology BP GO:0045649 8.39736170494199e-07 1.21231535876808e-06 2270 2858.81818181818 3057 7.63396810018369e-08 1371 1.9365048334891 -2.24582767734958 -1 12.2517728344457 2266 3752 2267 4106 3189 3057 3299 1371 3844 1853 2443 3324 M12448 GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 23/29 Gene Ontology BP GO:0060099 1.66630047082333e-07 3.50352286070536e-07 3060 3123.81818181818 3058 1.51481872457318e-08 1640 2.64746552922606 -2.21635878537076 -1 18.3317244265287 3058 3735 1640 4135 2167 2683 2453 3642 4269 2360 4220 3325 M14203 GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of epidermal cell differentiation. 54/67 Gene Ontology BP GO:0045604 3.15319221830126e-06 3.86812638854621e-06 4140 3041 3058 2.86654248880326e-07 1461 2.59731990347702 2.65485138208127 1 15.0587301268175 4139 3058 1461 3117 3765 3853 4623 2546 1662 2716 2511 3326 M14021 GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. 53/78 Gene Ontology BP GO:0002066 2.1422827104425e-07 4.15243912302656e-07 4380 3151.72727272727 3059 1.94752992640954e-08 1729 2.16805975646732 2.27461803020908 1 14.8190409906364 4380 3059 2370 2440 2358 4119 3852 3740 1729 2065 4557 3327 M15211 GO_DNA_INTEGRITY_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRITY_CHECKPOINT.html A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. 173/197 Gene Ontology BP GO:0031570 2.9485080836468e-07 5.23321537821719e-07 2300 2924.45454545455 3059 2.68046225346823e-08 1829 1.5791576338861 1.65373417964874 1 10.5918581887759 2299 3609 3640 3191 2581 1829 2110 3059 2730 3623 3498 3328 M15230 GO_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that modulates the frequency, rate or extent of membrane invagination. 23/29 Gene Ontology BP GO:1905153 1.66630047082333e-07 3.50352286070536e-07 3060 3121.63636363636 3059 1.51481872457318e-08 1641 2.64746552922606 -2.21635878537076 -1 18.3317244265287 3059 3736 1641 4136 2168 2684 2454 3605 4270 2364 4221 3329 M12032 GO_NEGATIVE_REGULATION_OF_CELL_AGING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_AGING.html Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan. 22/27 Gene Ontology BP GO:0090344 1.78420183847997e-06 2.31702237076397e-06 3250 2355.63636363636 3060 1.62200298679163e-07 217 1.94529317153306 2.23776959521065 1 11.7172896790781 1224 4491 3060 3249 3552 926 217 1233 3246 4157 557 3330 M16361 GO_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. 433/581 Gene Ontology BP GO:0006979 5.4832683579971e-08 2.05617623085131e-07 3175 2587.45454545455 3060 4.98478954060164e-09 1116 2.05238210784749 2.2037196703912 1 14.6984427832616 3175 2125 1151 3060 1116 3106 3612 3158 2532 2204 3223 3331 M10406 GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 15/20 Gene Ontology BP GO:0038084 0.000126296242843249 0.000132758543759832 1635 2858 3061 1.14821357966194e-05 1367 1.533881561547 1.82230904297625 1 6.30483612798535 1633 4038 3061 4021 4413 1772 1367 1574 4539 3116 1904 3332 M10565 GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_LEFT_VENTRICLE_MORPHOGENESIS.html The process in which the left cardiac ventricle is generated and organized. 12/18 Gene Ontology BP GO:0003214 1.94586127099124e-06 2.50389726048734e-06 4070 2614.18181818182 3063 1.76896635643037e-07 801 1.75245870773208 1.65315781153356 1 10.4808471218002 4066 2028 2229 1080 3582 3345 3428 822 801 3063 4312 3333 M11659 GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 26/33 Gene Ontology BP GO:0046134 7.16522355438663e-07 1.06380935541037e-06 2735 2925.27272727273 3063 6.51384171640322e-08 733 1.33781337161925 1.57807853587971 1 8.51097791009457 2735 733 3063 3874 3100 3625 4518 2434 2051 2457 3588 3334 M12418 GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of mast cell degranulation. 10/16 Gene Ontology BP GO:0043306 7.9701783253287e-07 1.15963851618995e-06 3065 2800.09090909091 3063 7.2456192843391e-08 1421 2.2576346681163 2.35259842275793 1 14.3492419831963 3063 2566 2501 1421 3163 3134 1821 4164 3495 3204 2269 3335 M12743 GO_PROTEIN_POLYUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_POLYUBIQUITINATION.html Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. 270/313 Gene Ontology BP GO:0000209 2.5786245156181e-07 4.71262367288727e-07 1970 3226.90909090909 3063 2.34420437987205e-08 1969 1.31820002995698 -1.41644938331561 -1 8.88759057109518 1969 4634 4168 4472 2504 2393 2627 3096 3063 4499 2071 3336 M12939 GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MAST_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. 10/16 Gene Ontology BP GO:0033008 7.9701783253287e-07 1.15963851618995e-06 3065 2804.18181818182 3064 7.2456192843391e-08 1422 2.2576346681163 2.35259842275793 1 14.3492419831963 3064 2567 2502 1422 3164 3135 1822 4197 3496 3207 2270 3337 M12352 GO_CENTRIOLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CENTRIOLE_ASSEMBLY.html A cellular process that results in the assembly of one or more centrioles. 20/27 Gene Ontology BP GO:0098534 2.28464103965639e-06 2.89342263405584e-06 1175 2576.36363636364 3065 2.07694855654393e-07 961 1.31415999082479 1.14442017204675 1 7.74218677006448 1175 3479 3575 3445 3644 1646 1210 2223 961 3917 3065 3338 M13229 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter. 27/31 Gene Ontology BP GO:0006356 7.97974831340213e-07 1.16066798694155e-06 2245 2846.36363636364 3065 7.25431927980422e-08 771 1.98070673912312 1.48704995316905 1 12.5744262211146 2243 3129 2965 2192 3165 2903 3065 4315 771 3244 3318 3339 M11200 GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACTIN_CYTOSKELETON_REORGANIZATION.html Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. 21/26 Gene Ontology BP GO:2000251 1.46853017730333e-06 1.95743820833371e-06 2180 3017 3066 1.33502832506207e-07 2176 2.19718731315467 2.34030270510081 1 13.42287238105 2900 2811 2180 3165 3461 2566 2176 4274 3066 3179 3409 3340 M12351 GO_RESPONSE_TO_TESTOSTERONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_TESTOSTERONE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. 45/66 Gene Ontology BP GO:0033574 2.50455858554284e-07 4.6171597062325e-07 4625 3261.45454545455 3069 2.2768717006098e-08 1742 2.24367641876981 -2.5566843693997 -1 15.2282777895176 4624 2708 1855 3069 2478 4475 4637 3971 1759 1742 4558 3341 M13546 GO_KERATAN_SULFATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KERATAN_SULFATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. 12/15 Gene Ontology BP GO:0042340 1.76344005463241e-07 3.65481746361674e-07 4030 3266.18181818182 3070 1.60312745089397e-08 2192 2.10059312546269 -1.10423467214721 -1 14.4800546278196 4030 2926 2374 3636 2201 4409 4496 2192 2215 3070 4379 3342 M15816 GO_PYRUVATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRUVATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. 57/83 Gene Ontology BP GO:0006090 2.1144744825398e-07 4.12003759097892e-07 3895 3104 3070 1.92224971433382e-08 2345 1.59550411122286 -1.56425141272047 -1 10.8815205927065 3892 2691 3194 4120 2345 2982 2749 3070 2797 3178 3126 3343 M13745 GO_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_CELL_POLARITY.html The maintenance of established anisotropic intracellular organization or cell growth patterns. 12/17 Gene Ontology BP GO:0030011 2.6318162125638e-05 2.89157989068698e-05 3905 3243.63636363636 3071 2.39258881544057e-06 1595 1.78922377564852 -1.48104461013431 -1 8.65138954143397 3904 4051 3043 3669 4213 3067 2711 1850 1595 3071 4506 3344 M14277 GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. 43/56 Gene Ontology BP GO:0051353 6.77536108363679e-07 1.01466865536408e-06 3455 3181 3071 6.15942106386558e-08 2203 2.20081485569842 -2.32992068103671 -1 14.1230130886343 3453 3678 2203 2616 3071 4103 4023 2814 2284 2932 3814 3345 M15403 GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_SUMOYLATION.html Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein. 16/17 Gene Ontology BP GO:0033235 2.84830654137617e-07 5.09737320654743e-07 3300 2938.54545454545 3071 2.58936991831105e-08 1909 1.48524074466307 -1.23705460817451 -1 9.97351355923396 3296 2870 2730 3150 2558 3292 3071 3163 3023 3262 1909 3346 M10476 GO_REGULATION_OF_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINE_PRODUCTION.html Any process that modulates the frequency, rate, or extent of production of a cytokine. 547/853 Gene Ontology BP GO:0001817 1.22817006208746e-07 2.88827351555887e-07 2815 2923.09090909091 3072 1.22817012996554e-08 378 2.09079009050557 -2.01736366570582 -1 14.6426219926411 2815 3301 4243 2257 2002 3072 4067 3942 2992 378 3085 3347 M10534 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS.html Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. 16/17 Gene Ontology BP GO:0010561 4.41251120570959e-08 1.97691467186943e-07 4325 3071.90909090909 3072 4.01137390382797e-09 851 1.74964594073757 -1.53526579341608 -1 12.5459071659701 4322 987 2745 4372 851 4002 3597 2496 4489 2858 3072 3348 M12866 GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ORGANIC_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. 1850/2715 Gene Ontology BP GO:0071310 3.54507462836493e-08 1.97691467186943e-07 3270 2630.27272727273 3072 3.54507468491892e-09 302 2.09166371470166 2.31343237695427 1 15.0204676228749 3269 2091 4391 1456 707 3342 3770 3072 2404 302 4129 3349 M16198 GO_ENDOTHELIAL_TUBE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_TUBE_MORPHOGENESIS.html The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 16/17 Gene Ontology BP GO:0061154 1.64239633423371e-06 2.15573205731719e-06 3330 2641.36363636364 3072 1.49308869123252e-07 504 1.97391776886281 -0.969089966468716 -1 11.9581257942673 3329 4030 3017 2211 3514 3281 3072 730 504 3889 1478 3350 M10571 GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_POTASSIUM_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. 14/23 Gene Ontology BP GO:1901017 1.82005392442667e-06 2.35634694222519e-06 3395 2717 3073 1.65459584559455e-07 1011 2.57147542159277 -2.57774264137993 -1 15.5051609321241 3392 1011 2225 2850 3563 3197 3073 3333 1933 1949 3361 3351 M11074 GO_CELLULAR_IRON_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_IRON_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. 44/63 Gene Ontology BP GO:0006879 2.09674791404365e-07 4.10267789909383e-07 2305 2994 3073 1.90613464897987e-08 2303 2.03984376858186 -2.30112144714163 -1 13.9475019651885 2303 3936 3073 3668 2335 2321 2368 3356 3211 3834 2529 3352 M11745 GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOTIC_G2_M_TRANSITION_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. 22/25 Gene Ontology BP GO:0044818 6.78769493285248e-07 1.01553519365153e-06 730 2122 3074 6.17063366097425e-08 132 1.36095988405761 1.63039526301824 1 8.68981329564501 728 3741 3465 3183 3074 648 132 567 3117 3595 1092 3353 M14052 GO_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_G2_M_PHASE_TRANSITION.html The cell cycle process by which a cell in G2 phase commits to M phase. 186/243 Gene Ontology BP GO:0044839 7.40419399912625e-07 1.09335813005187e-06 220 2393.45454545455 3075 6.73108771912777e-08 217 1.53362925992418 1.5870845307997 1 9.75359087420026 217 4102 3869 4256 3119 589 285 1145 3075 3880 1791 3354 M16432 GO_TEMPERATURE_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TEMPERATURE_HOMEOSTASIS.html A homeostatic process in which an organism modulates its internal body temperature. 22/35 Gene Ontology BP GO:0001659 5.16874135261329e-08 2.03786266205398e-07 3075 2867 3075 4.69885588549922e-09 1045 1.60849348287974 -1.58389100369649 -1 11.5017518253937 3075 1928 2607 3106 1045 3328 4256 3237 3196 2985 2774 3355 M10643 GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. 18/31 Gene Ontology BP GO:2001014 9.76751568370258e-06 1.12162513514976e-05 3080 3061.90909090909 3076 8.87959913599228e-07 1400 2.45640560721467 2.37239058822042 1 13.0099057651486 3076 4018 2378 4137 4026 2822 1400 2883 3358 3154 2429 3356 M11192 GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. 61/108 Gene Ontology BP GO:0051055 6.5212600334887e-08 2.16893659298234e-07 4020 3170.63636363636 3076 5.92841838799316e-09 1295 2.13130628689515 -1.69373362469404 -1 15.2146863025382 4019 3048 2005 3076 1295 4164 4515 2416 2886 3269 4184 3357 M13928 GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ASSEMBLY.html Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. 24/28 Gene Ontology BP GO:0010592 1.12793452240953e-06 1.55966696367654e-06 3605 3000.09090909091 3076 1.02539554609015e-07 1657 1.48164211934027 -1.24436358863496 -1 9.17244653661022 3603 2798 3086 1657 3332 3076 2480 4145 2457 2881 3486 3358 M14462 GO_CELLULAR_RESPONSE_TO_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_PH.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. 19/28 Gene Ontology BP GO:0071467 4.15733520744813e-07 6.82858990575346e-07 4125 3138.54545454545 3076 3.77939635732642e-08 876 1.37440991417993 -1.33716030480411 -1 9.03247884227794 4125 876 3026 3632 2794 3968 4443 3076 1612 2915 4057 3359 M15324 GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTI_ORGANISM_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. 151/255 Gene Ontology BP GO:0043901 6.80646490169456e-07 1.01736206834516e-06 1820 2916.54545454545 3077 6.1876972795564e-08 1820 1.94444496751774 -1.95540901049419 -1 12.4622521697925 1820 3615 2565 3168 3077 2523 3508 3428 3875 1976 2527 3360 M16224 GO_TRANSCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCYTOSIS.html The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. 11/12 Gene Ontology BP GO:0045056 9.35077604012165e-06 1.07722606869735e-05 3080 2956.09090909091 3078 8.5007416222316e-07 1887 4.70142343137962 -4.59314895351686 -1 25.0926006285252 3078 4291 1887 2120 4013 3774 3504 1918 2233 3348 2351 3361 M11689 GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. 239/337 Gene Ontology BP GO:0016053 5.77956015411893e-08 2.07580109259326e-07 3680 2714.45454545455 3079 5.25414573268379e-09 565 2.29333216834174 2.19870986510416 1 16.4271100090097 3677 1427 565 3854 1180 4325 4144 3079 2402 856 4350 3362 M10796 GO_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. 1260/1734 Gene Ontology BP GO:0051336 2.83740345769715e-08 1.97691467186943e-07 3380 2502.90909090909 3080 2.83740349392601e-09 287 2.05989600362188 2.25888926018428 1 14.7906224872457 3376 1156 4263 1095 453 3080 3603 3570 2496 287 4153 3363 M11042 GO_POSITIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TOR_SIGNALING.html Any process that activates or increases the frequency, rate or extent of TOR signaling. 29/31 Gene Ontology BP GO:0032008 5.57000231832269e-07 8.62469909722313e-07 3075 3028.90909090909 3080 5.06363975322463e-08 250 1.93832100903986 -0.771361444986066 -1 12.5727016639919 3071 4192 3080 3939 2968 2130 1981 3691 250 4252 3764 3364 M12781 GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 469/577 Gene Ontology BP GO:0009896 8.94304241553377e-08 2.47114530749848e-07 2780 3072 3080 8.13003889006378e-09 1612 1.52688395677039 -1.34493125057464 -1 10.7744890966916 2776 3589 4102 4467 1612 1840 3080 3411 2409 4427 2079 3365 M11546 GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that activates or increases the rate or extent of B cell proliferation. 35/57 Gene Ontology BP GO:0030890 6.7757302698752e-08 2.19879876316322e-07 4380 3278.81818181818 3082 6.15975498050853e-09 1338 2.04124110596391 -1.85686903118174 -1 14.553879014337 4379 2740 1963 4105 1338 4545 3082 2939 4254 2303 4419 3366 M13643 GO_NOTCH_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOTCH_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 105/151 Gene Ontology BP GO:0007219 3.03157147491323e-07 5.34516940991712e-07 4190 3173.09090909091 3084 2.75597444787267e-08 1540 2.17798360699181 -1.60058930086398 -1 14.6296328895446 4187 2644 1540 2787 2600 3977 3918 4262 2669 3084 3236 3367 M15153 GO_REGULATION_OF_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CILIUM_MOVEMENT.html Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. 14/27 Gene Ontology BP GO:0003352 1.10945987727207e-05 1.26744827128577e-05 1545 2651 3085 1.00860497483374e-06 816 1.51496759522199 -1.39006965157702 -1 7.89361489656201 1545 3811 3085 4403 4049 1586 1579 816 4098 3367 822 3368 M12879 GO_REGULATION_OF_EXCRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXCRETION.html Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. 15/33 Gene Ontology BP GO:0044062 8.87822970339963e-08 2.46335138997725e-07 4430 2917.54545454545 3086 8.07111823789621e-09 533 2.60142798195783 -2.76461916564107 -1 18.4404760169866 4426 2495 1045 2114 1605 4244 3996 3086 4123 533 4426 3369 M11278 GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRIGLYCERIDE_LIPASE_ACTIVITY.html Any process that increases the activity of triglyceride lipase. 4/15 Gene Ontology BP GO:0061365 4.32961347840107e-06 5.1881770576874e-06 1270 2507.72727272727 3087 4.32962191392299e-07 423 1.70668470135734 -1.70668470135734 -1 9.62135809888077 1269 4083 4291 3452 3883 1024 423 1079 4090 3087 904 3370 M12849 GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METANEPHRIC_RENAL_VESICLE_MORPHOGENESIS.html The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. 4/14 Gene Ontology BP GO:0072283 2.85268165653626e-05 3.12391803903583e-05 2920 3214.27272727273 3089 2.85271827726474e-06 2395 1.56857294285721 1.63366088505654 1 7.51371490983743 2920 2587 4390 2395 4248 2556 3503 4044 2444 3089 3181 3371 M14604 GO_FUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FUCOSE_METABOLIC_PROCESS.html The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. 11/15 Gene Ontology BP GO:0006004 4.42455360189619e-07 7.16085144682538e-07 3345 2770.09090909091 3089 4.02232226522299e-08 1062 1.26031104745928 -1.56297586025014 -1 8.24517879019301 3345 1062 3094 3089 2839 3090 2352 1142 4034 3345 3079 3372 M13269 GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PEPTIDYL_THREONINE_PHOSPHORYLATION.html Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. 17/18 Gene Ontology BP GO:0010801 7.02608809979221e-07 1.04615641370666e-06 885 2738 3090 6.38735485790764e-08 881 0.952897974126795 1.07663300858585 1 6.03713414739647 881 4253 3755 4014 3090 1099 958 1786 4485 4120 1677 3373 M11081 GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_NF_KAPPAB_INDUCING_KINASE_ACTIVITY.html The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. 21/35 Gene Ontology BP GO:0007250 5.67312270058041e-06 6.69635716027413e-06 3605 3187.36363636364 3091 5.1573975726092e-07 2442 1.89460593094541 -1.63053690619972 -1 10.466605126928 3601 2816 2614 2567 3915 3835 4073 3398 3091 2442 2709 3374 M15783 GO_RESPONSE_TO_CYTOKINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CYTOKINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. 706/1023 Gene Ontology BP GO:0034097 1.04077575919393e-07 2.63908970437567e-07 2650 2998.54545454545 3091 1.04077580793857e-08 964 2.04526461368191 -1.87638717095605 -1 14.4078183788486 2650 3296 4571 3302 1853 2649 3316 4218 3074 964 3091 3375 M11767 GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. 153/223 Gene Ontology BP GO:0043433 6.61071627122689e-08 2.17810395517477e-07 2505 2935.36363636364 3093 6.00974224533672e-09 1311 1.66000248122692 -1.54508958918217 -1 11.8219139369513 2501 2193 3181 3658 1311 2274 3352 4628 3093 3393 2705 3376 M16412 GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of astrocyte differentiation. 13/15 Gene Ontology BP GO:0048711 1.72647832160596e-05 1.9329412007778e-05 3095 2894.18181818182 3093 1.56953806410518e-06 821 1.79292671466578 -2.2241622813156 -1 9.00798888289741 3093 3227 2700 2595 4134 4322 4114 821 2294 3240 1296 3377 M11562 GO_DNA_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEALKYLATION.html The removal of an alkyl group from one or more nucleotides within an DNA molecule. 17/20 Gene Ontology BP GO:0035510 1.79414077337597e-06 2.32668255811549e-06 3355 3069.27272727273 3094 1.6310383968479e-07 1947 1.25248882841465 1.63456676019318 1 7.50152666158723 3353 3503 3457 3094 3557 2969 1947 2559 2673 4119 2531 3378 M12519 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. 24/27 Gene Ontology BP GO:0031112 5.73693106866126e-05 6.15493204115306e-05 1460 2783 3094 5.2155278871288e-06 721 1.35672329685729 1.494808917589 1 6.05239948251854 1459 4492 3728 4439 4321 1426 721 1843 3094 4334 756 3379 M11035 GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. 23/36 Gene Ontology BP GO:0045686 3.90284917166538e-07 6.52063095000324e-07 4515 2909.72727272727 3095 3.5480453309452e-08 575 2.5578310022526 -1.82196931069526 -1 16.9625047151098 4515 1933 1971 1088 2750 4155 4012 3703 575 3095 4210 3380 M13829 GO_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENETIC_IMPRINTING.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 20/23 Gene Ontology BP GO:0071514 7.11456231990906e-07 1.05729985546269e-06 1905 2855.63636363636 3096 6.46778601880244e-08 1127 1.66043753617053 1.57345037297009 1 10.5955180366184 1901 3747 3128 3974 3096 1833 1951 2781 4192 3682 1127 3381 M13947 GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process. 26/38 Gene Ontology BP GO:0070229 8.96025250710917e-07 1.28475483276248e-06 4505 3038.09090909091 3096 8.14568741498233e-08 1395 2.46813156529119 -2.66818211350849 -1 15.5791510865415 4504 2785 1718 3096 3213 4546 3750 2436 1422 1395 4554 3382 M16401 GO_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_APOPTOTIC_PROCESS.html Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. 15/19 Gene Ontology BP GO:0070231 7.07474477512946e-06 8.26274785107363e-06 2370 3169.63636363636 3096 6.43160684195197e-07 2369 1.06544615280301 1.09204138762962 1 5.73151293408051 2369 3792 3702 2658 3958 2762 2430 2622 4000 3477 3096 3383 M10897 GO_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 45/54 Gene Ontology BP GO:0090311 1.88569253143591e-07 3.82148403692128e-07 3100 3013.63636363636 3098 1.71426608460441e-08 2042 1.59067138572375 2.04486724678362 1 10.9043014623244 3098 3388 3269 2042 2255 3568 2747 3091 3373 3311 3008 3384 M11395 GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that modulates the frequency, rate or extent of intracellular signal transduction. 1666/2243 Gene Ontology BP GO:1902531 3.76165961945029e-08 1.97691467186943e-07 3240 2490 3098 3.76165968312566e-09 267 1.97936471962262 2.21116522895905 1 14.2079640814598 3239 1140 4296 1459 766 3098 3405 3418 2298 267 4004 3385 M13277 GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. 34/50 Gene Ontology BP GO:0071825 4.0737377832605e-08 1.97691467186943e-07 4270 2792.45454545455 3098 3.70339805335806e-09 756 2.59095930992986 -2.04413531832013 -1 18.6329615641641 4268 3098 1485 3604 756 3485 3128 2986 2859 1869 3179 3386 M11752 GO_PURINE_CONTAINING_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_SALVAGE.html Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. 16/17 Gene Ontology BP GO:0043101 2.51478995530939e-07 4.6250267438951e-07 2490 3026.27272727273 3099 2.28617294797422e-08 2133 1.4033865818781 1.30498143110363 1 9.48158710498812 2133 4021 3337 3671 2488 2488 2728 2724 3347 3253 3099 3387 M14790 GO_PEPTIDYL_PROLINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_PROLINE_MODIFICATION.html The modification of peptidyl-proline. 47/55 Gene Ontology BP GO:0018208 5.01105510402176e-05 5.38859241946227e-05 1010 2670.54545454545 3099 4.55560840644138e-06 554 1.86136458787785 2.04315004145554 1 8.46169931640895 1007 3927 3099 3859 4401 2110 3101 554 2265 3453 1600 3388 M11040 GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. 26/31 Gene Ontology BP GO:0045606 4.79381594130325e-05 5.16214431263226e-05 3135 2871.45454545455 3100 4.35810945644243e-06 1257 1.66983973115775 -1.47832452405034 -1 7.61299806044788 3060 3132 3100 3731 4304 2122 2666 1305 3778 3131 1257 3389 M12761 GO_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_MODIFICATION.html The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure. 524/725 Gene Ontology BP GO:0016568 5.76476950275903e-07 8.87900446750671e-07 1565 3248.72727272727 3101 5.76477099822509e-08 1563 1.42236503756187 1.45448256886419 1 9.17653306132454 1563 4323 4388 4332 3042 2006 2031 3374 3101 4575 3001 3390 M14956 GO_REGULATION_OF_FATTY_ACID_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid oxidation. 34/43 Gene Ontology BP GO:0046320 2.51053391095657e-07 4.62205675240452e-07 4160 3490.18181818182 3101 2.28230381586058e-08 2484 1.74279151936308 -1.41158648462778 -1 11.802558256074 4156 3101 3012 2897 2484 4635 3988 4033 2944 2834 4308 3391 M11024 GO_HEME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_METABOLIC_PROCESS.html The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. 28/37 Gene Ontology BP GO:0042168 1.26491678953071e-07 2.93105480790615e-07 2195 2699.63636363636 3102 1.14992442023513e-08 379 1.65619307624312 -0.867343324473166 -1 11.5640463291165 2191 3120 3102 3376 1943 2503 2220 3556 379 3805 3501 3392 M11424 GO_RESPONSE_TO_COPPER_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COPPER_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. 33/42 Gene Ontology BP GO:0046688 2.77053613904069e-07 4.97731305171957e-07 4580 3135.90909090909 3103 2.51866953449451e-08 1803 1.88332292411729 -1.83560916395559 -1 12.698020929943 4577 2348 1803 3293 2546 3652 3103 3856 2545 2708 4064 3393 M15098 GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_INVOLVED_IN_ENDOCARDIAL_CUSHION_FORMATION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion. 15/16 Gene Ontology BP GO:0003198 4.71846817536211e-05 5.08453738303842e-05 3105 3176.18181818182 3103 4.28960852557901e-06 1715 2.72439643454189 -2.92987177407575 -1 12.5116153846946 3103 3794 1715 3361 4300 4120 4522 2414 2934 2698 1977 3394 M11294 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 17/18 Gene Ontology BP GO:0033145 0.000495450616239488 0.000511386805093687 4315 3190.72727272727 3104 4.50511117546181e-05 63 2.30777105993103 -1.66761165910595 -1 8.08415388386447 4312 4031 2892 2607 4495 3659 3104 2848 63 4117 2970 3395 M14059 GO_NEGATIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BINDING.html Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 174/229 Gene Ontology BP GO:0051100 6.43313511978503e-07 9.69345133172272e-07 2845 3101.54545454545 3105 5.84830636448409e-08 2349 1.72103085254486 2.1467590154637 1 11.0563611940249 2845 3874 3105 3197 3052 3338 2423 2759 3457 3718 2349 3396 M11195 GO_VESICLE_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_TARGETING.html The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. 110/125 Gene Ontology BP GO:0006903 2.83069724920376e-08 1.97691467186943e-07 4540 2882.18181818182 3106 2.57336116875072e-09 368 2.00025696372608 -1.23256021632232 -1 14.3591232464214 4539 1620 2668 2159 368 3929 3106 4143 668 3981 4523 3397 M14885 GO_LATERAL_VENTRICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_VENTRICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. 26/49 Gene Ontology BP GO:0021670 1.93902090635141e-07 3.89899061246893e-07 3420 2985.63636363636 3108 1.76274643386502e-08 2047 2.04813989895181 2.2674422562468 1 14.0535709018324 3215 3444 2349 3656 2275 3108 2971 2047 2940 3420 3417 3398 M11248 GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD.html The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). 34/61 Gene Ontology BP GO:0043153 1.25071255775611e-07 2.91415399661451e-07 4035 2962 3109 1.13701148078167e-08 1633 1.99520676713329 2.58290474628658 1 13.9597018898415 4031 3418 2640 3691 1934 2916 1633 3493 1886 3109 3831 3399 M13093 GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. 33/45 Gene Ontology BP GO:1904037 3.68535948196401e-07 6.24537636301784e-07 3590 3073.72727272727 3112 3.35032736302008e-08 1457 2.90577510054833 -3.0281047812581 -1 19.344055085979 3590 3112 1457 1909 2712 4393 4526 3454 3554 2381 2723 3400 M16299 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_HORMONE.html The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. 24/57 Gene Ontology BP GO:0001990 2.34819829154247e-07 4.41501657983249e-07 4155 3051.90909090909 3114 2.1347259474368e-08 1497 2.34029721755031 -2.12848712781358 -1 15.9380392535777 4151 3136 1497 3114 2427 3938 4412 2355 3836 1746 2959 3401 M13591 GO_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. 105/157 Gene Ontology BP GO:0006633 4.94777018963365e-08 2.01774734543894e-07 2985 3017.72727272727 3115 4.49797300082577e-09 998 2.11019097511589 -2.5008076801018 -1 15.1342951245882 2983 3888 1827 3920 998 2993 3573 3808 3904 2186 3115 3402 M13592 GO_HEART_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEART_FORMATION.html The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. 13/18 Gene Ontology BP GO:0060914 1.65290598801541e-06 2.16769209758617e-06 3455 2445.36363636364 3116 1.50264293625413e-07 206 3.34776186179449 3.50627300503681 1 20.3509995875685 3451 996 1308 795 3517 3116 3361 3745 206 2271 4133 3403 M13757 GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_TRANSCRIPTION_FACTOR.html The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. 19/22 Gene Ontology BP GO:0042994 1.22857835325797e-06 1.6803571656994e-06 3425 2973.27272727273 3116 1.11689003577417e-07 1967 1.23016852169841 -1.14068623593511 -1 7.55347046913687 2322 1967 3424 3424 3367 3043 3178 2582 2421 3862 3116 3404 M15573 GO_RESPONSE_TO_FUNGUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. 33/132 Gene Ontology BP GO:0009620 9.52121062380726e-07 1.3515007026411e-06 4560 3039.09090909091 3117 8.65564976765564e-08 905 3.1759754868404 -3.52636001655619 -1 20.0041911384519 4556 3952 905 3879 3245 3117 2317 2600 2983 1726 4150 3405 M11034 GO_C21_STEROID_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 25/43 Gene Ontology BP GO:0008207 5.25425954506749e-08 2.04581932255101e-07 3120 2905.45454545455 3118 4.77659970050451e-09 1067 2.08583536029482 -1.88225549632574 -1 14.9448035283622 3118 3127 2116 3362 1067 3009 3204 4399 3839 2281 2438 3406 M12901 GO_G1_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_G1_DNA_DAMAGE_CHECKPOINT.html A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage. 88/99 Gene Ontology BP GO:0044783 7.40159006480465e-07 1.09332058957257e-06 1760 2892 3118 6.72872050451504e-08 1665 1.72925076171515 1.91374952573105 1 11.0121604406413 1760 3892 3360 3768 3118 1665 1688 3341 2941 3774 2505 3407 M13628 GO_DNA_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_STRAND_ELONGATION.html The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand. 30/31 Gene Ontology BP GO:0022616 0.000143942693315684 0.000150780133272823 345 2615.18181818182 3118 1.30865556484118e-05 100 0.945605837815659 0.935252942710826 1 3.78700757256448 341 3118 3821 3211 4427 915 100 1864 4261 4175 2534 3408 M12758 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA.html Any process that modulates the frequency, rate or extent of cellular response to hypoxia. 15/15 Gene Ontology BP GO:1900037 2.05494871974693e-05 2.28529550501493e-05 2835 3035.63636363636 3119 1.86815264964375e-06 1750 2.42064486752061 2.73649288859405 1 12.0113690250989 2834 3807 2735 3439 4163 3401 3311 1750 1924 3119 2909 3409 M13724 GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of heart contraction. 39/57 Gene Ontology BP GO:0045823 1.16744672952782e-06 1.60381742913874e-06 3545 3010 3119 1.06131577185705e-07 1446 2.433887874035 2.3894104849382 1 15.1083865135841 3541 3407 1446 2862 3352 2953 2895 4168 3742 1625 3119 3410 M14831 GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that activates or increases the frequency, rate or extent of chromosome organization. 165/184 Gene Ontology BP GO:2001252 1.27480563903352e-06 1.73238044346465e-06 1380 2922.63636363636 3119 1.15891488884482e-07 1376 1.63005949111535 1.69502129143309 1 10.0223474281947 1376 4111 3894 3587 3390 1931 1478 1971 3119 4415 2877 3411 M15949 GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BLOOD_VOLUME_BY_RENIN_ANGIOTENSIN.html The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. 9/16 Gene Ontology BP GO:0002016 1.93815373802874e-07 3.8989318387582e-07 3180 3275.45454545455 3120 1.93815390706855e-08 2353 1.89166905458899 -2.31162729745016 -1 12.971299509043 3179 2952 4582 4112 2353 4174 3692 2620 2807 2439 3120 3412 M14518 GO_DNA_METHYLATION_OR_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION_OR_DEMETHYLATION.html The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. 47/65 Gene Ontology BP GO:0044728 6.2715180640725e-07 9.48370931170925e-07 2520 3278.45454545455 3121 5.70138168353511e-08 2287 1.10192781948337 1.32842311912122 1 7.04969176221711 2518 3387 3907 4164 3038 2830 2818 3121 3622 4371 2287 3413 M12133 GO_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of vacuolar transport. 37/40 Gene Ontology BP GO:1903335 2.54282126076236e-08 1.97691467186943e-07 3430 2728.81818181818 3122 2.31165571832091e-09 274 1.5825102959958 2.13045324469751 1 11.3366505456966 3429 1812 3122 2016 274 4326 4611 4098 1147 3138 2044 3414 M16332 GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. 51/56 Gene Ontology BP GO:1904031 7.44330527639026e-07 1.09758204435186e-06 2320 2891.81818181818 3122 6.7666434497275e-08 760 2.04390613782876 1.78112414720616 1 13.0327915403905 2320 4162 3169 2222 3122 1971 760 2655 3601 4169 3659 3415 M12033 GO_B_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_MEDIATED_IMMUNITY.html Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. 57/269 Gene Ontology BP GO:0019724 2.78236282818611e-07 4.99087673074402e-07 3995 3041.18181818182 3123 2.52942107279499e-08 1740 2.18172089016004 -2.66833429338014 -1 14.7250608416755 3992 3658 1812 3882 2549 3123 2613 3787 3508 1740 2789 3416 M14306 GO_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JNK_CASCADE.html Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade. 203/282 Gene Ontology BP GO:0046328 4.55377797165221e-07 7.3393588161059e-07 4255 3322.27272727273 3124 4.13979901294415e-08 2212 1.81504394779857 1.98523432181086 1 11.9031736506143 4253 2998 2603 2212 2851 4189 3131 4118 3124 2531 4535 3417 M14587 GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. 15/26 Gene Ontology BP GO:0032924 2.0033233845529e-07 3.97760141854629e-07 3595 2998.45454545455 3124 1.82120324270533e-08 1537 1.78526229977885 1.81852070648734 1 12.2185841916316 3594 3206 2593 3054 2302 3583 2863 3304 1537 3124 3823 3418 M10872 GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_SYSTEM_PROCESS_INVOLVED_IN_REGULATION_OF_BLOOD_VOLUME.html A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. 13/33 Gene Ontology BP GO:0001977 1.28368249225693e-07 2.96131613112121e-07 4610 3059.36363636364 3125 1.16698415196253e-08 1805 1.98403020242801 -1.63625665747569 -1 13.8659409550542 4608 3223 2360 3125 1954 4135 4174 1805 2524 2265 3480 3419 M14606 GO_APOPTOTIC_DNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_DNA_FRAGMENTATION.html The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. 15/18 Gene Ontology BP GO:0006309 2.17392256096743e-06 2.76599991145241e-06 3245 2688.18181818182 3125 1.9762951901133e-07 664 1.84577331565118 -2.49245536561784 -1 10.9588254513224 3242 3209 3030 2553 3627 3719 4311 1037 664 3125 1053 3420 M15990 GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. 111/167 Gene Ontology BP GO:0072593 3.9850738973311e-08 1.97691467186943e-07 3880 2850.72727272727 3126 3.62279451774238e-09 732 2.34631076191113 -2.30963994053534 -1 16.8628850685785 3876 2642 1386 3865 732 3216 3247 3921 3126 2243 3104 3421 M16557 GO_ENDOCRINE_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PROCESS.html The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. 35/73 Gene Ontology BP GO:0050886 5.03410517900716e-07 7.94023437217638e-07 4415 3207.18181818182 3127 4.57646030084217e-08 1687 2.22614668180601 -1.99428745022187 -1 14.542720994844 4415 3100 1687 3127 2916 4147 3625 3205 3713 2305 3039 3422 M11970 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_SECRETION.html Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell. 16/37 Gene Ontology BP GO:0050716 1.57005319424318e-05 1.76716437174976e-05 3130 3102.63636363636 3128 1.4273312720048e-06 2129 2.02074502044075 1.63739753649078 1 10.2518861793202 3128 3517 2129 3689 4110 3001 2172 2331 4279 2395 3378 3423 M10636 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. 53/89 Gene Ontology BP GO:0032757 9.6598949919992e-07 1.36618514886846e-06 3130 3239.63636363636 3129 8.78172657593434e-08 2064 1.85796324447906 1.89178707711585 1 11.6462168191287 3129 3665 2315 2999 3254 2935 3044 4259 4020 2064 3952 3424 M10886 GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 172/209 Gene Ontology BP GO:0031330 7.25725923326285e-08 2.2546006802268e-07 3725 2942.63636363636 3129 6.59750861151093e-09 1404 1.58331069682043 -1.43581460008701 -1 11.2449027207099 3724 2181 3561 2022 1404 3129 4319 3758 2002 3959 2310 3425 M11700 GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. 17/33 Gene Ontology BP GO:0002675 5.09123674894155e-07 8.00862900365958e-07 3605 2959.45454545455 3129 4.62839811559563e-08 942 2.08777044184585 -3.04056756402148 -1 13.6233293435405 3602 942 1327 3084 2924 4470 4426 3673 3972 1005 3129 3426 M14432 GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BLOOD_PRESSURE.html Any process in which the force of blood traveling through the circulatory system is increased. 29/50 Gene Ontology BP GO:0045777 7.47996630128828e-07 1.1011846753279e-06 4090 2850.18181818182 3129 6.7999716767878e-08 842 2.41285213002895 -2.07066805992621 -1 15.4020532300449 4088 3435 1649 3112 3129 4561 3749 842 4105 1225 1457 3427 M15732 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY.html Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. 16/17 Gene Ontology BP GO:0010715 0.00135292535729921 0.00138721059663138 2160 3044.54545454545 3130 0.000123068916137455 1566 2.47896109251789 2.99431082535139 1 7.53273695380111 2157 4034 2244 3946 4530 1794 1566 3766 3130 3264 3059 3428 M12487 GO_LIPOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPOXYGENASE_PATHWAY.html The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. 10/15 Gene Ontology BP GO:0019372 7.48564165452534e-07 1.10153986775795e-06 2615 2897.45454545455 3131 6.8051310923312e-08 1565 1.95516936042787 -2.14262704761599 -1 12.4587604162015 2615 2073 1874 3410 3131 3150 3590 3927 3800 1565 2737 3429 M12920 GO_APOPTOTIC_NUCLEAR_CHANGES http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_NUCLEAR_CHANGES.html Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. 26/32 Gene Ontology BP GO:0030262 4.56795025371147e-06 5.45551142980479e-06 3135 2914.81818181818 3131 4.15269067123777e-07 1862 1.48677113486137 -1.86880287527267 -1 8.33201934616984 3352 3131 3316 3392 3870 3031 2849 2203 1862 3132 1925 3430 M16503 GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that modulates the frequency, rate or extent of response to DNA damage stimulus. 175/203 Gene Ontology BP GO:2001020 1.07618879802397e-07 2.67781095037728e-07 2145 3100.54545454545 3134 9.7835350060784e-09 1406 1.62998469989472 1.74103750258636 1 11.4482970984414 2143 4649 3589 4444 1802 2185 1406 3134 2919 3748 4087 3431 M14645 GO_LEUKOCYTE_CELL_CELL_ADHESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_CELL_CELL_ADHESION.html The attachment of a leukocyte to another cell via adhesion molecules. 255/415 Gene Ontology BP GO:0007159 5.58109182915873e-08 2.05617623085131e-07 4245 2590 3136 5.07371997340292e-09 297 2.1407681113044 -1.90582239579414 -1 15.3363029856651 4243 1402 577 924 1138 4276 4158 3799 3136 297 4540 3432 M16182 GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-alpha production. 34/57 Gene Ontology BP GO:0032647 9.85743356139208e-06 1.13139216480408e-05 4260 3452.63636363636 3136 8.96134339035889e-07 2677 1.69266676109574 -1.55267350803844 -1 8.92285916670546 4256 3104 2677 2972 4027 4152 3136 2969 3645 3111 3930 3433 M13027 GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION.html Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. 23/34 Gene Ontology BP GO:0060142 1.11607375555867e-07 2.73464517357268e-07 3590 3211.09090909091 3137 1.01461255652527e-08 1831 2.20501839369189 1.47201699511963 1 15.5052748616111 3589 3137 1988 2756 1831 3524 3959 4647 3088 2362 4441 3434 M16900 GO_QUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving quinone. 32/46 Gene Ontology BP GO:1901661 6.86212260348342e-08 2.20507296091218e-07 2525 3096.18181818182 3137 6.23829347047555e-09 1354 1.47031204191688 -1.75872115995785 -1 10.4496056292977 2524 3960 3268 3982 1354 2275 2634 3137 4119 4115 2690 3435 M11027 GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_LAYER_FORMATION.html The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. 14/25 Gene Ontology BP GO:0021694 1.23455116939908e-06 1.68505913499969e-06 3145 2976.54545454545 3141 1.12231987470899e-07 1000 3.13964387394851 3.68838197674065 1 19.4494540180087 3141 4036 1995 3642 3373 3608 3763 1000 2905 2949 2330 3436 M13558 GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. 1384/2007 Gene Ontology BP GO:1901700 1.09571325451815e-13 4.39513256316632e-12 3375 2370.45454545455 3141 1.0957132545182e-14 22 2.22842198936121 2.43359705189329 1 27.2003634777942 3375 1152 4435 22 396 3141 3585 3855 2165 56 3893 3437 M13708 GO_ORGANELLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. 547/698 Gene Ontology BP GO:0070925 4.1272453731623e-08 1.97691467186943e-07 3110 2773 3141 4.12724544981598e-09 907 1.76825554529894 1.8592738002068 1 12.6805510209735 3106 2119 4445 2068 907 3183 3569 3231 1114 3141 3620 3438 M14696 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ORGANIZATION.html The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. 12/33 Gene Ontology BP GO:0034723 0.000120961164522706 0.000127337624100486 2600 3150.27272727273 3141 1.0997074160316e-05 1822 1.86467726226479 1.08235298403684 1 7.72535904497773 2596 2546 2366 3141 4405 3303 4141 1822 3907 2562 3864 3439 M16272 GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. 23/30 Gene Ontology BP GO:0032332 7.55250567350168e-07 1.10702955970865e-06 4085 3084.81818181818 3141 6.86591660567796e-08 1617 2.18839321354602 -1.67252424599135 -1 13.9533049168578 4081 3138 2353 2340 3141 3279 3387 4090 2350 1617 4157 3440 M13019 GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBELLAR_PURKINJE_CELL_DIFFERENTIATION.html The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. 14/25 Gene Ontology BP GO:0021702 1.23455116939908e-06 1.68505913499969e-06 3145 2967.27272727273 3142 1.12231987470899e-07 884 3.13964387394851 3.68838197674065 1 19.4494540180087 3142 4037 1996 3643 3374 3609 3764 884 2906 2954 2331 3441 M14852 GO_MISMATCH_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISMATCH_REPAIR.html A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. 30/34 Gene Ontology BP GO:0006298 2.89248104303361e-05 3.16601136044117e-05 1115 2727.18181818182 3142 2.62956279366934e-06 864 1.61702598407803 1.91770414159809 1 7.73916204316441 1113 3715 3142 4031 4230 1558 864 2130 3530 3541 2145 3442 M15799 GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_DEPENDENT_NUCLEOSOME_ASSEMBLY.html The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. 12/33 Gene Ontology BP GO:0006335 0.000120961164522706 0.000127337624100486 2600 3139.18181818182 3142 1.0997074160316e-05 1688 1.86467726226479 1.08235298403684 1 7.72535904497773 2597 2547 2367 3142 4406 3304 4142 1688 3908 2565 3865 3443 M12716 GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHEMOKINE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 25/81 Gene Ontology BP GO:0070098 7.5562559244244e-07 1.10702955970865e-06 3115 2761.09090909091 3143 6.86932592703998e-08 557 3.38523572429709 -3.22848296165766 -1 21.6462864609642 3113 2782 557 1496 3143 3732 4014 3685 3804 638 3408 3444 M15796 GO_MICROVILLUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROVILLUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. 27/31 Gene Ontology BP GO:0032528 9.27761963745285e-06 1.06906300577187e-05 3060 3182.27272727273 3143 8.43423523848371e-07 2388 1.27503586814736 1.39448905507617 1 6.72728630461148 3057 2388 3490 3143 4012 3832 3182 2430 3072 3529 2870 3445 M10448 GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MACROPHAGE_ACTIVATION.html Any process that stimulates, induces or increases the rate of macrophage activation. 11/16 Gene Ontology BP GO:0043032 2.09401253570515e-06 2.67824088197803e-06 2330 2859.81818181818 3145 1.90364957167177e-07 938 2.21104212766041 -2.55999127207685 -1 13.1833138880177 4231 3254 1961 1977 3606 4096 3145 938 2330 2330 3590 3446 M11436 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor. 24/31 Gene Ontology BP GO:0010804 0.000506767649372706 0.000522488338695147 1055 2479.81818181818 3148 4.60804018562118e-05 346 1.34074506438669 -1.29557243008625 -1 4.63576106507529 1051 3148 3327 3164 4500 979 346 1661 4169 3518 1415 3447 M10603 GO_MICROTUBULE_ANCHORING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_ANCHORING.html Any process in which a microtubule is maintained in a specific location in a cell. 22/22 Gene Ontology BP GO:0034453 2.69716854305874e-07 4.87754575625818e-07 4455 3142.54545454545 3150 2.45197170338891e-08 409 1.49574725650872 -1.13746107669977 -1 10.0757707846805 4451 3150 3137 3420 2531 4172 3041 2338 409 3593 4326 3448 M12905 GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION_VISIBLE_LIGHT.html The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. 17/35 Gene Ontology BP GO:0007603 1.41919802687444e-07 3.15053836786582e-07 3150 3209.45454545455 3150 1.29018010765954e-08 2040 1.93208096588161 1.9202867197444 1 13.4438272321583 3150 2868 2352 4107 2040 3425 4558 2171 4323 2595 3715 3449 M16711 GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEVELOPMENTAL_PIGMENTATION.html Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. 21/23 Gene Ontology BP GO:0048070 2.47613426601484e-05 2.72826254789653e-05 4465 3096.72727272727 3151 2.25105648702802e-06 1019 2.60962360713851 -2.37246416040895 -1 12.7412175267151 4462 3151 1743 2518 4200 4492 4421 1775 1019 2449 3834 3450 M16928 GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. 1656/2274 Gene Ontology BP GO:0006357 1.03421595823001e-07 2.62818506479751e-07 2410 3263.09090909091 3151 1.03421600636213e-08 1851 1.72093066291354 1.8421358027187 1 12.1084604848962 2409 4085 4651 4269 1851 2493 2443 2947 3151 4152 3443 3451 M12098 GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. 18/26 Gene Ontology BP GO:0002068 0.00273555427553011 0.00278889878265592 3005 3091.27272727273 3152 0.000248996517200067 442 2.13412410907125 -1.98863378739994 -1 5.77061716415983 3004 4019 2740 3132 4553 3152 3583 2877 442 3157 3345 3452 M15012 GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 101/120 Gene Ontology BP GO:0071158 1.3492011214807e-06 1.81650255157688e-06 625 2420 3152 1.22654722628214e-07 613 1.53721268415227 1.61910255746534 1 9.41087753891985 621 3350 3381 3778 3424 613 903 1788 3152 4054 1556 3453 M15301 GO_MITOCHONDRION_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_MORPHOGENESIS.html The process in which the anatomical structures of a mitochondrion are generated and organized. 28/37 Gene Ontology BP GO:0070584 3.46245964327241e-08 1.97691467186943e-07 3080 2884.90909090909 3152 3.14769063433288e-09 433 2.00327377191157 -1.25827941901122 -1 14.3809503993069 3080 3123 3112 3904 572 3335 3611 3604 433 3808 3152 3454 M10463 GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation. 18/22 Gene Ontology BP GO:0033599 2.16182440697647e-07 4.18426329686419e-07 4655 3187.81818181818 3153 1.96529510855238e-08 1332 1.53435227918302 1.93216656154174 1 10.4489991477586 4651 4010 3071 3443 2362 4441 3033 2276 1332 3153 3294 3455 M12217 GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. 412/567 Gene Ontology BP GO:0044283 3.43460460134853e-08 1.97691467186943e-07 3265 2366.90909090909 3153 3.12236786815366e-09 559 2.09408024378234 -2.07658784674248 -1 15.037951647862 3264 1312 809 3262 559 3153 3751 3351 1988 1207 3380 3456 M10364 GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. 56/86 Gene Ontology BP GO:0048641 1.23434494756007e-06 1.68505913499969e-06 3790 2996 3155 1.1221324000995e-07 378 1.82082796062866 -1.45512047304345 -1 11.2321511893245 3790 378 2780 3693 3372 3271 2343 4323 3155 2886 2965 3457 M15483 GO_CELL_CELL_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CELL_RECOGNITION.html Cell recognition between cells. May involve the formation of specialized cell junctions. 60/135 Gene Ontology BP GO:0009988 9.03351469387784e-07 1.29279824861741e-06 4165 2845.63636363636 3157 8.21228945742757e-08 1223 2.4396548455221 2.6788850659716 1 15.3909610177948 4161 2276 1508 1223 3219 3665 3157 3619 1321 2524 4629 3458 M14788 GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 22/27 Gene Ontology BP GO:0090322 2.34933529930763e-05 2.59442883891186e-05 3665 3165.36363636364 3162 2.1357821706882e-06 2408 2.32180944711826 2.94522658046453 1 11.3782581833917 3662 3162 2408 2624 4191 3173 3336 3761 3157 2586 2759 3459 M14763 GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEUROMUSCULAR_PROCESS_CONTROLLING_POSTURE.html Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. 18/43 Gene Ontology BP GO:0050884 3.3517353023195e-06 4.09441437692114e-06 4120 2898 3164 3.04703673522991e-07 332 2.44340799026142 -2.1142901222558 -1 14.0945677618115 4117 3164 1739 2746 3782 4069 3875 1080 332 2325 4649 3460 M12246 GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that modulates the frequency, rate or extent of a response to an external stimulus. 941/1381 Gene Ontology BP GO:0032101 4.13350356779764e-08 1.97691467186943e-07 3420 2670.18181818182 3165 4.13350364468397e-09 273 2.17645928523336 -1.96452482740291 -1 15.6339789130235 3419 1188 4357 1461 911 3189 4043 4619 2747 273 3165 3461 M15465 GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 27/29 Gene Ontology BP GO:0032075 1.70979505111971e-05 1.91518449033703e-05 2215 3087.72727272727 3165 1.55437121767464e-06 1417 1.23263375514291 1.27269667320866 1 6.16296409935478 2211 3726 3540 2676 4131 2155 1417 3165 4290 3934 2720 3462 M15169 GO_BLASTOCYST_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_GROWTH.html An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. 15/17 Gene Ontology BP GO:0001832 1.01609184673627e-05 1.16536242614342e-05 3170 3134.45454545455 3166 9.23724126988827e-07 1303 1.13222783620828 1.31472374563583 1 5.91537083833865 3166 3514 3609 3175 4032 2723 1303 2897 2927 3127 4006 3463 M15455 GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. 58/69 Gene Ontology BP GO:0034637 1.04198257852537e-07 2.64071075047851e-07 3360 3120.81818181818 3166 9.47256934433299e-09 1768 1.76731206111506 2.08866516294776 1 12.4339094852225 3360 3655 2888 3635 1768 3558 3166 3003 2785 3436 3075 3464 M10139 GO_RESPONSE_TO_UV_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_C.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. 12/13 Gene Ontology BP GO:0010225 8.07172577110324e-07 1.172580081578e-06 860 2438.90909090909 3168 7.33793521144883e-08 281 0.82002480542945 0.839822870874784 1 5.13569093764575 860 3549 3771 4179 3168 849 281 574 4157 4079 1361 3465 M14921 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT.html Any process that activates or increases the frequency, rate or extent of protein import. 148/215 Gene Ontology BP GO:1904591 9.55611371562999e-07 1.35438919033891e-06 2990 3036.45454545455 3168 8.68737987864564e-08 1819 1.8978109477234 2.05054822506421 1 11.9061322210099 2989 3330 2680 1819 3249 3355 2439 4477 2149 3168 3746 3466 M15261 GO_REGULATION_OF_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. 267/410 Gene Ontology BP GO:0050727 6.94836187198873e-08 2.21140408962815e-07 3170 2626.81818181818 3169 6.31669281040188e-09 300 2.40566741437479 -2.34801139753934 -1 17.1659541868151 3169 2145 300 2703 1367 3744 4017 4411 3170 425 3444 3467 M10446 GO_CELLULAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. 1272/1714 Gene Ontology BP GO:0044248 3.19878570282017e-08 1.97691467186943e-07 2630 3231.45454545455 3170 3.19878574886521e-09 593 1.64733991352726 -1.52285881766114 -1 11.8057045545577 2630 4598 4240 4583 593 2346 2967 3519 2329 4571 3170 3468 M14193 GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSPORT.html Any process that modulates the frequency, rate or extent of cytoplasmic transport. 585/775 Gene Ontology BP GO:1903649 4.43942386436723e-08 1.97691467186943e-07 3170 2860.18181818182 3170 4.43942395305541e-09 987 1.81783291165277 1.99818350720177 1 13.0392522338221 3170 2117 4479 1449 987 3144 3268 3922 1931 3176 3819 3469 M11908 GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSAMINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines). 20/31 Gene Ontology BP GO:1901071 5.65504692036663e-06 6.68010493030361e-06 2960 3310.27272727273 3171 5.14096496052782e-07 2365 1.22012470355186 -0.862622829403675 -1 6.7016121104841 2959 3171 3319 3928 3912 2365 2501 3042 4180 3051 3985 3470 M11243 GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VACUOLAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of vacuolar transport. 21/23 Gene Ontology BP GO:1903337 1.74575078497011e-08 1.97691467186943e-07 3865 2855.72727272727 3172 1.58704618074823e-09 69 1.17858079563829 -1.03356752440153 -1 8.41414755008626 3865 805 3329 2149 69 3256 2973 4594 3172 2840 4361 3471 M14232 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION.html Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. 939/1312 Gene Ontology BP GO:1902533 3.89065372464608e-08 1.97691467186943e-07 3175 2413.90909090909 3172 3.89065379276343e-09 170 2.12637672206344 2.35875600519886 1 15.2716225098334 3172 1186 4481 725 810 3206 3420 3336 2188 170 3859 3472 M13770 GO_OXIDATION_REDUCTION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATION_REDUCTION_PROCESS.html A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. 756/1065 Gene Ontology BP GO:0055114 2.44430243944e-08 1.97691467186943e-07 2130 3001.45454545455 3174 2.44430246632576e-09 317 1.68261492038817 -1.57888685144384 -1 12.0609256095436 2130 3586 4448 4098 317 2358 2616 3174 2587 4277 3425 3473 M14240 GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. 91/152 Gene Ontology BP GO:0043255 3.68533316884893e-06 4.47140944841044e-06 3175 2990.90909090909 3174 3.35030849304961e-07 1990 1.99013061934386 2.59331475150121 1 11.3767398786227 3174 3357 2690 3763 3808 2674 1990 2189 3258 3379 2618 3474 M12568 GO_NOSE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NOSE_DEVELOPMENT.html The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). 18/29 Gene Ontology BP GO:0043584 9.35721738319602e-06 1.07770129910919e-05 3220 3088.27272727273 3176 8.50659743845859e-07 1523 1.85281464065051 1.6585726634065 1 9.81999742327119 3216 3176 2695 3403 4014 3071 1523 4061 3561 2320 2931 3475 M13109 GO_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ADAPTATION.html A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 33/50 Gene Ontology BP GO:0043500 1.28397307919774e-06 1.74154777010421e-06 2965 3021.36363636364 3176 1.16724893505093e-07 2013 2.43073368744608 -1.53063916947668 -1 14.9947965382517 2961 2747 2013 3176 3395 2690 3564 3354 2279 3271 3785 3476 M10697 GO_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_DNA_REPLICATION.html The DNA-dependent DNA replication that takes place as part of the cell cycle. 12/13 Gene Ontology BP GO:0044786 6.95695557085351e-05 7.42958785200399e-05 275 2404.81818181818 3179 6.32470507008845e-06 28 1.12170053718278 1.12170053718278 1 4.8854072627879 272 3251 3386 3179 4452 541 28 1658 4142 3492 2052 3477 M15133 GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that activates or increases the frequency, rate or extent of natural killer cell activation. 16/23 Gene Ontology BP GO:0032816 8.24591317474056e-07 1.1937845053537e-06 2760 3213.54545454545 3179 7.4962875140253e-08 1926 1.65103285685334 -1.18960523965314 -1 10.4409118976707 2760 3507 2550 3895 3179 2591 2580 4542 4144 1926 3675 3478 M16243 GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that activates or increases the rate of ATP hydrolysis by an ATPase. 63/76 Gene Ontology BP GO:0032781 1.14974587130978e-07 2.78924272117018e-07 3610 3202.90909090909 3180 1.04522357399714e-08 1854 1.71005795855016 1.91807394931501 1 11.9835744540586 3606 2679 2852 3180 1854 4323 4442 3566 4061 2068 2601 3479 M16969 GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BETA_OXIDATION.html Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation. 19/23 Gene Ontology BP GO:0031998 8.37154078066032e-05 8.90145778162991e-05 3400 3370 3181 7.61078123212432e-06 2050 2.05056175502319 2.17938894342535 1 8.85086957141783 3398 3181 2851 2401 4362 3791 3129 4423 2050 2921 4563 3480 M12103 GO_CHOLESTEROL_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_EFFLUX.html The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. 18/31 Gene Ontology BP GO:0033344 1.88748671652048e-08 1.97691467186943e-07 3600 2955.27272727273 3182 1.71589702974012e-09 100 2.38485700909442 2.81432802483519 1 17.1417741389807 3599 3182 1981 3124 100 4616 4045 3765 3749 1883 2464 3481 M12475 GO_LONG_TERM_SYNAPTIC_DEPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_TERM_SYNAPTIC_DEPRESSION.html A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. 17/24 Gene Ontology BP GO:0060292 1.23262121086046e-06 1.68391446526737e-06 3435 2887.45454545455 3182 1.12056536497903e-07 1460 1.89351958867091 -1.70660454379141 -1 11.6856826321186 3431 2480 2384 3352 3370 3182 4136 1460 2373 3386 2208 3482 M13030 GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOLAMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. 8/21 Gene Ontology BP GO:0042423 7.54728982020745e-07 1.10702955970865e-06 2015 3056.63636363636 3182 7.54729238347994e-08 972 3.01144071959411 3.53556583125578 1 19.2436327729241 2015 4079 4402 4385 3182 2182 972 3704 3766 2810 2126 3483 M16878 GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATECHOL_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. 8/21 Gene Ontology BP GO:0009713 7.54728982020745e-07 1.10702955970865e-06 2020 3080.27272727273 3183 7.54729238347994e-08 973 3.01144071959411 3.53556583125578 1 19.2436327729241 2016 4080 4650 4386 3183 2183 973 3702 3767 2816 2127 3484 M10802 GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCH_ELONGATION_OF_AN_EPITHELIUM.html The growth process in which a branch increases in length from its base to its tip. 19/23 Gene Ontology BP GO:0060602 1.09531582337787e-05 1.25159737872722e-05 4630 3019.09090909091 3184 9.95746615158048e-07 1245 2.57140251116372 -2.41710720190998 -1 13.4921171159798 4627 3184 1941 1245 4047 4422 3966 2102 1515 2503 3658 3485 M14646 GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that stops, prevents, or reduces the rate of leukocyte degranulation. 7/18 Gene Ontology BP GO:0043301 4.35648357291929e-05 4.70427432462137e-05 3890 3074.81818181818 3184 4.35656898054684e-06 1234 1.87249517065742 -2.8766434071218 -1 8.63217038428303 3888 2081 4507 3105 4303 3510 3184 2125 1234 2514 3372 3486 M14845 GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. 57/107 Gene Ontology BP GO:0042108 5.94807340579977e-06 7.00490649384619e-06 3160 3075 3184 5.40735407953333e-07 1682 2.14376396323641 -1.97744164082657 -1 11.8126699476851 3157 3368 1893 2981 3924 3761 4616 1682 3518 1741 3184 3487 M12195 GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTONEMAL_COMPLEX_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. 20/31 Gene Ontology BP GO:0070193 0.000166958093199849 0.000174417603874921 890 2722.09090909091 3185 1.5179160454815e-05 157 1.552577705818 1.55552988640336 1 6.18445876478289 886 4239 3185 3749 4442 674 157 2817 4408 3916 1470 3488 M14235 GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION.html Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. 17/20 Gene Ontology BP GO:0010745 4.72891707046874e-07 7.56399145028913e-07 3910 3236.09090909091 3185 4.29901644268496e-08 1701 2.06231132026579 -1.98095235074195 -1 13.5110353135509 3907 2883 2239 3155 2875 3467 3693 4071 4421 1701 3185 3489 M10981 GO_SUCKLING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUCKLING_BEHAVIOR.html Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. 12/21 Gene Ontology BP GO:0001967 8.35280909167892e-07 1.20738181744585e-06 4055 3024.09090909091 3186 7.5934656936526e-08 1062 1.5725575641019 -0.984442760533365 -1 9.93092116982321 4053 2533 2979 3898 3186 3678 2184 2302 1062 3843 3547 3490 M13150 GO_TETRAHYDROFOLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. 19/20 Gene Ontology BP GO:0046653 4.71920965983675e-06 5.61598019110496e-06 1640 3143.27272727273 3186 4.29019980274692e-07 1638 1.42214616968983 1.66846526864945 1 7.94561477888959 1638 2476 3175 3674 3881 3186 4551 1969 3826 3281 2919 3491 M12604 GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER.html The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. 18/41 Gene Ontology BP GO:0060795 1.33872648803058e-06 1.80396592783269e-06 4070 3097.45454545455 3188 1.21702482060223e-07 879 2.53495478587708 -1.98260908388166 -1 15.6007301141247 4070 3188 2409 3154 3420 4261 4296 879 1607 3159 3629 3492 M10954 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus. 61/71 Gene Ontology BP GO:2001021 1.30475868662974e-07 2.99508740448357e-07 4420 3179.81818181818 3189 1.18614433091941e-08 1827 1.61642903301665 1.87323259554804 1 11.2673131053838 2540 4416 3495 4418 1968 2905 1827 2396 3189 4071 3753 3493 M11177 GO_REGULATION_OF_BODY_FLUID_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BODY_FLUID_LEVELS.html Any process that modulates the levels of body fluids. 509/777 Gene Ontology BP GO:0050878 1.39921329612833e-10 3.0442537290238e-09 3215 2370.81818181818 3190 1.39921329621643e-11 100 2.51067275063084 2.7527869593429 1 22.963237650894 3212 1263 4283 406 340 3426 3748 3190 2485 100 3626 3494 M11408 GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. 14/19 Gene Ontology BP GO:0035886 1.67434126523847e-05 1.8772794956999e-05 3790 3359.54545454545 3193 1.52214000744218e-06 1897 2.10026337820854 2.0361963622145 1 10.6002541575803 3789 3528 2487 3156 4127 3193 2927 1897 4284 2950 4617 3495 M12704 GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 35/39 Gene Ontology BP GO:0042558 1.93593557414103e-07 3.89615407719645e-07 2945 3218.90909090909 3194 1.75994158590701e-08 1842 1.92975192017198 1.97194946911968 1 13.2353577214898 2944 1842 2753 4490 2274 3911 4481 3538 1978 3194 4003 3496 M14395 GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EPIDERMAL_GROWTH_FACTOR_ACTIVATED_RECEPTOR_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. 9/11 Gene Ontology BP GO:0045741 2.30012848333523e-07 4.36090785295291e-07 4415 3184.36363636364 3195 2.30012872141186e-08 1014 2.00120721787641 -1.44614285321428 -1 13.6239267575672 4414 2565 4490 1975 2496 4137 3685 3195 1014 2433 4624 3497 M11455 GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAPYRROLE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. 26/28 Gene Ontology BP GO:0033014 4.73132178600204e-07 7.56523720627749e-07 1500 3342.72727272727 3197 4.30120254865527e-08 1499 0.794301469867786 -0.830638676524226 -1 5.13419079392887 1499 4485 3975 4448 2876 2355 2129 3034 4486 4286 3197 3498 M15985 GO_RESPONSE_TO_FOLIC_ACID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FOLIC_ACID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. 18/23 Gene Ontology BP GO:0051593 8.55712611562499e-07 1.23270302835923e-06 4500 3042.36363636364 3197 7.77920858546267e-08 587 2.72695126125452 -3.04782137886207 -1 17.2775746783406 4499 2474 1716 2520 3197 4557 3539 3256 587 2770 4351 3499 M10423 GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN.html The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. 10/27 Gene Ontology BP GO:0001991 5.46045521591264e-06 6.46665770415921e-06 3575 3060.18181818182 3198 4.96406251722421e-07 1047 1.93078635068519 -1.02053846138691 -1 10.7002281046852 3573 3829 2526 3645 3903 3176 3957 1047 2896 3198 1912 3500 M16695 GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERAD pathway. 17/17 Gene Ontology BP GO:1904294 4.04642517894444e-08 1.97691467186943e-07 4595 2817.36363636364 3199 3.67856841215428e-09 140 1.55469323231207 2.06486366126183 1 11.1353890585489 4594 3199 3333 2210 750 3388 2900 3112 140 3703 3662 3501 M11648 GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. 10/13 Gene Ontology BP GO:0032352 2.47493424158532e-07 4.57968762198223e-07 4540 3073.09090909091 3200 2.24994047273461e-08 1465 2.6797543995271 -2.61300570212196 -1 18.220242404913 4537 3559 2073 1769 2470 4384 4288 1465 1935 3200 4124 3502 M15508 GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. 29/31 Gene Ontology BP GO:0006760 8.62331088026883e-07 1.24108461261648e-06 2605 3212.54545454545 3200 7.83937660030768e-08 1875 2.13925552905573 2.0913420602792 1 13.5228496425102 2602 2389 2521 4491 3200 3311 4621 3316 1875 3149 3863 3503 M11946 GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_CELL_CYCLE_DNA_REPLICATION.html Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. 10/11 Gene Ontology BP GO:0033262 0.00654239920694191 0.00664667762224906 1025 2960.27272727273 3201 0.000596539681757397 538 1.56125265980428 1.56125265980428 1 3.55571124536238 1023 4310 3411 4186 4638 1909 538 2178 4369 3201 2800 3504 M13355 GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 47/57 Gene Ontology BP GO:0090199 8.7457725371052e-07 1.25754263334829e-06 3930 3295.90909090909 3204 7.95070546714439e-08 1227 2.07367935560133 2.40908860892065 1 13.0920527038473 3929 4432 2818 2629 3204 3980 3037 3008 1227 4239 3752 3505 M16728 GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. 326/481 Gene Ontology BP GO:0002237 8.30775547214678e-08 2.38912152113096e-07 3595 2664.18181818182 3204 7.55250525988059e-09 364 2.07999109721097 -2.07230949202698 -1 14.7513792837207 3591 2135 683 1883 1541 4141 4550 3204 3447 364 3767 3506 M11470 GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 23/27 Gene Ontology BP GO:0009067 4.39929099839188e-07 7.12988541118684e-07 3480 3097.09090909091 3206 3.99935625282595e-08 661 1.55201929685374 1.64175678339659 1 10.1829157931317 3480 2414 3206 3075 2834 4395 3766 3297 661 3098 3842 3507 M12537 GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VESICLE_FUSION_TO_PLASMA_MEMBRANE.html Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. 10/13 Gene Ontology BP GO:0099500 0.00239665691773688 0.00244446397155408 2145 3000 3206 0.000218115618143844 1161 1.23024579885548 -1.1294086734296 -1 3.35466312028907 2145 3832 3404 3493 4549 2133 1161 2415 4262 3206 2400 3508 M11433 GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. 71/79 Gene Ontology BP GO:0032922 4.80654547558153e-06 5.71552673086656e-06 2855 2989.54545454545 3208 4.36959634265679e-07 1393 1.57191162266247 1.83938269648491 1 8.78132834185012 2852 3363 3572 2615 3885 2738 1881 3208 1393 4088 3290 3509 M15459 GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. 12/18 Gene Ontology BP GO:0014741 9.2442192319623e-06 1.0654781294605e-05 1400 2800.36363636364 3209 8.40387097785494e-07 1397 1.37365664102973 1.51469580068551 1 7.25853516678088 1397 3250 3277 3209 4011 1910 1915 1978 4236 3501 2120 3510 M15910 GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPTIC_VESICLE_FUSION_TO_PRESYNAPTIC_ACTIVE_ZONE_MEMBRANE.html Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. 10/13 Gene Ontology BP GO:0031629 0.00239665691773688 0.00244446397155408 2150 2997.09090909091 3210 0.000218115618143844 1162 1.23024579885548 -1.1294086734296 -1 3.35466312028907 2146 3833 3405 3494 4550 2134 1162 2370 4263 3210 2401 3511 M11709 GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glutathione derivative. 18/28 Gene Ontology BP GO:1901687 3.80694578020968e-07 6.394844301558e-07 3435 3400.18181818182 3211 3.46086039906829e-08 2735 1.4456392164433 -1.32754494955143 -1 9.55091848928684 3435 3773 3211 3171 2735 3139 2928 3896 4544 3156 3414 3512 M16344 GO_FOLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 20/20 Gene Ontology BP GO:0046655 8.32567528760417e-06 9.64385539288579e-06 3540 3106.54545454545 3211 7.56882435948985e-07 405 2.27778966271107 2.14942297439488 1 12.2169297992734 3539 2444 2164 3052 3990 4636 3211 3717 405 2668 4346 3513 M12449 GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTATHIONE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutathione derivative. 18/28 Gene Ontology BP GO:1901685 3.80694578020968e-07 6.394844301558e-07 3440 3399.72727272727 3212 3.46086039906829e-08 2736 1.4456392164433 -1.32754494955143 -1 9.55091848928684 3436 3774 3212 3172 2736 3140 2929 3880 4545 3158 3415 3514 M16565 GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION.html Any process that activates or increases the frequency, rate or extent of establishment of protein localization. 600/851 Gene Ontology BP GO:1904951 5.71885673419404e-08 2.06919443112013e-07 3460 2994.54545454545 3214 5.71885688136798e-09 1264 1.98062531842615 2.05110653579498 1 14.1747325959614 3458 2116 4636 1797 1264 3441 3214 4499 2109 2311 4095 3515 M16760 GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. 232/280 Gene Ontology BP GO:0009895 8.05091189660433e-08 2.35603100974214e-07 3740 2974.18181818182 3217 7.31901108293448e-09 1505 1.69152973172999 -1.56261144655661 -1 11.9863314463378 3738 2610 3431 1812 1505 3538 4628 3217 2229 3575 2433 3516 M13428 GO_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOUBLE_STRAND_BREAK_REPAIR.html The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. 158/195 Gene Ontology BP GO:0006302 3.3453839598974e-06 4.08880261765238e-06 1075 2772.81818181818 3218 3.04126276999667e-07 874 1.33903794538054 1.45936504948366 1 7.67385663763157 1073 3613 4089 3571 3780 874 1028 2579 3218 4027 2649 3517 M14291 GO_MACROPHAGE_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROPHAGE_CHEMOTAXIS.html The movement of a macrophage in response to an external stimulus. 11/17 Gene Ontology BP GO:0048246 3.92031298626359e-07 6.5451081180784e-07 3300 2950 3218 3.56392153168003e-08 1248 3.81920228874554 -5.38178090304209 -1 25.376476995948 3297 3821 1491 3349 2752 3218 3883 1248 4175 2902 2314 3518 M16935 GO_ACTIVATION_OF_MAPKK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACTIVATION_OF_MAPKK_ACTIVITY.html The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK). 63/76 Gene Ontology BP GO:0000186 1.79081539705954e-07 3.68865163458081e-07 3770 3122.54545454545 3219 1.62801412984835e-08 1271 2.08654402830466 2.17217171513029 1 14.3734414833684 3769 3046 2388 2400 2215 4059 3630 3819 1271 3219 4532 3519 M16645 GO_ORGANELLE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_DISASSEMBLY.html The disaggregation of an organelle into its constituent components. 197/263 Gene Ontology BP GO:1903008 9.11547963060982e-08 2.48910368082321e-07 3280 3265.27272727273 3220 8.28680000754603e-09 1637 1.96648166748272 -1.5584224770293 -1 13.9024071185277 3279 4098 2920 4488 1637 1884 3220 4523 3080 4026 2763 3520 M10698 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 12/14 Gene Ontology BP GO:0034244 0.000779030966314487 0.000800890650963612 2180 3311.27272727273 3221 7.08460874451414e-05 2180 0.749578012828102 -0.730644284744844 -1 2.39181307733478 2180 3822 3761 3221 4518 2289 2644 2488 4389 4292 2820 3521 M11741 GO_HISTONE_H2A_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_MONOUBIQUITINATION.html The modification of histone H2A by addition of a single ubiquitin group. 15/15 Gene Ontology BP GO:0035518 2.50624812155358e-05 2.76013550522812e-05 3225 3165 3221 2.27843333934552e-06 1739 0.660232184225689 0.692347560460866 1 3.13543707507932 2731 3221 3884 3223 4202 2682 2001 1739 4260 4368 2504 3522 M15862 GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 13/16 Gene Ontology BP GO:0032785 0.000561895122167116 0.000578300819164696 1890 3142.81818181818 3222 5.10944259436445e-05 1887 0.710171933555039 -0.688313583873237 -1 2.36851685298329 1887 3240 3796 3222 4510 2023 2203 2403 4367 4320 2600 3523 M13578 GO_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_GENOME_REPLICATION.html Any process involved directly in viral genome replication, including viral nucleotide metabolism. 21/31 Gene Ontology BP GO:0019079 9.06050962987666e-07 1.29519358856578e-06 2510 2980 3223 8.23683032851935e-08 1411 0.973588398198584 1.00188773627985 1 6.07323269081287 2508 4009 3886 3552 3223 2407 1730 2441 3345 4268 1411 3524 M14393 GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 53/56 Gene Ontology BP GO:0032206 1.04409318157806e-05 1.1945329662854e-05 1350 2894.45454545455 3225 9.49180124318137e-07 603 1.3460232877376 1.27652596123818 1 7.03811236744891 1347 4165 3968 4054 4042 1349 603 2020 3225 4345 2721 3525 M13588 GO_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that modulates the frequency, rate or extent of muscle hypertrophy. 45/55 Gene Ontology BP GO:0014743 1.20172827127418e-06 1.64411692038776e-06 3175 3327.72727272727 3226 1.09248084336989e-07 2702 1.68857771160034 1.44403629466007 1 10.4275911988639 3171 3930 3156 3226 3365 2884 2702 3640 3519 3113 3899 3526 M16827 GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GONADOTROPIN_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. 14/22 Gene Ontology BP GO:0071371 1.33679745487737e-06 1.80293291523026e-06 3415 2473.63636363636 3226 1.2152711519666e-07 356 3.21996470599679 -4.31067732337295 -1 19.8478746329595 3412 3226 1973 1758 3417 3989 3767 356 523 3372 1417 3527 M10549 GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_SISTER_CHROMATID_SEPARATION.html Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. 14/14 Gene Ontology BP GO:1901970 5.98637141242076e-06 7.04287893350033e-06 2060 2765.81818181818 3227 5.44217063805987e-07 456 1.59662948159174 1.73172559040566 1 8.76491289543128 2057 3524 3227 3465 3926 1836 456 3088 3267 3353 2225 3528 M15620 GO_PROTEIN_CHROMOPHORE_LINKAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CHROMOPHORE_LINKAGE.html The covalent or noncovalent attachment of a chromophore to a protein. 6/12 Gene Ontology BP GO:0018298 5.29327839173734e-06 6.27346519530154e-06 2760 3152.18181818182 3227 5.29329100023788e-07 1007 2.06265859193764 -2.12009820590546 -1 11.4680984959648 2759 3845 4563 3877 3917 3227 2912 1007 4259 2169 2139 3529 M15986 GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT.html The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. 10/14 Gene Ontology BP GO:0003417 2.52280613851584e-06 3.1640476987909e-06 3125 3034.27272727273 3227 2.29346275590739e-07 1622 1.96176293075848 2.5261158170891 1 11.5309675052884 3125 3266 2482 2933 3680 3390 3496 1622 4071 2085 3227 3530 M10647 GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOTIC_METAPHASE_ANAPHASE_TRANSITION.html Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition. 14/14 Gene Ontology BP GO:0045842 5.98637141242076e-06 7.04287893350033e-06 2060 2771.45454545455 3228 5.44217063805987e-07 457 1.59662948159174 1.73172559040566 1 8.76491289543128 2058 3525 3228 3466 3927 1837 457 3140 3268 3354 2226 3531 M15428 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter. 19/20 Gene Ontology BP GO:0045943 1.43132364087895e-06 1.91267917892296e-06 3750 2866 3228 1.30120415645575e-07 688 1.84974813594617 1.10549075367084 1 11.3024968370681 3747 2465 2841 2187 3453 3236 3228 3392 688 3283 3006 3532 M15715 GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_METAPHASE_ANAPHASE_TRANSITION_OF_CELL_CYCLE.html Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle. 14/14 Gene Ontology BP GO:1902101 5.98637141242076e-06 7.04287893350033e-06 2060 2780.18181818182 3229 5.44217063805987e-07 458 1.59662948159174 1.73172559040566 1 8.76491289543128 2059 3526 3229 3467 3928 1838 458 3213 3269 3368 2227 3533 M16541 GO_DNA_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION.html The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. 217/248 Gene Ontology BP GO:0006260 7.22640672248647e-06 8.42507403651454e-06 105 2446.27272727273 3229 6.56948223581178e-07 101 1.24814215306394 1.28651999689767 1 6.72232857848978 101 3318 4099 3229 3964 619 373 1531 3787 3705 2183 3534 M11703 GO_ENDOCARDIUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCARDIUM_DEVELOPMENT.html The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. 13/14 Gene Ontology BP GO:0003157 0.000173287808121519 0.000180908272647393 4160 3068.72727272727 3230 1.57546780927102e-05 533 2.18610357111505 2.1126948385058 1 8.71672478619512 4157 2919 2340 1640 4444 4565 4098 3964 533 3230 1866 3535 M14797 GO_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_REACTION.html The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg. 12/28 Gene Ontology BP GO:0007340 1.66881671374178e-06 2.18547823502406e-06 2025 3073.63636363636 3232 1.5171072542083e-07 1444 2.25735521613393 -1.71685055606816 -1 13.6769490436767 4367 3232 2023 2755 3522 4405 3827 3255 1444 2024 2956 3536 M13184 GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS.html Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 13/16 Gene Ontology BP GO:0010870 2.87965889579559e-05 3.15271831579692e-05 3235 2956.81818181818 3234 2.61790599034029e-06 191 2.40608528747849 -1.59652432415227 -1 11.5755700049971 3917 3234 2523 2023 4228 3810 2815 2597 191 3234 3953 3537 M16367 GO_PHOSPHOLIPID_EFFLUX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHOLIPID_EFFLUX.html The directed movement of a phospholipid out of a cell or organelle. 9/18 Gene Ontology BP GO:0033700 2.08730540483888e-07 4.0876397511428e-07 4025 3407.72727272727 3234 2.08730560089687e-08 1825 2.6693259147297 2.98594366532833 1 18.2911033458033 4023 2950 4618 3083 2408 4460 3686 3234 4301 1825 2897 3538 M16829 GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). 21/71 Gene Ontology BP GO:0030520 9.27590165410403e-07 1.32192252363081e-06 4280 2977 3234 8.43264142283846e-08 415 2.00844911199154 -2.45257553697548 -1 12.6296674755531 4276 3472 3024 2380 3234 4198 4394 1678 415 3760 1916 3539 M13431 GO_METHIONINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 13/16 Gene Ontology BP GO:0009086 1.2859701815408e-07 2.96512351571324e-07 2550 3074 3235 1.16906386973624e-08 1955 1.08176259892613 1.25836651602681 1 7.50811121597952 2550 2530 3518 2599 1955 4071 4275 2418 3325 3235 3338 3540 M14223 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. 13/28 Gene Ontology BP GO:0032695 1.27105319576723e-06 1.72778572010077e-06 2465 3005.81818181818 3236 1.15550357283696e-07 1428 1.8023188968477 1.88216002330936 1 11.0956719144345 2463 4046 2636 3444 3389 1808 1428 4581 3685 3236 2348 3541 M15415 GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. 13/13 Gene Ontology BP GO:1904293 1.14063045006806e-06 1.57301525908911e-06 2065 2713.09090909091 3236 1.03693731040847e-07 927 0.985595053922996 -1.23007036728442 -1 6.05975165755832 2064 3236 3471 3367 3340 2031 927 2393 3757 4135 1123 3542 M11214 GO_RESPONSE_TO_POTASSIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_POTASSIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. 10/20 Gene Ontology BP GO:0035864 1.97650871485985e-05 2.20174648078595e-05 4020 3113.09090909091 3237 1.79684224754134e-06 1907 3.65586072570734 3.6318888739467 1 18.2621069537574 4016 4071 2092 3359 4156 3237 2583 3678 2468 2677 1907 3543 M14250 GO_DNA_REPLICATION_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPLICATION_CHECKPOINT.html A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. 13/15 Gene Ontology BP GO:0000076 7.83885530969757e-05 8.34267926715983e-05 795 2560.18181818182 3237 7.12648602831173e-06 575 1.79039113486724 1.79039113486724 1 7.76794529425691 795 3245 3309 3682 4357 1321 575 1637 3665 3237 2339 3544 M10915 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. 324/441 Gene Ontology BP GO:0090316 1.57471531510164e-07 3.36570985813869e-07 2630 3176.72727272727 3238 1.43155947983325e-08 2125 1.6876057725828 1.8220742722687 1 11.6761493949189 2629 4328 3732 3839 2125 2660 2470 3265 2486 4172 3238 3545 M10140 GO_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 106/151 Gene Ontology BP GO:0016052 2.50281564765519e-08 1.97691467186943e-07 3240 3040.54545454545 3239 2.27528697829847e-09 263 1.47908049790433 -1.39417962102027 -1 10.5883172486976 3425 2646 3596 4394 263 2967 3595 2206 3239 3876 3239 3546 M14423 GO_I_KAPPAB_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_PHOSPHORYLATION.html The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 32/54 Gene Ontology BP GO:0007252 5.56167040432293e-06 6.57815261599252e-06 1940 2966.27272727273 3239 5.05607678586678e-07 975 1.82673504268064 1.73572694219629 1 10.1028547461738 1939 4188 2934 3239 3907 1407 975 3884 3643 3431 3082 3547 M16567 GO_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. 52/56 Gene Ontology BP GO:0051972 7.53145809470792e-07 1.10636652808401e-06 3285 3312.45454545455 3239 6.84678243001911e-08 2165 1.96941113903898 2.41711458836255 1 12.5463000976461 3281 4158 3239 3005 3136 2936 2165 3959 2315 4009 4234 3548 M15481 GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 75/104 Gene Ontology BP GO:0046916 2.8849177277237e-08 1.97691467186943e-07 2805 3068.63636363636 3240 2.62265251414034e-09 382 1.87303917389631 -2.04851136602957 -1 13.438679526556 2802 3643 3162 3664 382 2893 3066 3668 3802 3433 3240 3549 M11201 GO_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEX_DETERMINATION.html Any process that establishes and transmits the specification of sexual status of an individual organism. 12/29 Gene Ontology BP GO:0007530 4.19637499770515e-06 5.04019950034126e-06 2555 3376.54545454545 3241 3.81489363824854e-07 2319 2.29236159429039 -2.19312936175116 -1 12.992987289401 4398 3241 2319 2554 3849 4163 3221 4225 2670 2551 3951 3550 M13390 GO_REGULATION_OF_CYTOKINESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOKINESIS.html Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. 63/100 Gene Ontology BP GO:0032465 1.33353813880515e-07 3.03124228620437e-07 4525 3173 3241 1.21230747239824e-08 1714 1.51459410750876 -1.26131185328833 -1 10.5418298214933 4523 1714 3241 2814 1988 3849 3607 4115 2353 2827 3872 3551 M10362 GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. 180/198 Gene Ontology BP GO:0032434 1.12775429096748e-07 2.74735116014223e-07 2715 3162.81818181818 3242 1.02523122616175e-08 1713 1.49980664976988 1.54478250104166 1 10.5069287699153 2711 3871 3951 3242 1844 2431 2222 4537 1713 4363 3906 3552 M13644 GO_OUTER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_OUTER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 34/61 Gene Ontology BP GO:0036158 3.27215149625909e-07 5.6683994460512e-07 4610 3383.72727272727 3242 2.97468362085444e-08 2059 2.21844590984204 -2.32560213095347 -1 14.8424714006617 4609 3957 2059 3979 2645 4225 3696 2881 3242 2833 3095 3553 M13932 GO_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. 398/504 Gene Ontology BP GO:0051052 4.141010965319e-07 6.81816136646473e-07 1590 3048.36363636364 3242 3.76455613161134e-08 1472 1.53266283687626 1.6232357520426 1 10.0866208335442 1588 4095 4008 3837 2789 2087 1472 3242 2920 4222 3272 3554 M11004 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 14/18 Gene Ontology BP GO:0060261 0.00874082065959792 0.00886658786333314 1900 3294.09090909091 3244 0.000797794838458064 1801 0.816574253573353 0.816574253573353 1 1.69548834674997 1896 4578 3905 3244 4636 2396 1801 2169 4499 4178 2933 3555 M14055 GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. 27/31 Gene Ontology BP GO:2001267 2.68553395839877e-08 1.97691467186943e-07 3335 2859.45454545455 3245 2.44139453743728e-09 314 1.33048357858332 -1.14771455727792 -1 9.51319166002494 3334 2397 3339 3996 314 3036 3370 2151 3467 3245 2805 3556 M15752 GO_HETEROCHROMATIN_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HETEROCHROMATIN_ORGANIZATION.html Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. 11/13 Gene Ontology BP GO:0070828 3.82017352767476e-06 4.61815209775803e-06 3245 3141.72727272727 3245 3.47289105563873e-07 2051 1.35325845262782 -1.392262767214 -1 7.67933507398923 3245 3261 3140 2900 3821 2483 2115 4083 3715 3745 2051 3557 M10440 GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. 25/29 Gene Ontology BP GO:0045648 3.75232732311999e-07 6.3288129935463e-07 2280 2944.45454545455 3246 3.41120723919849e-08 923 1.47928910389769 1.28531809371636 1 9.7830626194625 2279 3981 3044 3718 2724 3278 1945 923 3666 3585 3246 3558 M10719 GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION_OF_PEPTIDE_ANTIGEN.html Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen. 11/15 Gene Ontology BP GO:0002583 2.45400017674559e-07 4.55090363743482e-07 3265 2902 3247 2.23090950043474e-08 921 2.82544240043173 -2.81434681160839 -1 19.2253056701002 3261 3247 1592 2496 2465 4097 4507 4481 3553 1302 921 3559 M15998 GO_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BINDING.html Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 390/486 Gene Ontology BP GO:0051098 1.62089221046005e-07 3.43529588499272e-07 3110 3188.63636363636 3247 1.47353848171128e-08 2148 1.65089795212015 1.95811686746622 1 11.403881718353 3109 3856 3496 3247 2148 3288 2693 2968 3364 3944 2962 3560 M16882 GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. 18/22 Gene Ontology BP GO:0000737 1.94936927604779e-06 2.50771778862327e-06 3260 2702.45454545455 3249 1.77215545758282e-07 433 1.56657919976019 -2.15134075799561 -1 9.35605078298846 3257 2872 3249 2853 3583 3291 4327 1566 806 3490 433 3561 M10119 GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PHOSPHOPROTEIN_PHOSPHATASE_ACTIVITY.html Any process that stops or reduces the activity of a phosphoprotein phosphatase. 17/18 Gene Ontology BP GO:0032515 9.12232868098608e-05 9.66663524314011e-05 3255 3128.72727272727 3254 8.29336996499446e-06 684 2.27619164867211 -2.42271628222067 -1 9.7492247492555 3254 4258 3081 2954 4555 3633 3636 684 2676 3380 2305 3562 M11260 GO_TELOMERE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. 89/120 Gene Ontology BP GO:0032200 4.75248619138327e-05 5.11882366863574e-05 615 2637.27272727273 3254 4.32053532608437e-06 309 1.15566979756897 1.09424372574874 1 5.23857643235812 613 3638 4009 3254 4302 760 309 1436 4326 4346 2017 3563 M13933 GO_NADH_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_METABOLIC_PROCESS.html The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. 35/54 Gene Ontology BP GO:0006734 5.41236884889961e-07 8.41702949663432e-07 3270 2993.45454545455 3255 4.92033652766685e-08 1600 1.31891036792002 -1.48576547860908 -1 8.53388946083016 3266 3422 3616 3740 2956 2489 2418 1600 3255 3996 2170 3564 M14586 GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUROTRANSMITTER_UPTAKE.html Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. 16/27 Gene Ontology BP GO:0051580 7.44413169264841e-05 7.94074845618823e-05 3475 3331.09090909091 3256 6.76762144671305e-06 1505 1.98027085557526 -2.36238914640362 -1 8.64959809745919 3471 3787 2784 3200 4349 2735 1505 4264 4374 3256 2917 3565 M15314 GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DIVALENT_INORGANIC_ANION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. 10/16 Gene Ontology BP GO:0072505 4.58239824765937e-07 7.38037350168191e-07 3535 3066.45454545455 3256 4.16581745648289e-08 1419 2.92946546668175 -1.89498643167466 -1 19.273410164739 3535 3256 1419 2403 2853 4328 3870 3730 2783 1572 3982 3566 M13819 GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that activates or increases the frequency, rate or extent of chromatin modification. 97/111 Gene Ontology BP GO:1903310 1.11157645135468e-06 1.53933488933135e-06 2665 3232.81818181818 3258 1.01052455726586e-07 2591 1.74317183318592 1.92779323021198 1 10.8221906764846 2665 3631 3423 2678 3327 3056 2591 3258 3079 4279 3574 3567 M14305 GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTEROENDOCRINE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. 15/27 Gene Ontology BP GO:0035883 0.00192752303983591 0.00196985827022985 2955 3054.09090909091 3258 0.000175383082494596 281 2.357594324917 -2.18510064623242 -1 6.77091493359807 2951 4042 2648 2582 4543 3258 3068 3358 281 3474 3390 3568 M14674 GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. 189/234 Gene Ontology BP GO:1901796 1.40470680784114e-06 1.88143372967323e-06 830 2678.18181818182 3258 1.27700700431962e-07 826 1.46546374300058 1.63294442427535 1 8.94222523047536 826 4104 4000 3258 3442 970 965 2133 3386 4351 2025 3569 M12380 GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNATE_IMMUNE_RESPONSE_ACTIVATING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. 105/149 Gene Ontology BP GO:0002220 0.00747587275348654 0.00758840225173928 1730 3341.45454545455 3259 0.000681945292086895 1729 1.34780439048283 -1.16526155058279 -1 2.97042063441887 1729 4375 4129 3259 4587 2653 2575 2122 4079 4512 2736 3570 M11046 GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SUPEROXIDE_ANION_GENERATION.html Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell. 13/17 Gene Ontology BP GO:0032928 0.0046842510423632 0.00476619726658998 4345 3491.09090909091 3260 0.000426750418674109 2216 2.14379065938782 -1.39536997278533 -1 5.25879120309475 4344 3260 2968 2216 4558 4591 3095 3179 3725 2785 3681 3571 M13719 GO_MALE_MEIOSIS_I http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_MEIOSIS_I.html A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. 19/129 Gene Ontology BP GO:0007141 2.46470950221694e-06 3.0978642122678e-06 985 2734.45454545455 3260 2.24064751226435e-07 804 1.35477771394746 1.42462783672802 1 7.9416233494481 981 3768 3260 4177 3672 1271 804 2176 4456 3611 1903 3572 M14662 GO_SUPEROXIDE_ANION_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_ANION_GENERATION.html The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. 10/16 Gene Ontology BP GO:0042554 2.54286012489783e-06 3.18490663826369e-06 4145 2916.72727272727 3260 2.3116936945964e-07 1100 2.34607089205598 -3.02429819589887 -1 13.8048061889065 4144 1100 1618 4099 3686 3260 3049 1894 3630 1571 4033 3573 M15166 GO_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. 316/378 Gene Ontology BP GO:0033044 1.16833354278422e-06 1.60456197596664e-06 795 2705.63636363636 3260 1.06212196658246e-07 792 1.5688182773189 1.6577360105899 1 9.6979179516999 792 4096 4088 3260 3353 1486 1259 1468 3375 4472 2113 3574 M12925 GO_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. 693/922 Gene Ontology BP GO:0043603 1.07954694018471e-07 2.68108916491833e-07 2240 3446.45454545455 3261 1.07954699262868e-08 1885 1.46339857426695 -1.38297613361699 -1 10.2658713933457 2237 4606 4394 4637 1885 3003 3057 2906 3332 4593 3261 3575 M11726 GO_PEPTIDYL_ARGININE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_MODIFICATION.html The modification of peptidyl-arginine. 15/19 Gene Ontology BP GO:0018195 9.76254079593247e-07 1.37693550540994e-06 3150 3169.54545454545 3262 8.87504102552794e-08 719 1.66381207677957 1.17038997509502 1 10.4112939514173 3147 2024 2703 3070 3262 3489 3986 4485 719 3472 4508 3576 M14578 GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. 13/14 Gene Ontology BP GO:1903140 7.44591281416719e-07 1.09758204435186e-06 3660 3166.54545454545 3263 6.76901394021991e-08 2066 2.73320341930645 1.62657723227413 1 17.4661779545453 3657 3540 2066 2551 3124 3378 2774 3263 3706 2797 3976 3577 M15587 GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRANIOFACIAL_SUTURE_MORPHOGENESIS.html The process in which any suture between cranial and/or facial bones is generated and organized. 16/20 Gene Ontology BP GO:0097094 0.000501265218252383 0.00051692975632277 4005 3075 3263 4.55799515353033e-05 1016 3.04566638897382 -3.58524780398817 -1 10.6897840004367 4005 3508 2109 1768 4499 3255 2458 4134 1016 3263 3810 3578 M16363 GO_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of JUN kinase activity. 119/166 Gene Ontology BP GO:0043506 9.8719895790399e-07 1.38958002751674e-06 2945 3475.27272727273 3267 8.97454000806269e-08 2617 1.7888461945866 -1.68509939804245 -1 11.1945290506332 4463 2640 2617 2656 3267 4625 3601 3969 2943 2944 4503 3579 M16555 GO_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_SILENCING.html Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 51/70 Gene Ontology BP GO:0060968 1.51604045403216e-05 1.71050830082727e-05 3100 3227.90909090909 3267 1.37822809209879e-06 1780 1.50636329211569 1.55157367741219 1 7.6364807062054 3100 2707 3510 2029 4101 3992 4051 1780 3102 3868 3267 3580 M15633 GO_FOREBRAIN_NEURON_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_NEURON_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. 6/14 Gene Ontology BP GO:0021877 0.00677410352508068 0.00688057273569099 4570 3198.81818181818 3269 0.000679484237104116 1382 3.60633552227896 3.60633552227896 1 8.30302055990075 2374 4596 4567 3736 4568 2845 1382 3269 2363 3556 1931 3581 M12878 GO_ORGANIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. 835/1183 Gene Ontology BP GO:0006082 3.01253263145532e-08 1.97691467186943e-07 3270 2719.72727272727 3270 3.0125326722944e-09 528 2.03984433904041 -1.90910590937936 -1 14.6455450671651 3270 1206 4392 3588 528 2961 3297 4144 1957 816 3758 3582 M11824 GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of extracellular matrix assembly. 16/16 Gene Ontology BP GO:1901201 1.96914548154083e-07 3.93237507536888e-07 4245 3097.81818181818 3271 1.79013241617491e-08 860 1.39631298341825 -1.50035537172841 -1 9.53940457482393 4245 1995 2948 860 2291 4286 3510 3271 3670 2861 4139 3583 M10471 GO_RESPONSE_TO_ELECTRICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ELECTRICAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. 42/70 Gene Ontology BP GO:0051602 5.47831559810406e-07 8.50821177502611e-07 4435 3265.54545454545 3272 4.98028814753065e-08 1870 2.62980090113633 -2.6678016111174 -1 17.1150162614327 4432 3399 1870 2591 2960 4117 4542 3272 2133 2241 4364 3584 M11983 GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. 32/44 Gene Ontology BP GO:0006778 1.98909015468454e-07 3.96539695361919e-07 1935 2794.72727272727 3272 1.80826394047687e-08 510 1.49471665565441 -0.837163760906791 -1 10.2137958895828 1935 3691 3272 3897 2295 2331 2030 3406 510 4005 3370 3585 M14935 GO_GLIAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLIAL_CELL_FATE_COMMITMENT.html The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. 8/16 Gene Ontology BP GO:0021781 4.50504159952818e-06 5.3886782937287e-06 3945 3207.27272727273 3272 4.50505073248416e-07 2126 2.49229571248779 -1.4264208928077 -1 14.0579716275173 3945 3272 4526 2196 3888 3781 2531 2126 2387 2142 4486 3586 M12544 GO_IN_UTERO_EMBRYONIC_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IN_UTERO_EMBRYONIC_DEVELOPMENT.html The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. 334/428 Gene Ontology BP GO:0001701 8.0148404172778e-08 2.35520479581606e-07 3635 3228.63636363636 3276 7.28621882660656e-09 1495 1.7531616403571 1.73941585391711 1 12.4274696726851 3634 3595 3173 2594 1495 3509 3029 4596 2297 3276 4317 3587 M12049 GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of endothelial cell development. 13/14 Gene Ontology BP GO:1901550 7.44591281416719e-07 1.09758204435186e-06 3660 3166.36363636364 3277 6.76901394021991e-08 2065 2.73320341930645 1.62657723227413 1 17.4661779545453 3656 3539 2065 2550 3123 3377 2773 3277 3705 2790 3975 3588 M14950 GO_T_CELL_LINEAGE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_T_CELL_LINEAGE_COMMITMENT.html The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. 8/16 Gene Ontology BP GO:0002360 1.93822876707905e-06 2.4947658238503e-06 3225 3387.45454545455 3278 1.93823045760996e-07 2577 2.19095532156183 -2.19922969404948 -1 13.1353940767747 3224 3278 4527 2577 3616 3337 3269 3182 4029 2812 3411 3589 M11997 GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. 442/608 Gene Ontology BP GO:0032388 7.47204220298453e-08 2.28432407164829e-07 2940 3069.81818181818 3280 6.79276586978518e-09 1429 1.72522127075769 1.8023113819632 1 12.2523183630863 2937 3303 3556 2664 1429 3280 3239 3789 2112 3827 3632 3590 M15584 GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process. 14/16 Gene Ontology BP GO:0070234 2.35954527729766e-06 2.97936612625943e-06 4195 2979.45454545455 3280 2.14504346178393e-07 1326 2.87057007540834 -2.92813429723209 -1 17.0061195504642 4193 2512 1326 1796 3655 4355 4259 4224 1641 1533 3280 3591 M15792 GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that activates or increases the activity of a monooxygenase. 27/35 Gene Ontology BP GO:0032770 1.00641793810087e-06 1.41135101446153e-06 4575 3267.54545454545 3280 9.14925816818031e-08 1149 2.19686787091442 2.26758579288697 1 13.757702051585 4572 2783 2240 2181 3280 4320 4040 3625 1149 3246 4507 3592 M16594 GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYTOSOLIC_CALCIUM_ION_CONCENTRATION.html Any process that decreases the concentration of calcium ions in the cytosol. 8/20 Gene Ontology BP GO:0051481 3.29243582444465e-05 3.58439492071618e-05 1530 2644.63636363636 3280 3.29248460606331e-06 222 2.79887532480148 2.74134911843484 1 13.3153865392378 1528 3280 4639 3925 4268 1500 222 1387 3973 3338 1031 3593 M11994 GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that modulates the frequency, rate, or extent of an acute inflammatory response. 51/97 Gene Ontology BP GO:0002673 1.7707820987073e-07 3.65872517996673e-07 4550 3233.45454545455 3282 1.60980203748885e-08 1712 2.07593403234391 1.55774521625738 1 14.307704241019 4546 3669 1712 4501 2208 3282 3371 3180 4216 1880 3003 3594 M14006 GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation. 6/15 Gene Ontology BP GO:0033004 0.000181464775006743 0.00018919014073636 1830 2843.63636363636 3283 1.81479594969051e-05 678 0.886460843013686 0.890255320206548 1 3.44878029739412 1826 3283 4464 3697 4456 1576 678 1741 4112 3555 1892 3595 M11831 GO_MRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. 11/13 Gene Ontology BP GO:0016556 1.27520872644191e-06 1.73242224938225e-06 4230 2977.27272727273 3287 1.15928133236811e-07 61 1.52635282071768 1.61425849027344 1 9.37749893492833 4229 2548 3226 2343 3391 4412 4447 1067 61 3739 3287 3596 M13345 GO_REGULATION_OF_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 1517/2098 Gene Ontology BP GO:0080134 6.26196932500271e-08 2.12948256567067e-07 3360 3164.72727272727 3289 6.26196950145789e-09 1358 1.94057647846377 -1.824817663977 -1 13.8597062190081 3359 2973 4421 3629 1358 3289 4057 3756 2912 2264 2794 3597 M13548 GO_BLASTOCYST_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_DEVELOPMENT.html The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. 54/76 Gene Ontology BP GO:0001824 1.02135568944532e-06 1.42885388544471e-06 2755 3089.63636363636 3289 9.2850560328423e-08 1306 1.40450228756885 1.13786600555747 1 8.74667289805685 2755 3661 3587 3121 3289 2545 1306 4184 1326 3708 4504 3598 M13906 GO_TRACHEA_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_DEVELOPMENT.html The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. 22/31 Gene Ontology BP GO:0060438 1.6806013709494e-08 1.97691467186943e-07 3955 2627.90909090909 3292 1.52781943980698e-09 61 2.05133983088002 -1.44308172945107 -1 14.7287170298654 3954 3733 2807 319 61 4247 4273 1765 582 3292 3874 3599 M14479 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION.html Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition. 28/33 Gene Ontology BP GO:1902750 1.43282361555878e-06 1.91413387401521e-06 1325 2480.36363636364 3293 1.30256777157632e-07 433 1.36929295679043 1.65763935759181 1 8.3369125200371 1322 3722 3625 4165 3454 1501 433 766 3293 3807 1196 3600 M16838 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 29/39 Gene Ontology BP GO:0045922 1.16303670019185e-07 2.81414964430197e-07 4325 2987.72727272727 3293 1.05730614697831e-08 446 1.8224281158863 -1.28785934718446 -1 12.7708690269461 4324 1874 2864 1940 1863 4582 3726 4286 446 3667 3293 3601 M11928 GO_HISTONE_H3_K9_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K9_MODIFICATION.html The modification of histone H3 at a lysine in position 9 of the histone. 20/20 Gene Ontology BP GO:0061647 6.05477954937671e-06 7.11796090026524e-06 2960 3157.27272727273 3295 5.50436019385347e-07 1339 1.20806934648715 1.60562195818452 1 6.5983314360361 2902 3751 3526 2958 3932 2960 1339 3580 3295 3915 2572 3602 M16149 GO_REGULATION_OF_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. 731/971 Gene Ontology BP GO:0032386 4.26164104136767e-08 1.97691467186943e-07 3295 2936.72727272727 3295 4.26164112309479e-09 946 1.82465960734456 1.98710696769791 1 13.0886446119269 3295 2110 4597 1441 946 3360 3668 3903 1805 3225 3954 3603 M13441 GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND.html A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. 36/46 Gene Ontology BP GO:0038034 1.04618136175699e-06 1.46007254836691e-06 4535 3137.90909090909 3296 9.51074417504777e-08 581 1.60977762864644 -1.81653420033642 -1 10.0252670376934 4533 581 2905 2171 3296 4274 4486 4447 2065 2452 3307 3604 M14700 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. 36/46 Gene Ontology BP GO:0097192 1.04618136175699e-06 1.46007254836691e-06 4490 3142.63636363636 3297 9.51074417504777e-08 582 1.60977762864644 -1.81653420033642 -1 10.0252670376934 4534 582 2906 2172 3297 4275 4487 4489 2066 2453 3308 3605 M15210 GO_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHAGOCYTOSIS.html Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. 92/117 Gene Ontology BP GO:0050764 1.90284005083052e-08 1.97691467186943e-07 4445 2782.18181818182 3298 1.72985460662609e-09 103 2.31178807407899 -2.46076889953064 -1 16.6131071778411 4443 2232 849 1378 103 4564 4354 4607 3298 498 4278 3606 M16279 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY.html Any process that activates or increases the activity of the enzyme nitric-oxide synthase. 22/27 Gene Ontology BP GO:0051000 3.12320859495231e-06 3.83437720113803e-06 3530 3159.54545454545 3298 2.83928457163075e-07 2200 1.90037839791998 1.66917706772126 1 10.9954636014467 3530 3460 2781 2200 3761 3298 2467 2996 2506 3597 4159 3607 M13916 GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. 19/24 Gene Ontology BP GO:0055098 1.12138497634192e-07 2.74188349706725e-07 3355 3006.81818181818 3301 1.01944093954655e-08 1836 2.00949681706536 2.46850870869368 1 14.1178856709139 3301 2451 2060 2865 1836 3673 3885 3355 4241 2053 3355 3608 M12855 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_SECRETION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. 14/14 Gene Ontology BP GO:0046929 2.96368761123151e-06 3.65299031922124e-06 4575 3364.09090909091 3302 2.69426509428518e-07 1122 1.39692584064082 -1.50514852861803 -1 8.08428789430058 4575 3213 3284 2425 3746 3679 3302 4410 1122 4182 3067 3609 M12118 GO_LEFT_RIGHT_PATTERN_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEFT_RIGHT_PATTERN_FORMATION.html The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. 25/39 Gene Ontology BP GO:0060972 4.48583418646053e-06 5.36708317552091e-06 3620 3347.81818181818 3303 4.07803939379295e-07 2590 1.71598359731769 1.71085925858376 1 9.64712926154402 3620 3721 2869 3160 3864 2760 2590 3852 2851 3303 4236 3610 M11356 GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SMAD_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. 16/23 Gene Ontology BP GO:0060390 0.00133028413071149 0.00136429624425844 1040 2544.63636363636 3304 0.000121008109213923 207 1.38638354412541 1.48272907629025 1 4.17373435832825 1038 3793 3304 3708 4646 823 207 2404 3449 3881 738 3611 M14469 GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING.html Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. 89/134 Gene Ontology BP GO:0051897 2.90489898056164e-08 1.97691467186943e-07 3580 2453.27272727273 3304 2.64081728992561e-09 152 2.27773201263183 2.28335161880694 1 16.3667054133996 3579 152 904 1392 389 3671 3845 4382 3304 1105 4263 3612 M10125 GO_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_ORGANIZATION.html A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. 924/1244 Gene Ontology BP GO:0051276 9.64192183424882e-07 1.36472312783316e-06 470 2627.54545454545 3305 9.64192601775093e-08 466 1.41692020201404 1.44749176118657 1 8.85550355163203 466 4088 4226 3848 3306 841 954 1444 3305 4558 1867 3613 M13412 GO_CARDIOBLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIOBLAST_DIFFERENTIATION.html The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. 14/19 Gene Ontology BP GO:0010002 8.91307801820813e-06 1.03011803325192e-05 4285 3214.45454545455 3305 8.10283102622655e-07 1894 2.54473330105626 3.04574023574137 1 13.5832914866829 4284 3220 1894 2011 4000 3305 2404 2950 3414 3363 4514 3614 M13420 GO_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PHOSPHORYLATION.html The process of introducing a phosphate group on to a protein. 875/1131 Gene Ontology BP GO:0006468 7.95926579268992e-08 2.35111417040808e-07 3310 3292.36363636364 3307 7.95926607776452e-09 1583 1.89926184388162 2.08044274761632 1 13.474088743876 3307 3292 4427 2939 1583 3628 3694 3680 2443 3175 4048 3615 M16540 GO_THYROID_GLAND_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_THYROID_GLAND_DEVELOPMENT.html The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. 14/35 Gene Ontology BP GO:0030878 1.26433451437376e-07 2.93105480790615e-07 3570 2876.27272727273 3310 1.14939507912251e-08 933 1.19605904953815 -0.733284125978626 -1 8.31982838672042 3570 4547 3310 4040 1942 1843 933 1880 3469 4187 1918 3616 M11258 GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 34/46 Gene Ontology BP GO:1900739 2.75878538986674e-06 3.42492753976787e-06 2275 3192.27272727273 3311 2.50798986306489e-07 2272 1.58162242465517 1.84866346690889 1 9.21590649915344 2272 3700 3311 3797 3717 2586 2744 2708 3460 4190 2630 3617 M14844 GO_STEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 11/19 Gene Ontology BP GO:0016127 7.30079499101051e-07 1.07934128690109e-06 4000 3395.81818181818 3311 6.63708855801089e-08 1348 2.98383651941323 -2.68695147155387 -1 19.1016245334809 3998 3242 1348 3311 3113 4126 4625 3268 3962 1791 4570 3618 M11661 GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. 34/46 Gene Ontology BP GO:1900740 2.75878538986674e-06 3.42492753976787e-06 2275 3180.18181818182 3312 2.50798986306489e-07 2273 1.58162242465517 1.84866346690889 1 9.21590649915344 2273 3701 3312 3798 3718 2587 2745 2565 3461 4191 2631 3619 M11799 GO_LIPID_DIGESTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LIPID_DIGESTION.html The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. 17/42 Gene Ontology BP GO:0044241 6.2672315584754e-08 2.12948256567067e-07 3315 3039.63636363636 3312 5.69748339728424e-09 716 4.36580977472286 -4.60592273215548 -1 31.322202357498 3312 3767 716 4083 1253 4361 3824 3608 3181 2126 3205 3620 M15450 GO_CHOLESTEROL_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHOLESTEROL_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 11/19 Gene Ontology BP GO:0006707 7.30079499101051e-07 1.07934128690109e-06 4000 3400.18181818182 3312 6.63708855801089e-08 1349 2.98383651941323 -2.68695147155387 -1 19.1016245334809 3999 3243 1349 3312 3114 4127 4626 3306 3963 1792 4571 3621 M16039 GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 27/31 Gene Ontology BP GO:1902176 1.02228433853693e-07 2.61354764004912e-07 3230 3113.18181818182 3312 9.29349441854458e-09 1754 1.37133893612209 1.66318071957078 1 9.62934961878358 3228 3440 3407 2220 1754 3321 3312 2943 3224 4069 3327 3622 M11586 GO_ACETYL_COA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYL_COA_METABOLIC_PROCESS.html The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. 22/26 Gene Ontology BP GO:0006084 0.12392822793602 0.124678496126768 2420 3444.63636363636 3314 0.0119558862743069 2380 2.33373921241357 -2.33373921241357 -1 2.16428223812381 2416 4515 3417 4242 4637 2528 2380 3103 3314 4156 3183 3623 M12301 GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEMAL_DYNEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. 41/74 Gene Ontology BP GO:0070286 1.06198432297649e-06 1.47769529151005e-06 4585 3515.63636363636 3314 9.65440759652785e-08 2188 2.02439838569861 -2.0103451555207 -1 12.6251609864796 4581 3937 2188 3975 3308 4336 4125 2908 3283 2717 3314 3624 M12894 GO_EXIT_FROM_MITOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXIT_FROM_MITOSIS.html The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. 15/16 Gene Ontology BP GO:0010458 1.08230501984871e-06 1.50327321115106e-06 3910 3274.90909090909 3315 9.83914138451289e-08 1373 1.94192881236563 -1.14478313905162 -1 12.0906121327106 3908 2907 2942 2412 3315 4060 3324 4353 1373 3120 4310 3625 M12790 GO_PROSTAGLANDIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. 28/44 Gene Ontology BP GO:0006693 1.66522605106091e-07 3.50352286070536e-07 2825 3272.54545454545 3316 1.5138419791867e-08 1984 2.21146409510028 -2.41380582529963 -1 15.2941140015697 2825 3431 1984 3884 2163 3047 3902 4443 4238 3316 2765 3626 M12875 GO_ENDOCRINE_PANCREAS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOCRINE_PANCREAS_DEVELOPMENT.html The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. 28/51 Gene Ontology BP GO:0031018 9.38374255623974e-05 9.93007826112884e-05 2945 3133.36363636364 3317 8.53103893494058e-06 1756 2.21596388754968 -2.44131820837326 -1 9.46034206530178 2943 3975 2656 1802 4382 3914 3786 3499 1756 3317 2437 3627 M13952 GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_STEM_CELL_POPULATION_MAINTENANCE.html Any process that modulates the frequency, rate or extent of stem cell population maintenance. 16/22 Gene Ontology BP GO:2000036 1.70979129693149e-05 1.91518449033703e-05 3300 3316.18181818182 3317 1.5543678047232e-06 1583 1.52373457770595 1.87939804689152 1 7.64512921063906 3300 3211 3317 3728 4130 4443 4632 1781 1583 4073 2280 3628 M15959 GO_PROSTANOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure. 28/44 Gene Ontology BP GO:0006692 1.66522605106091e-07 3.50352286070536e-07 2830 3270 3318 1.5138419791867e-08 1985 2.21146409510028 -2.41380582529963 -1 15.2941140015697 2826 3432 1985 3885 2164 3048 3903 4404 4239 3318 2766 3629 M12409 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 34/44 Gene Ontology BP GO:0033144 1.28916803055191e-05 1.46555065872417e-05 3330 3257 3320 1.1719778045011e-06 1827 1.84858249253432 1.62179072912003 1 9.53096471208288 3328 2750 3320 2950 4072 3265 2883 4066 1827 3592 3774 3630 M16706 GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. 197/236 Gene Ontology BP GO:2001235 8.23506594800633e-08 2.37677062514889e-07 3370 3212.81818181818 3321 7.48642386932936e-09 1530 1.73736075556894 1.83012377985707 1 12.3070217005027 3368 3321 3282 2621 1530 2963 3546 4112 2325 3871 4402 3631 M11253 GO_PHOTOTRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOTOTRANSDUCTION.html The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. 31/64 Gene Ontology BP GO:0007602 2.67807743221861e-08 1.97691467186943e-07 4205 2878.63636363636 3323 2.43461587710824e-09 312 2.05775087653605 1.77995184686993 1 14.7751021047811 4202 1857 1719 4090 312 4144 3999 2059 3870 2090 3323 3632 M13854 GO_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_RECOMBINATION.html Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. 191/230 Gene Ontology BP GO:0006310 9.67030099623013e-06 1.11210851545869e-05 235 2538.36363636364 3323 8.79122136653022e-07 234 1.19743627055598 1.29178410619229 1 6.28882042449687 234 3323 4140 3815 4019 702 375 1641 3673 4170 1830 3633 M11818 GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrate derivative. 962/1241 Gene Ontology BP GO:1901135 2.13494550214457e-08 1.97691467186943e-07 3920 3076.45454545455 3325 2.13494552265553e-09 204 1.99644215889125 -1.62283482864142 -1 14.3315224434407 3919 2974 4327 3016 204 3325 3568 4504 2063 1461 4480 3634 M14918 GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RHODOPSIN_MEDIATED_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. 16/34 Gene Ontology BP GO:0022400 1.1074542107291e-06 1.53408289446933e-06 2225 3089.36363636364 3325 1.00677706200814e-07 647 1.14101335910949 1.12830099631755 1 7.04655003116008 2223 4254 3603 3978 3325 2201 647 2629 4113 4075 2935 3635 M10329 GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. 78/108 Gene Ontology BP GO:0009132 4.98194240118776e-08 2.02079099099266e-07 3960 3242.63636363636 3327 4.52903864909528e-09 1007 1.54805286655453 -1.3538912675466 -1 11.0714171683297 3956 3034 3335 4126 1007 3327 3527 3253 3297 2728 4079 3636 M13731 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS.html Any process that activates or increases the frequency, rate or extent of phagocytosis. 65/79 Gene Ontology BP GO:0050766 2.07800139185604e-08 1.97691467186943e-07 3685 2494.63636363636 3328 1.88909219225793e-09 138 2.2642957354568 2.2839481471861 1 16.2694915177591 3685 279 951 3039 138 4122 4467 3328 3436 607 3389 3637 M15278 GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. 187/372 Gene Ontology BP GO:0071824 1.36214179903916e-06 1.83127587140399e-06 1280 2939.54545454545 3328 1.23831149310663e-07 1277 1.68242690874759 1.43315157379253 1 10.3041814103908 1277 4103 3752 3766 3429 1583 2676 1952 3328 3678 2791 3638 M14682 GO_KIDNEY_MESENCHYME_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_KIDNEY_MESENCHYME_DEVELOPMENT.html The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. 15/27 Gene Ontology BP GO:0072074 1.37777964784694e-06 1.85069535260733e-06 4300 2821.18181818182 3329 1.2525277370007e-07 441 3.55985621348711 -2.99465269584553 -1 21.9112791978071 4300 2501 1304 1003 3432 4254 3329 4412 441 2197 3860 3639 M12341 GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 18/19 Gene Ontology BP GO:0033160 0.000159120304002015 0.000166341670303612 3265 3629.18181818182 3330 1.44665285388291e-05 2360 1.70131693465234 1.13833266691968 1 6.82557818005996 3263 4541 3234 2669 4439 3322 2360 4573 3330 3999 4191 3640 M13765 GO_REGULATION_OF_GROWTH_HORMONE_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GROWTH_HORMONE_SECRETION.html Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell. 11/17 Gene Ontology BP GO:0060123 5.86222627820672e-07 8.99635187087594e-07 3145 3326.72727272727 3330 5.32929803662221e-08 2693 1.10610085505533 -1.2204096552654 -1 7.10416817928333 3143 3826 3489 3747 2992 3172 3330 2797 4062 3343 2693 3641 M10727 GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BONE_RESORPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. 10/15 Gene Ontology BP GO:0045779 1.12358820191178e-06 1.55411887737679e-06 4425 3210.54545454545 3331 1.02144434159392e-07 1555 2.66512750153034 -1.83851602869503 -1 16.5938752103234 4422 2556 1699 1555 3331 4619 4347 3620 2621 2070 4476 3642 M11242 GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_CYTOTOXICITY.html The directed killing of a target cell by a leukocyte. 34/73 Gene Ontology BP GO:0001909 2.386108517347e-06 3.01045632625151e-06 3335 3348.72727272727 3332 2.16919191391979e-07 2429 1.80889240743638 -1.4560240816004 -1 10.66579153865 3332 3955 2963 4129 3658 3297 3729 2429 3797 2830 2717 3643 M16193 GO_PROTEIN_TETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TETRAMERIZATION.html The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. 124/176 Gene Ontology BP GO:0051262 4.96528950598649e-08 2.01777223330613e-07 3335 2776.54545454545 3332 4.51389965277325e-09 31 1.84915904463778 2.13075262060872 1 13.2481725013189 3750 31 2532 3332 1004 3676 4541 3335 1810 2061 4470 3644 M15308 GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAGNESIUM_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of magnesium ion across a membrane. 17/18 Gene Ontology BP GO:1903830 3.77255018590502e-06 4.56770127895292e-06 4620 3137.45454545455 3333 3.42959695915707e-07 1468 1.60111450867611 1.44756635619261 1 9.11480148144446 4617 1990 2507 3333 3816 4277 3671 1875 1468 3700 3258 3645 M10669 GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EPIDERMIS_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of epidermis development. 72/90 Gene Ontology BP GO:0045682 1.1316761137514e-06 1.5639111842249e-06 4545 3139.63636363636 3334 1.02879699625819e-07 819 2.7675671537607 3.16095393023385 1 17.2278943793431 4544 2670 819 3055 3334 4398 4508 4053 1280 1776 4099 3646 M14912 GO_TETRAHYDROFOLATE_INTERCONVERSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TETRAHYDROFOLATE_INTERCONVERSION.html The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. 12/13 Gene Ontology BP GO:0035999 2.07011469905707e-06 2.64913192923887e-06 2500 3217.09090909091 3335 1.88192422450664e-07 2054 1.21186116567257 1.3986765831658 1 7.18080645748157 2498 2054 3271 3659 3603 4279 3898 2348 3368 3075 3335 3647 M12223 GO_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 76/79 Gene Ontology BP GO:0032204 1.13595044986696e-05 1.29675599686726e-05 1095 2917.90909090909 3336 1.03268755935324e-06 681 1.23017602196739 1.2626952991679 1 6.37529008683983 1091 4145 4074 4060 4052 1379 681 2208 3336 4480 2591 3648 M13386 GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. 125/164 Gene Ontology BP GO:0016051 3.3386855954639e-08 1.97691467186943e-07 4065 2715.27272727273 3336 3.03516876921024e-09 40 1.71734142795446 -1.47962083037771 -1 12.3121781729235 4065 40 2563 3593 533 3336 3572 3655 2243 2497 3771 3649 M11148 GO_OXIDATIVE_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_DEMETHYLATION.html The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. 9/41 Gene Ontology BP GO:0070989 1.00349017954977e-06 1.40851879500605e-06 3105 3030.72727272727 3337 1.0034906326967e-07 85 3.3333152890462 -5.132945803911 -1 20.9362535355618 3104 4068 4280 3337 3323 3927 4008 1280 85 3898 2028 3650 M16707 GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NFAT_PROTEIN_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus. 11/13 Gene Ontology BP GO:0051533 1.54270490854152e-05 1.73890647757841e-05 3530 3327.63636363636 3337 1.4024688423179e-06 2071 1.60899560544701 -1.34319745511046 -1 8.15206131244581 3526 2944 3291 3219 4105 4004 4187 2071 2173 3747 3337 3651 M12515 GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 15/25 Gene Ontology BP GO:0070875 2.70738269230259e-05 2.97179798709223e-05 2440 3318.63636363636 3340 2.46128728245414e-06 2101 1.58419731274519 1.89715978816152 1 7.62675191686049 2439 4272 3123 4212 4218 3340 2369 2101 4316 3818 2297 3652 M14494 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS.html Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. 31/67 Gene Ontology BP GO:0002833 6.81814403911518e-06 7.9750689326302e-06 1185 2923.27272727273 3340 6.19833197245588e-07 1184 1.29110660627795 -1.42498029175264 -1 6.99084029436658 1184 3963 3340 4407 3950 1482 1437 2548 4107 3591 2147 3653 M10818 GO_RNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_STABILIZATION.html Prevention of degradation of RNA molecules. 38/44 Gene Ontology BP GO:0043489 1.14329393780341e-06 1.57622124225164e-06 3940 2914.45454545455 3341 1.03935866540888e-07 1455 1.39109432298805 1.31982352976319 1 8.59809383606617 1715 3940 3610 3936 3341 1577 1455 2912 3443 3443 2687 3654 M10723 GO_MEMBRANE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_DISASSEMBLY.html The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. 54/57 Gene Ontology BP GO:0030397 1.54189575216809e-06 2.0376145796189e-06 935 2731.54545454545 3343 1.40172439347713e-07 844 1.29525865429423 1.15062068574913 1 7.84208907907713 931 3374 3789 3526 3487 1236 844 2571 3343 4062 2884 3655 M11071 GO_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_DEATH.html Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). 1128/1569 Gene Ontology BP GO:0008219 2.70807574059547e-08 1.97691467186943e-07 3645 2767.54545454545 3344 2.708075773597e-09 402 1.98322231191266 -1.80479761021187 -1 14.2358744594182 3642 2102 4277 1690 402 3440 3344 4020 1749 1205 4572 3656 M11543 GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule. 23/32 Gene Ontology BP GO:0046131 3.98307204638626e-07 6.63322628197397e-07 4150 3023.36363636364 3344 3.62097524319688e-08 803 1.32122156225452 -0.826725728524186 -1 8.69652901620561 4150 803 3213 3344 2758 3381 3013 3450 1100 3409 4636 3657 M13722 GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 116/172 Gene Ontology BP GO:0010906 1.74526811982685e-06 2.27280508299869e-06 4155 3424.27272727273 3344 1.58660864032366e-07 2679 1.77286391902148 -1.19929208335512 -1 10.6846642906813 4152 3344 3178 3748 3543 4100 3283 2679 2932 3635 3073 3658 M13975 GO_MUSCLE_ATROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MUSCLE_ATROPHY.html A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. 11/18 Gene Ontology BP GO:0014889 0.000836858260761897 0.000859960575822682 3130 3440.18181818182 3344 7.61069784549961e-05 2216 2.19649314151314 -2.60570928335983 -1 7.15379617537008 3130 4295 2867 3962 4520 3866 3216 2216 3779 3344 2647 3659 M15629 GO_NUCLEAR_ENVELOPE_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_DISASSEMBLY.html The controlled breakdown of the nuclear envelope in the context of a normal process. 54/57 Gene Ontology BP GO:0051081 1.54189575216809e-06 2.0376145796189e-06 935 2736.36363636364 3344 1.40172439347713e-07 845 1.29525865429423 1.15062068574913 1 7.84208907907713 932 3375 3790 3527 3488 1237 845 2613 3344 4064 2885 3660 M10265 GO_PROTEIN_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXPORT_FROM_NUCLEUS.html The directed movement of a protein from the nucleus into the cytoplasm. 51/55 Gene Ontology BP GO:0006611 7.30048757684241e-07 1.07934128690109e-06 2030 2883.09090909091 3345 6.63680909039986e-08 329 1.17691360511683 1.19641764870576 1 7.46575854812808 2027 3923 3947 3567 3112 1291 1544 3345 4318 4311 329 3661 M13523 GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. 4/19 Gene Ontology BP GO:0006704 1.60460421166267e-05 1.80212971201217e-05 2750 3088.54545454545 3346 1.60461579817646e-06 432 3.93368034557272 4.90830000924518 1 20.0277589058822 2748 3577 4432 2796 4137 3646 3695 432 2950 2215 3346 3662 M11057 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 11/14 Gene Ontology BP GO:0033147 1.63455854063458e-05 1.83532839999341e-05 3350 3233 3348 1.48597335020257e-06 139 1.92210109630983 2.0177461709581 1 9.71181660469329 3348 3259 3049 2911 4121 3596 4266 4285 139 3736 2853 3663 M12960 GO_RESPONSE_TO_STEROL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STEROL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. 37/45 Gene Ontology BP GO:0036314 2.51143989602674e-08 1.97691467186943e-07 3815 2892.63636363636 3349 2.28312720426947e-09 268 2.16679995460242 2.49671088717437 1 15.5640919087826 3814 2334 1750 1259 268 4501 4596 4551 3740 1657 3349 3664 M13042 GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar. 18/21 Gene Ontology BP GO:0009200 4.17867215445364e-08 1.97691467186943e-07 4570 3386.27272727273 3349 3.79879293983927e-09 780 1.40763620223939 -1.08447530535348 -1 10.0714048471145 4568 2867 3216 4366 780 4157 3349 3181 3526 2761 4478 3665 M14227 GO_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of B cell activation. 102/269 Gene Ontology BP GO:0050864 1.82242426477883e-07 3.73721467783864e-07 2880 3094.18181818182 3349 1.65674946885805e-08 1636 1.96445924858566 -1.99131711371692 -1 13.5137834574436 2879 3349 2149 3388 2226 3616 4520 3834 3968 1636 2471 3666 M10629 GO_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 44/53 Gene Ontology BP GO:0070670 1.24359647738566e-06 1.69591278114757e-06 3120 3014.45454545455 3350 1.13054289123218e-07 1622 2.02974793778662 -2.54058127785673 -1 12.5277855791059 3117 3680 2181 3350 3377 3369 3485 2257 3271 3450 1622 3667 M12633 GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 12/15 Gene Ontology BP GO:0006244 1.73364230784157e-07 3.60278591263368e-07 3350 3373.36363636364 3350 1.57603858586903e-08 2195 1.55054166812006 -1.60753841672495 -1 10.6691808672258 3350 4276 3013 4361 2195 3531 2823 4578 2266 3069 3645 3668 M11678 GO_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a leukocyte. 147/448 Gene Ontology BP GO:0002443 1.53421281986282e-07 3.31158121836001e-07 4500 3136.18181818182 3351 1.39473902441286e-08 1468 2.12155964761145 -2.01264500283977 -1 14.7237788911133 4500 3614 1468 3351 2102 4056 3628 4062 2917 1749 3051 3669 M15957 GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE.html The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. 55/133 Gene Ontology BP GO:0002440 1.65201495077697e-07 3.48135215849875e-07 3355 3146.45454545455 3351 1.50183188620855e-08 1391 2.05380660320284 2.17483931092538 1 14.2018294160518 3351 3908 2528 3965 2160 2418 1391 3974 3899 2535 4482 3670 M10478 GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS.html Any process that modulates the frequency, rate or extent of cholesterol homeostasis. 14/18 Gene Ontology BP GO:2000188 3.75753025508807e-07 6.33247576757036e-07 3855 3230.36363636364 3352 3.4159371789659e-08 941 2.01645654372956 -1.21911531446343 -1 13.3760629083918 3855 2903 2712 2434 2725 3690 4132 4223 941 3352 4567 3671 M15039 GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. 55/65 Gene Ontology BP GO:0009066 1.05429172579948e-07 2.64761392764306e-07 3225 3336.09090909091 3353 9.58447069385112e-09 1781 1.82181448710302 1.58748446546652 1 12.8186194154303 3223 3056 3353 3107 1781 3999 4382 4159 1992 3432 4213 3672 M15578 GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. 21/31 Gene Ontology BP GO:2000353 2.69380953671046e-07 4.87526090016093e-07 4070 3038.81818181818 3354 2.44891806050583e-08 1154 3.11727780784127 -2.9822272773594 -1 21.1221460399152 4067 2818 1154 1529 2529 4317 4474 3623 3354 1640 3922 3673 M12471 GO_LAGGING_STRAND_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LAGGING_STRAND_ELONGATION.html The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. 11/11 Gene Ontology BP GO:0006273 4.96616203535979e-05 5.34278657815702e-05 1795 2742.45454545455 3356 4.51479467489239e-06 245 1.16105685472083 1.10008540202647 1 5.24021903184316 1791 3556 3356 3690 4310 1465 245 1407 4092 3741 2514 3674 M11045 GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TYPE_B_PANCREATIC_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. 14/21 Gene Ontology BP GO:0003323 0.00187497649179039 0.00191742101457157 3045 3037.72727272727 3357 0.000170597852030328 253 2.357594324917 -2.18510064623242 -1 6.80072881667288 3044 3812 2524 2151 4540 3370 3691 3300 253 3357 3373 3675 M14710 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS.html Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. 1135/1522 Gene Ontology BP GO:0031401 5.98209634229519e-08 2.09283415644357e-07 3475 2750.27272727273 3357 5.98209650332983e-09 623 2.02522816738536 2.22153396034085 1 14.4857053915216 3472 2101 4514 1361 1304 3357 3384 3435 2418 623 4284 3676 M12601 GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. 567/886 Gene Ontology BP GO:0032870 3.54532577054553e-08 1.97691467186943e-07 3670 2726.54545454545 3358 3.54532582710754e-09 708 2.08172506384948 2.23161905270853 1 14.9485596863115 3666 1248 4376 742 708 3358 3556 4416 2005 1386 4531 3677 M11879 GO_REGULATION_OF_NUCLEASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. 40/48 Gene Ontology BP GO:0032069 5.99084609583869e-07 9.14158547403981e-07 4175 3189.72727272727 3359 5.44622520655791e-08 1448 1.42951223138205 1.17799501269169 1 9.20368492819794 4175 2720 3374 1448 3006 3752 2892 2983 3359 3391 3987 3678 M16770 GO_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METABOLIC_PROCESS.html Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. 750/1006 Gene Ontology BP GO:0006259 1.07510691284097e-06 1.49506050969786e-06 1020 3015.81818181818 3359 1.07510743297601e-07 1017 1.30884631537379 1.36974694749057 1 8.11547727299296 1017 3852 4646 4334 3359 1212 1332 2484 3552 4570 2816 3679 M12857 GO_POSITIVE_REGULATION_OF_CELL_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_GROWTH.html Any process that activates or increases the frequency, rate, extent or direction of cell growth. 174/233 Gene Ontology BP GO:0030307 9.9460052255772e-08 2.57738316115422e-07 3365 2800.63636363636 3361 9.04182334111575e-09 1244 2.33529103886618 2.20981520793187 1 16.4928370867935 3361 3606 1244 1761 1728 3424 3518 3733 2249 1706 4477 3680 M13931 GO_REGULATION_OF_PROTEIN_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_STABILITY.html Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. 252/304 Gene Ontology BP GO:0031647 1.71135103761675e-07 3.57500358695115e-07 3690 3328.81818181818 3361 1.55577379158228e-08 2183 1.61401475825749 1.56472060135318 1 11.1164212389859 3690 3862 3932 2667 2183 2910 3837 2715 3361 4398 3062 3681 M12245 GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of myeloid cell differentiation. 188/290 Gene Ontology BP GO:0045637 8.8248218649368e-08 2.45879617590125e-07 3385 3062.81818181818 3364 8.02256565356851e-09 1400 2.00397895084063 -2.13538400039726 -1 14.1811645515317 3382 3000 1589 4537 1597 3720 4561 3109 3432 1400 3364 3682 M14271 GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PEPTIDYL_PROLYL_ISOMERIZATION.html The modification of a protein by cis-trans isomerization of a proline residue. 35/41 Gene Ontology BP GO:0000413 0.000557821849168608 0.000574235633668481 2115 3352.72727272727 3364 5.0723939830076e-05 2112 1.68585310422767 1.85052201421062 1 5.78349714376433 2112 4458 3364 4369 4508 2853 3399 2221 2802 3855 2939 3683 M16832 GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. 18/26 Gene Ontology BP GO:0043518 3.92925150767646e-05 4.25280466741535e-05 2530 3207.45454545455 3365 3.57211062434829e-06 1348 1.97199783826526 2.44561795644227 1 9.1901394881416 2530 4249 2872 4192 4279 2891 1348 2116 3365 3794 3646 3684 M10700 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS.html Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. 1857/2850 Gene Ontology BP GO:0048584 3.3866715049045e-09 5.92412876403031e-08 3710 2613.81818181818 3366 3.38667151006579e-10 129 2.17527040891975 2.33762568151714 1 16.8540358037047 3709 1135 4256 879 846 3877 3846 3366 2153 129 4556 3685 M13571 GO_INTERACTION_WITH_HOST http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_HOST.html An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 149/213 Gene Ontology BP GO:0051701 5.39634562445722e-08 2.05257319697064e-07 3015 3216.81818181818 3366 4.90576886983939e-09 1099 1.68107604292979 -1.51010237070401 -1 12.0201994836438 3826 3013 3011 3366 1099 3313 3759 4361 3458 2008 4171 3686 M15938 GO_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_TRANSPORT.html The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 55/104 Gene Ontology BP GO:0015908 3.95263327807779e-06 4.7646638971233e-06 4510 3317.45454545455 3366 3.59330943600011e-07 1671 2.36326587833716 -2.00205984924401 -1 13.4606391901313 4508 3366 1896 2313 3832 4592 4646 3221 1671 2534 3913 3687 M15397 GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN.html Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein. 40/68 Gene Ontology BP GO:0042516 1.26883860542658e-06 1.72533854312767e-06 4025 3152.09090909091 3367 1.15349030656661e-07 1467 2.02880809833911 -1.70200821966933 -1 12.5055746970778 4025 2725 2279 2026 3387 4457 4586 3367 2699 1467 3655 3688 M14713 GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_BRANCHED_CHAIN_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. 27/27 Gene Ontology BP GO:0009081 6.48155933430176e-05 6.936222535075e-05 3315 3081.54545454545 3369 5.89250027227543e-06 566 1.28914046498838 -0.869342541583665 -1 5.67306872830014 3314 3437 3513 3914 4337 2844 3369 2889 566 4068 1646 3689 M13668 GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. 463/607 Gene Ontology BP GO:0033157 7.06031314696048e-08 2.22874064265991e-07 3515 3238.27272727273 3371 6.41846670322036e-09 1379 1.74003113219868 1.90149586484607 1 12.3785572028349 3515 3590 3711 2673 1379 3351 3362 3371 2136 4141 4392 3690 M15572 GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CYTOPLASMIC_TRANSLATION.html Any process that modulates the frequency, rate or extent of cytoplasmic translation. 17/17 Gene Ontology BP GO:2000765 3.50641464227443e-07 5.99608501672287e-07 4545 3432.45454545455 3372 3.18765018285058e-08 2134 1.17234473418895 -1.20608817896057 -1 7.75933901863621 4543 2496 3308 3372 2682 4540 4250 3549 2134 3949 2934 3691 M12660 GO_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_APOPTOTIC_SIGNALING_PATHWAY.html A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. 340/446 Gene Ontology BP GO:0097190 5.32048249583206e-08 2.04903449305918e-07 4335 3357 3373 4.83680238591154e-09 1083 1.77870461262772 -1.56565125070748 -1 12.7262798264889 4331 2987 3265 2628 1083 4461 4274 4483 2392 3373 3650 3692 M11655 GO_UV_PROTECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_UV_PROTECTION.html Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. 12/13 Gene Ontology BP GO:0009650 5.85710993525206e-07 8.99443317779797e-07 3525 3283.90909090909 3375 5.32464681327665e-08 2309 1.01404204600751 1.23811720984962 1 6.50358934120782 3524 2937 3516 3184 2990 3403 2309 2486 4106 4293 3375 3693 M11426 GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. 75/88 Gene Ontology BP GO:1903363 5.43225266005352e-08 2.05617623085131e-07 3465 2919 3376 4.9384116310791e-09 1105 1.43492201388976 1.42460020698274 1 10.2423840736952 3461 2666 3633 2613 1105 3376 3684 2816 1413 3579 3763 3694 M11770 GO_POSITIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_BINDING.html Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 54/70 Gene Ontology BP GO:0043388 8.69146059745255e-07 1.25011951035384e-06 2310 3211.81818181818 3376 7.90133093741673e-08 2081 1.4824709255351 -1.46976330278089 -1 9.33136246735681 2309 3913 3376 3816 3202 2352 3461 2081 4066 4063 2691 3695 M16322 GO_REGULATION_OF_MYOBLAST_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_PROLIFERATION.html Any process that modulates the frequency, rate or extent of myoblast proliferation. 10/25 Gene Ontology BP GO:2000291 4.32560583556315e-05 4.67201577364794e-05 3890 3271 3379 3.93244626117686e-06 2086 2.53909406242193 -2.07698848448644 -1 11.7536308215445 3889 3257 2134 3379 4291 3843 4415 4102 2388 2086 2197 3696 M11477 GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 17/20 Gene Ontology BP GO:0010763 4.68436160010918e-05 5.05012384738369e-05 3695 3409.54545454545 3382 4.25860122281719e-06 2610 2.27171543859063 -1.30543559406615 -1 10.4211460168694 3693 3782 2986 2984 4298 3250 2866 4070 2610 3382 3584 3697 M16866 GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_S_ADENOSYLHOMOCYSTEINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. 13/14 Gene Ontology BP GO:0046498 1.23779461517519e-07 2.89711184326466e-07 4080 2903.90909090909 3382 1.12526789528883e-08 334 1.79597004833833 0.94716574382573 1 12.5593619997867 4076 4050 3056 3382 1926 4143 4399 334 410 3930 2237 3698 M15834 GO_CYTOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOLYSIS.html The rupture of cell membranes and the loss of cytoplasm. 22/49 Gene Ontology BP GO:0019835 8.90291631782591e-08 2.46432299981225e-07 3690 2634.72727272727 3384 8.09356061646125e-09 826 3.22806539997546 -3.09397888914497 -1 22.9091030367198 3686 832 826 2249 1609 3782 4613 3555 3384 911 3535 3699 M16077 GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 674/855 Gene Ontology BP GO:1903827 5.48255077217524e-08 2.05617623085131e-07 3245 3118.72727272727 3384 5.48255090743788e-09 1224 1.74062727082377 1.88100036359534 1 12.4485842574018 3243 2114 4592 2219 1224 3384 3438 3750 2197 3875 4270 3700 M16221 GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA http://www.broadinstitute.org/gsea/msigdb/cards/GO_BINDING_OF_SPERM_TO_ZONA_PELLUCIDA.html The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. 28/60 Gene Ontology BP GO:0007339 0.000142597536198825 0.000149438363948904 3290 3318.72727272727 3384 1.29642527082697e-05 1683 1.63418734490707 1.60761747387073 1 6.63387507015756 3287 3972 3384 2461 4425 2373 1683 4336 4110 3809 2666 3701 M11524 GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOTRIENE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. 11/20 Gene Ontology BP GO:0019370 6.4244954366075e-05 6.87673735139975e-05 2530 3218.81818181818 3385 5.84062095819323e-06 1627 1.7127471898251 1.24247994762015 1 7.58129560210638 2529 3255 2885 4513 4336 3592 1686 1627 3861 3738 3385 3702 M12306 GO_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAST_CELL_ACTIVATION.html The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. 17/42 Gene Ontology BP GO:0045576 1.97383807997865e-06 2.53429044871431e-06 4055 3240.27272727273 3385 1.79439986446061e-07 1223 2.10348579224183 -2.34777767341179 -1 12.5909770244207 4052 2864 1986 3647 3590 4462 3836 1223 3219 3385 3379 3703 M12765 GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_NITROGEN_SPECIES_METABOLIC_PROCESS.html The chemical reactions and pathways involving a reactive nitrogen species. 19/26 Gene Ontology BP GO:2001057 0.00025133415582035 0.000260981438748514 2580 3414.27272727273 3385 2.28511703209802e-05 2374 2.02682900182473 -2.21137163806645 -1 7.72527372858013 2578 4512 3031 3919 4469 2616 3023 3385 4042 3608 2374 3704 M16267 GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. 224/307 Gene Ontology BP GO:0040029 6.88475097869026e-07 1.02741328748704e-06 2490 3477.81818181818 3385 6.25886648475216e-08 2053 1.50081425661506 1.51691601417247 1 9.5862342969019 2486 4334 4022 4311 3082 3385 3112 2053 3686 4431 3354 3705 M13875 GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION.html Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. 76/104 Gene Ontology BP GO:0045639 7.23695778257861e-08 2.25241234530691e-07 4200 3044.18181818182 3389 6.5790527460366e-09 1402 2.07666346731041 -2.46527294518943 -1 14.7849517518625 4199 2668 1701 2952 1402 4516 3953 3389 3525 1515 3666 3706 M16382 GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_B_CELL_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. 43/171 Gene Ontology BP GO:0050853 1.4415530308495e-07 3.18648278030533e-07 4340 3329.72727272727 3391 1.31050284118861e-08 1723 2.31392386922587 -2.56090985606476 -1 16.1108190879104 4338 3391 1723 3381 2049 4522 3952 2676 4210 2643 3742 3707 M13478 GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_OR_FLAGELLUM_DEPENDENT_CELL_MOTILITY.html Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. 18/26 Gene Ontology BP GO:0001539 9.25351018002038e-08 2.50183514628907e-07 3345 3206.63636363636 3392 8.41228233566919e-09 1653 2.19197928848981 2.55699278330572 1 15.504331797131 3343 3759 2201 3878 1653 3392 3791 3958 2503 2763 4032 3708 M12917 GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_ACETYLGLUCOSAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. 12/17 Gene Ontology BP GO:0006044 5.99450493999974e-07 9.14158547403981e-07 4295 3484.72727272727 3393 5.4495514303346e-08 2542 1.3209853392141 -0.945071435027743 -1 8.49636571858362 4293 2542 3093 3393 3008 3957 4270 4150 3153 2554 3919 3709 M16439 GO_DOPAMINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOPAMINE_TRANSPORT.html The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. 6/13 Gene Ontology BP GO:0015872 1.16695257583081e-06 1.60361203052001e-06 4330 3091.09090909091 3394 1.1669531886315e-07 847 2.6645032393036 -1.6016813150836 -1 16.5508101669439 4330 1115 4622 1926 3394 4438 4404 2610 847 2173 4143 3710 M16786 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. 18/19 Gene Ontology BP GO:1990440 6.38131231555672e-06 7.48292495067677e-06 3065 3390.90909090909 3394 5.801209841131e-07 2331 2.18054132512959 2.70296407356576 1 11.9497954391133 3062 3770 2331 2661 3940 3247 3394 3170 3905 3489 4331 3711 M10935 GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. 24/26 Gene Ontology BP GO:0071498 1.30016491991708e-06 1.75964728690348e-06 3530 3175.36363636364 3395 1.18196880754041e-07 2344 2.37346508053469 2.22198843675773 1 14.6273494978035 3527 2418 2344 3512 3402 3395 2450 3479 2974 3213 4215 3712 M15781 GO_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 40/56 Gene Ontology BP GO:0046686 7.50243299371758e-08 2.28689428729205e-07 3825 3445.09090909091 3397 6.82039386324118e-09 1432 1.93608408886891 -2.27631942597914 -1 13.7626440356804 3823 3397 2461 3387 1432 4332 4337 4642 3160 3392 3533 3713 M12679 GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRIMARY_AMINO_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving primary amino compound. 14/25 Gene Ontology BP GO:1901160 2.15338545060904e-06 2.74362061930007e-06 3445 2919.81818181818 3399 1.95762505306411e-07 962 2.77392826819541 2.21418663731096 1 16.5369511538458 3445 3527 2114 3609 3622 3399 3784 3247 962 2488 1921 3714 M11995 GO_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOKINE_PRODUCTION.html The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 118/201 Gene Ontology BP GO:0001816 2.66115061649913e-07 4.82225141198923e-07 3790 2631.72727272727 3400 2.41922812581424e-08 57 2.34937609661132 2.45106993227111 1 15.9031527165574 3788 57 731 1958 2525 3437 3635 3764 3400 1128 4526 3715 M12056 GO_PEPTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 554/740 Gene Ontology BP GO:0006518 1.64826378277675e-07 3.47659627436999e-07 2130 3487.72727272727 3400 1.64826390503156e-08 2127 1.30610009278287 -1.23279614991115 -1 8.99119010312693 2127 4612 4340 4346 2222 3021 2876 2999 3801 4621 3400 3716 M12185 GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. 20/33 Gene Ontology BP GO:1903409 3.04125640009392e-07 5.35818478971489e-07 3710 3484.18181818182 3400 2.76477892774002e-08 2602 2.41319778034367 1.94990199273421 1 16.2190424590831 3708 4231 2736 3380 2602 3051 2913 4637 3763 3400 3905 3717 M12850 GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. 18/18 Gene Ontology BP GO:0035024 5.30468815529171e-07 8.27723473728113e-07 3400 3398.72727272727 3400 4.82244494033651e-08 2662 2.11317593065617 1.71823327695775 1 13.7578095830254 3400 2863 2662 3377 2946 3497 3927 4106 3805 3160 3643 3718 M16891 GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NEUTROPHIL_CHEMOTAXIS.html Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. 27/55 Gene Ontology BP GO:0090022 1.30267213897686e-06 1.7625279042336e-06 4480 2995.54545454545 3403 1.18424810029141e-07 824 2.56779730730934 -2.62747227604829 -1 15.8322846241137 4477 3115 1213 1891 3403 4062 3442 3796 3229 824 3499 3719 M12479 GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 beta production. 41/76 Gene Ontology BP GO:0032651 8.73848206486762e-05 9.27678691485946e-05 3015 3489.54545454545 3404 7.94439016357964e-06 2689 1.79906897481803 1.6763736281302 1 7.71665105175559 3013 3939 2689 3781 4370 3786 3404 3282 4252 2718 3151 3720 M12685 GO_PROTEIN_K11_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K11_LINKED_UBIQUITINATION.html A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. 30/35 Gene Ontology BP GO:0070979 1.30489556795675e-06 1.7650229877043e-06 780 2619.72727272727 3404 1.1862694017598e-07 270 0.838688809616672 0.877166430907054 1 5.09439504064242 780 3714 3993 4452 3404 585 270 1543 4335 4429 1312 3721 M16552 GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_CELL_APOPTOTIC_PROCESS.html Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. 14/18 Gene Ontology BP GO:0010661 2.33187995850171e-06 2.94763310157796e-06 4605 3305.72727272727 3404 2.11989311833718e-07 2041 2.21433349035489 -3.08779469646609 -1 13.1036353241655 4604 2041 2152 3404 3650 4605 3120 4437 2155 2493 3702 3722 M16613 GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. 20/21 Gene Ontology BP GO:0034616 5.25953719396027e-07 8.23162682929604e-07 4405 3456.27272727273 3404 4.78139859214325e-08 2163 1.49005735930745 -1.40119624203364 -1 9.6715120822621 4403 3165 3259 3507 2938 3696 2687 2163 4553 3404 4244 3723 M12270 GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT.html Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. 97/124 Gene Ontology BP GO:0090317 1.56064243811404e-08 1.97691467186943e-07 3940 2808 3405 1.41876586289543e-09 42 1.72773621007676 -1.29233932658928 -1 12.3873863017288 3936 117 3106 3405 42 3961 3835 3854 1769 3565 3298 3724 M13124 GO_REGULATION_OF_MAST_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MAST_CELL_ACTIVATION.html Any process that modulates the frequency, rate, or extent of mast cell activation. 37/56 Gene Ontology BP GO:0033003 1.38403573988493e-07 3.10507150322305e-07 3785 3233.72727272727 3405 1.25821438814147e-08 1818 1.64005770077211 -1.36851972693634 -1 11.4059479403487 3781 1818 2836 2565 2017 3805 4200 4281 3405 2232 4631 3725 M16259 GO_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. 1673/2309 Gene Ontology BP GO:0009056 2.74021950910388e-08 1.97691467186943e-07 3135 3364.90909090909 3405 2.7402195428935e-09 414 1.79699143324651 -1.56852929604376 -1 12.8884603678619 3135 4084 4609 4494 414 2529 3327 4219 2354 4444 3405 3726 M16796 GO_SPLEEN_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLEEN_DEVELOPMENT.html The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. 37/48 Gene Ontology BP GO:0048536 6.88850350094454e-08 2.20745225825723e-07 4055 3362.72727272727 3406 6.26227610603007e-09 1359 1.53065706118876 -1.41630830642307 -1 10.8823498001623 4051 3406 3273 2879 1359 3750 4063 4396 2478 3378 3957 3727 M10692 GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_INTESTINAL_BARRIER.html The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 15/16 Gene Ontology BP GO:0090557 1.76996980569895e-05 1.98020425725348e-05 2850 3479.81818181818 3408 1.60907640529822e-06 2849 2.2587678227991 -1.66037770547255 -1 11.3522691862077 3408 4255 2850 3051 4138 3950 3727 3391 2849 3468 3191 3728 M11412 GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. 1467/2173 Gene Ontology BP GO:0051172 1.19813973829579e-07 2.84948968717509e-07 3345 3544.36363636364 3408 1.19813980289504e-08 1979 1.69317406578465 1.84143391887431 1 11.8471815204521 3342 4086 4298 4285 1979 3387 2972 3408 3078 4140 4013 3729 M14008 GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. 107/154 Gene Ontology BP GO:2000117 9.42426160234537e-08 2.51439731856152e-07 2890 3420.36363636364 3408 8.56751091459788e-09 1677 1.89910467953532 1.69651517068139 1 13.4131984554229 2886 4121 2987 3981 1677 3356 3122 3610 3408 3910 4566 3730 M16186 GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glycosyl compound. 34/46 Gene Ontology BP GO:1901658 1.25922436724489e-06 1.71471202247307e-06 4625 3223.18181818182 3408 1.14475007999423e-07 640 2.16732995185864 2.71904100092972 1 13.3734215123985 4621 3408 2347 2709 3383 4077 3516 4190 640 2158 4406 3731 M14020 GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. 154/231 Gene Ontology BP GO:0072330 4.15829258997838e-08 1.97691467186943e-07 4365 2971.18181818182 3409 3.7802660623415e-09 608 2.43633841697747 2.46163169525963 1 17.5142514366856 4361 2623 608 3855 773 4576 3973 3409 3029 931 4545 3732 M15724 GO_LONG_CHAIN_FATTY_ACID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LONG_CHAIN_FATTY_ACID_TRANSPORT.html The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. 37/73 Gene Ontology BP GO:0015909 5.13613559283745e-06 6.09498569586143e-06 3325 3318.54545454545 3409 4.66922507612291e-07 2089 2.19094547364107 -1.48846403906288 -1 12.2180290486018 3325 3409 2395 2889 3894 3816 3905 4312 2089 2855 3615 3733 M10942 GO_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALPHA_BETA_T_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. 39/56 Gene Ontology BP GO:0046632 1.32911232265879e-06 1.79360778344877e-06 3435 3148.18181818182 3413 1.20828465966546e-07 2162 2.14430346548969 -1.95288796932601 -1 13.1849250510217 3434 2726 2313 2429 3413 3748 4353 3002 3474 2162 3576 3734 M11340 GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. 21/29 Gene Ontology BP GO:0095500 2.36165429762602e-07 4.41848711172251e-07 4165 3237.63636363636 3413 2.14695868285886e-08 1049 2.09900753706772 2.61240436158555 1 14.2823594392975 4163 2820 2442 3610 2435 4365 3413 4290 1049 3180 3847 3735 M16539 GO_UTERUS_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTERUS_DEVELOPMENT.html The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. 16/24 Gene Ontology BP GO:0060065 6.85408016015655e-06 8.01508795808203e-06 3415 2893.27272727273 3413 6.23100137643146e-07 245 2.39038474807752 -2.17356077661327 -1 13.0336899839284 3413 4259 2308 2007 3986 3895 4428 245 4037 2411 837 3736 M11878 GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_CELLULAR_RESPONSE_TO_AMMONIUM_ION.html Any signal transduction that is involved in cellular response to ammonium ion. 21/29 Gene Ontology BP GO:1903831 2.36165429762602e-07 4.41848711172251e-07 4165 3237.54545454545 3414 2.14695868285886e-08 1050 2.09900753706772 2.61240436158555 1 14.2823594392975 4164 2821 2443 3611 2436 4366 3414 4278 1050 3182 3848 3737 M11936 GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. 87/142 Gene Ontology BP GO:0019217 4.22747607723919e-07 6.91404083915429e-07 4610 3558 3414 3.84316080871161e-08 2034 1.71108154272881 -1.28535370709034 -1 11.2627802171018 4610 3356 3414 2034 2810 4621 4160 4351 3049 3452 3281 3738 M12189 GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 21/29 Gene Ontology BP GO:1905145 2.36165429762602e-07 4.41848711172251e-07 4165 3244.27272727273 3415 2.14695868285886e-08 1051 2.09900753706772 2.61240436158555 1 14.2823594392975 4165 2822 2444 3612 2437 4367 3415 4342 1051 3183 3849 3739 M13017 GO_REGULATION_OF_LIPID_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIPID_KINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. 66/99 Gene Ontology BP GO:0043550 1.05147233119124e-07 2.64711738989803e-07 4615 3100.72727272727 3416 9.55883983132294e-09 321 1.97890178374091 -1.85205006283549 -1 13.9338402162861 4613 3042 2375 321 1777 4418 4214 4060 1811 3416 4061 3740 M13242 GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_ACETYLCHOLINE_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. 21/29 Gene Ontology BP GO:0007213 2.36165429762602e-07 4.41848711172251e-07 4170 3243.27272727273 3416 2.14695868285886e-08 1052 2.09900753706772 2.61240436158555 1 14.2823594392975 4166 2823 2445 3613 2438 4368 3416 4319 1052 3186 3850 3741 M16403 GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. 22/29 Gene Ontology BP GO:0048384 1.38925777287502e-07 3.11096528367132e-07 4550 3184.90909090909 3416 1.26296169145817e-08 1722 2.44128203364584 1.81045292334303 1 17.0312262334974 4549 4215 2551 3416 2023 4448 3606 1722 2069 2589 3846 3742 M14251 GO_RESPONSE_TO_ACETYLCHOLINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACETYLCHOLINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. 21/29 Gene Ontology BP GO:1905144 2.36165429762602e-07 4.41848711172251e-07 4170 3244.81818181818 3417 2.14695868285886e-08 1053 2.09900753706772 2.61240436158555 1 14.2823594392975 4167 2824 2446 3614 2439 4369 3417 4325 1053 3188 3851 3743 M11721 GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. 75/133 Gene Ontology BP GO:0045913 1.53392657987071e-07 3.31158121836001e-07 2260 3224.72727272727 3418 1.39447880620193e-08 2101 1.88897964521898 -1.57473203949967 -1 13.0972581413239 4513 2260 2568 3725 2101 4125 2291 4564 3418 2260 3647 3744 M15706 GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTSYNAPTIC_SIGNAL_TRANSDUCTION.html Signal transduction in which the initial step occurs in a postsynapse. 21/29 Gene Ontology BP GO:0098926 2.36165429762602e-07 4.41848711172251e-07 4170 3246 3418 2.14695868285886e-08 1054 2.09900753706772 2.61240436158555 1 14.2823594392975 4168 2825 2447 3615 2440 4370 3418 4327 1054 3190 3852 3745 M11293 GO_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 585/702 Gene Ontology BP GO:0030163 4.68704351419036e-08 1.98252330758246e-07 3230 3457.18181818182 3420 4.68704361304805e-09 1041 1.49586826183449 -1.32128695488424 -1 10.7077934508259 3227 4609 4292 4605 1041 2711 3234 4585 1791 4514 3420 3746 M16462 GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT.html The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. 142/166 Gene Ontology BP GO:0030705 8.97062078266615e-08 2.4756997925116e-07 3425 3316.81818181818 3421 8.15511013495284e-09 1616 1.47375876213473 1.5748283892226 1 10.3944030607454 3421 2196 3655 3323 1616 3969 4633 4539 2338 3544 3251 3747 M11012 GO_CELL_CYCLE_PHASE_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_CYCLE_PHASE_TRANSITION.html The cell cycle process by which a cell commits to entering the next cell cycle phase. 311/387 Gene Ontology BP GO:0044770 1.71160411884305e-06 2.23647682251523e-06 75 2342.09090909091 3422 1.55600495497792e-07 75 1.51549577891997 1.56627298249373 1 9.12858952183345 75 3596 3971 3805 3531 509 196 1240 3607 3422 1811 3748 M16514 GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION.html Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production. 39/77 Gene Ontology BP GO:1903556 4.75177008573461e-05 5.11882366863574e-05 2995 3397.72727272727 3422 4.31988429282376e-06 2012 1.88710359610549 -2.13064093916358 -1 8.62569906363662 2992 3404 2612 3496 4301 3918 4400 3422 4017 2801 2012 3749 M11456 GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside phosphate. 171/214 Gene Ontology BP GO:1901293 1.9578137449432e-07 3.91983965370942e-07 4405 3507.45454545455 3423 1.77983083561097e-08 2285 1.61836537465161 1.79525743307661 1 11.0768413354364 4401 3326 3636 3389 2285 4222 3799 3423 2850 2704 4547 3750 M14109 GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR.html An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. 151/183 Gene Ontology BP GO:0072331 1.8507965389736e-06 2.39215452662338e-06 2015 2975.90909090909 3424 1.6825437236338e-07 1393 1.58732581763589 1.61390570421283 1 9.51655347029684 2011 3878 3673 3800 3568 1393 1414 3026 3424 4298 2250 3751 M14870 GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION.html Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic 24/24 Gene Ontology BP GO:0090312 1.87870293034236e-06 2.42485568235312e-06 4045 3536.45454545455 3424 1.70791321333972e-07 2917 1.74242229662907 2.37398080047572 1 10.4463713050644 4041 3140 2917 2967 3573 4450 4123 3376 3141 3749 3424 3752 M12579 GO_MAINTENANCE_OF_LOCATION_IN_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_LOCATION_IN_CELL.html Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. 112/136 Gene Ontology BP GO:0051651 2.2795496215765e-07 4.3363632008158e-07 4335 3485.72727272727 3426 2.0723180525219e-08 2400 1.43821880651039 1.62802269264313 1 9.76317143200353 4332 3023 3652 3161 2400 3804 3426 4321 3187 3166 3871 3753 M14777 GO_POSITIVE_REGULATION_OF_CELL_SIZE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELL_SIZE.html Any process that increases cell size. 18/21 Gene Ontology BP GO:0045793 3.61888215513888e-05 3.92784200323331e-05 2490 3317 3426 3.2899469865298e-06 970 1.43952211453696 1.23402106849399 1 6.73172587929228 2488 4248 3426 3235 4267 2326 970 4436 3812 4001 3278 3754 M14873 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS_WITHIN_A_TISSUE.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. 32/43 Gene Ontology BP GO:0048873 8.43903028204471e-07 1.21757543883268e-06 4495 3586.36363636364 3426 7.67184865381213e-08 2464 1.38683373859523 1.56711773319375 1 8.73922715572012 4491 3426 3096 2464 3191 4170 3130 4294 4188 2891 4109 3755 M11312 GO_REGULATION_OF_FIBROBLAST_MIGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBROBLAST_MIGRATION.html Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. 45/50 Gene Ontology BP GO:0010762 2.11758784230167e-06 2.70541906376433e-06 4310 3572.90909090909 3427 1.92508170960661e-07 2713 1.61223524860094 1.97268431418355 1 9.57467520113245 4306 2713 3398 2988 3611 3777 4466 3427 2908 3112 4596 3756 M11479 GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. 14/22 Gene Ontology BP GO:0051131 2.22300046843702e-05 2.46042368687856e-05 3430 3395.45454545455 3428 2.02092993742618e-06 2462 1.2401359430655 0.812104390416453 1 6.05554585974076 3428 4289 3501 2462 4181 3120 2543 3314 3598 3986 2928 3757 M15102 GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 13/15 Gene Ontology BP GO:0009143 4.17700453791538e-07 6.85317422952054e-07 2800 3370.27272727273 3428 3.79727757361611e-08 2271 2.01135460832199 -1.62366300103673 -1 13.2674381361543 3703 3231 2271 3634 2799 3758 3111 4094 3428 2798 4246 3758 M10359 GO_NATURAL_KILLER_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. 12/15 Gene Ontology BP GO:0001779 1.89059447789451e-07 3.82687561421743e-07 4390 3474.36363636364 3429 1.7187224003317e-08 2049 1.33785307456929 -1.15861325551322 -1 9.15233274699556 4388 2933 2944 3429 2258 4620 4419 3296 2049 3491 4391 3759 M12283 GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CATALYTIC_ACTIVITY.html Any process that activates or increases the activity of an enzyme. 1483/1913 Gene Ontology BP GO:0043085 4.11568618511014e-08 1.97691467186943e-07 3760 2842.09090909091 3429 4.11568626133506e-09 511 1.97040707881257 2.12607815013841 1 14.1431539299908 3760 2097 4359 1465 904 3429 3676 3887 2575 511 4600 3760 M10313 GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MICROTUBULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. 49/55 Gene Ontology BP GO:0031122 1.50016644215114e-07 3.26629578824212e-07 3125 3164.27272727273 3431 1.3637877676787e-08 1746 1.21546840186451 -1.07096568795984 -1 8.39498115116261 3121 3668 3788 3994 2084 3118 3431 2235 3853 3769 1746 3761 M13583 GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA.html Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. 21/25 Gene Ontology BP GO:0090201 2.93621716044446e-07 5.21657825412297e-07 3955 3291 3433 2.66928868393186e-08 735 1.6027470563045 -1.23402956959144 -1 10.7541606069492 3953 3998 3262 2635 2579 3946 4510 3433 735 4269 2881 3762 M11986 GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TELOMERASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). 34/36 Gene Ontology BP GO:0051973 1.23052839178501e-06 1.68252971113007e-06 4470 3367.36363636364 3434 1.11866280005302e-07 1857 1.74630238275842 -1.73311469261604 -1 10.7690253901434 4468 3425 3434 2465 3368 3768 3407 3495 1857 3796 3558 3763 M13233 GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 60/75 Gene Ontology BP GO:0009142 3.24630805530376e-06 3.97471492206976e-06 1560 3153.90909090909 3434 2.9511934959529e-07 1557 1.20477796061668 -0.958704417401451 -1 6.909069928743 1557 3369 3954 3550 3772 2377 2065 3434 2842 4211 3562 3764 M14164 GO_REGULATION_OF_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTON_TRANSPORT.html Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 12/21 Gene Ontology BP GO:0010155 5.17396863856464e-06 6.13675148489453e-06 4100 3338.18181818182 3435 4.70361891524042e-07 1437 1.25202639776439 -1.47854510630458 -1 6.92957685749099 4098 2537 3224 3435 3897 3817 3255 1437 4069 3073 3878 3765 M14359 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS.html Any process that increases the rate, frequency, or extent of a response to cytokine stimulus. 45/59 Gene Ontology BP GO:0060760 1.23117003124333e-06 1.68291250157908e-06 4055 3223.63636363636 3435 1.11924610930419e-07 1648 1.6906867806869 -1.73233055851373 -1 10.4222752343039 4055 2704 2346 1648 3369 4112 3653 3512 3435 2579 4047 3766 M14173 GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. 17/18 Gene Ontology BP GO:0070498 2.53380133935958e-06 3.17527003286833e-06 1410 2530.72727272727 3436 2.30345841601267e-07 795 1.35875119594194 -1.45753881766417 -1 7.94952999243515 1408 3778 3436 3481 3682 1086 870 795 4016 3948 1338 3767 M10776 GO_GLUCOCORTICOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOCORTICOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. 7/24 Gene Ontology BP GO:0008211 1.53902200492683e-06 2.03497283004392e-06 3165 3375.27272727273 3437 1.5390230707928e-07 189 3.02785810378445 3.37566379897 1 18.4851655818292 3161 4312 4261 3437 3528 4292 4169 189 3248 3163 3368 3768 M11499 GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_DEPOLARIZATION.html Any process that activates or increases the frequency, rate or extent of membrane depolarization. 15/17 Gene Ontology BP GO:1904181 1.99555285700365e-05 2.22242878019099e-05 3440 3369.90909090909 3437 1.81415541662223e-06 2143 2.2538312868155 -2.70243100415248 -1 11.2053046589802 3437 3786 2227 4395 4157 2870 2143 4509 4439 2191 2915 3769 M16901 GO_FLUID_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLUID_TRANSPORT.html The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/31 Gene Ontology BP GO:0042044 1.39716501581846e-06 1.87397169115519e-06 3660 2667.54545454545 3437 1.27015082102166e-07 722 3.32993194112432 3.39061152574855 1 20.4692597176768 3658 1937 790 722 3437 3772 3811 4270 1523 905 4518 3770 M16511 GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. 782/916 Gene Ontology BP GO:0006974 9.64369147714467e-07 1.36472312783316e-06 1785 3258.54545454545 3438 9.64369566218256e-08 1361 1.42556249218453 1.43990886650046 1 8.91020617650107 1785 4090 4627 4337 3307 1361 1763 3438 3442 4562 3132 3771 M16642 GO_SYNAPSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYNAPSIS.html The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. 19/41 Gene Ontology BP GO:0007129 0.000510145029286471 0.000525853970152847 1300 2570 3438 4.63875783842483e-05 280 1.41767184949967 1.55224194083693 1 4.90396580127063 1298 3769 3438 4383 4502 1046 280 1668 3815 3618 453 3772 M13136 GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus. 26/29 Gene Ontology BP GO:2001273 6.18563250648502e-06 7.2681181951199e-06 3430 3362.54545454545 3442 5.62331808944924e-07 1815 1.74422888213248 1.84399910915745 1 9.5598988735943 3426 3442 3062 3535 3935 2213 1815 4470 3672 2819 4599 3773 M10662 GO_IRON_COORDINATION_ENTITY_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRON_COORDINATION_ENTITY_TRANSPORT.html The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 10/13 Gene Ontology BP GO:1901678 2.96000560936623e-05 3.2345951386522e-05 1875 2911.09090909091 3444 2.69095039611082e-06 706 1.14826210372653 -1.15449901194514 -1 5.45131580669291 1875 4078 3444 4396 4236 1394 706 1494 4474 3972 1953 3774 M16226 GO_NEGATIVE_REGULATION_OF_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_SILENCING.html Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. 19/26 Gene Ontology BP GO:0060969 2.39775227492652e-05 2.644404203658e-05 3665 3255.27272727273 3444 2.17979855284104e-06 1584 1.56808822634216 -1.31698268140737 -1 7.63383505888809 3664 2860 2964 1584 4195 3634 3444 3241 2310 3616 4296 3775 M10210 GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. 25/40 Gene Ontology BP GO:0045745 3.82234695422255e-06 4.61957931896039e-06 1765 3271.45454545455 3445 3.47486690481875e-07 1763 2.26287344731142 -2.01594737133321 -1 12.9168195791734 4299 3445 1763 3663 3822 4138 3085 1763 3292 2280 4436 3776 M12360 GO_ENAMEL_MINERALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENAMEL_MINERALIZATION.html The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. 10/13 Gene Ontology BP GO:0070166 1.08048152717441e-06 1.50118857746865e-06 4320 3251.36363636364 3445 9.82256416208606e-08 1042 2.24678185491811 1.39703025773464 1 14.0078687658218 4320 2553 1727 3601 3314 4114 3445 4422 1042 2681 4546 3777 M15791 GO_RRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. 27/28 Gene Ontology BP GO:0000154 9.70397742119761e-06 1.11487918372426e-05 760 2616.72727272727 3446 8.82183656793141e-07 65 0.949957577711073 0.884369775601097 1 4.96460384473296 760 3446 3903 4195 4023 634 65 1516 4129 3935 2178 3778 M12286 GO_PEPTIDYL_LYSINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_MODIFICATION.html The modification of peptidyl-lysine. 329/381 Gene Ontology BP GO:0018205 1.41381699769993e-06 1.89145787530126e-06 1585 3272.54545454545 3448 1.28528900571081e-07 1252 1.39722798293788 1.41173376942581 1 8.51710618357029 1585 4631 4185 4342 3448 1969 1252 3044 3877 4591 3074 3779 M12390 GO_REGULATION_OF_FEEDING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEEDING_BEHAVIOR.html Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. 14/30 Gene Ontology BP GO:0060259 2.55260346901224e-06 3.19281288744998e-06 4190 3324.54545454545 3448 2.32055130067024e-07 1238 2.58965382441763 -1.97888412978548 -1 15.2468357744654 4188 3537 2062 3448 3690 4515 4566 1238 3411 2487 3428 3780 M12656 GO_REGULATION_OF_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECRETION.html Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. 668/1075 Gene Ontology BP GO:0051046 3.77337646996089e-15 1.95083563496978e-13 3715 2536 3448 3.7733764699609e-16 36 2.26697366619115 -2.13113110331588 -1 30.9825129800595 3713 1221 4381 36 754 3651 4576 4039 2031 46 3448 3781 M15280 GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. 1586/2144 Gene Ontology BP GO:0071822 4.28260837167014e-08 1.97691467186943e-07 3450 2988.81818181818 3448 4.28260845420344e-09 951 1.92834804616082 2.11789168281712 1 13.8388492213512 3448 1144 4546 3590 951 4079 4438 3402 1751 1290 4238 3782 M15560 GO_EPITHELIAL_STRUCTURE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_STRUCTURE_MAINTENANCE.html A tissue homeostatic process required for the maintenance of epithelial structure. 26/49 Gene Ontology BP GO:0010669 1.7610654468081e-06 2.2908128386911e-06 2805 2945.72727272727 3448 1.60096986955901e-07 1366 3.00475450199647 3.40960972185177 1 18.1764726734671 2804 3448 1366 3927 3546 1872 1439 4068 3476 2822 3635 3783 M12377 GO_POSITIVE_REGULATION_OF_HEART_RATE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HEART_RATE.html Any process that activates or increases the frequency or rate of heart contraction. 25/35 Gene Ontology BP GO:0010460 9.33091520826579e-07 1.32813546846316e-06 4090 3235.18181818182 3449 8.48265378710238e-08 1127 2.97267172346691 -2.90021656283453 -1 18.7407214429639 4087 3449 1127 3306 3238 3984 4116 3360 3533 1253 4134 3784 M10147 GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OR_MAINTENANCE_OF_TRANSMEMBRANE_ELECTROCHEMICAL_GRADIENT.html The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. 9/15 Gene Ontology BP GO:0010248 1.29149688868024e-06 1.74995195778368e-06 4295 3127.63636363636 3450 1.29149763926474e-07 555 2.67035186605459 2.02541439806629 1 16.4780853507309 4292 2564 4228 2309 3450 3873 4301 555 2738 2424 3670 3785 M12310 GO_RESPONSE_TO_EXTERNAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXTERNAL_STIMULUS.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. 1662/2794 Gene Ontology BP GO:0009605 3.69387567373563e-22 5.54438822899738e-20 3760 2594.45454545455 3451 3.69387567373564e-23 15 2.29566659373544 2.52957529677025 1 47.5950766567894 3758 1139 4362 872 687 3451 3744 3934 2318 15 4259 3786 M14205 GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a myeloid leukocyte. 44/91 Gene Ontology BP GO:0002444 3.71088703640348e-07 6.27425776903539e-07 3895 3246.36363636364 3451 3.37353423849432e-08 1536 2.24393628265179 -1.80262502785745 -1 14.9075110112343 3894 3072 1868 3328 2719 4311 4348 3601 1536 3451 3582 3787 M12528 GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENE_EXPRESSION_BY_GENETIC_IMPRINTING.html Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. 16/18 Gene Ontology BP GO:0006349 1.91232583626181e-05 2.13331386145438e-05 2860 3499 3452 1.73849314467854e-06 2340 1.48440523133775 1.09607317882104 1 7.36983532850475 2857 4032 3452 4026 4151 2848 2340 3262 4514 3883 3124 3788 M11050 GO_LYMPHOCYTE_COSTIMULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_COSTIMULATION.html The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. 55/114 Gene Ontology BP GO:0031294 2.60721755087549e-07 4.74438140955168e-07 4015 3349.18181818182 3454 2.37019805441509e-08 2470 1.70517568835159 -1.60116853210842 -1 11.5244979913011 4013 3659 2992 3454 2515 3245 3814 2470 3652 2824 4203 3789 M14044 GO_REGULATION_OF_MITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOPHAGY.html Any process that modulates the frequency, rate or extent of mitochondrion degradation (mitophagy). 56/62 Gene Ontology BP GO:1903146 1.26696969572656e-07 2.93105480790615e-07 4195 3438.27272727273 3454 1.15179069880978e-08 1946 1.0122092947523 0.890130468783605 1 7.02357851480254 4192 2696 3998 3008 1946 3053 4584 2675 3827 4388 3454 3790 M16037 GO_INACTIVATION_OF_MAPK_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INACTIVATION_OF_MAPK_ACTIVITY.html Any process that terminates the activity of the active enzyme MAP kinase. 26/28 Gene Ontology BP GO:0000188 1.57274462189084e-06 2.07543412525754e-06 3220 3173.36363636364 3454 1.42976886020164e-07 1397 1.43123921055063 1.28983643794043 1 8.66491411762044 3219 1893 3009 2809 3493 3454 3609 3805 3995 1397 4224 3791 M16065 GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RAC_PROTEIN_SIGNAL_TRANSDUCTION.html A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. 24/26 Gene Ontology BP GO:0016601 3.37209367216939e-08 1.97691467186943e-07 4025 2988.81818181818 3454 3.06553974895984e-09 538 1.04972568702521 -0.963759560536806 -1 7.48185753267453 4024 1905 3509 3655 538 2871 2704 2628 3454 3750 3839 3792 M10215 GO_RESPONSE_TO_NITROGEN_COMPOUND http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NITROGEN_COMPOUND.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. 868/1225 Gene Ontology BP GO:1901698 2.58798670380196e-08 1.97691467186943e-07 3685 2407.27272727273 3455 2.5879867339415e-09 127 2.12847957047882 -1.90364089468576 -1 15.2868369984702 3684 1204 4232 127 370 3506 3560 3455 1732 396 4214 3793 M13321 GO_REGULATION_OF_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 19/23 Gene Ontology BP GO:0044030 1.44073917621618e-06 1.92415596639893e-06 2790 3370.45454545455 3455 1.30976374520945e-07 2160 0.810496930652867 0.704553057684934 1 4.88655624197337 2789 2469 3798 3218 3455 2421 2160 4434 3956 4207 4168 3794 M10601 GO_REGULATION_OF_PHOSPHATASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PHOSPHATASE_ACTIVITY.html Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 137/177 Gene Ontology BP GO:0010921 9.9649952867321e-08 2.57738316115422e-07 4230 3232.54545454545 3456 9.05908703463716e-09 1733 1.73425753712882 -1.47787811541371 -1 12.218970165154 4226 2203 3192 2827 1733 3624 4087 4021 2625 3564 3456 3795 M12148 GO_POLYSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 23/33 Gene Ontology BP GO:0000272 2.25163401116563e-05 2.49033825860558e-05 1485 2776 3456 2.04696096026779e-06 632 1.18916999949223 1.1669348264104 1 5.79529693910031 1485 3456 3627 3483 4184 1650 632 2135 3623 3895 2366 3796 M12731 GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. 178/268 Gene Ontology BP GO:0006109 1.20638155187007e-07 2.86246474291252e-07 4130 3316.63636363636 3456 1.09671056183877e-08 1903 1.86071682900786 -1.29405851136037 -1 13.0267114947364 4128 3604 2739 3717 1903 3934 3092 3142 2664 3456 4104 3797 M13378 GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MACROPHAGE_CYTOKINE_PRODUCTION.html Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. 16/24 Gene Ontology BP GO:0010935 1.32629651359036e-05 1.50481777072322e-05 3460 3294.72727272727 3456 1.20573137217838e-06 1637 2.31908593536125 -1.66708272051043 -1 11.9568428958687 3456 2890 1774 1637 4079 3910 4649 3770 3281 2400 4396 3798 M11438 GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. 81/164 Gene Ontology BP GO:0030518 2.10620314674762e-06 2.69235253896063e-06 2410 3244.81818181818 3460 1.91473196650513e-07 2006 1.55149102886904 1.58823368114099 1 9.21318945266653 2410 3639 3737 3460 3608 2895 2750 4383 2006 4094 2711 3799 M16526 GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CAMP_MEDIATED_SIGNALING.html Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. 8/17 Gene Ontology BP GO:0043950 0.000457530829445621 0.000472876710220007 3140 3186.45454545455 3460 4.57625057258067e-05 844 2.75813024642195 -3.52216562773355 -1 9.7850504455355 3139 3840 4631 2760 4548 4080 3460 1217 844 3804 2728 3800 M10195 GO_NUCLEOSOME_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSOME_DISASSEMBLY.html The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. 22/41 Gene Ontology BP GO:0006337 4.57251651699526e-06 5.45676310684251e-06 3585 3397 3461 4.15684183692467e-07 1984 1.38638428071018 -1.67025227271761 -1 7.76165559342178 3585 3461 3428 3193 3871 3477 1984 3207 3888 3836 3437 3801 M10543 GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DNA_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-DNA complex into its constituent components. 22/41 Gene Ontology BP GO:0032986 4.57251651699526e-06 5.45676310684251e-06 3590 3396.90909090909 3462 4.15684183692467e-07 1985 1.38638428071018 -1.67025227271761 -1 7.76165559342178 3586 3462 3429 3194 3872 3478 1985 3196 3889 3837 3438 3802 M15016 GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. 40/45 Gene Ontology BP GO:0002753 7.81046495043921e-06 9.07191548037785e-06 935 2733 3462 7.10044789034389e-07 748 1.40108173793948 -1.40096043851316 -1 7.51132289728393 933 4171 3802 3522 3979 1695 1557 748 3462 4147 2047 3803 M11576 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process. 9/16 Gene Ontology BP GO:1904406 1.28361961412378e-06 1.74154777010421e-06 3835 3297.90909090909 3463 1.28362035558008e-07 1102 1.9871321102013 2.14316901711763 1 12.2376513440483 3833 1102 4312 2373 3446 4542 4450 3289 3463 1259 4208 3804 M11768 GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 129/154 Gene Ontology BP GO:0042177 4.41982872778648e-08 1.97691467186943e-07 3670 3161.45454545455 3464 4.01802619689219e-09 856 1.60530079098281 1.66384965323284 1 11.5015438991457 3669 3017 3579 3190 856 3464 3365 3712 2247 3669 4008 3805 M12164 GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NITRIC_OXIDE_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. 9/16 Gene Ontology BP GO:0045019 1.28361961412378e-06 1.74154777010421e-06 3835 3307.63636363636 3464 1.28362035558008e-07 1103 1.9871321102013 2.14316901711763 1 12.2376513440483 3834 1103 4350 2374 3447 4543 4451 3347 3464 1262 4209 3806 M10384 GO_INTERMEDIATE_FILAMENT_BASED_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERMEDIATE_FILAMENT_BASED_PROCESS.html Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. 51/72 Gene Ontology BP GO:0045103 1.02311246510088e-06 1.43045141229399e-06 3465 3051.81818181818 3465 9.30102673546173e-08 895 2.8829003117678 3.33152946529226 1 18.0710768432736 3465 2694 968 1844 3291 4505 3672 3762 4024 895 4450 3807 M14246 GO_OXALATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXALATE_TRANSPORT.html The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. 6/12 Gene Ontology BP GO:0019532 0.000109270945019875 0.000115213620479827 3045 3560.63636363636 3466 1.09276318454488e-05 2168 1.30388503144383 -1.50753396222864 -1 5.42912960941455 3041 3284 4483 3901 4404 3033 3466 3648 4603 2168 3136 3808 M14580 GO_REGULATION_OF_MYOBLAST_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MYOBLAST_FUSION.html Any process that modulates the frequency, rate or extent of myoblast fusion. 15/24 Gene Ontology BP GO:1901739 3.08289368163589e-06 3.78788072369998e-06 3470 3343.36363636364 3467 2.80263454704589e-07 2468 1.98917232040835 -2.67525599377325 -1 11.5258785558481 3467 3518 2468 3858 3758 4053 3761 3216 2605 3123 2950 3809 M15127 GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that activates or increases the frequency, rate or extent of DNA recombination. 16/22 Gene Ontology BP GO:0045911 3.82347630111389e-06 4.61974428176654e-06 4015 3223.72727272727 3469 3.47589358737899e-07 1327 1.45364652393577 -1.31923558062618 -1 8.25716222013977 4012 2884 3233 2153 3823 3636 3469 2951 1327 3630 4343 3810 M10992 GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. 15/16 Gene Ontology BP GO:0045910 4.08754706305668e-06 4.92092017707704e-06 1150 2782 3470 3.71595877967321e-07 1147 1.19291983975842 1.27361182783739 1 6.72055639165338 1147 3788 3653 4151 3839 1410 1933 2069 3993 3470 1149 3811 M16177 GO_LYMPHOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_APOPTOTIC_PROCESS.html Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. 20/24 Gene Ontology BP GO:0070227 8.34829106352378e-07 1.20710373892406e-06 4105 3463.81818181818 3470 7.58935839221173e-08 2640 1.13582301223661 1.0030694654072 1 7.14159419336464 4104 3470 3681 2640 3185 3988 3472 3718 3378 3060 3406 3812 M11188 GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 15/17 Gene Ontology BP GO:0009129 3.1642207619746e-08 1.97691467186943e-07 3300 3000.90909090909 3471 2.87656437044092e-09 466 0.975231764057403 -0.765310094152471 -1 6.94288052595554 3298 1001 3557 4379 466 2720 1738 4507 3941 3471 3932 3813 M13506 GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3. 23/28 Gene Ontology BP GO:0051570 1.73513713974919e-06 2.261510675421e-06 3695 3435.54545454545 3471 1.57739864386464e-07 2386 1.64355833170335 -2.13386362080452 -1 9.9009564789296 3694 3471 3200 3534 3540 3293 4631 2672 3313 4057 2386 3814 M16321 GO_GLUCOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. 33/52 Gene Ontology BP GO:0006007 6.17183979374949e-08 2.12251075833824e-07 4160 3239.81818181818 3471 5.61076360626653e-09 1246 1.63694474159938 -1.26768346933168 -1 11.6759715339235 4160 3107 2912 3700 1246 4318 4237 2873 1889 3725 3471 3815 M15498 GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 34/37 Gene Ontology BP GO:1900101 4.99826981289764e-07 7.89709658384132e-07 3255 3601.72727272727 3474 4.5438826804321e-08 2911 0.936179282262574 0.754172766187692 1 6.05262142089708 3253 3696 3874 3811 2911 3455 3320 3474 4546 4066 3213 3816 M14501 GO_CELLULAR_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. 145/207 Gene Ontology BP GO:0009267 2.00114832546044e-07 3.97760141854629e-07 4315 3292.90909090909 3475 1.81922591589772e-08 2006 2.00924221454067 -1.8558417774196 -1 13.7657232619837 4311 3015 2287 2006 2298 3806 3096 4451 3653 3824 3475 3817 M15194 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator. 26/29 Gene Ontology BP GO:1902253 6.38420164909363e-06 7.48442687660183e-06 2135 3242.36363636364 3475 5.80383652322407e-07 2132 1.46846277134257 1.6442733839368 1 8.01039351532605 2134 3725 3314 4003 3941 2277 2132 3475 4054 3674 2937 3818 M15218 GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION.html The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. 15/17 Gene Ontology BP GO:0034314 1.47278174484768e-07 3.23095401168139e-07 4595 3037.45454545455 3475 1.33889258494773e-08 965 1.24883462990667 -1.13685169422646 -1 8.63490716808008 4595 965 3303 2546 2068 4153 3582 3825 1204 3475 3696 3819 M12606 GO_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_REPAIR.html The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. 499/574 Gene Ontology BP GO:0006281 1.51069578488547e-06 2.00378206587004e-06 1550 3198.72727272727 3476 1.37336074750082e-07 1369 1.2658924350236 1.33432587174028 1 7.67166270976533 1547 4093 4204 4339 3476 1369 1622 3138 3777 4561 3060 3820 M12559 GO_ATRIAL_SEPTUM_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_MORPHOGENESIS.html The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. 13/20 Gene Ontology BP GO:0060413 0.000516722386673405 0.00053251589483751 3505 3333.72727272727 3478 4.69857991956977e-05 1955 1.37526537631214 0.820455359030224 1 4.74577669726855 3502 3816 3478 2048 4503 4298 2949 1955 2845 4316 2961 3821 M12941 GO_CHROMATIN_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_DISASSEMBLY.html The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. 22/41 Gene Ontology BP GO:0031498 4.57251651699526e-06 5.45676310684251e-06 3590 3452.72727272727 3479 4.15684183692467e-07 1986 1.38638428071018 -1.67025227271761 -1 7.76165559342178 3587 3463 3430 3195 3873 3479 1986 3798 3890 3840 3439 3822 M14249 GO_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TOR_SIGNALING.html Any process that modulates the frequency, rate or extent of TOR signaling. 83/108 Gene Ontology BP GO:0032006 9.66889410808816e-08 2.54464730118406e-07 2720 3051.72727272727 3479 8.78990412093768e-09 1549 1.52066489427668 -1.050022078294 -1 10.7092527946772 2720 3893 3801 3566 1704 2486 3479 3773 2390 4208 1549 3823 M13937 GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY.html The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. 26/66 Gene Ontology BP GO:0002228 1.56662261523449e-06 2.06852866875315e-06 3745 3414.09090909091 3481 1.42420339166312e-07 2787 1.88070164607227 -1.36758359281112 -1 11.424474687208 3744 3978 2918 3457 3491 3481 3203 2787 3906 2820 3770 3824 M15868 GO_DNA_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. 17/17 Gene Ontology BP GO:0006266 2.82657586980409e-06 3.50254527888108e-06 1910 2633.45454545455 3483 2.56961772855972e-07 823 1.0635545024651 1.03104673339527 1 6.14897593544093 1907 3501 3619 3944 3728 1512 1092 823 3483 3950 1409 3825 M12852 GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. 86/96 Gene Ontology BP GO:0070301 2.95259518879412e-07 5.23568041671458e-07 4095 3421.27272727273 3484 2.68417780459879e-08 2049 1.5588244115141 -1.65631430587153 -1 10.4536771820451 4093 2656 3484 2049 2584 3909 3014 4428 3190 3690 4537 3826 M13097 GO_PROTEIN_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_STABILIZATION.html Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. 150/182 Gene Ontology BP GO:0050821 8.83936825708455e-07 1.26970770846354e-06 3530 3539.63636363636 3486 8.03579255331964e-08 2916 1.7552079265813 1.69238762395543 1 11.0561127088618 3529 3877 3486 3205 3208 3393 3446 2916 3642 4096 4138 3827 M10962 GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATPASE_ACTIVITY.html Any process that stops or reduces the rate of ATP hydrolysis by an ATPase. 18/28 Gene Ontology BP GO:0032780 1.63205212205579e-06 2.1447844581677e-06 3810 3134.09090909091 3487 1.48368484798332e-07 1835 2.65056572766616 -2.48020313394101 -1 16.1023987023456 3810 3502 2165 3648 3507 3373 1835 3487 3663 2756 2729 3828 M11488 GO_MICROTUBULE_NUCLEATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_NUCLEATION.html The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). 21/24 Gene Ontology BP GO:0007020 7.51508249898185e-05 8.00908815111373e-05 2725 3506.72727272727 3488 6.83212656587607e-06 1984 0.717834511512661 -0.807222669411272 -1 3.06043584629409 2721 3488 3966 4238 4353 2849 3173 2799 4547 4456 1984 3829 M12152 GO_INNER_CELL_MASS_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_CELL_MASS_CELL_PROLIFERATION.html The proliferation of cells in the inner cell mass. 10/11 Gene Ontology BP GO:0001833 7.23376278885215e-05 7.72342777800116e-05 3910 3290 3488 6.57636422843169e-06 1783 1.14683541898209 -0.763226864626152 -1 4.97656341623658 3909 3555 3488 2443 4345 3714 1783 2499 3213 3202 4039 3830 M15163 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS_VIA_SOMATIC_MUTATION.html The process in which immune receptor genes are diversified through somatic mutation. 11/14 Gene Ontology BP GO:0002566 5.48816747936661e-05 5.89075969584609e-05 3085 3503.18181818182 3488 4.98936763014425e-06 2261 1.22315097195145 1.4776363296964 1 5.47054281571247 3084 3554 3481 3947 4319 3488 4202 2261 3860 3346 2993 3831 M11910 GO_FOREBRAIN_REGIONALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOREBRAIN_REGIONALIZATION.html The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. 12/33 Gene Ontology BP GO:0021871 1.66734047783256e-05 1.87033154372105e-05 3550 3041.27272727273 3490 1.51577555858235e-06 1017 1.67998273018823 -2.02407788548792 -1 8.45934060114851 3548 3823 3221 2194 4125 3490 2528 2433 1017 3494 3581 3832 M16092 GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SERINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. 35/47 Gene Ontology BP GO:0009069 1.55929209764894e-06 2.05943404211198e-06 3900 3054.45454545455 3490 1.41753927529831e-07 623 1.88449540282448 1.27182568594623 1 11.4516403199997 3898 1817 2404 1531 3490 4188 4432 4339 623 2627 4250 3833 M13210 GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CERAMIDE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process. 17/17 Gene Ontology BP GO:2000303 2.70241294190389e-05 2.96704280761652e-05 4095 3349.72727272727 3493 2.45676921644694e-06 2016 1.80660166564398 -1.33047423884568 -1 8.71469997993879 4091 3493 3075 2995 4217 3888 3974 2177 2016 3697 3224 3834 M10803 GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. 126/152 Gene Ontology BP GO:0034250 4.68494546530962e-07 7.50817487039555e-07 3210 3451.36363636364 3495 4.25904223907158e-08 1601 1.81086215745883 1.97569250493972 1 11.8561870693793 3210 3882 3293 3530 2868 3495 3487 4121 1601 4220 4258 3835 M11769 GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. 300/373 Gene Ontology BP GO:0006520 1.63852465363029e-07 3.46076042366852e-07 4005 2918.81818181818 3495 1.48956797787726e-08 1078 1.97305746959434 -2.024234262393 -1 13.6444982747467 4001 1375 2554 2059 2156 3548 3495 4042 1078 3523 4276 3836 M13329 GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. 69/119 Gene Ontology BP GO:0002762 1.02325672064303e-05 1.17300160659079e-05 3010 3486.54545454545 3496 9.30237709101659e-07 2587 1.82202691803388 -1.81473310563973 -1 9.58257835065814 3009 4399 2846 3806 4034 3496 4147 2587 4076 3047 2905 3837 M10815 GO_PROTEIN_LOCALIZATION_TO_CILIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CILIUM.html A process in which a protein is transported to, or maintained in, a location within a cilium. 29/32 Gene Ontology BP GO:0061512 6.31678379631142e-07 9.54285552085618e-07 4025 3262.72727272727 3497 5.74253237275309e-08 699 1.39357852098737 -1.18972129144853 -1 8.94142881498811 4021 699 3503 3652 3041 4455 3497 3909 2537 3145 3431 3838 M16113 GO_MIDGUT_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MIDGUT_DEVELOPMENT.html The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. 18/25 Gene Ontology BP GO:0007494 2.95402536922419e-05 3.22881842682644e-05 3675 3287.54545454545 3497 2.68551366801342e-06 1774 2.32216972325706 -2.50067168193277 -1 11.1419515672753 3671 3497 2088 3484 4235 3766 3181 1774 3959 2328 4180 3839 M10860 GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. 35/40 Gene Ontology BP GO:0035872 1.52368704280762e-05 1.71830242612308e-05 1285 2821.54545454545 3500 1.38517963248922e-06 1026 1.45452160238128 -1.39442314070964 -1 7.36667858032083 1283 4180 3753 3500 4103 1905 1375 1026 3514 3994 2404 3840 M13855 GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POST_TRANSLATIONAL_PROTEIN_MODIFICATION.html The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. 28/34 Gene Ontology BP GO:0043687 9.80766512888117e-08 2.56809599576163e-07 3510 3413.45454545455 3501 8.91605960555437e-09 1712 1.74118298518254 -0.998120274842162 -1 12.2711620670782 3508 3974 3338 4393 1712 2907 3323 3501 2972 3806 4114 3841 M11708 GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 13/16 Gene Ontology BP GO:0032239 0.00957357801622265 0.00970498006742571 2010 3538.36363636364 3502 0.000874135839945605 2009 1.59711247655747 1.84023292848057 1 3.35662717050081 2009 4570 3502 4412 4575 3002 2506 4050 3123 3925 3248 3842 M13029 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_ABSENCE_OF_LIGAND.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. 18/19 Gene Ontology BP GO:2001241 8.38566833851503e-05 8.91240629947703e-05 3100 3725.09090909091 3502 7.62362544487396e-06 3099 1.18272329044979 1.5844557444905 1 5.05645916944414 3099 4260 3461 4041 4364 3124 3502 3832 4468 3483 3342 3843 M13735 GO_POSITIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_REPAIR.html Any process that activates or increases the frequency, rate or extent of DNA repair. 46/61 Gene Ontology BP GO:0045739 1.44902309045045e-07 3.19401131586796e-07 3505 3306.18181818182 3502 1.31729380535446e-08 2054 1.5974534350998 -1.67588553324492 -1 11.0855694103885 4207 3384 3050 3502 2054 4578 3505 3943 2269 3773 2103 3844 M13737 GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CEREBRAL_CORTEX_GABAERGIC_INTERNEURON_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. 4/18 Gene Ontology BP GO:0021892 1.46902519310151e-06 1.95743820833371e-06 4360 2791.36363636364 3502 1.46902616421817e-07 14 3.1447933625294 -1.18374603052964 -1 19.260684677997 4356 2089 4447 1380 3502 4179 4598 799 14 1357 3984 3845 M11330 GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process. 18/25 Gene Ontology BP GO:1902931 3.58261722389754e-06 4.35587090221983e-06 4030 3343.45454545455 3504 3.25693005278927e-07 1869 2.48484039927764 -1.38188493834635 -1 14.2633912906332 4026 3504 1869 2529 3803 4116 4089 3105 2004 3480 4253 3846 M10596 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY_INVOLVED_IN_APOPTOTIC_PROCESS.html Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. 28/29 Gene Ontology BP GO:1902108 1.13299682433313e-07 2.75723547260568e-07 3585 3450.09090909091 3505 1.02999716607483e-08 1848 1.38393193806529 -1.37626848792001 -1 9.68409848810678 3583 2784 3460 4182 1848 3299 3482 3505 3987 3977 3844 3847 M11123 GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_BIOSYNTHETIC_PROCESS.html A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism. 1225/1598 Gene Ontology BP GO:0044711 3.40902433960126e-08 1.97691467186943e-07 3505 3161.54545454545 3505 3.40902439189777e-09 662 1.85119715484477 -1.72155686402316 -1 13.2806485680551 3505 2590 4278 3852 662 3352 3613 4000 1948 3115 3862 3848 M12663 GO_LYMPHOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOCYTE_MEDIATED_IMMUNITY.html Any process involved in the carrying out of an immune response by a lymphocyte. 106/369 Gene Ontology BP GO:0002449 1.56300206141375e-07 3.35145096394387e-07 4560 3209.54545454545 3505 1.420911065871e-08 1578 2.05085040915764 -2.08022064359688 -1 14.2177784364143 4560 3627 1929 3900 2117 3684 3375 4200 3505 1578 2830 3849 M15857 GO_2_OXOGLUTARATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_2_OXOGLUTARATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. 19/25 Gene Ontology BP GO:0006103 1.62590467935982e-06 2.13770400482093e-06 3230 3278.54545454545 3505 1.47809625543817e-07 2003 1.18386317721971 0.972527694973415 1 7.13131516387723 3226 2461 3507 3675 3505 2931 3059 4257 2003 3615 3825 3850 M16194 GO_REGULATION_OF_TISSUE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TISSUE_REMODELING.html Any process that modulates the frequency, rate, or extent of tissue remodeling. 63/85 Gene Ontology BP GO:0034103 6.1226239367063e-08 2.11467735746825e-07 4285 2707.09090909091 3505 5.5660219155451e-09 509 2.65420423473184 -2.4768308037081 -1 19.0067456541531 4282 1713 509 1563 1237 3505 3528 4605 3591 615 4630 3851 M12370 GO_INTRACELLULAR_SIGNAL_TRANSDUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_SIGNAL_TRANSDUCTION.html The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. 1551/2025 Gene Ontology BP GO:0035556 3.89655539352814e-08 1.97691467186943e-07 3510 2716.09090909091 3506 3.89655546185227e-09 813 1.93155585200912 2.10845854763027 1 13.8620582768738 3506 1145 4365 1292 813 3623 3716 4110 2150 832 4325 3852 M16244 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_GOLGI.html The directed movement of a protein to a specific location in the Golgi apparatus. 18/19 Gene Ontology BP GO:0072600 2.20004407592137e-05 2.43675436449943e-05 1140 2793.18181818182 3506 2.00006007010083e-06 302 0.910284824135715 -0.870907172446283 -1 4.41893553364118 1139 3506 3806 4413 4179 1218 302 1642 4428 4168 1924 3853 M15673 GO_AXONEME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_AXONEME_ASSEMBLY.html The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. 53/98 Gene Ontology BP GO:0035082 2.75532312302373e-07 4.95875326023698e-07 4120 3547.18181818182 3507 2.50483951645987e-08 2420 1.91289743303313 -2.00174934294838 -1 12.9025481105358 4118 3912 2420 4399 2542 4459 4497 3507 2951 3093 3121 3854 M11006 GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_RIBONUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar. 14/18 Gene Ontology BP GO:0009208 4.89824545275949e-06 5.8215928714406e-06 2715 3384 3508 4.45296032601413e-07 2468 0.76290056297808 -0.680554659149379 -1 4.19708577777532 2712 2517 3775 3970 3887 2468 2671 3468 4266 3982 3508 3855 M10822 GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_HOMODIMERIZATION_ACTIVITY.html Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer. 44/53 Gene Ontology BP GO:0043496 1.39847646086983e-05 1.5820838736755e-05 2665 3440.27272727273 3509 1.27135031878173e-06 2243 1.53582055485476 -1.02506126483772 -1 7.84420769501209 2661 3929 3131 3737 4089 2243 3005 4516 3509 3960 3063 3856 M13939 GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_MACROPHAGE_COLONY_STIMULATING_FACTOR_PRODUCTION.html Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. 5/18 Gene Ontology BP GO:0032645 7.73000476554929e-05 8.23059775151049e-05 3985 3417.63636363636 3509 7.73027366709545e-06 1450 1.88036874010416 -1.24062312612154 -1 8.17593447224857 3983 3289 4461 3509 4366 3170 1450 1769 4621 2620 4356 3857 M15129 GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 4/21 Gene Ontology BP GO:0033139 1.48444772094459e-06 1.97516020747932e-06 4615 3244.18181818182 3509 1.48444871255879e-07 1358 3.2655639354524 -3.09917580415141 -1 19.9909076088255 4614 2965 4536 1567 3509 3892 4555 1892 3768 1358 3030 3858 M10258 GO_EMBRYONIC_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EMBRYONIC_HEMOPOIESIS.html The stages of blood cell formation that take place within the embryo. 21/26 Gene Ontology BP GO:0035162 1.02472945091441e-05 1.17440052588787e-05 3050 3635.72727272727 3510 9.31576567266386e-07 2991 1.79051516263394 1.86195448851426 1 9.41389244051235 3046 4494 2991 3510 4035 3532 3471 4177 4218 3505 3014 3859 M12516 GO_LEUKOCYTE_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEUKOCYTE_PROLIFERATION.html The expansion of a leukocyte population by cell division. 71/127 Gene Ontology BP GO:0070661 7.64485176739908e-08 2.29998364753442e-07 4045 3040.63636363636 3510 6.94986548459324e-09 1430 2.28213802549989 -2.29859166876275 -1 16.2366768617597 4042 3362 1523 1430 1454 4319 4362 3613 3711 2121 3510 3860 M15888 GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PEPTIDYL_SERINE_PHOSPHORYLATION_OF_STAT_PROTEIN.html Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. 4/21 Gene Ontology BP GO:0033141 1.48444772094459e-06 1.97516020747932e-06 4615 3248.45454545455 3510 1.48444871255879e-07 1359 3.2655639354524 -3.09917580415141 -1 19.9909076088255 4615 2966 4579 1568 3510 3893 4556 1887 3769 1359 3031 3861 M10830 GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_DNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mitochondrial DNA. 18/18 Gene Ontology BP GO:0032042 2.43356994037437e-06 3.06286203206977e-06 3515 3635.54545454545 3511 2.21233875665101e-07 3178 1.18810445180816 -1.17314370342792 -1 6.95700876628229 3511 3189 3474 3482 3667 3949 4207 3768 4088 3478 3178 3862 M16716 GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar. 63/88 Gene Ontology BP GO:0009185 4.56134316232185e-08 1.97760774550163e-07 4615 3502.90909090909 3511 4.14667568808537e-09 915 1.55330547855258 -1.21857173781913 -1 11.1250932146986 4612 3364 3344 4139 915 3899 4483 2807 3511 3026 4432 3863 M12368 GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. 48/79 Gene Ontology BP GO:1903018 1.16741660855419e-07 2.8188840060211e-07 3890 3483.72727272727 3514 1.06128788227495e-08 1867 1.37161593517965 -1.18711166762145 -1 9.58269470929324 3887 2705 3514 4531 1867 3294 3604 4651 4375 3140 2753 3864 M14828 GO_MEMBRANE_HYPERPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_HYPERPOLARIZATION.html The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. 8/21 Gene Ontology BP GO:0060081 1.50794113474656e-06 2.0006986313019e-06 4520 3333.18181818182 3518 1.50794215799645e-07 831 1.73371523566693 1.74255414774905 1 10.5498476506422 3525 2956 4518 2891 3518 2693 831 3687 4191 3336 4519 3865 M12683 GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INSULIN_RECEPTOR_SIGNALING_PATHWAY.html Any process that increases the frequency, rate or extent of insulin receptor signaling. 16/20 Gene Ontology BP GO:0046628 1.08011100917777e-05 1.23452628978241e-05 2750 3126.63636363636 3520 9.81923920111244e-07 1299 2.28123661223409 2.97456012116305 1 11.9715419148091 2750 3520 2959 2041 4045 2263 1299 4393 3700 3627 3796 3866 M10273 GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CYTOSKELETON.html A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. 38/38 Gene Ontology BP GO:0044380 4.69173443481709e-08 1.98252330758246e-07 3815 3388.45454545455 3521 4.26521321352121e-09 948 1.22719378339704 -0.954888806640987 -1 8.76424176557155 3815 3405 3639 3713 948 3841 3452 3379 3521 3442 4118 3867 M11443 GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY.html Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. 31/34 Gene Ontology BP GO:1901889 1.00187467331697e-05 1.14962339209466e-05 4285 3611 3523 9.10799305326419e-07 2737 1.71182593396513 1.40423090226495 1 9.01231068169445 4285 4189 3290 3503 4030 3050 2737 3523 3004 3590 4520 3868 M11589 GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS.html Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. 859/1065 Gene Ontology BP GO:0044087 3.51445847140128e-08 1.97691467186943e-07 4060 2711.18181818182 3524 3.51445852698266e-09 522 1.97962853389908 2.23922935961635 1 14.2098728254673 4056 1203 4314 522 695 3985 4041 3524 1632 1600 4251 3869 M14965 GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_ENDOTHELIAL_BARRIER.html The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. 38/40 Gene Ontology BP GO:0061028 1.73255064376496e-07 3.60278591263368e-07 4105 3258.63636363636 3527 1.57504616382484e-08 2192 2.00648217562033 -1.93268889951826 -1 13.8397358123741 4101 3941 2834 2527 2192 3739 3747 2694 3527 2947 3596 3870 M14822 GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NONMOTILE_PRIMARY_CILIUM_ASSEMBLY.html The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules. 24/26 Gene Ontology BP GO:0035058 2.60550212902371e-06 3.25198535577986e-06 2520 3015.09090909091 3529 2.36864110434081e-07 1093 1.28922336600527 1.69015494365171 1 7.52253656943871 2516 3990 3657 3529 3699 2105 1093 2785 3647 3954 2191 3871 M16815 GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation. 48/91 Gene Ontology BP GO:0045671 1.50030957986316e-05 1.69399186486369e-05 3225 3345.54545454545 3529 1.36392710132323e-06 2167 2.00061659904263 -1.87209721389358 -1 10.1882954486009 3225 3671 2167 2974 4096 3529 3868 4125 3710 2632 2804 3872 M10908 GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PREASSEMBLY_OF_GPI_ANCHOR_IN_ER_MEMBRANE.html The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. 15/15 Gene Ontology BP GO:0016254 0.000194583196227594 0.000202776172910861 1655 2813.81818181818 3531 1.76909462400822e-05 1367 0.932343780982409 -0.951738706010725 -1 3.60283639493471 1651 3531 3739 3694 4453 1367 1435 1409 3958 4036 1679 3873 M11419 GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. 27/39 Gene Ontology BP GO:0043508 0.000132339054923981 0.000138938091733141 4010 3550.18181818182 3531 1.20315469393918e-05 2366 1.80048994154865 -1.1355098210333 -1 7.38196140293877 4010 3441 2587 3531 4419 3224 3867 2366 3631 3527 4449 3874 M15178 GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_ALPHA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. 33/54 Gene Ontology BP GO:0032727 1.5589179338307e-05 1.75675590848008e-05 3785 3469.18181818182 3532 1.41720816401648e-06 2491 1.72065421648145 -1.59698231438843 -1 8.71739805703167 3784 3429 2657 3532 4106 3779 2491 3166 3658 3273 4286 3875 M11360 GO_PROTEIN_DEALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEALKYLATION.html The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 28/32 Gene Ontology BP GO:0008214 1.71493016130694e-06 2.23893659948406e-06 2395 3652.81818181818 3533 1.55902863465452e-07 2392 0.788539630074609 0.896652824496188 1 4.69511162468604 2392 4202 4023 4580 3533 3346 3078 2730 4495 4407 3395 3876 M13051 GO_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that modulates the frequency, rate or extent of a response to a food stimulus. 13/22 Gene Ontology BP GO:0032095 3.49058399196041e-06 4.24841415500701e-06 3600 3532.09090909091 3533 3.17326320930437e-07 2298 3.07369231582688 3.49099504897098 1 17.7062852401614 3598 4562 2298 4543 3798 3533 3207 4216 3013 2794 3291 3877 M14667 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_17_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. 7/14 Gene Ontology BP GO:0032740 0.0118789612641364 0.012031520845021 3390 3809 3533 0.00119429425187788 3164 2.2549321098566 -1.21359056747836 -1 4.55862222320199 3390 4313 4509 3533 4581 3480 3355 3722 3412 3164 4440 3878 M10884 GO_SNORNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNORNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. 10/12 Gene Ontology BP GO:0016074 4.44904348120019e-05 4.80199473858142e-05 3255 3659.27272727273 3534 4.0446667785635e-06 2092 0.906517339152825 -0.725463056951767 -1 4.11194908368239 3251 4582 3534 4176 4293 3221 2092 3133 4472 3973 3525 3879 M10938 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. 85/136 Gene Ontology BP GO:0042993 1.40158400153996e-06 1.87833247671816e-06 3535 3430.90909090909 3534 1.27416808587908e-07 2880 1.79998241615561 -1.43515819942728 -1 11.0106586784901 3534 3636 2896 3804 3440 2955 4471 2894 2880 3545 3685 3880 M13741 GO_PROTEIN_DEMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_DEMETHYLATION.html The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 28/32 Gene Ontology BP GO:0006482 1.71493016130694e-06 2.23893659948406e-06 2395 3667.27272727273 3534 1.55902863465452e-07 2393 0.788539630074609 0.896652824496188 1 4.69511162468604 2393 4203 4024 4581 3534 3347 3079 2879 4496 4408 3396 3881 M10361 GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INFLAMMATORY_RESPONSE_TO_ANTIGENIC_STIMULUS.html Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus. 9/20 Gene Ontology BP GO:0002861 2.39357865600832e-05 2.6404270949281e-05 3325 3328.09090909091 3535 2.39360443788368e-06 1815 1.76424643969928 -2.29984207562986 -1 8.60417338485271 3321 3567 4236 3709 4214 3535 2428 2507 3903 1815 3374 3882 M11686 GO_REGULATION_OF_PROTEIN_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_GLYCOSYLATION.html Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. 14/16 Gene Ontology BP GO:0060049 3.21495004086163e-06 3.93869471830678e-06 3005 3210.72727272727 3535 2.9226861263721e-07 1510 0.995743915162678 -1.12469278881444 -1 5.69494306044881 3005 2023 3535 3673 3770 3422 3647 2886 4137 3710 1510 3883 M14492 GO_TRACHEA_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRACHEA_MORPHOGENESIS.html The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. 15/21 Gene Ontology BP GO:0060439 1.71794050172295e-06 2.24223763100053e-06 4250 2976.81818181818 3535 1.56176531203028e-07 73 2.64782993955032 -1.53203905732083 -1 16.0305155070197 4247 3212 2649 866 3535 4613 4242 1519 73 3821 3968 3884 M12983 GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHASIC_SMOOTH_MUSCLE_CONTRACTION.html A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. 9/20 Gene Ontology BP GO:0014821 8.15697059237203e-06 9.46021539539059e-06 3540 3442.81818181818 3536 8.15700053380287e-07 1263 2.70903847139051 -2.09031539935977 -1 14.575757995723 3536 2563 4398 2376 4004 3371 4289 3515 4215 1263 4341 3885 M14208 GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNOGLOBULIN_PRODUCTION_INVOLVED_IN_IMMUNOGLOBULIN_MEDIATED_IMMUNE_RESPONSE.html The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. 16/24 Gene Ontology BP GO:0002381 1.5628126802369e-05 1.7598662635872e-05 1040 2896.09090909091 3536 1.42074889280943e-06 925 1.17171852235308 1.08519993642933 1 5.89925722843605 1040 4040 3663 3536 4108 1504 925 2344 4171 3628 2898 3886 M14303 GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein-RNA complex into its constituent components. 17/17 Gene Ontology BP GO:0032988 0.00150976039291753 0.00154665678296902 2650 3353.27272727273 3536 0.000137345224512231 1538 1.31045037065741 -1.36292646884883 -1 3.86188425519055 2646 4533 3864 4030 4640 2707 3536 1538 2925 4285 2182 3887 M11073 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENES_INVOLVED_IN_IMMUNE_RESPONSE.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. 15/18 Gene Ontology BP GO:0002204 3.48887947661276e-05 3.78762393949584e-05 1330 3072.45454545455 3538 3.17175891489696e-06 1202 1.07904424455233 0.962660181341171 1 5.03606442682451 1330 4550 3698 3538 4263 1789 1202 2309 4116 3815 3187 3888 M13217 GO_SPERM_EGG_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_EGG_RECOGNITION.html The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. 36/76 Gene Ontology BP GO:0035036 1.30511335200311e-05 1.48222905220172e-05 4520 3338.09090909091 3538 1.1864737222136e-06 1978 2.27470256204483 2.33975482556021 1 11.7419701275413 4520 3095 2398 1978 4075 4102 3538 3309 2217 3549 3938 3889 M15559 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 41/54 Gene Ontology BP GO:1901030 3.4088472741649e-06 4.1609040836016e-06 2365 3414.45454545455 3538 3.09895686918501e-07 2364 1.42894745055055 1.70900358222449 1 8.18500309926752 2364 3938 3538 3818 3785 2836 3388 2899 3559 4276 3158 3890 M12451 GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FOLIC_ACID_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. 12/12 Gene Ontology BP GO:0009396 9.06435521722117e-05 9.60957959118936e-05 2640 3562.36363636364 3539 8.24066245894131e-06 2009 1.31271559053059 1.44145106777629 1 5.57830138532358 2639 3553 3494 4163 4375 3539 4431 2009 4294 3496 3193 3891 M13802 GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMOSOME_ORGANIZATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. 107/128 Gene Ontology BP GO:2001251 2.5917703689849e-06 3.23571438875416e-06 430 2641.81818181818 3539 2.35615765663285e-07 427 1.20970460633985 1.38730235233155 1 7.05441784689029 427 3890 4100 3817 3698 1458 1287 1017 3539 4479 1348 3892 M13836 GO_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOTYPE_SWITCHING.html The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 15/18 Gene Ontology BP GO:0045190 3.48887947661276e-05 3.78762393949584e-05 1335 3080.09090909091 3539 3.17175891489696e-06 1203 1.07904424455233 0.962660181341171 1 5.03606442682451 1331 4551 3699 3539 4264 1790 1203 2380 4117 3819 3188 3893 M12238 GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NEUROTRANSMITTER_TRANSPORT.html Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 19/21 Gene Ontology BP GO:0051589 5.85937383078831e-07 8.99494108698713e-07 4655 3437.54545454545 3540 5.32670490122386e-08 2420 1.66280612806382 -1.96569799303072 -1 10.7367710643581 4653 2846 3005 2420 2991 4031 3540 3573 3682 3860 3212 3894 M14018 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS_INVOLVED_IN_IMMUNE_RESPONSE.html The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. 15/18 Gene Ontology BP GO:0002208 3.48887947661276e-05 3.78762393949584e-05 1335 3071.27272727273 3540 3.17175891489696e-06 1204 1.07904424455233 0.962660181341171 1 5.03606442682451 1332 4552 3700 3540 4265 1791 1204 2273 4118 3820 3189 3895 M15019 GO_NUCLEAR_ENVELOPE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. 92/100 Gene Ontology BP GO:0006998 1.47561654261936e-07 3.23412330325384e-07 2440 3361.54545454545 3541 1.34146967417646e-08 2070 1.33265425707993 1.37806008402057 1 9.22144577103959 2437 4128 4004 4234 2070 2832 3243 3584 2710 4194 3541 3896 M12234 GO_GPI_ANCHOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GPI_ANCHOR_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. 31/33 Gene Ontology BP GO:0006505 3.80672494920809e-05 4.12594716717103e-05 470 2577.36363636364 3543 3.46071892699038e-06 467 0.887763419917478 -0.890870336788701 -1 4.08767887312283 467 3965 3985 3543 4271 787 539 759 4039 4383 1613 3897 M11832 GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_DIVERSIFICATION_OF_IMMUNOGLOBULINS.html The somatic process that results in the generation of sequence diversity of immunoglobulins. 25/29 Gene Ontology BP GO:0016445 1.01910472206967e-05 1.16852988462055e-05 1915 3198.90909090909 3544 9.26463129902883e-07 1224 1.14521036882004 1.03640244591855 1 5.98303848231319 1912 3991 3839 3544 4033 2022 1224 3388 4001 3830 3404 3898 M14362 GO_GOLGI_RIBBON_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GOLGI_RIBBON_FORMATION.html The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. 13/13 Gene Ontology BP GO:0090161 7.15461151467517e-06 8.34764477878223e-06 1470 2593.72727272727 3544 6.50421343842328e-07 292 0.76812199655955 -0.827905075040051 -1 4.09683153581893 1467 3544 3694 4397 3962 1137 292 811 4305 4132 790 3899 M12186 GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme. 20/35 Gene Ontology BP GO:0051770 5.66373138129171e-06 6.68866551196709e-06 3845 3297.45454545455 3545 5.14885996562419e-07 2249 1.97719626019869 -1.65368166167828 -1 10.928864331411 3845 3169 2415 2432 3913 3900 2761 3835 4208 2249 3545 3900 M13951 GO_INTERSTRAND_CROSS_LINK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSTRAND_CROSS_LINK_REPAIR.html Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. 45/49 Gene Ontology BP GO:0036297 4.18223189869246e-07 6.85933204956504e-07 2400 3311.18181818182 3546 3.80202972158275e-08 1671 1.0643029327247 1.12667448488467 1 6.9667291733573 2398 3933 3957 4432 2801 2256 1671 2991 4346 4092 3546 3901 M16619 GO_NUCLEOTIDE_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_SALVAGE.html Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. 12/14 Gene Ontology BP GO:0043173 3.3776071073935e-06 4.12385354780949e-06 4565 3611.63636363636 3546 3.07055662996694e-07 2641 1.11040454332919 -0.954679442755228 -1 6.33983428453615 4562 3546 3382 3462 3784 4472 3093 2641 3922 3077 3787 3902 M13298 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_GAP_FILLING.html Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. 26/30 Gene Ontology BP GO:0006297 6.81274081553759e-05 7.27891688052731e-05 1825 3385.54545454545 3547 6.19359254077682e-06 1824 0.837724913742979 0.949728893251653 1 3.62800403048359 1824 3731 3852 3547 4343 2537 2046 3016 4500 4376 3469 3903 M15348 GO_REGULATION_OF_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPIRATION.html Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds. 28/34 Gene Ontology BP GO:0043457 1.59830311246008e-05 1.79635371552579e-05 1305 2945.63636363636 3547 1.45301338570265e-06 705 1.44223403004646 1.29191776137875 1 7.27346211696837 1304 4480 3547 4210 4116 1056 705 2234 4391 4107 2252 3904 M11352 GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_LIGATION_INVOLVED_IN_DNA_REPAIR.html The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair. 12/12 Gene Ontology BP GO:0051103 6.00264320165889e-06 7.06023731479242e-06 3015 3194.18181818182 3548 5.45696325434405e-07 1618 0.945923083728037 0.823331801974087 1 5.14558800429756 3015 3548 3591 3969 3929 2059 1618 2369 4219 3844 2975 3905 M12508 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS.html Any process that activates or increases the frequency, rate or extent of response to oxidative stress. 13/22 Gene Ontology BP GO:1902884 6.50242454974146e-06 7.6191844447109e-06 1870 2822.54545454545 3548 5.91131251699636e-07 530 1.21459422224593 -1.26701234560408 -1 6.59584161869919 1869 4052 3548 4223 3943 1363 1564 530 4330 4315 1311 3906 M13535 GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSFERASE_ACTIVITY.html Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. 384/474 Gene Ontology BP GO:0051348 5.28810866668805e-08 2.04581932255101e-07 3370 3354.72727272727 3548 4.80737163072506e-09 1076 1.69821109895689 1.98497559978063 1 12.146496459223 3370 3594 3464 3548 1076 3617 4323 3659 2844 3980 3427 3907 M16063 GO_PEPTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. 20/24 Gene Ontology BP GO:0043171 1.98900531766158e-06 2.55094866126774e-06 1780 2795.72727272727 3549 1.80818828719117e-07 1140 1.48364964072126 -1.4764327915446 -1 8.84289934443282 1778 3757 3549 4173 3594 1997 1459 1140 3983 3921 1402 3908 M13533 GO_REGULATION_OF_CENTROSOME_DUPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_DUPLICATION.html Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. 36/42 Gene Ontology BP GO:0010824 9.31000512056388e-07 1.32597042626213e-06 3960 3701.09090909091 3550 8.46364460035751e-08 3090 0.925343121245974 -0.937360045037328 -1 5.75648930402586 3960 3090 3889 3495 3236 4023 4505 3521 4325 3550 3118 3909 M15283 GO_CHROMATIN_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMATIN_SILENCING.html Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. 58/107 Gene Ontology BP GO:0006342 1.07566790044038e-06 1.49539370802183e-06 3345 3385.45454545455 3551 9.7788038761614e-08 1618 1.49157272416126 1.25003941080613 1 9.2641026145017 3341 3656 3497 3551 3312 3166 3916 1618 3845 3763 3575 3910 M12936 GO_RESPONSE_TO_ISCHEMIA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISCHEMIA.html Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. 39/46 Gene Ontology BP GO:0002931 3.40239251199388e-05 3.70063869993164e-05 4390 3595.36363636364 3553 3.09313193869467e-06 3041 1.6881022749288 -1.74412567363761 -1 7.96085124986787 4390 3944 3058 3686 4256 3400 3347 3041 3180 3553 3694 3911 M11451 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. 11/12 Gene Ontology BP GO:0070202 0.00186042329055271 0.00190337501559845 1140 2997.72727272727 3554 0.000169272583359219 313 0.885567172416282 0.885567172416282 1 2.4869478576083 1136 4074 3835 3554 4538 1582 313 2341 4460 4254 2888 3912 M13056 GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADRENERGIC_RECEPTOR_SIGNALING_PATHWAY.html A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. 14/38 Gene Ontology BP GO:0071875 1.32930235021938e-05 1.50786051574129e-05 4295 3549.90909090909 3555 1.20846398391715e-06 2433 1.77899801942545 -2.24735911358364 -1 9.14421100077627 4294 3224 2578 3131 4080 4371 3555 4612 2433 2955 3816 3913 M11175 GO_RENAL_VESICLE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_RENAL_VESICLE_DEVELOPMENT.html The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. 9/19 Gene Ontology BP GO:0072087 1.07222657132756e-05 1.22581578289611e-05 3725 3053.63636363636 3556 1.07223174487689e-06 1004 2.50295450860788 -2.36373199356034 -1 13.1543786877804 3725 2571 4282 1558 4059 3556 3844 1004 1498 3006 4487 3914 M11611 GO_REGULATION_OF_INTERLEUKIN_10_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_10_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-10 secretion. 8/20 Gene Ontology BP GO:2001179 1.03656551707661e-05 1.18650414537699e-05 3920 3256.45454545455 3556 1.03657035221467e-06 1656 1.33660958590047 1.19362378840882 1 6.9923237918534 3918 2082 4316 2017 4053 3521 1656 3657 3556 2804 4241 3915 M14496 GO_ENDOTHELIAL_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDOTHELIAL_CELL_PROLIFERATION.html The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. 31/38 Gene Ontology BP GO:0001935 5.80366124492055e-06 6.84870296033866e-06 4145 3169 3557 5.27606959563366e-07 1773 1.92801579569347 -1.76871933903181 -1 10.6328411542826 4145 2363 2169 2113 3916 3404 3674 4085 3557 1773 3660 3916 M13369 GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell. 13/20 Gene Ontology BP GO:0050857 6.17914180018769e-06 7.26232553581039e-06 3560 3224.09090909091 3558 5.61741741419688e-07 1333 2.11502464095244 -2.18117682376784 -1 11.6170169284574 3558 3218 1915 2157 3934 4042 4153 2734 4510 1333 3911 3917 M10296 GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_ACTIVATION_CASCADE.html Any process that modulates the frequency, rate or extent of protein activation cascade. 28/46 Gene Ontology BP GO:2000257 3.60561421001034e-07 6.12967589301356e-07 4070 3439.90909090909 3559 3.27783163721836e-08 1952 2.2727124831104 -2.51791513144701 -1 15.1249690869094 4069 4197 1952 4496 2701 4151 3248 3559 4249 2722 2495 3918 M15085 GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. 106/158 Gene Ontology BP GO:0043467 4.59429523139598e-07 7.39697429470087e-07 3185 3577.90909090909 3559 4.17663290075481e-08 2582 1.57135400841176 1.84588100788899 1 10.2840957970787 3181 4359 3559 4589 2854 2889 2582 3489 3937 4023 3895 3919 M11924 GO_NUCLEAR_PORE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. 16/17 Gene Ontology BP GO:0006999 0.0194191165973042 0.0196428585928819 1555 3388.18181818182 3560 0.00178115229410616 1553 0.778616869111744 0.709859559668884 1 1.32113579183795 1553 4047 3893 3560 4588 2677 2056 2689 4560 4248 3399 3920 M13525 GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DOLICHOL_LINKED_OLIGOSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. 20/23 Gene Ontology BP GO:0006488 0.000108286771687047 0.000114201801600143 1045 2960.63636363636 3561 9.84473655142674e-06 1043 0.990958074402685 -0.998368608218293 -1 4.10311523868592 1043 4530 3940 3561 4396 1724 1148 1216 4434 4235 2340 3921 M16610 GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_OLIGOSACCHARIDE_LIPID_INTERMEDIATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. 20/23 Gene Ontology BP GO:0006490 0.000108286771687047 0.000114201801600143 1045 2933.81818181818 3562 9.84473655142674e-06 910 0.990958074402685 -0.998368608218293 -1 4.10311523868592 1044 4531 3941 3562 4397 1725 1149 910 4435 4237 2341 3922 M12626 GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE.html The process that reduces the force with which blood travels through the systemic arterial circulatory system. 9/15 Gene Ontology BP GO:0003085 6.36507197446865e-06 7.46576251504982e-06 3140 3368.18181818182 3563 6.36509020590569e-07 1820 2.22266458106573 -2.31413825467901 -1 12.1852160642342 3136 3563 4378 3340 3956 3824 3989 4621 2342 1820 2081 3923 M10600 GO_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. 32/41 Gene Ontology BP GO:0031063 2.00124740223882e-06 2.56594217762944e-06 3520 3507.63636363636 3564 1.81931747517425e-07 2936 1.64942778419629 2.24390511445416 1 9.83908241729819 3517 3961 3165 3564 3595 3844 2936 3399 3644 3858 3101 3924 M14082 GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 22/44 Gene Ontology BP GO:0044058 1.83271472267351e-06 2.37075941189876e-06 3805 3356.09090909091 3565 1.66610568129293e-07 1407 3.45501679356788 -1.91502883614428 -1 20.8616131097635 3805 3457 1407 4108 3565 3728 3337 3923 3367 2584 3636 3925 M11209 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html The directed movement of a protein to a specific location in the endoplasmic reticulum. 126/216 Gene Ontology BP GO:0072599 0.00917842821868216 0.00930643419078842 1970 3565.36363636364 3567 0.000837904172941005 1970 0.79959053962148 -0.644769436659098 -1 1.63972711387734 1970 4389 4195 2684 4573 2789 3235 2572 4630 4615 3567 3926 M11730 GO_RRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_TRANSCRIPTION.html The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. 21/27 Gene Ontology BP GO:0009303 6.85826582709882e-06 8.01796756117859e-06 4135 3232.81818181818 3567 6.2348065519144e-07 416 1.97513264867197 1.2384000753169 1 10.749527956413 4135 2447 2594 3145 3951 4228 4258 3567 416 4123 2697 3927 M12200 GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 63/100 Gene Ontology BP GO:0009118 1.07154022380676e-07 2.66909885512466e-07 4115 3446.18181818182 3567 9.74127523634186e-09 1798 1.54789236399919 -1.31771602805574 -1 10.8683847567737 4112 3900 3446 4240 1798 4264 3318 3025 3567 3714 2524 3928 M12485 GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. 105/127 Gene Ontology BP GO:2001243 8.69104449379646e-08 2.45384890956523e-07 3570 3488.54545454545 3567 7.90094985194003e-09 1575 1.63164385196455 1.81807242099888 1 11.5268608135114 3567 3889 3247 4013 1575 3677 3531 3305 3312 3939 4319 3929 M14220 GO_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_K4_METHYLATION.html The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. 33/38 Gene Ontology BP GO:0051568 0.000350033619759084 0.000362579348339051 4480 3479.18181818182 3568 3.18263022439607e-05 2003 1.88918200021762 -2.24872541994912 -1 6.90181391053767 2003 4477 3568 4279 4479 2854 2635 3021 3651 4263 3041 3930 M15607 GO_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of ATP metabolic process. 63/100 Gene Ontology BP GO:1903578 1.07154022380676e-07 2.66909885512466e-07 4115 3425.18181818182 3568 9.74127523634186e-09 1799 1.54789236399919 -1.31771602805574 -1 10.8683847567737 4113 3901 3447 4241 1799 4265 3319 2784 3568 3715 2525 3931 M12241 GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEIC_ACID_PHOSPHODIESTER_BOND_HYDROLYSIS.html The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. 236/275 Gene Ontology BP GO:0090305 2.29160643864802e-07 4.34863163092547e-07 3570 3770.27272727273 3569 2.08327879759163e-08 2406 1.25276556597781 1.16365561507097 1 8.48800248370166 3569 4640 4167 4616 2406 3350 2787 3554 3284 4559 4541 3932 M16577 GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHAPERONE_MEDIATED_PROTEIN_FOLDING.html The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. 58/65 Gene Ontology BP GO:0061077 2.33715043570383e-07 4.40955339112988e-07 2205 3273.18181818182 3569 2.12468243998997e-08 2203 1.51790864843317 1.62543202742841 1 10.2984948970336 2203 3909 3569 3967 2421 3341 3785 2263 3990 3764 2793 3933 M14442 GO_MITOCHONDRIAL_FUSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FUSION.html Merging of two or more mitochondria within a cell to form a single compartment. 18/23 Gene Ontology BP GO:0008053 0.0255378502594682 0.0258040428354627 1640 3276.72727272727 3570 0.00234901868073224 1637 1.42577629942242 -1.42577629942242 -1 2.33090613785602 1637 4545 3849 3570 4591 1869 1828 3191 4247 4164 2553 3934 M15331 GO_FLAVONOID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FLAVONOID_METABOLIC_PROCESS.html The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. 7/29 Gene Ontology BP GO:0009812 3.77344355011681e-05 4.09082778161546e-05 3775 3121.36363636364 3571 3.77350762659116e-06 19 6.11956229948492 6.84493324439396 1 28.8683629865736 3775 3571 4549 1483 4286 4416 3711 1828 19 3165 3532 3935 M15519 GO_CELLULAR_COPPER_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COPPER_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. 15/17 Gene Ontology BP GO:0006878 3.84409213147925e-08 1.97691467186943e-07 4350 3323 3571 3.49462927149784e-09 684 1.26949918623365 -1.16829856896234 -1 9.07195855085703 4348 995 3410 4504 684 3571 3593 3466 4235 3476 4271 3936 M14726 GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EARLY_ENDOSOME_TO_GOLGI_TRANSPORT.html The directed movement of substances from early endosomes to the Golgi. 15/16 Gene Ontology BP GO:0034498 9.32171350594431e-07 1.32723173020682e-06 2835 3481.18181818182 3572 8.47428859608137e-08 2438 1.34076963247858 -1.40757388720709 -1 8.39100303427998 2832 4277 3669 4198 3237 3070 2438 3572 4006 3822 3172 3937 M15204 GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_C21_STEROID_HORMONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. 15/22 Gene Ontology BP GO:0006700 5.66813534898981e-08 2.06206675362389e-07 4260 3387.81818181818 3572 5.15285045002281e-09 1158 1.62552339907803 -0.937422483609087 -1 11.61572818697 4257 3779 2940 3417 1158 3987 4276 4297 2455 3128 3572 3938 M16727 GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MISFOLDED_OR_INCOMPLETELY_SYNTHESIZED_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. 19/19 Gene Ontology BP GO:0006515 1.91504523416904e-05 2.13532362199582e-05 2265 3214.90909090909 3572 1.74096536760385e-06 1914 0.709794065149773 -0.862913122893959 -1 3.46468304258931 2261 4526 3974 3572 4153 2147 1914 2034 4345 4332 2106 3939 M11981 GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HYDROLASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. 896/1152 Gene Ontology BP GO:0051345 3.23900988989059e-08 1.97691467186943e-07 3810 2769.18181818182 3574 3.23900993710092e-09 477 1.95286355343853 -1.78628133982352 -1 14.0162233507342 3808 1196 4337 1107 605 3574 3843 4491 2538 477 4485 3940 M12169 GO_LATERAL_MESODERM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LATERAL_MESODERM_DEVELOPMENT.html The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. 6/14 Gene Ontology BP GO:0048368 0.000355739462094893 0.000368407682423222 3155 3692.81818181818 3575 3.55796422682827e-05 2745 1.23411841237841 1.05594340819863 1 4.46020723201492 3152 3575 4351 3678 4485 3570 2986 4153 4372 3554 2745 3941 M16972 GO_AMINE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. 16/24 Gene Ontology BP GO:0009309 4.62128973595884e-06 5.50790500548578e-06 3980 3449.81818181818 3575 4.2011813121864e-07 2216 1.95286757475306 1.33374422481312 1 10.9707791160202 3980 3796 2951 3118 3878 4184 3053 3575 2216 3891 3306 3942 M16316 GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_MEDIATED_IMMUNITY.html Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. 16/23 Gene Ontology BP GO:0002888 1.90323020947166e-06 2.45447066648327e-06 4635 3459.36363636364 3576 1.73021077815176e-07 2138 2.44430051146113 -2.79329915071775 -1 14.6860031079988 4635 4027 2138 2164 3576 4431 3529 3531 3914 2409 3699 3943 M12348 GO_ERROR_FREE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_FREE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. 22/26 Gene Ontology BP GO:0070987 5.69757609970899e-05 6.11411937083624e-05 1975 3506.45454545455 3577 5.1797487830018e-06 1971 0.697083984495148 0.768636308701999 1 3.05690643734689 1971 4016 3946 3577 4320 2471 2706 3018 4612 4466 3468 3944 M15604 GO_HEME_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEME_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. 20/21 Gene Ontology BP GO:0006783 1.90630558001123e-06 2.45714128176404e-06 1230 3242.27272727273 3577 1.73300657439259e-07 1227 0.889065718033092 -0.908477916457965 -1 5.26932786416758 1227 4507 3875 4434 3577 1989 1787 2837 4443 4086 2903 3945 M10410 GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_UBIQUITINATION_INVOLVED_IN_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. 110/127 Gene Ontology BP GO:2000058 8.90426606965025e-06 1.02935528005174e-05 3155 3573.81818181818 3579 8.09482009902233e-07 2187 1.42033599420772 -1.20867155825533 -1 7.53199792180282 3151 4358 4073 3256 3999 3308 2940 4019 2187 4442 3579 3946 M12677 GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar. 49/63 Gene Ontology BP GO:0009201 6.63270533603055e-05 7.09307697737305e-05 740 3063.63636363636 3580 6.02991391968487e-06 740 0.929852134068364 -0.916467677835115 -1 4.05069633640911 740 3928 4077 3580 4339 1891 1511 2202 4114 4443 2875 3947 M16611 GO_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOCYTE_DIFFERENTIATION.html The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. 25/43 Gene Ontology BP GO:0030224 5.08233412988989e-07 8.00003406846335e-07 3045 3351.90909090909 3580 4.62030482180604e-08 1690 2.63341577044545 2.76928529447081 1 17.2147128348439 3045 4209 1690 4132 2922 3738 3366 3904 3580 2652 3633 3948 M10928 GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 22/28 Gene Ontology BP GO:0015986 0.169821759162267 0.170665366173224 1840 3565.45454545455 3581 0.0167772006876785 1769 0.730589232803646 -0.730589232803646 -1 0.492336399157023 1840 4548 4035 3581 4652 2900 1769 3308 4638 4465 3484 3949 M13085 GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION.html The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. 13/16 Gene Ontology BP GO:0071425 5.45194399962708e-07 8.47574187446201e-07 3840 3496.72727272727 3581 4.95631395518592e-08 2648 1.64582836301172 1.76290969879841 1 10.671853868373 3840 4283 3193 3995 2958 3581 2648 3732 4385 2795 3054 3950 M12843 GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_COUPLED_PROTON_TRANSPORT_DOWN_ELECTROCHEMICAL_GRADIENT.html The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. 22/28 Gene Ontology BP GO:0015985 0.169821759162267 0.170665366173224 1845 3558.90909090909 3582 0.0167772006876785 1770 0.730589232803646 -0.730589232803646 -1 0.492336399157023 1841 4549 4036 3582 4653 2901 1770 3224 4639 4468 3485 3951 M14959 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 90/103 Gene Ontology BP GO:0043620 1.81302900866932e-06 2.34921302627077e-06 2385 3269.81818181818 3583 1.64820954799607e-07 1878 1.72943499386889 2.0031467835652 1 10.3933543684965 2381 4129 3250 3838 3560 1878 2180 3583 3712 3853 3604 3952 M12929 GO_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_BINDING.html Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 126/163 Gene Ontology BP GO:0051101 1.16355840131586e-05 1.3276207065529e-05 3015 3623.90909090909 3584 1.05778595937053e-06 3014 1.66532717401459 -1.58384528650947 -1 8.65207220113508 3014 3885 3348 3584 4056 3249 4277 3288 4046 4003 3113 3953 M11047 GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. 168/342 Gene Ontology BP GO:0050851 2.70063156043962e-06 3.36440124517417e-06 2190 3282.36363636364 3586 2.45512261421096e-07 2154 1.59956272038759 -1.50602701097867 -1 9.33509288298938 2187 4339 3984 3586 3706 2562 2705 2154 4150 4399 2334 3954 M15350 GO_REGULATION_OF_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TELOMERE_CAPPING.html Any process that modulates the frequency, rate or extent of telomere capping. 25/26 Gene Ontology BP GO:1904353 1.61408939000843e-06 2.12397000331144e-06 4595 3628.36363636364 3587 1.46735506748173e-07 1605 1.75019701848277 -1.49208797279516 -1 10.6021686181548 4593 3451 3218 2458 3501 4273 4052 4598 1605 3587 4576 3955 M11179 GO_BONE_CELL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BONE_CELL_DEVELOPMENT.html The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 26/29 Gene Ontology BP GO:0098751 1.41133392312132e-06 1.88867896010454e-06 3930 3351.27272727273 3588 1.283031662286e-07 1094 1.62327493698745 -1.80287881274134 -1 9.91444026940711 3930 4204 3359 2989 3445 4146 3588 2199 4240 3670 1094 3956 M13848 GO_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLESION_SYNTHESIS.html The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. 46/55 Gene Ontology BP GO:0019985 9.84143011355884e-07 1.38680116046e-06 3590 3699.09090909091 3588 8.9467586509133e-08 3264 1.29822053168597 1.36347240132682 1 8.09441179712791 3588 3922 3527 3511 3264 3316 3519 3888 3745 4021 4389 3957 M12992 GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of carbohydrate derivative. 532/665 Gene Ontology BP GO:1901137 1.99039367943222e-08 1.97691467186943e-07 4135 3009 3589 1.99039369725972e-09 166 1.93020265411906 2.29726627460496 1 13.8522676453803 4132 2120 4399 3589 166 4054 4118 3295 2001 1277 3948 3958 M14809 GO_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 141/173 Gene Ontology BP GO:0071156 7.5809346660595e-06 8.82072743215175e-06 1675 2840.81818181818 3589 6.89178253561097e-07 1313 1.40065477146358 1.54673569990263 1 7.52743314855975 1675 3616 3854 3833 3972 1471 1313 1592 3589 4325 2009 3959 M14401 GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. 40/71 Gene Ontology BP GO:0042304 2.55451178877826e-06 3.19409261355881e-06 3490 3488.27272727273 3590 2.32228614084845e-07 2099 1.32635176841637 -1.24467927253939 -1 7.75360232571081 3489 3393 3590 3217 3691 3919 3972 2927 4293 3781 2099 3960 M10774 GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. 27/30 Gene Ontology BP GO:0033158 1.97999319187652e-06 2.54079104296785e-06 3145 3430.27272727273 3592 1.79999543078773e-07 859 1.50101385399357 1.15029858930519 1 8.95052476915039 3145 4487 3598 3250 3592 2561 859 4617 3547 4201 3876 3961 M12431 GO_PROTEIN_LOCALIZATION_TO_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MEMBRANE.html A process in which a protein is transported to, or maintained in, a specific location in a membrane. 441/589 Gene Ontology BP GO:0072657 3.46533802165212e-08 1.97691467186943e-07 3845 3161.81818181818 3592 3.15030734203321e-09 576 1.83490109804268 -1.54199681402951 -1 13.1627436495517 3842 3592 3427 2578 576 3137 4095 4005 1876 4034 3618 3962 M11729 GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. 84/110 Gene Ontology BP GO:0033238 9.99127555236847e-08 2.57982072081111e-07 3970 3440.63636363636 3593 9.08297818738285e-09 1735 1.77648831757986 -1.25340671969419 -1 12.5184803573581 3969 4135 3515 3236 1735 3593 2969 3769 2574 3851 4501 3963 M11531 GO_BLASTOCYST_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_BLASTOCYST_FORMATION.html The initial formation of a blastocyst from a solid ball of cells known as a morula. 25/34 Gene Ontology BP GO:0001825 6.53683881592447e-05 6.99377121418638e-05 4240 3573.54545454545 3594 5.94275732042425e-06 1708 1.32945217864659 1.0260152278841 1 5.84885486673211 4239 3988 3588 3148 4338 3594 1708 3915 3419 4137 3235 3964 M11645 GO_RESPONSE_TO_EXOGENOUS_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_EXOGENOUS_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. 33/62 Gene Ontology BP GO:0043330 5.33994966328461e-05 5.73299164357713e-05 1160 2794.90909090909 3594 4.85461752873571e-06 572 1.30277191465143 -1.40990024421226 -1 5.85058622346657 1156 3959 3594 4018 4318 1292 2158 572 4411 3723 1543 3965 M16761 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. 35/43 Gene Ontology BP GO:1902175 3.06957202431193e-08 1.97691467186943e-07 3325 3353.54545454545 3594 2.79052006103676e-09 434 1.26630720054812 1.48993003732096 1 9.04886395707361 3322 3956 3705 3248 434 3713 3594 3426 3415 4303 3773 3966 M14717 GO_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEPHOSPHORYLATION.html The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. 259/325 Gene Ontology BP GO:0016311 3.41385966807189e-08 1.97691467186943e-07 4275 3218.09090909091 3595 3.10350883731509e-09 553 1.62532308414192 -1.4343952079301 -1 11.646408811673 4275 1410 3326 3595 553 3831 4536 3849 2991 3351 3682 3967 M12788 GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_SPROUTING_ANGIOGENESIS.html Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. 22/24 Gene Ontology BP GO:1903671 5.65028126535321e-07 8.7344713381025e-07 4655 3321.72727272727 3596 5.13662065138266e-08 812 1.63458509878027 1.77193481636175 1 10.5751407096435 4652 812 2586 2186 2972 4235 4385 4572 2083 3596 4460 3968 M11964 GO_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PROCESSING.html Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. 857/1051 Gene Ontology BP GO:0006396 1.82677166508308e-06 2.36372874238921e-06 1370 3514.45454545455 3597 1.82677316677744e-07 1368 0.956783744243483 0.953849163795409 1 5.69667552917229 1368 4605 4335 4652 3597 2583 1803 3329 4281 4619 3487 3969 M10468 GO_CELLULAR_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 56/70 Gene Ontology BP GO:0006073 2.05649252304059e-06 2.6345979376949e-06 2525 3494.90909090909 3598 1.86954040489931e-07 1885 1.07459193441889 1.19199828455914 1 6.35738648237514 2521 4422 4002 4274 3598 2671 1885 3313 4232 4386 3140 3970 M16522 GO_RESPONSE_TO_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_STARVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. 187/270 Gene Ontology BP GO:0042594 1.1723223431624e-07 2.82053557561036e-07 4610 3272.72727272727 3598 1.06574764148399e-08 1696 2.07742981066506 -1.78859005222262 -1 14.5714400054624 4606 3602 1696 2783 1874 4250 3998 3661 3129 3598 2803 3971 M12331 GO_GLUCAN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. 56/70 Gene Ontology BP GO:0044042 2.05649252304059e-06 2.6345979376949e-06 2525 3506.54545454545 3599 1.86954040489931e-07 1886 1.07459193441889 1.19199828455914 1 6.35738648237514 2522 4423 4003 4275 3599 2672 1886 3431 4233 4387 3141 3972 M13610 GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS.html Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. 196/249 Gene Ontology BP GO:0048872 9.35242334908032e-08 2.50783780632741e-07 4415 3387.72727272727 3601 8.50220340605577e-09 1668 1.78952858334166 -1.4850648868227 -1 12.634938149434 4413 3601 2978 2195 1668 4243 4652 4627 2759 2312 3817 3973 M16056 GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_PROCESS.html Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. 107/124 Gene Ontology BP GO:0048524 6.98222623663102e-07 1.04129162432834e-06 3625 3605.27272727273 3604 6.3474804114623e-08 2887 1.22818705874957 -1.21517993191054 -1 7.81659899115703 3625 4123 4029 4261 3085 3604 3340 3324 3021 4359 2887 3974 M10940 GO_CELLULAR_RESPONSE_TO_SUPEROXIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_SUPEROXIDE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. 14/21 Gene Ontology BP GO:0071451 0.00512019813721078 0.00520521781351142 1665 3179.90909090909 3605 0.000466559424437779 764 1.79607467612897 -1.79607467612897 -1 4.31331222508206 1662 4574 3605 4049 4561 1480 764 3085 4627 4177 2395 3975 M15072 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation. 17/39 Gene Ontology BP GO:0046636 4.32156901022586e-06 5.18014272476495e-06 4185 3662.72727272727 3605 3.92870681756486e-07 2880 1.5078463523861 1.00953969402292 1 8.48833463758159 4183 2880 3176 3188 3857 4321 3212 4171 3605 3388 4309 3976 M11899 GO_ADP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ADP_METABOLIC_PROCESS.html The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. 44/64 Gene Ontology BP GO:0046031 2.16704239195937e-07 4.18704164069861e-07 3525 3596.09090909091 3606 1.9700387321975e-08 2366 1.5117525319768 1.76663255703303 1 10.2929578180723 3523 3071 3183 4119 2366 4541 4597 4220 2672 3659 3606 3977 M15152 GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 14/21 Gene Ontology BP GO:0071450 0.00512019813721078 0.00520521781351142 1665 3171.63636363636 3606 0.000466559424437779 765 1.79607467612897 -1.79607467612897 -1 4.31331222508206 1663 4575 3606 4050 4562 1481 765 2977 4628 4185 2396 3978 M12342 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_CONTRACTION.html Any process that increases the frequency, rate or extent of cardiac muscle contraction. 10/16 Gene Ontology BP GO:0060452 1.04308971186189e-07 2.64207753363821e-07 4345 3151.36363636364 3609 9.48263419380079e-09 1259 2.62160063519276 -3.07150567638319 -1 18.4982834069856 4027 4063 2132 2826 1770 4344 4345 3609 1259 2680 3610 3979 M10984 GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_I_KAPPAB_KINASE_NF_KAPPAB_SIGNALING.html The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. 118/163 Gene Ontology BP GO:0007249 1.29291078273571e-05 1.46944647583518e-05 1200 3139.54545454545 3611 1.17538034642108e-06 1196 1.54007497599488 -1.52391351754329 -1 7.91956344863212 1196 4354 3611 4048 4073 2123 2485 2328 3733 4142 2442 3980 M12092 GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving guanosine-containing compounds (guanosines). 50/59 Gene Ontology BP GO:1901068 8.15675663884842e-07 1.18345458810607e-06 3615 3625.63636363636 3614 7.41523605732969e-08 3061 1.73442968378141 2.16142034019446 1 10.9810801068494 3614 3666 3187 4520 3172 3680 3270 4538 3165 3061 4009 3981 M15485 GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. 146/170 Gene Ontology BP GO:0051053 2.1265833070784e-06 2.71467548088773e-06 3615 3638.63636363636 3614 1.93325942063436e-07 2492 1.39625908079718 1.68065577623576 1 8.2746590550095 2492 4114 3994 4597 3614 3339 2557 3611 3882 4230 3595 3982 M16038 GO_PEPTIDYL_ARGININE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ARGININE_METHYLATION.html The addition of a methyl group to an arginine residue in a protein. 11/14 Gene Ontology BP GO:0018216 1.52465930828038e-05 1.71898225379903e-05 2245 3528.90909090909 3614 1.38606352243903e-06 2245 0.764385059516331 0.799241178335245 1 3.81755765017502 2245 3827 3614 4526 4104 2793 2864 3060 4312 4033 3440 3983 M10095 GO_REGULATION_OF_RESPIRATORY_BURST http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPIRATORY_BURST.html Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. 12/20 Gene Ontology BP GO:0060263 1.85620247768663e-06 2.39847545922686e-06 4430 3444.63636363636 3616 1.68745822165384e-07 1550 1.58378915061385 -1.34351902294757 -1 9.49313905733529 4430 2050 2584 3414 3569 4631 4363 3616 3784 1550 3900 3984 M16632 GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NF_KAPPAB_IMPORT_INTO_NUCLEUS.html Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. 59/106 Gene Ontology BP GO:0042346 1.21263375126643e-05 1.38225988354794e-05 3620 3592.72727272727 3616 1.10240039574618e-06 2699 1.78614428212929 -1.48042707885757 -1 9.25420841467303 3616 4150 2767 4037 4061 3830 4339 2699 3381 3310 3330 3985 M12323 GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION.html Any process that activates or increases the frequency, rate or extent of striated muscle contraction. 18/27 Gene Ontology BP GO:0045989 2.30112037184615e-06 2.9119154447104e-06 4635 3392.45454545455 3618 2.09192979885299e-07 1885 2.05958484114744 -2.46927089869162 -1 12.1917530334314 4632 2866 2162 2835 3647 4159 4572 3618 2926 1885 4015 3986 M13207 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS.html Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 36/38 Gene Ontology BP GO:0036003 2.13635194874738e-06 2.72490285568025e-06 4550 3720.72727272727 3618 1.94214002117772e-07 2503 1.88256696022658 2.02365369974732 1 11.1927416905311 4550 3414 2503 3237 3618 4156 4630 3957 3732 3548 3583 3987 M13246 GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 131/165 Gene Ontology BP GO:0072522 1.53897499968304e-07 3.31520864515054e-07 3380 3548.45454545455 3620 1.39906827939963e-08 2107 1.65453089153942 1.91320890272192 1 11.4568195167598 3380 3620 3656 3472 2107 4490 4367 3344 3064 3730 3803 3988 M16230 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway. 166/197 Gene Ontology BP GO:2001242 6.60324855646974e-08 2.17752767776426e-07 3470 3506.45454545455 3620 6.00295341333154e-09 1309 1.749781416698 1.92833256205267 1 12.4676195297633 3466 4106 3163 4224 1309 3620 3411 3779 3383 3732 4378 3989 M10793 GO_POSITIVE_REGULATION_OF_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BINDING.html Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. 181/216 Gene Ontology BP GO:0051099 1.08106260699185e-07 2.68150341997721e-07 3910 3508.18181818182 3621 9.82784236467651e-09 1805 1.50237700734866 -1.31642736693673 -1 10.5422122010831 3906 3002 3621 3243 1805 3722 4298 3592 3803 3577 4021 3990 M13902 GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of erythrocyte differentiation. 39/48 Gene Ontology BP GO:0045646 3.58187062098294e-07 6.09376380235233e-07 3300 3638.18181818182 3621 3.25624654923243e-08 2699 1.37450713531269 1.19526947184556 1 9.10647366042094 3621 3400 3296 3732 2699 4343 3024 3967 3992 3298 4648 3991 M10240 GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_BINDING.html Any process that activates or increases the frequency, rate or extent of protein binding. 115/132 Gene Ontology BP GO:0032092 1.97688649891816e-08 1.97691467186943e-07 4330 3473.81818181818 3622 1.79716956062015e-09 118 1.62707854272554 -1.24991848037088 -1 11.6591098720431 4329 3622 3243 3198 118 4236 3976 4622 3528 2876 4464 3992 M13892 GO_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_BIOSYNTHETIC_PROCESS.html The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. 121/137 Gene Ontology BP GO:0071897 3.06876188715684e-06 3.77350662287018e-06 555 2614.36363636364 3623 2.78978742523262e-07 534 1.24624998647231 1.34244587331718 1 7.18113792979079 553 3623 4001 3787 3755 735 534 1731 3708 4240 2091 3993 M14285 GO_REGULATION_OF_ACROSOME_REACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACROSOME_REACTION.html Any process that modulates the frequency, rate or extent of the acrosome reaction. 8/28 Gene Ontology BP GO:0060046 1.47974852376196e-06 1.97003430073374e-06 4430 3258.81818181818 3623 1.47974950910795e-07 1329 3.0571067415039 -1.85746910062745 -1 18.7112923429418 4428 2077 4485 1896 3506 3936 3623 4409 1329 1521 4637 3994 M15581 GO_RESPONSE_TO_OXYGEN_RADICAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_OXYGEN_RADICAL.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion. 18/25 Gene Ontology BP GO:0000305 0.000570592468418653 0.000587122236964173 2055 3300.54545454545 3623 5.18855010145905e-05 1126 1.4240128235086 -1.57088696941292 -1 4.85284784355717 2054 4540 3623 4577 4511 1881 1126 2285 4615 4167 2927 3995 M10244 GO_REGULATION_OF_VASCULOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VASCULOGENESIS.html Any process that modulates the frequency, rate or extent of vasculogenesis. 16/21 Gene Ontology BP GO:2001212 0.000105556762346312 0.0001113984157853 2370 3434.63636363636 3624 9.59652975787074e-06 1207 1.49119853741013 1.829486729011 1 6.2488512692898 2368 4561 3346 4560 4393 2002 1207 3644 4617 3624 3459 3996 M10564 GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 15/17 Gene Ontology BP GO:0046130 2.15847584940808e-06 2.74860102005905e-06 3625 3498.54545454545 3624 1.96225269740585e-07 2105 1.94303956134901 -1.92414024085436 -1 11.5480264737123 4232 3783 2615 3624 3623 4028 3771 3587 2105 2686 4430 3997 M16444 GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCONEOGENESIS.html Any process that activates or increases the frequency, rate or extent of gluconeogenesis. 13/18 Gene Ontology BP GO:0045722 2.20605406125569e-05 2.44224828622953e-05 3525 3505.09090909091 3624 2.00552380255825e-06 2086 1.16904210406874 1.15932174146779 1 5.70597589333204 3705 3237 3525 3521 4180 2996 2086 3624 4027 3928 3727 3998 M10580 GO_NITRIC_OXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NITRIC_OXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. 16/22 Gene Ontology BP GO:0046209 4.17394550119543e-06 5.01844145143729e-06 3490 3587.45454545455 3625 3.79450310929639e-07 2828 2.37821029703246 -2.91856022280083 -1 13.4886311748673 3486 4263 2828 2905 3844 3469 4107 3954 4043 3625 2938 3999 M14410 GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 24/50 Gene Ontology BP GO:0045078 7.32197088797905e-05 7.81581338420888e-05 3870 3513.72727272727 3625 6.65655871533549e-06 2527 2.04917404776192 2.26092992049343 1 8.96972602520202 3869 4219 2527 3549 4346 3627 2834 3078 3625 3216 3761 4000 M11060 GO_3_UTR_MEDIATED_MRNA_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_3_UTR_MEDIATED_MRNA_STABILIZATION.html An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. 16/16 Gene Ontology BP GO:0070935 9.78857343570586e-07 1.37977074208844e-06 3180 3576.09090909091 3626 8.89870708271729e-08 2085 1.24480426457435 0.865887777274652 1 7.75967291299995 3180 3781 3419 4516 3263 2427 2085 4638 3893 3626 4509 4001 M14995 GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_POLYMERIZATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. 42/54 Gene Ontology BP GO:0030837 2.82465903185101e-06 3.50110241747542e-06 3630 2821.18181818182 3627 2.56787514412612e-07 131 2.26093752045194 2.31226261499378 1 13.1994514618569 3627 1765 1684 1332 3727 3769 4284 4421 131 2242 4051 4002 M13159 GO_CARNITINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARNITINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. 14/16 Gene Ontology BP GO:0009437 9.67873511145168e-06 1.11249535069512e-05 3545 3695.81818181818 3628 8.79888881143969e-07 2501 0.949879509865075 -1.01040111083927 -1 4.96513952953179 3628 3542 3542 3983 4021 2501 2989 4576 4469 4183 3220 4003 M10871 GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY.html The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. 150/179 Gene Ontology BP GO:0035567 1.32187359194275e-07 3.01316750736611e-07 3870 3559.54545454545 3630 1.20170333760704e-08 1981 1.42484448301325 1.6610392553364 1 9.91444963585189 3302 3876 3870 3000 1981 4291 4560 3630 3319 3869 3457 4004 M11347 GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM.html The process in which an organism effects a change in the structure or processes of a second organism. 98/206 Gene Ontology BP GO:0035821 1.28249920928428e-06 1.74130983974315e-06 4020 3604.18181818182 3630 1.16590905174834e-07 2692 1.71919506280344 -1.60475616495551 -1 10.5724352084674 3910 3630 3373 3775 3393 4020 4020 2692 3076 3441 4316 4005 M15266 GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CARDIAC_EPITHELIAL_TO_MESENCHYMAL_TRANSITION.html A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. 28/33 Gene Ontology BP GO:0060317 1.59818054624513e-05 1.79635371552579e-05 4145 3378.27272727273 3631 1.45290196025192e-06 1544 2.41068055273972 2.53548984318675 1 12.2334672218713 4142 3713 1544 3631 4115 3419 2625 3911 3350 2377 4334 4006 M12235 GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_DEACETYLATION.html Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. 19/19 Gene Ontology BP GO:0031065 7.34923738506557e-06 8.56184315290688e-06 3635 3618.36363636364 3633 6.68114721433346e-07 2751 1.78757930298086 2.61913370549269 1 9.6630536297316 3633 3766 2945 3559 3967 4316 4480 2901 3434 4050 2751 4007 M16551 GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UNSATURATED_FATTY_ACID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. 46/71 Gene Ontology BP GO:0006636 7.11988742052604e-07 1.05775338977355e-06 3640 3610 3636 6.47262702249557e-08 2008 2.05318330736236 1.36223798364591 1 13.1280302010647 3636 3926 2008 4530 3097 3563 3172 4299 4358 2706 4415 4008 M11789 GO_SEQUESTERING_OF_METAL_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SEQUESTERING_OF_METAL_ION.html The process of binding or confining metal ions such that they are separated from other components of a biological system. 12/22 Gene Ontology BP GO:0051238 1.61224534796308e-07 3.42234379747819e-07 3640 3577.54545454545 3640 1.46567769646789e-08 2144 2.93102546544697 -3.10715128126792 -1 20.3394850919527 3640 4066 2698 3752 2144 4219 4537 3370 3964 3493 3470 4009 M16615 GO_RESPONSE_TO_LEAD_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_LEAD_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. 21/30 Gene Ontology BP GO:0010288 5.82945030680132e-07 8.96082995624267e-07 3030 3551.54545454545 3642 5.29950168314597e-08 2550 1.62375746752209 1.63755763157723 1 10.4848688039606 3030 4226 3267 3949 2988 3642 4516 2550 3728 3970 3201 4010 M16669 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_CYTOCHROME_C_TO_OXYGEN.html The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. 14/23 Gene Ontology BP GO:0006123 0.00900592502018443 0.00913351550107196 1450 3443.54545454545 3643 0.000822091306689591 1447 0.552546827887005 -0.528139167948583 -1 1.10302677928789 1447 2921 3885 4209 4572 2430 2087 3643 4530 4653 3502 4011 M11628 GO_MEMBRANE_LIPID_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEMBRANE_LIPID_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. 20/24 Gene Ontology BP GO:0046466 6.7007477148028e-08 2.18361447198576e-07 4595 3471 3644 6.09158901717617e-09 1331 1.3414095099873 -1.41588510627676 -1 9.52971979804318 4592 1961 3280 3430 1331 4506 3958 4183 3898 3398 3644 4012 M12800 GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RECEPTOR_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity. 32/41 Gene Ontology BP GO:2000272 2.76940948680674e-08 1.97691467186943e-07 3940 3219.72727272727 3646 2.51764501969881e-09 348 1.74818060590701 -1.44546973422435 -1 12.5353052034294 3937 2360 2878 3646 348 4052 4042 4047 2819 2888 4400 4013 M15547 GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8. 28/53 Gene Ontology BP GO:0045414 4.07595004721779e-06 4.90822866710776e-06 4580 3532.45454545455 3648 3.70541599888059e-07 1933 2.06383145127326 -2.05554665521459 -1 11.7120809298853 4579 4193 2305 4423 3838 4150 3551 1933 3648 3041 3196 4014 M12251 GO_POLYAMINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYAMINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. 15/17 Gene Ontology BP GO:0006595 0.00018011472015065 0.000187908922166138 2720 3358.90909090909 3649 1.63754061720127e-05 1414 1.18485814571924 1.33374422481312 1 4.65154069755767 2716 4044 3649 4169 4447 3185 3202 1716 4368 4038 1414 4015 M14513 GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving organonitrogen compound. 1625/2218 Gene Ontology BP GO:1901564 4.01487778224351e-08 1.97691467186943e-07 2810 3272.72727272727 3649 4.0148778547801e-09 852 1.86372066713953 -1.6645423046693 -1 13.371258444691 2806 3849 4498 4080 852 2984 3048 3649 2222 4278 3734 4016 M14571 GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL.html Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. 67/72 Gene Ontology BP GO:0051881 2.59306025999787e-07 4.72601229524875e-07 3285 3590 3649 2.35732778693867e-08 2511 1.77598950619039 2.03711790560165 1 12.0110219763717 3283 3649 3092 4010 2511 3230 4039 4392 3831 3289 4164 4017 M13244 GO_COVALENT_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_COVALENT_CHROMATIN_MODIFICATION.html The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. 342/403 Gene Ontology BP GO:0016569 9.04424686368839e-07 1.29366371523954e-06 2175 3520.45454545455 3650 8.22204598345426e-08 2171 1.29612287286873 1.25576933688665 1 8.12338432963583 2171 4329 4206 4335 3221 2565 2253 3886 3650 4572 3537 4018 M11089 GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 311/351 Gene Ontology BP GO:0045732 8.67660553764326e-08 2.45384890956523e-07 3580 3450.09090909091 3651 7.88782352712813e-09 1571 1.52377806341634 -1.2680555063281 -1 10.757358755681 3576 4624 4090 4055 1571 2691 3483 3804 1972 4434 3651 4019 M13180 GO_POSITIVE_T_CELL_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_T_CELL_SELECTION.html The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. 20/30 Gene Ontology BP GO:0043368 2.34219870208723e-06 2.9598685392415e-06 4165 3417.90909090909 3652 2.12927381425407e-07 2131 2.08476475777464 1.87337314627511 1 12.3262284049711 4162 3170 2131 3151 3652 4021 3960 3467 3739 2252 3892 4020 M13031 GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MUSCLE_HYPERTROPHY.html Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. 31/36 Gene Ontology BP GO:0014742 3.87846219435647e-06 4.68253362489379e-06 4180 3589.81818181818 3653 3.52588093805386e-07 2653 1.86190565836442 1.40870654164735 1 10.5961829483029 4180 3967 2969 2653 3824 3653 3230 4356 3288 3081 4287 4021 M13407 GO_REGULATION_OF_FEVER_GENERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEVER_GENERATION.html Any process that modulates the rate or extent of fever generation. 9/13 Gene Ontology BP GO:0031620 8.35783575949034e-07 1.20773322325803e-06 4500 3345.09090909091 3653 8.35783890289583e-08 1107 2.08013511991213 1.64764948817333 1 13.1725655380374 4497 1107 4425 3653 3228 3215 2362 4568 4427 1265 4049 4022 M15208 GO__DE_NOVO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_PROTEIN_FOLDING.html The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. 32/33 Gene Ontology BP GO:0006458 2.34650094634578e-06 2.96369948516475e-06 2435 3533.18181818182 3653 2.13318495373373e-07 2086 1.13837152808958 1.2461744333498 1 6.67862105716126 2431 4470 3816 4262 3653 3233 3592 2086 4589 3859 2874 4023 M15139 GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CARDIAC_MUSCLE_HYPERTROPHY.html Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. 31/36 Gene Ontology BP GO:0010613 3.87846219435647e-06 4.68253362489379e-06 4185 3589.27272727273 3654 3.52588093805386e-07 2654 1.86190565836442 1.40870654164735 1 10.5961829483029 4181 3968 2970 2654 3825 3654 3231 4340 3289 3082 4288 4024 M11459 GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LIPID_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. 22/32 Gene Ontology BP GO:0065005 2.44408875238377e-08 1.97691467186943e-07 3850 3318.54545454545 3655 2.2218988904876e-09 247 1.53149250746382 -0.851778505938814 -1 10.9675276178536 3847 3994 3214 4194 247 3655 2909 3012 4473 3290 3669 4025 M15231 GO_ISOPRENOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ISOPRENOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 25/33 Gene Ontology BP GO:0008299 2.69586945499772e-08 1.97691467186943e-07 3365 3313.81818181818 3656 2.45079044366616e-09 322 1.93832581549634 1.69806029862657 1 13.9110401872172 3363 3727 2681 4389 322 3656 2841 4108 3609 3831 3925 4026 M15721 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway. 58/65 Gene Ontology BP GO:2001238 8.66894297365444e-07 1.24726628498498e-06 4420 3794.54545454545 3657 7.88086035417402e-08 3201 1.4917533629131 -1.426325021958 -1 9.39209623982511 4419 3657 3394 3715 3201 4240 4232 3405 3421 3437 4619 4027 M15786 GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. 19/22 Gene Ontology BP GO:1902043 1.034291183176e-05 1.18477520318019e-05 4470 3535.63636363636 3657 9.40269132495919e-07 1977 2.0202201307448 -1.76219209421549 -1 10.6277807449002 4467 3173 2795 2394 4038 4335 4582 3860 1977 3614 3657 4028 M16419 GO_RRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. 19/20 Gene Ontology BP GO:0031167 2.3808820601811e-06 3.00467703445149e-06 1530 2701.27272727273 3657 2.16444057892826e-07 339 0.984208318710827 0.823064847837955 1 5.75252254747403 1529 4014 3832 4185 3657 837 339 1650 4148 3863 1660 4029 M12262 GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_GAMMA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma. 26/62 Gene Ontology BP GO:0045072 0.000122596319354566 0.000129000604693983 4370 3650.45454545455 3658 1.11457410582742e-05 2521 2.04917404776192 2.26092992049343 1 8.48845756880427 4368 4211 2572 3555 4409 4204 3658 2521 3857 3418 3382 4030 M15817 GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ERBB_SIGNALING_PATHWAY.html Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway. 35/49 Gene Ontology BP GO:1901186 9.87836220071225e-07 1.38990079588491e-06 4520 3625.63636363636 3661 8.980333305693e-08 2435 1.58690334328301 -1.53056564396907 -1 9.91783936597671 4519 3106 3204 2435 3269 4047 3939 4388 3417 3661 3897 4031 M15520 GO_RESPONSE_TO_ACIDIC_PH http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ACIDIC_PH.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. 18/28 Gene Ontology BP GO:0010447 1.08566775960981e-06 1.50659471681015e-06 4620 3417.18181818182 3662 9.86971177610276e-08 848 1.8766628543158 -1.87879154003527 -1 11.678518361271 4619 3765 2706 4147 3318 3662 3587 848 3707 3161 4069 4032 M16029 GO_HISTONE_H4_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group. 57/62 Gene Ontology BP GO:0043967 6.7647219996064e-07 1.01372790544826e-06 3050 3577.36363636364 3662 6.14974916333984e-08 2059 1.12566656913804 1.00760527342711 1 7.16883745994469 3050 3662 4040 3574 3069 3099 2059 4476 4044 4349 3929 4033 M14480 GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 15/17 Gene Ontology BP GO:0006152 2.15847584940808e-06 2.74860102005905e-06 3625 3507.18181818182 3664 1.96225269740585e-07 2106 1.94303956134901 -1.92414024085436 -1 11.5480264737123 4233 3784 2616 3625 3624 4029 3772 3664 2106 2695 4431 4034 M14673 GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. 54/68 Gene Ontology BP GO:1901028 1.43464305388092e-05 1.62220999506875e-05 2085 3500.63636363636 3664 1.30422946311274e-06 2085 1.38051925253048 1.53816806716862 1 7.02336300571077 2085 3917 3664 3011 4091 2883 3670 3414 4065 4304 3403 4035 M16661 GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AUDITORY_RECEPTOR_CELL_MORPHOGENESIS.html Any process that alters the size or shape of an auditory receptor cell. 16/25 Gene Ontology BP GO:0002093 2.28416467211078e-06 2.89342263405584e-06 3120 3606.54545454545 3665 2.07651549423949e-07 2865 1.7086142841902 1.31623171418519 1 10.1000052237997 4191 3205 3119 3726 3642 3756 3665 3117 3793 2865 4593 4036 M10436 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION.html Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. 1468/2161 Gene Ontology BP GO:0010629 1.31848942997189e-07 3.00938527582835e-07 3650 3621.72727272727 3666 1.31848950820054e-08 2056 1.7233204432768 1.86550697809056 1 12.016031520653 3647 4316 4239 4286 2056 3666 3391 2798 3010 4195 4235 4037 M12111 GO_INNER_DYNEIN_ARM_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_DYNEIN_ARM_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. 36/63 Gene Ontology BP GO:0036159 1.50532840698288e-06 1.99837177680209e-06 3780 3453.81818181818 3666 1.36848130635459e-07 2392 2.00392032987391 2.134852296084 1 12.2127949657121 3776 3695 2392 4005 3473 3418 3110 3666 3719 2746 3992 4038 M14613 GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENTERIC_NERVOUS_SYSTEM_DEVELOPMENT.html The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. 8/13 Gene Ontology BP GO:0048484 5.53469467924391e-06 6.54957638416122e-06 3755 3657.72727272727 3666 5.53470846407257e-07 2141 2.42197630687543 2.97111145505725 1 13.4366630281189 3755 3566 4503 2915 3933 3470 3666 4535 4359 2141 3392 4039 M14069 GO_CELLULAR_RESPONSE_TO_ZINC_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ZINC_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. 5/13 Gene Ontology BP GO:0071294 3.14257629963409e-05 3.42525357746484e-05 4395 3551 3668 3.14262074155472e-06 805 1.00323586277507 -0.991320738513698 -1 4.7215964407743 4392 3285 4472 2887 4259 4129 4263 805 3668 3323 3578 4040 M15614 GO_PROTEIN_PALMITOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_PALMITOYLATION.html The covalent attachment of a palmitoyl group to a protein. 21/26 Gene Ontology BP GO:0018345 2.13425315252481e-08 1.97691467186943e-07 4040 3160.45454545455 3670 1.94023015748139e-09 157 1.51520760580845 -1.24139065244687 -1 10.8497034088545 4040 3155 3132 3896 157 3670 3682 4629 982 3513 3909 4041 M10178 GO_ETHER_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ETHER_METABOLIC_PROCESS.html The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. 10/13 Gene Ontology BP GO:0018904 0.0247570746393757 0.0250205621844081 4590 3363.09090909091 3671 0.00227637646203733 1266 1.17442029850422 -1.17442029850422 -1 1.91701491275995 1749 4586 3671 4549 4615 2061 1266 2524 4587 4218 3168 4042 M13895 GO_SPERMATID_NUCLEUS_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_NUCLEUS_DIFFERENTIATION.html The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. 26/134 Gene Ontology BP GO:0007289 3.68581756763938e-05 3.99769443874733e-05 4270 3478.09090909091 3672 3.35079938202669e-06 1410 1.39970463418187 1.43541054878173 1 6.5308320706739 1878 4490 3719 4566 4269 2928 1410 3636 4268 3672 3423 4043 M14168 GO_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING.html Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. 179/252 Gene Ontology BP GO:0016458 7.19699588155797e-07 1.06818570452597e-06 2560 3534.90909090909 3672 6.54272566905159e-08 2153 1.26586232147608 1.12552148627853 1 8.04471710318195 2557 4337 4147 4328 3101 2858 3232 2153 3997 4502 3672 4044 M13490 GO_INOSITOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INOSITOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. 11/13 Gene Ontology BP GO:0006020 2.47512944375178e-06 3.10970572134018e-06 4065 3721.36363636364 3673 2.25012020765675e-07 3204 1.23350105936752 -1.74290554260015 -1 7.2183770943255 4061 3825 3242 4507 3673 3504 3656 4246 3275 3742 3204 4045 M13619 GO_OXYGEN_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXYGEN_TRANSPORT.html The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 6/19 Gene Ontology BP GO:0015671 0.000383741213135862 0.000397010371274022 3540 3808.18181818182 3673 3.83807495038721e-05 2927 1.74497126185959 -2.09765638965761 -1 6.29213362372361 3538 3576 4439 3456 4487 3721 3473 4377 4223 2927 3673 4046 M14730 GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY.html Any series of molecular signals initiated by a ligand binding to an receptor located within a cell. 184/294 Gene Ontology BP GO:0030522 5.58446038053035e-07 8.64420963094068e-07 3965 3623.81818181818 3674 5.07678345280481e-08 2400 1.656071992524 -1.63260787182805 -1 10.7237024249349 3962 3605 3674 3508 2969 4193 4590 2400 3008 4011 3942 4047 M11719 GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 50/83 Gene Ontology BP GO:0030811 1.49471140299143e-07 3.25796071963426e-07 3535 3585.81818181818 3677 1.35882864049479e-08 2081 1.51932485786546 -1.13137096226543 -1 10.5237458744716 3531 4159 3354 4260 2081 3745 3016 3677 3600 3829 4192 4048 M16295 GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. 17/20 Gene Ontology BP GO:0000028 0.00146394055810176 0.00150004743819588 3085 3892.72727272727 3679 0.000133174146629707 3081 0.546022377785399 -0.615346197269511 -1 1.55097998529788 3081 4566 3986 3253 4533 3500 3679 3394 4652 4650 3526 4049 M14629 GO_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that modulates the frequency, rate or extent of B cell proliferation. 56/96 Gene Ontology BP GO:0030888 4.33747020302198e-08 1.97691467186943e-07 4110 3341.18181818182 3680 3.94315480776234e-09 831 2.0563042138014 -2.01285386149909 -1 14.7646352382316 4110 3907 2127 4127 831 4232 3680 3568 4274 2390 3507 4050 M11127 GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ENDOTHELIAL_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of endothelial cell differentiation. 31/40 Gene Ontology BP GO:0045601 1.31497917360813e-05 1.49270507313945e-05 4135 3343.81818181818 3681 1.19544275776234e-06 1922 2.36700883935216 -2.81664947690615 -1 12.2152292004064 4131 3430 1922 3681 4077 4333 4056 2058 4026 2466 2602 4051 M13726 GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS http://www.broadinstitute.org/gsea/msigdb/cards/GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_VIA_DEATH_DOMAIN_RECEPTORS.html A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. 42/48 Gene Ontology BP GO:0008625 4.29193470801988e-08 1.97691467186943e-07 4260 3454.18181818182 3681 3.90175890159122e-09 816 1.45087867537382 -1.33790004409909 -1 10.3842719617004 4258 3681 3422 4146 816 4444 4358 3014 3145 3879 2833 4052 M11279 GO_MONOSACCHARIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MONOSACCHARIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. 63/87 Gene Ontology BP GO:0046365 2.24461251797132e-08 1.97691467186943e-07 4190 3434.81818181818 3683 2.04055685533874e-09 186 1.64360397561869 -1.46644405274089 -1 11.7786743680535 4189 3651 3158 4518 186 3683 4260 3171 3061 3713 4193 4053 M14984 GO_POSITIVE_REGULATION_OF_BONE_REMODELING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_REMODELING.html Any process that activates or increases the frequency, rate or extent of bone remodeling. 11/15 Gene Ontology BP GO:0046852 1.25875705250199e-06 1.7145774488559e-06 3925 3248.27272727273 3683 1.14432524792354e-07 1310 2.28837384578456 -2.78329637933708 -1 14.126718556222 3922 2053 1651 3098 3382 4283 4248 3683 4377 1310 3724 4054 M15182 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. 933/1288 Gene Ontology BP GO:0045944 1.36799773268356e-07 3.08246656182886e-07 2355 3406.09090909091 3684 1.36799781689737e-08 2025 1.69913150273706 1.76444850580376 1 11.8266753361121 2352 4318 4541 4604 2090 2268 2025 3863 3422 4300 3684 4055 M16049 GO_STRIATED_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRIATED_MUSCLE_ADAPTATION.html Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 27/42 Gene Ontology BP GO:0014888 3.02743108751469e-06 3.72465278958378e-06 3870 3094 3685 2.75221386689627e-07 1434 2.55597209155363 -1.3303317583455 -1 14.8624836711215 3868 2398 2030 3685 3753 3850 4618 1434 1516 3734 3148 4056 M14263 GO_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_APPETITE.html Any process which modulates appetite, the desire or physical craving for food. 11/23 Gene Ontology BP GO:0032098 2.13827264784888e-05 2.37059390765805e-05 4595 3114.45454545455 3687 1.94390311900366e-06 992 3.98074560901037 -3.73018936928746 -1 19.757191098916 4591 3824 1534 2843 4177 4452 3687 1857 992 2341 3961 4057 M15030 GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. 37/44 Gene Ontology BP GO:0031062 2.1608466124389e-06 2.75086711017188e-06 3880 3664.81818181818 3689 1.96440794075623e-07 2655 1.52671359615364 -1.64111040447971 -1 9.04886242810061 3879 3689 3415 2655 3625 4154 4546 3695 3249 4059 3347 4058 M15420 GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH.html Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death. 13/16 Gene Ontology BP GO:1903203 1.70359758619989e-05 1.90916174580638e-05 4060 3373.18181818182 3689 1.54873707124039e-06 1585 1.55115724037882 1.92676566371974 1 7.78704400912279 2699 4056 3256 2670 4129 3794 3689 1585 4057 3927 3243 4059 M15637 GO_PEPTIDE_HORMONE_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDE_HORMONE_PROCESSING.html The generation of a mature peptide hormone by posttranslational processing of a prohormone. 18/44 Gene Ontology BP GO:0016486 4.83199923943902e-05 5.20085414321299e-05 3690 3740.90909090909 3689 4.39282306450907e-06 2911 1.66135435671583 -1.10519341432819 -1 7.56792011541715 3689 4245 2911 4144 4307 3795 3599 3299 4011 3485 3665 4060 M10274 GO_NUCLEAR_ENVELOPE_REASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_ENVELOPE_REASSEMBLY.html The reformation of the nuclear envelope following its breakdown in the context of a normal process. 23/24 Gene Ontology BP GO:0031468 7.5106867008031e-07 1.10452671361684e-06 3695 3390.09090909091 3691 6.82789933174008e-08 456 1.43212826265619 -0.828872277796707 -1 9.09375666434972 3691 4218 3517 4143 3133 3906 3779 2990 456 3894 3564 4061 M12154 GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism. 19/32 Gene Ontology BP GO:0048026 0.00096252995490687 0.000988228570207781 3210 3599.36363636364 3692 8.75410302720479e-05 2378 0.883293158917982 0.746552589910093 1 2.75163798931934 3206 4024 3692 2470 4524 2862 2378 3597 4600 4205 4035 4062 M13502 GO_PROTEIN_SUMOYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_SUMOYLATION.html The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. 132/158 Gene Ontology BP GO:0016925 4.96990577452799e-06 5.90525320962174e-06 330 2590.72727272727 3693 4.51810636529053e-07 218 1.42317875296463 1.51905991391872 1 7.91796262173576 326 3884 4038 3845 3889 636 218 2072 3693 4492 1405 4063 M15105 GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 238/306 Gene Ontology BP GO:0009123 1.9321295887724e-06 2.48760347995517e-06 2170 3696.45454545455 3695 1.75648298695397e-07 2168 1.31600390533116 -1.0924954420538 -1 7.84642214653535 2168 4641 4163 4320 3581 3103 2858 3665 3695 4509 3958 4064 M14112 GO_TRIGLYCERIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRIGLYCERIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. 10/25 Gene Ontology BP GO:0019433 2.57674095209824e-06 3.21867802687601e-06 4125 3415.90909090909 3696 2.34249451827312e-07 1451 2.86973112582272 -2.89670162973404 -1 16.8971971287231 4123 2560 1451 4089 3696 4566 3859 4616 3366 2083 3166 4065 M10834 GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MEMBRANE_INVAGINATION.html Any process that activates or increases the frequency, rate or extent of membrane invagination. 20/22 Gene Ontology BP GO:1905155 1.67716667442222e-07 3.52000745876706e-07 3700 3499.09090909091 3697 1.52469709298252e-08 2069 2.51794652824317 -1.76186138611381 -1 17.4238291185389 3697 4229 2069 4148 2171 3332 3026 3843 4319 3050 4606 4066 M14759 GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PHAGOCYTOSIS_ENGULFMENT.html Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. 20/22 Gene Ontology BP GO:0060100 1.67716667442222e-07 3.52000745876706e-07 3700 3501.81818181818 3698 1.52469709298252e-08 2070 2.51794652824317 -1.76186138611381 -1 17.4238291185389 3698 4230 2070 4149 2172 3333 3027 3857 4320 3057 4607 4067 M15678 GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SECONDARY_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. 12/16 Gene Ontology BP GO:0043455 8.93688181558324e-05 9.48308120590851e-05 4395 3597.72727272727 3698 8.12476806540233e-06 1628 2.081320942827 -1.32566364410588 -1 8.92358737061951 4393 3552 2633 3698 4372 4638 4197 2952 1628 3502 4010 4068 M14015 GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TUMOR_NECROSIS_FACTOR_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. 17/42 Gene Ontology BP GO:0042534 0.00218785108545298 0.00223345131650126 3685 3721.63636363636 3699 0.000199093626254287 1778 1.54137077231881 -1.74217744220253 -1 4.29686895125309 3682 4257 3126 4199 4546 4226 3620 1778 4373 3699 3432 4069 M11926 GO_INTRA_S_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRA_S_DNA_DAMAGE_CHECKPOINT.html A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. 11/13 Gene Ontology BP GO:0031573 1.28915060010818e-05 1.46555065872417e-05 2485 3336.63636363636 3701 1.17196195845745e-06 934 1.29076896992909 1.54858797722499 1 6.62084929244829 2483 4572 3701 4534 4071 2206 934 3128 4257 4029 2788 4070 M15284 GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCATION_IN_NUCLEUS.html Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. 13/15 Gene Ontology BP GO:0051457 2.71943010258396e-07 4.90636225952817e-07 1760 3179.54545454545 3701 2.4722094897582e-08 1199 0.729434911881262 -0.683276569669244 -1 4.85372007494195 1759 4054 3834 4552 2537 1846 1199 3701 4533 4134 2826 4071 M15486 GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. 50/71 Gene Ontology BP GO:0035914 2.63601933406058e-06 3.28831044541123e-06 4555 3350.72727272727 3701 2.39638408410862e-07 1390 2.62611016262501 -1.97386744333235 -1 15.4267924680159 4555 3061 1390 3095 3701 3943 3892 4473 2562 2009 4177 4072 M15970 GO_RESPONSE_TO_COBALT_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_COBALT_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. 17/17 Gene Ontology BP GO:0032025 5.83609311800342e-05 6.25699107789629e-05 4405 3639 3701 5.30567994714311e-06 2105 1.36786751333041 -0.93705285058893 -1 6.09249954061809 4405 3780 3342 3525 4324 4307 2441 2105 3484 3701 4615 4073 M16546 GO_RESPONSE_TO_MANGANESE_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MANGANESE_ION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. 25/30 Gene Ontology BP GO:0010042 2.63718431619482e-06 3.28888196817327e-06 4575 3485.36363636364 3702 2.39744316131462e-07 2014 1.88337062986944 1.57555523147938 1 11.0315108883282 4574 2406 2354 2014 3702 4577 4565 4359 2746 3306 3736 4074 M13028 GO_REGULATION_OF_HEXOKINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HEXOKINASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of hexokinase activity. 12/14 Gene Ontology BP GO:1903299 4.81046934629329e-05 5.17887872936203e-05 3575 3545.18181818182 3704 4.37324957648042e-06 2091 1.37734001288978 -1.74181163369606 -1 6.25755674706474 3574 4053 3279 3704 4305 4553 2740 2091 4007 3845 2846 4075 M15079 GO_PROTEIN_K63_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. 44/59 Gene Ontology BP GO:0070534 3.20334514538618e-06 3.92654503727131e-06 3445 3586.45454545455 3704 2.91213619061596e-07 2610 1.39040725156939 -1.78663529513113 -1 7.99897475570805 3441 3676 3707 4202 3768 4148 3704 3291 3069 3835 2610 4076 M16422 GO_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENE_SILENCING_BY_RNA.html Any process in which RNA molecules inactivate expression of target genes. 117/163 Gene Ontology BP GO:0031047 1.23609238564209e-06 1.68666799718259e-06 2390 3582.36363636364 3704 1.12372098195793e-07 2390 1.20286879441282 1.04937840378407 1 7.38122163392264 2390 4364 4135 4321 3375 2765 2887 2858 4084 4523 3704 4077 M16946 GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_METABOLIC_PROCESS.html Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. 33/50 Gene Ontology BP GO:0010907 4.24227556948862e-05 4.58414032160486e-05 3655 3703 3704 3.85668852345193e-06 2057 1.48943683543898 1.60202456948403 1 6.86120080825575 3654 3704 3467 3231 4289 3580 2057 4590 4156 4045 3960 4078 M14785 GO_REGULATION_OF_INTERLEUKIN_8_SECRETION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_SECRETION.html Any process that modulates the frequency, rate or extent of interleukin-8 secretion. 11/21 Gene Ontology BP GO:2000482 2.69935207086414e-06 3.36370786977258e-06 4535 3473.81818181818 3705 2.45395943901455e-07 1083 1.72692101440967 -1.96637266273983 -1 10.0875312045512 4531 1083 2481 3395 3705 4408 4441 4480 3090 2344 4254 4079 M14100 GO_REGULATION_OF_PROTEIN_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION.html Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. 1048/1431 Gene Ontology BP GO:0032880 5.23095800640415e-08 2.04020516377188e-07 3790 2946.81818181818 3706 5.2309581295373e-09 1022 1.91487155575151 2.00800097370589 1 13.7130611993237 3787 2103 4474 1022 1173 3904 3706 3859 2090 1805 4492 4080 M11959 GO_HEXOSE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEXOSE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. 54/78 Gene Ontology BP GO:0019320 2.24743338205571e-08 1.97691467186943e-07 3125 3387.72727272727 3707 2.043121277286e-09 187 1.73111359391429 -1.55691591690941 -1 12.4118222846757 3938 3371 2974 4519 187 4380 3817 3122 3122 3707 4128 4081 M10472 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. 15/16 Gene Ontology BP GO:0032211 0.000204515178308846 0.000213030921126273 845 2801.18181818182 3708 1.85940175281809e-05 70 1.15082541004881 1.24061850653645 1 4.44700229283737 842 4048 3708 3783 4513 921 70 2661 3896 4367 2004 4082 M12760 GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS.html Any process that modulates the occurrence or rate of thymocyte death by apoptotic process. 15/16 Gene Ontology BP GO:0070243 2.71258448146522e-06 3.37657988021874e-06 4505 3279 3708 2.46598893278956e-07 1340 2.37240446180413 -1.74298394454072 -1 13.89604516981 4502 2888 1604 2940 3708 4229 3769 4142 2825 1340 4122 4083 M15463 GO_RECIPROCAL_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_DNA_RECOMBINATION.html A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules. 30/42 Gene Ontology BP GO:0035825 4.13469611212014e-06 4.97382135721173e-06 710 2340.18181818182 3708 3.75882171174431e-07 134 1.14739900990398 1.25627627220457 1 6.45403929317135 710 3708 3742 4166 3841 414 134 435 4095 3728 769 4084 M14444 GO_REGULATION_OF_DEPHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DEPHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule. 171/217 Gene Ontology BP GO:0035303 5.85365147070135e-08 2.0762333639785e-07 4645 3396.09090909091 3709 5.32150147859313e-09 1196 1.73579488515621 -1.40759647920405 -1 12.4058124903497 4641 3006 3358 2593 1196 4005 4094 3963 2762 3709 4030 4085 M15870 GO_CELLULAR_MACROMOLECULE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULE_LOCALIZATION.html Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. 1320/1626 Gene Ontology BP GO:0070727 4.00974355153983e-08 1.97691467186943e-07 3850 3395.63636363636 3709 4.00974362389102e-09 849 1.64805333742276 -1.43797486850164 -1 11.8108663054819 3848 3851 4578 3785 849 2927 3709 3652 2183 4525 3445 4086 M16397 GO_RECIPROCAL_MEIOTIC_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECIPROCAL_MEIOTIC_RECOMBINATION.html The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. 30/42 Gene Ontology BP GO:0007131 4.13469611212014e-06 4.97382135721173e-06 715 2385.18181818182 3709 3.75882171174431e-07 135 1.14739900990398 1.25627627220457 1 6.45403929317135 711 3709 3743 4167 3842 415 135 920 4096 3729 770 4087 M12495 GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION.html Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. 1776/2298 Gene Ontology BP GO:0044093 4.20111323414696e-08 1.97691467186943e-07 3865 2880.18181818182 3710 4.20111331356905e-09 550 1.94904985450405 2.12483573260393 1 13.9886305491426 3861 2092 4371 1108 932 3743 3710 4067 2603 550 4645 4088 M10521 GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 30/37 Gene Ontology BP GO:0006221 1.00157320563298e-06 1.40667676601577e-06 3110 3571.72727272727 3711 9.1052151055458e-08 2375 1.09233967640317 1.22135587401011 1 6.78552210780417 3108 2375 3726 3943 3275 3827 4563 3711 3296 3538 3927 4089 M12493 GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE_TO_VIRUS.html Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. 21/27 Gene Ontology BP GO:0050687 2.47949037369283e-07 4.58548040890014e-07 4425 3543.72727272727 3712 2.25408241194694e-08 2375 1.79649187156779 2.27619647396017 1 12.1764032303217 4424 4227 3251 3712 2472 3812 2375 3430 3991 3184 4103 4090 M13169 GO_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium. 52/89 Gene Ontology BP GO:0003341 1.96193055784837e-07 3.92510651315787e-07 4515 3554.09090909091 3713 1.7835733934643e-08 2286 1.94902432944549 -1.81933569065503 -1 13.3619053188073 4512 3914 2456 3976 2286 4420 4544 2965 3085 3224 3713 4091 M15179 GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_FATTY_ACID_BIOSYNTHETIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids. 17/18 Gene Ontology BP GO:0045717 2.18165664022267e-07 4.19624379491385e-07 3480 3603.90909090909 3713 1.98332441506302e-08 2377 0.947985762998185 -0.846212031368832 -1 6.41132851329497 3479 3762 3713 3724 2377 3444 4175 3463 4390 4122 2994 4092 M14826 GO_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOR_SIGNALING.html A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. 20/20 Gene Ontology BP GO:0031929 0.00101171073326197 0.00103849328080034 4525 3500 3714 9.20160260848228e-05 2010 1.22269470098485 -1.18976203529967 -1 3.82396832540573 2010 4525 3714 4538 4525 2470 2379 3383 4160 4356 2440 4093 M10127 GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_DEPOLARIZATION.html Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. 20/22 Gene Ontology BP GO:0051900 1.79342403538033e-06 2.32640145988979e-06 4025 3405.45454545455 3716 1.63038681578932e-07 1511 2.612370204123 2.6550767489884 1 15.7692020958286 3716 2459 1511 3908 3556 4022 4488 3252 4021 2244 4283 4094 M14637 GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBOSE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose. 22/25 Gene Ontology BP GO:0046386 5.08849790634636e-05 5.4706055356353e-05 2290 3565.09090909091 3716 4.62601418613891e-06 2141 1.23621542177622 -1.16310486666433 -1 5.57305608659024 2290 4495 3584 4405 4312 2726 2141 3716 3938 4160 3449 4095 M10194 GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon-beta production. 62/97 Gene Ontology BP GO:0032648 2.72827742476179e-06 3.39248392769017e-06 3955 3571.90909090909 3718 2.48025528015974e-07 2121 1.50917173700663 -1.41322326915723 -1 8.7952976471194 3955 3902 3493 4029 3712 4211 3778 2121 3718 3320 3052 4096 M10548 GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOTIDE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 26/33 Gene Ontology BP GO:0009261 3.89863289911726e-06 4.70566507901235e-06 4405 3495.63636363636 3719 3.54421800720419e-07 2045 1.94358958999272 -1.79344510735915 -1 11.0615222871783 4402 3719 2651 3630 3826 4268 4188 2315 3377 2045 4031 4097 M10572 GO_PROTEIN_HOMOTETRAMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_HOMOTETRAMERIZATION.html The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. 72/87 Gene Ontology BP GO:0051289 2.21717586995874e-08 1.97691467186943e-07 3870 3014.72727272727 3719 2.01561444754872e-09 178 1.73620669096333 -1.27279487620905 -1 12.4486717630367 3867 252 2962 3639 178 4194 4484 4256 1429 3719 4182 4098 M10574 GO_IMMUNE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMMUNE_SYSTEM_PROCESS.html Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. 1774/2967 Gene Ontology BP GO:0002376 5.66777313678512e-10 1.10807346241433e-08 4215 2970.54545454545 3719 5.66777313823067e-11 110 2.12068723905569 -1.98137486843627 -1 18.094597137058 4213 1136 4247 2687 1111 4065 4413 4405 2570 110 3719 4099 M12405 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_PERMEABILITY.html Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. 22/23 Gene Ontology BP GO:0035794 2.92770165368384e-06 3.61246242232588e-06 3745 3731.54545454545 3719 2.6615504998171e-07 3089 1.16181370491774 -1.16093075725088 -1 6.71068726614249 3327 3744 3716 4424 3742 3343 3719 3089 4143 4158 3642 4100 M15375 GO_PROTEIN_K63_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K63_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. 25/32 Gene Ontology BP GO:0070536 0.00216650341659592 0.00221262958679122 3200 3435.90909090909 3720 0.000197149079956976 1342 1.22573435796001 -0.900609830040591 -1 3.39919275900422 3200 4493 3720 4562 4612 3267 3983 1676 1342 4362 2578 4101 M13366 GO_MULTICELLULAR_ORGANISM_GROWTH http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTICELLULAR_ORGANISM_GROWTH.html The increase in size or mass of an entire multicellular organism, as opposed to cell growth. 100/121 Gene Ontology BP GO:0035264 2.82463322829664e-08 1.97691467186943e-07 4260 3347.27272727273 3721 2.56784842232981e-09 360 1.63808390696443 1.72825081785495 1 11.7387356729006 4260 3351 3416 3721 360 4595 4198 2292 2569 3779 4279 4102 M13501 GO_POSITIVE_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_BONE_RESORPTION.html Any process that activates or increases the frequency, rate or extent of bone resorption. 11/15 Gene Ontology BP GO:0045780 1.25875705250199e-06 1.7145774488559e-06 3725 3250.63636363636 3721 1.14432524792354e-07 1307 2.28837384578456 -2.78329637933708 -1 14.126718556222 3921 2052 1650 3097 3381 4282 4247 3721 4376 1307 3723 4103 M11304 GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. 70/82 Gene Ontology BP GO:0033143 1.64376281900504e-05 1.8447728887676e-05 4480 3534.81818181818 3722 1.49434100068421e-06 936 1.74226967229917 -1.64875240271906 -1 8.78840798995121 4476 3897 3718 3233 4123 3956 3722 3301 936 4327 3194 4104 M14771 GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY.html A series of molecular signals mediated by a steroid hormone binding to a receptor. 122/224 Gene Ontology BP GO:0043401 3.67764741550386e-07 6.24090805343792e-07 4105 3709.54545454545 3722 3.3433163911644e-08 2708 1.79336669391389 1.77149577559718 1 11.8959383379244 4105 3624 3345 2882 2708 4449 4430 4175 2779 3722 4586 4105 M15043 GO_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. 630/813 Gene Ontology BP GO:0016071 2.53314255122946e-06 3.17527003286833e-06 1755 3639.36363636364 3722 2.53314543879912e-07 1754 1.03042038910557 1.01696891183467 1 6.00126377761125 1754 4611 4533 4651 3722 2781 1849 3660 4225 4640 3607 4106 M14499 GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 142/172 Gene Ontology BP GO:0044262 1.99879008283407e-08 1.97691467186943e-07 3725 3374.63636363636 3723 1.81708190999446e-09 124 1.34880505891432 -1.2577189203448 -1 9.64575088410726 3723 3335 3831 4134 124 3484 4245 3164 2887 4266 3928 4107 M14846 GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHEMOKINE_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. 14/22 Gene Ontology BP GO:0032682 0.000691174820777146 0.000711040557390241 3710 3644.18181818182 3723 6.28538239078138e-05 1540 1.79045706778148 -2.60029850836721 -1 5.97004232581246 3707 4560 3276 3723 4515 4424 4269 1997 4363 3712 1540 4108 M15947 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS.html Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus. 33/37 Gene Ontology BP GO:1901522 3.83290698586486e-07 6.42453753790677e-07 4005 3614.09090909091 3724 3.48446150331432e-08 2582 1.44313089733925 1.73094233274336 1 9.53101704600236 4004 3693 3506 2991 2742 3821 3908 4229 2582 3724 4555 4109 M16658 GO_LOCOMOTORY_EXPLORATION_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_LOCOMOTORY_EXPLORATION_BEHAVIOR.html The specific movement from place to place of an organism in response to a novel environment. 18/24 Gene Ontology BP GO:0035641 7.31732428830042e-06 8.52679937727569e-06 3610 3406.63636363636 3726 6.65213511477065e-07 1897 2.06174710306383 2.73386101601655 1 11.1664223424174 3607 2859 2270 3950 3966 3726 3447 3780 4087 1897 3884 4110 M15946 GO_RESPONSE_TO_ETHER http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ETHER.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. 11/17 Gene Ontology BP GO:0045472 0.000117866342060263 0.000124135828340064 2640 3298.45454545455 3727 1.07156961177386e-05 1700 2.09686924748598 2.62184632230829 1 8.72644159600028 2636 3830 2723 3727 4403 2546 1700 4156 3909 2904 3749 4111 M11965 GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response. 20/22 Gene Ontology BP GO:1903894 5.88856839303674e-06 6.94185678560932e-06 3265 3672.45454545455 3729 5.35325832233408e-07 3073 0.844215730556538 0.807372815772936 1 4.58685548051872 3262 3753 3710 3809 3920 3300 3146 3073 4611 4084 3729 4112 M12089 GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_MORPHOGENESIS_OF_AN_ENDOTHELIUM.html The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. 23/25 Gene Ontology BP GO:0003159 4.58119530482216e-06 5.46571839829167e-06 4155 3263.36363636364 3730 4.16473167686792e-07 597 2.01045770491171 -1.62347722667267 -1 11.30488821654 4155 3730 2717 1804 3874 4289 3886 3941 597 3410 3494 4113 M12274 GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC.html Any epigenetic process that stops, prevents or reduces the rate of gene expression. 75/125 Gene Ontology BP GO:0045814 1.41770121705821e-06 1.89610915865819e-06 3445 3620.63636363636 3730 1.28882011876307e-07 2296 1.37176141428688 1.24921805833974 1 8.35822867881598 3444 3644 3741 3563 3449 3730 4139 2296 3920 4024 3877 4114 M11368 GO_POSTREPLICATION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTREPLICATION_REPAIR.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. 60/72 Gene Ontology BP GO:0006301 1.95122952605153e-06 2.50872367635197e-06 2950 3494.54545454545 3731 1.77384659694824e-07 2461 1.26681441010027 1.28424908380108 1 7.54389195193912 2947 3903 3803 3756 3585 2580 2461 3471 3731 4210 3993 4115 M13491 GO_REGULATION_OF_CENTROSOME_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CENTROSOME_CYCLE.html Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. 47/54 Gene Ontology BP GO:0046605 2.11302149524752e-06 2.70032656341299e-06 3825 3703.54545454545 3731 1.92093047702908e-07 3068 1.04900646036022 1.17258846781955 1 6.19121173570227 3824 3068 3857 3516 3609 3731 3356 3760 4211 3268 4539 4116 M12355 GO_ATRIAL_SEPTUM_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATRIAL_SEPTUM_DEVELOPMENT.html The progression of the atrial septum over time, from its initial formation to the mature structure. 19/26 Gene Ontology BP GO:0003283 2.83783487042997e-06 3.51275489548036e-06 4225 3387.45454545455 3732 2.57985321002778e-07 560 1.80078325046409 1.78769658176718 1 10.487228311948 4223 3490 3144 1662 3732 3760 3608 4529 560 4206 4348 4117 M12834 GO_FEAR_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_FEAR_RESPONSE.html The response of an organism to a perceived external threat. 23/47 Gene Ontology BP GO:0042596 1.33040839077554e-05 1.50874731715296e-05 4510 3500.09090909091 3734 1.20946948748797e-06 1757 2.26705002810307 -2.36501655695566 -1 11.6832451319579 4509 3734 2361 3115 4081 4644 4570 1886 1757 3411 4433 4118 M13360 GO_MITOCHONDRIAL_RNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_PROCESSING.html The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. 12/12 Gene Ontology BP GO:0000963 2.57863612651772e-06 3.22018086330837e-06 3775 3921.45454545455 3734 2.34421740814635e-07 3253 0.722043542105897 -0.770235893223025 -1 4.16664826880754 3772 3253 3688 3734 3697 3663 3433 4623 4513 4629 4131 4119 M14367 GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO__DE_NOVO_POSTTRANSLATIONAL_PROTEIN_FOLDING.html The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. 27/28 Gene Ontology BP GO:0051084 1.50194165482489e-06 1.99444478307655e-06 3735 3857.81818181818 3735 1.36540243654779e-07 2866 1.15144205466889 1.30244066533769 1 6.97035681608794 3504 4214 3735 3810 3472 4299 4648 2866 4606 3733 3549 4120 M10053 GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NLRP3_INFLAMMASOME_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly. 15/25 Gene Ontology BP GO:1900225 2.88771368962546e-06 3.56785230956646e-06 2650 3610.54545454545 3737 2.62519770912466e-07 2425 1.4245838395839 -1.560969722542 -1 8.2623355694652 2647 4265 3253 3784 3737 3582 4410 3292 4511 3810 2425 4121 M15427 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. 23/30 Gene Ontology BP GO:0071354 0.000499202559467951 0.000514916761073903 3670 3902.81818181818 3737 4.53923517859128e-05 3412 1.40509579137483 -1.0774672716323 -1 4.87330192570383 3670 3737 3418 3528 4498 4338 4240 3461 4272 3412 4357 4122 M11124 GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION.html Any process that activates or increases the frequency, rate or extent of viral genome replication. 37/50 Gene Ontology BP GO:0045070 1.11748664994291e-06 1.54659886442128e-06 4255 3869.90909090909 3738 1.01589747051723e-07 3329 1.03697967215993 -1.20359046705792 -1 6.38980860260293 4252 3690 3873 4228 3329 4511 3718 3372 3738 4265 3593 4123 M13503 GO_MEGAKARYOCYTE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DEVELOPMENT.html The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. 19/21 Gene Ontology BP GO:0035855 2.83280253777921e-06 3.50932646652999e-06 3815 3493.27272727273 3739 2.57527835037146e-07 1806 1.66450361949999 -1.81396642441216 -1 9.6857789031649 3811 4011 3048 3739 3729 4030 4588 1851 4203 3610 1806 4124 M10128 GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY.html Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. 88/111 Gene Ontology BP GO:0043407 7.59087554149481e-08 2.29469567498056e-07 4435 3021.18181818182 3741 6.90079618491842e-09 154 1.7338272793245 1.94647319553878 1 12.3103200287632 4431 154 2491 4116 1445 4134 4059 3741 2488 2048 4126 4125 M12040 GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ENDOPLASMIC_RETICULUM.html A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. 152/246 Gene Ontology BP GO:0070972 2.58212587806653e-05 2.83966714976213e-05 2475 3674.90909090909 3741 2.34741471346382e-06 2471 0.983821104696679 -0.687553241519312 -1 4.71448976569552 2471 4361 4199 2683 4208 2886 3253 3548 4480 4594 3741 4126 M12198 GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. 30/38 Gene Ontology BP GO:0044275 1.59314908695942e-05 1.79142646245099e-05 2075 3166 3742 1.44832784000338e-06 1447 1.10815025571027 1.15945116965158 1 5.56384203290102 2072 3962 3807 3742 4114 2217 1447 2630 3978 4055 2802 4127 M14974 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. 11/20 Gene Ontology BP GO:0032691 0.0241943026015189 0.0244571127536102 3700 3725.09090909091 3743 0.00222404975752169 2395 1.50545025743389 0.984711846693615 1 2.50530764818066 3699 4577 3365 3754 4590 3290 2395 3349 4056 3743 4158 4128 M15933 GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DOUBLE_STRAND_BREAK_PROCESSING.html The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. 20/23 Gene Ontology BP GO:0000729 1.57882261407872e-05 1.77617544083856e-05 1265 2740.45454545455 3746 1.43530358596368e-06 963 1.17298665027152 1.38057289215279 1 5.90069274334305 1265 4013 3792 3746 4112 1091 963 1636 3902 4087 1538 4129 M11870 GO_GABAERGIC_NEURON_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GABAERGIC_NEURON_DIFFERENTIATION.html The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. 6/21 Gene Ontology BP GO:0097154 2.70634998946441e-06 3.36972076558146e-06 4345 3253.72727272727 3748 2.70635328541868e-07 602 3.1447933625294 -1.18374603052964 -1 18.4600296505627 4342 2961 4330 2127 3748 4480 4387 2438 602 2165 4211 4130 M12553 GO_EPITHELIAL_CILIUM_MOVEMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_EPITHELIAL_CILIUM_MOVEMENT.html The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. 38/60 Gene Ontology BP GO:0003351 2.98279690004786e-06 3.6738757451416e-06 4340 3692.54545454545 3749 2.71163722198327e-07 2849 1.71444099646271 1.91684595206191 1 9.94293672796533 4336 3943 2849 4206 3749 4003 3743 2961 3721 3220 3887 4131 M13570 GO_TRNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METHYLATION.html The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. 23/23 Gene Ontology BP GO:0030488 3.10212023516403e-05 3.38432953205585e-05 2885 3564.54545454545 3749 2.82014907056203e-06 2034 0.792704923184462 0.848027113843632 1 3.71149259872132 2884 3749 3949 4024 4243 2913 2034 2871 4426 4409 3708 4132 M16339 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 48/52 Gene Ontology BP GO:0070059 1.8498925149962e-07 3.77524117205145e-07 4000 3765.36363636364 3749 1.68172060958756e-08 2237 1.31861806287521 -1.19752573307559 -1 9.02751457063285 3997 4428 3749 4263 2237 3703 3303 3641 4351 3327 4420 4133 M12020 GO_HISTONE_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MONOUBIQUITINATION.html The modification of histones by addition of a single ubiquitin group. 25/26 Gene Ontology BP GO:0010390 2.98300076620352e-06 3.6738757451416e-06 3170 3669.81818181818 3750 2.71182255535463e-07 2555 0.864842054470193 0.821639613806078 1 4.95962367575072 3168 3728 3965 3776 3750 3567 3574 2555 4031 4260 3994 4134 M13181 GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_ARSENIC_CONTAINING_SUBSTANCE.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. 20/22 Gene Ontology BP GO:0071243 0.000162567318158755 0.000169906947752176 3875 3853.54545454545 3750 1.47799392899404e-05 3323 0.963952078032064 -1.04825609395429 -1 3.80871706873221 3871 3750 3648 4181 4440 3658 3737 3323 4333 3918 3530 4135 M13358 GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. 1798/2297 Gene Ontology BP GO:0006796 4.46720059074689e-08 1.97691467186943e-07 3755 3446.90909090909 3751 4.46720068054835e-09 989 1.73838697622259 -1.57837136037299 -1 12.4644465212453 3751 3847 4423 4377 989 2987 3424 3883 2764 4006 3465 4136 M11674 GO_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_REPAIR.html Any process that modulates the frequency, rate or extent of DNA repair. 90/109 Gene Ontology BP GO:0006282 4.83596032744525e-07 7.69552783980943e-07 3755 3658.90909090909 3753 4.39632853678987e-08 2570 1.45025843183474 1.49262430905127 1 9.45594524413001 3753 4127 3658 4249 2891 3372 2570 4345 3323 3852 4108 4137 M14640 GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving glycosyl compound. 348/462 Gene Ontology BP GO:1901657 1.22925199309624e-07 2.88874218377617e-07 2350 3463.27272727273 3753 1.11750187434619e-08 1919 1.51456473909976 -1.32208083417415 -1 10.5758050456885 2348 4327 4118 4061 1919 3013 2933 3753 3363 4463 3798 4138 M14172 GO_ZINC_II_ION_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_II_ION_TRANSPORT.html The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/27 Gene Ontology BP GO:0006829 1.28454055394656e-06 1.74154777010421e-06 3790 3645.27272727273 3754 1.16776482178852e-07 1859 1.24596673483662 -1.22314619194813 -1 7.63103888453234 3786 3754 3563 4509 3396 2897 1859 4543 4300 3683 3808 4139 M10289 GO_NCRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). 21/26 Gene Ontology BP GO:0034661 1.63901592299257e-06 2.15311719076353e-06 3485 3677 3755 1.49001558552051e-07 1446 1.11999349104547 -1.08956292776784 -1 6.73670608984163 3482 4509 3825 4548 3511 2838 1446 4432 4353 3755 3748 4140 M13470 GO_PROTEIN_MONOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MONOUBIQUITINATION.html Addition of a single ubiquitin group to a protein. 60/65 Gene Ontology BP GO:0006513 3.64581364841836e-06 4.42461421650773e-06 3185 3711.90909090909 3756 3.31438153657371e-07 3131 1.12206211991433 1.22041496457759 1 6.37055852991093 3182 3660 4058 3825 3807 3131 3464 3814 3756 4425 3709 4141 M13789 GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_AMINO_ACID_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. 26/27 Gene Ontology BP GO:0034198 2.18855888677946e-05 2.42518802100138e-05 3570 3418.18181818182 3758 1.98961878077765e-06 1771 1.19927567037439 -0.875480626705648 -1 5.8604081294277 3566 4205 3758 3957 4178 2924 1771 3020 3843 4289 2089 4142 M11143 GO_POSITIVE_REGULATION_OF_COAGULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_COAGULATION.html Any process that activates or increases the frequency, rate or extent of coagulation. 24/46 Gene Ontology BP GO:0050820 3.11502495335516e-06 3.82612468145234e-06 3945 3429.18181818182 3759 2.8318448763558e-07 1404 2.5889326929963 -2.19651420557414 -1 15.0229857112284 3943 3443 1404 2387 3759 4185 4602 3774 4136 2508 3580 4143 M13753 GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GLYCOGEN_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. 34/48 Gene Ontology BP GO:0070873 6.3651707408838e-07 9.6065972939774e-07 3925 3627.54545454545 3759 5.78652052953961e-08 2795 1.64068314257891 2.17313398731625 1 10.5418273281907 3923 3703 3078 3759 3045 4606 4179 3168 3850 3797 2795 4144 M10557 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. 13/24 Gene Ontology BP GO:0032692 0.16269410626435 0.163572963796029 2990 3632.72727272727 3760 0.0160127569934064 1751 1.52709051215139 1.11915588544617 1 1.18277189796491 2986 4055 3389 3760 4639 3041 1751 4603 4104 3636 3996 4145 M12650 GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_TRANSLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. 11/11 Gene Ontology BP GO:0070129 0.000154156791203704 0.000161225342654717 2645 3592.72727272727 3760 1.4015235838676e-05 2403 0.741502111801804 -0.80461837113658 -1 2.92191299728242 2641 4067 3760 4204 4436 2867 2403 2737 4556 4255 3594 4146 M11076 GO_MACROMOLECULE_DEACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_DEACYLATION.html The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. 66/70 Gene Ontology BP GO:0098732 3.84216724287548e-07 6.43542267138215e-07 4245 3682.90909090909 3761 3.49287992171543e-08 2743 1.30933149545366 -1.24540945826427 -1 8.63582725418439 4242 3650 3995 3761 2743 4162 4128 3023 3564 4116 3128 4147 M16317 GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CONTAINING_RIBONUCLEOPROTEIN_COMPLEX_EXPORT_FROM_NUCLEUS.html The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. 11/16 Gene Ontology BP GO:0071428 0.000180902117114773 0.000188645798058054 3200 3655.27272727273 3762 1.64469994626581e-05 2213 0.79709049952515 0.835864081074409 1 3.09075884211005 3196 3834 3715 3762 4449 3307 2213 2936 4453 4258 4085 4148 M16454 GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 138/204 Gene Ontology BP GO:0032479 2.08502725025458e-06 2.66748193440598e-06 2800 3471.63636363636 3762 1.89548111483655e-07 1753 1.50820554701177 -1.43606006874161 -1 8.95955311901714 2798 4350 3923 4300 3605 2751 3762 1753 4172 4105 2669 4149 M10051 GO_GLUCURONATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCURONATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. 9/28 Gene Ontology BP GO:0019585 2.85115180630134e-06 3.52548747135799e-06 3875 2879.54545454545 3763 2.85115546438792e-07 6 3.18159248851385 -1.87229566799671 -1 18.6099782630612 3872 1077 4220 196 3763 4000 4445 3298 6 2423 4375 4150 M11565 GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 59/95 Gene Ontology BP GO:0051196 2.50214926989833e-08 1.97691467186943e-07 3905 3472.27272727273 3764 2.27468118032389e-09 261 1.59382105594307 -1.18832436348985 -1 11.4184859397425 3764 3905 3371 3771 261 4295 3723 3905 3348 3524 4328 4151 M14675 GO_URONIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URONIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. 9/28 Gene Ontology BP GO:0006063 2.85115180630134e-06 3.52548747135799e-06 3875 2910.36363636364 3764 2.85115546438792e-07 7 3.18159248851385 -1.87229566799671 -1 18.6099782630612 3873 1078 4510 197 3764 4001 4446 3327 7 2435 4376 4152 M15443 GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 59/95 Gene Ontology BP GO:0051193 2.50214926989833e-08 1.97691467186943e-07 3765 3478.27272727273 3765 2.27468118032389e-09 262 1.59382105594307 -1.18832436348985 -1 11.4184859397425 3765 3906 3372 3772 262 4296 3724 3961 3349 3525 4329 4153 M15461 GO_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RECOMBINATIONAL_REPAIR.html A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA. 76/92 Gene Ontology BP GO:0000725 1.66470083693396e-05 1.86782083295243e-05 505 2672.09090909091 3766 1.513375848693e-06 300 1.21404313034241 1.21202457190467 1 6.08255763457313 503 3896 4033 3802 4124 771 300 1757 4052 3766 2389 4154 M15253 GO_VIRAL_LATENCY http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LATENCY.html The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. 13/16 Gene Ontology BP GO:0019042 6.34850123266458e-05 6.79695725623293e-05 2025 3444.90909090909 3770 5.77153130695217e-06 1740 0.750783778963924 0.686840287710808 1 3.26385068733439 2025 4284 3770 4539 4335 2276 1740 3015 4607 4319 2984 4155 M11474 GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 17/18 Gene Ontology BP GO:0051571 1.60203360113429e-06 2.11049330296655e-06 4570 3650.63636363636 3771 1.45639524339244e-07 1518 1.08329705545715 -1.16987147952486 -1 6.52242554131336 4570 3771 3532 3196 3497 4044 3879 4625 1518 4118 3407 4156 M11365 GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 46/67 Gene Ontology BP GO:0032480 5.6534271008925e-06 6.67988732870818e-06 1570 2742.81818181818 3772 5.1394923898002e-07 925 1.39233463197086 -1.19451031690367 -1 7.66347004174918 1569 4439 3778 4433 3911 971 1087 1311 3975 3772 925 4157 M12839 GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. 22/25 Gene Ontology BP GO:0060716 8.9674666111493e-05 9.51336574137658e-05 3040 3847.27272727273 3772 8.15257468801459e-06 3040 0.998726876741344 -1.04828743297857 -1 4.22168491160244 3040 4001 3772 3569 4373 3283 3683 4222 4538 4159 3680 4158 M14734 GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 17/18 Gene Ontology BP GO:0009219 2.60532775417909e-05 2.86450615316525e-05 4560 3849.81818181818 3772 2.36850782547374e-06 2787 1.395515904006 1.19754190623622 1 6.7289701436939 4558 3772 3275 4376 4209 4473 3526 3502 2787 3387 4483 4159 M13861 GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of an immune response to tumor cell. 4/16 Gene Ontology BP GO:0002837 6.2363006634218e-06 7.32025907843129e-06 3195 3696.45454545455 3776 6.2363181646416e-07 2655 0.925088086350116 0.721048658222923 1 5.01407788943594 3193 3287 4455 3679 3952 2932 2655 4215 4342 3776 4175 4160 M15037 GO_ORGANELLE_INHERITANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANELLE_INHERITANCE.html The partitioning of organelles between daughter cells at cell division. 16/16 Gene Ontology BP GO:0048308 1.91328621855758e-05 2.13387362774411e-05 4085 3641.18181818182 3776 1.73936623467517e-06 2015 1.25583667652067 1.55069491303056 1 6.21745969544955 4084 4035 3776 3537 4152 4634 3707 2015 3188 4076 2849 4161 M16191 GO_PEPTIDYL_LYSINE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_METHYLATION.html The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. 75/84 Gene Ontology BP GO:0018022 3.73633726098121e-06 4.52503312736741e-06 2445 3497.09090909091 3776 3.39667600595371e-07 2250 1.56493425342219 -1.66085957232563 -1 8.9131633362868 2443 4403 3898 4592 3815 2940 2947 2250 3776 4348 3056 4162 M16192 GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that modulates the frequency, rate, or extent of a response to tumor cell. 4/16 Gene Ontology BP GO:0002834 6.2363006634218e-06 7.32025907843129e-06 3195 3708.45454545455 3777 6.2363181646416e-07 2656 0.925088086350116 0.721048658222923 1 5.01407788943594 3194 3288 4602 3680 3953 2933 2656 4191 4343 3777 4176 4163 M13986 GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. 52/88 Gene Ontology BP GO:0043471 2.63501844920258e-08 1.97691467186943e-07 3615 3386.36363636364 3778 2.3954713461483e-09 296 1.51430731526547 -1.0545151563928 -1 10.8431896439364 3611 4153 3245 3789 296 3966 3358 3913 3235 3906 3778 4164 M10217 GO_REGULATION_OF_DNA_RECOMBINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_RECOMBINATION.html Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. 57/91 Gene Ontology BP GO:0000018 6.45148376908488e-06 7.56139898678891e-06 1670 3008 3779 5.86500244371919e-07 1521 1.2867519419131 1.38373747148278 1 6.99900390863628 1667 3910 3897 3779 3942 1935 1521 2152 3794 3864 2627 4165 M13851 GO_METHIONINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHIONINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. 18/21 Gene Ontology BP GO:0006555 1.19456464764945e-07 2.84781310169492e-07 3030 3551.27272727273 3779 1.08596792046582e-08 1890 1.01768410402745 1.25836651602681 1 7.07592180838641 3029 3194 3779 4170 1890 4413 4038 3104 3965 3789 3693 4166 M16356 GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. 52/88 Gene Ontology BP GO:0043470 2.63501844920258e-08 1.97691467186943e-07 3615 3395.81818181818 3779 2.3954713461483e-09 297 1.51430731526547 -1.0545151563928 -1 10.8431896439364 3612 4154 3246 3790 297 3967 3359 4006 3236 3908 3779 4167 M10766 GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DEGRANULATION.html Any process that activates or increases the frequency, rate or extent of leukocyte degranulation. 15/21 Gene Ontology BP GO:0043302 1.54626216788216e-06 2.04280461872677e-06 4540 3624.18181818182 3780 1.40569386788008e-07 2183 2.30805686761004 -2.26351531246214 -1 14.0597155091919 4538 4043 2779 2183 3489 4445 4303 3055 3780 3469 3782 4168 M14652 GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_PORE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. 12/12 Gene Ontology BP GO:0051292 0.00507865868771607 0.00516524565550664 2015 3574.90909090909 3780 0.000462765518807849 2012 0.778616869111744 0.709859559668884 1 1.80860988740858 2012 3828 3780 4006 4560 3136 2868 3075 4526 4081 3452 4169 M15235 GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides. 18/22 Gene Ontology BP GO:0030812 0.000156138784124487 0.000163261519669941 4210 3663.18181818182 3780 1.41954424304301e-05 1809 1.08964630579162 -0.986741132102011 -1 4.34047744118672 4209 3498 3570 3780 4438 3705 2663 4214 4244 4165 1809 4170 M12728 GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NIK_NF_KAPPAB_SIGNALING.html Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling. 34/51 Gene Ontology BP GO:1901224 1.87051353290457e-06 2.41495545743756e-06 4175 3817.18181818182 3781 1.70046829389054e-07 3202 1.67238619700255 -1.68098181047795 -1 10.0251437508845 4173 3951 3220 3202 3572 4389 4437 4652 3263 3349 3781 4171 M13992 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 19/23 Gene Ontology BP GO:0009147 4.50822221106496e-06 5.39109687691731e-06 4180 3697.54545454545 3782 4.09839222663996e-07 1978 0.948975383379922 -0.775376786042071 -1 5.28252950264589 4178 1978 3706 3945 3865 3715 3475 3919 3782 3612 4498 4172 M14424 GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing. 27/29 Gene Ontology BP GO:0031442 3.92003222627714e-05 4.24381338968533e-05 2810 3322.72727272727 3783 3.56372916040069e-06 1462 1.28318405312327 1.55352338043161 1 5.94181551232553 2808 4210 3783 4441 4278 2516 2005 2608 4134 4305 1462 4173 M14563 GO_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRION_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. 653/787 Gene Ontology BP GO:0007005 1.71733823731344e-07 3.58302323003767e-07 3115 3851.90909090909 3784 1.71733837002974e-08 2256 1.49505410354171 -1.33790406501136 -1 10.2871814815807 3114 4608 4501 4638 2256 3552 3639 4069 3612 4598 3784 4174 M12876 GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-8 production. 66/109 Gene Ontology BP GO:0032677 3.37697176733579e-07 5.80245555148206e-07 3785 3566.27272727273 3785 3.06997480517885e-08 2607 1.80394206314732 1.78935351361818 1 12.0283459976383 3785 4146 2618 4039 2666 3396 3272 3997 4051 2607 4652 4175 M13289 GO_PROTEIN_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MANNOSYLATION.html The addition of a mannose residue to a protein acceptor molecule. 20/21 Gene Ontology BP GO:0035268 1.17684158945141e-07 2.82410554926575e-07 4450 3587.54545454545 3785 1.06985604763997e-08 1878 1.03589735974728 1.23736719299627 1 7.20864088587528 4446 4228 3785 4401 1878 3544 2836 2742 3840 4234 3529 4176 M11505 GO_HISTONE_H2A_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_UBIQUITINATION.html The modification of histone H2A by addition of one or more ubiquitin groups. 20/20 Gene Ontology BP GO:0033522 1.21830279516192e-05 1.3883818040383e-05 2945 3464.72727272727 3786 1.10755412896211e-06 1909 0.660434907618811 0.688614354143709 1 3.34913807427276 2945 4005 3972 3786 4062 2975 2483 1909 4307 4450 3218 4177 M11819 GO_REGULATION_OF_CHROMATIN_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CHROMATIN_BINDING.html Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. 25/33 Gene Ontology BP GO:0035561 0.000236747237595114 0.000246109226213152 2215 3246.36363636364 3791 2.15247925789027e-05 862 1.07127550789265 1.37191685486901 1 4.05931514739533 2212 4217 3791 4417 4463 2082 862 3508 4226 4361 1571 4178 M11109 GO_IMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving IMP, inosine monophosphate. 13/14 Gene Ontology BP GO:0046040 0.00013315060044136 0.000139727050936772 4465 3560.90909090909 3792 1.21053327089157e-05 1916 1.1497557276002 -0.978933903537773 -1 4.67004094698492 4464 3819 3634 2983 4421 3706 1916 2636 3876 3923 3792 4179 M16622 GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_METABOLIC_COMPOUND_SALVAGE.html Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. 33/40 Gene Ontology BP GO:0043094 5.49864128658554e-08 2.05617623085131e-07 4140 3598.36363636364 3793 4.99876493092509e-09 1119 1.33577873998093 1.52155368193167 1 9.52689127744886 4137 3424 3454 4512 1119 4551 4018 3793 2976 3274 4324 4180 M14299 GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. 16/22 Gene Ontology BP GO:0006577 1.58646509509599e-06 2.09116773016477e-06 3800 3526.72727272727 3795 1.4422420355724e-07 2244 0.958442206010099 -1.08626649203552 -1 5.76178416338339 3798 2900 3565 3986 3495 2453 2244 4003 4481 4074 3795 4181 M13645 GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus. 29/34 Gene Ontology BP GO:1900078 3.41063298827185e-06 4.16199194713583e-06 2995 3457.72727272727 3796 3.10058025067797e-07 1476 1.71466936908637 1.78978768768175 1 9.84402076582 2995 4467 3266 3796 3786 2203 1476 4158 4053 3870 3965 4182 M14119 GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY.html The process in which a virus effects a change in the structure or processes of its host organism. 41/58 Gene Ontology BP GO:0019048 1.81531481978753e-06 2.35152000458558e-06 3805 3570 3797 1.65028756153069e-07 1856 1.2981247381457 -1.04142253780845 -1 7.77251382612452 3801 3401 3746 2665 3561 3847 3987 4646 1856 3963 3797 4183 M16525 GO_REGULATION_OF_GTPASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GTPASE_ACTIVITY.html Any process that modulates the rate of GTP hydrolysis by a GTPase. 620/772 Gene Ontology BP GO:0043087 3.14473776503998e-08 1.97691467186943e-07 3890 2927.27272727273 3797 3.14473780954218e-09 570 1.9094615060504 2.11111336804436 1 13.7022016875599 3890 1232 4630 2225 570 3797 3832 4505 2026 840 4653 4184 M13105 GO_MATURATION_OF_LSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_LSU_RRNA.html Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. 14/17 Gene Ontology BP GO:0000470 0.000523502566448947 0.000539383844483382 1360 3222.72727272727 3799 4.76024707627128e-05 1209 0.643981525475185 0.643981525475185 1 2.15825003534494 1360 4062 3882 3799 4504 1914 1209 2487 4582 4626 3025 4185 M14711 GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MICROTUBULE_POLYMERIZATION.html Any process that activates or increases the frequency, rate or extent of microtubule polymerization. 21/22 Gene Ontology BP GO:0031116 1.21112250090165e-05 1.38087551989595e-05 1695 2920.45454545455 3799 1.10102651664206e-06 579 1.10246748292366 1.187635102636 1 5.6692320560185 1695 4508 3799 4449 4060 1317 642 2829 3874 4373 579 4186 M13041 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. 20/21 Gene Ontology BP GO:1904357 2.94168897665787e-05 3.21846938311202e-05 1260 3053 3801 2.67429846512712e-06 801 1.0766495140431 1.18497191940418 1 5.10680730642447 1260 4240 3851 3801 4231 1653 801 2756 3928 4451 2611 4187 M13683 GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. 17/18 Gene Ontology BP GO:1902165 2.82779253631593e-05 3.09739140100707e-05 2095 3317 3801 2.57075353117368e-06 1577 1.33741689810275 1.24577415678649 1 6.39511928904333 2094 4022 3456 4419 4227 1983 1577 3801 4091 3946 2871 4188 M14333 GO_HISTONE_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_UBIQUITINATION.html The modification of histones by addition of ubiquitin groups. 37/40 Gene Ontology BP GO:0016574 3.2504710515634e-06 3.97802256783917e-06 2925 3732.27272727273 3801 2.95497804918322e-07 2731 0.852221411946395 0.838945160538952 1 4.85382691920927 2922 3947 4050 4257 3773 3482 3406 2731 4348 4338 3801 4189 M11883 GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_ACETYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. 16/22 Gene Ontology BP GO:0035067 0.000126024921865133 0.000132518409364625 1200 2820.45454545455 3802 1.14574674238869e-05 278 0.653911508379956 0.675736217068343 1 2.6234968580636 1197 3802 3922 3807 4412 597 278 2062 4609 4618 1721 4190 M12266 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation. 8/13 Gene Ontology BP GO:0043371 5.65551272917672e-07 8.73965484186626e-07 3455 3825.63636363636 3802 5.65551416849433e-08 3033 1.92064596999238 -2.99184432350259 -1 12.4451037927694 3455 4308 4358 4150 3033 4109 4448 3245 3374 3802 3800 4191 M13560 GO_BICARBONATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_BICARBONATE_TRANSPORT.html The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 24/52 Gene Ontology BP GO:0015701 1.20059098869811e-06 1.64304407953303e-06 4495 3400.63636363636 3802 1.09144694898995e-07 1132 1.97999950209124 -1.99482022112747 -1 12.2473530590894 4495 2800 1807 4365 3364 4306 3802 2802 4099 1132 4435 4192 M15457 GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_TYROSINE_KINASE_SIGNALING_PATHWAY.html A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. 508/655 Gene Ontology BP GO:0007169 2.26094018894766e-08 1.97691467186943e-07 4050 2728.81818181818 3802 2.26094021195098e-09 256 1.93983608173066 -1.68559420205078 -1 13.9219672365911 4048 1268 4558 740 256 4145 3938 4241 1930 1091 3802 4193 M11434 GO_RETINOL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETINOL_METABOLIC_PROCESS.html The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. 27/44 Gene Ontology BP GO:0042572 4.49045113429641e-08 1.97691467186943e-07 4585 3149.81818181818 3803 4.08222838722878e-09 893 2.54973268583738 1.98193229052865 1 18.3346794820123 4584 1886 1309 3862 893 4618 4429 3803 4015 1538 3711 4194 M13203 GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MAINTENANCE_OF_PROTEIN_LOCALIZATION_IN_ORGANELLE.html Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. 35/43 Gene Ontology BP GO:0072595 2.2460190241115e-06 2.85071645367999e-06 3695 3763.45454545455 3803 2.04183756101404e-07 2812 0.907470659903514 -0.766131135682975 -1 5.3175590069423 3692 3948 3896 3803 3635 3165 2812 4372 4405 4099 3571 4195 M14500 GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_PHOSPHATE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate. 67/83 Gene Ontology BP GO:1901292 1.03550189879418e-07 2.63001655845486e-07 3960 3595.27272727273 3803 9.41365406848602e-09 1765 1.66641097838714 -1.54647729508214 -1 11.720733152531 3957 4400 3302 4506 1765 3803 3277 3933 3632 2705 4268 4196 M11750 GO_RNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_METHYLATION.html Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. 54/57 Gene Ontology BP GO:0001510 3.58947391854882e-06 4.36306743547745e-06 3095 3595.54545454545 3804 3.26316343188424e-07 2039 0.876671413934599 0.789461233728761 1 4.95836342175749 3091 4160 4098 4051 3804 2764 2039 3037 4334 4448 3725 4197 M10847 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. 14/15 Gene Ontology BP GO:0043923 1.39752455798593e-06 1.87397169115519e-06 4090 3846.45454545455 3806 1.27047767795275e-07 3355 1.04429563015255 -0.971126807819773 -1 6.34170868398229 4089 3806 3629 3710 3438 4206 3971 3491 4242 3355 4374 4198 M15353 GO_SPERMATID_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERMATID_DIFFERENTIATION.html The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. 113/283 Gene Ontology BP GO:0048515 2.85191209825625e-07 5.1001445150183e-07 2550 3449 3806 2.59264769814222e-08 2084 1.41862896037015 1.47827633690381 1 9.52077622312793 2547 4356 3908 4565 2559 2808 2084 4129 3806 4100 3077 4199 M12463 GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_FOOD.html Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. 8/12 Gene Ontology BP GO:0032096 0.000221175935810956 0.000230024950676884 4480 3637.27272727273 3808 2.21197952352615e-05 1959 3.44543537353819 -2.23908684953867 -1 13.4153595548426 4478 3572 4370 3497 4466 3874 3808 2845 1959 2809 4332 4200 M14104 GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. 14/18 Gene Ontology BP GO:0042754 6.93050642045372e-06 8.1003884386765e-06 3070 3436.45454545455 3808 6.3004802302187e-07 1953 1.34934516008358 1.15267490374974 1 7.30142008091047 3070 3808 3322 3948 3954 2638 1953 3836 3881 2957 4434 4201 M15180 GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TELOMERE_MAINTENANCE.html Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. 30/31 Gene Ontology BP GO:0032205 0.00011044424046414 0.000116371614782528 995 2912.45454545455 3808 1.00408895788733e-05 465 0.946681243655777 1.05140978651899 1 3.90637995253901 995 4196 3978 3808 4400 1559 465 1840 4010 4477 2309 4202 M15206 GO_STEROL_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_STEROL_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 43/70 Gene Ontology BP GO:0016126 8.22855889489167e-07 1.19201383991068e-06 2655 3590.81818181818 3808 7.48051088416668e-08 2653 1.3644091482785 -1.43098463680632 -1 8.60965691953291 2653 4167 3808 4004 3177 3427 3965 2705 3966 4139 3488 4203 M10881 GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. 14/20 Gene Ontology BP GO:0000380 0.000108102469421448 0.000114059136103855 2580 3592.54545454545 3809 9.82798015186213e-06 1774 0.939662250836305 0.726697141151683 1 3.88541828604918 2580 3809 3787 3192 4395 2952 1774 4385 3901 4342 4401 4204 M15702 GO_NEGATIVE_REGULATION_OF_APPETITE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_APPETITE.html Any process that reduces appetite. 8/12 Gene Ontology BP GO:0032099 0.000221175935810956 0.000230024950676884 4480 3659 3809 2.21197952352615e-05 1960 3.44543537353819 -2.23908684953867 -1 13.4153595548426 4479 3573 4568 3498 4467 3875 3809 2872 1960 2815 4333 4205 M12754 GO_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. 39/50 Gene Ontology BP GO:0009112 1.46465353350479e-06 1.95329116979013e-06 3635 3813.63636363636 3810 1.33150409872831e-07 2660 1.23929908531212 1.50150362915093 1 7.52294772737605 3635 4174 3810 4208 3460 4373 4402 2660 3546 4113 3569 4206 M13272 GO_PROTEIN_AUTOUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_AUTOUBIQUITINATION.html The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. 47/55 Gene Ontology BP GO:0051865 1.14035523891189e-05 1.30146502983984e-05 3650 3555.18181818182 3810 1.03669195446332e-06 2300 1.07488648957585 -1.27415509330647 -1 5.55441142535261 3650 3070 3982 2973 4054 4131 3861 3810 2300 4310 2966 4207 M13293 GO_ELECTRON_TRANSPORT_CHAIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_ELECTRON_TRANSPORT_CHAIN.html A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. 92/110 Gene Ontology BP GO:0022900 0.226553056386824 0.227481953251595 870 3435.72727272727 3811 0.0230837792738479 869 0.994740623012781 -0.8946873341351 -1 0.577255390972515 869 4139 4161 3842 4621 2731 2188 3326 3811 4569 3536 4208 M13747 GO_MRNA_CLEAVAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CLEAVAGE.html Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. 21/22 Gene Ontology BP GO:0006379 1.76463415364951e-07 3.65481746361674e-07 3965 3663.90909090909 3812 1.60421299562906e-08 2203 1.15327339100385 -0.911691243764668 -1 7.89887476818366 3963 4510 3812 4430 2203 3612 2791 2831 3413 4270 4468 4209 M13799 GO_PROTEIN_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_UBIQUITINATION.html The process in which one or more ubiquitin groups are added to a protein. 590/718 Gene Ontology BP GO:0016567 1.06574414404892e-07 2.66364548829741e-07 3815 3669.36363636364 3812 1.0657441951604e-08 1873 1.36715930542913 -1.31170604543621 -1 9.58748931172162 3812 4321 4449 4473 1873 3113 3261 4232 3001 4533 3295 4210 M15874 GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 45/58 Gene Ontology BP GO:0072523 1.22228072992121e-05 1.39257400497634e-05 3530 3819.36363636364 3812 1.1111704734069e-06 3236 1.64443856419331 -1.45080496032112 -1 8.50531304214791 3528 4443 3475 4524 4063 3559 3812 3236 3929 3563 3881 4211 M16359 GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOSYL_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycosyl compound. 112/135 Gene Ontology BP GO:1901659 9.36390716758662e-07 1.33160941475491e-06 3745 3733.72727272727 3812 8.51264650288081e-08 2788 1.28109354264731 -0.980081325997186 -1 8.01051819443682 3743 4122 4044 3812 3241 3146 2788 4479 3026 4204 4466 4212 M10673 GO_ENERGY_RESERVE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_RESERVE_METABOLIC_PROCESS.html The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. 67/89 Gene Ontology BP GO:0006112 3.53409138670279e-07 6.02932485764035e-07 2375 3322.90909090909 3813 3.21281086765562e-08 1594 1.23091467292817 1.52082849359052 1 8.14945378311391 2371 4407 3916 4291 2687 2459 1594 3813 4059 4385 2570 4213 M12503 GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY.html Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity. 9/107 Gene Ontology BP GO:0048387 2.15930020870106e-05 2.39333584351739e-05 3860 3583.72727272727 3813 2.15932119058625e-06 1979 1.41015834997611 -1.48780886586652 -1 6.91953790663711 3856 3273 4372 3670 4194 3813 4531 1979 2695 3900 3138 4214 M12141 GO_REGULATION_OF_BONE_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of bone development. 13/31 Gene Ontology BP GO:1903010 5.91298941817442e-05 6.33797276267348e-05 4445 3705.90909090909 3815 5.37558940809049e-06 2194 2.58018237722471 -3.40066866549827 -1 11.5768502872841 4442 3547 2194 3474 4325 4486 4583 3815 3969 2791 3139 4215 M14180 GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. 82/97 Gene Ontology BP GO:0009124 6.85397040295188e-07 1.02380495296742e-06 3820 3553.54545454545 3817 6.23088412569721e-08 2638 1.23369068258399 -0.994130929536349 -1 7.86192564479071 2638 4136 4037 4258 3079 3110 2724 3817 3226 4244 3820 4216 M10392 GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 15/18 Gene Ontology BP GO:0009151 3.23982069224293e-05 3.52876537476741e-05 3715 3918.54545454545 3818 2.94533491300815e-06 3380 1.36817230721474 -0.804137607703794 -1 6.46116953341126 3714 4267 3380 3963 4251 3818 3757 3885 3683 3811 4575 4217 M10356 GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal. 167/205 Gene Ontology BP GO:1903321 6.04130202223838e-07 9.20136769540922e-07 3860 3791.63636363636 3821 5.49209425564416e-08 3013 1.32628412397234 -1.35196075949643 -1 8.52684830989713 3860 4338 4114 4067 3013 3486 3363 3710 3510 4426 3821 4218 M12690 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_MAPK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. 70/84 Gene Ontology BP GO:0032873 2.41301938542422e-06 3.03946377920382e-06 4470 3804.90909090909 3822 2.19365639281189e-07 2942 1.6405500307132 -1.1980979595894 -1 9.65529365837604 4469 4142 3368 3240 3663 3822 4462 2942 3865 3642 4239 4219 M13168 GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. 229/292 Gene Ontology BP GO:0009141 7.28204651023014e-07 1.07771508944341e-06 1785 3514.27272727273 3822 6.6200444732764e-08 1783 1.42037717770591 -1.13574680878842 -1 9.03457106268172 1783 4333 4104 4063 3111 2986 2678 3902 3387 4488 3822 4220 M14421 GO_KETONE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_KETONE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. 24/38 Gene Ontology BP GO:0042181 1.31482275256413e-07 3.00567137332123e-07 3610 3662.54545454545 3822 1.19529348285826e-08 1976 2.09484824808862 -1.93698303005097 -1 14.6321429031799 3608 4212 2697 3954 1976 3751 3822 4565 3984 4095 3624 4221 M14425 GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. 64/76 Gene Ontology BP GO:0009168 7.70919263529176e-06 8.95875957342971e-06 2785 3643.36363636364 3822 7.00838149982831e-07 2782 1.26998860058319 -0.986936300476343 -1 6.80541031490785 2782 4414 4017 3822 3976 3198 2816 3606 3107 4394 3945 4222 M14839 GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. 70/84 Gene Ontology BP GO:0070303 2.41301938542422e-06 3.03946377920382e-06 4470 3782.18181818182 3823 2.19365639281189e-07 2682 1.6405500307132 -1.1980979595894 -1 9.65529365837604 4470 4143 3369 3241 3664 3823 4463 2682 3866 3643 4240 4223 M15156 GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar. 64/76 Gene Ontology BP GO:0009127 7.70919263529176e-06 8.95875957342971e-06 2785 3646.54545454545 3823 7.00838149982831e-07 2783 1.26998860058319 -0.986936300476343 -1 6.80541031490785 2783 4415 4018 3823 3977 3199 2817 3631 3108 4395 3946 4224 M16380 GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SOMATIC_RECOMBINATION_OF_IMMUNOGLOBULIN_GENE_SEGMENTS.html The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. 20/23 Gene Ontology BP GO:0016447 1.28049231155028e-05 1.45639959072194e-05 1390 3130.54545454545 3823 1.16409069510324e-06 1389 1.03136860863088 0.967277492242405 1 5.27058446261042 1389 4241 3823 4019 4070 1766 1398 2490 4145 3922 3173 4225 M12719 GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interferon-beta production. 48/71 Gene Ontology BP GO:0032728 5.1210391339925e-06 6.07862119654773e-06 4450 3739.81818181818 3825 4.65550095864082e-07 2976 1.56240844989282 -1.41210696191749 -1 8.68245219444331 4449 3924 3235 4440 3893 4081 2976 3095 3825 3568 3652 4226 M12741 GO_REGULATION_OF_FIBRINOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FIBRINOLYSIS.html Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. 9/20 Gene Ontology BP GO:0051917 6.91888179901656e-05 7.3906237398586e-05 3165 3774.72727272727 3826 6.91909722762067e-06 3165 3.3345563629912 3.09498386737664 1 14.7545201086022 3165 3841 4386 3468 4354 3826 3456 3452 4094 3533 3947 4227 M13659 GO_TRNA_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_TRANSPORT.html The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 35/40 Gene Ontology BP GO:0051031 1.34283504244698e-05 1.52209779598192e-05 540 2907.90909090909 3826 1.22076658082519e-06 434 0.778502960672904 0.620174067234969 1 3.93454134882017 539 3966 4021 3826 4083 1140 434 2300 4432 4508 2738 4228 M13727 GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). 86/103 Gene Ontology BP GO:0042451 3.79987021068847e-06 4.59599586439653e-06 3275 3777.81818181818 3827 3.45443343081123e-07 2881 1.2270439983348 -0.988303404369239 -1 6.95532354556702 3275 4140 4060 3827 3818 3058 2881 4389 3396 4392 4320 4229 M16116 GO_PEPTIDYL_METHIONINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_METHIONINE_MODIFICATION.html The modification of peptidyl-methionine. 10/12 Gene Ontology BP GO:0018206 0.651622094859606 0.652603875889313 4635 3842.27272727273 3827 0.0914094057678734 2487 0.871499380076495 0.871499380076495 1 0.0612335108586294 2487 4594 3827 4246 4631 3379 2783 3782 4634 4219 3683 4230 M12540 GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_METHYLATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones. 21/22 Gene Ontology BP GO:0031061 1.50166341809984e-05 1.69510914226554e-05 3305 3554.63636363636 3828 1.36515788015097e-06 1208 0.945021750563268 1.18796949818009 1 4.75263036806623 3305 3999 3828 3542 4097 4401 3169 3198 4229 4125 1208 4231 M14438 GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION.html Any process that stops, prevents or reduces the rate or extent of B cell proliferation. 20/36 Gene Ontology BP GO:0030889 0.0118206047456016 0.0119750215286924 2820 3666.09090909091 3828 0.0010804180706391 2667 2.26697003837767 -2.32482352213379 -1 4.58856351592636 2817 4234 2667 3953 4579 3828 4595 3167 4296 3056 3135 4232 M16242 GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_RIBONUCLEOSIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. 86/103 Gene Ontology BP GO:0046129 3.79987021068847e-06 4.59599586439653e-06 3280 3777.72727272727 3828 3.45443343081123e-07 2882 1.2270439983348 -0.988303404369239 -1 6.95532354556702 3276 4141 4061 3828 3819 3059 2882 4378 3397 4393 4321 4233 M12433 GO_RNA_SURVEILLANCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SURVEILLANCE.html The set of processes involved in identifying and degrading defective or aberrant RNAs. 14/14 Gene Ontology BP GO:0071025 2.77408897418914e-05 3.04286562868979e-05 4560 3560.36363636364 3829 2.52193086788059e-06 1992 1.11100497252883 1.29629113746321 1 5.30258873287813 2525 4558 3829 4556 4224 2767 1992 2890 4386 3987 3450 4234 M13347 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. 37/78 Gene Ontology BP GO:0032732 0.0002826316450037 0.000293087819077829 2780 3648.27272727273 3830 2.5697087356401e-05 2483 1.79882087676112 -1.92268048782752 -1 6.74567541513472 2780 4183 2483 4255 4475 3398 4029 3727 4433 2538 3830 4235 M15475 GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_C_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the C-terminal amino acid residue in a protein. 11/16 Gene Ontology BP GO:0018410 0.00393558830159873 0.00400882057078347 2475 3375.63636363636 3830 0.000358422397581413 1888 0.715400106166712 -0.812022993067437 -1 1.73757079785756 2473 4580 3830 4435 4603 2382 1888 1899 4626 4257 2159 4236 M15480 GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation. 10/17 Gene Ontology BP GO:0046639 2.60877183529781e-06 3.25519317501762e-06 4330 3872.27272727273 3831 2.37161357163511e-07 2989 1.7986364689386 1.00316456589594 1 10.5387870317379 4326 3831 2989 3506 3700 4474 4246 3897 3603 3653 4370 4237 M14955 GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING_IN_ENDOPLASMIC_RETICULUM.html A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). 18/21 Gene Ontology BP GO:0034975 0.0156535684193346 0.0158408120607142 2135 3622.63636363636 3832 0.00143327907989874 2132 0.774868710356364 0.845608225373516 1 1.39236130515843 2132 4274 3883 3832 4585 2823 2769 3337 4633 4419 3162 4238 M14934 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. 42/45 Gene Ontology BP GO:0006383 4.27235873936996e-07 6.95809772988745e-07 3555 3880.27272727273 3833 3.88396324459476e-08 2819 0.769832748669841 -0.678031379533462 -1 5.00273198011973 3552 4459 4107 4606 2819 3252 3782 3156 4577 4540 3833 4239 M14936 GO_POSITIVE_REGULATION_OF_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEOLYSIS.html Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. 431/537 Gene Ontology BP GO:0045862 6.73442115126412e-08 2.1912770361421e-07 3990 3417.18181818182 3833 6.1222012340105e-09 1334 1.88877668949589 -1.59162435893355 -1 13.461406514203 3987 3591 2859 3216 1334 4278 4189 4025 2128 3833 4149 4240 M12072 GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_HISTONE_MODIFICATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone. 43/57 Gene Ontology BP GO:0031057 4.9746177525842e-06 5.9093429672643e-06 1795 3357.90909090909 3835 4.52239000106833e-07 1795 0.824435692000678 1.00068498517533 1 4.53896166725003 1795 4449 4082 3835 3890 2478 2232 3173 4400 4460 2143 4241 M13222 GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ACYL_COA_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. 12/14 Gene Ontology BP GO:0050812 0.053090637162368 0.0535509938687402 4110 3626.45454545455 3835 0.00494698680577141 2020 1.35665584783055 -0.812774534658181 -1 1.74817186336934 4107 4300 3687 2978 4597 4176 2020 3116 3835 3846 3229 4242 M11152 GO_RESPONSE_TO_MORPHINE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MORPHINE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. 28/40 Gene Ontology BP GO:0043278 2.35020794240565e-05 2.59442883891186e-05 3355 3855.18181818182 3836 2.13657549954225e-06 3068 1.85024515806145 -1.61596939784905 -1 9.04434009831647 3354 4478 3068 4420 4192 3203 4109 4639 3795 3313 3836 4243 M16195 GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_ISOQUINOLINE_ALKALOID.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. 28/40 Gene Ontology BP GO:0014072 2.35020794240565e-05 2.59442883891186e-05 3355 3856.63636363636 3837 2.13657549954225e-06 3069 1.85024515806145 -1.61596939784905 -1 9.04434009831647 3355 4479 3069 4421 4193 3204 4110 4640 3796 3319 3837 4244 M11544 GO_PROTEIN_LOCALIZATION_TO_CENTROSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CENTROSOME.html A process in which a protein is transported to, or maintained at, the centrosome. 22/22 Gene Ontology BP GO:0071539 9.63648495901088e-08 2.53938011162528e-07 4345 3593.54545454545 3838 8.76044125555473e-09 1701 1.13475164293424 -1.05515035300223 -1 7.96386646549015 4343 3748 3703 3973 1701 4509 4328 2616 4122 3838 2648 4245 M11671 GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. 22/28 Gene Ontology BP GO:0044788 1.77488020010988e-05 1.98522056997867e-05 3550 3759.72727272727 3839 1.61354047214661e-06 2242 2.24389160371708 -2.33549917574127 -1 11.2740975272358 3546 4498 2907 4544 4139 4641 4365 2242 3590 3839 3046 4246 M16156 GO_CELLULAR_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state at the level of the cell. 599/901 Gene Ontology BP GO:0019725 3.81784201367796e-08 1.97691467186943e-07 3840 2930.27272727273 3839 3.81784207926958e-09 345 2.1589900878677 2.32719398401255 1 15.5075861103516 3839 2115 4599 1457 787 4039 4221 3977 2429 345 4425 4247 M10434 GO_MRNA_SPLICE_SITE_SELECTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_SPLICE_SITE_SELECTION.html Selection of a splice site by components of the assembling spliceosome. 30/42 Gene Ontology BP GO:0006376 8.464397332742e-06 9.79966180374434e-06 2060 3594.63636363636 3840 7.69493627208285e-07 2060 1.19099395630902 0.963520725698654 1 6.32499006933727 2060 4194 3840 3705 3992 3119 2751 3706 3960 4174 4040 4248 M12786 GO_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_FISSION.html The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 14/15 Gene Ontology BP GO:0000266 0.000281437135236483 0.000291914175268693 2935 3740.36363636364 3841 2.55884677095007e-05 2351 1.01777294305638 -0.752809202107075 -1 3.76951056030191 2933 4556 3738 4536 4474 2966 2351 3841 4352 4181 3216 4249 M13842 GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INCLUSION_BODY_ASSEMBLY.html Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. 22/25 Gene Ontology BP GO:0090083 9.52870269773111e-05 0.000100788937605235 4385 3783.09090909091 3841 8.66283221149567e-06 2883 1.86572789650365 1.71428453043463 1 7.93423944799972 3460 4000 2883 3711 4384 3630 3032 4148 4141 3841 4384 4250 M14217 GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region. 15/16 Gene Ontology BP GO:1904814 0.000254100656804484 0.000263795260176542 1145 2910.45454545455 3841 2.31027282047982e-05 512 1.0828063112429 1.17695420726688 1 4.06900491332498 1144 4268 3841 4008 4470 1713 512 1651 4077 4040 2291 4251 M14706 GO_RRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an rRNA molecule. 13/14 Gene Ontology BP GO:0031125 0.00233011970898152 0.00237764188725681 2000 3606.90909090909 3842 0.000212053755458862 1999 0.821074000153902 0.887555880760961 1 2.21197480665639 1999 4579 3842 4561 4547 2721 2061 3176 4574 4133 3483 4252 M12759 GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_FEMALE_GONAD_DEVELOPMENT.html Any process that modulates the frequency, rate or extent of female gonad development. 6/17 Gene Ontology BP GO:2000194 3.79479062129775e-06 4.59343412094132e-06 4550 3632.09090909091 3845 3.79479710150946e-07 2242 2.50503729559824 -3.24813847198272 -1 14.317894253641 4548 3282 4387 2517 3845 4435 4031 3809 3931 2926 2242 4253 M16520 GO_ENDODERMAL_CELL_FATE_COMMITMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENDODERMAL_CELL_FATE_COMMITMENT.html The cell differentiation process that results in commitment of a cell to become part of the endoderm. 7/16 Gene Ontology BP GO:0001711 0.000172474413080325 0.000180099516172072 3845 4020.72727272727 3845 1.72487800883174e-05 3495 0.866134683658679 -0.891702999953178 -1 3.38709872404157 3495 3844 4629 3744 4451 3845 4355 3839 4152 4061 3813 4254 M11117 GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOLYTIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. 14/18 Gene Ontology BP GO:0045820 4.18655586023059e-06 5.02970421318176e-06 3975 3742.54545454545 3846 3.80596711562147e-07 2410 1.23585877625426 -1.0724159460669 -1 6.95386682869929 3974 3803 3361 4188 3846 3637 4111 3672 4181 3985 2410 4255 M11414 GO_DNA_INTEGRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_INTEGRATION.html The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. 7/7 Gene Ontology BP GO:0015074 0.00846311978650429 0.0085886360668712 3785 3751.63636363636 3846 0.000849552458924857 2193 0.936109983691305 1.09955740496025 1 1.9742160615968 3783 3846 4299 3987 4582 3702 2992 2193 4492 4060 3332 4256 M13702 GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. 34/36 Gene Ontology BP GO:0000959 9.66997615650841e-06 1.11210851545869e-05 3850 3571.81818181818 3846 8.7909260550962e-07 2356 0.874809755609287 -1.02261967000558 -1 4.56394488973975 3846 2356 3960 3997 4018 3698 3266 2494 4331 4284 3040 4257 M14564 GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COENZYME_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme. 14/18 Gene Ontology BP GO:0051198 4.18655586023059e-06 5.02970421318176e-06 3640 3740.72727272727 3847 3.80596711562147e-07 2411 1.23585877625426 -1.0724159460669 -1 6.95386682869929 3975 3804 3362 4189 3847 3638 4112 3639 4182 3989 2411 4258 M10151 GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION.html The acetylation of the N-terminal amino acid of proteins. 13/15 Gene Ontology BP GO:0006474 0.00618357492301073 0.00628487857509151 3070 3634 3848 0.000563729445061438 1665 0.733581545088355 0.712318435657559 1 1.63000012946414 3067 4294 3848 4226 4563 2939 1665 3100 4528 4314 3430 4259 M15248 GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor. 14/18 Gene Ontology BP GO:0051195 4.18655586023059e-06 5.02970421318176e-06 3980 3744.54545454545 3848 3.80596711562147e-07 2412 1.23585877625426 -1.0724159460669 -1 6.95386682869929 3976 3805 3363 4190 3848 3639 4113 3670 4183 3991 2412 4260 M15500 GO_POSITIVE_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSPORT.html Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 995/1446 Gene Ontology BP GO:0051050 4.11166714972766e-10 8.24637381365638e-09 3880 2737 3848 4.11166715048842e-11 109 2.20808113455568 2.3834547771464 1 19.1506954828176 3880 1175 4559 902 679 4101 3848 4239 2154 109 4461 4261 M15903 GO_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_STRESS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 1708/2159 Gene Ontology BP GO:0033554 1.17373883037785e-07 2.82243244328069e-07 3220 3631 3848 1.17373889237268e-08 1958 1.71235358616676 1.84118941493805 1 11.9903195849661 3218 3848 4580 4270 1958 3077 3552 4075 2878 4494 3991 4262 M10424 GO_RIBOSOME_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. 326/424 Gene Ontology BP GO:0042254 2.61115492177668e-05 2.87023478644623e-05 1605 3591.81818181818 3851 2.37380537617434e-06 1603 0.816438039317024 0.790741879370707 1 3.8890477061776 1603 4635 4188 3851 4210 2786 2187 3046 4568 4608 3828 4263 M11854 GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process. 122/129 Gene Ontology BP GO:1901800 2.1289275104306e-07 4.13733956906777e-07 3450 3472.36363636364 3853 1.93538883313248e-08 1884 1.47633001636477 1.56522490029197 1 10.0573921560166 3449 4117 3853 4229 2351 3037 2347 4049 1884 4301 4579 4264 M10088 GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR.html Any process that modulates the frequency, rate or extent of double-strand break repair. 43/48 Gene Ontology BP GO:2000779 2.5628346598974e-05 2.82111891944703e-05 2775 3784.27272727273 3855 2.32987683225638e-06 2773 1.19260939490671 1.49885116401919 1 5.74267223314305 2773 4450 3855 4574 4204 3491 3180 3528 4336 3931 3305 4265 M15630 GO_REGULATION_OF_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSPORT.html Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 1700/2497 Gene Ontology BP GO:0051049 3.13981251571384e-13 1.12609438028021e-11 4610 2807.45454545455 3855 3.13981251571428e-14 62 2.16702067698068 -1.97737158948685 -1 25.4921697388824 4607 1137 4566 874 808 4419 4475 4265 1814 62 3855 4266 M12247 GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_POLYMERASE_II_TRANSCRIPTIONAL_PREINITIATION_COMPLEX_ASSEMBLY.html Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. 13/14 Gene Ontology BP GO:0045898 0.0514866850903371 0.0519443941295183 2490 3678.90909090909 3856 0.00479387722819495 2489 0.915201749702678 0.957605766610624 1 1.15558343385208 2489 4583 3856 4250 4607 3079 3257 2789 4410 4130 3018 4267 M15562 GO_PROTEIN_REFOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_REFOLDING.html The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. 26/28 Gene Ontology BP GO:0042026 7.04435346123987e-07 1.04787009767101e-06 2970 3747.45454545455 3859 6.40395974257088e-08 2824 0.852954934996816 0.976322418546976 1 5.39142348732267 2967 4497 3859 4596 3093 3100 2824 3914 4635 4378 3359 4268 M13379 GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 13/15 Gene Ontology BP GO:0009113 8.43957208412798e-06 9.77335214222187e-06 1965 3634.81818181818 3860 7.6723676908434e-07 1962 0.662366618901989 0.696984122971015 1 3.46825419036029 1962 4287 3860 4215 3991 2777 3589 2989 4536 4317 3460 4269 M11638 GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_T_HELPER_2_CELL_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. 8/15 Gene Ontology BP GO:0045628 7.10077205885319e-06 8.29106458967225e-06 2840 3582.54545454545 3862 7.10079474838895e-07 2603 1.78708935601162 -2.11096475810884 -1 9.68729271303964 2840 3565 4318 2603 3980 3862 4575 3877 4237 2805 2746 4270 M13825 GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEOXYRIBONUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 35/39 Gene Ontology BP GO:0009262 2.43422905913714e-08 1.97691467186943e-07 4445 3515 3862 2.2129355327919e-09 241 1.46019842590413 -1.23752793880842 -1 10.4517020424919 4445 3946 3352 4375 241 4136 3458 3862 3007 3196 4647 4271 M11210 GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar. 17/21 Gene Ontology BP GO:0009148 5.63769740185614e-06 6.66468648649305e-06 3865 3839 3864 5.1251925900122e-07 3191 0.895127152701522 -0.813751164418585 -1 4.8873868193817 3864 3191 3745 3968 3909 3566 3376 4580 4086 3695 4249 4272 M14997 GO_REGULATION_OF_BONE_RESORPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_BONE_RESORPTION.html Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). 33/43 Gene Ontology BP GO:0045124 1.89082033893958e-07 3.82687561421743e-07 4210 3144.72727272727 3865 1.71892772858979e-08 819 2.69234472905904 -2.89562745966792 -1 18.5329952645868 4208 2353 841 3618 2259 4007 3865 4630 4036 819 3956 4273 M13816 GO_NEGATIVE_REGULATION_OF_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_BEHAVIOR.html Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. 7/21 Gene Ontology BP GO:0048521 6.56137790164304e-05 7.01841181065404e-05 4215 3418.18181818182 3867 6.56157164225392e-06 786 2.61234866576822 3.33351586983164 1 11.5977212508124 4214 3843 4451 3867 4344 3749 1685 4043 786 2513 4105 4274 M11286 GO_PROTEIN_NEDDYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_NEDDYLATION.html Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. 14/16 Gene Ontology BP GO:0045116 0.102294418199448 0.103002797637315 2650 3783.09090909091 3868 0.00976232016976101 2649 1.10253921526324 1.10253921526324 1 1.06150836180564 2649 4571 3868 4557 4606 3154 3179 3032 4515 4179 3304 4275 M15254 GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_SEQUESTERING_OF_PROTEIN.html The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. 49/58 Gene Ontology BP GO:0051220 3.79905727420147e-06 4.59599586439653e-06 4125 3783.36363636364 3868 3.45369439508856e-07 2217 1.22119261665049 1.40605504891056 1 6.92161649792963 4122 3067 3748 2217 3817 4392 4512 4059 3798 4017 3868 4276 M12813 GO_CELL_REDOX_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_REDOX_HOMEOSTASIS.html Any process that maintains the redox environment of a cell or compartment within a cell. 59/76 Gene Ontology BP GO:0045454 2.43515944602726e-05 2.6850229626457e-05 2140 3473.54545454545 3869 2.21380581908852e-06 1977 1.50342954257464 -1.81340740395242 -1 7.30365583377949 2140 4420 3872 4259 4198 3411 2854 1977 3869 4109 3100 4277 M14906 GO_URATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_URATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. 9/18 Gene Ontology BP GO:0046415 1.56075392103059e-05 1.75797337074687e-05 2765 3502.36363636364 3869 1.56076488292655e-06 1841 1.26066631468369 1.34435469166544 1 6.35630451824399 2763 4069 4524 4145 4132 2588 1841 3869 4174 3011 3410 4278 M14888 GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_POLYSACCHARIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. 45/59 Gene Ontology BP GO:0032881 4.28233096027552e-07 6.96945993639803e-07 3875 3645.45454545455 3873 3.89302890348863e-08 2251 1.59931825899847 2.21705940801322 1 10.5137537247248 4035 3932 3174 4225 2821 4133 4472 2251 3871 3873 3313 4279 M11044 GO_MALE_SEX_DETERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MALE_SEX_DETERMINATION.html The specification of male sex of an individual organism. 8/17 Gene Ontology BP GO:0030238 0.0622875881367477 0.0628004653521749 3985 3996 3875 0.00641056152614352 3334 1.36082837971069 -1.19212444029054 -1 1.65227275061084 3982 3842 4275 3757 4600 3672 4321 3875 4523 3334 3775 4280 M10577 GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPIRATORY_CHAIN_COMPLEX_IV_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. 17/18 Gene Ontology BP GO:0008535 0.000845547136352533 0.0008686974664271 2235 3510.18181818182 3877 7.68974807797154e-05 1754 0.709404079917391 -0.750250553285938 -1 2.23053888384635 2232 4539 3877 4035 4521 2551 3177 1754 4576 4405 2945 4281 M15886 GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. 21/26 Gene Ontology BP GO:0042762 0.00719830448360588 0.00730984521218205 3880 3835.09090909091 3877 0.000656542316308967 2997 1.32950298153261 -0.938482267790435 -1 2.95185544552507 3877 4233 3759 3993 4566 4615 3001 3622 2997 3969 3554 4282 M13310 GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ANTIGEN_PROCESSING_AND_PRESENTATION.html Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation. 10/35 Gene Ontology BP GO:0002579 2.02879963248645e-07 4.00679316212201e-07 4100 3549.09090909091 3879 1.84436347234423e-08 2309 2.37341572077868 2.91534635414453 1 16.2731138469464 4374 4072 2309 3433 2315 4303 4099 4099 3879 2684 3473 4283 M16031 GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. 53/70 Gene Ontology BP GO:0042273 6.74606296049476e-05 7.21098804391963e-05 1810 3489.27272727273 3883 6.13297257284341e-06 1580 0.832687932011109 0.737860175173716 1 3.60916928087868 1808 4178 4136 3844 4341 2402 1580 3054 4618 4538 3883 4284 M10177 GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY.html Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity. 31/37 Gene Ontology BP GO:1904030 2.15838325253421e-07 4.17934135415801e-07 4385 3714.36363636364 3884 1.96216678571783e-08 2360 1.9099460070416 -1.35104211778838 -1 13.0355459493569 4383 3710 3001 2956 2360 4640 4000 4424 3884 3588 3912 4285 M13137 GO_AMIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. 505/656 Gene Ontology BP GO:0043604 3.05327215221903e-07 5.37528389113702e-07 3210 3876.90909090909 3885 3.0532725717303e-08 2662 1.22852306021002 -1.11263767635255 -1 8.19951707855037 3208 4614 4409 4644 2662 3681 3717 3183 3885 4627 4016 4286 M11864 GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_LOCALIZATION_BY_MOVEMENT_ALONG_MICROTUBULE.html The movement of organelles or other particles from one location in the cell to another along microtubules. 117/133 Gene Ontology BP GO:0010970 2.33342344148159e-07 4.40716642252427e-07 3945 3667.09090909091 3887 2.12129426270499e-08 2418 1.3439607017336 -1.14230512834553 -1 9.10569754009055 3944 3019 3887 3471 2418 4648 3962 4450 3098 3937 3504 4287 M14408 GO_CELLULAR_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 45/62 Gene Ontology BP GO:0071359 1.98818242336074e-08 1.97691467186943e-07 3795 3574.63636363636 3888 1.80743858302575e-09 122 1.08815778886309 -0.95564743855388 -1 7.75992074085665 3793 3935 3888 3576 122 4139 4220 3473 4228 4093 3854 4288 M13235 GO_GLYOXYLATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYOXYLATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. 26/32 Gene Ontology BP GO:0046487 7.24909235225952e-07 1.07386267797082e-06 3830 3648 3889 6.59008612806088e-08 2101 1.67516240637569 -2.42569215772556 -1 10.6782784658617 3830 4206 3402 4178 3108 4423 3926 3889 2101 4171 2894 4289 M16564 GO_RNA_INTERFERENCE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_INTERFERENCE.html The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. 12/12 Gene Ontology BP GO:0016246 0.150520101018847 0.151365902321308 3430 3933.81818181818 3890 0.0147206667316279 2414 0.607759766639098 0.686917068211111 1 0.424732964824487 3427 4584 3890 4576 4609 3184 2414 3757 4648 4652 3531 4290 M16742 GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_GLUCOSE_IMPORT_IN_RESPONSE_TO_INSULIN_STIMULUS.html Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus. 16/18 Gene Ontology BP GO:2001275 0.00129725758789258 0.0013307185971041 3245 3675.90909090909 3890 0.000118002105834158 1595 1.30314078282289 0.911698865588204 1 3.93156028903194 3244 4266 3524 4239 4529 2705 1595 4329 4450 3890 3664 4291 M13281 GO_4_HYDROXYPROLINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_4_HYDROXYPROLINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls. 15/15 Gene Ontology BP GO:0019471 0.00217249662573927 0.0022182635065975 4040 3654.90909090909 3891 0.000197694993949377 1692 1.28587330752418 -1.03500727781613 -1 3.56998573581251 4228 4039 3593 3695 4545 3891 1692 2826 4193 4039 3463 4292 M16607 GO_MICROTUBULE_POLYMERIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MICROTUBULE_POLYMERIZATION.html The addition of tubulin heterodimers to one or both ends of a microtubule. 28/34 Gene Ontology BP GO:0046785 2.23012312540687e-05 2.46772007194249e-05 4585 3794.36363636364 3891 2.02740521119524e-06 2882 1.1760761015012 -1.11052162867807 -1 5.73526923764477 4582 3433 3794 2957 4182 4645 3891 4231 2915 4226 2882 4293 M11327 GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_MITOCHONDRIAL_DEPOLARISATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. 138/198 Gene Ontology BP GO:0098780 1.2674150598554e-07 2.93105480790615e-07 4475 3549.36363636364 3896 1.15219557533718e-08 1751 2.16043886325534 -1.67192117534027 -1 15.119278358613 4472 3336 1751 4077 1947 3896 4607 3990 3167 3328 4472 4294 M14253 GO_REGULATION_OF_ISOTYPE_SWITCHING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ISOTYPE_SWITCHING.html Any process that modulates the frequency, rate or extent of isotype switching. 18/29 Gene Ontology BP GO:0045191 3.31476429616792e-05 3.60785924446067e-05 4380 3851.09090909091 3896 3.01346749194653e-06 2788 1.51528999893378 -1.27270755408359 -1 7.15234829173945 4377 3195 3396 3438 4252 4554 3896 4563 2788 3790 4113 4295 M13888 GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOPHAGY_IN_RESPONSE_TO_MITOCHONDRIAL_DEPOLARIZATION.html The macromitophagy process that is triggered by a detection of the loss of mitochondrial membrane potential. 138/198 Gene Ontology BP GO:0098779 1.2674150598554e-07 2.93105480790615e-07 4475 3562.45454545455 3897 1.15219557533718e-08 1752 2.16043886325534 -1.67192117534027 -1 15.119278358613 4473 3337 1752 4078 1948 3897 4608 4124 3168 3329 4473 4296 M15648 GO_MACROMITOPHAGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMITOPHAGY.html Degradation of a mitochondrion by macroautophagy. 138/198 Gene Ontology BP GO:0000423 1.2674150598554e-07 2.93105480790615e-07 4475 3558.72727272727 3898 1.15219557533718e-08 1753 2.16043886325534 -1.67192117534027 -1 15.119278358613 4474 3338 1753 4079 1949 3898 4609 4073 3169 3330 4474 4297 M12745 GO_REGULATION_OF_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_3_END_PROCESSING.html Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule. 41/43 Gene Ontology BP GO:0031440 6.63142401611324e-06 7.76642737150136e-06 3630 3910.45454545455 3900 6.02858545926412e-07 3022 1.361056480522 1.55818899736608 1 7.39263072322749 3626 4175 3900 4446 3945 3697 3401 4604 3864 4335 3022 4298 M16965 GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. 28/42 Gene Ontology BP GO:0048025 0.00012376421974394 0.000130170640702657 1050 3192.45454545455 3902 1.12519257117878e-05 1049 1.01755685152515 0.885301582879333 1 4.15386400337069 1049 4207 3902 3998 4410 1856 1115 2910 4332 4108 3230 4299 M14166 GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION.html Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. 13/21 Gene Ontology BP GO:0032717 0.000219688282998036 0.000228631084945172 3905 3542.72727272727 3903 1.99736567060199e-05 1616 1.48881850537888 -1.8507188187476 -1 5.73697020622856 3903 4049 3209 3501 4460 4200 3857 1616 4231 3926 2018 4300 M12907 GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_CHROMOSOME_TELOMERIC_REGION.html Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. 16/16 Gene Ontology BP GO:0070198 2.57160393844735e-05 2.82876433229208e-05 2255 3587.09090909091 3904 2.33784908972503e-06 1832 0.832045830452078 0.745289410090474 1 3.97123221068147 2255 4554 3904 4568 4207 2423 1832 3603 4509 4250 3353 4301 M15192 GO_RESPONSE_TO_DSRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_DSRNA.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. 65/99 Gene Ontology BP GO:0043331 7.11378857089131e-08 2.23814099129341e-07 3905 3600.45454545455 3904 6.46708072810778e-09 1386 1.22460644305056 -1.22809660190661 -1 8.6759160095076 3258 3904 3901 4586 1386 3990 4003 2657 4315 4176 3429 4302 M16731 GO_REGULATION_OF_PROTEIN_TARGETING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING.html Any process that modulates the frequency, rate or extent of protein targeting. 362/501 Gene Ontology BP GO:1903533 8.39959940107676e-08 2.40809217579853e-07 4280 3538.45454545455 3906 7.63599974706679e-09 1547 1.67740363023083 1.81874213356264 1 11.8681045147479 4278 3308 3747 2679 1547 4394 4021 3906 2371 4221 4451 4303 M10043 GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DEPENDENT_DNA_REPLICATION_MAINTENANCE_OF_FIDELITY.html A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. 26/46 Gene Ontology BP GO:0045005 0.000261173570279153 0.000271077542384319 795 2707.18181818182 3909 2.37458709746682e-05 258 0.960957385519424 1.00058735979904 1 3.586124819934 794 3989 3909 4025 4471 799 258 1144 4462 4042 1886 4304 M16501 GO_RESPONSE_TO_UV_B http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_UV_B.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. 16/19 Gene Ontology BP GO:0010224 8.13481053231278e-05 8.65171963585175e-05 3720 3933.63636363636 3909 7.39555576726074e-06 3323 1.74956097134997 -1.65196220815659 -1 7.55838942470481 3718 4252 3323 3909 4361 4581 3661 3956 4441 3632 3436 4305 M15332 GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 308/352 Gene Ontology BP GO:0010498 1.10136358630014e-07 2.7085860290986e-07 3665 3679.18181818182 3910 1.00123967403326e-08 1823 1.3450703333508 -1.11093140600374 -1 9.42021055545972 3665 4629 4175 4072 1823 3231 3333 4346 2732 4555 3910 4306 M11284 GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_BY_HOST_OF_VIRAL_TRANSCRIPTION.html Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription. 11/16 Gene Ontology BP GO:0043922 0.00476573156274757 0.00484804306109848 4570 3936.90909090909 3911 0.000434189700626176 2850 1.2391332643078 -1.27278189863783 -1 2.98202118947794 2850 4593 3459 4569 4559 3295 3911 4530 4566 3737 3237 4307 M11834 GO_ERBB2_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERBB2_SIGNALING_PATHWAY.html A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. 53/61 Gene Ontology BP GO:0038128 2.45492545238801e-07 4.55090363743482e-07 4120 3446.36363636364 3911 2.23175066029736e-08 2273 1.7977059868712 -1.69342411160477 -1 12.191086426584 4116 3911 2794 2646 2466 4360 4084 4116 2273 4128 3016 4308 M12638 GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0034030 0.000130017332885057 0.000136531403726962 4080 3887.81818181818 3914 1.1820456126147e-05 2503 1.09304760203376 -1.25961509148427 -1 4.44598057298555 4078 4269 3689 4540 4416 3272 2503 3847 4354 3884 3914 4309 M11281 GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of mRNA metabolic process. 60/77 Gene Ontology BP GO:1903313 1.04194884094133e-05 1.19237283740777e-05 2305 3367.45454545455 3915 9.47230705254869e-07 1900 1.27373179145713 1.38874623910121 1 6.65511958269815 2304 4155 3915 4052 4041 2236 1900 3377 4273 4391 2398 4310 M13640 GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0034033 0.000130017332885057 0.000136531403726962 4080 3887.45454545455 3915 1.1820456126147e-05 2504 1.09304760203376 -1.25961509148427 -1 4.44598057298555 4079 4270 3690 4541 4417 3273 2504 3833 4355 3885 3915 4311 M14952 GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_BISPHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar. 16/17 Gene Ontology BP GO:0033866 0.000130017332885057 0.000136531403726962 4080 3889.90909090909 3916 1.1820456126147e-05 2505 1.09304760203376 -1.25961509148427 -1 4.44598057298555 4080 4271 3691 4542 4418 3274 2505 3848 4356 3888 3916 4312 M16672 GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. 25/37 Gene Ontology BP GO:0032897 2.94732208244448e-05 3.22300579309382e-05 3850 3767.09090909091 3916 2.67941960747179e-06 2968 1.38042095722849 1.23832767745803 1 6.57866689144419 3849 4216 3482 3977 4234 3916 2968 3352 4201 3307 3936 4313 M11110 GO_NCRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of a non-coding RNA molecule. 20/22 Gene Ontology BP GO:0043628 3.16226952513204e-05 3.44510421457256e-05 2070 3552.36363636364 3918 2.87483180032578e-06 2070 0.820740847585773 0.88308100351651 1 3.83991172302973 2070 4527 3918 4447 4250 2746 2440 2643 4550 4231 3254 4314 M10044 GO_TRNA_AMINOACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_AMINOACYLATION.html The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. 52/52 Gene Ontology BP GO:0043039 3.39845194737031e-05 3.69721695373253e-05 1835 3458.27272727273 3919 3.08954949647474e-06 1832 0.77234306958482 -0.887635569221855 -1 3.58124234464819 1832 3919 4122 4272 4254 2541 2487 3048 4212 4531 2823 4315 M11207 GO_PROTEASOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEASOME_ASSEMBLY.html The aggregation, arrangement and bonding together of a mature, active proteasome complex. 15/17 Gene Ontology BP GO:0043248 3.15848075875347e-05 3.44178242868381e-05 3320 4028.72727272727 3919 2.87138736829332e-06 3320 0.606983583953197 -0.592349181792877 -1 2.81064745761797 3320 4544 3919 4443 4249 3416 3834 3872 4567 4614 3538 4316 M10357 GO_AMINO_ACID_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_ACTIVATION.html The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. 52/52 Gene Ontology BP GO:0043038 3.39845194737031e-05 3.69721695373253e-05 1835 3455.27272727273 3920 3.08954949647474e-06 1833 0.77234306958482 -0.887635569221855 -1 3.58124234464819 1833 3920 4123 4273 4255 2542 2488 3005 4213 4532 2824 4317 M11283 GO_RESPONSE_TO_FUNGICIDE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_FUNGICIDE.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. 13/20 Gene Ontology BP GO:0060992 7.72793211392856e-05 8.23027423348812e-05 3845 3677 3924 7.02563962370309e-06 2275 1.78083764623006 -0.512350538318195 -1 7.73721480733837 3844 4293 3124 3988 4355 4517 4148 3118 2861 3924 2275 4318 M12255 GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PTERIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. 17/18 Gene Ontology BP GO:0042559 8.25418033710311e-07 1.19460967678198e-06 3925 3794.63636363636 3924 7.5038031218098e-08 2980 1.23865239516981 1.49889371358141 1 7.80442307704367 3924 3512 3599 4156 3180 4468 3945 2980 4209 3696 4072 4319 M15250 GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_CIS_SPLICING_VIA_SPLICEOSOME.html The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. 19/23 Gene Ontology BP GO:0045292 0.000362220347405397 0.000375035887066602 2415 3669.09090909091 3924 3.29345453769772e-05 2411 0.953265702323396 0.998972346975277 1 3.41147685381608 2411 4256 3924 4028 4481 2879 2495 3790 4382 4437 3277 4320 M15853 GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SIGNAL_TRANSDUCTION_BY_PROTEIN_PHOSPHORYLATION.html A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. 389/501 Gene Ontology BP GO:0023014 5.76489995093349e-08 2.07580109259326e-07 4525 3460.18181818182 3924 5.24081827454315e-09 1177 1.95218913832458 2.01391196869302 1 13.9666829297809 4521 4094 2773 2447 1177 4507 4408 3924 2924 3191 4096 4321 M12806 GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_BIOSYNTHETIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme. 26/43 Gene Ontology BP GO:0051769 4.50986262175914e-06 5.3916728620363e-06 4600 3680.45454545455 3925 4.09988351520221e-07 2450 1.98024063885976 -1.7665709367183 -1 11.1459363364504 4599 3450 2582 2450 3866 4575 3925 4610 4032 2461 3935 4322 M15920 GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT.html Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. 21/25 Gene Ontology BP GO:0061311 5.95729543636658e-06 7.01399181817148e-06 4280 3189.45454545455 3925 5.41573778905369e-07 1242 2.37180294719196 -2.15272785256868 -1 13.0798108401113 4279 2812 1634 1782 3925 4593 4434 4195 1242 1999 4189 4323 M11639 GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. 150/188 Gene Ontology BP GO:0034249 8.11254302578847e-08 2.36555650415222e-07 4240 3720.36363636364 3931 7.3750393863092e-09 1511 1.67702589470788 -1.60289442957829 -1 11.879414682686 4237 4115 3931 3830 1511 4560 4090 3647 3294 4243 3466 4324 M11710 GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHATIDYLINOSITOL_3_PHOSPHATE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. 33/53 Gene Ontology BP GO:0036092 2.31962908713249e-07 4.38927781310593e-07 4575 3289.45454545455 3932 2.10875393791714e-08 651 1.95486409685531 -2.00724434815902 -1 13.2998690868893 4571 3953 2583 3961 2414 4356 3932 2625 651 4044 3094 4325 M12136 GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_OXIDATIVE_PHOSPHORYLATION.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 16/22 Gene Ontology BP GO:0002082 0.000133857810537266 0.000140437518022525 4185 3505.45454545455 3933 1.21696323397464e-05 1338 1.30326551436005 -1.83845018528766 -1 5.30556424206717 2940 4273 3608 4183 4422 3933 4182 1338 4108 3882 1691 4326 M12437 GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of granulocyte differentiation. 15/21 Gene Ontology BP GO:0030852 7.41263234576645e-05 7.90896085871389e-05 3920 3767.81818181818 3933 6.73898374288833e-06 1674 1.43892652501963 -1.6788635459767 -1 6.25685542041511 3920 4280 3468 4414 4348 4523 3933 1674 4559 3118 3209 4327 M10731 GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MRNA_PROCESSING.html Any process that activates or increases the frequency, rate or extent of mRNA processing. 46/61 Gene Ontology BP GO:0050685 1.47236731234227e-05 1.66365349789427e-05 2535 3380.72727272727 3934 1.33852469669882e-06 2009 1.10141546484814 1.17693701152157 1 5.56754001302498 2532 4444 3934 4053 4094 2075 2009 2893 4422 4410 2322 4328 M12787 GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. 19/20 Gene Ontology BP GO:0000466 0.000275517895159989 0.000285838297921835 655 2999.81818181818 3936 2.50502187096894e-05 242 0.72318118966197 0.72318118966197 1 2.6528291210366 651 4529 3936 4247 4473 1412 242 2007 4445 4331 2725 4329 M14115 GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_SKELETAL_MUSCLE_ADAPTATION.html Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. 16/23 Gene Ontology BP GO:0014733 9.10876102498181e-07 1.30169118701598e-06 2965 3517.81818181818 3936 8.28069526938741e-08 2016 1.43596063972865 1.16019861447276 1 9.00784900011406 4308 2016 2961 2965 3224 4269 4078 3936 4009 2403 4527 4330 M14887 GO_INTERACTION_WITH_SYMBIONT http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERACTION_WITH_SYMBIONT.html An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. 52/80 Gene Ontology BP GO:0051702 6.19729021868626e-06 7.27997762876727e-06 3035 3854.63636363636 3936 5.63391606928401e-07 3033 1.51824517966586 -1.50653102987112 -1 8.30549743986459 3033 4436 3709 4591 3936 3607 4126 3593 4168 4097 3105 4331 M14439 GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_NUCLEOBASE_METABOLIC_PROCESS.html The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. 22/29 Gene Ontology BP GO:0006144 0.000145386860720285 0.000152258623212128 2685 3874.81818181818 3937 1.32178608627978e-05 2681 0.890327177101102 0.670783231206411 1 3.55494147928517 2681 4246 3937 4578 4429 3060 3577 3339 4592 4296 3888 4332 M12248 GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_PROTEIN_TRANSPORT_ER_TO_CYTOSOL.html The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. 19/22 Gene Ontology BP GO:0030970 2.29104214026215e-05 2.5321185459952e-05 1360 3143.18181818182 3938 2.08278727193507e-06 1103 0.733226169533051 -0.787148125315195 -1 3.52422084505824 1359 4242 3938 4438 4186 1993 1103 2198 4516 4330 2272 4333 M14464 GO_DSRNA_FRAGMENTATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DSRNA_FRAGMENTATION.html Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. 25/29 Gene Ontology BP GO:0031050 5.07309243668727e-07 7.99089340145764e-07 3390 3753.90909090909 3939 4.6119032786527e-08 2919 1.14742034945385 1.35672086274407 1 7.43751461705097 3388 3992 3804 4231 2919 3492 3061 4151 3939 4261 4055 4334 M10625 GO_POSITIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RNA_SPLICING.html Any process that activates or increases the frequency, rate or extent of RNA splicing. 30/44 Gene Ontology BP GO:0033120 0.000247316821639201 0.000256867225689107 3940 3783 3940 2.24858753241608e-05 2992 1.16332671388325 0.69779320976681 1 4.39450878367079 3940 3976 3744 2992 4468 3432 3338 3264 4204 4283 3972 4335 M13681 GO_ACROSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ACROSOME_ASSEMBLY.html The formation of the acrosome from the spermatid Golgi. 12/18 Gene Ontology BP GO:0001675 0.253321104995608 0.254304876277144 3840 4031.72727272727 3940 0.0262068482800447 3604 1.26594550418256 -0.983883560182146 -1 0.699335429773412 3838 4302 3604 4187 4614 3940 3877 3945 3873 3847 4322 4336 M16759 GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRODUCTION_OF_SMALL_RNA_INVOLVED_IN_GENE_SILENCING_BY_RNA.html The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. 25/29 Gene Ontology BP GO:0070918 5.07309243668727e-07 7.99089340145764e-07 3390 3753 3940 4.6119032786527e-08 2920 1.14742034945385 1.35672086274407 1 7.43751461705097 3389 3993 3805 4232 2920 3493 3062 4131 3940 4262 4056 4337 M11969 GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS.html The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. 497/647 Gene Ontology BP GO:0055086 5.07349573734859e-08 2.02998167617902e-07 3080 3469.81818181818 3941 4.61226895850021e-09 1023 1.62255505866576 -1.44011263267599 -1 11.6062365102909 3077 4324 4071 4034 1023 3214 3076 4015 3243 4150 3941 4338 M11907 GO_HISTONE_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_DEUBIQUITINATION.html The modification of histones by removal of ubiquitin groups. 23/27 Gene Ontology BP GO:0016578 3.2401037440087e-06 3.96846610183534e-06 3945 4014.18181818182 3942 2.94555319632771e-07 3244 0.744335423887456 0.731602075903823 1 4.22588393213389 3617 4499 3942 3565 3771 3941 3244 4644 4477 4312 4144 4339 M13544 GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ALTERNATIVE_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. 43/62 Gene Ontology BP GO:0000381 1.7260648273929e-05 1.9329412007778e-05 570 3125.81818181818 3942 1.56916215437583e-06 568 1.09411324909077 1.01973004823328 1 5.4529422322225 568 3942 3962 4213 4133 1900 1175 3401 4120 4138 2832 4340 M14488 GO_NEGATIVE_REGULATION_OF_JNK_CASCADE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_JNK_CASCADE.html Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade. 53/66 Gene Ontology BP GO:0046329 6.295917468564e-06 7.38651134171162e-06 3945 3928.18181818182 3942 5.72357771470098e-07 3287 1.69626564325637 -1.25055023678119 -1 9.28106193851616 3942 4425 3330 4248 3939 3511 4624 3287 3741 4047 4116 4341 M14428 GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. 27/35 Gene Ontology BP GO:0051569 1.59082475247502e-05 1.78924524371918e-05 4250 3708.72727272727 3943 1.44621477807239e-06 1961 1.07300950699714 -1.08723739414875 -1 5.38443232109026 4246 3720 3800 2651 4113 4064 3943 3511 1961 4202 4585 4342 M11336 GO_DNA_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_METHYLATION.html The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. 37/52 Gene Ontology BP GO:0006306 3.4393125451756e-06 4.18862836405224e-06 3945 4029.72727272727 3944 3.12665265631529e-07 3410 0.970016400133927 1.13792349420931 1 5.51690600325491 3818 3410 3943 4011 3792 4464 4579 4429 3944 4336 3601 4343 M16784 GO_DNA_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_ALKYLATION.html The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. 37/52 Gene Ontology BP GO:0006305 3.4393125451756e-06 4.18862836405224e-06 3945 4032.18181818182 3945 3.12665265631529e-07 3411 0.970016400133927 1.13792349420931 1 5.51690600325491 3819 3411 3944 4012 3793 4465 4580 4444 3945 4339 3602 4344 M10589 GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. 96/133 Gene Ontology BP GO:0032481 6.6465248428229e-06 7.78215402457347e-06 3605 3776.36363636364 3946 6.04231356640071e-07 2181 1.51634097588378 -1.50980222675998 -1 8.24753017744857 3605 4132 3764 4289 3946 3870 4213 2181 4194 4070 3276 4345 M12282 GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 172/233 Gene Ontology BP GO:0010822 1.04283329332334e-06 1.45671069163419e-06 3420 4004 3947 9.4803071603857e-08 3294 1.3134681687682 1.30816279012969 1 8.16053191599283 3416 4653 4079 4322 3294 3939 3947 3818 3656 4543 4377 4346 M12724 GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NATURAL_KILLER_CELL_ACTIVATION.html Any process that modulates the frequency, rate or extent of natural killer cell activation. 22/34 Gene Ontology BP GO:0032814 2.89991344703902e-07 5.16786567180105e-07 4030 3393.63636363636 3948 2.63628529935363e-08 1799 2.18208152430149 -1.32196703187795 -1 14.6918725489479 4029 2439 1927 3432 2570 4009 4612 4013 3948 1799 4552 4347 M11714 GO_PROTEIN_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_METHYLATION.html The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. 113/135 Gene Ontology BP GO:0006479 7.95189517357946e-06 9.23157890286058e-06 3415 3755.09090909091 3949 7.22902174166597e-07 2947 1.37835667088655 -1.63904647139602 -1 7.37638612781095 3414 4371 4066 4477 3981 3177 3380 3069 3949 4475 2947 4348 M11937 GO_CYTOCHROME_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOCHROME_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. 26/27 Gene Ontology BP GO:0017004 8.99750527982669e-05 9.54248547535459e-05 1020 3056.09090909091 3950 8.17988479875483e-06 678 0.845687387887528 -0.905135457353136 -1 3.55623491216525 1019 4222 3950 4252 4428 1893 2257 678 4493 4287 2138 4349 M16145 GO_PROTEIN_ALKYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ALKYLATION.html The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom. 113/135 Gene Ontology BP GO:0008213 7.95189517357946e-06 9.23157890286058e-06 4480 3731.09090909091 3950 7.22902174166597e-07 2795 1.37835667088655 -1.63904647139602 -1 7.37638612781095 3415 4372 4067 4478 3982 3178 3381 2795 3950 4476 2948 4350 M12278 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C.html The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. 13/17 Gene Ontology BP GO:0006122 0.594332919913863 0.595612982200992 3000 3857.18181818182 3952 0.0787466722118157 2592 0.705078501460487 -0.705078501460487 -1 0.0581417501275831 2998 4587 3952 3251 4649 3202 2592 3920 4614 4622 4042 4351 M10417 GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POLYSACCHARIDE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. 43/54 Gene Ontology BP GO:0000271 1.76673320140613e-07 3.65481746361674e-07 4025 3653.72727272727 3954 1.60612122116865e-08 2205 1.40569888721253 -1.12400727816444 -1 9.65251457033153 4022 4172 3682 4193 2205 4078 3866 2267 3954 4225 3527 4352 M11104 GO_ATP_GENERATION_FROM_ADP http://www.broadinstitute.org/gsea/msigdb/cards/GO_ATP_GENERATION_FROM_ADP.html The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. 34/54 Gene Ontology BP GO:0006757 5.17894452319386e-07 8.13284808181608e-07 4350 3930.72727272727 3955 4.7081324930471e-08 2929 1.26086153106521 -1.2306534931873 -1 8.17360938515186 4346 3697 3529 4522 2929 4046 3780 4205 3676 3955 4553 4353 M16138 GO_DEFINITIVE_HEMOPOIESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFINITIVE_HEMOPOIESIS.html A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. 17/21 Gene Ontology BP GO:0060216 0.000708722982383288 0.000728931926841167 3955 3833.72727272727 3955 6.44501271140747e-05 2820 1.96899227821694 -1.94825474122399 -1 6.55368764104245 3712 4535 2820 4141 4516 4391 4151 2862 3955 3951 3137 4354 M11466 GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_CLEAVAGE_INVOLVED_IN_RRNA_PROCESSING.html Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. 20/21 Gene Ontology BP GO:0000469 0.000180183706304241 0.000187938754860712 4450 3066.27272727273 3958 1.63816786677886e-05 413 0.679907772863058 0.691904113486339 1 2.6209466758287 923 4247 3958 4567 4448 1580 413 1920 4446 4355 2872 4355 M10781 GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ANAPHASE_PROMOTING_COMPLEX_DEPENDENT_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. 83/97 Gene Ontology BP GO:0031145 0.000497415154011051 0.000513300667911603 2725 3870.81818181818 3961 4.52297867357951e-05 2724 1.32168089197421 1.61838980976897 1 4.57922670814039 2724 4387 4069 3012 4496 4310 3961 3830 3523 4366 3901 4356 M14623 GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MONOCYTE_DIFFERENTIATION.html Any process that modulates the frequency, rate or extent of monocyte differentiation. 11/19 Gene Ontology BP GO:0045655 2.77447759868829e-06 3.44349006847069e-06 3965 3754.54545454545 3961 2.522255543328e-07 2342 1.62995456447457 1.44740662636358 1 9.49685825572768 3961 3550 3027 2909 3720 4241 4610 4318 3999 2342 4623 4357 M12417 GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS.html Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides. 22/29 Gene Ontology BP GO:0045978 2.41089543696767e-06 3.03925669688718e-06 4510 3653.54545454545 3963 2.19172552634488e-07 1675 1.29907839247372 -1.0753442774069 -1 7.6220971861569 4506 3742 3504 3999 3660 4598 3963 2426 4102 4014 1675 4358 M16816 GO_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_SPLICING.html Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 113/150 Gene Ontology BP GO:0043484 7.17524149908422e-06 8.36751846998468e-06 820 3306.72727272727 3963 6.52296809186402e-07 816 1.13898839583321 1.06775842954417 1 6.1282096279767 816 4368 4125 4064 3963 2237 1445 3496 4278 4411 3171 4359 M13830 GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ATP_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process. 22/29 Gene Ontology BP GO:1903579 2.41089543696767e-06 3.03925669688718e-06 4510 3668.18181818182 3964 2.19172552634488e-07 1676 1.29907839247372 -1.0753442774069 -1 7.6220971861569 4507 3743 3505 4000 3661 4599 3964 2577 4103 4015 1676 4360 M16777 GO_RESPONSE_TO_WATER_DEPRIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_WATER_DEPRIVATION.html Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. 12/17 Gene Ontology BP GO:0009414 3.53104739647223e-06 4.29653858153381e-06 4570 3971.81818181818 3964 3.21004823990192e-07 2935 1.21402613370546 -0.769183427284305 -1 6.91867186667633 4569 2935 3432 3964 3799 4436 4249 3325 4631 3848 4502 4361 M12337 GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS.html The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. 218/269 Gene Ontology BP GO:0015980 5.64969969607925e-08 2.06162496199217e-07 3610 3821.45454545455 3966 5.13609076469647e-09 1151 1.14296667584012 -0.865409315312468 -1 8.13399596932629 3609 4335 4202 4336 1151 3855 3776 3966 3913 4586 4307 4362 M12430 GO_DNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_MODIFICATION.html The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. 64/83 Gene Ontology BP GO:0006304 2.73616417772693e-07 4.93272836844766e-07 3730 3877.54545454545 3967 2.48742228911521e-08 2538 1.13931107080859 1.29522589299554 1 7.64175851188337 3727 4401 3967 4529 2538 4140 4105 3737 3265 4341 3903 4363 M11974 GO_PSEUDOURIDINE_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PSEUDOURIDINE_SYNTHESIS.html The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. 17/17 Gene Ontology BP GO:0001522 9.05192524338921e-07 1.29436411055593e-06 3970 3991.18181818182 3968 8.22902633437853e-08 3222 0.69427188516338 0.823058014876559 1 4.29862108902928 3968 4534 3911 4558 3222 3647 3226 3700 4579 4406 4152 4364 M14864 GO_ERROR_PRONE_TRANSLESION_SYNTHESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ERROR_PRONE_TRANSLESION_SYNTHESIS.html The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 21/25 Gene Ontology BP GO:0042276 1.60300798763041e-05 1.80120651206093e-05 3745 3877.18181818182 3968 1.45729060718807e-06 3213 1.09652356825374 1.02887989276846 1 5.50148152631885 3745 4002 3485 3504 4117 3622 3213 4161 4264 3968 4568 4365 M11015 GO_MRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_PROCESSING.html Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. 435/527 Gene Ontology BP GO:0006397 7.46899342302496e-06 8.69265292579669e-06 975 3395.18181818182 3970 6.79001707305075e-07 973 1.04905538693281 0.972612566326172 1 5.61666042239379 973 4619 4191 4646 3970 2242 1542 3270 4025 4612 3257 4366 M16841 GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. 20/24 Gene Ontology BP GO:0060260 0.00229195358634618 0.00233921036132239 2460 3499.63636363636 3970 0.00020857680229985 1692 0.802026227476068 0.811432985043597 1 2.16416215966068 2459 4546 3970 4587 4611 2469 2381 1692 4563 4358 2860 4367 M13579 GO_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR.html A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). 122/133 Gene Ontology BP GO:0006289 1.45313886571344e-05 1.64272476728975e-05 1805 3481.27272727273 3971 1.3210440582192e-06 1802 1.09876423307318 1.24405945413157 1 5.56038580416237 1802 4360 4159 4628 4092 2640 2293 2406 3971 4587 3356 4368 M16464 GO_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MANNOSYLATION.html The covalent attachment of a mannose residue to a substrate molecule. 29/31 Gene Ontology BP GO:0097502 1.10811018143417e-07 2.71799508392894e-07 2660 3427 3971 1.00737294295289e-08 1828 0.943907407806405 -0.715660908214285 -1 6.57539767268297 2657 3971 3933 4002 1828 2118 1876 4635 4041 4347 4289 4369 M14855 GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY.html Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. 28/30 Gene Ontology BP GO:0032878 5.20893437717936e-08 2.03844518708446e-07 2980 3336.18181818182 3973 4.73539500046471e-09 1052 1.49232954485281 -1.96464341188263 -1 10.66273803292 2978 3973 3508 4214 1052 4118 4389 1729 4285 4106 2346 4370 M10955 GO_GLUTAMATE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUTAMATE_METABOLIC_PROCESS.html The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. 23/33 Gene Ontology BP GO:0006536 6.15876401941434e-07 9.35709530577235e-07 4555 3471.09090909091 3974 5.59887794865722e-08 1801 2.38417236795376 -2.82002944976331 -1 15.3996017613329 4551 1927 1801 4352 3021 3974 4082 4376 2690 3407 4001 4371 M12504 GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY.html The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. 14/14 Gene Ontology BP GO:0000244 0.000186632349305335 0.000194534122158988 3480 3969.36363636364 3975 1.69680167042529e-05 3232 1.11802691079266 1.45877456570864 1 4.36463650647717 3478 4557 3817 4191 4450 3948 3975 4456 3379 4180 3232 4372 M12978 GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_T_HELPER_1_TYPE_IMMUNE_RESPONSE.html Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response. 5/26 Gene Ontology BP GO:0002827 1.4723593274808e-05 1.66365349789427e-05 3300 3831.27272727273 3975 1.47236908286072e-06 3019 1.7411100400036 -2.14007619076437 -1 8.86681556579202 3299 4081 4397 3688 4119 3975 4425 3539 4280 3322 3019 4373 M15352 GO_TROPHECTODERMAL_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TROPHECTODERMAL_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. 10/14 Gene Ontology BP GO:0001829 8.40851643837587e-07 1.2135492241862e-06 3965 3865.45454545455 3975 7.64410877468826e-08 2528 0.998935796301389 -1.16871471679212 -1 6.26477921887633 3965 4309 3536 3773 3190 4051 3978 4645 4570 3975 2528 4374 M16175 GO_IMP_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_IMP_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. 10/11 Gene Ontology BP GO:0006188 0.00117892655676708 0.00120960204380093 3325 3887 3976 0.000107232617203456 2970 1.38047079429853 -1.26954221287203 -1 4.23332019097486 3324 4073 3499 2970 4527 3518 4423 4402 3765 3976 4280 4375 M10901 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. 24/29 Gene Ontology BP GO:2000144 0.0486768270666234 0.0491308625468544 2250 3586 3977 0.00452622108682842 2111 0.826650650239547 0.816309813669282 1 1.0544071043275 2249 4511 3977 4283 4623 2787 2111 2768 4578 4228 3331 4376 M12311 GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_NUCLEUS_TRANSLOCATION.html A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope. 28/50 Gene Ontology BP GO:0000060 0.000151445691986856 0.000158532464525274 3880 3996.72727272727 3979 1.37687380322056e-05 3221 1.57268190219688 -2.51514310426667 -1 6.33639538457836 3878 4482 3315 4564 4432 3871 3662 3979 4234 4326 3221 4377 M14381 GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. 476/602 Gene Ontology BP GO:0022613 7.27916563734059e-06 8.48445834432509e-06 1755 3717.36363636364 3979 6.61744520192029e-07 1751 0.863974286663761 0.795138012401777 1 4.61559644420415 1751 4618 4210 4350 3965 2944 2426 3530 4484 4634 3979 4378 M15653 GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_DAMAGE_RESPONSE_DETECTION_OF_DNA_DAMAGE.html The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. 42/47 Gene Ontology BP GO:0042769 8.37395025559997e-05 8.90198550132663e-05 2290 3712.45454545455 3979 7.61297183062758e-06 2288 0.92668335612626 0.966968596963178 1 3.93784418258669 2288 4453 3979 4280 4363 3130 2977 2748 4502 4412 3705 4379 M11010 GO_NEGATIVE_REGULATION_OF_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_RNA_SPLICING.html Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. 34/50 Gene Ontology BP GO:0033119 4.65034520170469e-05 5.01461326153694e-05 4190 3222.81818181818 3980 4.22767591208892e-06 771 0.966119026004791 0.869252090356683 1 4.3701188280671 1321 4190 3980 4036 4297 2042 771 2792 4357 4189 3476 4380 M10813 GO_COENZYME_A_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_METABOLIC_PROCESS.html The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 17/17 Gene Ontology BP GO:0015936 1.35149525567882e-06 1.81853887353196e-06 4565 3832.54545454545 3982 1.22863280538611e-07 3000 1.20110326922398 -1.48378209085447 -1 7.32784287184769 4563 4028 3562 3520 3426 3982 3000 4209 4023 3694 4151 4381 M11249 GO_SUPEROXIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SUPEROXIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. 47/78 Gene Ontology BP GO:0006801 5.94634491454924e-06 7.00490649384619e-06 4600 3654.09090909091 3982 5.40578271535536e-07 2202 2.1919433337207 -2.38699716804005 -1 12.080691981253 4596 4166 2202 4525 3922 4313 4468 2308 3982 2817 2896 4382 M12046 GO_CELLULAR_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). 147/171 Gene Ontology BP GO:0045333 0.111810682077962 0.112536254317274 2420 3858.81818181818 3983 0.0107212373154794 2420 1.09951330235844 -0.877925660182578 -1 1.0126665525776 2420 4118 4183 4325 4604 3449 3142 3892 3755 4576 3983 4383 M11867 GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMMONIUM_TRANSMEMBRANE_TRANSPORT.html The directed movement of ammonium across a membrane by means of some agent such as a transporter or pore. Ammonium is the cation NH4+. 23/52 Gene Ontology BP GO:0072488 9.42009319061758e-05 9.96627867574889e-05 4550 3907.81818181818 3986 8.56408779095642e-06 2683 2.11044075239327 -1.65606860135904 -1 9.0008599633429 4547 3986 2683 3921 4383 4602 4192 4532 3532 3099 3509 4384 M14514 GO_MEGAKARYOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MEGAKARYOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. 22/26 Gene Ontology BP GO:0030219 1.73800345435355e-06 2.26397818396054e-06 4010 3555.72727272727 3986 1.58000438852775e-07 2243 1.72763011182835 -1.82977702368541 -1 10.4123153036295 4007 4221 2921 4184 3542 3986 4133 2397 4186 3293 2243 4385 M11252 GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERE_LENGTHENING.html Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. 26/35 Gene Ontology BP GO:0010833 0.000166068075202183 0.000173526780578432 785 2913 3987 1.50982374779031e-05 105 0.858854559655825 0.929008848877866 1 3.37264432236971 781 4489 3987 4266 4441 1028 105 1827 4365 4375 2379 4386 M13938 GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_MAINTENANCE_VIA_TELOMERASE.html The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. 18/18 Gene Ontology BP GO:0007004 0.00176526771046269 0.00180681712643706 1695 3213.63636363636 3988 0.000160607794965467 361 0.656746433626363 0.717993255190282 1 1.83115058338152 1691 4555 3988 4271 4536 1611 361 2479 4562 4418 2878 4387 M15413 GO_NUCLEAR_EXPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_EXPORT.html The directed movement of substances out of the nucleus. 177/222 Gene Ontology BP GO:0051168 8.26612715730719e-06 9.57964873298888e-06 895 3212.72727272727 3988 7.51468928731134e-07 892 0.909589756728548 0.848869154131802 1 4.81350014303604 892 4113 4212 4338 3988 1825 1004 2847 4366 4644 3111 4388 M12178 GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 27/29 Gene Ontology BP GO:0034243 2.34841307437898e-07 4.41501657983249e-07 3535 3725.18181818182 3992 2.13492120460258e-08 2428 0.777787548296993 -0.75936651615043 -1 5.22142750209055 3533 4200 3992 4227 2428 3367 2726 4051 4298 4396 3759 4389 M11223 GO_HOMEOSTATIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HOMEOSTATIC_PROCESS.html Any biological process involved in the maintenance of an internal steady state. 1241/1868 Gene Ontology BP GO:0042592 2.83877166436295e-08 1.97691467186943e-07 4535 2879.81818181818 3995 2.83877170062676e-09 162 2.17310116672568 -1.99234989802576 -1 15.6096823182226 4535 1160 4287 1093 454 4647 4455 4438 2452 162 3995 4390 M12077 GO_NEGATIVE_REGULATION_OF_DNA_BINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_BINDING.html Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). 66/89 Gene Ontology BP GO:0043392 8.65702465053929e-05 9.19240887698752e-05 3750 3952.72727272727 3995 7.87033211290655e-06 2926 1.77537632289569 -1.58997057189774 -1 7.62114131859065 3749 4408 2926 4442 4369 3809 4577 3995 4073 3415 3717 4391 M13959 GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE.html Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. 20/23 Gene Ontology BP GO:1900103 3.45779463883021e-05 3.75913982581238e-05 4595 3977 3995 3.14349907913019e-06 2938 0.967576951798203 0.836555760310188 1 4.50756973701108 4212 3756 3615 3245 4260 3995 2938 4591 4593 3920 4622 4392 M11321 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION_3_TO_LESION.html The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. 23/23 Gene Ontology BP GO:0006295 0.0440318724734512 0.0444618712280747 2980 3749.72727272727 3996 0.00408533276604442 2419 0.755415472604792 0.799147025629307 1 0.989154866885552 2980 4501 3996 4454 4616 3084 2419 2722 4507 4473 3495 4393 M14289 GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOSIDE_TRANSMEMBRANE_TRANSPORT.html The directed movement of nucleoside across a membrane. 10/13 Gene Ontology BP GO:1901642 1.07676981390577e-07 2.67782466280255e-07 4000 3404.90909090909 3996 9.78881696915715e-09 790 1.44352812070136 -1.86714625918996 -1 10.1257670349305 3996 2945 3040 4123 1803 4390 4581 790 4321 3208 4257 4394 M16455 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_STABILIZATION.html The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 23/23 Gene Ontology BP GO:0006293 0.0513621919333786 0.0518300323283475 2985 3756.45454545455 3997 0.00478200324324609 2420 0.755415472604792 0.799147025629307 1 0.934863108492401 2981 4502 3997 4455 4617 3085 2420 2786 4508 4474 3496 4395 M12563 GO_RNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_MODIFICATION.html The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. 114/121 Gene Ontology BP GO:0009451 2.9558045936917e-06 3.6442392089156e-06 3310 3863.09090909091 3999 2.68709869542106e-07 2367 0.943441682977756 0.905228604493727 1 5.42423049322318 3310 4362 4173 4609 3745 3217 2367 3928 4220 4564 3999 4396 M14416 GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_DAMAGE_CHECKPOINT.html Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. 18/18 Gene Ontology BP GO:2000001 9.42659164797649e-07 1.33970467129e-06 4005 3733.45454545455 4000 8.56963244281679e-08 1826 1.11154614163509 0.994539779550912 1 6.93223378185282 4003 4519 3723 4411 3243 4107 4228 1826 3863 4000 3145 4397 M10148 GO_STRESS_FIBER_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_STRESS_FIBER_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity. 21/22 Gene Ontology BP GO:0043149 3.85567599754321e-05 4.17511296638784e-05 3055 3807.36363636364 4003 3.50522143000691e-06 2986 1.70741277926353 -1.66221620059354 -1 7.95666903322353 4351 4003 3054 2986 4275 4182 4324 3562 3052 3754 4338 4398 M11272 GO_RRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. 279/371 Gene Ontology BP GO:0016072 8.94598967031293e-06 1.03340838967145e-05 1980 3736 4003 8.13275095284101e-07 1978 0.836703973530996 0.801791950072071 1 4.38900109542278 1978 4642 4196 4349 4003 3025 2327 3453 4583 4616 3924 4399 M11075 GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY.html Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. 21/22 Gene Ontology BP GO:0030038 3.85567599754321e-05 4.17511296638784e-05 3055 3821.54545454545 4004 3.50522143000691e-06 2987 1.70741277926353 -1.66221620059354 -1 7.95666903322353 4352 4004 3055 2987 4276 4183 4325 3707 3053 3756 4339 4400 M13058 GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING.html Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling. 42/62 Gene Ontology BP GO:0032007 2.00887575313394e-06 2.57501346538078e-06 3935 3870.27272727273 4004 1.82625235226513e-07 2112 1.09668080665725 -0.94293919164458 -1 6.50214971468201 3582 3931 3935 4456 3596 4057 4004 4418 4378 4104 2112 4401 M11776 GO_CRISTAE_FORMATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CRISTAE_FORMATION.html The assembly of cristae, the inwards folds of the inner mitochondrial membrane. 12/13 Gene Ontology BP GO:0042407 0.654129210153737 0.654973792736247 3160 4046.45454545455 4005 0.0920057871799646 3156 0.799811198429365 -0.86956836810901 -1 0.0455344141949206 3156 4585 3863 4235 4645 3991 3486 3784 4467 4294 4005 4402 M15487 GO_RNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an RNA molecule. 109/144 Gene Ontology BP GO:0031123 8.9843734593546e-06 1.03732850528953e-05 1725 3633.72727272727 4005 8.16764559091243e-07 1721 0.715430145603469 0.699184283703715 1 3.73518677384208 1721 4378 4214 4632 4005 2500 2118 3746 4542 4595 3520 4403 M13474 GO_RNA_DESTABILIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DESTABILIZATION.html Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. 21/23 Gene Ontology BP GO:0050779 4.63324976580316e-07 7.44938187984869e-07 4305 3927.09090909091 4007 4.21204612870576e-08 2858 1.20561015432674 -1.51384485127867 -1 7.8600854111806 4305 4007 3769 3546 2858 4456 4047 4123 3761 3967 4359 4404 M15645 GO_PROTEIN_K48_LINKED_UBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_UBIQUITINATION.html A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. 52/61 Gene Ontology BP GO:0070936 2.25342161654269e-06 2.85933209211158e-06 4160 3954.45454545455 4008 2.04856720426041e-07 2973 1.20133191163424 1.06787608543157 1 7.07443962550961 4159 3373 3976 3764 3637 4357 4196 4448 2973 4008 4608 4405 M12372 GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS.html The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. 44/55 Gene Ontology BP GO:0006220 1.16418104487191e-06 1.60027604188744e-06 4590 3770.18181818182 4009 1.05834696447798e-07 2311 1.19494736052961 1.26102430076773 1 7.36131635629088 4103 2311 3686 4381 3351 4589 4239 4009 2963 3251 4589 4406 M12117 GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ANDROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway. 29/35 Gene Ontology BP GO:0060765 6.15549192953597e-08 2.12002249801117e-07 4050 3694.54545454545 4010 5.59590191069419e-09 1243 1.27815404338668 -1.2144455467982 -1 9.09270897610123 4047 3712 3811 2666 1243 4233 4599 4010 3976 4144 4199 4407 M14724 GO_UBIQUINONE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UBIQUINONE_METABOLIC_PROCESS.html The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme. 13/13 Gene Ontology BP GO:0006743 7.79406921881171e-06 9.05513210365316e-06 4075 4069.81818181818 4012 7.08554257405044e-07 3439 0.710295080186773 -0.706588283424147 -1 3.75280965338828 4071 4290 3818 4001 3978 4012 3805 3439 4541 4635 4178 4408 M16400 GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_EXIT_FROM_ENDOPLASMIC_RETICULUM.html The directed movement of proteins from the endoplasmic reticulum. 24/29 Gene Ontology BP GO:0032527 0.000102103062854881 0.000107851430525258 1220 3313 4014 9.28252743775195e-06 1216 0.73524386329077 -0.783847055238583 -1 3.03484830516796 1216 4500 4014 4458 4390 2146 1584 2459 4558 4420 2698 4409 M12546 GO_ER_NUCLEUS_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_ER_NUCLEUS_SIGNALING_PATHWAY.html Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. 46/50 Gene Ontology BP GO:0006984 9.24017959374326e-08 2.50183514628907e-07 4015 3506.45454545455 4015 8.40016361985306e-09 1650 1.64416907567947 1.72588118101332 1 11.6012897332001 4015 2714 3188 2046 1650 4197 4521 4517 2953 4209 4561 4410 M16453 GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION.html The alteration of the N-terminal amino acid residue in a protein. 22/27 Gene Ontology BP GO:0031365 0.0464812751703954 0.0469250104942178 3015 3920.27272727273 4015 0.00431758107075535 2323 0.643599505227118 0.60780906863449 1 0.809735333255181 3012 4520 4015 4282 4595 3380 2323 3932 4598 4469 3997 4411 M11930 GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. 25/29 Gene Ontology BP GO:0045947 0.00202829465943771 0.00207193305167149 4640 3944.18181818182 4016 0.000184560642474482 2078 0.915572773140263 -1.05806036576706 -1 2.53863161565001 4636 4504 4016 3831 4544 3878 2078 3248 4498 4433 3720 4412 M16096 GO_RNA_SPLICING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING.html The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. 384/464 Gene Ontology BP GO:0008380 9.50056374595698e-06 1.09339903808899e-05 985 3427.27272727273 4016 8.63691343072832e-07 982 0.969700168236452 0.927184958053351 1 5.07897396079204 982 4628 4218 4645 4016 2265 1443 3353 4246 4649 3255 4413 M16744 GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SINGLE_ORGANISM_CELLULAR_LOCALIZATION.html A cellular localization which involves only one organism. 1005/1309 Gene Ontology BP GO:1902580 4.0183030679522e-08 1.97691467186943e-07 4560 3434.45454545455 4016 4.01830314061261e-09 857 1.8068237339084 -1.54442170571633 -1 12.9595988415626 4559 2591 4645 2552 857 3724 4016 4536 1858 4212 4229 4414 M12202 GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_STARVATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. 8/10 Gene Ontology BP GO:0006995 1.99136884204823e-07 3.96654076286404e-07 3885 3859.90909090909 4018 1.99136902049799e-08 2380 0.763573519719756 -0.689665584976045 -1 5.16227552106039 3882 4075 4355 4391 2380 3457 3154 4500 4018 3801 4446 4415 M14031 GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_NITROGEN_LEVELS.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. 8/10 Gene Ontology BP GO:0043562 1.99136884204823e-07 3.96654076286404e-07 3885 3870.45454545455 4019 1.99136902049799e-08 2381 0.763573519719756 -0.689665584976045 -1 5.16227552106039 3883 4076 4468 4392 2381 3458 3155 4493 4019 3803 4447 4416 M10234 GO_NUCLEOTIDE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_PHOSPHORYLATION.html The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. 52/76 Gene Ontology BP GO:0046939 2.00126487320528e-07 3.97760141854629e-07 4060 3716.45454545455 4022 1.81933186841231e-08 2299 1.36031397990503 -1.15900854376786 -1 9.28325782874584 4060 3376 3520 4142 2299 4314 4022 4272 2892 3767 4217 4417 M11415 GO_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELL_ACTIVATION.html A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. 561/883 Gene Ontology BP GO:0001775 4.99443292422428e-08 2.02079099099266e-07 4330 2854.45454545455 4022 4.99443303647389e-09 231 2.19536825827678 -1.91534997281726 -1 15.7482009963629 4328 1242 4300 913 1118 4334 4115 4022 2283 231 4513 4418 M10943 GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_CHROMOSOME.html The directed movement of a protein to a specific location on a chromosome. 17/20 Gene Ontology BP GO:0070199 1.74439387839535e-05 1.95252940008986e-05 3645 3896.81818181818 4023 1.5858251908709e-06 3032 1.82767390613697 0.945556557938146 1 9.17611953969352 3644 4023 3032 4400 4135 3771 4124 4464 3506 3381 4385 4419 M14820 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. 36/39 Gene Ontology BP GO:0006360 9.72875488482838e-06 1.11744992542845e-05 1935 3340.54545454545 4024 8.84436173383472e-07 1732 0.823979362311072 0.844267010975767 1 4.2903371423754 1932 4461 4064 4590 4024 2283 1732 2066 4407 4446 2741 4420 M13231 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. 31/36 Gene Ontology BP GO:2000142 0.0119001781256397 0.0120503871204791 2365 3594.36363636364 4027 0.0010877309052298 2362 0.796055968552877 0.783422678045112 1 1.5355693610442 2362 4484 4027 4295 4580 2665 2412 2514 4581 4384 3234 4421 M14131 GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. 18/23 Gene Ontology BP GO:1903019 4.48984290603978e-08 1.97691467186943e-07 4410 3422.36363636364 4027 4.08167545242743e-09 891 1.71216126010619 -1.45436534448701 -1 12.2746987215813 4410 1991 2720 4370 891 4388 4027 4251 4465 2764 3369 4422 M15747 GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION.html Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. 11/18 Gene Ontology BP GO:2000515 1.869973382947e-05 2.08756865423522e-05 4035 3808.72727272727 4032 1.69999025243969e-06 3104 1.56199237977239 0.84706640790729 1 7.77682420377685 4182 3561 3104 3207 4148 4258 3354 4035 3783 4032 4232 4423 M12659 GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MODULATION_OF_TRANSCRIPTION_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. 24/31 Gene Ontology BP GO:0052312 2.56588048656344e-05 2.82323960641852e-05 4240 3704.90909090909 4034 2.33264583014104e-06 2482 1.51337176582851 -1.10757691410121 -1 7.31709800486229 4236 4213 3349 4207 4205 4351 4034 2482 2846 3519 3312 4424 M13263 GO_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 20/21 Gene Ontology BP GO:0090140 7.82178469519453e-05 8.32641596585224e-05 3660 3956.45454545455 4036 7.11096618307453e-06 2911 1.58793290801516 1.84915835236214 1 6.87820575002016 3660 4513 3483 4437 4356 3689 2911 3908 4295 4233 4036 4425 M12124 GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT.html The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. 35/40 Gene Ontology BP GO:0060674 1.17426238079874e-06 1.61096475569977e-06 4415 4103.63636363636 4038 1.06751182506215e-07 3355 1.21125305881333 1.20561403923334 1 7.45952939120427 4411 3702 3751 4038 3355 4604 4635 3882 4282 3854 4626 4426 M10934 GO_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_METHYLATION.html The modification of histones by addition of methyl groups. 81/94 Gene Ontology BP GO:0016571 1.03615812306174e-05 1.18632966205863e-05 4040 4086.54545454545 4040 9.41966366546764e-07 3403 1.38645331066237 -1.50645878390845 -1 7.25738878577941 3972 4396 4013 4474 4040 4037 4106 3403 3961 4464 4086 4427 M14315 GO_NON_RECOMBINATIONAL_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NON_RECOMBINATIONAL_REPAIR.html A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA. 63/88 Gene Ontology BP GO:0000726 2.15312360892886e-06 2.74362061930007e-06 4040 3927.72727272727 4040 1.95738701470707e-07 3229 1.12625500296369 -1.13219045692395 -1 6.64706299583168 4038 4151 4078 4288 3621 3466 3229 3715 4040 4416 4163 4428 M14695 GO_HISTONE_H2A_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H2A_ACETYLATION.html The modification of histone H2A by the addition of an acetyl group. 16/18 Gene Ontology BP GO:0043968 1.41099210365572e-05 1.59585470547158e-05 2865 3362.63636363636 4040 1.28272832116055e-06 810 0.704284979065079 0.739478696494869 1 3.53304241226745 2862 4278 3914 4045 4090 1930 810 4040 4642 4389 1989 4429 M15433 GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CHROMATIN_MODIFICATION.html Any process that stops, prevents or reduces the frequency, rate or extent of chromatin modification. 53/71 Gene Ontology BP GO:1903309 3.13319771379942e-05 3.41583152818854e-05 1475 3256.72727272727 4041 2.84840212462614e-06 1471 1.05871247712642 1.30525664248365 1 4.99031067393442 1471 4427 4041 4253 4247 2432 2237 2258 4064 4440 1954 4430 M10089 GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_DEPENDENT_DNA_BIOSYNTHETIC_PROCESS.html A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. 24/26 Gene Ontology BP GO:0006278 0.0687187966564762 0.0692546157337197 1940 3502.72727272727 4043 0.00645128262437072 1342 0.659359882448955 0.678062694297214 1 0.712041258222554 1940 4521 4043 4594 4602 2004 1342 3056 4616 4483 3329 4431 M15577 GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY http://www.broadinstitute.org/gsea/msigdb/cards/GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY.html The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. 282/364 Gene Ontology BP GO:0006091 4.62400271693163e-08 1.97760774550163e-07 3305 3678 4045 4.2036389219271e-09 934 1.2267604489031 -0.982243869752096 -1 8.76253451000252 3304 4330 4215 4340 934 3547 3524 3569 4045 4584 4066 4432 M12841 GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_INNER_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. 18/19 Gene Ontology BP GO:0007007 0.419947742967903 0.421033580700206 3240 4006.63636363636 4046 0.0483067018674292 3175 0.727337389709987 -0.785316598767625 -1 0.181800685281174 3238 4542 3953 4046 4622 3932 3175 3607 4452 4417 4089 4433 M14472 GO_NUCLEAR_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_IMPORT.html The directed movement of substances into the nucleus. 137/180 Gene Ontology BP GO:0051170 2.44697397054621e-06 3.07723510404095e-06 2455 3518.90909090909 4048 2.2245242656581e-07 1365 1.29074078715607 0.987911902603531 1 7.56493908519426 2455 4119 4085 3843 3670 2227 1365 4250 4048 4485 4161 4434 M16483 GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMINO_ACID_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. 59/79 Gene Ontology BP GO:0006521 0.123977062012928 0.124700663542186 1535 3486.72727272727 4050 0.0119608932784393 1533 1.13557757510018 -1.10081672026802 -1 0.994961319075626 1533 4421 4093 4290 4608 2572 2044 3244 4050 4324 3175 4435 M13065 GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_EARLY_ENDOSOME_TO_LATE_ENDOSOME_TRANSPORT.html Any process that modulates the frequency, rate or extent of early endosome to late endosome transport. 19/19 Gene Ontology BP GO:2000641 2.78621359050587e-06 3.45713382309968e-06 4590 3998.54545454545 4051 2.53292465376564e-07 2990 1.06900350686484 -0.975038070559239 -1 6.18759766515905 4588 3760 3809 2990 3721 4633 4156 4255 3679 4051 4342 4436 M14732 GO_HISTONE_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving an mRNA encoding a histone. 28/31 Gene Ontology BP GO:0008334 0.0002174864493912 0.00022639025705084 2220 3711.36363636364 4051 1.97734502299065e-05 2073 0.721541929596239 0.751640436853602 1 2.7254138406236 2220 4486 4051 4588 4459 2736 2073 3615 4548 4506 3543 4437 M11962 GO_RESPONSE_TO_NERVE_GROWTH_FACTOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_RESPONSE_TO_NERVE_GROWTH_FACTOR.html A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. 50/59 Gene Ontology BP GO:1990089 1.21907760570884e-07 2.8768778197501e-07 4355 3751.81818181818 4053 1.10825243023739e-08 1911 1.39971058227847 -1.36847352320567 -1 9.7679323080071 4354 4163 3551 3224 1911 4352 4383 4624 3166 4053 3489 4438 M15661 GO_MATURATION_OF_5_8S_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_5_8S_RRNA.html Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. 28/29 Gene Ontology BP GO:0000460 0.000242566536365789 0.000252046023606524 4465 3172.09090909091 4055 2.20539350253408e-05 649 0.735468271328057 0.735468271328057 1 2.74319354103286 736 4496 4055 4595 4465 1687 649 2233 4524 4462 2991 4439 M10426 GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE.html A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. 80/93 Gene Ontology BP GO:0036498 7.15385339774322e-08 2.23824899990528e-07 3340 3516.45454545455 4056 6.50350330033523e-09 1395 0.829715496758248 -0.784548823636457 -1 5.84176064884282 3336 4388 4145 4608 1395 2454 1775 4056 4447 4511 3566 4440 M15649 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DUPLEX_UNWINDING.html The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage. 25/29 Gene Ontology BP GO:0000717 0.330136492139276 0.331275630348081 3120 3988.09090909091 4057 0.0357701443860039 2956 0.587108990363171 -0.529989808756249 -1 0.19092297544884 3120 4516 4057 4301 4620 3125 2956 3951 4643 4646 3934 4441 M11982 GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4 http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. 37/45 Gene Ontology BP GO:0071353 4.31281589396973e-06 5.17204442129927e-06 4465 3968 4058 3.92074940791958e-07 2789 1.83578150573728 1.34811878113564 1 10.3603701376268 4465 4456 2789 4152 3856 4529 4554 3331 3689 4058 3769 4442 M14625 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_INCISION.html A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. 43/47 Gene Ontology BP GO:0033683 0.000803638609736768 0.000826006284759262 2705 3869.72727272727 4058 7.30847564840191e-05 2703 0.744659818694626 0.816285879427763 1 2.36460045927948 2703 4452 4095 4058 4519 3330 2821 3486 4591 4545 3967 4443 M12862 GO_PROTEIN_O_LINKED_MANNOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_O_LINKED_MANNOSYLATION.html The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. 16/16 Gene Ontology BP GO:0035269 1.1573800631306e-06 1.59233868531836e-06 4065 3918.36363636364 4062 1.05216424727972e-07 2879 0.891145685506445 1.05740211266237 1 5.463109090255 4062 3785 3815 4408 3347 3302 2879 4454 4198 4249 4603 4444 M14372 GO_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that modulates the frequency, rate or extent of the transcription of the viral genome. 70/86 Gene Ontology BP GO:0046782 3.82690102214681e-05 4.14684919796206e-05 4280 3948.63636363636 4063 3.47906144793552e-06 3243 1.10617034966027 1.07997012263162 1 5.11853103523367 3580 4149 4053 4276 4273 3243 3422 4014 4063 4280 4082 4445 M14939 GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION_IN_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. 15/15 Gene Ontology BP GO:0043558 4.39515301009627e-05 4.74492968816194e-05 4565 3953.27272727273 4063 3.99567347161764e-06 2633 0.979701727028443 -1.14338239554918 -1 4.45853242661769 3544 4564 3838 4563 4292 4063 4007 2633 4543 4217 3222 4446 M10780 GO_PROTEIN_N_LINKED_GLYCOSYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_N_LINKED_GLYCOSYLATION.html A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. 67/81 Gene Ontology BP GO:0006487 1.93364106617603e-08 1.97691467186943e-07 4600 3683.36363636364 4065 1.75785553015575e-09 111 1.40894698463425 -1.11404969249715 -1 10.0808885948283 4600 4148 3730 4155 111 3947 3741 4369 3077 4065 4574 4447 M12478 GO_NCRNA_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_TRANSCRIPTION.html The transcription of non (protein) coding RNA from a DNA template. 92/106 Gene Ontology BP GO:0098781 1.23762157971063e-05 1.40936201918589e-05 3445 3888.18181818182 4065 1.125116856428e-06 2641 1.1307375944963 0.938211153581553 1 5.80668400833826 3443 4384 4091 4610 4065 3417 3660 4077 2641 4541 3841 4448 M13429 GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT.html The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 202/268 Gene Ontology BP GO:0015931 3.32252478676615e-06 4.06299811637921e-06 2145 3630.90909090909 4065 3.02048164052886e-07 1829 1.12460215125881 0.896257742936248 1 6.43017775967162 2141 4336 4177 4065 3777 2555 1829 4391 3819 4565 4285 4449 M16277 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_EXONUCLEOLYTIC.html The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. 32/34 Gene Ontology BP GO:0000291 0.00174492229663625 0.00178638579675434 3120 4039.54545454545 4065 0.000158755255852379 3119 0.974072573261552 1.23394592403351 1 2.77576273844926 3119 4483 4047 4284 4535 3763 3878 3424 4437 4400 4065 4450 M14704 GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE.html The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. 45/50 Gene Ontology BP GO:0006120 0.217490860839857 0.218429737856217 1105 3597.18181818182 4066 0.0220487190814457 1104 0.871929635462549 -0.881913394103534 -1 0.508619138866131 1104 4463 4127 4066 4627 2898 1904 3585 4573 4522 3700 4451 M16023 GO_RNA_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_LOCALIZATION.html A process in which RNA is transported to, or maintained in, a specific location. 190/248 Gene Ontology BP GO:0006403 1.67259623525695e-05 1.87577495363957e-05 1240 3434.90909090909 4067 1.52055359241517e-06 1240 0.978081611609148 0.773232618438295 1 4.87642149290487 1240 4340 4217 4074 4126 2196 1330 3850 4067 4607 3737 4452 M10252 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_BIOGENESIS.html The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together. 62/67 Gene Ontology BP GO:0097031 0.345990612726615 0.347109599184334 1660 3715.63636363636 4068 0.0378674502275206 1658 0.887941224981596 -0.94231673279998 -1 0.32727045169835 1658 4433 4155 4068 4624 3167 2513 3470 4520 4526 3738 4453 M16641 GO_PROTEOLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEOLYSIS.html The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. 1051/1543 Gene Ontology BP GO:0006508 3.15493583944048e-08 1.97691467186943e-07 3980 3573.09090909091 4068 3.15493588423176e-09 578 1.91107328220984 -1.64598722739089 -1 13.7138631796026 3978 4087 4641 4502 578 3445 3768 4095 1913 4229 4068 4454 M13411 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_I_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. 62/67 Gene Ontology BP GO:0032981 0.36176664016199 0.362858412734154 1660 3717.72727272727 4069 0.0400008164377698 1659 0.887941224981596 -0.94231673279998 -1 0.308803575431616 1659 4434 4156 4069 4625 3168 2514 3483 4521 4527 3739 4455 M15064 GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. 62/67 Gene Ontology BP GO:0010257 0.374179618131344 0.375227966199384 1660 3720.18181818182 4070 0.041713372984928 1660 0.887941224981596 -0.94231673279998 -1 0.294852726793337 1660 4435 4157 4070 4626 3169 2515 3500 4522 4528 3740 4456 M15325 GO_COENZYME_A_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_COENZYME_A_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. 11/11 Gene Ontology BP GO:0015937 0.00869117009698992 0.00881814532518405 3905 4077 4070 0.00079324508605491 3612 1.08785323459076 0.997723582094442 1 2.29912282070154 3905 4070 3612 3755 4571 4048 4493 4199 4360 3744 4090 4457 M16609 GO_SPLICEOSOMAL_SNRNP_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_SNRNP_ASSEMBLY.html The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. 39/45 Gene Ontology BP GO:0000387 1.37851426640836e-05 1.5613989487824e-05 1045 3314.27272727273 4070 1.25320264019872e-06 1042 0.815868176503228 0.840260146503177 1 4.11906438805988 1042 4454 4070 4457 4085 1991 1664 2856 4371 4424 3043 4458 M11099 GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. 84/89 Gene Ontology BP GO:0033108 0.0864975674998037 0.0871342674987197 1050 3545.54545454545 4071 0.00819074791754761 1050 0.931122216158457 -0.992506781651307 -1 0.951902600437743 1050 4404 4172 4071 4641 2921 2298 2976 4478 4544 3446 4459 M13872 GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. 220/242 Gene Ontology BP GO:0061136 1.22843182619622e-07 2.88827351555887e-07 1920 3674.54545454545 4072 1.11675626799015e-08 1918 1.43477298538428 1.51089101907383 1 10.0127911222105 3791 4331 4072 4268 1918 3576 3398 4192 1918 4397 4559 4460 M12532 GO_SECRETORY_GRANULE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SECRETORY_GRANULE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. 33/40 Gene Ontology BP GO:0033363 4.04424552186855e-06 4.87131100524317e-06 4520 4104.72727272727 4073 3.6765935967251e-07 3564 1.53315849823476 -1.01458052064733 -1 8.67689833962763 4517 4464 3564 4553 3837 3725 3652 4370 4488 3909 4073 4461 M12877 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS.html The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. 111/130 Gene Ontology BP GO:0090501 1.84155825392999e-07 3.76918249237052e-07 4075 3869.18181818182 4074 1.67414400734699e-08 2230 1.26722764536908 -1.45246299593328 -1 8.67223204527294 4074 4363 4068 4607 2230 3886 3350 4248 2784 4548 4403 4462 M13698 GO_AMINO_SUGAR_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_SUGAR_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. 11/17 Gene Ontology BP GO:0046348 0.000151008654682992 0.000158110546858677 4645 4070.27272727273 4077 1.37290019052875e-05 3133 1.40288392868361 -0.643856376870982 -1 5.64181433853778 4644 4303 3133 3989 4431 3976 4077 4395 4430 3341 4054 4463 M13838 GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM http://www.broadinstitute.org/gsea/msigdb/cards/GO_DEFENSE_RESPONSE_TO_GRAM_NEGATIVE_BACTERIUM.html Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. 45/140 Gene Ontology BP GO:0050829 1.32367680900739e-05 1.50221175422229e-05 3385 3699.09090909091 4078 1.20334979387058e-06 2464 1.87995877442675 -1.72055768948136 -1 9.67288403986359 3381 4445 2464 4582 4078 2753 2618 4550 4383 2871 4565 4464 M15746 GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS.html The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. 369/495 Gene Ontology BP GO:0072521 1.36609973216859e-07 3.07968122760681e-07 3800 3878.09090909091 4080 1.24190892454288e-08 2008 1.61918070650957 -1.34632928244596 -1 11.2655482944071 3797 4621 4080 4297 2008 3688 3715 4266 3441 4402 4344 4465 M14621 GO_DNA_GEOMETRIC_CHANGE http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_GEOMETRIC_CHANGE.html The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. 91/101 Gene Ontology BP GO:0032392 1.33136868113615e-05 1.50946843891971e-05 1160 3107.81818181818 4082 1.21034248928734e-06 1160 1.12556641035533 1.24691540988068 1 5.74340992398592 1160 4133 4086 4287 4082 1638 1597 2822 4115 4103 2163 4466 M10377 GO_REGULATION_OF_HISTONE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_HISTONE_METHYLATION.html Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones. 61/78 Gene Ontology BP GO:0031060 1.35895461901775e-05 1.53999411648554e-05 4220 4033.09090909091 4084 1.23542092131212e-06 3252 1.33957289706415 -1.40701081328659 -1 6.84435048004767 4216 4417 3927 3252 4084 3901 4278 4349 3548 4354 4038 4467 M11247 GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell. 3/14 Gene Ontology BP GO:0002839 3.59660776786329e-06 4.36945586001772e-06 4385 3902.45454545455 4089 3.59661358889089e-07 2588 0.994768808327765 -1.3331669426045 -1 5.64086347403774 4385 2588 4288 4117 3833 4089 3887 3669 4255 3620 4196 4468 M13866 GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_RESPONSE_TO_TUMOR_CELL.html Any process that activates or increases the frequency, rate, or extent of a response to tumor cell. 3/14 Gene Ontology BP GO:0002836 3.59660776786329e-06 4.36945586001772e-06 4390 3918 4090 3.59661358889089e-07 2589 0.994768808327765 -1.3331669426045 -1 5.64086347403774 4386 2589 4456 4118 3834 4090 3888 3662 4256 3622 4197 4469 M15293 GO_NUCLEUS_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEUS_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. 151/272 Gene Ontology BP GO:0006997 1.08604071406661e-07 2.6865217663753e-07 2915 3723.54545454545 4091 9.87309788799581e-09 1812 1.26181679781672 1.34455561458436 1 8.83498101062679 2914 4345 4133 4599 1812 3600 3515 4163 3488 4299 4091 4470 M16686 GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_HYDROGEN_ION_TRANSMEMBRANE_TRANSPORT.html The directed movement of hydrogen ion (proton) across a membrane. 85/121 Gene Ontology BP GO:1902600 0.000177162842881351 0.000184912226991236 470 3048.36363636364 4092 1.61070101054074e-05 469 1.16905614239142 -1.06407303897588 -1 4.59680530202611 469 4137 4092 4459 4445 1793 1393 1511 4299 4414 2520 4471 M10239 GO_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of mRNA metabolic process. 146/183 Gene Ontology BP GO:1903311 1.49019923165735e-05 1.68298471478195e-05 1425 3535.36363636364 4095 1.35473575074143e-06 1423 1.14752135249727 1.1625624251956 1 5.79912116498583 1423 4351 4165 4482 4095 2592 1901 3776 4324 4518 3262 4472 M13062 GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_ http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA_.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. 34/35 Gene Ontology BP GO:0000462 4.50637501496257e-05 4.8616190458198e-05 2420 3738.09090909091 4096 4.0967884764046e-06 2419 0.603208681814879 0.606034733637559 1 2.69481569363131 2419 4201 4096 4298 4295 3095 2903 2843 4610 4535 3824 4473 M13224 GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS.html Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process. 47/63 Gene Ontology BP GO:1903312 1.50362470833809e-05 1.6969114159343e-05 2810 3690.72727272727 4098 1.36694089563337e-06 1625 1.07140107535745 1.02598546137785 1 5.40279860987209 2809 4169 4031 4027 4098 2877 1625 4379 4205 4148 4230 4474 M16819 GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 50/55 Gene Ontology BP GO:0010823 2.5496053137453e-06 3.19128558546961e-06 4640 3986.81818181818 4101 2.31782569865185e-07 3004 1.51186951214756 1.82108184518501 1 8.85454614548109 4639 4164 3586 3004 3687 4479 4101 4258 3520 4365 4052 4475 M11307 GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. 22/29 Gene Ontology BP GO:0071480 4.17930361657156e-05 4.51714279393901e-05 4105 3787.90909090909 4102 3.7994391020207e-06 2384 1.57484479924632 1.40673746294138 1 7.27199172687018 4102 3995 3377 4131 4288 4158 4257 2384 3981 2582 4412 4476 M13094 GO_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. 1464/1884 Gene Ontology BP GO:0065003 8.66501117057182e-08 2.45384890956523e-07 3860 3771.27272727273 4104 8.6650115084427e-09 1688 1.81859825366678 1.90416168561496 1 12.8605718887893 3858 3850 4407 4104 1688 4287 4559 4269 1850 3961 4651 4477 M14979 GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NLS_BEARING_PROTEIN_IMPORT_INTO_NUCLEUS.html The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. 21/26 Gene Ontology BP GO:0006607 0.00137347910912793 0.00140797494927787 2590 3769.72727272727 4105 0.000124939757661442 2565 0.918848942564943 0.784828669738985 1 2.71450016628978 2588 4244 3906 3556 4531 3235 2565 4105 4276 4271 4190 4478 M16755 GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 50/72 Gene Ontology BP GO:0032784 7.35466679008814e-06 8.56602367316148e-06 3475 4121.63636363636 4105 6.68608307007052e-07 3473 0.773962542601305 -0.792817722184363 -1 4.11947447004908 3473 4438 4105 4598 3968 3675 3914 4273 4575 4501 3818 4479 M13243 GO_TOXIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TOXIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. 9/16 Gene Ontology BP GO:0009404 0.000126310353153831 0.000132758543759832 3955 4094.63636363636 4106 1.26317533165605e-05 3008 2.30720236382683 -2.51249289115639 -1 9.54049776376815 3952 3838 4416 3971 4423 4106 4589 4041 4454 3008 4243 4480 M13823 GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION.html Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. 184/225 Gene Ontology BP GO:0006352 1.50305624151198e-07 3.26708833620993e-07 3645 3873 4106 1.36641485836537e-08 2087 1.33755268896196 1.14195555098826 1 9.24939897509386 3645 4647 4106 4593 2087 3584 3954 4341 2648 4507 4491 4481 M12048 GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_DNA_DAMAGE_RECOGNITION.html The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. 26/30 Gene Ontology BP GO:0000715 6.18965156538288e-05 6.63146413394578e-05 3305 3956.54545454545 4107 5.62711428793328e-06 2413 0.534058254417569 -0.529989808756249 -1 2.29521165802022 3303 4503 4076 4305 4327 3251 2413 4107 4646 4620 3971 4482 M10303 GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_PROTEIN_COMPLEX_DISASSEMBLY.html The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. 132/145 Gene Ontology BP GO:0043624 2.51083128304295e-07 4.62205675240452e-07 3970 3989.81818181818 4108 2.28257415418262e-08 2485 1.36616160425533 -1.21517671145567 -1 9.22749839701367 3967 4352 4097 4465 2485 4108 3969 4267 3185 4549 4444 4483 M13054 GO_REGULATION_OF_CELLULAR_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_LOCALIZATION.html Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. 1317/1866 Gene Ontology BP GO:0060341 4.14109971057645e-08 1.97691467186943e-07 4110 2788.27272727273 4108 4.14109978774562e-09 334 2.03608652526985 2.16939450637996 1 14.6183566048426 4108 1154 4404 688 912 4237 4163 4455 1778 334 4438 4484 M11299 GO_PROTEIN_IMPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT.html The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event. 168/210 Gene Ontology BP GO:0017038 1.71934436180654e-06 2.24344063810596e-06 4535 4029.36363636364 4109 1.56304155046391e-07 3395 1.35340262346487 -1.51305429708845 -1 8.1381525953684 4532 4341 4109 4315 3536 4242 3849 3395 3852 4530 3622 4485 M15586 GO_PROTEIN_ACYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACYLATION.html The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. 160/188 Gene Ontology BP GO:0043543 2.64479038841261e-07 4.79961375869106e-07 3650 3757 4110 2.40435518760309e-08 2522 1.37987748440602 1.15121265764469 1 9.29689553233471 3648 4112 4110 4265 2522 3667 2758 4381 3182 4487 4195 4486 M10864 GO_MATURATION_OF_SSU_RRNA http://www.broadinstitute.org/gsea/msigdb/cards/GO_MATURATION_OF_SSU_RRNA.html Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. 43/44 Gene Ontology BP GO:0030490 0.000169518802585702 0.000177052971589511 1520 3521.72727272727 4111 1.54119878269974e-05 1517 0.654993526652425 0.663080721449323 1 2.53907925695977 1517 4185 4111 4306 4443 2585 2276 2615 4595 4566 3540 4487 M12427 GO_LEYDIG_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LEYDIG_CELL_DIFFERENTIATION.html The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. 8/13 Gene Ontology BP GO:0033327 0.00114855795160361 0.00117870316471363 2460 3482.54545454545 4111 0.000114915201720003 1268 0.798186385888831 0.644872040870653 1 2.40967615906422 2458 4311 4368 4203 4528 2642 1268 3077 4584 4111 2758 4488 M14060 GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_BY_HOST_OF_VIRAL_PROCESS.html A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. 14/15 Gene Ontology BP GO:0044794 0.000371768580146952 0.000384750712505286 3950 4003.09090909091 4111 3.38028562358466e-05 3295 1.69976037628131 -1.30242574311452 -1 6.15116836691981 3950 4292 3295 4547 4483 4014 3441 3540 4177 4184 4111 4489 M11254 GO_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_LIGASE_ACTIVITY.html Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. 137/165 Gene Ontology BP GO:0051340 4.36931406969618e-06 5.23440225702789e-06 3815 4094.81818181818 4112 3.97211158854964e-07 3482 1.33299377312962 1.3789890830871 1 7.48438681561562 3813 4349 4112 3585 3859 4331 4104 4558 3482 4353 4497 4490 M10278 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. 44/52 Gene Ontology BP GO:0042771 0.000104130406109863 0.000109918053454899 4385 3830.63636363636 4113 9.46684864883258e-06 2671 1.75964379672861 -1.37908427097621 -1 7.40516156267792 4384 4447 3299 2671 4392 4113 3374 4469 3848 4323 2817 4491 M14810 GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_SPLICING_VIA_SPLICEOSOME.html Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. 76/107 Gene Ontology BP GO:0048024 2.77264830442486e-05 3.04200249009405e-05 525 3196.54545454545 4113 2.52062113507327e-06 523 0.940827199454694 0.903267606130377 1 4.47316808557022 523 4413 4113 4312 4223 1913 1226 2716 4525 4458 2740 4492 M13443 GO_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CAPPING.html The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. 38/43 Gene Ontology BP GO:0036260 0.0154225236649717 0.0156103986541469 2990 4096 4115 0.00141197385053384 2990 0.735633469239075 0.816195593943112 1 1.32118490839356 2990 4473 4115 4611 4583 3660 3818 3697 4571 4516 4022 4493 M16451 GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. 29/48 Gene Ontology BP GO:0032786 5.48082361526022e-06 6.48912780707527e-06 3485 4054.18181818182 4115 4.98257933599371e-07 3246 0.728327732633515 -0.70942585025564 -1 3.96470137541116 3485 4199 4028 4575 3904 3525 3246 4531 4518 4470 4115 4494 M14394 GO_7_METHYLGUANOSINE_RNA_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_7_METHYLGUANOSINE_RNA_CAPPING.html The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. 38/43 Gene Ontology BP GO:0009452 0.0154225236649717 0.0156103986541469 2995 4096.27272727273 4116 0.00141197385053384 2991 0.735633469239075 0.816195593943112 1 1.32118490839356 2991 4474 4116 4612 4584 3661 3819 3690 4572 4517 4023 4495 M10435 GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATION_IN_RESPONSE_TO_STRESS.html Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 24/25 Gene Ontology BP GO:0043555 0.000450571200135917 0.000465787112693273 3990 4077 4117 4.09694096253813e-05 3108 1.09969201366719 0.913728220872019 1 3.8411715288964 3989 4505 3861 4570 4490 3578 3108 4117 4309 4227 4093 4496 M15048 GO_PROTEIN_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TRANSMEMBRANE_TRANSPORT.html The directed movement of a protein across a membrane by means of some agent such as a transporter or pore. 68/79 Gene Ontology BP GO:0071806 2.44707643202025e-05 2.69752348689653e-05 2965 3817.81818181818 4119 2.22463968314368e-06 2885 0.898143010366906 -0.74122618705111 -1 4.31568695385925 2964 4418 4119 4319 4199 3253 2885 3039 4561 4536 3703 4497 M16916 GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOBASE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. 18/21 Gene Ontology BP GO:0046112 2.89204656887354e-06 3.57130909898317e-06 3260 4046.18181818182 4119 2.62913670060766e-07 3256 0.746884287565493 0.702815871391946 1 4.27765587034483 3256 4251 3910 4219 3739 3867 4373 3978 4487 4309 4119 4498 M12893 GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_QUATERNARY_AMMONIUM_GROUP_TRANSPORT.html The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. 21/44 Gene Ontology BP GO:0015697 0.68618940391 0.68618940391 4120 4080.81818181818 4120 0.1 3276 1.20304712242318 -1.03283577447702 -1 0.0992579117533157 4120 4235 3797 4251 4635 3894 3276 4527 4476 3966 3712 4499 M15564 GO_RRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. 18/20 Gene Ontology BP GO:0016075 6.75697375903051e-06 7.90749469335235e-06 4225 3976.72727272727 4120 6.14272228378422e-07 2776 1.19654813830382 -1.13782610619339 -1 6.47533211102978 4222 4262 3826 4222 3948 3597 2776 4120 4387 3793 4591 4500 M15787 GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. 60/77 Gene Ontology BP GO:0000245 0.000121068092566969 0.000127421360487244 1595 3595.54545454545 4120 1.10067959611458e-05 1593 0.997855703176887 0.820952023715713 1 4.0812342829552 1593 4429 4120 4600 4407 2557 1704 3560 4344 4504 3733 4501 M15271 GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_METABOLIC_PROCESS.html Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. 15/17 Gene Ontology BP GO:0044252 1.6415561016492e-05 1.84274078189957e-05 2840 3671.09090909091 4122 1.49233486403887e-06 2120 1.50693466793948 1.5566896264432 1 7.58682615558338 2837 4538 3147 4532 4122 2991 2120 4289 4412 3129 4265 4502 M12744 GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_LOCALIZATION.html Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. 130/173 Gene Ontology BP GO:0071166 3.07068601795823e-05 3.3516073285385e-05 730 3288.63636363636 4125 2.79157170763507e-06 729 0.797913919612857 0.711763522310507 1 3.74025818488797 729 4125 4205 4333 4240 1934 1025 3278 4361 4625 3320 4503 M13695 GO_HISTONE_H4_K8_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K8_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. 16/16 Gene Ontology BP GO:0043982 2.08175604615062e-05 2.31344898083087e-05 4130 4057.36363636364 4126 1.89252340462307e-06 2588 0.612846508600419 -0.67338474575938 -1 2.95299584399043 4126 3529 3925 3794 4166 4084 2588 4545 4601 4633 4640 4504 M14977 GO_HISTONE_H4_K5_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K5_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. 16/16 Gene Ontology BP GO:0043981 2.08175604615062e-05 2.31344898083087e-05 4130 4058.27272727273 4127 1.89252340462307e-06 2589 0.612846508600419 -0.67338474575938 -1 2.95299584399043 4127 3530 3926 3795 4167 4085 2589 4541 4602 4638 4641 4505 M15860 GO_REGULATION_OF_MEMBRANE_PERMEABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MEMBRANE_PERMEABILITY.html Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. 93/113 Gene Ontology BP GO:0090559 5.6478865588378e-06 6.67503585427287e-06 3670 4041.27272727273 4130 5.13445550751256e-07 3667 1.35506685369021 1.53968770676344 1 7.45578080803277 3667 4130 3917 3841 3910 4246 4293 3829 4132 4352 4137 4506 M12696 GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. 15/15 Gene Ontology BP GO:0032968 8.92974733956475e-05 9.47767207367581e-05 4545 4074.63636363636 4133 8.11828165133631e-06 3342 0.811221335009407 0.793866839554674 1 3.40928230499707 4542 3795 3813 3743 4371 4110 3342 4133 4139 4215 4618 4507 M14287 GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANIC_CYCLIC_COMPOUND_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. 415/631 Gene Ontology BP GO:1901361 1.28188987933531e-07 2.9586476232873e-07 4620 3923.18181818182 4134 1.16535450366193e-08 1953 1.7067370205734 -1.62155415886414 -1 11.9129156176174 3754 4620 4134 4619 1953 3937 4372 4212 3033 4552 3969 4508 M13743 GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. 461/528 Gene Ontology BP GO:0042176 1.16907857217614e-07 2.82053557561036e-07 4265 3810.36363636364 4138 1.06279875845536e-08 1868 1.5226469271015 -1.34027104329373 -1 10.6498970874062 4261 4325 4138 4302 1868 3838 4417 4088 2202 4461 4014 4509 M12400 GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULAR_COMPLEX_DISASSEMBLY.html The disaggregation of a macromolecular complex into its constituent components. 212/249 Gene Ontology BP GO:0032984 4.20913711603456e-08 1.97691467186943e-07 3565 3713.63636363636 4139 3.82648836051421e-09 793 1.38319846858636 -1.2017859297207 -1 9.89459342397339 3564 4643 4139 4613 793 3605 3386 4306 3028 4542 4231 4510 M12694 GO_PROTEIN_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_ACETYLATION.html The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic 129/148 Gene Ontology BP GO:0006473 9.01199319934876e-07 1.29063725320313e-06 2645 3663.36363636364 4143 8.19272444635292e-08 1753 1.26895908296168 1.04335033246899 1 7.95215944146961 2644 4353 4143 4304 3217 2741 1753 4203 3934 4515 4490 4511 M12423 GO_NCRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_PROCESSING.html Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. 412/510 Gene Ontology BP GO:0034470 3.37434111785681e-06 4.12094730220151e-06 2850 3923.09090909091 4145 3.06758753945761e-07 2623 0.831349217963371 0.838704468284497 1 4.71842521530478 2849 4626 4203 4649 3783 3452 2623 3667 4534 4623 4145 4512 M16013 GO_CELLULAR_COMPONENT_DISASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_COMPONENT_DISASSEMBLY.html A cellular process that results in the breakdown of a cellular component. 552/744 Gene Ontology BP GO:0022411 4.46887205749777e-08 1.97691467186943e-07 4475 3670 4146 4.46887214736644e-09 990 1.94801695284975 -1.71132948493473 -1 13.9811573188482 4471 3588 4586 4085 990 4239 4290 3232 2205 4146 4538 4513 M14987 GO_PRE_MIRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PRE_MIRNA_PROCESSING.html Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. 11/13 Gene Ontology BP GO:0031054 0.00189624029598012 0.00193831416897968 3770 4081.72727272727 4147 0.000172534244767242 2684 0.56545436701532 -0.539844075933958 -1 1.54226841009249 3766 4588 3865 4572 4542 3542 2684 3907 4647 4639 4147 4514 M14218 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. 61/67 Gene Ontology BP GO:0000288 0.000450000811368826 0.000465300838955366 4430 3946.63636363636 4149 4.09175348656853e-05 2794 0.929162763237958 1.17953855210579 1 3.2284378616285 2794 4430 4149 4313 4489 3459 3343 3614 4429 4489 3904 4515 M16958 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_ENDONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 58/73 Gene Ontology BP GO:0090502 1.49460149560138e-07 3.25796071963426e-07 4195 3983.27272727273 4149 1.35872872467207e-08 2080 1.100227859206 0.979869754548596 1 7.58963393228818 4194 4419 3999 4579 2080 3960 3534 4086 4149 4471 4345 4516 M13856 GO_PROTEIN_FOLDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_FOLDING.html The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. 202/235 Gene Ontology BP GO:0006457 1.27790944606241e-06 1.73558454539649e-06 3635 4103.81818181818 4151 1.16173653487239e-07 3392 1.2985612775639 1.58646756384439 1 7.9600207240042 3632 4645 4151 4466 3392 4562 4305 3719 3649 4520 4101 4517 M11348 GO_RIBOSOME_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOME_ASSEMBLY.html The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. 57/75 Gene Ontology BP GO:0042255 9.07579052980381e-06 1.04761755214467e-05 3735 4081.72727272727 4153 8.25075270083382e-07 2994 0.78862891826866 0.711556993655545 1 4.12527325185679 3735 4448 4153 3846 4006 3553 2994 4453 4632 4529 4550 4518 M11985 GO_SPERM_CAPACITATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_SPERM_CAPACITATION.html A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. 13/27 Gene Ontology BP GO:0048240 7.9741214216843e-06 9.25507282990697e-06 4270 3830.72727272727 4153 7.24922756803329e-07 1806 1.40409789508889 1.25195218971974 1 7.51458176160341 4266 4282 3351 4153 3983 4267 4222 1806 3943 3232 4633 4519 M16218 GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. 760/1067 Gene Ontology BP GO:0000122 1.55623496041386e-07 3.34310307978101e-07 4410 3986.81818181818 4155 1.55623506939789e-08 2185 1.63748718390974 -1.45116408522616 -1 11.3312043406299 4408 4089 4604 4303 2185 4402 4193 4146 3389 4155 3981 4520 M10958 GO_TRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. 174/180 Gene Ontology BP GO:0006399 2.44465272527891e-06 3.07514710211483e-06 3190 4064.63636363636 4161 2.2224140379958e-07 3187 0.790083472959646 -0.827346944124656 -1 4.58700512002773 3187 4342 4190 4634 3669 3865 4161 3775 4440 4610 3838 4521 M13414 GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS.html Splicing of RNA via a series of two transesterification reactions. 291/364 Gene Ontology BP GO:0000375 2.02493418514421e-05 2.25299348720134e-05 885 3464.18181818182 4161 1.84086620307032e-06 884 0.843476685266457 0.806101148975932 1 4.11731558044307 884 4636 4207 4647 4161 2327 1609 3227 4438 4631 3339 4522 M15922 GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_IMPORT_INTO_MITOCHONDRIAL_MATRIX.html The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. 13/16 Gene Ontology BP GO:0030150 0.68618940391 0.68618940391 4650 4161.63636363636 4162 0.1 3190 0.640726425889652 0.640726425889652 1 0 3190 4589 3928 3819 4630 3780 4046 4338 4649 4647 4162 4523 M16313 GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH.html Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death. 11/18 Gene Ontology BP GO:1903209 2.03380165923884e-05 2.26231869960276e-05 3125 3605.45454545455 4162 1.84892769188128e-06 1426 0.847042705071003 -0.811889071609611 -1 4.13356091025337 3122 4581 3725 4237 4162 2631 4294 1426 4624 4651 2207 4524 M10298 GO_REGULATION_OF_RNA_STABILITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_RNA_STABILITY.html Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. 160/186 Gene Ontology BP GO:0043487 2.20789212288984e-06 2.8053855947041e-06 3520 4132.18181818182 4164 2.00717667155046e-07 3520 1.2383124193081 1.21581530030495 1 7.30674799457074 3520 4347 4164 4625 3631 3754 3981 4374 4089 4500 4469 4525 M12963 GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. 59/66 Gene Ontology BP GO:0042274 9.14759904203718e-05 9.68903672889802e-05 4170 3908.18181818182 4166 8.31634492846211e-06 2926 0.651743744935493 0.663080721449323 1 2.71008176682152 2926 4170 4162 4324 4377 3408 3150 3111 4613 4583 4166 4526 M11114 GO_MITOCHONDRIAL_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSPORT.html Transport of substances into, out of or within a mitochondrion. 214/271 Gene Ontology BP GO:0006839 1.50010560952945e-06 1.99257533575237e-06 4390 4163.18181818182 4169 1.36373330218338e-07 3471 1.33532234066989 -1.18230073979765 -1 8.1021405992707 4387 4644 4152 4330 3471 4270 3893 4091 3878 4510 4169 4527 M12031 GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that activates or increases the frequency, rate or extent of translational initiation. 21/25 Gene Ontology BP GO:0045948 4.28921713350706e-05 4.63378855867387e-05 4290 4121.09090909091 4170 3.89936432750969e-06 3625 1.22982532875969 -1.75001172176011 -1 5.63935873406981 4286 4243 3670 4230 4290 4399 4137 4170 4158 4124 3625 4528 M16236 GO_SNRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. 83/91 Gene Ontology BP GO:0016073 0.000178407366902197 0.000186169427718305 2590 3823.81818181818 4171 1.62201669416321e-05 2589 0.79312553368736 0.879958585685131 1 3.07973409861229 2589 4397 4171 4620 4446 3014 3392 3119 4503 4519 3292 4529 M10862 GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. 81/87 Gene Ontology BP GO:0006283 0.00423040068657346 0.0043072329091086 2280 3826.81818181818 4176 0.000385323393688923 2278 0.712953166905158 0.765391984732736 1 1.70724828745128 2278 4406 4176 4629 4556 3018 2851 3290 4604 4592 3695 4530 M12394 GO_PROTEIN_COMPLEX_BIOGENESIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_BIOGENESIS.html A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex. 1185/1551 Gene Ontology BP GO:0070271 5.56682836801114e-08 2.05617623085131e-07 4370 3044.54545454545 4176 5.56682850746423e-09 1164 1.93903976822201 -1.81477572482847 -1 13.8804787972598 4369 1164 4367 2057 1238 4494 4176 4544 1460 1250 4371 4531 M16814 GO_PROTEIN_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of components to form a protein complex. 1185/1551 Gene Ontology BP GO:0006461 5.56682836801114e-08 2.05617623085131e-07 4370 3071 4177 5.56682850746423e-09 1165 1.93903976822201 -1.81477572482847 -1 13.8804787972598 4370 1165 4647 2058 1239 4495 4177 4546 1461 1251 4372 4532 M14029 GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TERMINATION_OF_RNA_POLYMERASE_II_TRANSCRIPTION.html The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. 77/108 Gene Ontology BP GO:0006369 8.54320113691126e-05 9.07568833106121e-05 1390 3528.54545454545 4178 7.76684810072046e-06 1386 0.610622076309786 0.608181731874725 1 2.5506700564788 1386 4412 4178 4624 4367 2205 1568 3488 4608 4602 3376 4533 M15151 GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_ATP_SYNTHESIS_COUPLED_PROTON_TRANSPORT.html The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. 18/23 Gene Ontology BP GO:0042776 0.477392589388 0.478523851448161 4645 3964.27272727273 4178 0.0572867814827864 2388 0.57915178196564 -0.57915178196564 -1 0.0869750059226984 3054 4576 4010 3583 4643 3632 2388 4178 4653 4642 4248 4534 M12919 GO_OXIDATIVE_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_OXIDATIVE_PHOSPHORYLATION.html The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. 83/99 Gene Ontology BP GO:0006119 0.107552132830102 0.108273490709317 490 3470.54545454545 4179 0.0102909708622428 490 0.799492056138622 -0.801070432872685 -1 0.719952335248144 490 4405 4179 4331 4618 2480 1786 3363 4483 4579 3462 4535 M14886 GO_MACROMOLECULE_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. 939/1194 Gene Ontology BP GO:0009057 6.0749758599533e-08 2.10655912920796e-07 4180 3871.90909090909 4179 6.07497602602729e-09 1325 1.47516192811981 -1.27145429077386 -1 10.516048070199 4179 4599 4521 4639 1325 3770 4157 4135 2398 4604 4264 4536 M13204 GO_MRNA_3_END_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_MRNA_3_END_PROCESSING.html Any process involved in forming the mature 3' end of an mRNA molecule. 86/117 Gene Ontology BP GO:0031124 1.24862261124442e-05 1.42084641969192e-05 1980 3711.45454545455 4180 1.13511790720903e-06 1977 0.693835197771079 0.649539505948653 1 3.51671761863687 1977 4395 4180 4329 4068 2648 2167 4230 4532 4590 3710 4537 M14850 GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS.html Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). 809/1011 Gene Ontology BP GO:0080135 5.85352254574737e-08 2.0762333639785e-07 4425 3722.09090909091 4180 5.85352269993414e-09 1281 1.63147594275998 1.75722697980528 1 11.6534427949156 4425 3294 4520 4469 1281 4404 4180 4001 3017 4259 3093 4538 M13081 GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRICARBOXYLIC_ACID_METABOLIC_PROCESS.html The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-). 38/42 Gene Ontology BP GO:0072350 0.68618940391 0.68618940391 4500 4239.36363636364 4181 0.1 3917 0.941108412310559 -1.07983557592323 -1 0.0530218590285768 4498 4186 4084 4056 4650 4181 3917 4136 4310 4459 4156 4539 M14406 GO_POSTTRANSCRIPTIONAL_GENE_SILENCING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_GENE_SILENCING.html The inactivation of gene expression by a posttranscriptional mechanism. 50/58 Gene Ontology BP GO:0016441 4.1125355498629e-06 4.94972268844078e-06 4015 4061.54545454545 4181 3.73867567053359e-07 3011 1.1998817285178 1.35657936218664 1 6.75715553314798 3637 4440 4011 4292 3840 4383 4506 3011 4012 4364 4181 4540 M12918 GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_ELONGATION_FROM_RNA_POLYMERASE_II_PROMOTER.html The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. 80/90 Gene Ontology BP GO:0006368 0.00171136692158768 0.00175241863691625 2100 3763.81818181818 4182 0.00015569996685114 2099 0.751951740528771 0.818504202248845 1 2.12377285539064 2099 4411 4182 4626 4534 2847 2833 3342 4537 4578 3413 4541 M13792 GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion. 137/189 Gene Ontology BP GO:1903747 6.21005461140013e-07 9.40911237604846e-07 4185 4099.63636363636 4184 5.64550578576844e-08 3031 1.33459780695902 1.36074133762005 1 8.56704104604897 4184 3880 4025 4316 3031 4628 4620 3653 3624 4493 4642 4542 M10199 GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION.html The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. 94/104 Gene Ontology BP GO:0006354 0.000942146646148409 0.000967514532008066 1600 3523.90909090909 4187 8.56863964618643e-05 1598 0.732434041042145 0.777622796369393 1 2.26963720027831 1598 4391 4187 4633 4523 2370 2178 2580 4555 4585 3163 4543 M10551 GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DNA_TEMPLATED_TRANSCRIPTION_TERMINATION.html The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. 115/151 Gene Ontology BP GO:0006353 3.69915419956645e-05 4.01122453753966e-05 1165 3421.63636363636 4189 3.36292399986998e-06 1162 0.674166866299304 0.679373019102658 1 3.08587931300977 1162 4376 4189 4636 4270 2139 1575 2922 4565 4609 3195 4544 M10980 GO_CELLULAR_RESPONSE_TO_CADMIUM_ION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_RESPONSE_TO_CADMIUM_ION.html Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. 14/24 Gene Ontology BP GO:0071276 5.71443863415326e-07 8.81315312055523e-07 4375 3919.18181818182 4189 5.19494556223936e-08 2285 2.64541728766288 1.04111899383486 1 17.1736590671066 4371 4553 2285 4517 2979 4627 4511 4093 4189 3356 3630 4545 M16240 GO_PEPTIDYL_LYSINE_DIMETHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_LYSINE_DIMETHYLATION.html The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. 15/15 Gene Ontology BP GO:0018027 0.000207271051846677 0.000215853223868082 4255 4174.81818181818 4189 1.88445983892174e-05 3843 0.882398131324416 1.12690358297252 1 3.37792654959711 4254 4281 3843 4022 4457 4481 3931 4189 4451 4041 3973 4546 M10405 GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTAGLANDIN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. 19/30 Gene Ontology BP GO:0001516 7.2072235630802e-07 1.06902171625796e-06 4510 3944.18181818182 4190 6.55202356743223e-08 2197 2.44485845525934 1.15071716305026 1 15.6418286433604 4510 4523 2197 4545 3102 4190 3774 4557 4504 3605 3879 4547 M10586 GO_TELOMERE_CAPPING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_CAPPING.html A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. 16/30 Gene Ontology BP GO:0016233 5.77545300442207e-05 6.19340466226685e-05 2910 3510.90909090909 4190 5.25054966138941e-06 557 1.01611341955517 0.650932247408929 1 4.50156332720818 2910 4286 3757 4254 4323 2017 557 4206 4190 4247 3873 4548 M11141 GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION.html Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. 30/52 Gene Ontology BP GO:0050869 3.04422650697221e-05 3.32350678952175e-05 3405 3888.45454545455 4191 2.76751693813408e-06 2661 1.99608459062754 -2.13998882760608 -1 9.53444615231119 3401 4191 2661 4523 4239 4019 4343 4503 4289 2966 3638 4549 M13860 GO_REGULATION_OF_MRNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_POLYADENYLATION.html Any process that modulates the frequency, rate or extent of mRNA polyadenylation. 13/13 Gene Ontology BP GO:1900363 0.00993750904926754 0.0100717119595386 3275 3983.63636363636 4191 0.000907516655011704 2852 0.653593940795987 -0.697801116194301 -1 1.29547162970036 3273 4298 3892 4245 4576 4006 4191 3807 4362 4318 2852 4550 M16690 GO_PROSTANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROSTANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure. 19/30 Gene Ontology BP GO:0046457 7.2072235630802e-07 1.06902171625796e-06 4515 3946.18181818182 4191 6.55202356743223e-08 2198 2.44485845525934 1.15071716305026 1 15.6418286433604 4511 4524 2198 4546 3103 4191 3775 4556 4505 3619 3880 4551 M11131 GO_MITOCHONDRIAL_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. 110/119 Gene Ontology BP GO:0032543 0.0234847181659865 0.0237449790583083 2195 3983.45454545455 4194 0.00215811148411853 2194 0.701951192806805 -0.757632384753703 -1 1.11751686331058 2194 4380 4194 4484 4589 3701 3393 3658 4580 4601 4044 4552 M12598 GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY.html Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. 32/35 Gene Ontology BP GO:0033146 0.000472372886429292 0.000487891462942397 4340 3574.81818181818 4195 4.29522129498454e-05 423 1.67866197696891 1.58082717442249 1 5.88655073698841 4340 4195 3661 2998 4492 4607 4414 2110 423 4321 3762 4553 M14399 GO_GDP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GDP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. 15/17 Gene Ontology BP GO:0046710 0.000245303358935978 0.000254832893308575 4295 3687.45454545455 4195 2.23027922641315e-05 977 1.87987790877675 -1.24907474445202 -1 7.17797534789173 4295 4033 3135 3980 4578 4195 4469 977 4314 2196 4390 4554 M16222 GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_PHOSPHODIESTER_BOND_HYDROLYSIS_EXONUCLEOLYTIC.html The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. 35/35 Gene Ontology BP GO:0090503 7.2267650070157e-07 1.07123725956177e-06 4195 4094.90909090909 4195 6.56978852811991e-08 3105 1.08006623793094 -1.01396185759353 -1 6.84591524907437 4195 4468 4039 4585 3105 3802 3334 4358 4162 4382 4614 4555 M16373 GO_TRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_PROCESSING.html The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. 112/118 Gene Ontology BP GO:0008033 2.37041997385651e-06 2.99228544176732e-06 3935 4255.90909090909 4196 2.15492957081969e-07 3656 0.80782761158991 -0.823551105068672 -1 4.70290511647563 3934 4366 4186 4621 3656 4149 4525 4196 4459 4588 4135 4556 M11662 GO_TRANSLATIONAL_TERMINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_TERMINATION.html The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). 92/100 Gene Ontology BP GO:0006415 0.0631211890703996 0.0636271431422377 4600 3948.36363636364 4198 0.00590986241950522 2051 0.699856700001812 -0.760132094438432 -1 0.790520027469163 2051 4398 4198 4483 4599 3657 3217 3654 4590 4596 3989 4557 M15788 GO_SNRNA_PROCESSING http://www.broadinstitute.org/gsea/msigdb/cards/GO_SNRNA_PROCESSING.html Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. 23/23 Gene Ontology BP GO:0016180 4.68437293239874e-06 5.58023227200494e-06 4150 4163.81818181818 4198 4.25852991516215e-07 3378 0.784379169808671 -0.629221416061981 -1 4.33400139073001 4147 4506 3959 4571 3880 4045 3378 4288 4461 4198 4369 4558 M10506 GO_ICOSANOID_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ICOSANOID_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids. 37/58 Gene Ontology BP GO:0046456 1.79601032057092e-05 2.00740716349183e-05 4200 4021.81818181818 4200 1.63274998436174e-06 2155 2.14444905054775 1.20087069929198 1 10.7582804379455 4200 4181 2155 4550 4141 4453 3948 4249 4397 3599 4367 4559 M12055 GO_NUCLEAR_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSPORT.html The directed movement of substances into, out of, or within the nucleus. 384/481 Gene Ontology BP GO:0051169 6.05733353095365e-07 9.22276600769874e-07 4330 3729.27272727273 4200 5.50666836249107e-08 1946 1.25561008630867 1.03298280267742 1 8.06508229729387 2807 4326 4200 4327 3015 2869 1946 4571 3734 4589 4638 4560 M12155 GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION.html Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. 478/568 Gene Ontology BP GO:0010608 4.05852325522645e-07 6.71800380881133e-07 4615 4116.09090909091 4201 3.68956727630566e-08 2773 1.42736979426474 1.45254340880072 1 9.39580672076345 3886 4615 4201 4643 2773 4073 4033 4614 3306 4597 4536 4561 M15813 GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of fatty acid derivative. 37/58 Gene Ontology BP GO:1901570 1.79601032057092e-05 2.00740716349183e-05 4205 4023.81818181818 4201 1.63274998436174e-06 2156 2.14444905054775 1.20087069929198 1 10.7582804379455 4201 4182 2156 4551 4142 4454 3949 4261 4398 3600 4368 4562 M13729 GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CIRCADIAN_RHYTHM.html Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. 11/24 Gene Ontology BP GO:0042753 0.323564459705481 0.324750955782917 4300 3691.45454545455 4203 0.0349139502678115 2405 1.59236246797982 1.70002445175815 1 0.726316422480127 4298 2549 3201 2886 4619 4203 4479 4433 2405 2901 4632 4563 M10069 GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION.html Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion. 100/140 Gene Ontology BP GO:1903214 4.15908527679031e-07 6.82858990575346e-07 4265 4022 4204 3.7809873300571e-08 2797 1.25895293254917 1.14995982289887 1 8.26420683709606 4263 4367 4026 4310 2797 3889 4204 4398 3587 4484 3917 4564 M14685 GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_AMIDE_METABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. 381/456 Gene Ontology BP GO:0034248 2.00618489428284e-07 3.98071569854928e-07 4010 4030.36363636364 4208 1.82380461566119e-08 2304 1.4924600604229 1.57261418789157 1 10.1955081075727 4008 4622 4174 4341 2304 4208 4070 4420 3206 4582 4399 4565 M15478 GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY.html The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. 139/229 Gene Ontology BP GO:0000184 0.0268549695693201 0.0271289998710479 3655 4209.36363636364 4213 0.0024716815334522 3652 0.804560909288275 -0.657952639462847 -1 1.24716345231797 3652 4386 4213 3849 4592 3958 4028 4057 4586 4645 4337 4566 M10904 GO_NEGATIVE_REGULATION_OF_DNA_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_DNA_REPAIR.html Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. 15/17 Gene Ontology BP GO:0045738 0.0176928658562891 0.017900609878085 4590 4200.90909090909 4214 0.00162152532619504 3628 1.02357763548989 -0.70124386706183 -1 1.81691940592241 4450 4568 3793 4042 4586 4548 3940 3628 4588 4214 3853 4567 M10990 GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CHROMOSOME_LOCALIZATION_TO_NUCLEAR_ENVELOPE_INVOLVED_IN_HOMOLOGOUS_CHROMOSOME_SEGREGATION.html The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. 6/12 Gene Ontology BP GO:0090220 0.00158190229882181 0.00162020501792161 2610 3430.45454545455 4217 0.000158302951500878 1524 0.666215116240765 0.666215116240765 1 1.89322241748684 2606 4597 4273 4217 4565 2333 1524 1598 4636 4611 2775 4568 M14270 GO_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_ELONGATION.html The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. 109/123 Gene Ontology BP GO:0006414 0.0100282324614001 0.0101614472218847 2515 4028.36363636364 4219 0.000915839807754868 2514 0.798172558183574 -0.713142493017071 -1 1.60373660664989 2514 4381 4209 4631 4577 3674 3262 3828 4418 4599 4219 4569 M13899 GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER.html Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. 145/173 Gene Ontology BP GO:0006367 2.90292856808906e-07 5.17125827998407e-07 4440 3892.63636363636 4221 2.63902631921302e-08 2571 1.37671325175059 1.14509033880321 1 9.22719251185305 4438 4346 4049 4573 2571 4221 4552 3689 2596 4441 3343 4570 M15049 GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR.html A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. 65/76 Gene Ontology BP GO:0072332 4.51239438590774e-06 5.39331391667833e-06 4420 4137 4222 4.10218512841265e-07 3476 1.6061323789613 -1.33300970942868 -1 9.01864372203914 4418 4409 3476 4233 3867 4210 4030 4601 3735 4306 4222 4571 M10085 GO_CYTOPLASMIC_TRANSLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATION.html The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. 53/70 Gene Ontology BP GO:0002181 2.25322469848713e-05 2.49150535220072e-05 3655 4208.81818181818 4223 2.04840706926243e-06 3653 0.816280512353796 0.784337962708825 1 3.94241517138514 3653 4457 4146 4326 4185 4297 3790 4078 4629 4513 4223 4572 M15553 GO_GMP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GMP_METABOLIC_PROCESS.html The chemical reactions and pathways involving GMP, guanosine monophosphate. 21/27 Gene Ontology BP GO:0046037 8.60265620439895e-05 9.13676314062276e-05 4630 3875.45454545455 4223 7.82090237484782e-06 1349 1.67361854141029 1.87675741678663 1 7.18260726340589 4626 4223 3437 4406 4368 4421 4154 1349 4200 2844 4602 4573 M16197 GO_HISTONE_H3_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H3_ACETYLATION.html The modification of histone H3 by the addition of an acetyl group. 46/51 Gene Ontology BP GO:0043966 2.7877549488873e-05 3.05713499344158e-05 2670 3790.63636363636 4225 2.53435479533361e-06 1679 1.14437011097542 0.744428515838384 1 5.4627204772074 2666 4451 4063 4299 4225 2788 1679 4495 4384 4482 4165 4574 M16124 GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM http://www.broadinstitute.org/gsea/msigdb/cards/GO_SYMBIOSIS_ENCOMPASSING_MUTUALISM_THROUGH_PARASITISM.html An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. 775/1069 Gene Ontology BP GO:0044403 1.25867522062398e-07 2.92538251826343e-07 3920 3989.45454545455 4226 1.25867529191583e-08 2019 1.43032953039773 -1.3376322982477 -1 9.97287294209363 3916 4603 4595 4344 2019 3882 4440 4226 3691 4581 3587 4575 M11920 GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT.html The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. 69/99 Gene Ontology BP GO:1990542 0.68618940391 0.68618940391 4015 4266.63636363636 4228 0.1 3838 0.93829210848139 -0.911014689878506 -1 0.0525247397892006 4011 4424 4160 4073 4647 4177 3838 4228 4564 4505 4306 4576 M12317 GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION.html A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. 118/140 Gene Ontology BP GO:0007006 1.00354817925677e-05 1.15125978256454e-05 4035 4195.09090909091 4230 9.12320688230864e-07 3501 1.24264031682067 1.39320684837993 1 6.51034571351827 3501 4355 4075 4618 4031 4230 4411 4034 4147 4447 4297 4577 M13161 GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 20/21 Gene Ontology BP GO:0002183 0.68618940391 0.68618940391 3805 4219.27272727273 4232 0.1 3802 1.07735612816521 1.00231536527991 1 0.0770715940645786 3802 4565 4006 4296 4634 4458 3807 4160 4594 4232 3858 4578 M10348 GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_G_PROTEIN_COUPLED_PURINERGIC_NUCLEOTIDE_RECEPTOR_SIGNALING_PATHWAY.html The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. 6/15 Gene Ontology BP GO:0035589 2.63164519263304e-07 4.78135301886823e-07 4410 3500 4235 2.63164550428313e-08 906 3.77082590258205 -3.32855567639654 -1 25.6085645454121 4407 2960 4235 2511 2568 4603 4470 4291 3120 906 4429 4579 M16937 GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal. 220/261 Gene Ontology BP GO:1903322 1.37928675905199e-06 1.85208511294157e-06 4575 3989.18181818182 4235 1.25389783981323e-07 2556 1.48044317559107 1.49399415249654 1 9.04569476853841 4573 4332 4045 3255 3433 4478 4235 4490 2556 4344 4140 4580 M11866 GO_AMINO_ACID_BETAINE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_AMINO_ACID_BETAINE_TRANSPORT.html The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 20/40 Gene Ontology BP GO:0015838 0.68618940391 0.68618940391 4240 4176.27272727273 4236 0.1 3754 1.20304712242318 -1.03283577447702 -1 0.0992579117533157 4327 4236 3754 4236 4644 4186 4097 4260 4470 3914 3815 4581 M14122 GO_PROTEIN_K48_LINKED_DEUBIQUITINATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_K48_LINKED_DEUBIQUITINATION.html A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. 20/28 Gene Ontology BP GO:0071108 3.41508386174174e-05 3.71357448204822e-05 4580 3705.54545454545 4236 3.10466988691914e-06 605 1.60722498125088 -1.15844521183577 -1 7.57139820089547 4578 4522 3544 3234 4258 4614 3795 3080 605 4236 4295 4582 M15131 GO_HISTONE_H4_K16_ACETYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_H4_K16_ACETYLATION.html The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. 21/21 Gene Ontology BP GO:0043984 4.5413081509236e-06 5.42508519287485e-06 4645 4068.09090909091 4238 4.12847047750878e-07 2905 0.612846508600419 -0.67338474575938 -1 3.36958290237836 3770 4238 3991 4267 3869 3664 2905 4397 4644 4641 4363 4583 M13309 GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION.html Any process that modulates the frequency, rate, or extent of interleukin-1 production. 54/103 Gene Ontology BP GO:0032652 9.73499366790984e-05 0.000102924166182196 4630 3891.09090909091 4243 8.85038587980703e-06 2184 1.84914885447052 -2.03744489583672 -1 7.84456055365381 4628 3915 2498 4243 4386 4629 3864 3816 4349 2184 4290 4584 M10437 GO_MULTI_ORGANISM_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_TRANSPORT.html The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. 76/115 Gene Ontology BP GO:0044766 2.71467446223396e-06 3.37737440448519e-06 3025 3942.72727272727 4244 2.46788891999375e-07 2673 0.867693168487356 0.673046032664321 1 5.01056935777454 3024 4393 4130 4602 3709 3096 2673 4244 4419 4497 4583 4585 M14352 GO_CYCLOOXYGENASE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYCLOOXYGENASE_PATHWAY.html The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. 12/22 Gene Ontology BP GO:0019371 3.12727849765948e-05 3.41017737276999e-05 4295 3948 4246 2.84302086591124e-06 2032 2.60072294887442 -4.26574309022848 -1 12.4254238588753 4291 4299 2032 4172 4246 4447 4315 3984 4540 3499 3603 4586 M10121 GO_HEMOGLOBIN_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HEMOGLOBIN_METABOLIC_PROCESS.html The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. 11/15 Gene Ontology BP GO:0020027 0.0694864656621601 0.0700131062637572 4525 4124.81818181818 4253 0.00652576481323166 3092 1.0584678058342 1.10672841693632 1 1.20609064749782 4525 4304 3390 4211 4601 4013 4380 3092 4554 4253 4050 4587 M14361 GO_GRANULOCYTE_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_GRANULOCYTE_DIFFERENTIATION.html The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. 11/18 Gene Ontology BP GO:0030851 0.02032309629034 0.0205527857072272 4595 4074.36363636364 4255 0.00186484553527106 2478 2.27888546982158 -3.92696841149941 -1 4.03630395040756 4255 4592 3560 4559 4594 4086 3806 2478 4444 4256 4188 4588 M15918 GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_LYMPHOID_PROGENITOR_CELL_DIFFERENTIATION.html The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. 9/13 Gene Ontology BP GO:0002320 2.97545132163443e-05 3.24994718299648e-05 3520 3765.18181818182 4262 2.97549116228276e-06 470 2.30692481489501 -2.30692481489501 -1 11.0610102875422 3518 4307 4581 4410 4570 4378 4262 470 3977 3902 3042 4589 M11322 GO_REGULATION_OF_TRANSLATIONAL_ELONGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_ELONGATION.html Any process that modulates the frequency, rate, extent or accuracy of translational elongation. 25/25 Gene Ontology BP GO:0006448 0.00077148257379261 0.000793305727261219 4180 4293.36363636364 4264 7.01593859533807e-05 3955 0.938279578956092 1.13144805702608 1 3.02659345102389 4177 4514 3983 4264 4517 4173 4476 4609 4127 4432 3955 4590 M10379 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 21/25 Gene Ontology BP GO:1900153 7.49942695655803e-05 7.9960663677508e-05 4170 4173.63636363636 4267 6.81789328318857e-06 3439 0.94952822818661 1.11514649193062 1 4.08547380251442 4170 4517 3845 4450 4350 3554 3439 4561 4551 4267 4206 4591 M13106 GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SPLICING_VIA_ENDONUCLEOLYTIC_CLEAVAGE_AND_LIGATION.html Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. 18/20 Gene Ontology BP GO:0000394 0.000213127234013936 0.000221902219706164 4275 4247.54545454545 4271 1.93770803392596e-05 3895 0.858323298248626 -0.962798789729327 -1 3.27156065952483 4271 4250 3895 4020 4458 4426 4255 4313 4381 4308 4146 4592 M16889 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_DEADENYLATION_DEPENDENT_DECAY.html Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. 21/25 Gene Ontology BP GO:1900151 7.49942695655803e-05 7.9960663677508e-05 4175 4175.45454545455 4272 6.81789328318857e-06 3440 0.94952822818661 1.11514649193062 1 4.08547380251442 4171 4518 3846 4451 4351 3555 3440 4567 4552 4272 4207 4593 M14187 GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE http://www.broadinstitute.org/gsea/msigdb/cards/GO_RETROGRADE_TRANSPORT_ENDOSOME_TO_PLASMA_MEMBRANE.html The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. 14/15 Gene Ontology BP GO:1990126 7.57018239484665e-07 1.1087207643444e-06 4440 3870 4279 6.88198636340145e-08 1798 0.651434468729414 -0.681316233447826 -1 4.07368166248339 4437 4279 3847 4017 3144 3494 1798 4475 4455 4343 4281 4594 M12577 GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY.html The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. 27/40 Gene Ontology BP GO:0000027 0.175357814438461 0.176190868188762 3410 3985.27272727273 4280 0.017375072861575 2151 0.986469827711157 0.703013432256482 1 0.689650482364813 3407 4532 4042 4059 4610 3239 2151 4280 4641 4455 4422 4595 M10037 GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_VIRAL_TRANSCRIPTION.html Any process that activates or increases the frequency, rate or extent of viral transcription. 47/51 Gene Ontology BP GO:0050434 6.33438711368807e-05 6.78340695972166e-05 3690 4140.09090909091 4281 5.75869954995439e-06 3523 0.968109355514198 0.974398419414017 1 4.24226432690378 3687 4441 4052 4281 4334 3523 3703 4584 4072 4370 4494 4596 M11174 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. 820/988 Gene Ontology BP GO:0070647 1.23686564346557e-07 2.89711184326466e-07 4605 4063.63636363636 4281 1.23686571230822e-08 2005 1.33969270234223 1.39290977814015 1 9.33984490596259 3900 4601 4281 4640 2005 4262 4254 4295 3231 4603 4628 4597 M14409 GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS http://www.broadinstitute.org/gsea/msigdb/cards/GO_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS.html Any process in which an organism has an effect on an organism of a different species. 775/1069 Gene Ontology BP GO:0044419 1.25867522062398e-07 2.92538251826343e-07 3915 3984.54545454545 4284 1.25867529191583e-08 2018 1.43032953039773 -1.3376322982477 -1 9.97287294209363 3915 4602 4492 4343 2018 3881 4439 4284 3690 4580 3586 4598 M12436 GO_GLYCOGEN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLYCOGEN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. 26/33 Gene Ontology BP GO:0005978 0.000483612686057561 0.000499278861376932 4485 4180.27272727273 4288 4.39744571305723e-05 3170 0.957124023979562 -0.837144649793167 -1 3.29737638955108 4482 4224 3920 3820 4493 4363 3170 4185 4596 4288 4442 4599 M11256 GO_SULFATE_TRANSPORT http://www.broadinstitute.org/gsea/msigdb/cards/GO_SULFATE_TRANSPORT.html The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. 7/14 Gene Ontology BP GO:0008272 2.20095676354301e-05 2.43718510727407e-05 4290 3865.27272727273 4289 2.20097856279492e-06 1838 1.48652471805135 -1.50753396222864 -1 7.28773677819462 4475 2959 4289 3883 4197 4290 4492 3214 4442 1838 4439 4600 M15244 GO_GLUCAN_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLUCAN_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. 26/33 Gene Ontology BP GO:0009250 0.000483612686057561 0.000499278861376932 4485 4179.54545454545 4290 4.39744571305723e-05 3171 0.957124023979562 -0.837144649793167 -1 3.29737638955108 4483 4225 3921 3821 4494 4364 3171 4166 4597 4290 4443 4601 M13663 GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_LIGASE_ACTIVITY.html Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. 115/139 Gene Ontology BP GO:0051351 4.45987706797457e-05 4.81257142794195e-05 4360 4118.90909090909 4294 4.05451589265454e-06 3425 1.3553912597117 1.44614751783555 1 6.20263856672126 3593 4357 4101 4057 4294 4358 4121 4301 3425 4403 4298 4602 M16293 GO_UTP_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_UTP_METABOLIC_PROCESS.html The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate. 9/13 Gene Ontology BP GO:0046051 0.00404078733835063 0.00411507627168866 4300 4306.09090909091 4296 0.00040481537803324 3839 0.706844756184535 -0.609941618682267 -1 1.70677202825193 4296 3839 4613 4201 4557 4251 3968 4486 4535 4173 4448 4603 M12250 GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION.html Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. 232/301 Gene Ontology BP GO:0010821 3.19653250025844e-07 5.57267355702604e-07 4645 4106 4299 2.90593905882264e-08 2628 1.41768512791774 1.51938327080402 1 9.45549016449242 4645 4638 4081 4317 2628 4215 4306 4276 3214 4547 4299 4604 M10378 GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_FISSION.html Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. 16/17 Gene Ontology BP GO:0090141 0.000102050283841499 0.000107820156837987 4305 4266.90909090909 4301 9.27772890033441e-06 3695 1.04679645393324 0.967475918805526 1 4.36890275278413 4349 4264 3695 4221 4389 4301 4081 4487 4599 4246 4304 4605 M11453 GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS.html Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. 9/15 Gene Ontology BP GO:0060456 0.000314115970508391 0.000325519289705021 4140 4224.45454545455 4302 3.14160380322857e-05 3531 2.57737338937296 -1.45704855668846 -1 9.58745785049018 4140 4306 4302 4174 4478 4372 4335 4119 4557 3531 4155 4606 M14908 GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that modulates the frequency, rate or extent of cellular protein catabolic process. 315/354 Gene Ontology BP GO:1903362 2.00311208775003e-07 3.97760141854629e-07 4275 3959.09090909091 4304 1.82101115466774e-08 1844 1.47844819516301 1.63579802329761 1 10.0992687651075 4273 4627 4142 4307 2301 4304 4108 4514 1844 4495 4635 4607 M11491 GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_ACUTE_INFLAMMATORY_RESPONSE.html Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response. 7/21 Gene Ontology BP GO:0002674 0.204684938742251 0.205612914500797 4400 3992.18181818182 4307 0.0226414406767482 1912 1.12240980049055 1.24790760552088 1 0.719031853416475 4396 4082 4307 3227 4648 4411 1912 4586 4399 3677 4269 4608 M13896 GO_MULTI_ORGANISM_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_LOCALIZATION.html A localization which involves another organism. 76/115 Gene Ontology BP GO:1902579 2.71467446223396e-06 3.37737440448519e-06 3025 3949.36363636364 4307 2.46788891999375e-07 2674 0.867693168487356 0.673046032664321 1 5.01056935777454 3025 4394 4131 4603 3710 3097 2674 4307 4420 4498 4584 4609 M15703 GO_ZINC_ION_HOMEOSTASIS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ZINC_ION_HOMEOSTASIS.html Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. 19/27 Gene Ontology BP GO:0055069 6.67436843829909e-06 7.81278901720897e-06 4490 3970.72727272727 4313 6.0676260791906e-07 2787 2.2238271067266 -2.5439413150794 -1 12.1442913821368 4489 3758 2787 4508 3947 4639 4457 3257 4313 2918 4605 4610 M10661 GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_DISRUPTION_OF_CELLS_OF_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. 5/23 Gene Ontology BP GO:0051818 0.6513215599 0.652443319314252 4645 4352.63636363636 4314 0.1 3876 1.28220730084723 -1.92865388149996 -1 0.143537726390326 4642 4314 4254 4196 4632 4568 4281 3876 4619 3903 4594 4611 M11656 GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL.html A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. 109/138 Gene Ontology BP GO:0070646 1.42565099209162e-06 1.90619369718457e-06 4315 4195 4314 1.29604719631577e-07 3451 1.03545893226409 0.895692996733458 1 6.27881495408809 4583 4373 4154 4314 3451 4484 3980 4074 3867 4551 4314 4612 M10606 GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_MRNA_CATABOLIC_PROCESS.html Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 35/39 Gene Ontology BP GO:0061013 5.26993135789379e-05 5.65912545771516e-05 4465 4095.36363636364 4317 4.79096145390311e-06 3152 1.02869652703851 -1.01640518587352 -1 4.60220713710408 3866 4465 3981 4464 4317 4414 4122 3152 4506 4379 3383 4613 M13239 GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION_OR_REMOVAL.html Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal. 322/377 Gene Ontology BP GO:1903320 3.20757092810793e-07 5.58409786295704e-07 4495 4003.81818181818 4318 2.91597399615239e-08 2631 1.41031047483861 1.34911270819082 1 9.4043616094446 4493 4625 4144 4318 2631 4482 4424 3861 2998 4454 3612 4614 M15162 GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_ORGANONITROGEN_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of organonitrogen compound. 969/1252 Gene Ontology BP GO:1901566 7.58003598855698e-08 2.29469567498056e-07 4495 3925.63636363636 4319 7.58003624711323e-09 1542 1.73740881050131 -1.51998605946984 -1 12.3359828259648 4492 4319 4538 4130 1542 4055 4092 4425 2471 4491 4627 4615 M15067 GO_REGULATION_OF_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_INITIATION.html Any process that modulates the frequency, rate or extent of translational initiation. 89/99 Gene Ontology BP GO:0006446 1.9653690241195e-05 2.18986160661591e-05 4360 4291.45454545455 4323 1.78671507450414e-06 3937 1.04672358409856 -1.21718114457464 -1 5.15063344469304 4358 4390 4158 4323 4155 4330 3937 4501 4214 4546 4294 4616 M13371 GO_NCRNA_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_NCRNA_METABOLIC_PROCESS.html The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). 550/678 Gene Ontology BP GO:0034660 1.92227637366e-06 2.47628791988925e-06 3610 4101 4328 1.92227803647793e-07 3098 0.906559175454391 0.86344157800779 1 5.37193552853641 3610 4613 4424 4650 3610 3784 3098 3976 4328 4630 4388 4617 M15215 GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_THREONYLCARBAMOYLADENOSINE_METABOLIC_PROCESS.html The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. 11/11 Gene Ontology BP GO:0070525 8.40993839296424e-05 8.93615970369094e-05 4520 4254.72727272727 4334 7.6456908152946e-06 3725 0.687329071740414 -0.698017910412988 -1 2.89028662360539 4334 4060 3762 4200 4365 4205 3725 4520 4517 4643 4471 4618 M10650 GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION.html Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. 27/55 Gene Ontology BP GO:0032731 0.000499160815435099 0.000514916761073903 4365 4076.90909090909 4338 4.53885551508774e-05 2621 1.74555830288544 -1.82127083936171 -1 6.08153423561917 4364 3982 2621 4218 4497 4115 4650 4519 4338 2933 4609 4619 M15034 GO_RNA_POLYADENYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_POLYADENYLATION.html The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. 32/35 Gene Ontology BP GO:0043631 1.40772296137107e-06 1.88493091777255e-06 4455 4217.18181818182 4340 1.27974896557937e-07 3443 0.906873139100749 -1.01404482834296 -1 5.48981974533384 4341 4466 4020 4453 3443 4309 4591 3747 4340 4453 4226 4620 M15831 GO_PEPTIDYL_ASPARAGINE_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PEPTIDYL_ASPARAGINE_MODIFICATION.html The modification of peptidyl-asparagine. 35/40 Gene Ontology BP GO:0018196 0.0884468383617668 0.0890786014929222 3030 4092.27272727273 4342 0.0083833316306141 2984 1.08682705402785 1.37281528329624 1 1.11875298640915 3028 4472 3871 4462 4628 4612 4342 2984 4302 4381 3933 4621 M14922 GO_MULTI_ORGANISM_METABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_MULTI_ORGANISM_METABOLIC_PROCESS.html A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism. 160/247 Gene Ontology BP GO:0044033 0.000132404995529344 0.00013897596304941 3780 4245.27272727273 4345 1.20375422613499e-05 3778 0.881532045939818 0.958489521984701 1 3.5564213023047 3778 4374 4211 4347 4420 4345 4024 3879 4585 4637 4098 4622 M12160 GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER.html The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). 663/904 Gene Ontology BP GO:0006366 3.72488644722505e-07 6.28878687915028e-07 3705 3955.63636363636 4347 3.72488707159026e-08 2781 1.54354019225132 1.58361859635771 1 10.217480098249 3702 4607 4347 4479 2781 3472 2914 4634 3493 4567 4516 4623 M15932 GO_RNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. 250/362 Gene Ontology BP GO:0006401 1.66685979263513e-06 2.18414492118593e-06 4220 4328.63636363636 4348 1.51532823232305e-07 3521 1.02293785914894 -1.00704258834236 -1 6.13626053387864 4220 4651 4216 4348 3521 4510 4326 4474 4401 4648 4300 4624 M13783 GO_VIRAL_LIFE_CYCLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_VIRAL_LIFE_CYCLE.html A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. 322/480 Gene Ontology BP GO:0019058 6.08205981782618e-08 2.10720955564745e-07 4635 4121.36363636364 4353 5.52914544179014e-09 1231 1.29008870436163 1.33882357767442 1 9.18233303732062 4618 4632 4184 4635 1231 4630 4349 4028 4125 4550 4353 4625 M10353 GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CYTOPLASMIC_MRNA_PROCESSING_BODY_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. 19/23 Gene Ontology BP GO:0033962 0.000220463530742685 0.000229386585095195 4280 4311.45454545455 4354 2.00441478769549e-05 3643 1.25082953957347 -1.47288257977106 -1 4.79989753361184 4434 4528 3643 4445 4461 4354 4532 4277 4146 4329 4277 4626 M16046 GO_PHOSPHORYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PHOSPHORYLATION.html The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. 1131/1444 Gene Ontology BP GO:0016310 7.12810404697611e-08 2.23814099129341e-07 4320 3968 4361 7.12810427562052e-09 1475 1.75915239792001 -1.5578781576368 -1 12.5123581109541 4514 4317 4590 4436 1475 4403 4361 4320 2541 4143 4548 4627 M13539 GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_RIBONUCLEOPROTEIN_COMPLEX_SUBUNIT_ORGANIZATION.html Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. 223/271 Gene Ontology BP GO:0071826 2.55127689199889e-06 3.19201166401474e-06 3035 4075.63636363636 4370 2.31934531876938e-07 3032 0.954497071866589 0.79717627107065 1 5.54839349533042 3032 4650 4208 4641 3689 3519 3113 4515 4370 4632 4463 4628 M12863 GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_GUANOSINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS.html The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines). 13/17 Gene Ontology BP GO:1901070 9.0743481933307e-05 9.6179822650496e-05 3975 4299 4376 8.24974773174882e-06 3844 0.797552705850908 0.772321279247731 1 3.34443863656897 3971 4569 3844 4033 4376 4341 4535 4643 4463 4131 4383 4629 M10644 GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_CELLULAR_PROTEIN_CATABOLIC_PROCESS.html Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process. 220/244 Gene Ontology BP GO:1903364 4.03024806340072e-07 6.69262820806694e-07 4320 3974.72727272727 4379 3.6638625470132e-08 1701 1.5196769454828 1.7675050945576 1 10.0134374358811 4317 4639 4062 3836 2765 4526 4379 4394 1701 4457 4646 4630 M12629 GO_TELOMERE_LOCALIZATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TELOMERE_LOCALIZATION.html Any process in which a telomere is transported to, and/or maintained in, a specific location. 7/12 Gene Ontology BP GO:0034397 0.00379591271432266 0.00386739256836947 4595 3467.18181818182 4379 0.000380241237446158 1219 0.666215116240765 0.666215116240765 1 1.62154937708743 2326 4595 4379 4555 4593 2303 1219 1926 4637 4624 2982 4631 M12109 GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 19/21 Gene Ontology BP GO:0060213 9.30039553932561e-05 9.84411748054642e-05 4100 4278.72727272727 4380 8.45526248400189e-06 3514 0.65741230749892 -0.742505398506601 -1 2.7297436183332 4096 4536 3955 4460 4380 4518 4149 4373 4650 4435 3514 4632 M13248 GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_ARREST.html Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases. 35/47 Gene Ontology BP GO:0071157 0.0028733391348603 0.00292872880492989 3010 4132.09090909091 4380 0.000261554433976763 3008 0.914143455778467 -0.912639864783411 -1 2.38620672764548 3008 4469 3969 4463 4554 3591 4452 3935 4549 4380 4083 4633 M12888 GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. 19/21 Gene Ontology BP GO:0060211 9.30039553932561e-05 9.84411748054642e-05 4100 4277.27272727273 4381 8.45526248400189e-06 3515 0.65741230749892 -0.742505398506601 -1 2.7297436183332 4097 4537 3956 4461 4381 4519 4150 4347 4651 4436 3515 4634 M15006 GO_REGULATION_OF_TRANSLATIONAL_FIDELITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_REGULATION_OF_TRANSLATIONAL_FIDELITY.html Any process that modulates the ability of the translational apparatus to interpret the genetic code. 16/16 Gene Ontology BP GO:0006450 8.99901703543003e-05 9.54248547535459e-05 4175 4357.27272727273 4390 8.18125923446316e-06 3961 0.689866169997825 -0.878576021578862 -1 2.88014599115633 4172 4567 3961 4584 4374 4597 4009 4187 4605 4390 4484 4635 M11783 GO_AEROBIC_RESPIRATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_AEROBIC_RESPIRATION.html The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. 59/63 Gene Ontology BP GO:0009060 0.114882881031318 0.115603383529135 4180 4334.72727272727 4397 0.0110328058409044 3775 1.08951611572197 1.20351659502653 1 0.988699116847048 4176 4426 4137 4308 4605 4600 4547 4233 3775 4478 4397 4636 M14426 GO_GROOMING_BEHAVIOR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GROOMING_BEHAVIOR.html The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. 9/18 Gene Ontology BP GO:0007625 0.0325363177608166 0.0328611865728412 4305 4108.09090909091 4402 0.00330227470927863 2434 1.86567393539075 -1.74763312779526 -1 2.87355177567828 4304 4590 4493 4402 4596 4220 4224 2658 4625 2434 4643 4637 M13163 GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY http://www.broadinstitute.org/gsea/msigdb/cards/GO_COMPLEMENT_ACTIVATION_ALTERNATIVE_PATHWAY.html Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. 9/17 Gene Ontology BP GO:0006957 0.00728226122403844 0.00739348930295676 2765 3809.81818181818 4413 0.000730623596987214 2429 1.84821281125355 -2.26343624189506 -1 4.13780058837144 2762 4591 4413 4528 4569 3829 4627 2833 4490 2429 2837 4638 M14880 GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NEGATIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY.html Any process that stops or reduces the activity of a monooxygenase. 13/24 Gene Ontology BP GO:0032769 0.000195720038600283 0.000203915212630344 4445 4054 4429 1.7794313885365e-05 2254 1.11802813402462 -0.841195167562111 -1 4.33996157762674 4441 4559 3528 4429 4454 4362 2254 3989 4458 3639 4481 4639 M16875 GO_TRNA_MODIFICATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRNA_MODIFICATION.html The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. 58/58 Gene Ontology BP GO:0006400 2.11928210029151e-05 2.3501000030163e-05 4565 4299.45454545455 4431 1.92663865074928e-06 3194 0.814341295532774 -0.853035740660865 -1 3.95508215846183 4561 4431 4141 4475 4175 4312 3194 4506 4519 4553 4427 4640 M11077 GO_TRANSLATIONAL_INITIATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_TRANSLATIONAL_INITIATION.html The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. 172/281 Gene Ontology BP GO:0006413 0.00260555936661016 0.00265695107009359 4365 4397.36363636364 4436 0.000237150034056055 3850 0.706640898298081 -0.623096894791666 -1 1.85114237520456 4362 4365 4192 3850 4552 4350 4436 4472 4645 4613 4534 4641 M16593 GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_CELLULAR_MACROMOLECULAR_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. 734/956 Gene Ontology BP GO:0034622 3.94652873768104e-07 6.58179147542289e-07 4545 4117 4446 3.94652943856022e-08 2633 1.5274455715676 1.44499485350976 1 10.0771601760117 4545 4604 4638 4627 2831 4446 4322 4100 2633 4577 3964 4642 M15974 GO_MACROMOLECULE_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_MACROMOLECULE_METHYLATION.html The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. 188/226 Gene Ontology BP GO:0043414 3.30210787820397e-06 4.03909252294508e-06 4590 4297.54545454545 4449 3.00192075867276e-07 3775 1.18297380024641 0.999313909197497 1 6.77307362550097 4587 4652 4169 4480 3775 4502 4449 4082 3988 4560 4029 4643 M15269 GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_MITOCHONDRION.html A process in which a protein is transported to, or maintained in, a location within the mitochondrion. 80/92 Gene Ontology BP GO:0070585 0.000109718993797576 0.000115659827399212 4035 4417 4452 9.97495146499423e-06 4033 1.03561893270025 1.04794715334828 1 4.28697514186381 4033 4410 4148 4623 4398 4652 4460 4560 4327 4524 4452 4644 M12715 GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX http://www.broadinstitute.org/gsea/msigdb/cards/GO_FORMATION_OF_TRANSLATION_PREINITIATION_COMPLEX.html The joining of the small ribosomal subunit, ternary complex, and mRNA. 22/23 Gene Ontology BP GO:0001731 0.0569135921795638 0.0573946563527331 4470 4258.63636363636 4466 0.00531287013300262 3584 1.29859818342761 -0.456185078883427 -1 1.62632912290176 4494 4543 4054 3840 4598 3716 3584 4462 4466 4467 4621 4645 M13046 GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEOTIDE_EXCISION_REPAIR_PREINCISION_COMPLEX_ASSEMBLY.html The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. 32/36 Gene Ontology BP GO:0006294 0.00182626819091698 0.00186884228993549 4290 4377.90909090909 4470 0.000166162361851828 4083 0.699392946274919 0.805269907224087 1 1.94633806386893 4288 4481 4083 4470 4537 4471 4219 4204 4623 4521 4260 4646 M14123 GO_RNA_SECONDARY_STRUCTURE_UNWINDING http://www.broadinstitute.org/gsea/msigdb/cards/GO_RNA_SECONDARY_STRUCTURE_UNWINDING.html The process in which a secondary structure of RNA are broken or 'melted'. 40/45 Gene Ontology BP GO:0010501 0.000408245712332112 0.000422219893194336 3995 4216.63636363636 4471 3.71201353307184e-05 3190 0.659562815182081 -0.710902351033252 -1 2.28891458366974 3991 4471 4132 4309 4486 3747 3190 4478 4529 4557 4493 4647 M15919 GO_METHYLATION http://www.broadinstitute.org/gsea/msigdb/cards/GO_METHYLATION.html The process in which a methyl group is covalently attached to a molecule. 249/308 Gene Ontology BP GO:0032259 2.84865148264104e-06 3.52426890420866e-06 4650 4311.63636363636 4481 2.58968651927284e-07 3734 1.22214236846185 1.08467208572336 1 7.07917930117914 4648 4637 4181 4481 3734 4488 4500 4292 3856 4568 4043 4648 M16950 GO_PROTEIN_TARGETING_TO_MITOCHONDRION http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_TARGETING_TO_MITOCHONDRION.html The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. 60/69 Gene Ontology BP GO:0006626 0.000383785224584258 0.000397010371274022 3985 4413.81818181818 4484 3.48956537672098e-05 3985 0.920216050526175 0.888513781223742 1 3.26472107301394 3985 4437 4150 4617 4484 4609 4396 4333 4531 4486 4524 4649 M14619 GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING http://www.broadinstitute.org/gsea/msigdb/cards/GO_NUCLEAR_TRANSCRIBED_MRNA_POLY_A_TAIL_SHORTENING.html Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. 30/32 Gene Ontology BP GO:0000289 0.000464229370768242 0.000479586869934421 4650 4427.81818181818 4488 4.22115780283339e-05 3937 0.855236380691808 -0.676686171332519 -1 2.95045525934969 4647 4488 4065 4293 4491 4610 4645 3937 4475 4430 4625 4650 M14653 GO_PROTEIN_LOCALIZATION_TO_ORGANELLE http://www.broadinstitute.org/gsea/msigdb/cards/GO_PROTEIN_LOCALIZATION_TO_ORGANELLE.html A process in which a protein is transported to, or maintained in, a location within an organelle. 637/807 Gene Ontology BP GO:0033365 1.04941751211837e-07 2.64657043934525e-07 4640 4198 4508 1.04941756167584e-08 1856 1.36703157744071 -1.15898199076753 -1 9.59070360997891 4637 4610 4508 4345 1856 4104 4503 4574 3830 4600 4611 4651 M13221 GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR http://www.broadinstitute.org/gsea/msigdb/cards/GO_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR.html The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. 37/44 Gene Ontology BP GO:0070911 0.00140203194956506 0.00143692833949917 4530 4453.36363636364 4528 0.0001275387495131 4108 0.64053897995116 0.698892864440616 1 1.85193852184899 4528 4476 4108 4614 4532 4587 4208 4238 4640 4628 4428 4652 M14800 GO_HISTONE_MRNA_CATABOLIC_PROCESS http://www.broadinstitute.org/gsea/msigdb/cards/GO_HISTONE_MRNA_CATABOLIC_PROCESS.html The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). 14/14 Gene Ontology BP GO:0071044 0.00187102784383221 0.00191380359581255 4570 4341.54545454545 4539 0.000170238271714048 3575 0.589802895794797 -0.558190999246838 -1 1.61706665855511 4376 4573 3948 3575 4539 4570 4066 4283 4622 4636 4569 4653 M15234 GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION http://www.broadinstitute.org/gsea/msigdb/cards/GO_KILLING_OF_CELLS_IN_OTHER_ORGANISM_INVOLVED_IN_SYMBIOTIC_INTERACTION.html Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. 5/23 Gene Ontology BP GO:0051883 0.6513215599 0.652443319314252 4645 4379.63636363636 4544 0.1 3873 1.28220730084723 -1.92865388149996 -1 0.143537726390326 4643 4315 4544 4197 4633 4569 4282 3873 4620 3905 4595